BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= TM0218.20
(631 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
SBN1_MOUSE (Q8R4Y4) Stabilin 1 precursor (FEEL-1 protein) 68 8e-11
SBN1_HUMAN (Q9NY15) Stabilin 1 precursor (FEEL-1 protein) (MS-1 ... 64 1e-09
FBN1_MOUSE (Q61554) Fibrillin 1 precursor 63 2e-09
FBN1_HUMAN (P35555) Fibrillin 1 precursor 63 3e-09
GAS6_HUMAN (Q14393) Growth-arrest-specific protein 6 precursor (... 62 3e-09
FBN1_BOVIN (P98133) Fibrillin 1 precursor (MP340) 62 3e-09
GAS6_RAT (Q63772) Growth-arrest-specific protein 6 precursor (GA... 61 1e-08
UROM_RAT (P27590) Uromodulin precursor (Tamm-Horsfall urinary gl... 60 1e-08
FBN3_HUMAN (Q75N90) Fibrillin 3 precursor 60 1e-08
EFL3_HUMAN (O75095) Multiple EGF-like-domain protein 3 (Multiple... 60 1e-08
FBN1_PIG (Q9TV36) Fibrillin 1 precursor 60 2e-08
LTB4_MOUSE (Q8K4G1) Latent transforming growth factor beta bindi... 59 3e-08
UROM_BOVIN (P48733) Uromodulin precursor (Tamm-Horsfall urinary ... 59 4e-08
FBN2_MOUSE (Q61555) Fibrillin 2 precursor 59 4e-08
FBN2_HUMAN (P35556) Fibrillin 2 precursor 59 4e-08
LTBS_HUMAN (P22064) Latent transforming growth factor beta bindi... 59 5e-08
LTBL_HUMAN (Q14766) Latent transforming growth factor beta bindi... 59 5e-08
GAS6_MOUSE (Q61592) Growth-arrest-specific protein 6 precursor (... 58 7e-08
EGF_HUMAN (P01133) Pro-epidermal growth factor precursor (EGF) [... 58 7e-08
EGF_RAT (P07522) Pro-epidermal growth factor precursor (EGF) [Co... 57 1e-07
>SBN1_MOUSE (Q8R4Y4) Stabilin 1 precursor (FEEL-1 protein)
Length = 2571
Score = 67.8 bits (164), Expect = 8e-11
Identities = 50/163 (30%), Positives = 72/163 (43%), Gaps = 22/163 (13%)
Query: 418 ETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGYTTCEASGPGRCKI 477
E + C +GGC AN T K R C C DG + GDG E + C +
Sbjct: 1456 EVDPCASGHGGC--SPYANCT--KVAPGQRTCTCQ--DG--YTGDGELCQEINS---CLV 1504
Query: 478 KNGGCWHEARNGHAFSACVDDG--EVKCQCPAGFKGDGVKNCQDVDECKEKKACQCPECS 535
NGGC H + C+ G +V C C G+ GDG++ C+ +D C + P
Sbjct: 1505 HNGGC-------HVHAECIPTGPQQVSCSCREGYSGDGIQTCKLLDPCSQNNGGCSPYAV 1557
Query: 536 CKNTW-GSYDCSCSGDLLYIRDHDTCISKTASQGGRSAWAAFW 577
CK+T G CSC + D TC + + R+ +A+F+
Sbjct: 1558 CKSTGDGQRTCSCDATHT-VGDGITCHGRVGLELLRNKYASFF 1599
Score = 44.7 bits (104), Expect = 8e-04
Identities = 38/114 (33%), Positives = 48/114 (41%), Gaps = 19/114 (16%)
Query: 417 VETNEC-LENNGGCWKDKAANITACKDTFRGRV-CECPLVDGVQFKGDGYTTCEASGPGR 474
V +EC L+ GGC D C G+ C C L F G+GY E S
Sbjct: 904 VAIDECGLDTRGGCHAD-----ALCSYVGPGQSRCTCKL----GFAGNGY---ECSPIDP 951
Query: 475 CKIKNGGCWHEARNGHAFSACVDDGEVKCQCPAGFKGDGVKNCQDVDECKEKKA 528
C++ NGGC +G A V G+ C CP F GDG D+ + E A
Sbjct: 952 CRVGNGGC-----HGLATCKAVGGGQRVCTCPPHFGGDGFSCYGDIIQELEANA 1000
Score = 42.7 bits (99), Expect = 0.003
Identities = 44/151 (29%), Positives = 62/151 (40%), Gaps = 24/151 (15%)
Query: 426 NGGCWKDKAANITACKDTFRGR-------VCECP---LVDGVQFKGDGYTTCEASGPG-R 474
NG C + + TAC+ GR VC+C +G+ +G+G C A G R
Sbjct: 1354 NGECRCQEGFHGTACEMCELGRYGPTCSGVCDCDHGLCQEGL--RGNGSCVCHAGWQGLR 1411
Query: 475 C--KIKNGGCWHEARNGHAFSACVDD--GEVKCQCPAGFKGDGVKNCQDVDECKEKKACQ 530
C KI + C + + C+ D G C C AG+ G+G C +VD C
Sbjct: 1412 CDQKITDHQC---PKKCDPNANCIQDSAGIPACVCAAGYSGNG-SYCSEVDPCASGHGGC 1467
Query: 531 CPECSC-KNTWGSYDCSCSGDLLYIRDHDTC 560
P +C K G C+C Y D + C
Sbjct: 1468 SPYANCTKVAPGQRTCTCQDG--YTGDGELC 1496
Score = 41.6 bits (96), Expect = 0.006
Identities = 29/98 (29%), Positives = 43/98 (43%), Gaps = 16/98 (16%)
Query: 470 SGPGRCKIKNGGCWHEARNG-HAFSAC--VDDGEVKCQCPAGFKGDGVKNCQDVDECKEK 526
SG GR + C + R G HA + C V G+ +C C GF G+G + C +D C+
Sbjct: 897 SGDGRICVAIDECGLDTRGGCHADALCSYVGPGQSRCTCKLGFAGNGYE-CSPIDPCRVG 955
Query: 527 KA-------CQCPE-----CSCKNTWGSYDCSCSGDLL 552
C+ C+C +G SC GD++
Sbjct: 956 NGGCHGLATCKAVGGGQRVCTCPPHFGGDGFSCYGDII 993
Score = 35.4 bits (80), Expect = 0.46
Identities = 62/243 (25%), Positives = 75/243 (30%), Gaps = 85/243 (34%)
Query: 392 KGAVMKAICSG------FEETTEPAVCLSSDVETNECLENNGGCWKDKAANITACKDTFR 445
K V KA C G FE PA S + +E NG C C+ F
Sbjct: 94 KDVVQKACCPGYWGSQCFECPGGPATPCSGHGTCLDGIEGNGTC---------VCQGNFS 144
Query: 446 GRVCE---------------CPLVDGVQF---KGDGYTTCEASGPG-------------R 474
G VC+ C V GV +GDG C A G +
Sbjct: 145 GSVCQECRDPNRFGPDCQSVCNCVHGVCSHGPRGDGSCRCFAGYTGPHCDQELPVCQSLK 204
Query: 475 CKIKNGGCWHEARNGHAF------------------SAC--------VDDGEVKCQCPAG 508
C +N C EA SAC G+ +CQCP
Sbjct: 205 CP-QNSQCSAEAPTCKCLPGYTQQDNVCLAPDPCQPSACSPLARCSVTPQGQAQCQCPEN 263
Query: 509 FKGDGVKNCQDVDECKEKKACQCPECSCKNTW---GSYDCSCSGDLLYIRDHDTCISKTA 565
+ GDG K C D C CP S + G C C R T I+ A
Sbjct: 264 YHGDG-KVCLPRDPCLTNFG-GCPSNSTFCLYRGPGKATCMC-------RPGMTSINNNA 314
Query: 566 SQG 568
S+G
Sbjct: 315 SEG 317
Score = 35.0 bits (79), Expect = 0.60
Identities = 35/117 (29%), Positives = 51/117 (42%), Gaps = 24/117 (20%)
Query: 411 VCLSSDVETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGYTTCEAS 470
VC +D+ C + +GGC K AN C C C L D ++GDG++ C A
Sbjct: 2088 VCTVADL----CQKGHGGC--SKHAN---CSQVGTVVTCTC-LPD---YEGDGWS-CRAR 2133
Query: 471 GPGRCKIKNGGCWHEARNGHAFSACVDDGEVKCQCPAGFKGDGVKNCQD----VDEC 523
P GGC + HA +C+C G+ GDG++ ++ VD C
Sbjct: 2134 DPC-LDGHRGGC-----SEHADCLNTGPNTRRCECHVGYVGDGLQCLEELEPPVDRC 2184
Score = 33.9 bits (76), Expect = 1.3
Identities = 43/152 (28%), Positives = 61/152 (39%), Gaps = 27/152 (17%)
Query: 423 LENNGGC-----WKDKAANITACKDTFR-GRVCE--CPLVDGVQFKGDG------YTTCE 468
+ NG C +K A +I C D + G C+ C V G+ G TC
Sbjct: 751 VRGNGACLCFPDYKGIACHI--CSDPKKHGEQCQEDCGCVHGLCDNRPGSGGVCQQGTCA 808
Query: 469 ASGPGR-CKIKNGGCWHE--ARNGHAFSACV-DDGEVKCQCPAGFKGDGVKNCQDVDECK 524
GR C G C A+ H+ + CV +G +C C GF+G+G +C+ + C
Sbjct: 809 PGFQGRFCNESMGNCGSTGLAQPCHSDAHCVIQEGVARCVCHDGFEGNGF-SCKRSNPCS 867
Query: 525 EKKACQCPE-CSC-KNTWGSYDCSC----SGD 550
C E C G++ C C SGD
Sbjct: 868 RPDRGGCSENAECVPGDLGTHHCICHKGWSGD 899
Score = 32.0 bits (71), Expect = 5.1
Identities = 12/23 (52%), Positives = 14/23 (60%)
Query: 495 CVDDGEVKCQCPAGFKGDGVKNC 517
C +V CQC AGF GDG+ C
Sbjct: 2299 CYRVQDVACQCRAGFVGDGISTC 2321
Score = 31.6 bits (70), Expect = 6.6
Identities = 21/76 (27%), Positives = 31/76 (40%), Gaps = 7/76 (9%)
Query: 503 CQCPAGFKGDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSC----SGDLLYIRDHD 558
C+C G++GDG + C D C++ +C C+C GD R D
Sbjct: 2076 CECSLGYEGDG-RVCTVADLCQKGHGGCSKHANCSQVGTVVTCTCLPDYEGDGWSCRARD 2134
Query: 559 TCISKTASQGGRSAWA 574
C+ +GG S A
Sbjct: 2135 PCLD--GHRGGCSEHA 2148
>SBN1_HUMAN (Q9NY15) Stabilin 1 precursor (FEEL-1 protein) (MS-1
antigen)
Length = 2570
Score = 63.9 bits (154), Expect = 1e-09
Identities = 49/163 (30%), Positives = 74/163 (45%), Gaps = 22/163 (13%)
Query: 418 ETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGYTTCEASGPGRCKI 477
E + C +GGC AN T K R C C DG + GDG E + C I
Sbjct: 1455 EVDPCAHGHGGC--SPHANCT--KVAPGQRTCTCQ--DG--YMGDGELCQEINS---CLI 1503
Query: 478 KNGGCWHEARNGHAFSACVDDG--EVKCQCPAGFKGDGVKNCQDVDECKEKKACQCPECS 535
+GGC H + C+ G +V C C G+ GDG++ C+ +D C + P +
Sbjct: 1504 HHGGC-------HIHAECIPTGPQQVSCSCREGYSGDGIRTCELLDPCSKNNGGCSPYAT 1556
Query: 536 CKNTWGSYDCSCSGDLLY-IRDHDTCISKTASQGGRSAWAAFW 577
CK+T G +C+ D + + D TC ++ + R A+F+
Sbjct: 1557 CKST-GDGQRTCTCDTAHTVGDGLTCRARVGLELLRDKHASFF 1598
Score = 47.4 bits (111), Expect = 1e-04
Identities = 46/151 (30%), Positives = 63/151 (41%), Gaps = 24/151 (15%)
Query: 426 NGGCWKDKAANITACKDTFRGR-------VCECP---LVDGVQFKGDGYTTCEASGPG-R 474
+G C + + TAC+ GR VC+C +G+Q GDG C G R
Sbjct: 1353 SGECHCHEGFHGTACEVCELGRYGPNCTGVCDCAHGLCQEGLQ--GDGSCVCNVGWQGLR 1410
Query: 475 C--KIKNGGCWHEARNGHAFSACVDD--GEVKCQCPAGFKGDGVKNCQDVDECKEKKACQ 530
C KI + C R + CV D G C C AG+ G+G+ C +VD C
Sbjct: 1411 CDQKITSPQC---PRKCDPNANCVQDSAGASTCACAAGYSGNGI-FCSEVDPCAHGHGGC 1466
Query: 531 CPECSC-KNTWGSYDCSCSGDLLYIRDHDTC 560
P +C K G C+C Y+ D + C
Sbjct: 1467 SPHANCTKVAPGQRTCTCQDG--YMGDGELC 1495
Score = 46.6 bits (109), Expect = 2e-04
Identities = 40/112 (35%), Positives = 48/112 (42%), Gaps = 23/112 (20%)
Query: 411 VCLSSDVETNEC-LENNGGCWKDKAANITACKDTFRGRV-CECPLVDGVQFKGDGYTTCE 468
VC++ D EC L+ GGC D C G+ C C L F GDGY C
Sbjct: 901 VCVAID----ECELDVRGGCHTD-----ALCSYVGPGQSRCTCKL----GFAGDGYQ-CS 946
Query: 469 ASGPGRCKIKNGGCWHEARNGHAFSACVDDGEVKCQCPAGFKGDGVKNCQDV 520
P C+ NGGC +G A V G+ C CP GF GDG D+
Sbjct: 947 PIDP--CRAGNGGC-----HGLATCRAVGGGQRVCTCPPGFGGDGFSCYGDI 991
Score = 38.5 bits (88), Expect = 0.054
Identities = 30/95 (31%), Positives = 43/95 (44%), Gaps = 11/95 (11%)
Query: 466 TCEASGPGR-CKIKNGGCWHE--ARNGHAFSACVD-DGEVKCQCPAGFKGDGVKNCQDVD 521
TC GR C G C A++ H + CV +G +C+C GF+GDG +C +
Sbjct: 805 TCAPGFSGRFCNESMGDCGPTGLAQHCHLHARCVSQEGVARCRCLDGFEGDGF-SCTPSN 863
Query: 522 ECKEKKACQCPE-CSC-KNTWGSYDCSC----SGD 550
C C E C + G++ C+C SGD
Sbjct: 864 PCSHPDRGGCSENAECVPGSLGTHHCTCHKGWSGD 898
Score = 37.7 bits (86), Expect = 0.092
Identities = 37/127 (29%), Positives = 58/127 (45%), Gaps = 26/127 (20%)
Query: 411 VCLSSDVETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGYTTCEAS 470
VC +D+ C + +GGC + AN C C C L D ++GDG++ C A
Sbjct: 2088 VCTVADL----CQDGHGGC--SEHAN---CSQVGTMVTCTC-LPD---YEGDGWS-CRAR 2133
Query: 471 GPGRCKIKN-GGCWHEARNGHAFSACVDDG--EVKCQCPAGFKGDGVKNCQDVDECKEKK 527
P C + GGC A C+ G +C+C AG+ GDG++ ++ + ++
Sbjct: 2134 NP--CTDGHRGGCSEHAN-------CLSTGLNTRRCECHAGYVGDGLQCLEESEPPVDRC 2184
Query: 528 ACQCPEC 534
Q P C
Sbjct: 2185 LGQPPPC 2191
Score = 35.0 bits (79), Expect = 0.60
Identities = 52/232 (22%), Positives = 71/232 (30%), Gaps = 68/232 (29%)
Query: 387 RGKLEKGAVMKAICSGFEETTEPAVCLSSDVETNECLENNGGCWKDKAANITA-CKDTFR 445
R K K V KA C G+ + C +G C N T C++ FR
Sbjct: 88 RRKCRKQVVQKACCPGYWGSR----CHECPGGAETPCNGHGTCLDGMDRNGTCVCQENFR 143
Query: 446 GRVCE---------------CPLVDGVQF---KGDGY----------------------- 464
G C+ C V GV +GDG
Sbjct: 144 GSACQECQDPNRFGPDCQSVCSCVHGVCNHGPRGDGSCLCFAGYTGPHCDQELPVCQELR 203
Query: 465 ----TTCEASGPG------------RCKIKNGGCWHEARNGHAFSACVDDGEVKCQCPAG 508
T C A P C+ N CW + A + G+ +C CP
Sbjct: 204 CPQNTQCSAEAPSCRCLPGYTQQGSECRAPNP-CWPSPCSLLAQCSVSPKGQAQCHCPEN 262
Query: 509 FKGDGVKNCQDVDECKEKKACQCPECSCKNTW---GSYDCSCSGDLLYIRDH 557
+ GDG+ C D C + CP S + G C+C L+ I +
Sbjct: 263 YHGDGMV-CLPKDPCTDNLG-GCPSNSTLCVYQKPGQAFCTCRPGLVSINSN 312
Score = 32.0 bits (71), Expect = 5.1
Identities = 36/140 (25%), Positives = 55/140 (38%), Gaps = 29/140 (20%)
Query: 439 ACKDTFRGRVCECPLVDGVQFKGDGYTTCEASGPGRCKIK-------NGGCWHEA--RNG 489
AC+ T GR E G F +G+T GP RC+++ C EA R G
Sbjct: 2020 ACRCTVHGRCDEGLGGSGSCFCDEGWT-----GP-RCEVQLELQPVCTPPCAPEAVCRAG 2073
Query: 490 HAFSACVDDGEVKCQCPAGFKGDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSG 549
++ C+C G++GDG + C D C++ +C C+C
Sbjct: 2074 NS-----------CECSLGYEGDG-RVCTVADLCQDGHGGCSEHANCSQVGTMVTCTCLP 2121
Query: 550 DLLYIRDHDTCISKTASQGG 569
D Y D +C ++ G
Sbjct: 2122 D--YEGDGWSCRARNPCTDG 2139
>FBN1_MOUSE (Q61554) Fibrillin 1 precursor
Length = 2871
Score = 63.2 bits (152), Expect = 2e-09
Identities = 59/201 (29%), Positives = 76/201 (37%), Gaps = 41/201 (20%)
Query: 397 KAIC-SGFEETTEPAVCLSSDVETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVD 455
+ +C GF + + C V+ NEC N C C++T +C C +
Sbjct: 1262 RCLCYDGFMASEDMKTC----VDVNECDLNPNICLSG------TCENTKGSFICHCDM-- 1309
Query: 456 GVQFKGDGYTTCEASGPGRCKIKNGGCWHEARNGHAFSACVDD-GEVKCQCPAGFKGDGV 514
G K G T C + C+I C A C + G KC C G+ GDG+
Sbjct: 1310 GYSGK-KGKTGC--TDINECEIGAHNCGRHA-------VCTNTAGSFKCSCSPGWIGDGI 1359
Query: 515 KNCQDVDECKEKKACQCPECSCKNTWGSYDCSC----SGDLLYIRDHDTCISKTASQGGR 570
K C D+DEC CKNT GSY C C +GD D D C G
Sbjct: 1360 K-CTDLDECSNGTHMCSQHADCKNTMGSYRCLCKDGYTGDGFTCTDLDECSENLNLCGN- 1417
Query: 571 SAWAAFWVIIAGLVLSAGGGY 591
G L+A GGY
Sbjct: 1418 -----------GQCLNAPGGY 1427
Score = 53.1 bits (126), Expect = 2e-06
Identities = 50/167 (29%), Positives = 69/167 (40%), Gaps = 38/167 (22%)
Query: 420 NECLENNGG-CWKDKAANITACKDTFRGRV----------------CE-CPLVDGVQFK- 460
+ECL+N G C+ + N+ + R V CE CP V +K
Sbjct: 2329 DECLDNREGYCFSEVFENMCQIGSSNRNPVTKSECCCVGGRGWGLHCEICPFEGTVAYKK 2388
Query: 461 ----GDGYTTCEASGPGRCKIKNGGCWHEARNGHAFSACVDD-GEVKCQCPAGFKGDGV- 514
G G+ T + CK+ + C RNG CV+D G C C G+ D
Sbjct: 2389 LCPHGRGFMT-NGADVDECKVIHDVC----RNGE----CVNDRGSYHCICKTGYTPDITG 2439
Query: 515 KNCQDVDECKEK-KACQCPECSCKNTWGSYDCSCSGDLLYIRDHDTC 560
+C D++EC + K C CKNT GSY CSC + D +C
Sbjct: 2440 TSCVDLNECNQAPKPCNF---ICKNTEGSYQCSCPNGYILQEDGRSC 2483
Score = 51.6 bits (122), Expect = 6e-06
Identities = 45/159 (28%), Positives = 65/159 (40%), Gaps = 29/159 (18%)
Query: 417 VETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGYTTCE-----ASG 471
+E NEC++ + + N T CK+ G C C +G F+ TCE A
Sbjct: 2159 LEGNECVDTDECSVGNPCGNGT-CKNVIGGFECTCE--EG--FEPGPMMTCEDINECAQN 2213
Query: 472 PGRCKIKNGGCWHEARNGHAFSACVDD-GEVKCQCPAGFK-GDGVKNCQDVDECKE-KKA 528
P C + CV+ G +C+CP G+ + + C+D DEC E K
Sbjct: 2214 PLLCAFR----------------CVNTYGSYECKCPVGYVLREDRRMCKDEDECAEGKHD 2257
Query: 529 CQCPECSCKNTWGSYDCSCSGDLLYIRDHDTCISKTASQ 567
C + CKN G+Y C C D + CI + Q
Sbjct: 2258 CTEKQMECKNLIGTYMCICGPGYQRRPDGEGCIDENECQ 2296
Score = 50.1 bits (118), Expect = 2e-05
Identities = 48/164 (29%), Positives = 62/164 (37%), Gaps = 30/164 (18%)
Query: 401 SGFEETTEPAVCLSSDVETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFK 460
+G++ T C D ECL+N C N C +T C C V +
Sbjct: 517 AGYQSTLTRTECRDID----ECLQNGRIC------NNGRCINTDGSFHCVCNAGFHVSSE 566
Query: 461 GDGYTTC-EASGPGRCKIKNGGCWHEARNGHAFSACVDDGEVKCQCPAGFK--GDGVKNC 517
G E P C NG C +E DG KC C GF+ DG + C
Sbjct: 567 GKNCEDMDECRTPNMCP--NGMCINE------------DGSFKCICKPGFQLASDG-RYC 611
Query: 518 QDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDHDTCI 561
+D++EC+ C C NT GSY C C L D C+
Sbjct: 612 KDINECETPGICM--NGRCVNTDGSYRCECFPGLAVGLDGRWCV 653
Score = 48.9 bits (115), Expect = 4e-05
Identities = 30/85 (35%), Positives = 41/85 (47%), Gaps = 12/85 (14%)
Query: 495 CVD-DGEVKCQCPAGF--KGDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSC---- 547
C++ DG C C AGF +G KNC+D+DEC+ CP C N GS+ C C
Sbjct: 546 CINTDGSFHCVCNAGFHVSSEG-KNCEDMDECRTPN--MCPNGMCINEDGSFKCICKPGF 602
Query: 548 --SGDLLYIRDHDTCISKTASQGGR 570
+ D Y +D + C + GR
Sbjct: 603 QLASDGRYCKDINECETPGICMNGR 627
Score = 48.9 bits (115), Expect = 4e-05
Identities = 44/143 (30%), Positives = 56/143 (38%), Gaps = 38/143 (26%)
Query: 440 CKDTFRGRVCECPLVDGVQFKGDGYTTCEAS---------GPGRCKIKNGGCWHEARNGH 490
CK+T C C DG + GDG+T + G G+C GG E G
Sbjct: 1380 CKNTMGSYRCLCK--DG--YTGDGFTCTDLDECSENLNLCGNGQCLNAPGGYRCECDMGF 1435
Query: 491 AFSA----CVD------------------DGEVKCQCPAGFKGD-GVKNCQDVDECKEKK 527
SA C D G +C+C G++ D NC DV+EC +
Sbjct: 1436 VPSADGKACEDIDECSLPNICVFGTCHNLPGLFRCECEIGYELDRSGGNCTDVNECLDPT 1495
Query: 528 ACQCPECSCKNTWGSYDCSCSGD 550
C +C NT GSY C CS D
Sbjct: 1496 TCISG--NCVNTPGSYTCDCSPD 1516
Score = 48.9 bits (115), Expect = 4e-05
Identities = 36/126 (28%), Positives = 51/126 (39%), Gaps = 19/126 (15%)
Query: 440 CKDTFRGRVCECPLVDGVQFKGDGYTTCEASGPGRCKIKNGGCWHEARNGHAFSACVDD- 498
C +T G C+CP G+T + C I N C + + C +
Sbjct: 2500 CVNTIGGFTCKCP---------PGFTQHHTA----C-IDNNECTSDINLCGSKGICQNTP 2545
Query: 499 GEVKCQCPAGFKGD-GVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDH 557
G C+C GF D +C+DVDEC+ CQ C+N G Y CSC L
Sbjct: 2546 GSFTCECQRGFSLDQSGASCEDVDECEGNHRCQH---GCQNIIGGYRCSCPQGYLQHYQW 2602
Query: 558 DTCISK 563
+ C+ +
Sbjct: 2603 NQCVDE 2608
Score = 48.5 bits (114), Expect = 5e-05
Identities = 27/88 (30%), Positives = 36/88 (40%), Gaps = 10/88 (11%)
Query: 475 CKIKNGGCWHEARNGHAFSACVDDGEVKCQCPAGFK-GDGVKNCQDVDECKEKKACQCPE 533
C I NGGC N DG +C C GF ++C D+D+C++ C
Sbjct: 1201 CSIMNGGCETFCTNS--------DGSYECSCQPGFALMPDQRSCTDIDQCEDNPNI-CDG 1251
Query: 534 CSCKNTWGSYDCSCSGDLLYIRDHDTCI 561
C N G Y C C + D TC+
Sbjct: 1252 GQCTNIPGEYRCLCYDGFMASEDMKTCV 1279
Score = 47.8 bits (112), Expect = 9e-05
Identities = 48/178 (26%), Positives = 68/178 (37%), Gaps = 46/178 (25%)
Query: 417 VETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGYTTCE-------- 468
V+ +EC E G C N+ +FR CECP+ F D CE
Sbjct: 1765 VDIDECREIPGVCENGVCINMVG---SFR---CECPVGF---FYNDKLLVCEDIDECQNG 1815
Query: 469 -----------ASGPGRCKIK-------NGGC-----WHEARNGHAFSACVDD-GEVKCQ 504
+G RC K G C E N + C+D G C
Sbjct: 1816 PVCLRNAECINTAGSYRCDCKPGYRLTSTGQCNDRNECQEIPNICSHGQCIDTVGSFYCL 1875
Query: 505 CPAGFK-GDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDHDTCI 561
C GFK + C D++EC+ C +C+NT GS++C C+ + ++D CI
Sbjct: 1876 CHTGFKTNEDQTMCLDINECERDA---CGNGTCRNTIGSFNCRCNHGFILSHNND-CI 1929
Score = 47.8 bits (112), Expect = 9e-05
Identities = 43/166 (25%), Positives = 61/166 (35%), Gaps = 49/166 (29%)
Query: 417 VETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKG---DGYTTCEAS--- 470
++ NEC + C + C++T CEC + G + CE +
Sbjct: 2523 IDNNECTSDINLC-----GSKGICQNTPGSFTCECQRGFSLDQSGASCEDVDECEGNHRC 2577
Query: 471 --------GPGRCKIKNGGCWHEARNGHAFSACVDD------------------GEVKCQ 504
G RC G H + ++ CVD+ G KC
Sbjct: 2578 QHGCQNIIGGYRCSCPQGYLQH-----YQWNQCVDENECLSAHVCGGASCHNTLGSYKCM 2632
Query: 505 CPAGFKGDGVKN-CQDVDECKEKKACQCPECS--CKNTWGSYDCSC 547
CPAGF+ + CQD++EC +A CS C NT G Y C C
Sbjct: 2633 CPAGFQYEQFSGGCQDINECGSSQA----PCSYGCSNTEGGYLCGC 2674
Score = 47.4 bits (111), Expect = 1e-04
Identities = 96/427 (22%), Positives = 138/427 (31%), Gaps = 92/427 (21%)
Query: 171 SGGEMVNVNLDWREAVPHPDD---------RVEYELWTNSN---DECGVKCDMLMEFVKD 218
SG M + D E PD R Y+ NS D G C + E V +
Sbjct: 713 SGPGMTSAGTDINECALDPDICPNGICENLRGTYKCICNSGYEVDITGKNCVDINECVLN 772
Query: 219 FKGAAQILEKGGYTQFTPHYITWYCPKAFTLSKQCK----------SQCINH------GR 262
+L G + TP CPK F K S CIN G
Sbjct: 773 -----SLLCDNGQCRNTPGSFVCTCPKGFVYKPDLKTCEDIDECESSPCINGVCKNSPGS 827
Query: 263 Y-CAPDPEQDFSTGYDGKDVVIENLRQLCVYKVTSEAKKPWLWWDYVTDFQIRCPMKEKK 321
+ C PE ST K + IE ++ C W V D + +
Sbjct: 828 FICECSPE---STLDPTKTICIETIKGTC--------------WQTVIDGRCEININGAT 870
Query: 322 YNKKCADAVIESLGLDNKKIERCMGDPDADSDNPVLKEEQDAQVGKGSRGDVTILPTLVV 381
+C ++ + G C DP +K Q + + L V
Sbjct: 871 LKSECCSSLGAAWG---SPCTICQLDPICGKGFSRIKGTQCEDINECEVFPGVCKNGLCV 927
Query: 382 NNRQYRGKLEKGAVMKAICSGFEETTEPAVCLSSDVET-------NECLENNGGCWKDKA 434
N+R G+ +G +CL +ET EC G + A
Sbjct: 928 NSR--------GSFKCECPNGMTLDATGRICLDIRLETCFLKYDDEECTLPIAGRHRMDA 979
Query: 435 ANITACKDTFRGRVCECPLVDGVQF-----KGDGYTTCEASGP-------GRCKIKNGGC 482
+ ECPL + ++ +G G+ T + + CK+ C
Sbjct: 980 CCCSVGAAWGTEECEECPLRNSREYEELCPRGPGFATKDITNGKPFFKDINECKMIPSLC 1039
Query: 483 WH-EARNGHAFSACVDDGEVKCQCPAGFKGDGV-KNCQDVDECKEKKACQCPECSCKNTW 540
H + RN G KC+C +GF D +NC D+DEC+ C C NT
Sbjct: 1040 THGKCRN--------TIGSFKCRCDSGFALDSEERNCTDIDECRISPDL-CGRGQCVNTP 1090
Query: 541 GSYDCSC 547
G ++C C
Sbjct: 1091 GDFECKC 1097
Score = 47.4 bits (111), Expect = 1e-04
Identities = 24/63 (38%), Positives = 34/63 (53%), Gaps = 2/63 (3%)
Query: 499 GEVKCQCPAGFKGDGV-KNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDH 557
G KC C +G++ D KNC D++EC + C C+NT GS+ C+C +Y D
Sbjct: 744 GTYKCICNSGYEVDITGKNCVDINECV-LNSLLCDNGQCRNTPGSFVCTCPKGFVYKPDL 802
Query: 558 DTC 560
TC
Sbjct: 803 KTC 805
Score = 46.2 bits (108), Expect = 3e-04
Identities = 23/77 (29%), Positives = 38/77 (48%), Gaps = 3/77 (3%)
Query: 499 GEVKCQCPAGFK-GDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDH 557
G +C+CP G+ + + C DV+EC+ C +C NT G+Y C C D + +
Sbjct: 1627 GSFQCRCPTGYYLNEDTRVCDDVNECETPGICG--PGTCYNTVGNYTCICPPDYMQVNGG 1684
Query: 558 DTCISKTASQGGRSAWA 574
+ C+ S R+ +A
Sbjct: 1685 NNCMDMRRSICYRNYYA 1701
Score = 45.8 bits (107), Expect = 3e-04
Identities = 24/70 (34%), Positives = 34/70 (48%), Gaps = 8/70 (11%)
Query: 498 DGEVKCQCPAGFK-GDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSC------SGD 550
+G +C+CP G + + C D++EC E A CP C N G Y C+C + D
Sbjct: 1133 EGTYRCECPPGHQLSPNISACIDINEC-ELSANLCPHGRCVNLIGKYQCACNPGYHPTHD 1191
Query: 551 LLYIRDHDTC 560
L+ D D C
Sbjct: 1192 RLFCVDIDEC 1201
Score = 45.4 bits (106), Expect = 4e-04
Identities = 22/63 (34%), Positives = 27/63 (41%)
Query: 499 GEVKCQCPAGFKGDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDHD 558
G C+C GF +C DVDEC C C NT GS+ C C+ D
Sbjct: 1910 GSFNCRCNHGFILSHNNDCIDVDECATGNGNLCRNGQCVNTVGSFQCRCNEGYEVAPDGR 1969
Query: 559 TCI 561
TC+
Sbjct: 1970 TCV 1972
Score = 45.1 bits (105), Expect = 6e-04
Identities = 23/64 (35%), Positives = 30/64 (45%), Gaps = 2/64 (3%)
Query: 499 GEVKCQCPAGFKGDGV-KNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDH 557
G +C+CPAG K + V + C+D+DEC C C NT SY C C D
Sbjct: 267 GSFECKCPAGHKFNEVSQKCEDIDECSTIPGV-CDGGECTNTVSSYFCKCPPGFYTSPDG 325
Query: 558 DTCI 561
C+
Sbjct: 326 TRCV 329
Score = 45.1 bits (105), Expect = 6e-04
Identities = 33/123 (26%), Positives = 49/123 (39%), Gaps = 21/123 (17%)
Query: 440 CKDTFRGRVCECPLVDGVQFKGDGYTTCEASGPGRCKIKNGGCWHEARNGHAFSACVDDG 499
C +T CECP G +G+ E C + N NG + G
Sbjct: 2142 CINTDGSYRCECPF--GYILEGN-----ECVDTDECSVGN-----PCGNGTCKNVI---G 2186
Query: 500 EVKCQCPAGFKGDGVKNCQDVDECKEKKACQCPECS--CKNTWGSYDCSCSGDLLYIRDH 557
+C C GF+ + C+D++EC + C+ C NT+GSY+C C + D
Sbjct: 2187 GFECTCEEGFEPGPMMTCEDINECAQNPLL----CAFRCVNTYGSYECKCPVGYVLREDR 2242
Query: 558 DTC 560
C
Sbjct: 2243 RMC 2245
Score = 44.7 bits (104), Expect = 8e-04
Identities = 46/175 (26%), Positives = 66/175 (37%), Gaps = 34/175 (19%)
Query: 397 KAICSGFE----ETTEPAVCLSSDVETNECLENNGGCWKDKAANITACKDTFRGRVCECP 452
K + GFE E EP ++ + + NEC +N C C +T+ C+CP
Sbjct: 2182 KNVIGGFECTCEEGFEPGPMMTCE-DINECAQNPLLC-------AFRCVNTYGSYECKCP 2233
Query: 453 LVDGVQFKGDGYTTCE----ASGPGRCKIKNGGCWHEARNGHAFSACVDDGEVKCQCPAG 508
+ G + D + A G C K C + G C C G
Sbjct: 2234 V--GYVLREDRRMCKDEDECAEGKHDCTEKQMECKNLI------------GTYMCICGPG 2279
Query: 509 F--KGDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDHDTCI 561
+ + DG + C D +EC+ K C C NT GSY C C+ D C+
Sbjct: 2280 YQRRPDG-EGCIDENECQTKPGI-CENGRCLNTLGSYTCECNDGFTASPTQDECL 2332
Score = 44.7 bits (104), Expect = 8e-04
Identities = 23/52 (44%), Positives = 29/52 (55%), Gaps = 6/52 (11%)
Query: 499 GEVKCQCPAGF--KGDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSCS 548
G C CP GF K D +K C+D+DEC+ C CKN+ GS+ C CS
Sbjct: 786 GSFVCTCPKGFVYKPD-LKTCEDIDECESSP---CINGVCKNSPGSFICECS 833
Score = 43.9 bits (102), Expect = 0.001
Identities = 23/49 (46%), Positives = 26/49 (52%), Gaps = 3/49 (6%)
Query: 499 GEVKCQCPAGFKGDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSC 547
G +C+C GF+ D C DVDEC EK C EC N GSY C C
Sbjct: 470 GSYRCECNKGFQLDIRGECIDVDEC-EKNPCTGGECI--NNQGSYTCHC 515
Score = 43.9 bits (102), Expect = 0.001
Identities = 21/56 (37%), Positives = 32/56 (56%), Gaps = 4/56 (7%)
Query: 495 CVDD-GEVKCQCPAGFKGDGV--KNCQDVDECKEKKACQCPECSCKNTWGSYDCSC 547
CV+ G+ +C+C G++ + KNC D+DEC ++ C C NT G+Y C C
Sbjct: 1086 CVNTPGDFECKCDEGYESGFMMMKNCMDIDEC-QRDPLLCRGGICHNTEGTYRCEC 1140
Score = 43.9 bits (102), Expect = 0.001
Identities = 49/178 (27%), Positives = 66/178 (36%), Gaps = 33/178 (18%)
Query: 400 CSGFEETTEPAVCLSSDVETNECLENNGG----CWKDKAANIT--ACKDTFRGRVCECPL 453
C+ E +P C+S + C+ G C D N T C DT G C L
Sbjct: 1485 CTDVNECLDPTTCISGN-----CVNTPGSYTCDCSPDFELNPTRVGCVDTRSGN---CYL 1536
Query: 454 VDGVQFKGD-GYTTCEAS-----GPGRCKIKNGGCWHEARNGHAFSAC--VDDGEVKCQC 505
++ +GD G T C C G W G C V+ E K C
Sbjct: 1537 --NIRPRGDNGDTACSNEIGVGVSKASCCCSLGKAW-----GTPCELCPSVNTSEYKILC 1589
Query: 506 PAG--FKGDGVKNC-QDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDHDTC 560
P G F+ + + +D+DEC+E C C NT+GS+ C C D C
Sbjct: 1590 PGGEGFRPNPITVILEDIDECQELPGL-CQGGKCINTFGSFQCRCPTGYYLNEDTRVC 1646
Score = 42.4 bits (98), Expect = 0.004
Identities = 51/172 (29%), Positives = 72/172 (41%), Gaps = 29/172 (16%)
Query: 399 ICSGFE--ETTEPAVCLS-SDVETNE----CLENNGGCWKDKAANITACKDTFRGRVCEC 451
ICS + +T CL + +TNE CL+ N C +D N T C++T C C
Sbjct: 1859 ICSHGQCIDTVGSFYCLCHTGFKTNEDQTMCLDINE-CERDACGNGT-CRNTIGSFNCRC 1916
Query: 452 PLVDGVQFKGDGYTTCEASGPGRCKIKNGGCWHEARNGHAFSACVDD-GEVKCQCPAGFK 510
+ D E C NG RNG CV+ G +C+C G++
Sbjct: 1917 NHGFILSHNNDCIDVDE------CATGNGNL---CRNGQ----CVNTVGSFQCRCNEGYE 1963
Query: 511 --GDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDHDTC 560
DG + C D++EC +C +C+N GSY C C Y +D C
Sbjct: 1964 VAPDG-RTCVDINECVLDPG-KCAPGTCQNLDGSYRCICPPG--YSLQNDKC 2011
Score = 40.0 bits (92), Expect = 0.019
Identities = 41/128 (32%), Positives = 47/128 (36%), Gaps = 10/128 (7%)
Query: 422 CLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGYTTCEASGPGRCKIKNGG 481
CL N G C A N AC F G CE G F C+ G K
Sbjct: 154 CL-NGGRC---VAPNRCACTYGFTGPQCERDYRTGPCFTVVSNQMCQGQLSGIVCTKTLC 209
Query: 482 CWHEARN-GHAFSACVDDGEVKCQCPAGFKGD-GVKNCQDVDECKEKKACQCPECSCKNT 539
C R GH C C GF + CQDVDEC+ C +C NT
Sbjct: 210 CATVGRAWGHPCEMCPAQPH---PCRRGFIPNIRTGACQDVDECQAIPG-MCQGGNCINT 265
Query: 540 WGSYDCSC 547
GS++C C
Sbjct: 266 VGSFECKC 273
Score = 38.5 bits (88), Expect = 0.054
Identities = 34/123 (27%), Positives = 50/123 (40%), Gaps = 17/123 (13%)
Query: 440 CKDTFRGRVCECPLVDGVQFKGDGYTTCEASGPGRCKIKNGGCWHEARNGHAFSACVD-D 498
C +T CECP G Q + + + C++ C H CV+
Sbjct: 1129 CHNTEGTYRCECP--PGHQLSPNISACIDIN---ECELSANLCPH--------GRCVNLI 1175
Query: 499 GEVKCQCPAGFKGDGVKN-CQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDH 557
G+ +C C G+ + C D+DEC C E C N+ GSY+CSC + D
Sbjct: 1176 GKYQCACNPGYHPTHDRLFCVDIDECSIMNG-GC-ETFCTNSDGSYECSCQPGFALMPDQ 1233
Query: 558 DTC 560
+C
Sbjct: 1234 RSC 1236
Score = 37.7 bits (86), Expect = 0.092
Identities = 45/177 (25%), Positives = 67/177 (37%), Gaps = 37/177 (20%)
Query: 409 PAVCLSSDV--ETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGYTT 466
P L +D + +EC+E C + C +T C CP +G + G
Sbjct: 2002 PGYSLQNDKCEDIDECVEEPEIC------ALGTCSNTEGSFKCLCP--EGFSWSSSG-RR 2052
Query: 467 CEASGPGRC--KIKNGGCWHEARNGHAFSACV-----DDGEVKCQ-CPA----GFK---- 510
C+ C K + G C H+ C + C+ CP F+
Sbjct: 2053 CQDLRMSYCYAKFEGGKCSSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQICP 2112
Query: 511 -GDGV-----KNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDHDTCI 561
G G+ + D+DECKE C+ +C NT GSY C C YI + + C+
Sbjct: 2113 FGSGIIVGPDDSAVDMDECKEPDVCRHGQCI--NTDGSYRCEC--PFGYILEGNECV 2165
>FBN1_HUMAN (P35555) Fibrillin 1 precursor
Length = 2871
Score = 62.8 bits (151), Expect = 3e-09
Identities = 59/201 (29%), Positives = 76/201 (37%), Gaps = 41/201 (20%)
Query: 397 KAIC-SGFEETTEPAVCLSSDVETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVD 455
+ +C GF + + C V+ NEC N C C++T +C C +
Sbjct: 1262 RCLCYDGFMASEDMKTC----VDVNECDLNPNICLSG------TCENTKGSFICHCDM-- 1309
Query: 456 GVQFKGDGYTTCEASGPGRCKIKNGGCWHEARNGHAFSACVDD-GEVKCQCPAGFKGDGV 514
G K G T C + C+I C A C + G KC C G+ GDG+
Sbjct: 1310 GYSGK-KGKTGC--TDINECEIGAHNCGKHA-------VCTNTAGSFKCSCSPGWIGDGI 1359
Query: 515 KNCQDVDECKEKKACQCPECSCKNTWGSYDCSC----SGDLLYIRDHDTCISKTASQGGR 570
K C D+DEC CKNT GSY C C +GD D D C G
Sbjct: 1360 K-CTDLDECSNGTHMCSQHADCKNTMGSYRCLCKEGYTGDGFTCTDLDECSENLNLCGN- 1417
Query: 571 SAWAAFWVIIAGLVLSAGGGY 591
G L+A GGY
Sbjct: 1418 -----------GQCLNAPGGY 1427
Score = 53.5 bits (127), Expect = 2e-06
Identities = 53/167 (31%), Positives = 70/167 (41%), Gaps = 38/167 (22%)
Query: 420 NECLENNGG-CWKDKAANIT--------------ACKDTFRG--RVCE-CPLVDGVQFK- 460
+ECL+N G C+ + N+ C D RG CE CP V FK
Sbjct: 2329 DECLDNREGYCFTEVLQNMCQIGSSNRNPVTKSECCCDGGRGWGPHCEICPFQGTVAFKK 2388
Query: 461 ----GDGYTTCEASGPGRCKIKNGGCWHEARNGHAFSACVDD-GEVKCQCPAGFKGDGV- 514
G G+ T + CK+ + C RNG CV+D G C C G+ D
Sbjct: 2389 LCPHGRGFMT-NGADIDECKVIHDVC----RNGE----CVNDRGSYHCICKTGYTPDITG 2439
Query: 515 KNCQDVDECKEK-KACQCPECSCKNTWGSYDCSCSGDLLYIRDHDTC 560
+C D++EC + K C CKNT GSY CSC + D +C
Sbjct: 2440 TSCVDLNECNQAPKPCNF---ICKNTEGSYQCSCPKGYILQEDGRSC 2483
Score = 53.1 bits (126), Expect = 2e-06
Identities = 37/131 (28%), Positives = 55/131 (41%), Gaps = 19/131 (14%)
Query: 417 VETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGYTTCEASGPGRCK 476
++ +EC NG ++ C +T C+C +GY E + GR
Sbjct: 1929 IDVDECASGNGNLCRNGQ-----CINTVGSFQCQC---------NEGY---EVAPDGRTC 1971
Query: 477 IKNGGCWHEARNGHAFSACVDDGEVKCQCPAGFKGDGVKNCQDVDECKEKKACQCPECSC 536
+ C E R + DG +C CP G+ K C+D+DEC E+ C +C
Sbjct: 1972 VDINECLLEPRKCAPGTCQNLDGSYRCICPPGYSLQNEK-CEDIDECVEEPEI-CALGTC 2029
Query: 537 KNTWGSYDCSC 547
NT GS+ C C
Sbjct: 2030 SNTEGSFKCLC 2040
Score = 50.8 bits (120), Expect = 1e-05
Identities = 37/126 (29%), Positives = 51/126 (40%), Gaps = 19/126 (15%)
Query: 440 CKDTFRGRVCECPLVDGVQFKGDGYTTCEASGPGRCKIKNGGCWHEARNGHAFSACVDD- 498
C +T G C+CP G+T S C I N C + + C +
Sbjct: 2500 CVNTIGGFTCKCP---------PGFTQHHTS----C-IDNNECTSDINLCGSKGICQNTP 2545
Query: 499 GEVKCQCPAGFKGDGV-KNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDH 557
G C+C GF D +C+DVDEC+ CQ C+N G Y CSC L
Sbjct: 2546 GSFTCECQRGFSLDQTGSSCEDVDECEGNHRCQH---GCQNIIGGYRCSCPQGYLQHYQW 2602
Query: 558 DTCISK 563
+ C+ +
Sbjct: 2603 NQCVDE 2608
Score = 50.8 bits (120), Expect = 1e-05
Identities = 49/163 (30%), Positives = 64/163 (39%), Gaps = 28/163 (17%)
Query: 401 SGFEETTEPAVCLSSDVETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFK 460
+G++ T C D ECL+N C N C +T C C G
Sbjct: 517 AGYQSTLTRTECRDID----ECLQNGRIC------NNGRCINTDGSFHCVCNA--GFHVT 564
Query: 461 GDGYTTCEASGPGRCKIKNGGCWHEARNGHAFSACVDDGEVKCQCPAGFK--GDGVKNCQ 518
DG CE C I+N NG + +DG KC C GF+ DG + C+
Sbjct: 565 RDG-KNCEDMD--ECSIRN-----MCLNGMCIN---EDGSFKCICKPGFQLASDG-RYCK 612
Query: 519 DVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDHDTCI 561
D++EC+ C C NT GSY C C L D C+
Sbjct: 613 DINECETPGICM--NGRCVNTDGSYRCECFPGLAVGLDGRVCV 653
Score = 50.4 bits (119), Expect = 1e-05
Identities = 43/156 (27%), Positives = 64/156 (40%), Gaps = 29/156 (18%)
Query: 420 NECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGYTTCE-----ASGPGR 474
NEC++ + + N T CK+ G C C +G F+ TCE A P
Sbjct: 2162 NECVDTDECSVGNPCGNGT-CKNVIGGFECTCE--EG--FEPGPMMTCEDINECAQNPLL 2216
Query: 475 CKIKNGGCWHEARNGHAFSACVDD-GEVKCQCPAGFK-GDGVKNCQDVDECKE-KKACQC 531
C + CV+ G +C+CP G+ + + C+D DEC+E K C
Sbjct: 2217 CAFR----------------CVNTYGSYECKCPVGYVLREDRRMCKDEDECEEGKHDCTE 2260
Query: 532 PECSCKNTWGSYDCSCSGDLLYIRDHDTCISKTASQ 567
+ CKN G+Y C C D + C+ + Q
Sbjct: 2261 KQMECKNLIGTYMCICGPGYQRRPDGEGCVDENECQ 2296
Score = 49.3 bits (116), Expect = 3e-05
Identities = 49/178 (27%), Positives = 68/178 (37%), Gaps = 46/178 (25%)
Query: 417 VETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGYTTCE-------- 468
V+ +EC E G C N+ +FR CECP+ F D CE
Sbjct: 1765 VDIDECREIPGVCENGVCINMVG---SFR---CECPVGF---FYNDKLLVCEDIDECQNG 1815
Query: 469 -----------ASGPGRCKIK-------NGGC-----WHEARNGHAFSACVDD-GEVKCQ 504
+G RC K G C E N + C+D G C
Sbjct: 1816 PVCQRNAECINTAGSYRCDCKPGYRFTSTGQCNDRNECQEIPNICSHGQCIDTVGSFYCL 1875
Query: 505 CPAGFK-GDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDHDTCI 561
C GFK D C D++EC+ C +C+NT GS++C C+ + ++D CI
Sbjct: 1876 CHTGFKTNDDQTMCLDINECERDA---CGNGTCRNTIGSFNCRCNHGFILSHNND-CI 1929
Score = 49.3 bits (116), Expect = 3e-05
Identities = 24/63 (38%), Positives = 34/63 (53%), Gaps = 2/63 (3%)
Query: 499 GEVKCQCPAGFKGDGV-KNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDH 557
G KC C +G++ D KNC D++EC + C C+NT GS+ C+C +Y D
Sbjct: 744 GTYKCICNSGYEVDSTGKNCVDINECV-LNSLLCDNGQCRNTPGSFVCTCPKGFIYKPDL 802
Query: 558 DTC 560
TC
Sbjct: 803 KTC 805
Score = 48.9 bits (115), Expect = 4e-05
Identities = 42/143 (29%), Positives = 52/143 (35%), Gaps = 29/143 (20%)
Query: 436 NITACKDTFRGRVCE-----CPLVDGVQFKGDGYTTCEA---SGPGR--------CKIKN 479
NI+AC D CE CP V G C S P R C I N
Sbjct: 1149 NISACIDI---NECELSAHLCPNGRCVNLIGKYQCACNPGYHSTPDRLFCVDIDECSIMN 1205
Query: 480 GGCWHEARNGHAFSACVDDGEVKCQCPAGFK-GDGVKNCQDVDECKEKKACQCPECSCKN 538
GGC N +G +C C GF ++C D+DEC++ C C N
Sbjct: 1206 GGCETFCTNS--------EGSYECSCQPGFALMPDQRSCTDIDECEDNPNI-CDGGQCTN 1256
Query: 539 TWGSYDCSCSGDLLYIRDHDTCI 561
G Y C C + D TC+
Sbjct: 1257 IPGEYRCLCYDGFMASEDMKTCV 1279
Score = 48.1 bits (113), Expect = 7e-05
Identities = 44/169 (26%), Positives = 63/169 (37%), Gaps = 49/169 (28%)
Query: 414 SSDVETNECLENNGGCWKDKAANITACKDTFRGRVCECPL---VDGVQFKGDGYTTCEAS 470
+S ++ NEC + C + C++T CEC +D + CE +
Sbjct: 2520 TSCIDNNECTSDINLC-----GSKGICQNTPGSFTCECQRGFSLDQTGSSCEDVDECEGN 2574
Query: 471 -----------GPGRCKIKNGGCWHEARNGHAFSACVDD------------------GEV 501
G RC G H + ++ CVD+ G
Sbjct: 2575 HRCQHGCQNIIGGYRCSCPQGYLQH-----YQWNQCVDENECLSAHICGGASCHNTLGSY 2629
Query: 502 KCQCPAGFKGDGVKN-CQDVDECKEKKACQCPECS--CKNTWGSYDCSC 547
KC CPAGF+ + CQD++EC +A CS C NT G Y C C
Sbjct: 2630 KCMCPAGFQYEQFSGGCQDINECGSAQA----PCSYGCSNTEGGYLCGC 2674
Score = 47.4 bits (111), Expect = 1e-04
Identities = 95/426 (22%), Positives = 134/426 (31%), Gaps = 90/426 (21%)
Query: 171 SGGEMVNVNLDWREAVPHPDD---------RVEYELWTNSN---DECGVKCDMLMEFVKD 218
SG M + D E PD R Y+ NS D G C + E V +
Sbjct: 713 SGPGMTSAGSDINECALDPDICPNGICENLRGTYKCICNSGYEVDSTGKNCVDINECVLN 772
Query: 219 FKGAAQILEKGGYTQFTPHYITWYCPKAFTLSKQCK----------SQCINHGRYCAPDP 268
+L G + TP CPK F K S CIN C P
Sbjct: 773 -----SLLCDNGQCRNTPGSFVCTCPKGFIYKPDLKTCEDIDECESSPCING--VCKNSP 825
Query: 269 EQDF------STGYDGKDVVIENLRQLCVYKVTSEAKKPWLWWDYVTDFQIRCPMKEKKY 322
ST K + IE ++ C W V D + +
Sbjct: 826 GSFICECSSESTLDPTKTICIETIKGTC--------------WQTVIDGRCEININGATL 871
Query: 323 NKKCADAVIESLGLDNKKIERCMGDPDADSDNPVLKEEQDAQVGKGSRGDVTILPTLVVN 382
+C ++ + G C DP +K Q + + L VN
Sbjct: 872 KSQCCSSLGAAWG---SPCTLCQVDPICGKGYSRIKGTQCEDIDECEVFPGVCKNGLCVN 928
Query: 383 NRQYRGKLEKGAVMKAICSGFEETTEPAVCLSSDVET-------NECLENNGGCWKDKAA 435
R G+ SG +CL +ET EC G + A
Sbjct: 929 TR--------GSFKCQCPSGMTLDATGRICLDIRLETCFLRYEDEECTLPIAGRHRMDAC 980
Query: 436 NITACKDTFRGRVCECPLVDGVQF-----KGDGYTTCEASGP-------GRCKIKNGGCW 483
+ ECP+ + ++ +G G+ T E + CK+ C
Sbjct: 981 CCSVGAAWGTEECEECPMRNTPEYEELCPRGPGFATKEITNGKPFFKDINECKMIPSLCT 1040
Query: 484 H-EARNGHAFSACVDDGEVKCQCPAGFKGDGV-KNCQDVDECKEKKACQCPECSCKNTWG 541
H + RN G KC+C +GF D +NC D+DEC+ C C NT G
Sbjct: 1041 HGKCRN--------TIGSFKCRCDSGFALDSEERNCTDIDECRISPDL-CGRGQCVNTPG 1091
Query: 542 SYDCSC 547
++C C
Sbjct: 1092 DFECKC 1097
Score = 47.4 bits (111), Expect = 1e-04
Identities = 35/135 (25%), Positives = 52/135 (37%), Gaps = 25/135 (18%)
Query: 440 CKDTFRGRVCECPLVDGVQFKGDGYTTC--EASGPGRCKIKNGGCWHEARNGHAFSACVD 497
C +T CECP GYT E C + N NG +
Sbjct: 2142 CINTDGSYRCECPF---------GYTLAGNECVDTDECSVGN-----PCGNGTCKNVI-- 2185
Query: 498 DGEVKCQCPAGFKGDGVKNCQDVDECKEKKACQCPECS--CKNTWGSYDCSCSGDLLYIR 555
G +C C GF+ + C+D++EC + C+ C NT+GSY+C C +
Sbjct: 2186 -GGFECTCEEGFEPGPMMTCEDINECAQNPLL----CAFRCVNTYGSYECKCPVGYVLRE 2240
Query: 556 DHDTCISKTASQGGR 570
D C + + G+
Sbjct: 2241 DRRMCKDEDECEEGK 2255
Score = 47.0 bits (110), Expect = 2e-04
Identities = 37/141 (26%), Positives = 60/141 (42%), Gaps = 22/141 (15%)
Query: 446 GRVCE-CPLVDGVQFK-----GDGYT----TCEASGPGRCKIKNGGCWHEARNGHAFSAC 495
G CE CP V+ ++K G+G+ T C+ G C C
Sbjct: 1571 GTPCEMCPAVNTSEYKILCPGGEGFRPNPITVILEDIDECQELPGLCQG--------GKC 1622
Query: 496 VDD-GEVKCQCPAGFK-GDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLY 553
++ G +C+CP G+ + + C DV+EC+ C +C NT G+Y C C D +
Sbjct: 1623 INTFGSFQCRCPTGYYLNEDTRVCDDVNECETPGICG--PGTCYNTVGNYTCICPPDYMQ 1680
Query: 554 IRDHDTCISKTASQGGRSAWA 574
+ + C+ S R+ +A
Sbjct: 1681 VNGGNNCMDMRRSLCYRNYYA 1701
Score = 46.2 bits (108), Expect = 3e-04
Identities = 25/76 (32%), Positives = 37/76 (47%), Gaps = 3/76 (3%)
Query: 487 RNGHAFSACVDD-GEVKCQCPAGFKGDGVKN-CQDVDECKEKKACQCPECSCKNTWGSYD 544
+N A C+++ G CQC AG++ + C+D+DEC + C C NT GS+
Sbjct: 496 KNPCAGGECINNQGSYTCQCRAGYQSTLTRTECRDIDECLQNGRI-CNNGRCINTDGSFH 554
Query: 545 CSCSGDLLYIRDHDTC 560
C C+ RD C
Sbjct: 555 CVCNAGFHVTRDGKNC 570
Score = 45.8 bits (107), Expect = 3e-04
Identities = 22/63 (34%), Positives = 27/63 (41%)
Query: 499 GEVKCQCPAGFKGDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDHD 558
G C+C GF +C DVDEC C C NT GS+ C C+ D
Sbjct: 1910 GSFNCRCNHGFILSHNNDCIDVDECASGNGNLCRNGQCINTVGSFQCQCNEGYEVAPDGR 1969
Query: 559 TCI 561
TC+
Sbjct: 1970 TCV 1972
Score = 45.4 bits (106), Expect = 4e-04
Identities = 23/54 (42%), Positives = 30/54 (54%), Gaps = 6/54 (11%)
Query: 499 GEVKCQCPAGF--KGDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGD 550
G C CP GF K D +K C+D+DEC+ C CKN+ GS+ C CS +
Sbjct: 786 GSFVCTCPKGFIYKPD-LKTCEDIDECESSP---CINGVCKNSPGSFICECSSE 835
Score = 45.1 bits (105), Expect = 6e-04
Identities = 30/85 (35%), Positives = 40/85 (46%), Gaps = 12/85 (14%)
Query: 495 CVD-DGEVKCQCPAGFK--GDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSC---- 547
C++ DG C C AGF DG KNC+D+DEC + C C N GS+ C C
Sbjct: 546 CINTDGSFHCVCNAGFHVTRDG-KNCEDMDECSIRN--MCLNGMCINEDGSFKCICKPGF 602
Query: 548 --SGDLLYIRDHDTCISKTASQGGR 570
+ D Y +D + C + GR
Sbjct: 603 QLASDGRYCKDINECETPGICMNGR 627
Score = 45.1 bits (105), Expect = 6e-04
Identities = 47/176 (26%), Positives = 67/176 (37%), Gaps = 36/176 (20%)
Query: 397 KAICSGFE----ETTEPAVCLSSDVETNECLENNGGCWKDKAANITACKDTFRGRVCECP 452
K + GFE E EP ++ + + NEC +N C C +T+ C+CP
Sbjct: 2182 KNVIGGFECTCEEGFEPGPMMTCE-DINECAQNPLLC-------AFRCVNTYGSYECKCP 2233
Query: 453 LVDGVQFKGD-----GYTTCEASGPGRCKIKNGGCWHEARNGHAFSACVDDGEVKCQCPA 507
+ G + D CE G C K C + G C C
Sbjct: 2234 V--GYVLREDRRMCKDEDECE-EGKHDCTEKQMECKNLI------------GTYMCICGP 2278
Query: 508 GF--KGDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDHDTCI 561
G+ + DG + C D +EC+ K C C NT GSY C C+ + D C+
Sbjct: 2279 GYQRRPDG-EGCVDENECQTKPGI-CENGRCLNTRGSYTCECNDGFTASPNQDECL 2332
Score = 45.1 bits (105), Expect = 6e-04
Identities = 24/64 (37%), Positives = 30/64 (46%), Gaps = 2/64 (3%)
Query: 499 GEVKCQCPAGFKGDGV-KNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDH 557
G +C+CPAG K + V + C+D+DEC C C NT SY C C D
Sbjct: 267 GSFECKCPAGHKLNEVSQKCEDIDECSTIPGI-CEGGECTNTVSSYFCKCPPGFYTSPDG 325
Query: 558 DTCI 561
CI
Sbjct: 326 TRCI 329
Score = 45.1 bits (105), Expect = 6e-04
Identities = 22/56 (39%), Positives = 32/56 (56%), Gaps = 4/56 (7%)
Query: 495 CVDD-GEVKCQCPAGFKGDGV--KNCQDVDECKEKKACQCPECSCKNTWGSYDCSC 547
CV+ G+ +C+C G++ + KNC D+DEC ++ C C NT GSY C C
Sbjct: 1086 CVNTPGDFECKCDEGYESGFMMMKNCMDIDEC-QRDPLLCRGGVCHNTEGSYRCEC 1140
Score = 44.7 bits (104), Expect = 8e-04
Identities = 42/143 (29%), Positives = 55/143 (38%), Gaps = 38/143 (26%)
Query: 440 CKDTFRGRVCECPLVDGVQFKGDGYTTCEAS---------GPGRCKIKNGGCWHEARNGH 490
CK+T C C +G + GDG+T + G G+C GG E G
Sbjct: 1380 CKNTMGSYRCLCK--EG--YTGDGFTCTDLDECSENLNLCGNGQCLNAPGGYRCECDMGF 1435
Query: 491 AFSA----CVD------------------DGEVKCQCPAGFKGD-GVKNCQDVDECKEKK 527
SA C D G +C+C G++ D NC DV+EC +
Sbjct: 1436 VPSADGKACEDIDECSLPNICVFGTCHNLPGLFRCECEIGYELDRSGGNCTDVNECLDPT 1495
Query: 528 ACQCPECSCKNTWGSYDCSCSGD 550
C +C NT GSY C C D
Sbjct: 1496 TCISG--NCVNTPGSYICDCPPD 1516
Score = 44.3 bits (103), Expect = 0.001
Identities = 23/49 (46%), Positives = 26/49 (52%), Gaps = 3/49 (6%)
Query: 499 GEVKCQCPAGFKGDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSC 547
G +C+C GF+ D C DVDEC EK C EC N GSY C C
Sbjct: 470 GSYRCECNKGFQLDLRGECIDVDEC-EKNPCAGGECI--NNQGSYTCQC 515
Score = 43.1 bits (100), Expect = 0.002
Identities = 41/149 (27%), Positives = 61/149 (40%), Gaps = 28/149 (18%)
Query: 401 SGFEETTEPAVCLSSDVETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFK 460
+GF+ + +CL + NEC +D N T C++T C C +
Sbjct: 1878 TGFKTNDDQTMCL----DINECE-------RDACGNGT-CRNTIGSFNCRCNHGFILSHN 1925
Query: 461 GDGYTTCEASGPGRCKIKNGGCWHEARNGHAFSACVDDGEVKCQCPAGFK--GDGVKNCQ 518
D E C NG RNG + G +CQC G++ DG + C
Sbjct: 1926 NDCIDVDE------CASGNGNL---CRNGQCINTV---GSFQCQCNEGYEVAPDG-RTCV 1972
Query: 519 DVDECKEKKACQCPECSCKNTWGSYDCSC 547
D++EC + +C +C+N GSY C C
Sbjct: 1973 DINECLLEPR-KCAPGTCQNLDGSYRCIC 2000
Score = 39.7 bits (91), Expect = 0.024
Identities = 41/128 (32%), Positives = 47/128 (36%), Gaps = 10/128 (7%)
Query: 422 CLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGYTTCEASGPGRCKIKNGG 481
CL N G C A N AC F G CE G F C+ G K
Sbjct: 154 CL-NGGRC---VAPNRCACTYGFTGPQCERDYRTGPCFTVISNQMCQGQLSGIVCTKQLC 209
Query: 482 CWHEARN-GHAFSACVDDGEVKCQCPAGFKGD-GVKNCQDVDECKEKKACQCPECSCKNT 539
C R GH C C GF + CQDVDEC+ C +C NT
Sbjct: 210 CATVGRAWGHPCEMCPAQPH---PCRRGFIPNIRTGACQDVDECQAIPGL-CQGGNCINT 265
Query: 540 WGSYDCSC 547
GS++C C
Sbjct: 266 VGSFECKC 273
Score = 38.9 bits (89), Expect = 0.041
Identities = 33/122 (27%), Positives = 49/122 (40%), Gaps = 15/122 (12%)
Query: 440 CKDTFRGRVCECPLVDGVQFKGDGYTTCEASGPGRCKIKNGGCWHEARNGHAFSACVDDG 499
C +T CECP G Q + + + C++ H NG + G
Sbjct: 1129 CHNTEGSYRCECP--PGHQLSPNISACIDIN---ECELSA----HLCPNGRCVNLI---G 1176
Query: 500 EVKCQCPAGFKGDGVKN-CQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDHD 558
+ +C C G+ + C D+DEC C E C N+ GSY+CSC + D
Sbjct: 1177 KYQCACNPGYHSTPDRLFCVDIDECSIMNG-GC-ETFCTNSEGSYECSCQPGFALMPDQR 1234
Query: 559 TC 560
+C
Sbjct: 1235 SC 1236
Score = 35.8 bits (81), Expect = 0.35
Identities = 39/152 (25%), Positives = 56/152 (36%), Gaps = 33/152 (21%)
Query: 418 ETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGYTTCEASGPGRC-- 475
+ +EC+E C + C +T C CP +G G C+ C
Sbjct: 2013 DIDECVEEPEIC------ALGTCSNTEGSFKCLCP--EGFSLSSSG-RRCQDLRMSYCYA 2063
Query: 476 KIKNGGCWHEARNGHAFSACV-----DDGEVKCQ-CPA----GFK-----GDGV-----K 515
K + G C H+ C + C+ CP F+ G G+
Sbjct: 2064 KFEGGKCSSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQICPYGSGIIVGPDD 2123
Query: 516 NCQDVDECKEKKACQCPECSCKNTWGSYDCSC 547
+ D+DECKE C+ +C NT GSY C C
Sbjct: 2124 SAVDMDECKEPDVCKHGQCI--NTDGSYRCEC 2153
>GAS6_HUMAN (Q14393) Growth-arrest-specific protein 6 precursor
(GAS-6)
Length = 721
Score = 62.4 bits (150), Expect = 3e-09
Identities = 41/123 (33%), Positives = 52/123 (41%), Gaps = 27/123 (21%)
Query: 461 GDGYTTCEASGPGR--------CKIKNGGCWHEARNGHAFSACVDDGEVKCQCPAGFK-- 510
G+ + C+A GR C +NGGC N G C C +GF+
Sbjct: 138 GNFFCLCKAGWGGRLCDKDVNECSQENGGCLQICHN--------KPGSFHCSCHSGFELS 189
Query: 511 GDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLY------IRDHDTCISKT 564
DG + CQD+DEC + +AC E CKN GSY C C Y RD D C+
Sbjct: 190 SDG-RTCQDIDECADSEACG--EARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQGR 246
Query: 565 ASQ 567
Q
Sbjct: 247 CEQ 249
Score = 55.5 bits (132), Expect = 4e-07
Identities = 47/156 (30%), Positives = 57/156 (36%), Gaps = 43/156 (27%)
Query: 416 DVETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGYT--------TC 467
D + NEC + NGGC + C + C C G + DG T
Sbjct: 154 DKDVNECSQENGGC-------LQICHNKPGSFHCSCH--SGFELSSDGRTCQDIDECADS 204
Query: 468 EASGPGRCKIKNGGCWHEARNGHAFSACVDDGEVKCQCPAGFK-GDGVKNCQDVDECKEK 526
EA G RCK G C C GF K C+DVDEC +
Sbjct: 205 EACGEARCKNL-------------------PGSYSCLCDEGFAYSSQEKACRDVDECLQG 245
Query: 527 KACQCPECSCKNTWGSYDCSCS--GDLLYIRDHDTC 560
+ E C N+ GSY C C G L +D DTC
Sbjct: 246 RC----EQVCVNSPGSYTCHCDGRGGLKLSQDMDTC 277
>FBN1_BOVIN (P98133) Fibrillin 1 precursor (MP340)
Length = 2871
Score = 62.4 bits (150), Expect = 3e-09
Identities = 59/201 (29%), Positives = 76/201 (37%), Gaps = 41/201 (20%)
Query: 397 KAIC-SGFEETTEPAVCLSSDVETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVD 455
+ +C GF + + C V+ NEC N C C++T +C C +
Sbjct: 1262 RCLCYDGFMASEDMKTC----VDVNECDLNPNICLSG------TCENTKGSFICHCDM-- 1309
Query: 456 GVQFKGDGYTTCEASGPGRCKIKNGGCWHEARNGHAFSACVDD-GEVKCQCPAGFKGDGV 514
G K G T C + C+I C A C + G KC C G+ GDG+
Sbjct: 1310 GYSGK-KGKTGC--TDINECEIGAHNCDRHA-------VCTNTAGSFKCSCSPGWIGDGI 1359
Query: 515 KNCQDVDECKEKKACQCPECSCKNTWGSYDCSC----SGDLLYIRDHDTCISKTASQGGR 570
K C D+DEC CKNT GSY C C +GD D D C G
Sbjct: 1360 K-CTDLDECSNGTHMCSQHADCKNTMGSYRCLCKEGYTGDGFTCTDLDECSENLNLCGN- 1417
Query: 571 SAWAAFWVIIAGLVLSAGGGY 591
G L+A GGY
Sbjct: 1418 -----------GQCLNAPGGY 1427
Score = 52.8 bits (125), Expect = 3e-06
Identities = 53/167 (31%), Positives = 69/167 (40%), Gaps = 38/167 (22%)
Query: 420 NECLENNGG-CWKDKAANIT--------------ACKDTFRG--RVCE-CPLVDGVQFK- 460
+ECL+N G C+ + N+ C D RG CE CP V FK
Sbjct: 2329 DECLDNREGYCFTEVLQNMCQIGSSNRNPVTKSECCCDGGRGWGPHCEICPFQGTVAFKK 2388
Query: 461 ----GDGYTTCEASGPGRCKIKNGGCWHEARNGHAFSACVDD-GEVKCQCPAGFKGDGVK 515
G G+ T + CK+ + C RNG CV+D G C C G+ D
Sbjct: 2389 LCPHGRGFMT-NGADIDECKVIHDVC----RNGE----CVNDRGSYHCICKTGYTPDITG 2439
Query: 516 N-CQDVDECKEK-KACQCPECSCKNTWGSYDCSCSGDLLYIRDHDTC 560
C D++EC + K C CKNT GSY CSC + D +C
Sbjct: 2440 TACVDLNECNQAPKPCNF---ICKNTEGSYQCSCPKGYILQEDGRSC 2483
Score = 52.0 bits (123), Expect = 5e-06
Identities = 44/159 (27%), Positives = 67/159 (41%), Gaps = 29/159 (18%)
Query: 417 VETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGYTTCE-----ASG 471
++ NEC++ + + N T CK+ G C C +G F+ TCE A
Sbjct: 2159 LQGNECVDTDECSVGNPCGNGT-CKNVIGGFECTCE--EG--FEPGPMMTCEDINECAQN 2213
Query: 472 PGRCKIKNGGCWHEARNGHAFSACVDD-GEVKCQCPAGFK-GDGVKNCQDVDECKE-KKA 528
P C + CV+ G +C+CPAG+ + + C+D DEC+E K
Sbjct: 2214 PLLCAFR----------------CVNTYGSYECKCPAGYVLREDRRMCKDEDECEEGKHD 2257
Query: 529 CQCPECSCKNTWGSYDCSCSGDLLYIRDHDTCISKTASQ 567
C + CKN G+Y C C D + C+ + Q
Sbjct: 2258 CAEKQMECKNLIGTYLCICGPGYQRRPDGEGCVDENECQ 2296
Score = 51.2 bits (121), Expect = 8e-06
Identities = 53/195 (27%), Positives = 67/195 (34%), Gaps = 41/195 (21%)
Query: 391 EKGAVMKAICSGFEETT-EPAVCLSSDVETNECLENNGGC------WKDKAANITACKDT 443
E G +M C +E +P +C CL G A NI+AC D
Sbjct: 1102 ESGFMMMKNCMDIDECQRDPLLCRGG-----VCLNTEGSYRCECPPGHQLAPNISACIDI 1156
Query: 444 FRGRVCE-----CPLVDGVQFKGDGYTTCEA---SGPGR--------CKIKNGGCWHEAR 487
CE CP V G C S P R C I NGGC
Sbjct: 1157 ---NECELSAHLCPHGRCVNLIGKYQCACNPGYHSTPDRLFCVDIDECSIMNGGCETFCT 1213
Query: 488 NGHAFSACVDDGEVKCQCPAGFK-GDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCS 546
N +G +C C GF ++C D+DEC++ C C N G Y C
Sbjct: 1214 NS--------EGSYECSCQPGFALMPDQRSCTDIDECEDNPNI-CDGGQCTNIPGEYRCL 1264
Query: 547 CSGDLLYIRDHDTCI 561
C + D TC+
Sbjct: 1265 CYDGFMASEDMKTCV 1279
Score = 50.1 bits (118), Expect = 2e-05
Identities = 49/162 (30%), Positives = 63/162 (38%), Gaps = 28/162 (17%)
Query: 402 GFEETTEPAVCLSSDVETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKG 461
G++ T C D ECL+N C N C +T C C G
Sbjct: 518 GYQSTLTRTECRDID----ECLQNGRIC------NNGRCINTDGSFHCVCNA--GFHVTR 565
Query: 462 DGYTTCEASGPGRCKIKNGGCWHEARNGHAFSACVDDGEVKCQCPAGFK--GDGVKNCQD 519
DG CE C I+N NG + +DG KC C GF+ DG + C+D
Sbjct: 566 DG-KNCEDMD--ECSIRN-----MCLNGMCIN---EDGSFKCICKPGFQLASDG-RYCKD 613
Query: 520 VDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDHDTCI 561
++EC+ C C NT GSY C C L D C+
Sbjct: 614 INECETLGICM--NGRCVNTDGSYRCECFPGLAVGLDGRVCV 653
Score = 48.5 bits (114), Expect = 5e-05
Identities = 73/316 (23%), Positives = 105/316 (33%), Gaps = 79/316 (25%)
Query: 314 RCPMKEKKYNKKCADAVIESLG----LDNKK------IERCMGDPDADSDNPVLKEEQDA 363
RC Y +C D S LDN++ + + M + + NPV K E
Sbjct: 2306 RCLNTRGSYTCECNDGFTASPNQDECLDNREGYCFTEVLQNMCQIGSSNRNPVTKSECCC 2365
Query: 364 QVGKGSRGDVTILP---TLVVNNR--QYRGKLEKGA------VMKAICSGFEETTEPA-- 410
G+G I P T+ RG + GA V+ +C E +
Sbjct: 2366 DGGRGWGPHCEICPFQGTVAFKKLCPHGRGFMTNGADIDECKVIHDVCRNGECVNDRGSY 2425
Query: 411 --VCLSS---DVETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDG-- 463
+C + D+ C++ N K N CK+T C CP G + DG
Sbjct: 2426 HCICKTGYTPDITGTACVDLNECNQAPKPCNFI-CKNTEGSYQCSCP--KGYILQEDGRS 2482
Query: 464 ---------------YTTCEASGPGRCKIKNGGCWHEARNGHAFSACVDD---------- 498
+ G CK G H +AC+D+
Sbjct: 2483 CKDLDECATKQHNCQFLCVNTIGSFTCKCPPGFTQHH-------TACIDNNECTSDINLC 2535
Query: 499 ----------GEVKCQCPAGFKGDGV-KNCQDVDECKEKKACQCPECSCKNTWGSYDCSC 547
G C+C GF D +C+DVDEC+ CQ C+N G Y CSC
Sbjct: 2536 GSKGICQNTPGSFTCECQRGFSLDPTGASCEDVDECEGNHRCQH---GCQNIIGGYRCSC 2592
Query: 548 SGDLLYIRDHDTCISK 563
L + C+ +
Sbjct: 2593 PQGYLQHYQWNQCVDE 2608
Score = 48.1 bits (113), Expect = 7e-05
Identities = 48/178 (26%), Positives = 69/178 (37%), Gaps = 46/178 (25%)
Query: 417 VETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGYTTCE-------- 468
V+ +EC E G C N+ +FR CECP+ F D CE
Sbjct: 1765 VDIDECREIPGVCENGVCINMVG---SFR---CECPVGF---FYNDKLLVCEDIDECQNG 1815
Query: 469 -----------ASGPGRCKIK-------NGGC-----WHEARNGHAFSACVDD-GEVKCQ 504
+G RC K G C E N + C+D G C
Sbjct: 1816 PVCQRNAECINTAGSYRCDCKPGYRFTSTGQCNDRNECQEIPNICSHGQCIDTVGSFYCL 1875
Query: 505 CPAGFKGDGVKN-CQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDHDTCI 561
C GFK + + C D++EC+ C +C+NT GS++C C+ + ++D CI
Sbjct: 1876 CHTGFKTNADQTMCLDINECERDA---CGNGTCRNTIGSFNCRCNHGFILSHNND-CI 1929
Score = 47.8 bits (112), Expect = 9e-05
Identities = 43/166 (25%), Positives = 62/166 (36%), Gaps = 49/166 (29%)
Query: 417 VETNECLENNGGCWKDKAANITACKDTFRGRVCECPL---VDGVQFKGDGYTTCEAS--- 470
++ NEC + C + C++T CEC +D + CE +
Sbjct: 2523 IDNNECTSDINLC-----GSKGICQNTPGSFTCECQRGFSLDPTGASCEDVDECEGNHRC 2577
Query: 471 --------GPGRCKIKNGGCWHEARNGHAFSACVDD------------------GEVKCQ 504
G RC G H + ++ CVD+ G KC
Sbjct: 2578 QHGCQNIIGGYRCSCPQGYLQH-----YQWNQCVDENECLSAHICGGASCHNTLGSYKCM 2632
Query: 505 CPAGFKGDGVKN-CQDVDECKEKKACQCPECS--CKNTWGSYDCSC 547
CPAGF+ + CQD++EC +A CS C NT G Y C+C
Sbjct: 2633 CPAGFQYEQFSGGCQDINECGSAQA----PCSYGCSNTEGGYLCAC 2674
Score = 47.8 bits (112), Expect = 9e-05
Identities = 23/63 (36%), Positives = 34/63 (53%), Gaps = 2/63 (3%)
Query: 499 GEVKCQCPAGFKGDGV-KNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDH 557
G KC C +G++ D KNC D++EC + C C+NT GS+ C+C +Y +
Sbjct: 744 GTYKCICNSGYEVDSTGKNCVDINECV-LNSLLCDNGQCRNTPGSFVCTCPKGFIYKPEL 802
Query: 558 DTC 560
TC
Sbjct: 803 KTC 805
Score = 47.8 bits (112), Expect = 9e-05
Identities = 34/112 (30%), Positives = 50/112 (44%), Gaps = 23/112 (20%)
Query: 450 ECPLVDGVQF-----KGDGYTTCEASGPGR-------CKIKNGGCWH-EARNGHAFSACV 496
ECP+ + ++ +G G+ T E + R CK+ C H + RN
Sbjct: 995 ECPVRNTPEYEELCPRGPGFATKEITNGKRFFKDINECKMIPNLCTHGKCRN-------- 1046
Query: 497 DDGEVKCQCPAGFKGDGV-KNCQDVDECKEKKACQCPECSCKNTWGSYDCSC 547
G KC+C +GF D +NC D+DEC+ C C NT G ++C C
Sbjct: 1047 TIGSFKCRCDSGFALDSEERNCTDIDECRISPDL-CGRGQCVNTPGDFECKC 1097
Score = 47.4 bits (111), Expect = 1e-04
Identities = 34/133 (25%), Positives = 53/133 (39%), Gaps = 21/133 (15%)
Query: 440 CKDTFRGRVCECPLVDGVQFKGDGYTTCEASGPGRCKIKNGGCWHEARNGHAFSACVDDG 499
C +T CECP G +G+ E C + N NG + G
Sbjct: 2142 CINTDGSYRCECPF--GYILQGN-----ECVDTDECSVGN-----PCGNGTCKNVI---G 2186
Query: 500 EVKCQCPAGFKGDGVKNCQDVDECKEKKACQCPECS--CKNTWGSYDCSCSGDLLYIRDH 557
+C C GF+ + C+D++EC + C+ C NT+GSY+C C + D
Sbjct: 2187 GFECTCEEGFEPGPMMTCEDINECAQNPLL----CAFRCVNTYGSYECKCPAGYVLREDR 2242
Query: 558 DTCISKTASQGGR 570
C + + G+
Sbjct: 2243 RMCKDEDECEEGK 2255
Score = 46.6 bits (109), Expect = 2e-04
Identities = 23/77 (29%), Positives = 38/77 (48%), Gaps = 3/77 (3%)
Query: 499 GEVKCQCPAGFK-GDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDH 557
G +C+CP G+ + + C DV+EC+ C +C NT G+Y C C D + +
Sbjct: 1627 GSFQCRCPTGYYLNEDTRVCDDVNECETPGICG--PGTCYNTVGNYTCICPPDYMQVNGG 1684
Query: 558 DTCISKTASQGGRSAWA 574
+ C+ S R+ +A
Sbjct: 1685 NNCMDMRRSLCYRNYYA 1701
Score = 46.2 bits (108), Expect = 3e-04
Identities = 24/49 (48%), Positives = 27/49 (54%), Gaps = 3/49 (6%)
Query: 499 GEVKCQCPAGFKGDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSC 547
G +C+C GF+ D C DVDEC EK C EC NT GSY C C
Sbjct: 470 GSYRCECNKGFQLDLRGECIDVDEC-EKNPCAGGECI--NTQGSYTCQC 515
Score = 45.8 bits (107), Expect = 3e-04
Identities = 86/396 (21%), Positives = 132/396 (32%), Gaps = 83/396 (20%)
Query: 203 DECGVKCDMLMEFVKDFKGAAQILEKGGYTQFTPHYITWYCPKAFTLSKQCKSQCIN-HG 261
DEC ++ L + G+ + + K G+ + + TL +C+N G
Sbjct: 574 DECSIRNMCLNGMCINEDGSFKCICKPGFQLASDGRYCKDINECETLGICMNGRCVNTDG 633
Query: 262 RY---CAPDPEQDFSTGYDGKDVVIENLRQLCV--YKVTSEAKKPWLWWDYVTDFQIRCP 316
Y C P + G DG+ V ++R C YK + KP + VT + C
Sbjct: 634 SYRCECFPG----LAVGLDGRVCVDTHMRSTCYGGYK-RGQCVKPL--FGAVTKSECCCA 686
Query: 317 MKEKKYNKKCADAVIESLGLDNKKIERCMGDPDADSDNPVLKEEQDAQVGKGSRGDVTIL 376
E + + C ++ + C P S + E D I
Sbjct: 687 STEYAFGEPCQPCPSQNSA---EYQALCSSGPGITSAGSDINE---------CALDPDIC 734
Query: 377 PTLVVNNRQYRGKLEKGAVMKAIC-SGFEETTEPAVCLSSDVETNECLEN-----NGGCW 430
P + N + K IC SG+E + C V+ NEC+ N NG C
Sbjct: 735 PNGICENLR--------GTYKCICNSGYEVDSTGKNC----VDINECVLNSLLCDNGQCR 782
Query: 431 KDKAANITACKDTF----RGRVCE-------CPLVDGVQFKGDGYTTCEASGP------- 472
+ + C F + CE P ++GV G CE S
Sbjct: 783 NTPGSFVCTCPKGFIYKPELKTCEDIDECESSPCINGVCKNSPGSFICECSSESTLDPTK 842
Query: 473 -----------------GRCKIKNGGCWHEARNGHAFSACVDDGEVKCQ----CPAGFKG 511
GRC+I G +++ + A CQ C G+
Sbjct: 843 TICIETIKGTCWQTVIDGRCEININGATLKSQCCSSLGAAWGSPCTPCQVDPICGKGYSR 902
Query: 512 DGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSC 547
C+D+DEC+ C C N+ GS+ C C
Sbjct: 903 IKGTQCEDIDECEVFPGV-CKNGLCVNSKGSFKCQC 937
Score = 45.4 bits (106), Expect = 4e-04
Identities = 42/143 (29%), Positives = 55/143 (38%), Gaps = 38/143 (26%)
Query: 440 CKDTFRGRVCECPLVDGVQFKGDGYTTCEAS---------GPGRCKIKNGGCWHEARNGH 490
CK+T C C +G + GDG+T + G G+C GG E G
Sbjct: 1380 CKNTMGSYRCLCK--EG--YTGDGFTCTDLDECSENLNLCGNGQCLNAPGGYRCECDMGF 1435
Query: 491 AFSA----CVD------------------DGEVKCQCPAGFKGD-GVKNCQDVDECKEKK 527
SA C D G +C+C G++ D NC DV+EC +
Sbjct: 1436 VPSADGKACEDIDECSLPNICVFGTCHNLPGLFRCECEIGYELDRSGGNCTDVNECLDPT 1495
Query: 528 ACQCPECSCKNTWGSYDCSCSGD 550
C +C NT GSY C C D
Sbjct: 1496 TCISG--NCVNTPGSYTCDCPPD 1516
Score = 45.4 bits (106), Expect = 4e-04
Identities = 24/64 (37%), Positives = 30/64 (46%), Gaps = 2/64 (3%)
Query: 499 GEVKCQCPAGFKGDGV-KNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDH 557
G +C+CPAG K + V + C+D+DEC C C NT SY C C D
Sbjct: 267 GSFECKCPAGHKFNEVSQKCEDIDECSTIPGI-CDGGECTNTVSSYFCKCPPGFYTSPDG 325
Query: 558 DTCI 561
CI
Sbjct: 326 TRCI 329
Score = 45.4 bits (106), Expect = 4e-04
Identities = 22/63 (34%), Positives = 27/63 (41%)
Query: 499 GEVKCQCPAGFKGDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDHD 558
G C+C GF +C DVDEC C C NT GS+ C C+ D
Sbjct: 1910 GSFNCRCNHGFILSHNNDCIDVDECATGNGNLCRNGQCINTVGSFQCQCNEGYEVAPDGR 1969
Query: 559 TCI 561
TC+
Sbjct: 1970 TCV 1972
Score = 45.1 bits (105), Expect = 6e-04
Identities = 47/159 (29%), Positives = 66/159 (40%), Gaps = 27/159 (16%)
Query: 421 ECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGYTTCEASGPGRCKIKNG 480
EC++ + C K+ A C +T C+C G Q T E C ++NG
Sbjct: 487 ECIDVDE-CEKNPCAG-GECINTQGSYTCQCR--PGYQ---STLTRTECRDIDEC-LQNG 538
Query: 481 GCWHEARNGHAFSACVD-DGEVKCQCPAGFK--GDGVKNCQDVDECKEKKACQCPECSCK 537
+ R C++ DG C C AGF DG KNC+D+DEC + C C
Sbjct: 539 RICNNGR-------CINTDGSFHCVCNAGFHVTRDG-KNCEDMDECSIRN--MCLNGMCI 588
Query: 538 NTWGSYDCSC------SGDLLYIRDHDTCISKTASQGGR 570
N GS+ C C + D Y +D + C + GR
Sbjct: 589 NEDGSFKCICKPGFQLASDGRYCKDINECETLGICMNGR 627
Score = 44.3 bits (103), Expect = 0.001
Identities = 21/53 (39%), Positives = 28/53 (52%), Gaps = 4/53 (7%)
Query: 499 GEVKCQCPAGF-KGDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGD 550
G C CP GF +K C+D+DEC+ C CKN+ GS+ C CS +
Sbjct: 786 GSFVCTCPKGFIYKPELKTCEDIDECESSP---CINGVCKNSPGSFICECSSE 835
Score = 43.9 bits (102), Expect = 0.001
Identities = 47/176 (26%), Positives = 66/176 (36%), Gaps = 36/176 (20%)
Query: 397 KAICSGFE----ETTEPAVCLSSDVETNECLENNGGCWKDKAANITACKDTFRGRVCECP 452
K + GFE E EP ++ + + NEC +N C C +T+ C+CP
Sbjct: 2182 KNVIGGFECTCEEGFEPGPMMTCE-DINECAQNPLLC-------AFRCVNTYGSYECKCP 2233
Query: 453 LVDGVQFKGD-----GYTTCEASGPGRCKIKNGGCWHEARNGHAFSACVDDGEVKCQCPA 507
G + D CE G C K C + G C C
Sbjct: 2234 A--GYVLREDRRMCKDEDECE-EGKHDCAEKQMECKNLI------------GTYLCICGP 2278
Query: 508 GF--KGDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDHDTCI 561
G+ + DG + C D +EC+ K C C NT GSY C C+ + D C+
Sbjct: 2279 GYQRRPDG-EGCVDENECQTKPGI-CENGRCLNTRGSYTCECNDGFTASPNQDECL 2332
Score = 43.5 bits (101), Expect = 0.002
Identities = 44/162 (27%), Positives = 64/162 (39%), Gaps = 30/162 (18%)
Query: 401 SGFEETTEPAVCLSSDVETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFK 460
+GF+ + +CL + NEC +D N T C++T C C +
Sbjct: 1878 TGFKTNADQTMCL----DINECE-------RDACGNGT-CRNTIGSFNCRCNHGFILSHN 1925
Query: 461 GDGYTTCEASGPGRCKIKNGGCWHEARNGHAFSACVDDGEVKCQCPAGFK--GDGVKNCQ 518
D E C NG RNG + G +CQC G++ DG + C
Sbjct: 1926 NDCIDVDE------CATGNGNL---CRNGQCINTV---GSFQCQCNEGYEVAPDG-RTCV 1972
Query: 519 DVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDHDTC 560
D++EC +C +C+N GSY C C Y +D C
Sbjct: 1973 DINECLLDPR-KCAPGTCQNLDGSYRCICPPG--YSLQNDKC 2011
Score = 43.1 bits (100), Expect = 0.002
Identities = 49/178 (27%), Positives = 66/178 (36%), Gaps = 33/178 (18%)
Query: 400 CSGFEETTEPAVCLSSDVETNECLENNGG----CWKDKAANIT--ACKDTFRGRVCECPL 453
C+ E +P C+S + C+ G C D N T C DT G C L
Sbjct: 1485 CTDVNECLDPTTCISGN-----CVNTPGSYTCDCPPDFELNPTRVGCVDTRSGN---CYL 1536
Query: 454 VDGVQFKGD-GYTTCEAS-----GPGRCKIKNGGCWHEARNGHAFSAC--VDDGEVKCQC 505
++ +GD G T C C G W G C V+ E K C
Sbjct: 1537 --DIRPRGDNGDTACSNEIGVGVSKASCCCSLGKAW-----GTPCELCPPVNTSEYKILC 1589
Query: 506 PAG--FKGDGVKNC-QDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDHDTC 560
P G F+ + + +D+DEC+E C C NT+GS+ C C D C
Sbjct: 1590 PGGEGFRPNPITVILEDIDECQELPGL-CQGGKCINTFGSFQCRCPTGYYLNEDTRVC 1646
Score = 39.7 bits (91), Expect = 0.024
Identities = 41/128 (32%), Positives = 47/128 (36%), Gaps = 10/128 (7%)
Query: 422 CLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGYTTCEASGPGRCKIKNGG 481
CL N G C A N AC F G CE G F C+ G K
Sbjct: 154 CL-NGGRC---VAPNRCACTYGFTGPQCERDYRTGPCFTVISNQMCQGQLSGIVCTKTLC 209
Query: 482 CWHEARN-GHAFSACVDDGEVKCQCPAGFKGD-GVKNCQDVDECKEKKACQCPECSCKNT 539
C R GH C C GF + CQDVDEC+ C +C NT
Sbjct: 210 CATVGRAWGHPCEMCPAQPH---PCRRGFIPNIRTGACQDVDECQAIPGL-CQGGNCINT 265
Query: 540 WGSYDCSC 547
GS++C C
Sbjct: 266 VGSFECKC 273
Score = 37.7 bits (86), Expect = 0.092
Identities = 46/177 (25%), Positives = 65/177 (35%), Gaps = 37/177 (20%)
Query: 409 PAVCLSSDV--ETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGYTT 466
P L +D + +EC+E C + C +T C CP DG G
Sbjct: 2002 PGYSLQNDKCEDIDECVEEPEIC------ALGTCSNTEGSFKCLCP--DGFSLSSTG-RR 2052
Query: 467 CEASGPGRC--KIKNGGCWHEARNGHAFSACV-----DDGEVKCQ-CPA----GFK---- 510
C+ C K + G C H+ C + C+ CP F+
Sbjct: 2053 CQDLRMSYCYAKFEGGKCSSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQICP 2112
Query: 511 -GDGV-----KNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDHDTCI 561
G G+ + D+DECKE C+ +C NT GSY C C YI + C+
Sbjct: 2113 YGSGIIVGPDDSAVDMDECKEPDVCKHGQCI--NTDGSYRCEC--PFGYILQGNECV 2165
Score = 32.7 bits (73), Expect = 3.0
Identities = 42/159 (26%), Positives = 57/159 (35%), Gaps = 45/159 (28%)
Query: 422 CLEN-NGGCWK---DKAANITACKDTFRGRVCE---------CPLVDGVQFKGDGY---- 464
C+E G CW+ D I T + + C C G GY
Sbjct: 845 CIETIKGTCWQTVIDGRCEININGATLKSQCCSSLGAAWGSPCTPCQVDPICGKGYSRIK 904
Query: 465 -TTCEASGPGRCKIKNGGCWHEARNGHAFSACVDD-GEVKCQCPAGFKGDGV-KNCQDV- 520
T CE C++ G C +NG CV+ G KCQCP+G D + C D+
Sbjct: 905 GTQCEDID--ECEVFPGVC----KNG----LCVNSKGSFKCQCPSGMTLDATGRICLDIR 954
Query: 521 -DEC---KEKKACQCPE----------CSCKNTWGSYDC 545
+ C E + C P CS WG+ +C
Sbjct: 955 LETCFLRYEDEECTLPVAGRHRMDACCCSVGAAWGTEEC 993
>GAS6_RAT (Q63772) Growth-arrest-specific protein 6 precursor
(GAS-6) (Growth-potentiating factor) (GPF)
Length = 674
Score = 60.8 bits (146), Expect = 1e-08
Identities = 57/195 (29%), Positives = 75/195 (38%), Gaps = 37/195 (18%)
Query: 387 RGKLEKGAVMKAICSGFEETTEPAVCLSSDVETN-------ECLENNGGCWKDKAANITA 439
+G LE+ V + +CS EE E +D ET+ EC+ G +DK N
Sbjct: 55 QGHLERECV-EEVCSK-EEARE---VFENDPETDYFYPRYQECMRKYGRP-EDKNPNFAT 108
Query: 440 CKDTFRGRVCECPL-VDGVQF----KGDGYTTCEASGPGR--------CKIKNGGCWHEA 486
C + P G Q G+ + C+ GR C KNGGC
Sbjct: 109 CVKNLPDQCTPNPCDKKGTQLCQDLMGNFFCLCKDGWGGRLCDKDVNECSQKNGGCSQVC 168
Query: 487 RNGHAFSACVDDGEVKCQCPAGFK-GDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDC 545
N G +C C +GF K+CQD+DEC + C + CKN GSY C
Sbjct: 169 HN--------KPGSFQCACHSGFSLQSDNKSCQDIDECTDSDTCG--DARCKNLPGSYSC 218
Query: 546 SCSGDLLYIRDHDTC 560
C Y TC
Sbjct: 219 LCDKGYTYSSKEKTC 233
Score = 53.1 bits (126), Expect = 2e-06
Identities = 44/154 (28%), Positives = 57/154 (36%), Gaps = 39/154 (25%)
Query: 416 DVETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKG------DGYTTCEA 469
D + NEC + NGGC + C + C C +Q D T +
Sbjct: 151 DKDVNECSQKNGGCSQ-------VCHNKPGSFQCACHSGFSLQSDNKSCQDIDECTDSDT 203
Query: 470 SGPGRCKIKNGGCWHEARNGHAFSACVDDGEVKCQCPAGFK-GDGVKNCQDVDECKEKKA 528
G RCK G C C G+ K CQDVDEC++ +
Sbjct: 204 CGDARCKNL-------------------PGSYSCLCDKGYTYSSKEKTCQDVDECQQDRC 244
Query: 529 CQCPECSCKNTWGSYDCSCS--GDLLYIRDHDTC 560
E +C N+ GSY C C+ G L D DTC
Sbjct: 245 ----EQTCVNSPGSYTCHCNGRGGLKLSPDMDTC 274
>UROM_RAT (P27590) Uromodulin precursor (Tamm-Horsfall urinary
glycoprotein) (THP)
Length = 644
Score = 60.5 bits (145), Expect = 1e-08
Identities = 29/59 (49%), Positives = 34/59 (57%), Gaps = 2/59 (3%)
Query: 490 HAFSACVDDGEVK-CQCPAGFKGDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSC 547
H + CV DG V C C AGF GDG+ C+D+DEC C C NT GSY+CSC
Sbjct: 38 HDNATCVLDGVVTTCSCQAGFTGDGLV-CEDIDECATPWTHNCSNSICMNTLGSYECSC 95
Score = 44.7 bits (104), Expect = 8e-04
Identities = 35/133 (26%), Positives = 46/133 (34%), Gaps = 27/133 (20%)
Query: 418 ETNECLE--NNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGYTTCEASGPGRC 475
E C E +N C D +C+ F G C +D E + P
Sbjct: 30 EARRCSECHDNATCVLDGVVTTCSCQAGFTGDGLVCEDID------------ECATPWTH 77
Query: 476 KIKNGGCWHEARNGHAFSACVDDGEVKCQCPAGFKGDGVKNCQDVDECKEKKACQCPE-C 534
N C + G +C C GF+ C DV+EC E+ C
Sbjct: 78 NCSNSICMNTL------------GSYECSCQDGFRLTPGLGCIDVNECTEQGLSNCHSLA 125
Query: 535 SCKNTWGSYDCSC 547
+C NT GSY C C
Sbjct: 126 TCVNTEGSYSCVC 138
Score = 34.7 bits (78), Expect = 0.78
Identities = 24/86 (27%), Positives = 35/86 (39%), Gaps = 16/86 (18%)
Query: 430 WKDKAANITACKDTFRGRVCECPLVDGVQFKGDGYTTCEASGPGRCKIKNGGCWHEA-RN 488
W +N + C +T C C DG+ PG I C + N
Sbjct: 75 WTHNCSN-SICMNTLGSYECSCQ---------DGFRLT----PGLGCIDVNECTEQGLSN 120
Query: 489 GHAFSACVD-DGEVKCQCPAGFKGDG 513
H+ + CV+ +G C CP G++GDG
Sbjct: 121 CHSLATCVNTEGSYSCVCPKGYRGDG 146
>FBN3_HUMAN (Q75N90) Fibrillin 3 precursor
Length = 2809
Score = 60.5 bits (145), Expect = 1e-08
Identities = 51/170 (30%), Positives = 74/170 (43%), Gaps = 29/170 (17%)
Query: 397 KAIC-SGFEETTEPAVCLSSDVETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVD 455
+ +C GF T + C V+ +EC N C C++T VC C L
Sbjct: 1220 RCLCYDGFMATPDMRTC----VDVDECDLNPHICLHGD------CENTKGSFVCHCQLGY 1269
Query: 456 GVQFKGDGYTTCEASGPGRCKIKNGGCWHEARNGHAFSACVD-DGEVKCQCPAGFKGDGV 514
V+ G T C S C++ C + HA +C++ G C+C G+ GDG
Sbjct: 1270 MVR---KGATGC--SDVDECEVGGHNC-----DSHA--SCLNIPGSFSCRCLPGWVGDGF 1317
Query: 515 KNCQDVDECKEKKACQCPECSCKNTWGSYDCSC----SGDLLYIRDHDTC 560
+ C D+DEC ++ P C N GSY C+C +GD + D D C
Sbjct: 1318 E-CHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDEC 1366
Score = 53.9 bits (128), Expect = 1e-06
Identities = 54/199 (27%), Positives = 78/199 (39%), Gaps = 49/199 (24%)
Query: 391 EKGAVMKAICSGFEETT-EPAVCLSSDVETNECLENNGGCWK-------DKAANITACKD 442
E G ++ C +E +P +C N G +K + A TAC+D
Sbjct: 1060 ESGFMLMKNCMDVDECARDPLLCRGGTCT------NTDGSYKCQCPPGHELTAKGTACED 1113
Query: 443 TFRGRVCECPLVDG-------VQFKGDGYTTCEA---SGPGR--------CKIKNGGCWH 484
+ EC L DG V G +C A S P R C+++NGGC
Sbjct: 1114 -----IDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGC-- 1166
Query: 485 EARNGHAFSACVDDGEVKCQCPAGFK--GDGVKNCQDVDECKEKKACQCPECSCKNTWGS 542
+ H + +G +C C G+ DG + C DVDEC+E C + C N G
Sbjct: 1167 ---DVHCINT---EGSYRCSCGQGYSLMPDG-RACADVDECEENPRV-CDQGHCTNMPGG 1218
Query: 543 YDCSCSGDLLYIRDHDTCI 561
+ C C + D TC+
Sbjct: 1219 HRCLCYDGFMATPDMRTCV 1237
Score = 52.8 bits (125), Expect = 3e-06
Identities = 46/166 (27%), Positives = 62/166 (36%), Gaps = 36/166 (21%)
Query: 402 GFEETTEPAVCLSSDVETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKG 461
GF+ T C V+ +EC+ + G C ++ C +T C C G +
Sbjct: 477 GFQATPTRQAC----VDVDECIVSGGLC------HLGRCVNTEGSFQCVCNA--GFELSP 524
Query: 462 DG-----YTTCEASGPGRCKIKNGGCWHEARNGHAFSACVDDGEVKCQCPAGFK-GDGVK 515
DG + C S NG C +E DG C C GF G
Sbjct: 525 DGKNCVDHNECATS----TMCVNGVCLNE------------DGSFSCLCKPGFLLAPGGH 568
Query: 516 NCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDHDTCI 561
C D+DEC+ C C+ NT GS+ C C G L D C+
Sbjct: 569 YCMDIDECQTPGICVNGHCT--NTEGSFRCQCLGGLAVGTDGRVCV 612
Score = 51.2 bits (121), Expect = 8e-06
Identities = 43/151 (28%), Positives = 55/151 (35%), Gaps = 31/151 (20%)
Query: 418 ETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGYTTCEASGPGRCKI 477
+ NEC EN G C N +FR CECP + F G + G
Sbjct: 2084 DVNECAENPGVCTNGVCVNTDG---SFR---CECPFGYSLDFTGINCVDTDECSVG---- 2133
Query: 478 KNGGCWHEARNGHAFSACVDDGEVKCQCPAGFKGDGVKNCQDVDECKEKKACQCPECS-- 535
H G + G +C C GF+ + C+D+DEC C+
Sbjct: 2134 ------HPCGQGTCTNVI---GGFECACADGFEPGLMMTCEDIDECSLNPLL----CAFR 2180
Query: 536 CKNTWGSYDCSCSG------DLLYIRDHDTC 560
C NT GSY C+C D RD D C
Sbjct: 2181 CHNTEGSYLCTCPAGYTLREDGAMCRDVDEC 2211
Score = 51.2 bits (121), Expect = 8e-06
Identities = 41/124 (33%), Positives = 52/124 (41%), Gaps = 21/124 (16%)
Query: 446 GRVCE-CPLVDGVQFK-----GDGYTTCEASGPGRCKIKNGGCWHEARNGHAFSACVDD- 498
G CE CPL ++ G GYT E C++ C H C++
Sbjct: 2333 GPRCELCPLPGTSAYRKLCPHGSGYTA-EGRDVDECRMLAHLCAH--------GECINSL 2383
Query: 499 GEVKCQCPAGFKGDGVKN-CQDVDECKE-KKACQCPECSCKNTWGSYDCSCSGDLLYIRD 556
G +C C AG+ D C D+DEC + K C CKNT GS+ CSC L D
Sbjct: 2384 GSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTF---LCKNTKGSFLCSCPRGYLLEED 2440
Query: 557 HDTC 560
TC
Sbjct: 2441 GRTC 2444
Score = 50.1 bits (118), Expect = 2e-05
Identities = 23/74 (31%), Positives = 38/74 (51%), Gaps = 3/74 (4%)
Query: 495 CVDD-GEVKCQCPAGFK-GDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLL 552
CV+ G +C+CP G+ + + C+D+DEC + C +C NT G+Y C C + L
Sbjct: 1579 CVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSSI-CGPGTCYNTLGNYTCVCPAEYL 1637
Query: 553 YIRDHDTCISKTAS 566
+ + C+ S
Sbjct: 1638 QVNGGNNCMDMRKS 1651
Score = 48.1 bits (113), Expect = 7e-05
Identities = 42/150 (28%), Positives = 60/150 (40%), Gaps = 21/150 (14%)
Query: 416 DVETNECLEN-NGGCWKDKAANITA--CKDTFR-----GRVCE-CPLVDGVQFKGDGYTT 466
D+ + C + NG C + A N+T C ++ R CE CP D
Sbjct: 1647 DMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNIGQAWNRPCEACP----TPISPDYQIL 1702
Query: 467 CEASGPG-RCKIKNGGCWHEARNGHAFSACVDD------GEVKCQCPAGFKGDGVK-NCQ 518
C PG I G G + C + G +C+CPAGF + + C+
Sbjct: 1703 CGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQIGSFRCECPAGFNYNSILLACE 1762
Query: 519 DVDECKEKKACQCPECSCKNTWGSYDCSCS 548
DVDEC +++ C N GSY C C+
Sbjct: 1763 DVDECGSRESPCQQNADCINIPGSYRCKCT 1792
Score = 47.0 bits (110), Expect = 2e-04
Identities = 47/175 (26%), Positives = 70/175 (39%), Gaps = 27/175 (15%)
Query: 402 GFEETTEPAVCLSSDVETNECLE--NNGGCWKDKAANIT------ACKDTFRGRVCE-CP 452
G T+ VC+ + V + C G C + +T A D G C+ CP
Sbjct: 601 GLAVGTDGRVCVDTHVRST-CYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCP 659
Query: 453 LVDGVQFK-----GDGYTTCEASGPGRCKIKNGGCWHEARNGHAFSACVD-DGEVKCQCP 506
+ +F+ G G TT + C + C A C + G +C C
Sbjct: 660 AKNSAEFQALCSSGLGITT-DGRDINECALDPEVC--------ANGVCENLRGSYRCVCN 710
Query: 507 AGFK-GDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDHDTC 560
G++ G K+C DVDEC + C C+N+ GSY CSC + +D + C
Sbjct: 711 LGYEAGASGKDCTDVDECA-LNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEIC 764
Score = 45.1 bits (105), Expect = 6e-04
Identities = 25/74 (33%), Positives = 33/74 (43%), Gaps = 9/74 (12%)
Query: 475 CKIKNGGCWHEARNGHAFSACVDDGEVKCQCPAGFKGDGV-KNCQDVDECKEKKACQCPE 533
CK+ G C H G C C GF D +NC D+DEC+ C +
Sbjct: 990 CKVFPGLCTHGTCRNTV-------GSFHCACAGGFALDAQERNCTDIDECRISPDL-CGQ 1041
Query: 534 CSCKNTWGSYDCSC 547
+C NT GS++C C
Sbjct: 1042 GTCVNTPGSFECEC 1055
Score = 43.9 bits (102), Expect = 0.001
Identities = 50/207 (24%), Positives = 70/207 (33%), Gaps = 44/207 (21%)
Query: 397 KAICS-GFEETTEPAVCLSSD-VETNECLENNGGCWKDKAANITACKDTFR----GRVC- 449
+ +C+ G+E C D N L +NG C + +C F +C
Sbjct: 706 RCVCNLGYEAGASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICK 765
Query: 450 ---EC---PLVDGVQFKGDGYTTCEASGPGR---------CKIKNGGCWHEARN------ 488
EC P V GV G TC+ GPG G CW + +
Sbjct: 766 DVDECLSSPCVSGVCRNLAGSYTCKC-GPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVN 824
Query: 489 --------------GHAFSACVDDGEVKCQCPAGFKGDGVKNCQDVDECKEKKACQCPEC 534
G A+ + + E+ C GF C DV+EC+ CP
Sbjct: 825 LQGASLRSECCATLGAAWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGV-CPNG 883
Query: 535 SCKNTWGSYDCSCSGDLLYIRDHDTCI 561
C NT GS+ C C L+ C+
Sbjct: 884 RCVNTAGSFRCECPEGLMLDASGRLCV 910
Score = 43.9 bits (102), Expect = 0.001
Identities = 23/56 (41%), Positives = 31/56 (55%), Gaps = 4/56 (7%)
Query: 495 CVDD-GEVKCQCPAGFKGDGV--KNCQDVDECKEKKACQCPECSCKNTWGSYDCSC 547
CV+ G +C+C G++ + KNC DVDEC + C +C NT GSY C C
Sbjct: 1044 CVNTPGSFECECFPGYESGFMLMKNCMDVDECA-RDPLLCRGGTCTNTDGSYKCQC 1098
Score = 43.5 bits (101), Expect = 0.002
Identities = 25/62 (40%), Positives = 33/62 (52%), Gaps = 4/62 (6%)
Query: 491 AFSACVD-DGEVKCQCPAGFKGD-GVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSCS 548
AF +C + G +C C G++ D G NC D++EC + C C NT GSY CSC
Sbjct: 1415 AFGSCENLPGMFRCICNGGYELDRGGGNCTDINECADP--VNCINGVCINTPGSYLCSCP 1472
Query: 549 GD 550
D
Sbjct: 1473 QD 1474
Score = 43.5 bits (101), Expect = 0.002
Identities = 35/110 (31%), Positives = 49/110 (43%), Gaps = 17/110 (15%)
Query: 440 CKDTFRGRVCECPLVDGVQFKGDGYTTCEASGPGRCKIKNGGCWHEARNGHAFSACVDD- 498
C++ G C CP G+T + S +C +N G A +C +
Sbjct: 2542 CQNQLGGYRCSCP---------QGFT--QHSQWAQCVDENECALSPPTCGSA--SCRNTL 2588
Query: 499 GEVKCQCPAGFKGD-GVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSC 547
G +C CP+GF D + CQDVDEC ++ C SC NT G + C C
Sbjct: 2589 GGFRCVCPSGFDFDQALGGCQDVDECAGRRG-PC-SYSCANTPGGFLCGC 2636
Score = 42.7 bits (99), Expect = 0.003
Identities = 45/168 (26%), Positives = 61/168 (35%), Gaps = 32/168 (19%)
Query: 417 VETNECLE-----NNGGCWKDKAANITACKDTFRGRVCE--CPLVDGVQFKGDGYTTCE- 468
V NEC E ++G C + + + C F+ + C +D + G TC+
Sbjct: 1804 VGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGTCKN 1863
Query: 469 -------ASGPGRCKIKNGGC----------WHEARNGHAFSACVDDGEVKCQCPAGFK- 510
PG NG C R GH + G C C GF+
Sbjct: 1864 IIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTA---GSFHCLCQDGFEL 1920
Query: 511 -GDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDH 557
DG KNC D +EC A C +C+N GS+ C C DH
Sbjct: 1921 TADG-KNCVDTNECLSL-AGTCLPGTCQNLEGSFRCICPPGFQVQSDH 1966
Score = 42.4 bits (98), Expect = 0.004
Identities = 25/74 (33%), Positives = 34/74 (45%), Gaps = 6/74 (8%)
Query: 488 NGHAFSACVDDGEVKCQCPAGFKG-DGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCS 546
NG +A G +C+C GF + + CQDVDEC + C SC+N G + C
Sbjct: 1375 NGQCLNA---PGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFG--SCENLPGMFRCI 1429
Query: 547 CSGDLLYIRDHDTC 560
C+G R C
Sbjct: 1430 CNGGYELDRGGGNC 1443
Score = 41.2 bits (95), Expect = 0.008
Identities = 37/132 (28%), Positives = 49/132 (37%), Gaps = 23/132 (17%)
Query: 418 ETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGYTTC-EASGPGRCK 476
+ +EC G C + T +FR CEC + G G E GP RC+
Sbjct: 2485 DNDECSAQPGPCGAHGHCHNTP--GSFR---CECHQGFTLVSSGHGCEDVNECDGPHRCQ 2539
Query: 477 IKNGGCWHEARNGHAFSACVDDGEVKCQCPAGFKGDGV-KNCQDVDECKEKKACQCPECS 535
GC ++ G +C CP GF C D +EC C S
Sbjct: 2540 ---HGCQNQL------------GGYRCSCPQGFTQHSQWAQCVDENECALSPPT-CGSAS 2583
Query: 536 CKNTWGSYDCSC 547
C+NT G + C C
Sbjct: 2584 CRNTLGGFRCVC 2595
Score = 40.8 bits (94), Expect = 0.011
Identities = 32/109 (29%), Positives = 42/109 (38%), Gaps = 16/109 (14%)
Query: 440 CKDTFRGRVCECPLVDGVQFKGDGYTTCEASGPGRCKIKNGGCWHEARNGHAFSACVDD- 498
CK+T +C CP G + DG T + C + C CV+
Sbjct: 2420 CKNTKGSFLCSCPR--GYLLEEDGRTCKDLD---ECTSRQHNCQF---------LCVNTV 2465
Query: 499 GEVKCQCPAGFKGDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSC 547
G C+CP GF + C D DEC + C NT GS+ C C
Sbjct: 2466 GAFTCRCPPGFTQHH-QACFDNDECSAQPGPCGAHGHCHNTPGSFRCEC 2513
Score = 40.0 bits (92), Expect = 0.019
Identities = 42/156 (26%), Positives = 58/156 (36%), Gaps = 33/156 (21%)
Query: 418 ETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGYTT----------- 466
+ NEC G C + N +FR CECP +G+ G
Sbjct: 869 DVNECESFPGVCPNGRCVNTAG---SFR---CECP--EGLMLDASGRLCVDVRLEPCFLR 920
Query: 467 -----CEASGPGRCKIKNGGCWHEARNGHAFSACVDDG--EVKCQCPAGFKG------DG 513
C + PG+ ++ C A G AC D E CP G G
Sbjct: 921 WDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSG 980
Query: 514 VKNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSG 549
+DV+ECK C +C+NT GS+ C+C+G
Sbjct: 981 RPFYKDVNECKVFPGL-CTHGTCRNTVGSFHCACAG 1015
Score = 39.3 bits (90), Expect = 0.032
Identities = 44/164 (26%), Positives = 64/164 (38%), Gaps = 32/164 (19%)
Query: 400 CSGFEETTEPAVCLSSDVETNECLENNGG----CWKDKAANITA--CKDTFRGRVCECPL 453
C+ E +P C++ C+ G C +D N + C DT G C
Sbjct: 1443 CTDINECADPVNCING-----VCINTPGSYLCSCPQDFELNPSGVGCVDTRAGN-CFLET 1496
Query: 454 VDGVQFKGDGYTTCEAS-GPG----RCKIKNGGCWHEARNGHAFSAC--VDDGEVKCQCP 506
D +GD +C A G G C G W G+ C + E + CP
Sbjct: 1497 HD----RGDSGISCSAEIGVGVTRASCCCSLGRAW-----GNPCELCPMANTTEYRTLCP 1547
Query: 507 AG--FKGDGVKNC-QDVDECKEKKACQCPECSCKNTWGSYDCSC 547
G F+ + + +D+DEC+E C C NT+GS+ C C
Sbjct: 1548 GGEGFQPNRITVILEDIDECQELPGL-CQGGDCVNTFGSFQCEC 1590
Score = 37.7 bits (86), Expect = 0.092
Identities = 17/46 (36%), Positives = 22/46 (46%), Gaps = 3/46 (6%)
Query: 502 KCQCPAGFKGDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSC 547
+C+C G+ D C DVDEC + C C N G+Y C C
Sbjct: 432 RCECNVGYTQDVRGECIDVDEC---TSSPCHHGDCVNIPGTYHCRC 474
Score = 36.6 bits (83), Expect = 0.21
Identities = 23/76 (30%), Positives = 30/76 (39%), Gaps = 7/76 (9%)
Query: 499 GEVKCQCPAGFKGDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSC------SGDLL 552
G +C+C G+K C +EC+E C C +T GSY C C S D
Sbjct: 1785 GSYRCKCTRGYKLSPGGACVGRNECREIPNV-CSHGDCMDTEGSYMCLCHRGFQASADQT 1843
Query: 553 YIRDHDTCISKTASQG 568
D D C + G
Sbjct: 1844 LCMDIDECDRQPCGNG 1859
Score = 35.4 bits (80), Expect = 0.46
Identities = 46/185 (24%), Positives = 64/185 (33%), Gaps = 46/185 (24%)
Query: 399 ICSGFEETTEPAVCLSSDVETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQ 458
+C+ + T P+ +S + N G C + A+ C+ + G VC P+ D
Sbjct: 100 LCTCADGTLAPSCGVSRGSGCSVSCMNGGTC---RGASCL-CQKGYTGTVCGQPICDRGC 155
Query: 459 FKGDGYTTCEASGPGRCKIKNG----GCWHEARNGHAFSACVDDG--------------- 499
G GP RC G C + R G F +G
Sbjct: 156 HNGG-----RCIGPNRCACVYGFMGPQCERDYRTGPCFGQVGPEGCQHQLTGLVCTKALC 210
Query: 500 --------EVKCQ-CPA-------GFKGD-GVKNCQDVDECKEKKACQCPECSCKNTWGS 542
+ C+ CPA GF + CQDVDEC+ C SC N GS
Sbjct: 211 CATVGRAWGLPCELCPAQPHPCRRGFIPNIHTGACQDVDECQAVPGL-CQGGSCVNMVGS 269
Query: 543 YDCSC 547
+ C C
Sbjct: 270 FHCRC 274
Score = 35.0 bits (79), Expect = 0.60
Identities = 40/151 (26%), Positives = 54/151 (35%), Gaps = 29/151 (19%)
Query: 402 GFEETTEPAVCLSSDVETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKG 461
GFE T + C V+TNECL G C N+ + +FR C CP G Q +
Sbjct: 1917 GFELTADGKNC----VDTNECLSLAGTCLPGTCQNL---EGSFR---CICP--PGFQVQS 1964
Query: 462 DGYTTCEASGPGRCKIKNGGCWHEARNGHAFSACVDD-GEVKCQCPAGF-KGDGVKNCQD 519
D + E N F C + G +C CP GF D C D
Sbjct: 1965 DHCIDIDECS-------------EEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCFD 2011
Query: 520 VDECKEKKACQCPECSCKNTWGSYD--CSCS 548
+ + +CS + + C CS
Sbjct: 2012 TRQSFCFTRFEAGKCSVPKAFNTTKTRCCCS 2042
>EFL3_HUMAN (O75095) Multiple EGF-like-domain protein 3 (Multiple
epidermal growth factor-like domains 6) (Fragment)
Length = 1246
Score = 60.5 bits (145), Expect = 1e-08
Identities = 52/165 (31%), Positives = 70/165 (41%), Gaps = 28/165 (16%)
Query: 385 QYRGKLEKGAVMKAICSGFEETTEPAVCLSSDVETNECLENNGGCWKDKAANITACKDTF 444
Q+R G+ + GF T+ CL+ N C NGGC + +T +
Sbjct: 85 QHRCVNTPGSYLCECKPGFRLHTDSRTCLA----INSCALGNGGC-QHHCVQLTITRHR- 138
Query: 445 RGRVCECPLVDGVQFKGDGYTTCEASGPGRCKIKNGGCWHEARNGHAFSACVDDGEVKCQ 504
C+C G Q + DG C P C +NG C H + V G +C+
Sbjct: 139 ----CQCR--PGFQLQEDG-RHCVRRSP--CANRNGSCMHRCQ--------VVRGLARCE 181
Query: 505 CPAGFK--GDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSC 547
C G++ DG K C+DVDEC A QC C NT GS+ C C
Sbjct: 182 CHVGYQLAADG-KACEDVDECAAGLA-QCAH-GCLNTQGSFKCVC 223
Score = 55.8 bits (133), Expect = 3e-07
Identities = 50/179 (27%), Positives = 69/179 (37%), Gaps = 32/179 (17%)
Query: 388 GKLEKGAVMKAIC-SGFEETTEPAVCLSSDVE-TNECLENNGGCWKDKAANITACKDTFR 445
G L K +C +G+E + C ++E N C NNGGC C T
Sbjct: 211 GCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGC-------SHGCSHTSA 263
Query: 446 GRVCECPLVDGVQFKGDGYTTCEASGPGRCKIKNGGCWHEARNGHAFSACVDD-GEVKCQ 504
G +C CP G + D T + + C + C ++ G +C
Sbjct: 264 GPLCTCP--RGYELDTDQRTCIDVD-----DCADSPCCQQ--------VCTNNPGGYECG 308
Query: 505 CPAGFK--GDGVKNCQDVDECKEKK-ACQCPECSCKNTWGSYDCSCSGDLLYIRDHDTC 560
C AG++ DG C+DVDEC + C E C N GS+ CSC D C
Sbjct: 309 CYAGYRLSADGC-GCEDVDECASSRGGC---EHHCTNLAGSFQCSCEAGYRLHEDRRGC 363
Score = 33.9 bits (76), Expect = 1.3
Identities = 37/143 (25%), Positives = 46/143 (31%), Gaps = 45/143 (31%)
Query: 412 CLSSDVETNECLENNGGCWKDKAANITACKDTFRGRVC--ECPLVDGVQFKGDGYTTCEA 469
C T C + +G C +CK FRG C EC L GY
Sbjct: 566 CQCVQPHTQSCDKRDGSC---------SCKAGFRGERCQAECEL---------GY----- 602
Query: 470 SGPGRCKIKNGGCWHEARNGHAFSACVDDGEVKCQCPAGFKGDGVKNCQDVDECKE---- 525
GP GCW + GE +CPAGF+G+ +C EC
Sbjct: 603 FGP--------GCWQACTCPVGVACDSVSGECGKRCPAGFQGE---DCG--QECPVGTFG 649
Query: 526 ---KKACQCPECSCKNTWGSYDC 545
+C C C G C
Sbjct: 650 VNCSSSCSCGGAPCHGVTGQCRC 672
Score = 31.6 bits (70), Expect = 6.6
Identities = 20/57 (35%), Positives = 24/57 (42%), Gaps = 4/57 (7%)
Query: 507 AGFKGDGVKNCQDVDECKEKKA-CQCPECSCKNTWGSYDCSCSGDLLYIRDHDTCIS 562
AG+ DVDEC+ CQ C NT GSY C C D TC++
Sbjct: 61 AGYPVSAGDQRPDVDECRTHNGGCQH---RCVNTPGSYLCECKPGFRLHTDSRTCLA 114
>FBN1_PIG (Q9TV36) Fibrillin 1 precursor
Length = 2871
Score = 59.7 bits (143), Expect = 2e-08
Identities = 51/170 (30%), Positives = 67/170 (39%), Gaps = 29/170 (17%)
Query: 397 KAIC-SGFEETTEPAVCLSSDVETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVD 455
+ +C GF + + C V+ NEC N C C++T +C C +
Sbjct: 1262 RCLCYDGFMASEDMKTC----VDVNECDLNPNICLSG------TCENTKGSFICHCDM-- 1309
Query: 456 GVQFKGDGYTTCEASGPGRCKIKNGGCWHEARNGHAFSACVDD-GEVKCQCPAGFKGDGV 514
G K G T C + C+I C A C + G C C G+ GDG+
Sbjct: 1310 GYSGK-KGKTGC--TDINECEIGAHNCDRHA-------VCTNTAGSFNCSCSPGWIGDGI 1359
Query: 515 KNCQDVDECKEKKACQCPECSCKNTWGSYDCSC----SGDLLYIRDHDTC 560
K C D+DEC CKNT GSY C C +GD D D C
Sbjct: 1360 K-CTDLDECSNGTHMCSQHADCKNTMGSYRCLCKEGYTGDGFTCADLDEC 1408
Score = 52.4 bits (124), Expect = 4e-06
Identities = 52/167 (31%), Positives = 69/167 (41%), Gaps = 38/167 (22%)
Query: 420 NECLENNGG-CWKDKAANIT--------------ACKDTFRG--RVCE-CPLVDGVQFK- 460
+ECL+N G C+ + N+ C D RG CE CP V FK
Sbjct: 2329 DECLDNREGYCFTEVLQNMCQIGSSNRNPVTKSECCCDGGRGWGPHCEICPFQGTVAFKK 2388
Query: 461 ----GDGYTTCEASGPGRCKIKNGGCWHEARNGHAFSACVDD-GEVKCQCPAGFKGDGVK 515
G G+ T + CK+ + C RNG C++D G C C G+ D
Sbjct: 2389 LCPHGRGFMT-NGADIDECKVIHDVC----RNGE----CINDRGSYHCICKTGYTPDITG 2439
Query: 516 N-CQDVDECKEK-KACQCPECSCKNTWGSYDCSCSGDLLYIRDHDTC 560
C D++EC + K C CKNT GSY CSC + D +C
Sbjct: 2440 TACVDLNECNQAPKPCNF---ICKNTEGSYQCSCPKGYILQEDGRSC 2483
Score = 51.2 bits (121), Expect = 8e-06
Identities = 44/159 (27%), Positives = 65/159 (40%), Gaps = 29/159 (18%)
Query: 417 VETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGYTTCE-----ASG 471
+E NEC++ + + N T CK+ G C C +G F+ TCE A
Sbjct: 2159 LEGNECVDTDECSVGNPCGNGT-CKNVIGGFECTCE--EG--FEPGPMMTCEDINECAQN 2213
Query: 472 PGRCKIKNGGCWHEARNGHAFSACVDD-GEVKCQCPAGFK-GDGVKNCQDVDECKE-KKA 528
P C + CV+ G +C+CP G+ + + C+D DEC+E K
Sbjct: 2214 PLLCAFR----------------CVNTYGSYECKCPTGYVLREDRRMCKDEDECEEGKHD 2257
Query: 529 CQCPECSCKNTWGSYDCSCSGDLLYIRDHDTCISKTASQ 567
C + CKN G Y C C D + C+ + Q
Sbjct: 2258 CAEKQMECKNLIGMYICICGPGYQRRPDGEGCVDENECQ 2296
Score = 50.8 bits (120), Expect = 1e-05
Identities = 49/162 (30%), Positives = 63/162 (38%), Gaps = 28/162 (17%)
Query: 402 GFEETTEPAVCLSSDVETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKG 461
G++ T C D ECL+N C N C +T C C G
Sbjct: 518 GYQSTLTRTECRDID----ECLQNGRIC------NNGRCINTDGSFHCVCNA--GFHVTR 565
Query: 462 DGYTTCEASGPGRCKIKNGGCWHEARNGHAFSACVDDGEVKCQCPAGFK--GDGVKNCQD 519
DG CE C I+N NG + +DG KC C GF+ DG + C+D
Sbjct: 566 DG-KNCEDMD--ECSIRN-----MCLNGMCIN---EDGSFKCICKPGFQLASDG-RYCKD 613
Query: 520 VDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDHDTCI 561
++EC+ C C NT GSY C C L D C+
Sbjct: 614 INECETSGICM--NGRCVNTDGSYRCECFPGLAVGLDGRVCV 653
Score = 49.3 bits (116), Expect = 3e-05
Identities = 24/63 (38%), Positives = 34/63 (53%), Gaps = 2/63 (3%)
Query: 499 GEVKCQCPAGFKGDGV-KNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDH 557
G KC C +G++ D KNC D++EC + C C+NT GS+ C+C +Y D
Sbjct: 744 GTYKCICNSGYEVDSTGKNCVDINECV-LNSLLCDNGQCRNTPGSFVCTCPKGFIYKPDL 802
Query: 558 DTC 560
TC
Sbjct: 803 KTC 805
Score = 48.1 bits (113), Expect = 7e-05
Identities = 27/88 (30%), Positives = 36/88 (40%), Gaps = 10/88 (11%)
Query: 475 CKIKNGGCWHEARNGHAFSACVDDGEVKCQCPAGFK-GDGVKNCQDVDECKEKKACQCPE 533
C I NGGC N +G +C C GF ++C D+DEC++ C
Sbjct: 1201 CSIMNGGCETFCTNS--------EGSYECSCQPGFALMPDQRSCTDIDECEDNPNI-CDG 1251
Query: 534 CSCKNTWGSYDCSCSGDLLYIRDHDTCI 561
C N G Y C C + D TC+
Sbjct: 1252 GQCTNIPGEYRCLCYDGFMASEDMKTCV 1279
Score = 48.1 bits (113), Expect = 7e-05
Identities = 48/178 (26%), Positives = 69/178 (37%), Gaps = 46/178 (25%)
Query: 417 VETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGYTTCE-------- 468
V+ +EC E G C N+ +FR CECP+ F D CE
Sbjct: 1765 VDIDECREIPGVCENGVCINMVG---SFR---CECPVGF---FYNDKLLVCEDIDECQNG 1815
Query: 469 -----------ASGPGRCKIK-------NGGC-----WHEARNGHAFSACVDD-GEVKCQ 504
+G RC K G C E N + C+D G C
Sbjct: 1816 PVCQRNAECINTAGSYRCDCKPGYRFTSTGQCNDRNECQEIPNICSHGQCIDTVGSFYCL 1875
Query: 505 CPAGFKGDGVKN-CQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDHDTCI 561
C GFK + + C D++EC+ C +C+NT GS++C C+ + ++D CI
Sbjct: 1876 CHTGFKTNADQTMCLDINECERDA---CGNGTCRNTIGSFNCRCNHGFILSHNND-CI 1929
Score = 47.8 bits (112), Expect = 9e-05
Identities = 36/126 (28%), Positives = 50/126 (39%), Gaps = 19/126 (15%)
Query: 440 CKDTFRGRVCECPLVDGVQFKGDGYTTCEASGPGRCKIKNGGCWHEARNGHAFSACVDD- 498
C +T C+CP G+T + C I N C + A C +
Sbjct: 2500 CVNTIGSFACKCP---------PGFTQHHTA----C-IDNNECTSDINLCGAKGICQNTP 2545
Query: 499 GEVKCQCPAGFKGD-GVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDH 557
G C+C GF D +C+DVDEC+ CQ C+N G Y CSC L
Sbjct: 2546 GSFTCECQRGFSLDQSGASCEDVDECEGNHRCQH---GCQNIIGGYRCSCPQGYLQHYQW 2602
Query: 558 DTCISK 563
+ C+ +
Sbjct: 2603 NQCVDE 2608
Score = 47.4 bits (111), Expect = 1e-04
Identities = 45/166 (27%), Positives = 62/166 (37%), Gaps = 49/166 (29%)
Query: 417 VETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKG---DGYTTCEAS--- 470
++ NEC + C A I C++T CEC + G + CE +
Sbjct: 2523 IDNNECTSDINLCG---AKGI--CQNTPGSFTCECQRGFSLDQSGASCEDVDECEGNHRC 2577
Query: 471 --------GPGRCKIKNGGCWHEARNGHAFSACVDD------------------GEVKCQ 504
G RC G H + ++ CVD+ G KC
Sbjct: 2578 QHGCQNIIGGYRCSCPQGYLQH-----YQWNQCVDENECLSAHICGGASCHNTLGSYKCM 2632
Query: 505 CPAGFKGDGVKN-CQDVDECKEKKACQCPECS--CKNTWGSYDCSC 547
CPAGF+ + CQD++EC +A CS C NT G Y C C
Sbjct: 2633 CPAGFQYEQFSGGCQDINECGSSQA----PCSYGCSNTEGGYLCGC 2674
Score = 46.6 bits (109), Expect = 2e-04
Identities = 23/77 (29%), Positives = 38/77 (48%), Gaps = 3/77 (3%)
Query: 499 GEVKCQCPAGFK-GDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDH 557
G +C+CP G+ + + C DV+EC+ C +C NT G+Y C C D + +
Sbjct: 1627 GSFQCRCPTGYYLNEDTRVCDDVNECETPGICG--PGTCYNTVGNYTCICPPDYMQVNGG 1684
Query: 558 DTCISKTASQGGRSAWA 574
+ C+ S R+ +A
Sbjct: 1685 NNCMDMRRSLCYRNYYA 1701
Score = 46.6 bits (109), Expect = 2e-04
Identities = 34/133 (25%), Positives = 53/133 (39%), Gaps = 21/133 (15%)
Query: 440 CKDTFRGRVCECPLVDGVQFKGDGYTTCEASGPGRCKIKNGGCWHEARNGHAFSACVDDG 499
C +T CECP G +G+ E C + N NG + G
Sbjct: 2142 CINTDGSYRCECPF--GYILEGN-----ECVDTDECSVGN-----PCGNGTCKNVI---G 2186
Query: 500 EVKCQCPAGFKGDGVKNCQDVDECKEKKACQCPECS--CKNTWGSYDCSCSGDLLYIRDH 557
+C C GF+ + C+D++EC + C+ C NT+GSY+C C + D
Sbjct: 2187 GFECTCEEGFEPGPMMTCEDINECAQNPLL----CAFRCVNTYGSYECKCPTGYVLREDR 2242
Query: 558 DTCISKTASQGGR 570
C + + G+
Sbjct: 2243 RMCKDEDECEEGK 2255
Score = 46.2 bits (108), Expect = 3e-04
Identities = 43/143 (30%), Positives = 55/143 (38%), Gaps = 38/143 (26%)
Query: 440 CKDTFRGRVCECPLVDGVQFKGDGYTTCEAS---------GPGRCKIKNGGCWHEARNGH 490
CK+T C C +G + GDG+T + G +C GG E G
Sbjct: 1380 CKNTMGSYRCLCK--EG--YTGDGFTCADLDECSENVKLCGNVQCLYAPGGYHCEYDMGF 1435
Query: 491 AFSA----CVDDGEV------------------KCQCPAGFKGD-GVKNCQDVDECKEKK 527
SA CVD E +C+C G++ D NC DV+EC E
Sbjct: 1436 VPSADRKSCVDSDECSLPNICVFGTCHNLPGLFRCECEIGYELDRSGGNCTDVNECLEPP 1495
Query: 528 ACQCPECSCKNTWGSYDCSCSGD 550
C +C NT GSY C C D
Sbjct: 1496 TCISG--NCVNTPGSYTCVCPPD 1516
Score = 45.8 bits (107), Expect = 3e-04
Identities = 51/178 (28%), Positives = 68/178 (37%), Gaps = 43/178 (24%)
Query: 425 NNGGCWKDKAANITACKDTF----RGR---VCEC---PLVDGVQFKGDGYTTCEASGPG- 473
+NG C + C F RG V EC P G G TC+ PG
Sbjct: 461 HNGRCIPTPGSYRCECNKGFQLDLRGECIDVDECEKNPCAGGECINNQGSYTCQCR-PGY 519
Query: 474 -------RCK-----IKNGGCWHEARNGHAFSACVD-DGEVKCQCPAGFK--GDGVKNCQ 518
C+ ++NG + R C++ DG C C AGF DG KNC+
Sbjct: 520 QSTLTRTECRDIDECLQNGRICNNGR-------CINTDGSFHCVCNAGFHVTRDG-KNCE 571
Query: 519 DVDECKEKKACQCPECSCKNTWGSYDCSC------SGDLLYIRDHDTCISKTASQGGR 570
D+DEC + C C N GS+ C C + D Y +D + C + GR
Sbjct: 572 DMDECSIRN--MCLNGMCINEDGSFKCICKPGFQLASDGRYCKDINECETSGICMNGR 627
Score = 45.4 bits (106), Expect = 4e-04
Identities = 22/63 (34%), Positives = 27/63 (41%)
Query: 499 GEVKCQCPAGFKGDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDHD 558
G C+C GF +C DVDEC C C NT GS+ C C+ D
Sbjct: 1910 GSFNCRCNHGFILSHNNDCIDVDECATGNGNLCRNGQCINTVGSFQCQCNEGYEVAPDGR 1969
Query: 559 TCI 561
TC+
Sbjct: 1970 TCV 1972
Score = 45.4 bits (106), Expect = 4e-04
Identities = 24/64 (37%), Positives = 30/64 (46%), Gaps = 2/64 (3%)
Query: 499 GEVKCQCPAGFKGDGV-KNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDH 557
G +C+CPAG K + V + C+D+DEC C C NT SY C C D
Sbjct: 267 GSFECKCPAGHKFNEVSQKCEDIDECSTIPGI-CDGGECTNTVSSYFCKCPPGFYTSPDG 325
Query: 558 DTCI 561
CI
Sbjct: 326 TRCI 329
Score = 45.4 bits (106), Expect = 4e-04
Identities = 23/54 (42%), Positives = 30/54 (54%), Gaps = 6/54 (11%)
Query: 499 GEVKCQCPAGF--KGDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGD 550
G C CP GF K D +K C+D+DEC+ C CKN+ GS+ C CS +
Sbjct: 786 GSFVCTCPKGFIYKPD-LKTCEDIDECESSP---CINGVCKNSPGSFICECSSE 835
Score = 44.7 bits (104), Expect = 8e-04
Identities = 22/56 (39%), Positives = 32/56 (56%), Gaps = 4/56 (7%)
Query: 495 CVDD-GEVKCQCPAGFKGDGV--KNCQDVDECKEKKACQCPECSCKNTWGSYDCSC 547
CV+ G+ +C+C G++ + KNC D+DEC ++ C C NT GSY C C
Sbjct: 1086 CVNTPGDFECKCDEGYESGFMMMKNCMDIDEC-QRDPLLCRGGVCLNTEGSYRCEC 1140
Score = 44.3 bits (103), Expect = 0.001
Identities = 51/178 (28%), Positives = 66/178 (36%), Gaps = 33/178 (18%)
Query: 400 CSGFEETTEPAVCLSSDVETNECLENNGG----CWKDKAANIT--ACKDTFRGRVCECPL 453
C+ E EP C+S + C+ G C D N T C DT G C L
Sbjct: 1485 CTDVNECLEPPTCISGN-----CVNTPGSYTCVCPPDFELNPTRVGCVDTRSGN---CYL 1536
Query: 454 VDGVQFKGD-GYTTCEAS-----GPGRCKIKNGGCWHEARNGHAFSAC--VDDGEVKCQC 505
V+ +GD G T C C G W G C V+ E K C
Sbjct: 1537 --DVRPRGDNGDTACSNEIGVGVSKASCCCSLGKAW-----GTPCEQCPPVNTSEYKILC 1589
Query: 506 PAG--FKGDGVKNC-QDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDHDTC 560
P G F+ + + +D+DEC+E C C NT+GS+ C C D C
Sbjct: 1590 PGGEGFRPNPITVILEDIDECQELPGL-CQGGKCINTFGSFQCRCPTGYYLNEDTRVC 1646
Score = 44.3 bits (103), Expect = 0.001
Identities = 33/112 (29%), Positives = 48/112 (42%), Gaps = 23/112 (20%)
Query: 450 ECPLVDGVQF-----KGDGYTTCEASGP-------GRCKIKNGGCWH-EARNGHAFSACV 496
ECP + ++ +G G+ T E + CK+ C H + RN
Sbjct: 995 ECPPRNTPEYEELCPRGPGFATKEITNGKPFFKDINECKMIPNLCTHGKCRN-------- 1046
Query: 497 DDGEVKCQCPAGFKGDGV-KNCQDVDECKEKKACQCPECSCKNTWGSYDCSC 547
G KC+C +GF D +NC D+DEC+ C C NT G ++C C
Sbjct: 1047 TIGSFKCRCDSGFALDSEERNCIDIDECRISPDL-CGRGQCVNTPGDFECKC 1097
Score = 43.9 bits (102), Expect = 0.001
Identities = 49/196 (25%), Positives = 69/196 (35%), Gaps = 50/196 (25%)
Query: 397 KAIC-SGFEETTEPAVCLSSDVETNECLEN-----NGGCWKDKAANITACKDTFRGR--- 447
K IC SG+E + C V+ NEC+ N NG C + + C F +
Sbjct: 747 KCICNSGYEVDSTGKNC----VDINECVLNSLLCDNGQCRNTPGSFVCTCPKGFIYKPDL 802
Query: 448 -----VCEC---PLVDGVQFKGDGYTTCEASGP------------------------GRC 475
+ EC P ++GV G CE S GRC
Sbjct: 803 KTCEDIDECESSPCINGVCKNSPGSFICECSSESTLDPTKTICIETIKGTCWQTIIDGRC 862
Query: 476 KIKNGGCWHEARNGHAFSACVDDGEVKCQ----CPAGFKGDGVKNCQDVDECKEKKACQC 531
+I G +++ + A CQ C G+ C+D+DEC E C
Sbjct: 863 EININGATLKSQCCSSLGAAWGSPCTPCQVDPICGKGYSRIKGTQCEDIDEC-EVFPGVC 921
Query: 532 PECSCKNTWGSYDCSC 547
C N+ GS+ C C
Sbjct: 922 KNGLCVNSKGSFKCQC 937
Score = 42.4 bits (98), Expect = 0.004
Identities = 47/176 (26%), Positives = 65/176 (36%), Gaps = 36/176 (20%)
Query: 397 KAICSGFE----ETTEPAVCLSSDVETNECLENNGGCWKDKAANITACKDTFRGRVCECP 452
K + GFE E EP ++ + + NEC +N C C +T+ C+CP
Sbjct: 2182 KNVIGGFECTCEEGFEPGPMMTCE-DINECAQNPLLC-------AFRCVNTYGSYECKCP 2233
Query: 453 LVDGVQFKGD-----GYTTCEASGPGRCKIKNGGCWHEARNGHAFSACVDDGEVKCQCPA 507
G + D CE G C K C + G C C
Sbjct: 2234 T--GYVLREDRRMCKDEDECE-EGKHDCAEKQMECKNLI------------GMYICICGP 2278
Query: 508 GF--KGDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDHDTCI 561
G+ + DG + C D +EC+ K C C NT GSY C C+ D C+
Sbjct: 2279 GYQRRPDG-EGCVDENECQTKPGI-CENGRCLNTRGSYTCECNDGFTASPTQDECL 2332
Score = 39.7 bits (91), Expect = 0.024
Identities = 41/128 (32%), Positives = 47/128 (36%), Gaps = 10/128 (7%)
Query: 422 CLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGYTTCEASGPGRCKIKNGG 481
CL N G C A N AC F G CE G F C+ G K
Sbjct: 154 CL-NGGRC---VAPNRCACTYGFTGPQCERDYRTGPCFTVVSNQMCQGQLSGIVCTKTLC 209
Query: 482 CWHEARN-GHAFSACVDDGEVKCQCPAGFKGD-GVKNCQDVDECKEKKACQCPECSCKNT 539
C R GH C C GF + CQDVDEC+ C +C NT
Sbjct: 210 CATVGRAWGHPCEMCPAQPH---PCRRGFIPNIRTGACQDVDECQAIPGL-CQGGNCINT 265
Query: 540 WGSYDCSC 547
GS++C C
Sbjct: 266 VGSFECKC 273
Score = 39.3 bits (90), Expect = 0.032
Identities = 50/200 (25%), Positives = 72/200 (36%), Gaps = 41/200 (20%)
Query: 390 LEKGAVMKAICSGFEETTE----PAVCLSSDV--ETNECLENNGGCWKDKAANITACKDT 443
LE G C + + P L +D + +EC+E C + C +T
Sbjct: 1979 LEPGKCAPGTCQNLDGSYRCICPPGYSLQNDKCEDIDECVEEPEIC------ALGTCSNT 2032
Query: 444 FRGRVCECPLVDGVQFKGDGYTTCEASGPGRC--KIKNGGCWHEARNGHAFSACV----- 496
C CP DG G C+ C K + G C H+ C
Sbjct: 2033 EGSFKCLCP--DGFSLSSTG-RRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQECCCALKG 2089
Query: 497 DDGEVKCQ-CPA----GFK-----GDGV-----KNCQDVDECKEKKACQCPECSCKNTWG 541
+ C+ CP F+ G G+ + D+DECKE C+ +C NT G
Sbjct: 2090 EGWGDPCELCPTEPDEAFRQICPYGSGIIVGPDDSAVDMDECKEPDVCKHGQCI--NTDG 2147
Query: 542 SYDCSCSGDLLYIRDHDTCI 561
SY C C YI + + C+
Sbjct: 2148 SYRCEC--PFGYILEGNECV 2165
Score = 36.6 bits (83), Expect = 0.21
Identities = 26/105 (24%), Positives = 38/105 (35%), Gaps = 43/105 (40%)
Query: 498 DGEVKCQCPAGFK-GDGVKNCQDVDECKEKKACQCP------------------------ 532
+G +C+CP+G + + C D++EC E A CP
Sbjct: 1133 EGSYRCECPSGHQMSPNISACIDINEC-ELSAHLCPHGRCVNLIGKYQRARNPGYHSTPD 1191
Query: 533 --------ECS---------CKNTWGSYDCSCSGDLLYIRDHDTC 560
ECS C N+ GSY+CSC + D +C
Sbjct: 1192 RLFCVDIDECSIMNGGCETFCTNSEGSYECSCQPGFALMPDQRSC 1236
Score = 31.6 bits (70), Expect = 6.6
Identities = 42/159 (26%), Positives = 56/159 (34%), Gaps = 45/159 (28%)
Query: 422 CLEN-NGGCWK---DKAANITACKDTFRGRVCE---------CPLVDGVQFKGDGY---- 464
C+E G CW+ D I T + + C C G GY
Sbjct: 845 CIETIKGTCWQTIIDGRCEININGATLKSQCCSSLGAAWGSPCTPCQVDPICGKGYSRIK 904
Query: 465 -TTCEASGPGRCKIKNGGCWHEARNGHAFSACVDD-GEVKCQCPAGFKGDGV-KNCQDV- 520
T CE C++ G C +NG CV+ G KCQCP G D + C D+
Sbjct: 905 GTQCEDID--ECEVFPGVC----KNG----LCVNSKGSFKCQCPNGMTLDATGRICLDIR 954
Query: 521 -DEC---KEKKACQCPE----------CSCKNTWGSYDC 545
+ C E + C P CS WG+ +C
Sbjct: 955 LETCFLRYEDEECTLPVVGRHRMDACCCSVGAAWGTEEC 993
>LTB4_MOUSE (Q8K4G1) Latent transforming growth factor beta binding
protein 4 precursor (LTBP-4)
Length = 1666
Score = 59.3 bits (142), Expect = 3e-08
Identities = 49/169 (28%), Positives = 66/169 (38%), Gaps = 39/169 (23%)
Query: 387 RGKLEK--GAVMKAICSGFEETTEPAVCLSSDVETNECLENNGGCWKDKAANITA----- 439
RG+ E G+ + +G++ A C D EC ++ G C + N+
Sbjct: 685 RGRCENTPGSFLCVCPAGYQAAPHGASCQDVD----ECTQSPGLCGRGVCENLPGSFRCV 740
Query: 440 CKDTFRGRVCECPLVDGVQFKGDGYTTCEASGPGRCKIKNGGCWHEARNGHAFSACVDDG 499
C FRG CE + + Q GPGRC G +H
Sbjct: 741 CPAGFRGSACEEDVDECAQQP-------PPCGPGRCD-NTAGSFH--------------- 777
Query: 500 EVKCQCPAGFKGDGV-KNCQDVDECKEKKACQCPECSCKNTWGSYDCSC 547
C CPAGF+ G CQDVDEC + C C+NT GS+ C C
Sbjct: 778 ---CACPAGFRSRGPGAPCQDVDECSRSPS-PCAYGRCENTEGSFKCVC 822
Score = 48.5 bits (114), Expect = 5e-05
Identities = 44/157 (28%), Positives = 64/157 (40%), Gaps = 36/157 (22%)
Query: 397 KAIC-SGFEETTEPAVCLSSDVETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVD 455
+ +C +GF+ CL D EC C + + C++T +C CP
Sbjct: 654 RCVCGTGFQAGPRATECLDVD----ECRRVPPPCDRGR------CENTPGSFLCVCPA-- 701
Query: 456 GVQFKGDGYTTCE-----ASGPGRCKIKNGGCWHEARNGHAFSACVDDGEVKCQCPAGFK 510
G Q G +C+ PG C G C + G +C CPAGF+
Sbjct: 702 GYQAAPHG-ASCQDVDECTQSPGLCG--RGVCENLP------------GSFRCVCPAGFR 746
Query: 511 GDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSC 547
G + +DVDEC ++ C C NT GS+ C+C
Sbjct: 747 GSACE--EDVDECAQQPP-PCGPGRCDNTAGSFHCAC 780
Score = 43.9 bits (102), Expect = 0.001
Identities = 24/59 (40%), Positives = 29/59 (48%), Gaps = 3/59 (5%)
Query: 505 CPAGFKGDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDHDTCISK 563
CP GF+ +C DVDEC CQ EC+ NT G Y C C L +CIS+
Sbjct: 343 CPPGFERVN-GSCVDVDECATGGRCQHGECA--NTRGGYTCVCPDGFLLDSSRSSCISQ 398
Score = 43.1 bits (100), Expect = 0.002
Identities = 38/151 (25%), Positives = 52/151 (34%), Gaps = 24/151 (15%)
Query: 402 GFEETTEPAVCLSSDVETNECLENNGGCWKDKAANITACKDTFRGR--VCECPLVDGVQF 459
G+ A CL D + E L +G C + C R + C +D
Sbjct: 950 GYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDID---- 1005
Query: 460 KGDGYTTCEASGPGRCKIKNGGCWHEARNGHAFSACVDDGEVKCQCPAGFKGDGVKNCQD 519
C GP C + N CV D C G+ C D
Sbjct: 1006 ------ECRERGPALCGSQR------CENSPGSYRCVRD------CDPGYHPGPEGTCDD 1047
Query: 520 VDECKEKKACQCPECSCKNTWGSYDCSCSGD 550
+DEC+E + C C+NT GSY C+ + D
Sbjct: 1048 IDECREYGSAICGAQRCENTPGSYRCTPACD 1078
Score = 42.7 bits (99), Expect = 0.003
Identities = 31/92 (33%), Positives = 43/92 (46%), Gaps = 10/92 (10%)
Query: 464 YTTCEASGPGRCKIKNGGCWH--EARNGH---AFSACVD-DGEVKCQCPAGFKG--DGVK 515
Y A PG GGC E RN A + C + G +C C G++G DG +
Sbjct: 1071 YRCTPACDPGYQPTPGGGCQDVDECRNRSFCGAHAMCQNLPGSFQCVCDQGYEGARDG-R 1129
Query: 516 NCQDVDECKEKKACQCPECSCKNTWGSYDCSC 547
+C DV+EC+ + C C+N GS+ C C
Sbjct: 1130 HCVDVNECETLQGV-CGSALCENVEGSFLCVC 1160
Score = 38.9 bits (89), Expect = 0.041
Identities = 41/170 (24%), Positives = 64/170 (37%), Gaps = 29/170 (17%)
Query: 405 ETTEPAVC---LSSDVETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFK- 460
+T P C L+ +V EC G W + C R+ +CP + +++
Sbjct: 1228 DTAAPDACDNILARNVTWQECCCTVGEGWG------SGC------RIQQCPGTETAEYQS 1275
Query: 461 ----GDGYTTCEASGPGRCKIKNGGCWHE--ARNGHAFSACVDDGE-VKCQCPAGFKGDG 513
G GY R + + + ++G CV+ C C GF
Sbjct: 1276 LCPHGRGYLVPSGDLSARRDVDECQLFQDQVCKSG----VCVNTAPGYSCYCSNGFYYHA 1331
Query: 514 VK-NCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDHDTCIS 562
+ C D DEC +++ C C NT GSY C+C L+ C+S
Sbjct: 1332 HRLECVDNDECADEEPA-CEGGRCVNTVGSYHCTCEPPLVLDGSRRRCVS 1380
Score = 38.9 bits (89), Expect = 0.041
Identities = 18/52 (34%), Positives = 26/52 (49%), Gaps = 3/52 (5%)
Query: 499 GEVKCQCPAGFKGDGVKN--CQDVDECKEKKACQCPECSCKNTWGSYDCSCS 548
G C C G++ + C D++EC E C P C NT GS+ C+C+
Sbjct: 898 GSFHCSCSTGYRAPSGQPGPCADINECLEGDFC-FPHGECLNTDGSFTCTCA 948
Score = 38.5 bits (88), Expect = 0.054
Identities = 24/81 (29%), Positives = 32/81 (38%), Gaps = 21/81 (25%)
Query: 468 EASGPGRCKIKNGGCWHEARNGHAFSACVDDGEVKCQCPAGFK-GDGVKNCQDVDECKEK 526
+ GPGRC + G C C GF+ G C D+DEC+ +
Sbjct: 597 QVCGPGRCVPRPSG-------------------YTCACDPGFRLGPQDTRCIDIDECR-R 636
Query: 527 KACQCPECSCKNTWGSYDCSC 547
C C+NT GS+ C C
Sbjct: 637 VPTPCAPGRCENTPGSFRCVC 657
Score = 37.0 bits (84), Expect = 0.16
Identities = 19/48 (39%), Positives = 26/48 (53%), Gaps = 3/48 (6%)
Query: 503 CQCPAGFKGDGVK-NCQDVDECKEKKACQ--CPECSCKNTWGSYDCSC 547
C C G++ D + +C DV+EC E +A C C NT GS+ C C
Sbjct: 1599 CDCFDGYRLDITRMSCVDVNECDEAEATSPLCINARCVNTDGSFRCIC 1646
Score = 34.3 bits (77), Expect = 1.0
Identities = 21/60 (35%), Positives = 27/60 (45%), Gaps = 7/60 (11%)
Query: 518 QDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLY------IRDHDTCI-SKTASQGGR 570
+DVDEC+ + C C NT Y C CS Y D+D C + A +GGR
Sbjct: 1294 RDVDECQLFQDQVCKSGVCVNTAPGYSCYCSNGFYYHAHRLECVDNDECADEEPACEGGR 1353
>UROM_BOVIN (P48733) Uromodulin precursor (Tamm-Horsfall urinary
glycoprotein) (THP)
Length = 643
Score = 58.9 bits (141), Expect = 4e-08
Identities = 46/157 (29%), Positives = 58/157 (36%), Gaps = 27/157 (17%)
Query: 414 SSDVETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGYTTCEASGPG 473
SS +EC +N C D AA AC++ F G EC +D C G
Sbjct: 29 SSAKSCSEC-HSNATCTVDGAATTCACQEGFTGDGLECVDLD----------ECAVLGAH 77
Query: 474 RCKIKNGGCWHEARNGHAFSACVDD-GEVKCQCPAGFKGDGVKNCQDVDECKEKKACQCP 532
C A +CV+ G C CP GF C+DVDEC E +C
Sbjct: 78 NCS--------------ATKSCVNTLGSYTCVCPEGFLLSSELGCEDVDECAEPGLSRCH 123
Query: 533 E-CSCKNTWGSYDCSCSGDLLYIRDHDTCISKTASQG 568
+C N G+Y C C L H C + G
Sbjct: 124 ALATCINGEGNYSCVCPAGYLGDGRHCECSPGSCGPG 160
>FBN2_MOUSE (Q61555) Fibrillin 2 precursor
Length = 2907
Score = 58.9 bits (141), Expect = 4e-08
Identities = 50/174 (28%), Positives = 72/174 (40%), Gaps = 29/174 (16%)
Query: 397 KAIC-SGFEETTEPAVCLSSDVETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVD 455
+ +C GF + + C ++ NEC N C + C++T +C C L
Sbjct: 1300 RCLCYDGFMASMDMKTC----IDVNECDLNPNICMFGE------CENTKGSFICHCQLGY 1349
Query: 456 GVQFKGDGYTTCEASGPGRCKIKNGGCWHEARNGHAFSACVD-DGEVKCQCPAGFKGDGV 514
V+ G T + C+I A N ++C++ G KC C G+ G+G+
Sbjct: 1350 SVKKGTTGCTDVD-----ECEIG-------AHNCDMHASCLNVPGSFKCSCREGWVGNGI 1397
Query: 515 KNCQDVDECKEKKACQCPECSCKNTWGSYDCSCS----GDLLYIRDHDTCISKT 564
K C D+DEC C NT GSY C+CS GD D D C T
Sbjct: 1398 K-CIDLDECANGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTCSDVDECAENT 1450
Score = 56.6 bits (135), Expect = 2e-07
Identities = 40/132 (30%), Positives = 58/132 (43%), Gaps = 25/132 (18%)
Query: 418 ETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGYTTCEASGPGRCKI 477
+ NECLE+ G C + N +FR CECP+ + YT C I
Sbjct: 2164 DVNECLESPGICSNGQCINTDG---SFR---CECPMGYNLD-----YTGVRCVDTDECSI 2212
Query: 478 KNGGCWHEARNGHAFSACVDDGEVKCQCPAGFKGDGVKNCQDVDECKEKKACQCPECS-- 535
N NG + G +C C GF+ + NC+D++EC + C+
Sbjct: 2213 GN-----PCGNGTCTNVI---GCFECTCNEGFEPGPMMNCEDINECAQNPLL----CAFR 2260
Query: 536 CKNTWGSYDCSC 547
C NT+GSY+C+C
Sbjct: 2261 CMNTFGSYECTC 2272
Score = 54.3 bits (129), Expect = 1e-06
Identities = 44/124 (35%), Positives = 53/124 (42%), Gaps = 21/124 (16%)
Query: 446 GRVCE-CPLVDGVQFK-----GDGYTTCEASGPGRCKIKNGGCWHEARNGHAFSACVDD- 498
G CE CPL Q+K G GY T + CK+ C NG CV+
Sbjct: 2412 GHQCELCPLPGTAQYKKICPHGPGYAT-DGRDIDECKVMPSLC----TNGQ----CVNTM 2462
Query: 499 GEVKCQCPAGFKGD-GVKNCQDVDECKEK-KACQCPECSCKNTWGSYDCSCSGDLLYIRD 556
G +C C G+ D C D+DEC + K C CKNT GSY CSC + D
Sbjct: 2463 GSFRCFCKVGYTMDISGTACVDLDECSQSPKPCNF---ICKNTKGSYQCSCPRGYVLQED 2519
Query: 557 HDTC 560
TC
Sbjct: 2520 GKTC 2523
Score = 52.8 bits (125), Expect = 3e-06
Identities = 41/147 (27%), Positives = 55/147 (36%), Gaps = 23/147 (15%)
Query: 417 VETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGYTTCEASGPGRCK 476
V+ NEC ++ C K N+ +C G Q D + C
Sbjct: 1192 VDINECSLSDNLCRNGKCVNMIG--------TYQCSCNPGYQATPDRQGCTDID---ECM 1240
Query: 477 IKNGGCWHEARNGHAFSACVDDGEVKCQCPAGFK--GDGVKNCQDVDECKEKKACQCPEC 534
I NGGC + N +G +C C G+ DG ++C D+DEC E C
Sbjct: 1241 IMNGGCDTQCTNS--------EGSYECSCSEGYALMPDG-RSCADIDEC-ENNPDICDGG 1290
Query: 535 SCKNTWGSYDCSCSGDLLYIRDHDTCI 561
C N G Y C C + D TCI
Sbjct: 1291 QCTNIPGEYRCLCYDGFMASMDMKTCI 1317
Score = 50.4 bits (119), Expect = 1e-05
Identities = 59/251 (23%), Positives = 98/251 (38%), Gaps = 30/251 (11%)
Query: 315 CPMKEK-KYNKKCADAVIESLGLDNKKIERCMGDPD--ADSDNPVLKEEQDAQVGKGSRG 371
CP K +++ C+ + + +D + I C DPD A+ L+ G
Sbjct: 737 CPAKNSAEFHGLCSSGI--GITVDGRDINECALDPDICANGICENLRGTYRCNCNSGYEP 794
Query: 372 DVTILPTLVVNNRQYRGKLEKGAVMKAICSGFEETTEPAVCLSSDVET----NECLEN-- 425
D + + ++ L + + + T P L ++ ET NEC N
Sbjct: 795 DASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVLPTETETCEDVNECESNPC 854
Query: 426 -NGGCWKDKAANITAC----KDTFRGRVCECPLVDGVQFKGDGYTTCEASGPGRCKIKNG 480
NG C + + C K + G +C +D + KG + + + RC++
Sbjct: 855 VNGACRNNLGSFHCECSPGSKLSSTGLIC----IDSL--KGTCWLNIQDN---RCEVNIN 905
Query: 481 GCWHE----ARNGHAFSACVDDGEVKCQCPAGFKGDGVKNCQDVDECKEKKACQCPECSC 536
G + A G A+ + + E+ CP GF C+DV+EC E CP C
Sbjct: 906 GATLKSECCATLGGAWGSPCERCELDAACPRGFARIKGVTCEDVNEC-EVFPGVCPNGRC 964
Query: 537 KNTWGSYDCSC 547
N+ GS+ C C
Sbjct: 965 VNSKGSFHCEC 975
Score = 50.4 bits (119), Expect = 1e-05
Identities = 25/68 (36%), Positives = 33/68 (47%), Gaps = 2/68 (2%)
Query: 499 GEVKCQCPAGFK-GDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDH 557
G +C+CPAG K + + C+D+DEC C C NT GSY C C + D
Sbjct: 297 GSFECRCPAGHKQSETTQKCEDIDECSVIPGV-CETGDCSNTVGSYFCLCPRGFVTSTDG 355
Query: 558 DTCISKTA 565
CI + A
Sbjct: 356 SRCIDQRA 363
Score = 50.4 bits (119), Expect = 1e-05
Identities = 48/201 (23%), Positives = 73/201 (35%), Gaps = 46/201 (22%)
Query: 400 CSGFEETTEPAVCLSSDVETNECLENNGG----CWKDKAANITA--CKDTFRGRVCECPL 453
C+ +E P +C++ C+ N G C A + C DT C +
Sbjct: 649 CTDVDECQTPGICMNG-----HCINNEGSFRCDCPPGLAVGVDGRVCVDTHMRSTCYGEI 703
Query: 454 VDGVQFKG-DGYTT---CEASGPGR--------CKIKNGGCWHE--------ARNGHAFS 493
GV + G T C + P C KN +H +G +
Sbjct: 704 KKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGIGITVDGRDIN 763
Query: 494 ACVDD-------------GEVKCQCPAGFKGDGV-KNCQDVDECKEKKACQCPECSCKNT 539
C D G +C C +G++ D +NC D+DEC + C C+NT
Sbjct: 764 ECALDPDICANGICENLRGTYRCNCNSGYEPDASGRNCIDIDECLVNRLL-CDNGLCRNT 822
Query: 540 WGSYDCSCSGDLLYIRDHDTC 560
GSY C+C + + +TC
Sbjct: 823 PGSYSCTCPPGYVLPTETETC 843
Score = 49.3 bits (116), Expect = 3e-05
Identities = 36/115 (31%), Positives = 47/115 (40%), Gaps = 28/115 (24%)
Query: 440 CKDTFRGRVCECPLVDGVQFKGDGYTTC----EASGPGRCKIKNGGCWHEARNGHAFSAC 495
C++ G C CP D ++ + C E S PG C + C++
Sbjct: 2621 CQNILGGYRCGCPHGDVQHYQ---WNQCVDENECSNPGACG--SASCYNTL--------- 2666
Query: 496 VDDGEVKCQCPAGFKGDGVKN-CQDVDECKEKKACQCPECS--CKNTWGSYDCSC 547
G KC CP+GF D + C DV+EC K CS C NT G Y C C
Sbjct: 2667 ---GSYKCACPSGFSFDQFSSACHDVNECSSSKN----PCSYGCSNTEGGYLCGC 2714
Score = 46.2 bits (108), Expect = 3e-04
Identities = 43/165 (26%), Positives = 57/165 (34%), Gaps = 32/165 (19%)
Query: 401 SGFEETTEPAVCLSSDVETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFK 460
+GF+ T C+ D EC++N C + N +C G +
Sbjct: 555 AGFQRTPTKQACIDID----ECIQNGVLCKNGRCVNSDGS--------FQCICNAGFELT 602
Query: 461 GDGYTTC---EASGPGRCKIKNGGCWHEARNGHAFSACVDDGEVKCQCPAGF-KGDGVKN 516
DG E + C NG C +E DG KC C GF +
Sbjct: 603 TDGKNCVDHDECTTTNMCL--NGMCINE------------DGSFKCVCKPGFILAPNGRY 648
Query: 517 CQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDHDTCI 561
C DVDEC+ C C N GS+ C C L D C+
Sbjct: 649 CTDVDECQTPGICMNGHCI--NNEGSFRCDCPPGLAVGVDGRVCV 691
Score = 45.4 bits (106), Expect = 4e-04
Identities = 43/154 (27%), Positives = 61/154 (38%), Gaps = 29/154 (18%)
Query: 416 DVETNECLENNGG--CWKDKAANITA--CKDTFR-----GRVCE-CPLVDGVQFKG---- 461
D+ + C + G C + N+T C T+ + CE CP FK
Sbjct: 1727 DMRKSFCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAGNKPCEPCPTPGTADFKTICGN 1786
Query: 462 -DGYT----TCEASGPGRCKIKNGGCWHEARNGHAFSACVDD-GEVKCQCPAGFK-GDGV 514
G+T T +A CK G C A C++ G +C+CP GF D +
Sbjct: 1787 IPGFTFDIHTGKAVDIDECKEIPGIC--------ANGVCINQIGSFRCECPTGFSYNDLL 1838
Query: 515 KNCQDVDECKEKKACQCPECSCKNTWGSYDCSCS 548
C+D+DEC C N+ GSY C C+
Sbjct: 1839 LVCEDIDECSNGDNLCQRNADCINSPGSYRCECA 1872
Score = 45.1 bits (105), Expect = 6e-04
Identities = 20/69 (28%), Positives = 33/69 (46%), Gaps = 2/69 (2%)
Query: 499 GEVKCQCPAGFK-GDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDH 557
G +C+CP G+ + + C+D+DEC C +C NT G+Y C C + + +
Sbjct: 1664 GSFQCECPQGYYLSEETRICEDIDECFAHPGV-CGPGTCYNTLGNYTCICPPEYMQVNGG 1722
Query: 558 DTCISKTAS 566
C+ S
Sbjct: 1723 HNCMDMRKS 1731
Score = 45.1 bits (105), Expect = 6e-04
Identities = 22/60 (36%), Positives = 26/60 (42%), Gaps = 3/60 (5%)
Query: 502 KCQCPAGFKGDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDHDTCI 561
+C+C G+K D +C DVDEC C C NT GSY C C CI
Sbjct: 511 RCRCNMGYKQDANGDCIDVDECTSN---PCSNGDCVNTPGSYYCKCHAGFQRTPTKQACI 567
Score = 45.1 bits (105), Expect = 6e-04
Identities = 43/161 (26%), Positives = 54/161 (32%), Gaps = 54/161 (33%)
Query: 440 CKDTFRGRVCECPLVDGVQFKGDGYTTCEASGPGRCKIKNGGCWHEARNGHAFSACVDD- 498
C +T G C+CP G+T + C I N C + A C +
Sbjct: 2540 CVNTLGGFTCKCP---------PGFTQHHTA----C-IDNNECGSQPSLCGAKGICQNTP 2585
Query: 499 GEVKCQCPAGFKGDGVK-NCQDVDECKEKKACQ-------------CP------------ 532
G C+C GF D NC+DVDEC CQ CP
Sbjct: 2586 GSFSCECQRGFSLDASGLNCEDVDECDGNHRCQHGCQNILGGYRCGCPHGDVQHYQWNQC 2645
Query: 533 ----ECS---------CKNTWGSYDCSCSGDLLYIRDHDTC 560
ECS C NT GSY C+C + + C
Sbjct: 2646 VDENECSNPGACGSASCYNTLGSYKCACPSGFSFDQFSSAC 2686
Score = 44.7 bits (104), Expect = 8e-04
Identities = 42/150 (28%), Positives = 58/150 (38%), Gaps = 28/150 (18%)
Query: 417 VETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGYTTCE-----ASG 471
V+ +EC E G C N +FR CECP G + D CE ++G
Sbjct: 1800 VDIDECKEIPGICANGVCINQIG---SFR---CECPT--GFSYN-DLLLVCEDIDECSNG 1850
Query: 472 PGRCKIKNGGCWHEARNGHAFSACVDDGEVKCQCPAGFKGDGVKNCQDVDECKEKKACQC 531
C+ +N C + G +C+C AGFK C D +EC E C
Sbjct: 1851 DNLCQ-RNADCINSP------------GSYRCECAAGFKLSPNGACVDRNECLEIPNV-C 1896
Query: 532 PECSCKNTWGSYDCSCSGDLLYIRDHDTCI 561
C + GSY C C+ +D C+
Sbjct: 1897 SHGLCVDLQGSYQCICNNGFKASQDQTMCM 1926
Score = 44.3 bits (103), Expect = 0.001
Identities = 39/162 (24%), Positives = 63/162 (38%), Gaps = 21/162 (12%)
Query: 400 CSGFEETTEPAVCLSSDVETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQF 459
C FE + + + ++ +EC N C C +T C+CPL +
Sbjct: 1133 CECFEGYESGFMMMKNCMDIDECERNPLLCRGG------TCVNTEGSFQCDCPLGHELSP 1186
Query: 460 KGDGYTTCEASGPGRCKIKNGGCWHEARNGHAFSACVDDGEVKCQCPAGFKGDGVKN-CQ 518
+ + C + + C RNG + G +C C G++ + C
Sbjct: 1187 SRE-----DCVDINECSLSDNLC----RNGKCVNMI---GTYQCSCNPGYQATPDRQGCT 1234
Query: 519 DVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDHDTC 560
D+DEC C + C N+ GSY+CSCS + D +C
Sbjct: 1235 DIDECMIMNG-GC-DTQCTNSEGSYECSCSEGYALMPDGRSC 1274
Score = 43.9 bits (102), Expect = 0.001
Identities = 42/154 (27%), Positives = 61/154 (39%), Gaps = 29/154 (18%)
Query: 397 KAICS-GFEETTEPAVCLSSDVETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVD 455
+ IC+ GF+ + + +C+ D C + AN T CK+T C C
Sbjct: 1909 QCICNNGFKASQDQTMCMDVDE-----------CERHPCANGT-CKNTVGSYNCLCYPGF 1956
Query: 456 GVQFKGDGYTTCEASGPGRCKIKNGGCWHEARNGHAFSACVDDGEVKCQCPAGFK--GDG 513
+ D E S +NG C++E G KC C G++ DG
Sbjct: 1957 ELTHNNDCLDIDECSSFFGQVCRNGRCFNEI------------GSFKCLCNEGYELTPDG 2004
Query: 514 VKNCQDVDECKEKKACQCPECSCKNTWGSYDCSC 547
KNC D +EC C +C+N GS+ C C
Sbjct: 2005 -KNCIDTNECVALPG-SCSPGTCQNLEGSFRCIC 2036
Score = 43.5 bits (101), Expect = 0.002
Identities = 34/102 (33%), Positives = 44/102 (42%), Gaps = 16/102 (15%)
Query: 451 CPLVDGVQFKGD---GYTTCEASGPGRCKIKNGGCWH-EARNGHAFSACVDDGEVKCQCP 506
CP G +GD G C+ CK G C + + RN G KC+C
Sbjct: 1045 CPRGPGFANRGDILTGRPFCKDIN--ECKAFPGMCTYGKCRN--------TIGSFKCRCN 1094
Query: 507 AGFKGD-GVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSC 547
GF D +NC D+DEC+ C C NT GS++C C
Sbjct: 1095 NGFALDMEERNCTDIDECRISPDL-CGSGICVNTPGSFECEC 1135
Score = 43.1 bits (100), Expect = 0.002
Identities = 49/161 (30%), Positives = 68/161 (41%), Gaps = 26/161 (16%)
Query: 400 CSGFEETTEPAVCLSS-DVETNECLENNGGCWKDKAANITA--CKDTFRGRVCECPLVDG 456
C+ +E +P C++ V T E N C D N T C D RV C L G
Sbjct: 1523 CTDIDECADPINCVNGLCVNTPGRYECN--CPPDFQLNATGVGCVDN---RVGNCYLKFG 1577
Query: 457 VQFKGDGYTTCEA-SGPG----RCKIKNGGCWHEARNGHAFSAC--VDDGEVKCQCPAG- 508
+GDG +C +G G C G W G+ C V+ E CP G
Sbjct: 1578 P--RGDGSLSCNTEAGVGVSRSSCCCSLGKAW-----GNPCETCPPVNSTEHYTLCPGGE 1630
Query: 509 -FKGDGVKNC-QDVDECKEKKACQCPECSCKNTWGSYDCSC 547
F+ + + +D+DEC+E C +C NT+GS+ C C
Sbjct: 1631 GFRPNPITIILEDIDECQELPGL-CQGGNCINTFGSFQCEC 1670
Score = 43.1 bits (100), Expect = 0.002
Identities = 38/135 (28%), Positives = 56/135 (41%), Gaps = 24/135 (17%)
Query: 418 ETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGYTTCEASGPGRCKI 477
+ +EC EN C + N+ +R CEC + G+T AS C+
Sbjct: 1442 DVDECAENTNLCENGQCLNVPGA---YR---CECEM---------GFTP--ASDSRSCQD 1484
Query: 478 KNGGCWHEARNGHAFSACVD-DGEVKCQCPAGFKGDGVK-NCQDVDECKEKKACQCPECS 535
+ + +N F C + G C C G++ D NC D+DEC + C
Sbjct: 1485 IDECSF---QNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECADP--INCVNGL 1539
Query: 536 CKNTWGSYDCSCSGD 550
C NT G Y+C+C D
Sbjct: 1540 CVNTPGRYECNCPPD 1554
Score = 43.1 bits (100), Expect = 0.002
Identities = 36/133 (27%), Positives = 53/133 (39%), Gaps = 24/133 (18%)
Query: 417 VETNECLENNGGCWKDKAANITA-CKDTFRGRVCECPLVDGVQFKGDGYTTCEASGPGRC 475
++ +EC C +I A C +T C C +G F GDG+T + C
Sbjct: 1400 IDLDECANGTHQC------SINAQCVNTPGSYRCACS--EG--FTGDGFTCSDVD---EC 1446
Query: 476 KIKNGGCWHEARNGHAFSACVDDGEVKCQCPAGFK-GDGVKNCQDVDECKEKKACQCPEC 534
C NG + G +C+C GF ++CQD+DEC + C
Sbjct: 1447 AENTNLC----ENGQCLNV---PGAYRCECEMGFTPASDSRSCQDIDECSFQNICVFG-- 1497
Query: 535 SCKNTWGSYDCSC 547
+C N G + C C
Sbjct: 1498 TCNNLPGMFHCIC 1510
Score = 42.7 bits (99), Expect = 0.003
Identities = 44/168 (26%), Positives = 61/168 (36%), Gaps = 34/168 (20%)
Query: 418 ETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGYTT----------- 466
+ NEC G C + N K +F CECP +G+ G G
Sbjct: 948 DVNECEVFPGVCPNGRCVN---SKGSFH---CECP--EGLTLDGTGRVCLDIRMEHCFLK 999
Query: 467 -----CEASGPGRCKIKNGGCWHEARNGHAFSACVDDG--EVKCQCPAG----FKGD--- 512
C PG+ ++ C A G C G E + CP G +GD
Sbjct: 1000 WDEDECIHPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPRGPGFANRGDILT 1059
Query: 513 GVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDHDTC 560
G C+D++ECK C C+NT GS+ C C+ + C
Sbjct: 1060 GRPFCKDINECKAFPG-MCTYGKCRNTIGSFKCRCNNGFALDMEERNC 1106
Score = 42.0 bits (97), Expect = 0.005
Identities = 23/69 (33%), Positives = 32/69 (46%), Gaps = 3/69 (4%)
Query: 495 CVDD-GEVKCQCPAGFKGDGVKN-CQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLL 552
CV+ G C+C AGF+ K C D+DEC + C C N+ GS+ C C+
Sbjct: 542 CVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVL-CKNGRCVNSDGSFQCICNAGFE 600
Query: 553 YIRDHDTCI 561
D C+
Sbjct: 601 LTTDGKNCV 609
Score = 41.6 bits (96), Expect = 0.006
Identities = 37/145 (25%), Positives = 48/145 (32%), Gaps = 20/145 (13%)
Query: 417 VETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGYTTCEASGPGRCK 476
V+ NECLE C + C D C C +G + D + R
Sbjct: 1884 VDRNECLEIPNVC------SHGLCVDLQGSYQCICN--NGFKASQDQTMCMDVDECERHP 1935
Query: 477 IKNGGCWHEARNGHAFSACVDDGEVKCQCPAGFKGDGVKNCQDVDECKEKKACQCPECSC 536
NG C + G C C GF+ +C D+DEC C C
Sbjct: 1936 CANGTCKNTV------------GSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGRC 1983
Query: 537 KNTWGSYDCSCSGDLLYIRDHDTCI 561
N GS+ C C+ D CI
Sbjct: 1984 FNEIGSFKCLCNEGYELTPDGKNCI 2008
Score = 41.6 bits (96), Expect = 0.006
Identities = 40/151 (26%), Positives = 59/151 (38%), Gaps = 32/151 (21%)
Query: 405 ETTEPAVCLSSDVETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGY 464
E EP ++ + + NEC +N C C +TF C CP+ G++ +
Sbjct: 2234 EGFEPGPMMNCE-DINECAQNPLLC-------AFRCMNTFGSYECTCPVGYGLR---EDQ 2282
Query: 465 TTCE-----ASGPGRCKIKNGGCWHEARNGHAFSACVDDGEVKCQCPAGF--KGDGVKNC 517
C+ A G C+ + C + G C CP G + DG + C
Sbjct: 2283 KMCKDLDECAEGLHDCESRGMMCKNLI------------GTFMCICPPGMARRPDG-EGC 2329
Query: 518 QDVDECKEKKACQCPECSCKNTWGSYDCSCS 548
D +EC+ K C C N GSY C C+
Sbjct: 2330 VDENECRTKPGI-CENGRCVNIIGSYRCECN 2359
Score = 41.2 bits (95), Expect = 0.008
Identities = 18/51 (35%), Positives = 26/51 (50%), Gaps = 4/51 (7%)
Query: 499 GEVKCQCPAGFK-GDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSCS 548
G C CP G+ + C+DV+EC+ C +C+N GS+ C CS
Sbjct: 824 GSYSCTCPPGYVLPTETETCEDVNECESNP---CVNGACRNNLGSFHCECS 871
Score = 38.5 bits (88), Expect = 0.054
Identities = 40/130 (30%), Positives = 48/130 (36%), Gaps = 10/130 (7%)
Query: 420 NECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGYTTCEASGPGRCKIKN 479
N C +N G C N AC F G CE G F C+ G K
Sbjct: 182 NGC-QNGGRCI---GPNRCACVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLTGIVCTKT 237
Query: 480 GGCWHEARN-GHAFSACVDDGEVKCQCPAGFKGD-GVKNCQDVDECKEKKACQCPECSCK 537
C R GH C + C GF + CQDVDEC+ C +C
Sbjct: 238 LCCATIGRAWGHPCEMCPAQPQ---PCRPGFIPNIRTGACQDVDECQAIPGL-CQGGNCI 293
Query: 538 NTWGSYDCSC 547
NT GS++C C
Sbjct: 294 NTVGSFECRC 303
Score = 36.2 bits (82), Expect = 0.27
Identities = 50/202 (24%), Positives = 72/202 (34%), Gaps = 54/202 (26%)
Query: 397 KAICS-GFEETTEPAVCLSSD--VETNECLENNGGCWKDKAANITACKDTF----RGRVC 449
+ IC+ GFE TT+ C+ D TN CL NG C + + CK F GR C
Sbjct: 592 QCICNAGFELTTDGKNCVDHDECTTTNMCL--NGMCINEDGSFKCVCKPGFILAPNGRYC 649
Query: 450 ----ECPL----VDGVQFKGDGYTTCEASGPGRCKIKNGG----------CWHEARNG-- 489
EC ++G +G C+ PG +G C+ E + G
Sbjct: 650 TDVDECQTPGICMNGHCINNEGSFRCDCP-PGLAVGVDGRVCVDTHMRSTCYGEIKKGVC 708
Query: 490 -HAFSACVDDGEVKCQCPAGFKGDGVKNC----------------------QDVDECKEK 526
F V E C P G+ + C +D++EC
Sbjct: 709 VRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGIGITVDGRDINECALD 768
Query: 527 KACQCPECSCKNTWGSYDCSCS 548
C C+N G+Y C+C+
Sbjct: 769 PDI-CANGICENLRGTYRCNCN 789
>FBN2_HUMAN (P35556) Fibrillin 2 precursor
Length = 2911
Score = 58.9 bits (141), Expect = 4e-08
Identities = 42/143 (29%), Positives = 59/143 (40%), Gaps = 21/143 (14%)
Query: 418 ETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGYTTCEASGPGRCKI 477
+ NECLE+ G C + N +FR CECP+ + YT C I
Sbjct: 2170 DVNECLESPGICSNGQCINTDG---SFR---CECPMGYNLD-----YTGVRCVDTDECSI 2218
Query: 478 KNGGCWHEARNGHAFSACVDDGEVKCQCPAGFKGDGVKNCQDVDECKEKKACQCPECSCK 537
N NG + G +C C GF+ + NC+D++EC + C C
Sbjct: 2219 GN-----PCGNGTCTNVI---GSFECNCNEGFEPGPMMNCEDINECAQNPLL-C-ALRCM 2268
Query: 538 NTWGSYDCSCSGDLLYIRDHDTC 560
NT+GSY+C+C D C
Sbjct: 2269 NTFGSYECTCPIGYALREDQKMC 2291
Score = 58.5 bits (140), Expect = 5e-08
Identities = 49/170 (28%), Positives = 72/170 (41%), Gaps = 29/170 (17%)
Query: 397 KAIC-SGFEETTEPAVCLSSDVETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVD 455
+ +C GF + + C ++ NEC N+ C + C++T +C C L
Sbjct: 1306 RCLCYDGFMASMDMKTC----IDVNECDLNSNICMFGE------CENTKGSFICHCQLGY 1355
Query: 456 GVQFKGDGYTTCEASGPGRCKIKNGGCWHEARNGHAFSACVD-DGEVKCQCPAGFKGDGV 514
V+ G T + C+I A N ++C++ G KC C G+ G+G+
Sbjct: 1356 SVKKGTTGCTDVD-----ECEIG-------AHNCDMHASCLNIPGSFKCSCREGWIGNGI 1403
Query: 515 KNCQDVDECKEKKACQCPECSCKNTWGSYDCSCS----GDLLYIRDHDTC 560
K C D+DEC C NT GSY C+CS GD D D C
Sbjct: 1404 K-CIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTCSDVDEC 1452
Score = 58.2 bits (139), Expect = 7e-08
Identities = 51/165 (30%), Positives = 65/165 (38%), Gaps = 36/165 (21%)
Query: 421 ECLENNGG-CWKDKAANITACKDTFR----------------GRVCE-CPLVDGVQFK-- 460
ECL+N G C+ + I + R G CE CPL Q+K
Sbjct: 2376 ECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKI 2435
Query: 461 ---GDGYTTCEASGPGRCKIKNGGCWHEARNGHAFSACVDDGEVKCQCPAGFKGD-GVKN 516
G GYTT + CK+ C NG + G +C C G+ D +
Sbjct: 2436 CPHGPGYTT-DGRDIDECKVMPNLC----TNGQCINTM---GSFRCFCKVGYTTDISGTS 2487
Query: 517 CQDVDECKEK-KACQCPECSCKNTWGSYDCSCSGDLLYIRDHDTC 560
C D+DEC + K C CKNT GSY CSC + D TC
Sbjct: 2488 CIDLDECSQSPKPCNY---ICKNTEGSYQCSCPRGYVLQEDGKTC 2529
Score = 52.8 bits (125), Expect = 3e-06
Identities = 41/147 (27%), Positives = 55/147 (36%), Gaps = 23/147 (15%)
Query: 417 VETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGYTTCEASGPGRCK 476
V+ NEC ++ C K N+ +C G Q D + C
Sbjct: 1198 VDINECSLSDNLCRNGKCVNMIG--------TYQCSCNPGYQATPDRQGCTDID---ECM 1246
Query: 477 IKNGGCWHEARNGHAFSACVDDGEVKCQCPAGFK--GDGVKNCQDVDECKEKKACQCPEC 534
I NGGC + N +G +C C G+ DG ++C D+DEC E C
Sbjct: 1247 IMNGGCDTQCTNS--------EGSYECSCSEGYALMPDG-RSCADIDEC-ENNPDICDGG 1296
Query: 535 SCKNTWGSYDCSCSGDLLYIRDHDTCI 561
C N G Y C C + D TCI
Sbjct: 1297 QCTNIPGEYRCLCYDGFMASMDMKTCI 1323
Score = 50.8 bits (120), Expect = 1e-05
Identities = 45/204 (22%), Positives = 71/204 (34%), Gaps = 52/204 (25%)
Query: 400 CSGFEETTEPAVCLSSDVETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQF 459
C+ +E P +C++ C+ + G D + D GRVC + +
Sbjct: 655 CTDVDECQTPGICMNG-----HCINSEGSFRCDCPPGLAVGMD---GRVCVDTHMRSTCY 706
Query: 460 KGDGYTTCEASGPGR---------------------CKIKNGGCWHE--------ARNGH 490
G C PG C KN +H +G
Sbjct: 707 GGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGITVDGR 766
Query: 491 AFSACVDD-------------GEVKCQCPAGFKGDGV-KNCQDVDECKEKKACQCPECSC 536
+ C D G +C C +G++ D +NC D+DEC + C C
Sbjct: 767 DINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLL-CDNGLC 825
Query: 537 KNTWGSYDCSCSGDLLYIRDHDTC 560
+NT GSY C+C ++ + +TC
Sbjct: 826 RNTPGSYSCTCPPGYVFRTETETC 849
Score = 48.9 bits (115), Expect = 4e-05
Identities = 26/67 (38%), Positives = 35/67 (51%), Gaps = 4/67 (5%)
Query: 499 GEVKCQCPAGFK-GDGVKNCQDVDECKEKKA-CQCPECSCKNTWGSYDCSCSGDLLYIRD 556
G +C+CPAG K + + C+D+DEC C+ ECS NT GSY C C + D
Sbjct: 296 GSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGECS--NTVGSYFCVCPRGYVTSTD 353
Query: 557 HDTCISK 563
CI +
Sbjct: 354 GSRCIDQ 360
Score = 48.1 bits (113), Expect = 7e-05
Identities = 59/251 (23%), Positives = 96/251 (37%), Gaps = 30/251 (11%)
Query: 315 CPMKEK-KYNKKCADAVIESLGLDNKKIERCMGDPD--ADSDNPVLKEEQDAQVGKGSRG 371
CP K +++ C+ V + +D + I C DPD A+ L+ G
Sbjct: 743 CPAKNSAEFHGLCSSGV--GITVDGRDINECALDPDICANGICENLRGSYRCNCNSGYEP 800
Query: 372 DVTILPTLVVNNRQYRGKLEKGAVMKAICSGFEETTEPAVCLSSDVET----NECLEN-- 425
D + + ++ L + + + T P ++ ET NEC N
Sbjct: 801 DASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINECESNPC 860
Query: 426 -NGGCWKDKAANITAC----KDTFRGRVCECPLVDGVQFKGDGYTTCEASGPGRCKIKNG 480
NG C + + C K + G +C +D + KG + + S RC++
Sbjct: 861 VNGACRNNLGSFNCECSPGSKLSSTGLIC----IDSL--KGTCWLNIQDS---RCEVNIN 911
Query: 481 GCWHE----ARNGHAFSACVDDGEVKCQCPAGFKGDGVKNCQDVDECKEKKACQCPECSC 536
G + A G A+ + + E+ CP G C+DV+EC E CP C
Sbjct: 912 GATLKSECCATLGAAWGSPCERCELDTACPRGLARIKGVTCEDVNEC-EVFPGVCPNGRC 970
Query: 537 KNTWGSYDCSC 547
N+ GS+ C C
Sbjct: 971 VNSKGSFHCEC 981
Score = 47.0 bits (110), Expect = 2e-04
Identities = 43/165 (26%), Positives = 58/165 (35%), Gaps = 32/165 (19%)
Query: 401 SGFEETTEPAVCLSSDVETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFK 460
+GF+ T C+ D EC++N C + N +C G +
Sbjct: 561 AGFQRTPTKQACIDID----ECIQNGVLCKNGRCVNSDGS--------FQCICNAGFELT 608
Query: 461 GDGYTTC---EASGPGRCKIKNGGCWHEARNGHAFSACVDDGEVKCQCPAGFK-GDGVKN 516
DG E + C NG C +E DG KC C GF +
Sbjct: 609 TDGKNCVDHDECTTTNMCL--NGMCINE------------DGSFKCICKPGFVLAPNGRY 654
Query: 517 CQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDHDTCI 561
C DVDEC+ C C N+ GS+ C C L D C+
Sbjct: 655 CTDVDECQTPGICMNGHCI--NSEGSFRCDCPPGLAVGMDGRVCV 697
Score = 45.4 bits (106), Expect = 4e-04
Identities = 64/295 (21%), Positives = 98/295 (32%), Gaps = 94/295 (31%)
Query: 414 SSDVETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGYTTCEASGPG 473
++D+ C++ + K N CK+T C CP G + DG T +
Sbjct: 2480 TTDISGTSCIDLDECSQSPKPCNYI-CKNTEGSYQCSCPR--GYVLQEDGKTCKDLD--- 2533
Query: 474 RCKIKNGGCWHEARNG-------------HAFSACVDD--------------------GE 500
C+ K C N +AC+D+ G
Sbjct: 2534 ECQTKQHNCQFLCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQPLLCGGKGICQNTPGS 2593
Query: 501 VKCQCPAGFKGDGVK-NCQDVDECKEKKACQ-------------CP-------------- 532
C+C GF D NC+DVDEC CQ CP
Sbjct: 2594 FSCECQRGFSLDATGLNCEDVDECDGNHRCQHGCQNILGGYRCGCPQGYIQHYQWNQCVD 2653
Query: 533 --ECS---------CKNTWGSYDCSCSGDLLYIRDHDTC--ISKTASQGGRSAWAAFWVI 579
ECS C NT GSY C+C + + C +++ +S +
Sbjct: 2654 ENECSNPNACGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNECSSSKNPCNYGC---- 2709
Query: 580 IAGLVLSAGGGYLI----YKYRI-RSYMDSEIRAIMAQYMPLDSQAEVVNHVNDE 629
+ GGYL YR+ + + S + QY+ LD++ + N ++ E
Sbjct: 2710 -----SNTEGGYLCGCPPGYYRVGQGHCVSGMGFNKGQYLSLDTEVDEENALSPE 2759
Score = 45.4 bits (106), Expect = 4e-04
Identities = 43/154 (27%), Positives = 61/154 (38%), Gaps = 29/154 (18%)
Query: 416 DVETNECLENNGG--CWKDKAANITA--CKDTFR-----GRVCE-CPLVDGVQFKG---- 461
D+ + C + G C + N+T C T+ + CE CP FK
Sbjct: 1733 DMRKSFCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAGNKPCEPCPTPGTADFKTICGN 1792
Query: 462 -DGYT----TCEASGPGRCKIKNGGCWHEARNGHAFSACVDD-GEVKCQCPAGFK-GDGV 514
G+T T +A CK G C A C++ G +C+CP GF D +
Sbjct: 1793 IPGFTFDIHTGKAVDIDECKEIPGIC--------ANGVCINQIGSFRCECPTGFSYNDLL 1844
Query: 515 KNCQDVDECKEKKACQCPECSCKNTWGSYDCSCS 548
C+D+DEC C N+ GSY C C+
Sbjct: 1845 LVCEDIDECSNGDNLCQRNADCINSPGSYRCECA 1878
Score = 45.4 bits (106), Expect = 4e-04
Identities = 22/60 (36%), Positives = 26/60 (42%), Gaps = 3/60 (5%)
Query: 502 KCQCPAGFKGDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDHDTCI 561
+C+C G+K D +C DVDEC C C NT GSY C C CI
Sbjct: 517 RCECNMGYKQDANGDCIDVDECTSN---PCTNGDCVNTPGSYYCKCHAGFQRTPTKQACI 573
Score = 45.4 bits (106), Expect = 4e-04
Identities = 20/69 (28%), Positives = 33/69 (46%), Gaps = 2/69 (2%)
Query: 499 GEVKCQCPAGFK-GDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDH 557
G +C+CP G+ + + C+D+DEC C +C NT G+Y C C + + +
Sbjct: 1670 GSFQCECPQGYYLSEDTRICEDIDECFAHPGV-CGPGTCYNTLGNYTCICPPEYMQVNGG 1728
Query: 558 DTCISKTAS 566
C+ S
Sbjct: 1729 HNCMDMRKS 1737
Score = 44.7 bits (104), Expect = 8e-04
Identities = 35/133 (26%), Positives = 52/133 (38%), Gaps = 23/133 (17%)
Query: 418 ETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGYTTCEASGPGRCKI 477
+ NEC G C K C++T C C + + T + C+I
Sbjct: 1072 DINECKAFPGMCTYGK------CRNTIGSFKCRCNSGFALDMEERNCTDID-----ECRI 1120
Query: 478 KNGGCWHEARNGHAFSACVDD-GEVKCQCPAGFKGDGV--KNCQDVDECKEKKACQCPEC 534
C CV+ G +C+C G++ + KNC D+D C E+ C
Sbjct: 1121 SPDLC--------GSGICVNTPGSFECECFEGYESGFMMMKNCMDIDGC-ERNPLLCRGG 1171
Query: 535 SCKNTWGSYDCSC 547
+C NT GS+ C C
Sbjct: 1172 TCVNTEGSFQCDC 1184
Score = 44.3 bits (103), Expect = 0.001
Identities = 54/182 (29%), Positives = 73/182 (39%), Gaps = 32/182 (17%)
Query: 400 CSGFEETTEPAVCLSS-DVETNECLENNGGCWKDKAANITA--CKDTFRGRVCECPLVDG 456
C+ +E +P C++ V T E N C D N T C D RV C L G
Sbjct: 1529 CTDIDECADPINCVNGLCVNTPGRYECN--CPPDFQLNPTGVGCVDN---RVGNCYLKFG 1583
Query: 457 VQFKGDGYTTCEAS---GPGR--CKIKNGGCWHEARNGHAFSAC--VDDGEVKCQCPAG- 508
+GDG +C G R C G W G+ C V+ E CP G
Sbjct: 1584 P--RGDGSLSCNTEIGVGVSRSSCCCSLGKAW-----GNPCETCPPVNSTEYYTLCPGGE 1636
Query: 509 -FKGDGVKNC-QDVDECKEKKACQCPECSCKNTWGSYDCSC------SGDLLYIRDHDTC 560
F+ + + +D+DEC+E C +C NT+GS+ C C S D D D C
Sbjct: 1637 GFRPNPITIILEDIDECQELPGL-CQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDEC 1695
Query: 561 IS 562
+
Sbjct: 1696 FA 1697
Score = 43.9 bits (102), Expect = 0.001
Identities = 42/150 (28%), Positives = 57/150 (38%), Gaps = 28/150 (18%)
Query: 417 VETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGYTTCE-----ASG 471
V+ +EC E G C N +FR CECP G + D CE ++G
Sbjct: 1806 VDIDECKEIPGICANGVCINQIG---SFR---CECPT--GFSYN-DLLLVCEDIDECSNG 1856
Query: 472 PGRCKIKNGGCWHEARNGHAFSACVDDGEVKCQCPAGFKGDGVKNCQDVDECKEKKACQC 531
C+ +N C + G +C+C AGFK C D +EC E C
Sbjct: 1857 DNLCQ-RNADCINSP------------GSYRCECAAGFKLSPNGACVDRNECLEIPNV-C 1902
Query: 532 PECSCKNTWGSYDCSCSGDLLYIRDHDTCI 561
C + GSY C C +D C+
Sbjct: 1903 SHGLCVDLQGSYQCICHNGFKASQDQTMCM 1932
Score = 42.7 bits (99), Expect = 0.003
Identities = 32/122 (26%), Positives = 50/122 (40%), Gaps = 15/122 (12%)
Query: 440 CKDTFRGRVCECPLVDGVQFKGDGYTTCEASGPGRCKIKNGGCWHEARNGHAFSACVDDG 499
C +T C+CPL + + + C + + C RNG + G
Sbjct: 1173 CVNTEGSFQCDCPLGHELSPSRE-----DCVDINECSLSDNLC----RNGKCVNMI---G 1220
Query: 500 EVKCQCPAGFKGDGVKN-CQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDHD 558
+C C G++ + C D+DEC C + C N+ GSY+CSCS + D
Sbjct: 1221 TYQCSCNPGYQATPDRQGCTDIDECMIMNG-GC-DTQCTNSEGSYECSCSEGYALMPDGR 1278
Query: 559 TC 560
+C
Sbjct: 1279 SC 1280
Score = 42.4 bits (98), Expect = 0.004
Identities = 41/154 (26%), Positives = 60/154 (38%), Gaps = 29/154 (18%)
Query: 397 KAIC-SGFEETTEPAVCLSSDVETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVD 455
+ IC +GF+ + + +C+ D C + N T CK+T C C
Sbjct: 1915 QCICHNGFKASQDQTMCMDVDE-----------CERHPCGNGT-CKNTVGSYNCLCYPGF 1962
Query: 456 GVQFKGDGYTTCEASGPGRCKIKNGGCWHEARNGHAFSACVDDGEVKCQCPAGFK--GDG 513
+ D E S +NG C++E G KC C G++ DG
Sbjct: 1963 ELTHNNDCLDIDECSSFFGQVCRNGRCFNEI------------GSFKCLCNEGYELTPDG 2010
Query: 514 VKNCQDVDECKEKKACQCPECSCKNTWGSYDCSC 547
KNC D +EC C +C+N GS+ C C
Sbjct: 2011 -KNCIDTNECVALPG-SCSPGTCQNLEGSFRCIC 2042
Score = 42.0 bits (97), Expect = 0.005
Identities = 23/69 (33%), Positives = 32/69 (46%), Gaps = 3/69 (4%)
Query: 495 CVDD-GEVKCQCPAGFKGDGVKN-CQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLL 552
CV+ G C+C AGF+ K C D+DEC + C C N+ GS+ C C+
Sbjct: 548 CVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVL-CKNGRCVNSDGSFQCICNAGFE 606
Query: 553 YIRDHDTCI 561
D C+
Sbjct: 607 LTTDGKNCV 615
Score = 42.0 bits (97), Expect = 0.005
Identities = 36/133 (27%), Positives = 53/133 (39%), Gaps = 24/133 (18%)
Query: 417 VETNECLENNGGCWKDKAANITA-CKDTFRGRVCECPLVDGVQFKGDGYTTCEASGPGRC 475
++ +EC C +I A C +T C C +G F GDG+T + C
Sbjct: 1406 IDLDECSNGTHQC------SINAQCVNTPGSYRCACS--EG--FTGDGFTCSDVD---EC 1452
Query: 476 KIKNGGCWHEARNGHAFSACVDDGEVKCQCPAGFK-GDGVKNCQDVDECKEKKACQCPEC 534
C NG + G +C+C GF ++CQD+DEC + C
Sbjct: 1453 AENINLC----ENGQCLNV---PGAYRCECEMGFTPASDSRSCQDIDECSFQNI--CVSG 1503
Query: 535 SCKNTWGSYDCSC 547
+C N G + C C
Sbjct: 1504 TCNNLPGMFHCIC 1516
Score = 41.6 bits (96), Expect = 0.006
Identities = 17/51 (33%), Positives = 27/51 (52%), Gaps = 4/51 (7%)
Query: 499 GEVKCQCPAGFK-GDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSCS 548
G C CP G+ + C+D++EC+ C +C+N GS++C CS
Sbjct: 830 GSYSCTCPPGYVFRTETETCEDINECESNP---CVNGACRNNLGSFNCECS 877
Score = 41.2 bits (95), Expect = 0.008
Identities = 37/145 (25%), Positives = 48/145 (32%), Gaps = 20/145 (13%)
Query: 417 VETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGYTTCEASGPGRCK 476
V+ NECLE C + C D C C +G + D + R
Sbjct: 1890 VDRNECLEIPNVC------SHGLCVDLQGSYQCICH--NGFKASQDQTMCMDVDECERHP 1941
Query: 477 IKNGGCWHEARNGHAFSACVDDGEVKCQCPAGFKGDGVKNCQDVDECKEKKACQCPECSC 536
NG C + G C C GF+ +C D+DEC C C
Sbjct: 1942 CGNGTCKNTV------------GSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGRC 1989
Query: 537 KNTWGSYDCSCSGDLLYIRDHDTCI 561
N GS+ C C+ D CI
Sbjct: 1990 FNEIGSFKCLCNEGYELTPDGKNCI 2014
Score = 40.8 bits (94), Expect = 0.011
Identities = 41/151 (27%), Positives = 58/151 (38%), Gaps = 32/151 (21%)
Query: 405 ETTEPAVCLSSDVETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGY 464
E EP ++ + + NEC +N C C +TF C CP+ G + D
Sbjct: 2240 EGFEPGPMMNCE-DINECAQNPLLC-------ALRCMNTFGSYECTCPI--GYALRED-Q 2288
Query: 465 TTCE-----ASGPGRCKIKNGGCWHEARNGHAFSACVDDGEVKCQCPAGF--KGDGVKNC 517
C+ A G C+ + C + G C CP G + DG + C
Sbjct: 2289 KMCKDLDECAEGLHDCESRGMMCKNLI------------GTFMCICPPGMARRPDG-EGC 2335
Query: 518 QDVDECKEKKACQCPECSCKNTWGSYDCSCS 548
D +EC+ K C C N GSY C C+
Sbjct: 2336 VDENECRTKPGI-CENGRCVNIIGSYRCECN 2365
Score = 39.7 bits (91), Expect = 0.024
Identities = 20/53 (37%), Positives = 26/53 (48%), Gaps = 3/53 (5%)
Query: 499 GEVKCQCPAGFKGDGVK-NCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGD 550
G C C G++ D NC D+DEC + C C NT G Y+C+C D
Sbjct: 1510 GMFHCICDDGYELDRTGGNCTDIDECAD--PINCVNGLCVNTPGRYECNCPPD 1560
Score = 39.7 bits (91), Expect = 0.024
Identities = 45/168 (26%), Positives = 62/168 (36%), Gaps = 34/168 (20%)
Query: 418 ETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGYTT----------- 466
+ NEC G C + N K +F CECP +G+ G G
Sbjct: 954 DVNECEVFPGVCPNGRCVN---SKGSFH---CECP--EGLTLDGTGRVCLDIRMEQCYLK 1005
Query: 467 -----CEASGPGRCKIKNGGCWHEARNGHAFSACVDDG--EVKCQCP--AGF--KGD--- 512
C PG+ ++ C A G C G E + CP AGF +GD
Sbjct: 1006 WDEDECIHPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLT 1065
Query: 513 GVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDHDTC 560
G +D++ECK C C+NT GS+ C C+ + C
Sbjct: 1066 GRPFYKDINECKAFPG-MCTYGKCRNTIGSFKCRCNSGFALDMEERNC 1112
Score = 39.3 bits (90), Expect = 0.032
Identities = 40/130 (30%), Positives = 48/130 (36%), Gaps = 11/130 (8%)
Query: 420 NECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGYTTCEASGPGRCKIKN 479
N C +N G C A AC F G CE G F C+ G K
Sbjct: 182 NGC-QNGGRC----IAQPCACVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLTGIVCTKT 236
Query: 480 GGCWHEARN-GHAFSACVDDGEVKCQCPAGFKGD-GVKNCQDVDECKEKKACQCPECSCK 537
C R GH C + C GF + CQDVDEC+ C +C
Sbjct: 237 LCCATTGRAWGHPCEMCPAQPQ---PCRRGFIPNIRTGACQDVDECQAIPGI-CQGGNCI 292
Query: 538 NTWGSYDCSC 547
NT GS++C C
Sbjct: 293 NTVGSFECRC 302
Score = 35.0 bits (79), Expect = 0.60
Identities = 34/119 (28%), Positives = 44/119 (36%), Gaps = 37/119 (31%)
Query: 397 KAICS-GFEETTEPAVCLSSD--VETNECLENNGGCWKDKAANITACKDTF----RGRVC 449
+ IC+ GFE TT+ C+ D TN CL NG C + + CK F GR C
Sbjct: 598 QCICNAGFELTTDGKNCVDHDECTTTNMCL--NGMCINEDGSFKCICKPGFVLAPNGRYC 655
Query: 450 ECPLVDGVQFKGDGYTTCEASGPGRCKIKNGGCWHEARNGHAFSACVDDGEVKCQCPAG 508
E PG C NGH ++ +G +C CP G
Sbjct: 656 T--------------DVDECQTPGIC-----------MNGHCINS---EGSFRCDCPPG 686
>LTBS_HUMAN (P22064) Latent transforming growth factor beta binding
protein, isoform 1S precursor (LTBP-1) (Transforming
growth factor beta-1 binding protein 1) (TGF-beta1-BP-1)
Length = 1394
Score = 58.5 bits (140), Expect = 5e-08
Identities = 54/176 (30%), Positives = 81/176 (45%), Gaps = 26/176 (14%)
Query: 400 CSGFEETTEPAVCLSSDVETNECLENNGGCWKDKAANITA----CKDTF---RGRVC--- 449
C +E EP VC + D LE + C K T C+D +G +C
Sbjct: 709 CLDVDECLEPNVCANGDCSN---LEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNG 765
Query: 450 ECPLVDGVQFK---GDGYTTCEASGPGRCKIKNGGCWHEARNGHAFSACVD-DGEVKCQC 505
+C +G F+ G GY A +C+ + C H R+ A C + +G +C C
Sbjct: 766 QCKNTEG-SFRCTCGQGYQLSAAKD--QCEDIDE-CQH--RHLCAHGQCRNTEGSFQCVC 819
Query: 506 PAGFKGDGV-KNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDHDTC 560
G++ G+ +C+D++EC E K+ C C NT GSYDC+C D + D+ TC
Sbjct: 820 DQGYRASGLGDHCEDINECLEDKSV-CQRGDCINTAGSYDCTCP-DGFQLDDNKTC 873
Score = 55.1 bits (131), Expect = 6e-07
Identities = 28/72 (38%), Positives = 36/72 (49%), Gaps = 7/72 (9%)
Query: 499 GEVKCQCPAGFKGDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSC------SGDLL 552
G C CP GF+ D K CQD++EC+ C P+ C NT GS+ C C S D
Sbjct: 855 GSYDCTCPDGFQLDDNKTCQDINECEHPGLCG-PQGECLNTEGSFHCVCQQGFSISADGR 913
Query: 553 YIRDHDTCISKT 564
D D C++ T
Sbjct: 914 TCEDIDECVNNT 925
Score = 55.1 bits (131), Expect = 6e-07
Identities = 45/150 (30%), Positives = 56/150 (37%), Gaps = 31/150 (20%)
Query: 418 ETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGYTTC----EASGPG 473
+ NECLE+ C + N D C CP DG Q D TC E PG
Sbjct: 834 DINECLEDKSVCQRGDCINTAGSYD------CTCP--DGFQL--DDNKTCQDINECEHPG 883
Query: 474 RCKIKNGGCWHEARNGHAFSACVDDGEVKCQCPAGFK--GDGVKNCQDVDECKEKKACQC 531
C G C + +G C C GF DG + C+D+DEC C
Sbjct: 884 LCG-PQGECLNT------------EGSFHCVCQQGFSISADG-RTCEDIDECVNNTVCDS 929
Query: 532 PECSCKNTWGSYDCSCSGDLLYIRDHDTCI 561
C NT GS+ C C +D C+
Sbjct: 930 -HGFCDNTAGSFRCLCYQGFQAPQDGQGCV 958
Score = 48.9 bits (115), Expect = 4e-05
Identities = 48/167 (28%), Positives = 66/167 (38%), Gaps = 30/167 (17%)
Query: 413 LSSDVETNECLENNGGCWKDKAANITACKDTFRGRVCE-CPLVDGVQFKGDGYTTCEASG 471
L+ +V EC +G W D I C E CP G F G ++ EA G
Sbjct: 1036 LAPNVTKQECCCTSGAGWGDNC-EIFPCPVLGTAEFTEMCP--KGKGFVPAGESSSEAGG 1092
Query: 472 P-----------GRCKIKNGGCWHEARNGHAFSACVDDGEVKCQCPAGFKGDGVK-NCQD 519
G+ KNG C + R G+ +C C G D VK C D
Sbjct: 1093 ENYKDADECLLFGQEICKNGFCLN-TRPGY-----------ECYCKQGTYYDPVKLQCFD 1140
Query: 520 VDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDHDTCISKTAS 566
+DEC++ +C + C NT GSY+C C+ ++ CI S
Sbjct: 1141 MDECQDPSSCI--DGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAES 1185
Score = 41.2 bits (95), Expect = 0.008
Identities = 18/44 (40%), Positives = 25/44 (55%), Gaps = 2/44 (4%)
Query: 504 QCPAGFKGDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSC 547
+C G+K CQD++EC+ + C P C NT GSY C+C
Sbjct: 285 ECLPGYKRVNNTFCQDINECQLQGVC--PNGECLNTMGSYRCTC 326
Score = 40.4 bits (93), Expect = 0.014
Identities = 37/135 (27%), Positives = 56/135 (41%), Gaps = 32/135 (23%)
Query: 417 VETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGYTTC----EASGP 472
V+ +EC + C + + C++T +C CP G +G T C E P
Sbjct: 587 VDIDECTQVQHLCSQGR------CENTEGSFLCICPA--GFMASEEG-TNCIDVDECLRP 637
Query: 473 GRCKIKNGGCWHEARNGHAFSACVDD-GEVKCQ-CPAGFKGDGVKNCQDVDECKEKKACQ 530
C GH CV+ G +C+ C +G++ C+D+DEC
Sbjct: 638 DVCG-----------EGH----CVNTVGAFRCEYCDSGYRMTQRGRCEDIDECLNPST-- 680
Query: 531 CPECSCKNTWGSYDC 545
CP+ C N+ GSY C
Sbjct: 681 CPDEQCVNSPGSYQC 695
Score = 38.5 bits (88), Expect = 0.054
Identities = 18/60 (30%), Positives = 30/60 (50%), Gaps = 2/60 (3%)
Query: 503 CQCPAGFK-GDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDHDTCI 561
C C G++ + + C D+DEC + + C + C+NT GS+ C C + + CI
Sbjct: 571 CICYEGYRFSEQQRKCVDIDECTQVQHL-CSQGRCENTEGSFLCICPAGFMASEEGTNCI 629
Score = 38.5 bits (88), Expect = 0.054
Identities = 25/64 (39%), Positives = 28/64 (43%), Gaps = 4/64 (6%)
Query: 488 NGHAFSACVDDGE-VKCQCPAGFKGDGVK-NCQDVDECKE--KKACQCPECSCKNTWGSY 543
NG CV E C C G+ D K C DV+EC E + C C NT GSY
Sbjct: 1302 NGCENGRCVRVQEGYTCDCLDGYHLDTAKMTCFDVNECDELNNRMSLCKNAKCINTDGSY 1361
Query: 544 DCSC 547
C C
Sbjct: 1362 KCLC 1365
>LTBL_HUMAN (Q14766) Latent transforming growth factor beta binding
protein, isoform 1L precursor (LTBP-1) (Transforming
growth factor beta-1 binding protein 1) (TGF-beta1-BP-1)
Length = 1595
Score = 58.5 bits (140), Expect = 5e-08
Identities = 54/176 (30%), Positives = 81/176 (45%), Gaps = 26/176 (14%)
Query: 400 CSGFEETTEPAVCLSSDVETNECLENNGGCWKDKAANITA----CKDTF---RGRVC--- 449
C +E EP VC + D LE + C K T C+D +G +C
Sbjct: 910 CLDVDECLEPNVCANGDCSN---LEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNG 966
Query: 450 ECPLVDGVQFK---GDGYTTCEASGPGRCKIKNGGCWHEARNGHAFSACVD-DGEVKCQC 505
+C +G F+ G GY A +C+ + C H R+ A C + +G +C C
Sbjct: 967 QCKNTEG-SFRCTCGQGYQLSAAKD--QCEDIDE-CQH--RHLCAHGQCRNTEGSFQCVC 1020
Query: 506 PAGFKGDGV-KNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDHDTC 560
G++ G+ +C+D++EC E K+ C C NT GSYDC+C D + D+ TC
Sbjct: 1021 DQGYRASGLGDHCEDINECLEDKSV-CQRGDCINTAGSYDCTCP-DGFQLDDNKTC 1074
Score = 55.1 bits (131), Expect = 6e-07
Identities = 28/72 (38%), Positives = 36/72 (49%), Gaps = 7/72 (9%)
Query: 499 GEVKCQCPAGFKGDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSC------SGDLL 552
G C CP GF+ D K CQD++EC+ C P+ C NT GS+ C C S D
Sbjct: 1056 GSYDCTCPDGFQLDDNKTCQDINECEHPGLCG-PQGECLNTEGSFHCVCQQGFSISADGR 1114
Query: 553 YIRDHDTCISKT 564
D D C++ T
Sbjct: 1115 TCEDIDECVNNT 1126
Score = 55.1 bits (131), Expect = 6e-07
Identities = 45/150 (30%), Positives = 56/150 (37%), Gaps = 31/150 (20%)
Query: 418 ETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGYTTC----EASGPG 473
+ NECLE+ C + N D C CP DG Q D TC E PG
Sbjct: 1035 DINECLEDKSVCQRGDCINTAGSYD------CTCP--DGFQL--DDNKTCQDINECEHPG 1084
Query: 474 RCKIKNGGCWHEARNGHAFSACVDDGEVKCQCPAGFK--GDGVKNCQDVDECKEKKACQC 531
C G C + +G C C GF DG + C+D+DEC C
Sbjct: 1085 LCG-PQGECLNT------------EGSFHCVCQQGFSISADG-RTCEDIDECVNNTVCDS 1130
Query: 532 PECSCKNTWGSYDCSCSGDLLYIRDHDTCI 561
C NT GS+ C C +D C+
Sbjct: 1131 -HGFCDNTAGSFRCLCYQGFQAPQDGQGCV 1159
Score = 48.9 bits (115), Expect = 4e-05
Identities = 48/167 (28%), Positives = 66/167 (38%), Gaps = 30/167 (17%)
Query: 413 LSSDVETNECLENNGGCWKDKAANITACKDTFRGRVCE-CPLVDGVQFKGDGYTTCEASG 471
L+ +V EC +G W D I C E CP G F G ++ EA G
Sbjct: 1237 LAPNVTKQECCCTSGAGWGDNC-EIFPCPVLGTAEFTEMCP--KGKGFVPAGESSSEAGG 1293
Query: 472 P-----------GRCKIKNGGCWHEARNGHAFSACVDDGEVKCQCPAGFKGDGVK-NCQD 519
G+ KNG C + R G+ +C C G D VK C D
Sbjct: 1294 ENYKDADECLLFGQEICKNGFCLN-TRPGY-----------ECYCKQGTYYDPVKLQCFD 1341
Query: 520 VDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDHDTCISKTAS 566
+DEC++ +C + C NT GSY+C C+ ++ CI S
Sbjct: 1342 MDECQDPSSCI--DGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAES 1386
Score = 41.2 bits (95), Expect = 0.008
Identities = 18/44 (40%), Positives = 25/44 (55%), Gaps = 2/44 (4%)
Query: 504 QCPAGFKGDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSC 547
+C G+K CQD++EC+ + C P C NT GSY C+C
Sbjct: 486 ECLPGYKRVNNTFCQDINECQLQGVC--PNGECLNTMGSYRCTC 527
Score = 40.4 bits (93), Expect = 0.014
Identities = 37/135 (27%), Positives = 56/135 (41%), Gaps = 32/135 (23%)
Query: 417 VETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGYTTC----EASGP 472
V+ +EC + C + + C++T +C CP G +G T C E P
Sbjct: 788 VDIDECTQVQHLCSQGR------CENTEGSFLCICPA--GFMASEEG-TNCIDVDECLRP 838
Query: 473 GRCKIKNGGCWHEARNGHAFSACVDD-GEVKCQ-CPAGFKGDGVKNCQDVDECKEKKACQ 530
C GH CV+ G +C+ C +G++ C+D+DEC
Sbjct: 839 DVCG-----------EGH----CVNTVGAFRCEYCDSGYRMTQRGRCEDIDECLNPST-- 881
Query: 531 CPECSCKNTWGSYDC 545
CP+ C N+ GSY C
Sbjct: 882 CPDEQCVNSPGSYQC 896
Score = 38.5 bits (88), Expect = 0.054
Identities = 25/64 (39%), Positives = 28/64 (43%), Gaps = 4/64 (6%)
Query: 488 NGHAFSACVDDGE-VKCQCPAGFKGDGVK-NCQDVDECKE--KKACQCPECSCKNTWGSY 543
NG CV E C C G+ D K C DV+EC E + C C NT GSY
Sbjct: 1503 NGCENGRCVRVQEGYTCDCLDGYHLDTAKMTCFDVNECDELNNRMSLCKNAKCINTDGSY 1562
Query: 544 DCSC 547
C C
Sbjct: 1563 KCLC 1566
Score = 38.5 bits (88), Expect = 0.054
Identities = 18/60 (30%), Positives = 30/60 (50%), Gaps = 2/60 (3%)
Query: 503 CQCPAGFK-GDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDHDTCI 561
C C G++ + + C D+DEC + + C + C+NT GS+ C C + + CI
Sbjct: 772 CICYEGYRFSEQQRKCVDIDECTQVQHL-CSQGRCENTEGSFLCICPAGFMASEEGTNCI 830
>GAS6_MOUSE (Q61592) Growth-arrest-specific protein 6 precursor
(GAS-6)
Length = 674
Score = 58.2 bits (139), Expect = 7e-08
Identities = 39/123 (31%), Positives = 47/123 (37%), Gaps = 21/123 (17%)
Query: 440 CKDTFRGRVCECPLVDGVQFKGDGYTTCEASGPGRCKIKNGGCWHEARNGHAFSACVDDG 499
C+D C C G G C+ C KNGGC N G
Sbjct: 130 CQDLMGNFFCVCT-------DGWGGRLCDKD-VNECVQKNGGCSQVCHN--------KPG 173
Query: 500 EVKCQCPAGFK--GDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSGDLLYIRDH 557
+C C +GF DG + CQD+DEC + C + CKN GSY C C Y
Sbjct: 174 SFQCACHSGFSLASDG-QTCQDIDECTDSDTCG--DARCKNLPGSYSCLCDEGYTYSSKE 230
Query: 558 DTC 560
TC
Sbjct: 231 KTC 233
Score = 55.1 bits (131), Expect = 6e-07
Identities = 45/156 (28%), Positives = 57/156 (35%), Gaps = 43/156 (27%)
Query: 416 DVETNECLENNGGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGY--------TTC 467
D + NEC++ NGGC + C + C C G DG T
Sbjct: 151 DKDVNECVQKNGGCSQ-------VCHNKPGSFQCACH--SGFSLASDGQTCQDIDECTDS 201
Query: 468 EASGPGRCKIKNGGCWHEARNGHAFSACVDDGEVKCQCPAGFK-GDGVKNCQDVDECKEK 526
+ G RCK G C C G+ K CQDVDEC++
Sbjct: 202 DTCGDARCKNL-------------------PGSYSCLCDEGYTYSSKEKTCQDVDECQQD 242
Query: 527 KACQCPECSCKNTWGSYDCSCS--GDLLYIRDHDTC 560
+ E +C N+ GSY C C G L D DTC
Sbjct: 243 RC----EQTCVNSPGSYTCHCDGRGGLKLSPDMDTC 274
>EGF_HUMAN (P01133) Pro-epidermal growth factor precursor (EGF)
[Contains: Epidermal growth factor (Urogastrone)]
Length = 1207
Score = 58.2 bits (139), Expect = 7e-08
Identities = 41/110 (37%), Positives = 53/110 (47%), Gaps = 19/110 (17%)
Query: 492 FSACVDDGE-VKCQCPAGFKGDGVKNCQDVDECKEKKACQCPECS--CKNTWGSYDCSCS 548
++ C+ +GE CQC GF GDG K C D+DEC E CP S C NT G Y C CS
Sbjct: 843 YARCISEGEDATCQCLKGFAGDG-KLCSDIDEC-EMGVPVCPPASSKCINTEGGYVCRCS 900
Query: 549 ----GDLLYIRDHDTC----------ISKTASQGGRSAWAAFWVIIAGLV 584
GD ++ D D C S T ++GG + A + GL+
Sbjct: 901 EGYQGDGIHCLDIDECQLGVHSCGENASCTNTEGGYTCMCAGRLSEPGLI 950
Score = 52.4 bits (124), Expect = 4e-06
Identities = 25/62 (40%), Positives = 36/62 (57%), Gaps = 2/62 (3%)
Query: 491 AFSACVD-DGEVKCQCPAGFKGDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDCSCSG 549
A S C++ +G C+C G++GDG+ +C D+DEC+ SC NT G Y C C+G
Sbjct: 884 ASSKCINTEGGYVCRCSEGYQGDGI-HCLDIDECQLGVHSCGENASCTNTEGGYTCMCAG 942
Query: 550 DL 551
L
Sbjct: 943 RL 944
Score = 39.3 bits (90), Expect = 0.032
Identities = 27/89 (30%), Positives = 38/89 (42%), Gaps = 14/89 (15%)
Query: 475 CKIKNGGCWHEARNGHAFSACVDDGEVK-CQCPAGFK-GDGVKNCQDVDECKE-KKACQC 531
CK++ G C + + C D + C C G+ K C+DV+EC C
Sbjct: 318 CKLRKGNC--------SSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTL 369
Query: 532 PECSCKNTWGSYDCSCSGDLLYIRDHDTC 560
CKNT GSY C+C + + D C
Sbjct: 370 ---GCKNTPGSYYCTCPVGFVLLPDGKRC 395
>EGF_RAT (P07522) Pro-epidermal growth factor precursor (EGF)
[Contains: Epidermal growth factor]
Length = 1133
Score = 57.4 bits (137), Expect = 1e-07
Identities = 38/124 (30%), Positives = 58/124 (46%), Gaps = 20/124 (16%)
Query: 427 GGCWKDKAANITACKDTFRGRVCECPLVDGVQFKGDGYTTCEASGPGRCKIKNGGCWHEA 486
GGC + C VC+C + G F GDG + C++ + C +
Sbjct: 842 GGC-----GSHAHCISEGEAAVCQC--LKG--FAGDGNLCSDID---ECELGSSDCPPTS 889
Query: 487 RNGHAFSACVD-DGEVKCQCPAGFKGDGVKNCQDVDECKEKKACQCPECSCKNTWGSYDC 545
S C++ +G CQC G++GDG+ C DVDEC++ +C NT G Y+C
Sbjct: 890 ------SRCINTEGGYVCQCSEGYEGDGIY-CLDVDECQQGSHGCSENATCTNTEGGYNC 942
Query: 546 SCSG 549
+C+G
Sbjct: 943 TCAG 946
Score = 42.0 bits (97), Expect = 0.005
Identities = 32/107 (29%), Positives = 43/107 (39%), Gaps = 14/107 (13%)
Query: 468 EASGPGRCKIKNGGCWHEARNGHAFSACVDDGEVKCQCPAGFK-GDGVKNCQDVDECKEK 526
+AS RCK + G C + D C G+ K C+DV+EC
Sbjct: 312 QASDSERCKQRRGQCLYSLSER-------DPNSDSSACAEGYTLSRDRKYCEDVNEC--- 361
Query: 527 KACQCPECS--CKNTWGSYDCSCSGDLLYIRDHDTCISKTASQGGRS 571
A Q C+ C+N GSY C+C + + D C A G RS
Sbjct: 362 -ALQNHGCTLGCENIPGSYYCTCPTGFVLLPDGKRCHELVACPGNRS 407
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.318 0.136 0.428
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 82,594,415
Number of Sequences: 164201
Number of extensions: 3896385
Number of successful extensions: 11262
Number of sequences better than 10.0: 322
Number of HSP's better than 10.0 without gapping: 92
Number of HSP's successfully gapped in prelim test: 232
Number of HSP's that attempted gapping in prelim test: 8690
Number of HSP's gapped (non-prelim): 1680
length of query: 631
length of database: 59,974,054
effective HSP length: 116
effective length of query: 515
effective length of database: 40,926,738
effective search space: 21077270070
effective search space used: 21077270070
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 69 (31.2 bits)
Lotus: description of TM0218.20