BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= TM0215b.5
(316 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
6DCS_SOYBN (P26690) NAD(P)H dependent 6'-deoxychalcone synthase ... 300 3e-81
ALDR_HORVU (P23901) Aldose reductase (EC 1.1.1.21) (AR) (Aldehyd... 146 8e-35
AKA1_RAT (P51635) Alcohol dehydrogenase [NADP+] (EC 1.1.1.2) (Al... 114 3e-25
AKA1_MOUSE (Q9JII6) Alcohol dehydrogenase [NADP+] (EC 1.1.1.2) (... 114 3e-25
AKA1_HUMAN (P14550) Alcohol dehydrogenase [NADP+] (EC 1.1.1.2) (... 110 4e-24
S6PD_MALDO (P28475) NADP-dependent D-sorbitol-6-phosphate dehydr... 110 5e-24
DDBX_BOVIN (P52898) Dihydrodiol dehydrogenase 3 (EC 1.-.-.-) (Pr... 110 5e-24
AKE1_MOUSE (Q9DCT1) Aldo-keto reductase family 1 member E1 (EC 1... 110 5e-24
AKA1_PIG (P50578) Alcohol dehydrogenase [NADP+] (EC 1.1.1.2) (Al... 110 5e-24
AKCD_MOUSE (Q8VC28) Aldo-keto reductase family 1 member C13 (EC ... 108 2e-23
DIDH_RAT (P23457) 3-alpha-hydroxysteroid dehydrogenase (EC 1.1.1... 108 2e-23
AKCD_MESAU (P82809) Aldo-keto reductase family 1 member C13 (EC ... 105 1e-22
DHB5_MOUSE (P70694) Estradiol 17 beta-dehydrogenase 5 (EC 1.1.1.... 103 4e-22
ALDR_PIG (P80276) Aldose reductase (EC 1.1.1.21) (AR) (Aldehyde ... 103 4e-22
AKA1_CRIGR (O70473) Alcohol dehydrogenase [NADP+] (EC 1.1.1.2) (... 103 6e-22
AKC2_HUMAN (P52895) Aldo-keto reductase family 1 member C2 (EC 1... 103 7e-22
AKC1_HUMAN (Q04828) Aldo-keto reductase family 1 member C1 (EC 1... 102 1e-21
PE2R_RABIT (P80508) Prostaglandin-E(2) 9-reductase (EC 1.1.1.189... 102 2e-21
PGFS_BOVIN (P05980) Prostaglandin-F synthase 1 (EC 1.1.1.188) (P... 101 3e-21
PGF2_BOVIN (P52897) Prostaglandin-F synthase 2 (EC 1.1.1.188) (P... 101 3e-21
>6DCS_SOYBN (P26690) NAD(P)H dependent 6'-deoxychalcone synthase (EC
1.1.-.-)
Length = 315
Score = 300 bits (768), Expect = 3e-81
Identities = 157/310 (50%), Positives = 214/310 (68%), Gaps = 7/310 (2%)
Query: 2 ATTTVPKVVLQSSTG*QRILVMGLSTAPEAANMIST*DVVLEAVKQGFKHFDAAAAYAVE 61
A +P +V +S+ QR+ V+G+ +AP+ T + ++EAVKQG++HFD AAAY E
Sbjct: 3 AAIEIPTIVFPNSSAQQRMPVVGMGSAPDFTCKKDTKEAIIEAVKQGYRHFDTAAAYGSE 62
Query: 62 QSVGAAIAEEHQH*LIASKDGLFVTSKVWVIDNHPELIVPALQKYLRTLQLEYLDLFLIH 121
Q++G A+ +E H + S+ LFVTSK+WV +NHP L++PAL+K L+TLQLEYLDL+LIH
Sbjct: 63 QALGEAL-KEAIHLGLVSRQDLFVTSKLWVTENHPHLVLPALRKSLKTLQLEYLDLYLIH 121
Query: 122 WPFATKQGAVKYPIEVLEIMEFGMQGV*SSMEESQRLGLTKAIGVNNLSIKKLDKLFCFA 181
WP +++ G +PIEV +++ F ++GV SMEE Q+LGLTKAIGV+N S+KKL L A
Sbjct: 122 WPLSSQPGKFSFPIEVEDLLPFDVKGVWESMEECQKLGLTKAIGVSNFSVKKLQNLLSVA 181
Query: 182 TISPVIDQVEVDLGWQQVKLRDFCKEKALYWQFGIIAFSPLRMGVSRGANLAMDNDIQKE 241
TI PV+DQVE++L WQQ KLR+FCKE + + AFSPLR G SRG N M+ND+ KE
Sbjct: 182 TIRPVVDQVEMNLAWQQKKLREFCKENGII----VTAFSPLRKGASRGPNEVMENDVLKE 237
Query: 242 L-DTHGKTIAQICL*WIYKH-VNFCDEEL*QGEDATKLAIFGCSLTENDFEKISEIHQER 299
+ + HGK+IAQ+ L W+Y+ V F + + L IF +LTE D KIS+I Q R
Sbjct: 238 IAEAHGKSIAQVSLRWLYEQGVTFVPKSYDKERMNQNLHIFDWALTEQDHHKISQISQSR 297
Query: 300 LIKEPTKPLL 309
LI PTKP L
Sbjct: 298 LISGPTKPQL 307
>ALDR_HORVU (P23901) Aldose reductase (EC 1.1.1.21) (AR) (Aldehyde
reductase)
Length = 320
Score = 146 bits (368), Expect = 8e-35
Identities = 88/255 (34%), Positives = 138/255 (53%), Gaps = 11/255 (4%)
Query: 48 GFKHFDAAAAYAVEQSVGAAIAEEHQH*LIASKDGLFVTSKVWVIDNHPELIVPALQKYL 107
G++H D AA Y VE+ VG + + + + LFVTSK+W + PE + PAL+ L
Sbjct: 50 GYRHVDTAAEYGVEKEVGKGLKAAMEAGI--DRKDLFVTSKIWCTNLAPERVRPALENTL 107
Query: 108 RTLQLEYLDLFLIHWPFATKQGAVKYPIEVLEIMEFGMQGV*SSMEESQRLGLTKAIGVN 167
+ LQL+Y+DL+ IHWPF K GA P E E++EF M+GV ME + GL K IGV
Sbjct: 108 KDLQLDYIDLYHIHWPFRLKDGA-HMPPEAGEVLEFDMEGVWKEMENLVKDGLVKDIGVC 166
Query: 168 NLSIKKLDKLFCFATISPVIDQVEVDLGWQQVKLRDFCKEKALYWQFGIIAFSPLRMGVS 227
N ++ KL++L A I P + Q+E+ GW+ K+ + CK+ ++ + A+SPL S
Sbjct: 167 NYTVTKLNRLLRSAKIPPAVCQMEMHPGWKNDKIFEACKKHGIH----VTAYSPLG---S 219
Query: 228 RGANLAMDNDIQKELDTHGKTIAQICL*W-IYKHVNFCDEEL*QGEDATKLAIFGCSLTE 286
NLA D ++K + KT Q+ + W + + + + + +FG + E
Sbjct: 220 SEKNLAHDPVVEKVANKLNKTPGQVLIKWALQRGTSVIPKSSKDERIKENIQVFGWEIPE 279
Query: 287 NDFEKISEIHQERLI 301
DF+ + I E+ +
Sbjct: 280 EDFKVLCSIKDEKRV 294
>AKA1_RAT (P51635) Alcohol dehydrogenase [NADP+] (EC 1.1.1.2)
(Aldehyde reductase) (Aldo-keto reductase family 1
member A1) (3-DG-reducing enzyme)
Length = 324
Score = 114 bits (285), Expect = 3e-25
Identities = 78/257 (30%), Positives = 129/257 (49%), Gaps = 18/257 (7%)
Query: 18 QRILVMGLSTAPEAANMIST*DVVLEAVKQGFKHFDAAAAYAVEQSVGAAIAEEHQH*LI 77
Q++ ++GL T + + A+ G++H D A+ Y E +G A+ E
Sbjct: 11 QKMPLIGLGTWKSEPGQVKA--AIKYALSVGYRHIDCASVYGNETEIGEALKESVGAGKA 68
Query: 78 ASKDGLFVTSKVWVIDNHPELIVPALQKYLRTLQLEYLDLFLIHWPFATKQGAVKYPIEV 137
++ LFVTSK+W +HPE + PA++K L LQLEYLDL+L+HWP+A ++G +P
Sbjct: 69 VPREELFVTSKLWNTKHHPEDVEPAVRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNA 128
Query: 138 LEIMEFG---MQGV*SSMEESQRLGLTKAIGVNNLSIKKLDKLFCFATISPVIDQVEVDL 194
+++ + ++E GL KA+G++N S +++D + A++ P + QVE
Sbjct: 129 DGTVKYDSTHYKETWKALEALVAKGLVKALGLSNFSSRQIDDVLSVASVRPAVLQVECHP 188
Query: 195 GWQQVKLRDFCKEKALYWQFGIIAFSPLRMGVSRGANLAMDNDIQKE-------LDTHGK 247
Q +L C+ + L + A+SPL G S A D + E + HG+
Sbjct: 189 YLAQNELIAHCQARGL----EVTAYSPL--GSSDRAWRHPDEPVLLEEPVVLALAEKHGR 242
Query: 248 TIAQICL*WIYKHVNFC 264
+ AQI L W + C
Sbjct: 243 SPAQILLRWQVQRKVIC 259
>AKA1_MOUSE (Q9JII6) Alcohol dehydrogenase [NADP+] (EC 1.1.1.2)
(Aldehyde reductase) (Aldo-keto reductase family 1
member A1)
Length = 324
Score = 114 bits (285), Expect = 3e-25
Identities = 78/257 (30%), Positives = 127/257 (49%), Gaps = 18/257 (7%)
Query: 18 QRILVMGLSTAPEAANMIST*DVVLEAVKQGFKHFDAAAAYAVEQSVGAAIAEEHQH*LI 77
Q++ ++GL T + + A+ G++H D A+ Y E +G A+ E
Sbjct: 11 QKMPLIGLGTWKSEPGQVKA--AIKHALSAGYRHIDCASVYGNETEIGEALKESVGSGKA 68
Query: 78 ASKDGLFVTSKVWVIDNHPELIVPALQKYLRTLQLEYLDLFLIHWPFATKQGAVKYPIEV 137
++ LFVTSK+W +HPE + PAL+K L LQLEYLDL+L+HWP+A ++G +P
Sbjct: 69 VPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNA 128
Query: 138 LEIMEFG---MQGV*SSMEESQRLGLTKAIGVNNLSIKKLDKLFCFATISPVIDQVEVDL 194
+ + + ++E GL KA+G++N + +++D + A++ P + QVE
Sbjct: 129 DGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPAVLQVECHP 188
Query: 195 GWQQVKLRDFCKEKALYWQFGIIAFSPLRMGVSRGANLAMDNDIQKE-------LDTHGK 247
Q +L C + L + A+SPL G S A D + E + HG+
Sbjct: 189 YLAQNELIAHCHARGL----EVTAYSPL--GSSDRAWRHPDEPVLLEEPVVLALAEKHGR 242
Query: 248 TIAQICL*WIYKHVNFC 264
+ AQI L W + C
Sbjct: 243 SPAQILLRWQVQRKVIC 259
>AKA1_HUMAN (P14550) Alcohol dehydrogenase [NADP+] (EC 1.1.1.2)
(Aldehyde reductase) (Aldo-keto reductase family 1
member A1)
Length = 324
Score = 110 bits (276), Expect = 4e-24
Identities = 78/257 (30%), Positives = 129/257 (49%), Gaps = 18/257 (7%)
Query: 18 QRILVMGLSTAPEAANMIST*DVVLEAVKQGFKHFDAAAAYAVEQSVGAAIAEEHQH*LI 77
Q++ ++GL T + V A+ G++H D AA Y E +G A+ E+
Sbjct: 11 QKMPLIGLGTWKSEPGQVKA--AVKYALSVGYRHIDCAAIYGNEPEIGEALKEDVGPGKA 68
Query: 78 ASKDGLFVTSKVWVIDNHPELIVPALQKYLRTLQLEYLDLFLIHWPFATKQGAVKYPIEV 137
++ LFVTSK+W +HPE + PAL+K L LQLEYLDL+L+HWP+A ++G +P
Sbjct: 69 VPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNA 128
Query: 138 LEIMEFG---MQGV*SSMEESQRLGLTKAIGVNNLSIKKLDKLFCFATISPVIDQVEVDL 194
+ + + ++E GL +A+G++N + +++D + A++ P + QVE
Sbjct: 129 DGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHP 188
Query: 195 GWQQVKLRDFCKEKALYWQFGIIAFSPLRMGVSRGANLAMDNDIQKE-------LDTHGK 247
Q +L C+ + L + A+SPL G S A D + E + +G+
Sbjct: 189 YLAQNELIAHCQARGL----EVTAYSPL--GSSDRAWRDPDEPVLLEEPVVLALAEKYGR 242
Query: 248 TIAQICL*WIYKHVNFC 264
+ AQI L W + C
Sbjct: 243 SPAQILLRWQVQRKVIC 259
>S6PD_MALDO (P28475) NADP-dependent D-sorbitol-6-phosphate
dehydrogenase (EC 1.1.1.200) (Aldose-6-phosphate
reductase [NADPH]) (NADP-S6PDH)
Length = 310
Score = 110 bits (275), Expect = 5e-24
Identities = 73/229 (31%), Positives = 122/229 (52%), Gaps = 17/229 (7%)
Query: 39 DVVLEAVKQGFKHFDAAAAYAVEQSVGAAIAEEHQH*LIASKDGLFVTSKVWVIDNHPEL 98
+V+L A+K G++HFD AA Y E VG A+AE + L+ ++ LF+T+K+W D+
Sbjct: 29 EVILNAIKIGYRHFDCAAHYKSEADVGEALAEAFKTGLV-KREELFITTKIWNSDHGH-- 85
Query: 99 IVPALQKYLRTLQLEYLDLFLIHWPFATKQGAVKYPI------EVLEI-MEFGMQGV*SS 151
+V A + L LQ++YLDL+L+H+P TK A+ +VL+I + +Q
Sbjct: 86 VVEACKNSLEKLQIDYLDLYLVHYPMPTKHNAIGKTASLLGEDKVLDIDVTISLQQTWEG 145
Query: 152 MEESQRLGLTKAIGVNNLSIKKLDKLFCFATISPVIDQVEVDLGWQQVKLRDFCKEKAL- 210
ME++ LGL ++IG++N + ++ I P + Q E +Q+ L FC + +
Sbjct: 146 MEKTVSLGLVRSIGLSNYELFLTRDCLAYSKIKPAVSQFETHPYFQRDSLVKFCMKHGVL 205
Query: 211 ---YWQFGIIAFSPLRMGVSRGANLAMDNDIQKELDTHGKTIAQICL*W 256
+ G A + G + + ND+ K+ +GK++AQICL W
Sbjct: 206 PTAHTPLGGAAANKDMFGSVSPLDDPVLNDVAKK---YGKSVAQICLRW 251
>DDBX_BOVIN (P52898) Dihydrodiol dehydrogenase 3 (EC 1.-.-.-)
(Prostaglandin F synthase)
Length = 323
Score = 110 bits (275), Expect = 5e-24
Identities = 85/295 (28%), Positives = 145/295 (48%), Gaps = 14/295 (4%)
Query: 20 ILVMGLST-APEAANMIST*DVVLEAVKQGFKHFDAAAAYAVEQSVGAAIAEEHQH*LIA 78
I V+G T AP +V A++ GF+H D+A Y E+ VG AI + +
Sbjct: 16 IPVLGFGTFAPREVPKSEALEVTKFAIEAGFRHIDSAHLYQNEEQVGQAIRSKIADGTVK 75
Query: 79 SKDGLFVTSKVWVIDNHPELIVPALQKYLRTLQLEYLDLFLIHWPFATKQGAVKYPIE-- 136
+D +F TSK+W PEL+ PAL+K L LQL+Y+DL++IH+P A K G +P +
Sbjct: 76 RED-IFYTSKLWSTSLRPELVRPALEKSLNNLQLDYVDLYIIHFPVALKPGETLFPTDEN 134
Query: 137 ---VLEIMEFGMQGV*SSMEESQRLGLTKAIGVNNLSIKKLDKLFCFATI--SPVIDQVE 191
+ + ++ + ++E+ + GLTK+IGV+N + K+L+K+ + PV +QVE
Sbjct: 135 GKPIFDSVD--LCRTWEALEKCKDAGLTKSIGVSNFNHKQLEKILNKPGLKYKPVCNQVE 192
Query: 192 VDLGWQQVKLRDFCKEKALYW-QFGIIAFSPLRMGVSRGANLAMDNDIQKEL-DTHGKTI 249
+ Q KL DFCK + +G + L+ V+ +++ + + H +T
Sbjct: 193 CHPYFNQSKLLDFCKSHDIVLVAYGALGSQRLKEWVNPNLPFLLEDPVLSAIAKKHRQTP 252
Query: 250 AQICL*W-IYKHVNFCDEEL*QGEDATKLAIFGCSLTENDFEKISEIHQERLIKE 303
A + L + I + V + + + +F LT D + I ++ E
Sbjct: 253 ALVALRYQIQRGVVVLAKSYNKKRIKENIQVFDFELTPEDMKAIDGLNSNMRYNE 307
>AKE1_MOUSE (Q9DCT1) Aldo-keto reductase family 1 member E1 (EC
1.1.1.-)
Length = 301
Score = 110 bits (275), Expect = 5e-24
Identities = 87/295 (29%), Positives = 142/295 (47%), Gaps = 15/295 (5%)
Query: 18 QRILVMGLSTAPEAANMIST*DVVLEAVKQGFKHFDAAAAYAVEQSVGAAIAEEHQH*LI 77
+ I +GL T + ++ D V A+ G++HFD A Y E VG I+E+ + ++
Sbjct: 2 ENIPTVGLGTWKASPGEVT--DAVKLAINLGYRHFDCAYLYHNESEVGMGISEKIKEGVV 59
Query: 78 ASKDGLFVTSKVWVIDNHPELIVPALQKYLRTLQLEYLDLFLIHWPFATKQGAVKYPIE- 136
+D LFV SK+W + L+ A L L L+YLDL+LIHWP K G P++
Sbjct: 60 KRED-LFVVSKLWCTCHKKSLVKTACTNTLEALNLDYLDLYLIHWPMGFKPGEKDIPLDR 118
Query: 137 --VLEIMEFGMQGV*SSMEESQRLGLTKAIGVNNLSIKKLDKLF--CFATISPVIDQVEV 192
+ +ME+ GL K +GV+N + ++L++L + P+ +Q+E
Sbjct: 119 NGKVIPSHTSFLDTWEAMEDLVFEGLVKNLGVSNFNHEQLERLLDKPGLRVRPITNQIEC 178
Query: 193 DLGWQQVKLRDFCKEKALYWQFGIIAFSPLRMGVSRGANLAMDNDIQKELDTHGKTIAQI 252
Q KL DFC ++ + A+ PL G G +L D I+K HGK+ AQI
Sbjct: 179 HPYLNQKKLIDFCHKR----NVSVTAYRPLG-GSGGGFHLMDDTVIRKIAKKHGKSPAQI 233
Query: 253 CL*W-IYKHVNFCDEEL*QGEDATKLAIFGCSLTENDFEKISEIHQE-RLIKEPT 305
+ + I +++ + + + +F LTE D E++ + + RL PT
Sbjct: 234 LIRFQIQRNLIVIPKSVTPSRIRENIQVFDFELTEKDMEELLSLDKNLRLATFPT 288
>AKA1_PIG (P50578) Alcohol dehydrogenase [NADP+] (EC 1.1.1.2)
(Aldehyde reductase) (Aldo-keto reductase family 1
member A1)
Length = 324
Score = 110 bits (275), Expect = 5e-24
Identities = 76/255 (29%), Positives = 127/255 (49%), Gaps = 14/255 (5%)
Query: 18 QRILVMGLSTAPEAANMIST*DVVLEAVKQGFKHFDAAAAYAVEQSVGAAIAEEHQH*LI 77
Q++ ++GL T + + A+ G++H D AA Y E +G A+ E
Sbjct: 11 QKMPLIGLGTWKSEPGQVKA--AIKYALTVGYRHIDCAAIYGNELEIGEALTETVGPGKA 68
Query: 78 ASKDGLFVTSKVWVIDNHPELIVPALQKYLRTLQLEYLDLFLIHWPFATKQGAVKYPIEV 137
++ LFVTSK+W +HPE + PAL+K L LQLEYLDL+L+HWP+A ++G +P
Sbjct: 69 VPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNA 128
Query: 138 LEIMEFG---MQGV*SSMEESQRLGLTKAIGVNNLSIKKLDKLFCFATISPVIDQVEVDL 194
+ + + ++E GL +A+G++N S +++D + A++ P + QVE
Sbjct: 129 DGTIRYDATHYKDTWKALEALVAKGLVRALGLSNFSSRQIDDVLSVASVRPAVLQVECHP 188
Query: 195 GWQQVKLRDFCKEKALYWQFGIIAFSPLRMG--VSRGAN---LAMDNDIQKELDTHGKTI 249
Q +L C+ + L + A+SPL R N L + +Q + + ++
Sbjct: 189 YLAQNELIAHCQARGL----EVTAYSPLGSSDRAWRDPNEPVLLEEPVVQALAEKYNRSP 244
Query: 250 AQICL*WIYKHVNFC 264
AQI L W + C
Sbjct: 245 AQILLRWQVQRKVIC 259
>AKCD_MOUSE (Q8VC28) Aldo-keto reductase family 1 member C13 (EC
1.1.1.-)
Length = 323
Score = 108 bits (270), Expect = 2e-23
Identities = 78/283 (27%), Positives = 148/283 (51%), Gaps = 20/283 (7%)
Query: 44 AVKQGFKHFDAAAAYAVEQSVGAAIAEEHQH*LIASKDGLFVTSKVWVIDNHPELIVPAL 103
A+ G++H D A AY VE+ +G AI + + ++ +D LF+T+K+W PEL+ PAL
Sbjct: 41 ALDVGYRHVDTAYAYQVEEEIGQAIQSKIKAGVVKRED-LFITTKLWCTCFRPELVKPAL 99
Query: 104 QKYLRTLQLEYLDLFLIHWPFATKQGAVKYPI-----EVLEIMEFGMQGV*SSMEESQRL 158
+K L+ LQL+Y+DL+++H+P K G +P+ +L+ ++F +EE +
Sbjct: 100 EKSLKKLQLDYVDLYIMHYPVPMKSGDNDFPVNEQGKSLLDTVDF--CDTWERLEECKDA 157
Query: 159 GLTKAIGVNNLSIKKLDKLFCFATI--SPVIDQVEVDLGWQQVKLRDFCKEKALYW-QFG 215
GL K+IGV+N + ++L+++ + PV +QVE L Q KL D+C+ K + +G
Sbjct: 158 GLVKSIGVSNFNHRQLERILNKPGLKYKPVCNQVECHLYLNQRKLLDYCESKDIVLVAYG 217
Query: 216 IIAFSPLRMGVSRGANLAMDNDIQKELDTHGK-TIAQICL*W-IYKHVNFCDEEL*QGED 273
+ + V + + + +++ + ++ K + A I L + I + + + + E
Sbjct: 218 ALGTQRYKEWVDQNSPVLLNDPVLCDVAKKNKRSPALIALRYLIQRGIVPLAQSFKENEM 277
Query: 274 ATKLAIFGCSLTENDFEKISEIHQ-------ERLIKEPTKPLL 309
L +FG L+ D + + +++ E L+ P P +
Sbjct: 278 RENLQVFGFQLSPEDMKTLDGLNKNFRYLPAEFLVDHPEYPFV 320
>DIDH_RAT (P23457) 3-alpha-hydroxysteroid dehydrogenase (EC
1.1.1.50) (3-alpha-HSD) (Hydroxyprostaglandin
dehydrogenase)
Length = 322
Score = 108 bits (269), Expect = 2e-23
Identities = 73/220 (33%), Positives = 117/220 (53%), Gaps = 23/220 (10%)
Query: 20 ILVMGL-STAPEAANMIST*DVVLEAVKQGFKHFDAAAAYAVEQSVGAAIAEEHQH*LIA 78
I V+G +T PE A+ GF+HFD+A Y VE+ VG AI + + +
Sbjct: 16 IPVLGFGTTVPEKVAKDEVIKATKIAIDNGFRHFDSAYLYEVEEEVGQAIRSKIEDGTVK 75
Query: 79 SKDGLFVTSKVWVIDNHPELIVPALQKYLRTLQLEYLDLFLIHWPFATKQGAVKYP---- 134
+D +F TSK+W + PEL+ L+K L++ QL+Y+DL++IH+P A + G + +P
Sbjct: 76 RED-IFYTSKLWSTFHRPELVRTCLEKTLKSTQLDYVDLYIIHFPMALQPGDIFFPRDEH 134
Query: 135 ----IEVLEIMEFGMQGV*SSMEESQRLGLTKAIGVNNLSIKKLDKLFCFATI--SPVID 188
E ++I + +ME+ + GL K+IGV+N + ++L+++ + PV +
Sbjct: 135 GKLLFETVDICD-----TWEAMEKCKDAGLAKSIGVSNFNCRQLERILNKPGLKYKPVCN 189
Query: 189 QVEVDLGWQQVKLRDFCKEKALYWQFGIIAFSPLRMGVSR 228
QVE L Q K+ D+CK K II S +G SR
Sbjct: 190 QVECHLYLNQSKMLDYCKSK------DIILVSYCTLGSSR 223
>AKCD_MESAU (P82809) Aldo-keto reductase family 1 member C13 (EC
1.1.1.-) (Morphine 6-dehydrogenase) (EC 1.1.1.218)
Length = 322
Score = 105 bits (263), Expect = 1e-22
Identities = 66/204 (32%), Positives = 115/204 (56%), Gaps = 23/204 (11%)
Query: 26 STAPEAANMIST*DVVLEAVKQGFKHFDAAAAYAVEQSVGAAIAEEHQH*LIASKDGLFV 85
S A EAAN+ A+ G++H D A AY +E+ +G AI + ++ +D +F+
Sbjct: 32 SKAMEAANL---------AIGVGYRHIDTAYAYQIEEEIGQAIQSNIKAGIVKRED-MFI 81
Query: 86 TSKVWVIDNHPELIVPALQKYLRTLQLEYLDLFLIHWPFATKQGAVKYPIE-----VLEI 140
T+K+W PEL+ P+L+K LQLE++DLF++H+P K G +P++ +L+
Sbjct: 82 TTKLWCTCFQPELVRPSLEKXXXKLQLEHVDLFIMHYPVPMKAGDNDFPLDEQGKLLLDT 141
Query: 141 MEFGMQGV*SSMEESQRLGLTKAIGVNNLSIKKLDKLFCFATI--SPVIDQVEVDLGWQQ 198
++F ++E+ GL K+IGV+N ++++L+++ + PV +QVE + Q
Sbjct: 142 VDF--CATWEALEKXXDAGLVKSIGVSNFNMRQLERILNKPGLKYKPVCNQVECHVYNNQ 199
Query: 199 VKLRDFCKEKALYWQFGIIAFSPL 222
KL D+CK K + ++AF L
Sbjct: 200 SKLLDYCKSKDIV----LVAFGAL 219
>DHB5_MOUSE (P70694) Estradiol 17 beta-dehydrogenase 5 (EC 1.1.1.-)
(17-beta-HSD 5)
Length = 323
Score = 103 bits (258), Expect = 4e-22
Identities = 81/291 (27%), Positives = 146/291 (49%), Gaps = 18/291 (6%)
Query: 20 ILVMGLST-APEAANMIST*DVVLEAVKQGFKHFDAAAAYAVEQSVGAAIAEEHQH*LIA 78
I ++G T AP+ + A+ GF+H D+A+ Y E+ VG AI + +
Sbjct: 16 IPILGFGTYAPQEVPKSKATEATKIAIDAGFRHIDSASMYQNEKEVGLAIRSKIADGTVK 75
Query: 79 SKDGLFVTSKVWVIDNHPELIVPALQKYLRTLQLEYLDLFLIHWPFATKQGAVKYPIEVL 138
+D +F TSKVW + PEL+ L++ L+ LQL+Y+DL+LIH+P A K G P +
Sbjct: 76 RED-IFYTSKVWCTFHRPELVRVCLEQSLKQLQLDYVDLYLIHFPMAMKPGENYLPKDEN 134
Query: 139 EIMEFGMQGV---*SSMEESQRLGLTKAIGVNNLSIKKLDKLFCFATI--SPVIDQVEVD 193
+ + + +ME+ + GL K+IGV+N + ++L+K+ + PV +QVE
Sbjct: 135 GKLIYDAVDICDTWEAMEKCKDAGLAKSIGVSNFNRRQLEKILKKPGLKYKPVCNQVECH 194
Query: 194 LGWQQVKLRDFCKEKALYWQFGIIAFSPL-----RMGVSRGANLAMDNDIQKEL-DTHGK 247
Q KL DFC+ K + ++A+S L + V + + + +DN + + + +
Sbjct: 195 PYLNQGKLLDFCRSKDIV----LVAYSALGSHREKQWVDQSSPVLLDNPVLGSMAKKYNR 250
Query: 248 TIAQICL*W-IYKHVNFCDEEL*QGEDATKLAIFGCSLTENDFEKISEIHQ 297
T A I L + + + V + + + +F LT D + + ++++
Sbjct: 251 TPALIALRYQLQRGVVVLAKSFSEKRIKENMQVFEFQLTSEDMKVLDDLNK 301
>ALDR_PIG (P80276) Aldose reductase (EC 1.1.1.21) (AR) (Aldehyde
reductase)
Length = 315
Score = 103 bits (258), Expect = 4e-22
Identities = 75/243 (30%), Positives = 120/243 (48%), Gaps = 17/243 (6%)
Query: 22 VMGLSTAPEAANMIST*DVVLEAVKQGFKHFDAAAAYAVEQSVGAAIAEEHQH*LIASKD 81
++GL T ++ + V A+ G++H D A Y E VG + E+ Q ++ +D
Sbjct: 14 ILGLGTWKSPPGKVT--EAVKVAIDLGYRHIDCAHVYQNENEVGLGLQEKLQGQVVKRED 71
Query: 82 GLFVTSKVWVIDNHPELIVPALQKYLRTLQLEYLDLFLIHWPFATKQGAVKYPIE---VL 138
LF+ SK+W D+ L+ A Q LR L+L+YLDL+LIHWP K G +P++ +
Sbjct: 72 -LFIVSKLWCTDHEKNLVKGACQTTLRDLKLDYLDLYLIHWPTGFKPGKDPFPLDGDGNV 130
Query: 139 EIMEFGMQGV*SSMEESQRLGLTKAIGVNNLSIKKLDKLFCFATI--SPVIDQVEVDLGW 196
E +MEE GL KAIGV+N + +++K+ + P ++Q+EV
Sbjct: 131 VPDESDFVETWEAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPAVNQIEVHPYL 190
Query: 197 QQVKLRDFCKEKALYWQFGIIAFSPL-----RMGVSRGANLAMDNDIQKELDTHGKTIAQ 251
Q KL ++CK K + + A+SPL +L D I+ + KT AQ
Sbjct: 191 TQEKLIEYCKSKGIV----VTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKYNKTTAQ 246
Query: 252 ICL 254
+ +
Sbjct: 247 VLI 249
>AKA1_CRIGR (O70473) Alcohol dehydrogenase [NADP+] (EC 1.1.1.2)
(Aldehyde reductase) (Aldo-keto reductase family 1
member A1) (Fragment)
Length = 228
Score = 103 bits (257), Expect = 6e-22
Identities = 61/182 (33%), Positives = 98/182 (53%), Gaps = 7/182 (3%)
Query: 44 AVKQGFKHFDAAAAYAVEQSVGAAIAEEHQH*LIASKDGLFVTSKVWVIDNHPELIVPAL 103
A+ G++H D AA Y E +G A+ E ++ LFVTSK+W +HPE + AL
Sbjct: 21 ALSVGYRHIDCAAVYGNEIEIGEALKENVGPGKAVPREELFVTSKLWNTKHHPEDVEAAL 80
Query: 104 QKYLRTLQLEYLDLFLIHWPFATKQGAVKYPIE---VLEIMEFGMQGV*SSMEESQRLGL 160
+K L LQLEYLDL+L+HWP+A ++G +P + + ++E GL
Sbjct: 81 RKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNDDGTIRYDSTHYKETWKALEALVAKGL 140
Query: 161 TKAIGVNNLSIKKLDKLFCFATISPVIDQVEVDLGWQQVKLRDFCKEKALYWQFGIIAFS 220
KA+G++N + +++D + A++ P + QVE Q +L C+ + L + A+S
Sbjct: 141 VKALGLSNFNSRQIDDILSVASVRPAVLQVECHPYLAQNELIAHCQARGL----EVTAYS 196
Query: 221 PL 222
PL
Sbjct: 197 PL 198
>AKC2_HUMAN (P52895) Aldo-keto reductase family 1 member C2 (EC
1.1.1.-) (Trans-1,2-dihydrobenzene-1,2-diol
dehydrogenase) (EC 1.3.1.20) (Chlordecone reductase
homolog HAKRD) (Dihydrodiol dehydrogenase/bile
acid-binding protein) (DD/BABP) (Dihydrodiol deh
Length = 323
Score = 103 bits (256), Expect = 7e-22
Identities = 71/207 (34%), Positives = 111/207 (53%), Gaps = 11/207 (5%)
Query: 22 VMGLST-APEAANMIST*DVVLEAVKQGFKHFDAAAAYAVEQSVGAAIAEEHQH*LIASK 80
V+G T AP + V A++ GF H D+A Y E+ VG AI + + +
Sbjct: 18 VLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKRE 77
Query: 81 DGLFVTSKVWVIDNHPELIVPALQKYLRTLQLEYLDLFLIHWPFATKQGAVKYPIEVLEI 140
D +F TSK+W + PEL+ PAL++ L+ LQL+Y+DL+LIH+P + K G P +
Sbjct: 78 D-IFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGK 136
Query: 141 MEF---GMQGV*SSMEESQRLGLTKAIGVNNLSIKKLDKLFCFATI--SPVIDQVEVDLG 195
+ F + +ME+ + GL K+IGV+N + + L+ + + PV +QVE
Sbjct: 137 ILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLKYKPVCNQVECHPY 196
Query: 196 WQQVKLRDFCKEKALYWQFGIIAFSPL 222
+ Q KL DFCK K + ++A+S L
Sbjct: 197 FNQRKLLDFCKSKDIV----LVAYSAL 219
>AKC1_HUMAN (Q04828) Aldo-keto reductase family 1 member C1 (EC
1.1.1.-) (Trans-1,2-dihydrobenzene-1,2-diol
dehydrogenase) (EC 1.3.1.20) (High-affinity hepatic bile
acid-binding protein) (HBAB) (Chlordecone reductase
homolog HAKRC) (Dihydrodiol dehydrogen
Length = 323
Score = 102 bits (254), Expect = 1e-21
Identities = 69/207 (33%), Positives = 112/207 (53%), Gaps = 11/207 (5%)
Query: 22 VMGLST-APEAANMIST*DVVLEAVKQGFKHFDAAAAYAVEQSVGAAIAEEHQH*LIASK 80
V+G T AP + A++ GF+H D+A Y E+ VG AI + + +
Sbjct: 18 VLGFGTYAPAEVPKSKALEATKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKRE 77
Query: 81 DGLFVTSKVWVIDNHPELIVPALQKYLRTLQLEYLDLFLIHWPFATKQGAVKYPIEVLEI 140
D +F TSK+W + PEL+ PAL++ L+ LQL+Y+DL+LIH+P + K G P +
Sbjct: 78 D-IFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGK 136
Query: 141 MEF---GMQGV*SSMEESQRLGLTKAIGVNNLSIKKLDKLFCFATI--SPVIDQVEVDLG 195
+ F + ++E+ + GL K+IGV+N + ++L+ + + PV +QVE
Sbjct: 137 ILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPY 196
Query: 196 WQQVKLRDFCKEKALYWQFGIIAFSPL 222
+ Q KL DFCK K + ++A+S L
Sbjct: 197 FNQRKLLDFCKSKDIV----LVAYSAL 219
>PE2R_RABIT (P80508) Prostaglandin-E(2) 9-reductase (EC 1.1.1.189)
(20-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.149)
(20-alpha-HSD)
Length = 323
Score = 102 bits (253), Expect = 2e-21
Identities = 71/214 (33%), Positives = 113/214 (52%), Gaps = 21/214 (9%)
Query: 20 ILVMGLST-APEAANMIST*DVVLEAVKQGFKHFDAAAAYAVEQSVGAAIAEEHQH*LIA 78
I V+G T APE + A+ GF+H D+A Y E+ VG AI + +
Sbjct: 16 IPVLGFGTYAPEEVPKSKAMEATKIAIDAGFRHIDSAYFYKNEKEVGLAIRSKIADGTVK 75
Query: 79 SKDGLFVTSKVWVIDNHPELIVPALQKYLRTLQLEYLDLFLIHWPFATKQGAVKYPIEVL 138
+D +F TSK+W + PEL+ P+L+ L+ LQL+Y+DL++IH+P A K G +E++
Sbjct: 76 RED-IFYTSKLWCTFHRPELVRPSLEDSLKNLQLDYVDLYIIHFPTALKPG-----VEII 129
Query: 139 EIMEFG--------MQGV*SSMEESQRLGLTKAIGVNNLSIKKLDKLFCFATI--SPVID 188
E G + +ME+ + GL K+IGV+N + ++L+ + + PV +
Sbjct: 130 PTDEHGKAIFDTVDICATWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCN 189
Query: 189 QVEVDLGWQQVKLRDFCKEKALYWQFGIIAFSPL 222
QVE Q KL +FCK K + ++A+S L
Sbjct: 190 QVECHPYLNQGKLLEFCKSKGIV----LVAYSAL 219
>PGFS_BOVIN (P05980) Prostaglandin-F synthase 1 (EC 1.1.1.188) (PGF
synthase 1) (PGF 1) (Prostaglandin-D2 11 reductase 1)
(PGFSI)
Length = 323
Score = 101 bits (251), Expect = 3e-21
Identities = 69/193 (35%), Positives = 105/193 (53%), Gaps = 7/193 (3%)
Query: 20 ILVMGLST-APEAANMIST*DVVLEAVKQGFKHFDAAAAYAVEQSVGAAIAEEHQH*LIA 78
I V+G T APE + A++ GF+H D+A Y E+ VG AI + +
Sbjct: 16 IPVLGFGTYAPEEVPKSEALEATKFAIEVGFRHVDSAHLYQNEEQVGQAIRSKIADGTVK 75
Query: 79 SKDGLFVTSKVWVIDNHPELIVPALQKYLRTLQLEYLDLFLIHWPFATKQGAVKYPIEVL 138
+D +F TSK+W PEL+ PAL+K L+ LQL+Y+DL++IH P + K G P +
Sbjct: 76 RED-IFYTSKLWCNSLQPELVRPALEKSLQNLQLDYVDLYIIHSPVSLKPGNKFVPKDES 134
Query: 139 EIMEF---GMQGV*SSMEESQRLGLTKAIGVNNLSIKKLDKLFCFATI--SPVIDQVEVD 193
+ F + ++E+ + GLTK+IGV+N + K+L+K+ + PV +QVE
Sbjct: 135 GKLIFDSVDLCHTWEALEKCKDAGLTKSIGVSNFNHKQLEKILNKPGLKYKPVCNQVECH 194
Query: 194 LGWQQVKLRDFCK 206
Q KL +FCK
Sbjct: 195 PYLNQSKLLEFCK 207
>PGF2_BOVIN (P52897) Prostaglandin-F synthase 2 (EC 1.1.1.188) (PGF
synthase 2) (PGF 2) (Prostaglandin-D2 11 reductase 2)
(PGFSII)
Length = 323
Score = 101 bits (251), Expect = 3e-21
Identities = 69/193 (35%), Positives = 105/193 (53%), Gaps = 7/193 (3%)
Query: 20 ILVMGLST-APEAANMIST*DVVLEAVKQGFKHFDAAAAYAVEQSVGAAIAEEHQH*LIA 78
I V+G T APE + A++ GF+H D+A Y E+ VG AI + +
Sbjct: 16 IPVLGFGTYAPEEVPKSEALEATKFAIEVGFRHVDSAHLYQNEEQVGQAIRSKIADGTVK 75
Query: 79 SKDGLFVTSKVWVIDNHPELIVPALQKYLRTLQLEYLDLFLIHWPFATKQGAVKYPIEVL 138
+D +F TSK+W PEL+ PAL+K L+ LQL+Y+DL++IH P + K G P +
Sbjct: 76 RED-IFYTSKLWCNSLQPELVRPALEKSLQNLQLDYVDLYIIHSPVSLKPGNKFVPKDES 134
Query: 139 EIMEF---GMQGV*SSMEESQRLGLTKAIGVNNLSIKKLDKLFCFATI--SPVIDQVEVD 193
+ F + ++E+ + GLTK+IGV+N + K+L+K+ + PV +QVE
Sbjct: 135 GKLIFDSVDLCHTWEALEKCKDAGLTKSIGVSNFNHKQLEKILNKPGLKYKPVCNQVECH 194
Query: 194 LGWQQVKLRDFCK 206
Q KL +FCK
Sbjct: 195 PYLNQSKLLEFCK 207
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.333 0.144 0.442
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,303,308
Number of Sequences: 164201
Number of extensions: 1242818
Number of successful extensions: 4442
Number of sequences better than 10.0: 91
Number of HSP's better than 10.0 without gapping: 77
Number of HSP's successfully gapped in prelim test: 14
Number of HSP's that attempted gapping in prelim test: 4162
Number of HSP's gapped (non-prelim): 99
length of query: 316
length of database: 59,974,054
effective HSP length: 110
effective length of query: 206
effective length of database: 41,911,944
effective search space: 8633860464
effective search space used: 8633860464
T: 11
A: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 39 (21.5 bits)
S2: 66 (30.0 bits)
Lotus: description of TM0215b.5