BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= TM0252b.3
(889 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
ANC2_HUMAN (Q9UJX6) Anaphase promoting complex subunit 2 (APC2) ... 304 8e-82
ANC2_MOUSE (Q8BZQ7) Anaphase promoting complex subunit 2 (APC2) ... 301 4e-81
ANC2_CAEEL (P34514) Anaphase-promoting complex subunit 2 (APC2) ... 165 6e-40
APC2_YEAST (Q12440) Anaphase promoting complex subunit 2 81 1e-14
CUL3_SCHPO (Q09760) Cullin 3 homolog (Cul-3) 70 2e-11
CU4A_HUMAN (Q13619) Cullin homolog 4A (CUL-4A) 62 9e-09
CU4B_HUMAN (Q13620) Cullin homolog 4B (CUL-4B) 61 1e-08
CUL1_CAEEL (Q17389) Cullin 1 (Abnormal cell lineage 19 protein) 57 2e-07
CUL4_CAEEL (Q17392) Cullin 4 55 6e-07
CUL1_DROME (Q24311) Cullin homolog 1 (Lin-19 homolog protein) 54 2e-06
CUL1_SCHPO (O13790) Cullin 1 homolog (Cul-1) (Cell division cont... 52 9e-06
CUL1_MOUSE (Q9WTX6) Cullin homolog 1 (CUL-1) 50 2e-05
CUL1_HUMAN (Q13616) Cullin homolog 1 (CUL-1) 50 2e-05
CUL3_CAEEL (Q17391) Cullin 3 49 8e-05
CUL3_YEAST (P53202) Cullin B (Cullin 3) 48 1e-04
CUL2_CAEEL (Q17390) Cullin 2 46 4e-04
CUL4_SCHPO (O14122) Cullin 4 homolog (Cul-4) 45 7e-04
CUL2_HUMAN (Q13617) Cullin homolog 2 (CUL-2) 44 0.001
CUL2_MOUSE (Q9D4H8) Cullin homolog 2 (CUL-2) 44 0.002
CUL6_CAEEL (Q21346) Cullin 6 42 0.007
>ANC2_HUMAN (Q9UJX6) Anaphase promoting complex subunit 2 (APC2)
(Cyclosome subunit 2)
Length = 822
Score = 304 bits (778), Expect = 8e-82
Identities = 231/829 (27%), Positives = 388/829 (45%), Gaps = 147/829 (17%)
Query: 60 VNCLCKHGLHSLVRDHFLRVLEETFERNAASVWRHFEPYAAGFSKNDDLDDSVLYHVLEE 119
V L HGLHS++ + F+ VL+ + N + + ++ + +
Sbjct: 59 VEVLRGHGLHSVLEEWFVEVLQNDLQANISPEF---------------------WNAISQ 97
Query: 120 ICVEKHYQEKCLLILVNALQSYKDQMSEETHNFEAERNY-------------LTSKYHWI 166
C + +CLL+L++A + ++ + E + L + H +
Sbjct: 98 -CENSADEPQCLLLLLDAFGLLESRLDPYLRSLELLEKWTRLGLLMGTGAQGLREEVHTM 156
Query: 167 VSSVLMATLPPVFPVILHLYF---------KRRLEELSIIMDVEFHDDTSQNKDSMDLDE 217
+ VL + P F ++ + +R E ++E D+ +
Sbjct: 157 LRGVLFFSTPRTFQEMIQRLYGCFLRVYMQSKRKGEGGTDPELEGELDSRYARRRYYRLL 216
Query: 218 KGKICNNVGDMDVDDECYNNHRLSGSSRRLVKNIGKVVLGLRSLGFTS-MAEDAYASAIF 276
+ +C G +C+ R+ ++ ++ L L ++ +A + +
Sbjct: 217 QSPLC--AGCSSDKQQCW--------CRQALEQFHQLSQVLHRLSLLERVSAEAVTTTLH 266
Query: 277 LLLKAKVYNVAGDDFRGSILQSIQRWIQAVPLQFLHALLVYIGDSVSYESTSSGLKSPLA 336
+ + ++ + ++ S L+ +WI+ V + ++G + G P +
Sbjct: 267 QVTRERMEDRCRGEYERSFLREFHKWIERV--------VGWLGKVFLQD----GPARPAS 314
Query: 337 PQPSSFCSGIDTPSEGLVRWKLRLEYFAYETLQDLRIAKLFEIIVDYPESSPAIEDLKLC 396
P+ + L RW+ ++ F Y LRI +LF I+ D+P+S PAIEDLK C
Sbjct: 315 PEAGNT----------LRRWRCHVQRFFYRIYASLRIEELFSIVRDFPDSRPAIEDLKYC 364
Query: 397 LEYTGQHSKLVESF------------ISDCVI----------------------AVGEPI 422
LE T Q +L+ S ++ C I EPI
Sbjct: 365 LERTDQRQQLLVSLKAALETRLLHPGVNTCDIITLYISAIKALRVLDPSMVILEVACEPI 424
Query: 423 RDYLRGRRDTIKCIVTMLTDGSGGNSSASGNTGDSLLEELNRDEEIQENVGVDDDFNTDD 482
R YLR R DT++ IV LT S G TGD L EL++ + G D + ++ +
Sbjct: 425 RRYLRTREDTVRQIVAGLTGDSDG-------TGD-LAVELSKTDPASLETGQDSEDDSGE 476
Query: 483 REAWINASRWQPDPVEADPLKGSRNQRKVDILGMIVGIIGSKDQLVHEYRTMLAEKLLNK 542
E W+ PDPV+ADP K S +R DI+ ++V I GSKD ++EYR++LA++LL++
Sbjct: 477 PEDWV------PDPVDADPGKSSSKRRSSDIISLLVSIYGSKDLFINEYRSLLADRLLHQ 530
Query: 543 SDYDIDSEIRTLELLKIHFGESSLQKCEIMLNDLIGSKRINSNIKATISQ-PSQTNVEVE 601
+ + EIR +ELLK+ FGE+ + CE+ML D+ S+RIN+NI+ + P++
Sbjct: 531 FSFSPEREIRNVELLKLRFGEAPMHFCEVMLKDMADSRRINANIREEDEKRPAEEQPPF- 589
Query: 602 DNAISMDNIAATIISSNFWPPIQVEPLNLPEPVDKLLSDYAKRFNEIKTPRKLQWKKSLG 661
+ A I+SS FWPP + E L +PE + L Y K++ ++K R L WK +LG
Sbjct: 590 -------GVYAVILSSEFWPPFKDEKLEVPEDIRAALEAYCKKYEQLKAMRTLSWKHTLG 642
Query: 662 TVKLELQLKDRVLQFTVAPVHASIIMNFQDQTSWTSKNLAAAVGIPVDALNRRMSFWISK 721
V ++++L DR L V PV A I++ FQDQ SWT + L+ AV +PV L RRMS W+ +
Sbjct: 643 LVTMDVELADRTLSVAVTPVQAVILLYFQDQASWTLEELSKAVKMPVALLRRRMSVWLQQ 702
Query: 722 GVVAESSGGDSSDHVYTIMESMVETKKRDSSGITQELLGGGDEEEDRAVASIENQLRKEM 781
GV+ E G ++++E E + +D + +L D+E D +AS +Q +E+
Sbjct: 703 GVLREEPPG-----TFSVIE---EERPQDRDNM---VLIDSDDESDSGMASQADQKEEEL 751
Query: 782 SIYEKFIMGMLTNFGSMALDRIHNRLKVRMVLHQCPKTKGIVLQLVNGW 830
++ +I MLTN S++LDRI+N L RM + P I LQ + G+
Sbjct: 752 LLFWTYIQAMLTNLESLSLDRIYNML--RMFVVTGPALAEIDLQELQGY 798
>ANC2_MOUSE (Q8BZQ7) Anaphase promoting complex subunit 2 (APC2)
(Cyclosome subunit 2)
Length = 837
Score = 301 bits (772), Expect = 4e-81
Identities = 232/828 (28%), Positives = 389/828 (46%), Gaps = 145/828 (17%)
Query: 60 VNCLCKHGLHSLVRDHFLRVLEETFERNAASVWRHFEPYAAGFSKNDDLDDSVLYHVLEE 119
V L HGLHS++ + F+ VL+ + N A+ E + A + + +D+
Sbjct: 74 VEVLRGHGLHSVLEEWFVEVLQNDLQGNIAT-----EFWNAIALRENSVDEP-------- 120
Query: 120 ICVEKHYQEKCLLILVNALQSYKDQMSEETHNFEAERNY-------------LTSKYHWI 166
+CL +L++A + ++ H+ E + L K H +
Sbjct: 121 ---------QCLGLLLDAFGLLESRLDPYLHSLELLEKWTRLGLLMGAGAQGLREKVHTM 171
Query: 167 VSSVLMATLPPVFPVILHLYFKRRLE---------ELSIIMDVEFHDDTSQNKDSMDLDE 217
+ VL + P F ++ + R L E ++E D+ +
Sbjct: 172 LRGVLFFSTPRTFQEMVQRLYGRFLRVYMQSKRKGEGGTDPELEGELDSRYARRRYYRLL 231
Query: 218 KGKICNNVGDMDVDDECYNNHRLSGSSRRLVKNIGKVVLGLRSLGFTS-MAEDAYASAIF 276
+ +C G C R+ ++ ++ L L + +A + +
Sbjct: 232 QSPLCAGCGSDKQQCWC----------RQALEQFNQLSQVLHRLSLLERVCAEAVTTTLH 281
Query: 277 LLLKAKVYNVAGDDFRGSILQSIQRWIQAVPLQFLHALLVYIGDSVSYESTSSGLKSPLA 336
+ + ++ + ++ S L+ +WI+ V + ++G ++ + P +
Sbjct: 282 QVTRERMEDRCRGEYERSFLREFHKWIERV--------VGWLGKVFLQDNPTR----PTS 329
Query: 337 PQPSSFCSGIDTPSEGLVRWKLRLEYFAYETLQDLRIAKLFEIIVDYPESSPAIEDLKLC 396
P+ + L RW+ ++ F Y LRI +LF II D+P+S PAIEDLK C
Sbjct: 330 PEAGNT----------LRRWRCHVQRFFYRIYATLRIEELFSIIRDFPDSRPAIEDLKYC 379
Query: 397 LEYTGQHSKLVESF------------ISDCVI----------------------AVGEPI 422
LE T Q +L+ S ++ C I EPI
Sbjct: 380 LERTDQRQQLLVSLKVALETRLLHPGVNTCDIITLYISAIKALRVLDPSMVILEVACEPI 439
Query: 423 RDYLRGRRDTIKCIVTMLTDGSGGNSSASGNTGDSLLEELNRDEEIQENVGVDDDFNTDD 482
R YLR R DT++ IV LT S G TGD L EL++ + G D + ++ +
Sbjct: 440 RRYLRTREDTVRQIVAGLTGDSDG-------TGD-LAVELSKTDPACLETGQDSEDDSGE 491
Query: 483 REAWINASRWQPDPVEADPLKGSRNQRKVDILGMIVGIIGSKDQLVHEYRTMLAEKLLNK 542
E W+ PDPV+ADP+K S +R DI+ ++V I GSKD ++EYR++LA++LL++
Sbjct: 492 PEDWV------PDPVDADPVKSSSKRRSSDIISLLVSIYGSKDLFINEYRSLLADRLLHQ 545
Query: 543 SDYDIDSEIRTLELLKIHFGESSLQKCEIMLNDLIGSKRINSNIKATISQPSQTNVEVED 602
+ + EIR +ELLK+ FGE+ + CE+ML D+ S+RIN+NI+ + + VE +
Sbjct: 546 FSFSPEREIRNVELLKLRFGEAPMHFCEVMLKDMADSRRINANIR---EEDEKRPVEEQP 602
Query: 603 NAISMDNIAATIISSNFWPPIQVEPLNLPEPVDKLLSDYAKRFNEIKTPRKLQWKKSLGT 662
+ A I+SS FWPP + E L +PE + L Y K++ ++K R L WK +LG
Sbjct: 603 PF----GVYAVILSSEFWPPFKDEKLEVPEDIRAALDVYCKKYEKLKAMRTLSWKHTLGL 658
Query: 663 VKLELQLKDRVLQFTVAPVHASIIMNFQDQTSWTSKNLAAAVGIPVDALNRRMSFWISKG 722
V ++++L DR L V PV A +++ FQ+Q SWT + L+ V +PV L RRMS W+ +G
Sbjct: 659 VTMDVELADRTLSVAVTPVQALVLLYFQNQASWTLEELSKVVKMPVALLRRRMSVWLQQG 718
Query: 723 VVAESSGGDSSDHVYTIMESMVETKKRDSSGITQELLGGGDEEEDRAVASIENQLRKEMS 782
V+ E G ++++E E + +D + +L D+E D +AS +Q +E+
Sbjct: 719 VLREEPPG-----TFSVIE---EERPQDRDNM---VLIDSDDESDSGMASQADQKEEELL 767
Query: 783 IYEKFIMGMLTNFGSMALDRIHNRLKVRMVLHQCPKTKGIVLQLVNGW 830
++ +I MLTN S++L+RI++ L RM + P I LQ + G+
Sbjct: 768 LFWAYIQAMLTNLESLSLERIYSML--RMFVMTGPALAEIDLQELQGY 813
>ANC2_CAEEL (P34514) Anaphase-promoting complex subunit 2 (APC2)
(Cyclosome subunit 2)
Length = 728
Score = 165 bits (417), Expect = 6e-40
Identities = 111/390 (28%), Positives = 201/390 (51%), Gaps = 30/390 (7%)
Query: 422 IRDYLRGRRDTIKCIVTMLTDGSGGNSSASGNTGDSLLEELNRDEEIQENVGVDDDFNTD 481
IR+YL+ R DT++ I++ +T S + + ++ + +EE++ GV+DDF +
Sbjct: 313 IREYLKRRPDTVQQIISYIT--SNKKNELEKDMSKTVRSAMMDEEELK---GVNDDFLPE 367
Query: 482 DREAWINASRWQPDPVEADPLKGSRNQRKVDILGMIVGIIGSKDQLVHEYRTMLAEKLLN 541
+ E + W P+P +A G+ + VD+ M+V + GSK+ V EYR +LAE+L +
Sbjct: 368 NMET-LGWENWMPNPTDATVGDGAPGHQGVDVFNMLVSVYGSKELFVKEYRNLLAERLSS 426
Query: 542 KSDYDIDSEIRTLELLKIHFGESSLQKCEIMLNDLIGSKRINSNIKATISQPSQTNVEVE 601
+ D + E R L+LLK+ F S LQ CE+ML D+I S I+ + +S+ S N +V
Sbjct: 427 SDNKDPEFEKRYLDLLKLRFQYSELQHCEVMLRDVIHSLDIDKKFE-DMSERSAGNYDV- 484
Query: 602 DNAISMDNIAATIISSNFWPPIQVEPLN--LPEPVDKLLSDYAKRFNEIKTPRKLQWKKS 659
+ I+A IISS++WP ++ E +P+P+ + Y + + ++K RKL+W +S
Sbjct: 485 ----PIIPISACIISSHYWPKLETEKTEALMPQPLQAAMDVYQETYLDVKRDRKLEWLRS 540
Query: 660 LGTVKLELQLKDRVLQFTVAPVHASIIMNFQDQTSWTSKNLAAAVGIPVDALNRRMSFWI 719
+G V++ + + + T+ ++A ++ F ++ +WT+ + +G+ V +R+ + +
Sbjct: 541 VGCVEVSINIDGVEVDRTIPNMYALLLFLFLEKETWTTAEVVEKMGMSVVVTRKRLEWLV 600
Query: 720 SKGVVAESSGGDSSDHVYTIMESMVETKKRDSSGITQELLGGGDEEEDRAVASIENQ--- 776
+G + + I+ S T R+ SGI+ G D E+D V EN
Sbjct: 601 KQGFIC----------MNPIISSDTWTLTRNPSGISIVRPGTPDLEDDEDVEPEENSDMV 650
Query: 777 --LRKEMSIYEKFIMGMLTNFGSMALDRIH 804
L + FI N G + +R+H
Sbjct: 651 DALEQYWGYTRNFIANHAPN-GEVKAERMH 679
>APC2_YEAST (Q12440) Anaphase promoting complex subunit 2
Length = 853
Score = 80.9 bits (198), Expect = 1e-14
Identities = 90/386 (23%), Positives = 170/386 (43%), Gaps = 50/386 (12%)
Query: 492 WQPDPVEADPLKGSRNQRKVDILGMIVGIIGSKDQLVHEYRTMLAEKLLNKSDYDIDSE- 550
W P+P + P + K ++ +++ + S++ + E+R +L ++L Y +D +
Sbjct: 470 WVPEPNDMIPGNIKSSYIKTNLFEVLLDLFESREFFISEFRNLLTDRLFTLKFYTLDEKW 529
Query: 551 IRTLELLK---IHFGESSLQKCEIMLNDLIGSKRINSNIKATISQPSQTNVEV------- 600
R L+L++ + F E+S + N ++G + A Q + +++V
Sbjct: 530 TRCLKLIREKIVKFTETS--HSNYITNGILGLLETTAPA-ADADQSNLNSIDVMLWDIKC 586
Query: 601 -EDNAISMDNIAAT-------IISSNFWP------PIQVEPLNLPEPVDKLLSDYAKRFN 646
E+ M +A IS +W +LP +++ L Y+ ++
Sbjct: 587 SEELCRKMHEVAGLDPIIFPKFISLLYWKYNCDTQGSNDLAFHLPIDLERELQKYSDIYS 646
Query: 647 EIKTPRKLQWKKSLGTVKLELQLKD-RVLQFTVAPVHASIIMNF----QDQTSWTSKNLA 701
++K RKLQ K G V+++L KD R L V+ S+I F + + + L+
Sbjct: 647 QLKPGRKLQLCKDKGKVEIQLAFKDGRKLVLDVSLEQCSVINQFDSPNDEPICLSLEQLS 706
Query: 702 AAVGIPVDALNRRMSFWISKGVVAESSGGDSSDHVYTIMESMVETKKRDSSGITQELLGG 761
++ I L + FWI KGV+ + +G Y+++E + E+
Sbjct: 707 ESLNIAPPRLTHLLDFWIQKGVLLKENG------TYSVIEHSEMDFDQAQKTAPMEIENS 760
Query: 762 GDEEEDRAVASIENQLRKEMSIYEKFIMGMLTNFGSMALDRIHNRLKVRMVLHQCPKTKG 821
E + + + +L + S+ FI GMLTN G+M L +IH+ LK+ + PK G
Sbjct: 761 NYELHNDSEIERKYELTLQRSL--PFIEGMLTNLGAMKLHKIHSFLKITV-----PKDWG 813
Query: 822 ---IVLQLVNGWTVDTLIMISYIHYV 844
I LQ + G+ ++TL + Y+
Sbjct: 814 YNRITLQQLEGY-LNTLADEGRLKYI 838
>CUL3_SCHPO (Q09760) Cullin 3 homolog (Cul-3)
Length = 785
Score = 70.1 bits (170), Expect = 2e-11
Identities = 49/175 (28%), Positives = 82/175 (46%), Gaps = 14/175 (8%)
Query: 521 IGSKDQLVHEYRTMLAEKLLNKSDYDIDSEIRTLELLKIHFGESSLQKCEIMLNDLIGSK 580
I KD Y+T LA++LLN D+E+ + LK G QK E M ND+
Sbjct: 459 ISEKDVFEKYYKTHLAKRLLNNRSISSDAELGMISRLKQEAGNVFTQKLEGMFNDM---- 514
Query: 581 RINSNIKATISQPSQTNVEVEDNAISMDNIAATIISSNFWPPIQVEP----LNLPEPVDK 636
N+ + Q + N ++ ++D + +I++S FW PI + P N P+ +
Sbjct: 515 ----NLSQELLQEYKHNSALQSAKPALD-LNVSILASTFW-PIDLSPHKIKCNFPKVLLA 568
Query: 637 LLSDYAKRFNEIKTPRKLQWKKSLGTVKLELQLKDRVLQFTVAPVHASIIMNFQD 691
+ + + T RKL W S+G+ + + KDR V+ + + I++ FQD
Sbjct: 569 QIDQFTDFYLSKHTGRKLLWYPSMGSADVRVNFKDRKYDLNVSTIASVILLLFQD 623
>CU4A_HUMAN (Q13619) Cullin homolog 4A (CUL-4A)
Length = 659
Score = 61.6 bits (148), Expect = 9e-09
Identities = 48/208 (23%), Positives = 90/208 (43%), Gaps = 9/208 (4%)
Query: 508 QRKVDILGMIVGIIGSKDQLVHEYRTMLAEKLLNKSDYDIDSEIRTLELLKIHFGESSLQ 567
+R +D + ++ I KD Y+ LA++LL +D+E L LK G +
Sbjct: 330 ERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTS 389
Query: 568 KCEIMLNDLIGSKRINSNIKATISQPSQTNVEVEDNAISMDNIAATIISSNFWPPIQVEP 627
K E M D+ SK I + K + S + ++ I++ +WP
Sbjct: 390 KLEGMFKDMELSKDIMVHFKQHMQNQSDSGPI---------DLTVNILTMGYWPTYTPME 440
Query: 628 LNLPEPVDKLLSDYAKRFNEIKTPRKLQWKKSLGTVKLELQLKDRVLQFTVAPVHASIIM 687
++L + KL + + + RKLQW+ +LG L+ + K+ +F V+ +++
Sbjct: 441 VHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLL 500
Query: 688 NFQDQTSWTSKNLAAAVGIPVDALNRRM 715
F + ++ + + A GI L R +
Sbjct: 501 MFNEGDGFSFEEIKMATGIEDSELRRTL 528
>CU4B_HUMAN (Q13620) Cullin homolog 4B (CUL-4B)
Length = 895
Score = 61.2 bits (147), Expect = 1e-08
Identities = 51/209 (24%), Positives = 92/209 (43%), Gaps = 11/209 (5%)
Query: 508 QRKVDILGMIVGIIGSKDQLVHEYRTMLAEKLLNKSDYDIDSEIRTLELLKIHFGESSLQ 567
++ +D + +I I KD Y+ LA++LL +D+E L LK G +
Sbjct: 566 EKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTS 625
Query: 568 KCEIMLNDLIGSKRINSNIKATI-SQPSQTNVEVEDNAISMDNIAATIISSNFWPPIQVE 626
K E M D+ SK I K + +Q N+E+ N ++M +WP
Sbjct: 626 KLEGMFKDMELSKDIMIQFKQYMQNQNVPGNIELTVNILTM----------GYWPTYVPM 675
Query: 627 PLNLPEPVDKLLSDYAKRFNEIKTPRKLQWKKSLGTVKLELQLKDRVLQFTVAPVHASII 686
++LP + KL + + + RKLQW+ +LG L+ + K+ + V+ ++
Sbjct: 676 EVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVL 735
Query: 687 MNFQDQTSWTSKNLAAAVGIPVDALNRRM 715
+ F + ++ + + A GI L R +
Sbjct: 736 LMFNEGEEFSLEEIKQATGIEDGELRRTL 764
>CUL1_CAEEL (Q17389) Cullin 1 (Abnormal cell lineage 19 protein)
Length = 780
Score = 57.0 bits (136), Expect = 2e-07
Identities = 49/218 (22%), Positives = 89/218 (40%), Gaps = 19/218 (8%)
Query: 487 INASRWQPDPVEADPLKGSRNQRKVDILGMIVGIIGSKDQLVHEYRTMLAEKLLNKSDYD 546
+ S PD E + L Q K+ + + I KD Y M +++L+++
Sbjct: 434 LRKSSKMPDEAELEEL-----QTKIMV---VFKYIDDKDVFSKFYTKMFSKRLISELSAS 485
Query: 547 IDSEIRTLELLKIHFGESSLQKCEIMLNDLIGSKRINSNIKATISQP-SQTNVEVEDNAI 605
++E + LK G + M+ND SK + ++ K + Q +VE
Sbjct: 486 DEAEANFITKLKSMCGYEYTARLSKMVNDTQVSKDLTADFKEKKADMLGQKSVEFN---- 541
Query: 606 SMDNIAATIISSNFWPPIQVEPLNLPEPVDKLLSDYAKRFNEIKTPRKLQWKKSLGTVKL 665
++SS WP P+ LP+ + K + + + +NE R+L W S ++
Sbjct: 542 ------VLVLSSGSWPTFPTTPITLPQQLSKTIEIFGQFYNEKFNGRRLTWVYSQSRGEI 595
Query: 666 ELQLKDRVLQFTVAPVHASIIMNFQDQTSWTSKNLAAA 703
+ FT ++ F +Q S+T + +AAA
Sbjct: 596 TSTAFPKKYVFTATTAQMCTMLLFNEQDSYTVEQIAAA 633
>CUL4_CAEEL (Q17392) Cullin 4
Length = 840
Score = 55.5 bits (132), Expect = 6e-07
Identities = 51/267 (19%), Positives = 101/267 (37%), Gaps = 38/267 (14%)
Query: 511 VDILGMIVGIIGSKDQLVHEYRTMLAEKLLNKSDYDIDSEIRTLELLKIHFGESSLQKCE 570
VD ++ + KD Y+ LA++L + +D+E L LK G + K E
Sbjct: 504 VDEAIVLFRYLRGKDVFEAYYKRGLAKRLFLERSASVDAEKMVLCKLKTECGSAFTYKLE 563
Query: 571 IMLNDLIGSKRINSNIKATISQPSQTNVEVEDNAISMDNIAATIISSNFWPPIQVEPLNL 630
M D+ S+ + ++ N A +I+ +WP +N+
Sbjct: 564 GMFKDMDASENYGRLFNQYLEHMNKEKA----------NFTARVITPEYWPTYDTYEINI 613
Query: 631 PEPVDKLLSDYAKRFNEIKTPRKLQWKKSLGTVKLELQLKDRVLQFTVAPVHASII-MNF 689
P+ + L+DY + R ++W L + + + + +A ++ ++I + F
Sbjct: 614 PKEMRDTLTDYQDFYRVQHGNRNVKWHHGLASAVISASFRPGCKKELIATMYQTVILLLF 673
Query: 690 QDQTSWTSKNLAAAVGIPVDALNRRMSFWISKGVVAESSGGDSSDHVYTIMESMVETKKR 749
+WT + I + + K V+A G R
Sbjct: 674 NKCETWTVAEIVEHTKI--------LEIEVVKNVLALLGG-------------------R 706
Query: 750 DSSGITQELLGGGDEEEDRAVASIENQ 776
D + Q + GGG E+++ V +++N+
Sbjct: 707 DKPKVLQRVEGGGSEKKEGTVENLKNE 733
>CUL1_DROME (Q24311) Cullin homolog 1 (Lin-19 homolog protein)
Length = 774
Score = 53.5 bits (127), Expect = 2e-06
Identities = 65/305 (21%), Positives = 121/305 (39%), Gaps = 18/305 (5%)
Query: 521 IGSKDQLVHEYRTMLAEKLLNKSDYDIDSEIRTLELLKIHFGESSLQKCEIMLNDLIGSK 580
I KD Y MLA++L+N + D+E + LK G K + M D+ SK
Sbjct: 455 IEDKDVFQKYYSKMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKLQRMFQDIGVSK 514
Query: 581 RINSNIKATISQPSQTNVEVEDNAISMDNIAATIISSNFWPPIQVEPLNLPEPVDKLLSD 640
+NS K +++ + T +E++ ++SS WP LP +++ +
Sbjct: 515 DLNSYFKQYLAEKNLT-MEID--------FGIEVLSSGSWPFQLSNNFLLPSELERSVRQ 565
Query: 641 YAKRFNEIKTPRKLQWKKSLGTVKLELQL---KDRVLQFTVAPVHASIIMNFQDQTSWTS 697
+ + + + RKL W + +L + + + S+++ F DQ S+T
Sbjct: 566 FNEFYAARHSGRKLNWLYQMCKGELIMNVNRNNSSTYTLQASTFQMSVLLQFNDQLSFTV 625
Query: 698 KNLAAAVGIPVDALNRRMSFWISKGVVAESSGGDSSDHVYTIMESMVETKKRDSSGITQE 757
+ L + L + + + V+ S +S T+ + K+ I Q
Sbjct: 626 QQLQDNTQTQQENLIQVLQILLKAKVLTSSDNENSLTPESTVELFLDYKNKKRRININQP 685
Query: 758 LLGGGDEEEDRAVASIENQLRKEMSIYEKFIMGML-----TNFGSMALDRIHNRLKVRM- 811
L E++ IE + + IM M TN S L+++ R K ++
Sbjct: 686 LKTELKVEQETVHKHIEEDRKLLIQAAIVRIMKMRKRLNHTNLISEVLNQLSTRFKPKVP 745
Query: 812 VLHQC 816
V+ +C
Sbjct: 746 VIKKC 750
>CUL1_SCHPO (O13790) Cullin 1 homolog (Cul-1) (Cell division control
53 homolog)
Length = 767
Score = 51.6 bits (122), Expect = 9e-06
Identities = 49/214 (22%), Positives = 90/214 (41%), Gaps = 17/214 (7%)
Query: 516 MIVGIIGSKDQLVHEYRTMLAEKLLNKSDYDIDSEIRTLELLKIHFGESSLQKCEIMLND 575
+I + KD + Y +LA++L+N + D+E L LK G K + M D
Sbjct: 446 IIFRYVEDKDVFQNFYTKLLAKRLVNGTSNSQDAESSMLSKLKEVCGFEYTSKLQRMFQD 505
Query: 576 LIGSKRINSNIKATISQPSQTNVEVEDNAISMDNIAATIISSNFWP--PIQVEPLNLPEP 633
+ S+ I + Q N++ +A ++ ++FWP P V +LPE
Sbjct: 506 ISLSQEITEAF-WQLPQSRAGNID----------FSALVLGTSFWPLSPNNVN-FHLPEE 553
Query: 634 VDKLLSDYAKRFNEIKTPRKLQW--KKSLGTVKLELQLKDRVLQ-FTVAPVHASIIMNFQ 690
+ L + + RKL W S G +K + + V F V+ +++ +
Sbjct: 554 LVPLYEGFQNYYYSCHNGRKLSWLFHLSKGEIKARINPQTNVTYVFQVSTYQMGVLLLYN 613
Query: 691 DQTSWTSKNLAAAVGIPVDALNRRMSFWISKGVV 724
+ S+T + LA G+ D L ++ ++ V+
Sbjct: 614 HRDSYTYEELAKITGLSTDFLTGILNIFLKAKVL 647
>CUL1_MOUSE (Q9WTX6) Cullin homolog 1 (CUL-1)
Length = 776
Score = 50.4 bits (119), Expect = 2e-05
Identities = 51/236 (21%), Positives = 96/236 (40%), Gaps = 17/236 (7%)
Query: 503 KGSRNQRKVDI------LGMIVGIIGSKDQLVHEYRTMLAEKLLNKSDYDIDSEIRTLEL 556
K S+N + ++ + ++ I KD Y MLA++L++++ D+E +
Sbjct: 432 KSSKNPEEAELEDTLNQVMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSASDDAEASMISK 491
Query: 557 LKIHFGESSLQKCEIMLNDLIGSKRINSNIKATISQPSQTNVEVEDNAISMDNIAATIIS 616
LK G K + M D+ SK +N K + TN E D S+ ++S
Sbjct: 492 LKQACGFEYTSKLQRMFQDIGVSKDLNEQFKKHL-----TNSEPLDLDFSIQ-----VLS 541
Query: 617 SNFWPPIQVEPLNLPEPVDKLLSDYAKRFNEIKTPRKLQWKKSLGTVKLELQLKDRVLQF 676
S WP Q LP +++ + + + RKL W L +L
Sbjct: 542 SGSWPFQQSCTFALPSELERSYQRFTAFYASRHSGRKLTWLYQLSKGELVTNCFKNRYTL 601
Query: 677 TVAPVHASIIMNFQDQTSWTSKNLAAAVGIPVDALNRRMSFWI-SKGVVAESSGGD 731
+ +I++ + + ++T + L + I +D L + + + SK +V E +
Sbjct: 602 QASTFQMAILLQYNTEDAYTVQQLTDSTQIKMDILAQVLQILLKSKLLVLEDENAN 657
>CUL1_HUMAN (Q13616) Cullin homolog 1 (CUL-1)
Length = 776
Score = 50.4 bits (119), Expect = 2e-05
Identities = 51/236 (21%), Positives = 96/236 (40%), Gaps = 17/236 (7%)
Query: 503 KGSRNQRKVDI------LGMIVGIIGSKDQLVHEYRTMLAEKLLNKSDYDIDSEIRTLEL 556
K S+N + ++ + ++ I KD Y MLA++L++++ D+E +
Sbjct: 432 KSSKNPEEAELEDTLNQVMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSASDDAEASMISK 491
Query: 557 LKIHFGESSLQKCEIMLNDLIGSKRINSNIKATISQPSQTNVEVEDNAISMDNIAATIIS 616
LK G K + M D+ SK +N K + TN E D S+ ++S
Sbjct: 492 LKQACGFEYTSKLQRMFQDIGVSKDLNEQFKKHL-----TNSEPLDLDFSIQ-----VLS 541
Query: 617 SNFWPPIQVEPLNLPEPVDKLLSDYAKRFNEIKTPRKLQWKKSLGTVKLELQLKDRVLQF 676
S WP Q LP +++ + + + RKL W L +L
Sbjct: 542 SGSWPFQQSCTFALPSELERSYQRFTAFYASRHSGRKLTWLYQLSKGELVTNCFKNRYTL 601
Query: 677 TVAPVHASIIMNFQDQTSWTSKNLAAAVGIPVDALNRRMSFWI-SKGVVAESSGGD 731
+ +I++ + + ++T + L + I +D L + + + SK +V E +
Sbjct: 602 QASTFQMAILLQYNTEDAYTVQQLTDSTQIKMDILAQVLQILLKSKLLVLEDENAN 657
>CUL3_CAEEL (Q17391) Cullin 3
Length = 777
Score = 48.5 bits (114), Expect = 8e-05
Identities = 48/205 (23%), Positives = 85/205 (41%), Gaps = 22/205 (10%)
Query: 475 DDDFNT---DDREAWINASRWQPDPVEA---DPLKG-------SRNQRKVDILGMIVGII 521
D DF D E ++N++R P+ V D L+ + K+D + ++ +
Sbjct: 369 DRDFKNRFQHDFETFLNSNRQSPEFVALYMDDMLRSGLKCVSDAEMDNKLDNVMILFRYL 428
Query: 522 GSKDQLVHEYRTMLAEKLLNKSDYDIDSEIRTLELLKIHFGESSLQKCEIMLNDLIGSKR 581
KD ++ LA++LL D E L LK G QK E M D
Sbjct: 429 QEKDVFEKYFKQYLAKRLLLDKSCSDDVEKALLAKLKTECGCQFTQKLENMFRD------ 482
Query: 582 INSNIKATISQPSQTNVEVEDNAISMDNIAATIISSNFWPPIQVEPLNLPEPVDKLLSDY 641
+ T++ + E + +S+D I+ ++++ WP +Q P+ LP+ + +
Sbjct: 483 --KELWLTLATSFRDWREAQPTKMSID-ISLRVLTAGVWPTVQCNPVVLPQELSVAYEMF 539
Query: 642 AKRFNEIKTPRKLQWKKSLGTVKLE 666
+ + E T RKL LG ++
Sbjct: 540 TQYYTEKHTGRKLTINTLLGNADVK 564
>CUL3_YEAST (P53202) Cullin B (Cullin 3)
Length = 744
Score = 48.1 bits (113), Expect = 1e-04
Identities = 42/199 (21%), Positives = 86/199 (43%), Gaps = 20/199 (10%)
Query: 517 IVGIIGSKDQLVHEYRTMLAEKLLNKSDYDIDSEIRTLELLKIHFGESSLQKCEIMLNDL 576
++G++ KD Y+ L+ +LL + ++ E ++++K G K EIML D+
Sbjct: 419 LIGLLTEKDIFEKIYKKQLSRRLLQQRSL-VEIEKWMVQMIKKVLGTFFTSKLEIMLRDI 477
Query: 577 -IGSKRINSNIKATISQPSQTNVEVEDNAISMDNIAATIISSNFWP-----PIQVEPLNL 630
+ S+ + +TI N+I + A +++ WP PI E ++L
Sbjct: 478 SLSSEMYQAFQHSTI------------NSIEYLSFAPQVLTRTSWPFQSTNPID-EGISL 524
Query: 631 PEPVDKLLSDYAKRFNEIKTPRKLQWKKSLGTVKLELQLKDRVLQFTVAPVHASIIMNFQ 690
P + ++L+ + ++ R L+W L +++ Q + + + I + F+
Sbjct: 525 PPRMSQILAGFEGYYSLKYKERVLKWAHHLSVIEIGCQFNSGYYEISFSVYAGVIFLLFE 584
Query: 691 DQTSWTSKNLAAAVGIPVD 709
D T + IP+D
Sbjct: 585 DYEELTLGEIYELTHIPID 603
>CUL2_CAEEL (Q17390) Cullin 2
Length = 776
Score = 46.2 bits (108), Expect = 4e-04
Identities = 61/276 (22%), Positives = 110/276 (39%), Gaps = 15/276 (5%)
Query: 508 QRKVDILGMIVGIIGSKDQLVHEYRTMLAEKLLNKSDYDIDSEIRTLELLKIHFGESSLQ 567
+ K+D +I I KD Y MLA +L+ + +D+E + LK G
Sbjct: 429 EAKLDSAIVIFRYIEDKDIFQKFYSKMLANRLIASTSISMDAEELMINKLKQACGYEFTS 488
Query: 568 KCEIMLNDLIGSKRINSNIKATIS-----QPSQTNVEVEDNAISMD----NIAATIISSN 618
K M D+ S+ +++N I+ QP V + + N +SN
Sbjct: 489 KLSRMFTDIGLSQELSNNFDKHIADIKTVQPDVKFVPTQTMILQAGSWPLNAPQLSTNSN 548
Query: 619 FWPPIQVEPLNLPEPVDKLLSDYAKRFNEIKTPRKLQW--KKSLGTVKLELQLKDRVLQF 676
V +LP + ++ ++ K + RKL W S G V+L K V Q
Sbjct: 549 NQTAQDVANFHLPRILQPVIQEFEKFYTGKHNGRKLTWLFNMSQGDVRLTYLDKQYVAQM 608
Query: 677 TVAPVHASIIMNFQDQTSWTSKNLAAAVGIPVDALNRRMSFWISKGVVAESSGGDSSDHV 736
V + A ++ F+ + + K++ +G+ D L + + + ++ ++D +
Sbjct: 609 YVYQMAA--LLCFERRDAILVKDIGEEIGVSGDYLLKTIRTILDVTLLTCDDQNLTADSL 666
Query: 737 YTIMESMVETKKRDSSGITQELLGGGDEEEDRAVAS 772
+ SM T KR + + E+E AVA+
Sbjct: 667 VRLNMSM--TSKRMKFRLQAPQVNKAVEKEQEAVAN 700
>CUL4_SCHPO (O14122) Cullin 4 homolog (Cul-4)
Length = 734
Score = 45.4 bits (106), Expect = 7e-04
Identities = 36/173 (20%), Positives = 74/173 (41%), Gaps = 15/173 (8%)
Query: 521 IGSKDQLVHEYRTMLAEKLLNKSDYDIDSEIRTLELLKIHFGESSLQKCEIMLNDLIGSK 580
I SKD Y+ +A++LL +E+ L++LK G E M D+ SK
Sbjct: 417 IASKDIFEAYYKLDIAKRLLLNKSASAQNELMLLDMLKKTCGSQFTHSLEGMFRDVNISK 476
Query: 581 RINSNIKATISQPSQTNVEVEDNAISMDNIAATIISSNFWPPIQVEPLNLPEPVDKLLSD 640
S+ + + + + ++ ++S +WP + LP+ + + L
Sbjct: 477 EFTSSFRHSKAAHNLHR-----------DLYVNVLSQAYWPSYPESHIRLPDDMQQDLDC 525
Query: 641 YAKRFNEIKTPRKLQWKKSLG--TVKLELQLKDRVLQFTVAPVHASIIMNFQD 691
+ K + + +K+ W SLG VK L ++ + +++ A +++ F +
Sbjct: 526 FEKFYLSKQVGKKISWYASLGHCIVKARFPLGNK--ELSISLFQACVLLQFNN 576
>CUL2_HUMAN (Q13617) Cullin homolog 2 (CUL-2)
Length = 745
Score = 44.3 bits (103), Expect = 0.001
Identities = 44/257 (17%), Positives = 104/257 (40%), Gaps = 11/257 (4%)
Query: 521 IGSKDQLVHEYRTMLAEKLLNKSDYDIDSEIRTLELLKIHFGESSLQKCEIMLNDLIGSK 580
I KD Y MLA++L++ +DSE + LK G K M D+
Sbjct: 425 IDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDM---- 480
Query: 581 RINSNIKATISQPSQTNVEVEDNAISMD-NIAATIISSNFWPPIQV--EPLNLPEPVDKL 637
++ A ++ ++ +D I + + ++ + WP Q +P+ ++K
Sbjct: 481 ----SVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKS 536
Query: 638 LSDYAKRFNEIKTPRKLQWKKSLGTVKLELQLKDRVLQFTVAPVHASIIMNFQDQTSWTS 697
+ + +++ + RKL W L T ++++ + V ++++ F + + +
Sbjct: 537 VQMFELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSY 596
Query: 698 KNLAAAVGIPVDALNRRMSFWISKGVVAESSGGDSSDHVYTIMESMVETKKRDSSGITQE 757
K L + + L + + + ++ S + D + +M + KR IT
Sbjct: 597 KELQDSTQMNEKELTKTIKSLLDVKMINHDSEKEDIDAESSFSLNMNFSSKRTKFKITTS 656
Query: 758 LLGGGDEEEDRAVASIE 774
+ +E ++ ++++
Sbjct: 657 MQKDTPQEMEQTRSAVD 673
>CUL2_MOUSE (Q9D4H8) Cullin homolog 2 (CUL-2)
Length = 745
Score = 43.9 bits (102), Expect = 0.002
Identities = 44/257 (17%), Positives = 103/257 (39%), Gaps = 11/257 (4%)
Query: 521 IGSKDQLVHEYRTMLAEKLLNKSDYDIDSEIRTLELLKIHFGESSLQKCEIMLNDLIGSK 580
I KD Y MLA++L++ +DSE + LK G K M D+
Sbjct: 425 IDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDM---- 480
Query: 581 RINSNIKATISQPSQTNVEVEDNAISMD-NIAATIISSNFWPPIQV--EPLNLPEPVDKL 637
++ A ++ + +D I + + ++ + WP Q +P+ ++K
Sbjct: 481 ----SVSADLNNKFNNFIRNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKS 536
Query: 638 LSDYAKRFNEIKTPRKLQWKKSLGTVKLELQLKDRVLQFTVAPVHASIIMNFQDQTSWTS 697
+ + +++ + RKL W L T ++++ + V ++++ F + + +
Sbjct: 537 VQMFELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSY 596
Query: 698 KNLAAAVGIPVDALNRRMSFWISKGVVAESSGGDSSDHVYTIMESMVETKKRDSSGITQE 757
K L + + L + + + ++ S + D + +M + KR IT
Sbjct: 597 KELQDSTQMNEKELTKTIKSLLDVKMINHDSEKEDIDAESSFSLNMSFSSKRTKFKITTS 656
Query: 758 LLGGGDEEEDRAVASIE 774
+ +E ++ ++++
Sbjct: 657 MQKDTPQELEQTRSAVD 673
>CUL6_CAEEL (Q21346) Cullin 6
Length = 729
Score = 42.0 bits (97), Expect = 0.007
Identities = 36/188 (19%), Positives = 76/188 (40%), Gaps = 13/188 (6%)
Query: 517 IVGIIGSKDQLVHEYRTMLAEKLLNKSDYDIDSEIRTLELLKIHFGESSLQKCEIMLNDL 576
++ I KD Y+ +E+++N S D+E + + L G + M+ D
Sbjct: 408 VLKYISEKDVFQLYYQNWFSERIINNSSASDDAEEKFITNLTATEGLEYTRNLVKMVEDA 467
Query: 577 IGSKRINSNIKATISQPSQTNVEVEDNAISMDNIAATIISSNFWPPIQVEPLNLPEPVDK 636
SK + + K +T ++ N I + ++ WP + + LP +
Sbjct: 468 KISKDLTTEFKDI-----KTEKSIDFNVI--------LQTTGAWPSLDQIKIILPRELST 514
Query: 637 LLSDYAKRFNEIKTPRKLQWKKSLGTVKLELQLKDRVLQFTVAPVHASIIMNFQDQTSWT 696
+L ++ +N R+L W S ++ + ++ F V + F +Q S+T
Sbjct: 515 ILKEFDTFYNASHNGRRLNWAYSQCRGEVNSKAFEKKYVFIVTASQLCTLYLFNEQDSFT 574
Query: 697 SKNLAAAV 704
+ ++ A+
Sbjct: 575 IEQISKAI 582
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.318 0.135 0.391
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 105,019,402
Number of Sequences: 164201
Number of extensions: 4555238
Number of successful extensions: 12439
Number of sequences better than 10.0: 37
Number of HSP's better than 10.0 without gapping: 15
Number of HSP's successfully gapped in prelim test: 22
Number of HSP's that attempted gapping in prelim test: 12383
Number of HSP's gapped (non-prelim): 53
length of query: 889
length of database: 59,974,054
effective HSP length: 119
effective length of query: 770
effective length of database: 40,434,135
effective search space: 31134283950
effective search space used: 31134283950
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 70 (31.6 bits)
Lotus: description of TM0252b.3