BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= TM0204.9
(716 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
KKB3_SCHPO (Q9P6P3) Putative serine/threonine-protein kinase C82... 219 3e-56
POM1_SCHPO (Q09690) Dual specificity protein kinase pom1 (EC 2.7... 216 2e-55
DYR3_DROME (P83102) Putative dual-specificity tyrosine-phosphory... 214 5e-55
KAB7_SCHPO (Q09815) Probable serine/threonine-protein kinase C16... 212 2e-54
DYR2_DROME (Q9V3D5) Dual-specificity tyrosine-phosphorylation re... 204 7e-52
YAK1_YEAST (P14680) Protein kinase YAK1 (EC 2.7.1.-) 204 9e-52
DYR4_HUMAN (Q9NR20) Dual-specificity tyrosine-phosphorylation re... 202 3e-51
DYR2_HUMAN (Q92630) Dual-specificity tyrosine-phosphorylation re... 199 2e-50
DYR3_HUMAN (O43781) Dual-specificity tyrosine-phosphorylation re... 194 7e-49
LKH1_SCHPO (Q10156) Protein kinase lkh1 (EC 2.7.1.37) (EC 2.7.1.... 192 2e-48
DYRB_HUMAN (Q9Y463) Dual-specificity tyrosine-phosphorylation re... 185 3e-46
MNB_DROME (P49657) Serine/threonine-protein kinase minibrain (EC... 184 5e-46
DYRB_MOUSE (Q9Z188) Dual-specificity tyrosine-phosphorylation re... 184 5e-46
DYRA_RAT (Q63470) Dual-specificity tyrosine-phosphorylation regu... 182 4e-45
DYRA_MOUSE (Q61214) Dual-specificity tyrosine-phosphorylation re... 182 4e-45
DYRA_HUMAN (Q13627) Dual-specificity tyrosine-phosphorylation re... 181 8e-45
CLK1_HUMAN (P49759) Dual specificity protein kinase CLK1 (EC 2.7... 167 1e-40
PR4B_MOUSE (Q61136) Serine/threonine-protein kinase PRP4 homolog... 162 3e-39
PR4B_HUMAN (Q13523) Serine/threonine-protein kinase PRP4 homolog... 162 3e-39
CLK1_MOUSE (P22518) Dual specificity protein kinase CLK1 (EC 2.7... 162 3e-39
>KKB3_SCHPO (Q9P6P3) Putative serine/threonine-protein kinase
C823.03 (EC 2.7.1.37)
Length = 534
Score = 219 bits (557), Expect = 3e-56
Identities = 132/345 (38%), Positives = 186/345 (53%), Gaps = 38/345 (11%)
Query: 398 VLNTVMAGRYYITEYLGSAAFSRVVQAHDLQTGTDVCLKIIKNDKDFFDQSLDEIKLLKL 457
+L T +Y I + LG F +V + DL+T V +K+IKN F++Q + E+ +L+L
Sbjct: 121 LLGTDEGRKYLILDTLGHGTFGQVARCQDLKTQQIVAIKVIKNKPAFYNQCVMEVSILEL 180
Query: 458 VN-KHDPADKHHILRLYDYFYHQEHLFIVTELLRANLYEFQKFNQESGGEAYFTLNRLQV 516
+N K+DP DK H++RLYD F H+ HL +V ELL NLYE K NQ G L+ ++
Sbjct: 181 LNNKYDPEDKRHLIRLYDQFMHKNHLCLVFELLSINLYELIKQNQFRG----LHLSLVRS 236
Query: 517 ITRQCLEALQYLHNLGIVHCDLKPENILIKSYKKCEIKVIDLGSSCFQTDNLCLYVQSRS 576
Q L L I+HCDLKPENIL++ +KVID GS+C + + Y+QSR
Sbjct: 237 FATQLLSCTSLLKQARIIHCDLKPENILLQDLSSPIVKVIDFGSACHERQTVYTYIQSRF 296
Query: 577 YRAPEVMLGLEYDEKIDIWSLGCILAELCSGEVLFPNDSVALILARMIGMLGPIDLEMLV 636
YR+PEV+LGL Y+ ID+WSLGCILAEL G LFP +S L R++ MLG ML
Sbjct: 297 YRSPEVILGLHYNCGIDMWSLGCILAELFLGLPLFPGNSEYNQLCRIVDMLGNPPTWMLE 356
Query: 637 KGKETHKYFT-------KEYDV-------------------YYANEETDQLEYIIPEESS 670
GK + KY+ K Y++ Y+ + D + P +
Sbjct: 357 MGKNSKKYYNSGFVNGRKTYELKSIEQFSIENNKTEQPGKQYFGEKTLDAIVLNYPRRKT 416
Query: 671 L-----EQHLQVTDAMFIDFVKYLLNINPKRRPTTKQALKHPWLS 710
E+H + FIDF+K L +NP +R T QA HP+++
Sbjct: 417 TPKLTPEEHEE--RLCFIDFIKQFLELNPLKRWTPDQAKNHPFIT 459
>POM1_SCHPO (Q09690) Dual specificity protein kinase pom1 (EC
2.7.1.37) (EC 2.7.1.112)
Length = 1087
Score = 216 bits (549), Expect = 2e-55
Identities = 122/326 (37%), Positives = 195/326 (59%), Gaps = 11/326 (3%)
Query: 388 GFEENK-ELPIVLNTVMAGRYYITEYLGSAAFSRVVQAHDLQTGTDVCLKIIKNDKDFFD 446
GF++ + + +VL +A RY + ++LG +F +V++ D +TG V LKII+N K F
Sbjct: 679 GFDDERGDYKVVLGDHIAYRYEVVDFLGKGSFGQVLRCIDYETGKLVALKIIRNKKRFHM 738
Query: 447 QSLDEIKLLKLVNKHDPADKHHILRLYDYFYHQEHLFIVTELLRANLYEFQKFNQESGGE 506
Q+L E K+L+ + + DP D++ +++ D+FY ++HL + TELL NLYE K N G
Sbjct: 739 QALVETKILQKIREWDPLDEYCMVQYTDHFYFRDHLCVATELLGKNLYELIKSNGFKG-- 796
Query: 507 AYFTLNRLQVITRQCLEALQYLHNLGIVHCDLKPENILIKSYKKCEIKVIDLGSSCFQTD 566
+ ++ ITRQ ++ L L+ ++HCDLKPENIL+ K ++KVID GSSCF+ +
Sbjct: 797 --LPIVVIKSITRQLIQCLTLLNEKHVIHCDLKPENILLCHPFKSQVKVIDFGSSCFEGE 854
Query: 567 NLCLYVQSRSYRAPEVMLGLEYDEKIDIWSLGCILAELCSGEVLFPNDSVALILARMIGM 626
+ Y+QSR YR+PEV+LG+ Y ID+WSLGCI+AE+ +G LFP ++ LA ++ +
Sbjct: 855 CVYTYIQSRFYRSPEVILGMGYGTPIDVWSLGCIIAEMYTGFPLFPGENEQEQLACIMEI 914
Query: 627 LGPIDLEMLVKGKETHKYF--TKEYDVYYANEETDQLEYIIPEESSLEQHLQVTDAMFID 684
GP D ++ K +F + + + +++ + P SL Q LQ D F+
Sbjct: 915 FGPPDHSLIDKCSRKKVFFDSSGKPRPFVSSKGVSRR----PFSKSLHQVLQCKDVSFLS 970
Query: 685 FVKYLLNINPKRRPTTKQALKHPWLS 710
F+ L +P R T +QA +H +L+
Sbjct: 971 FISDCLKWDPDERMTPQQAAQHDFLT 996
>DYR3_DROME (P83102) Putative dual-specificity
tyrosine-phosphorylation regulated kinase 3 homolog (EC
2.7.1.-)
Length = 828
Score = 214 bits (546), Expect = 5e-55
Identities = 122/322 (37%), Positives = 185/322 (56%), Gaps = 19/322 (5%)
Query: 403 MAGRYYITEYLGSAAFSRVVQAHDLQTGTDVCLKIIKNDKDFFDQSLDEIKLLKLVNKHD 462
+A RY + + +G +F +V++A+D +T V LKI++N+K F Q+ +EI++L + +HD
Sbjct: 272 VAYRYEMLKIIGKGSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQAQEEIRILHHLRRHD 331
Query: 463 PADKHHILRLYDYFYHQEHLFIVTELLRANLYEFQKFNQESGGEAYFTLNRLQVITRQCL 522
+ +I+ ++DYF + H I ELL NLYE K N G F+L ++ L
Sbjct: 332 KYNTMNIIHMFDYFTFRNHTCITFELLSINLYELIKKNGFKG----FSLQLVRKFAHSLL 387
Query: 523 EALQYLHNLGIVHCDLKPENILIKSYKKCEIKVIDLGSSCFQTDNLCLYVQSRSYRAPEV 582
+ L L+ I+HCD+KPEN+L+K + IKVID GSSCF+ + Y+QSR YRAPEV
Sbjct: 388 QCLDALYKNDIIHCDMKPENVLLKQQGRSGIKVIDFGSSCFENQRIYTYIQSRFYRAPEV 447
Query: 583 MLGLEYDEKIDIWSLGCILAELCSGEVLFPNDSVALILARMIGMLGPIDLEMLVKGKETH 642
+LG +Y ID+WSLGCILAEL SG LFP ++ + LA +I +LG + +L K +
Sbjct: 448 ILGGKYGRAIDMWSLGCILAELLSGHALFPGENESDQLACIIEVLGMPNKNILASSKRSK 507
Query: 643 KYFTKEYDVYYANEET--DQLEYII------------PEESSLEQHLQ-VTDAMFIDFVK 687
+F+ + Y T D + +I P SL + L D +F++F++
Sbjct: 508 SFFSPKGYPRYCTVRTMSDGMVVLIGGQSRRGKQRGPPCSKSLSKALDGCKDPLFLNFIR 567
Query: 688 YLLNINPKRRPTTKQALKHPWL 709
L + +R T +ALKHPWL
Sbjct: 568 GCLEWDADKRLTPSEALKHPWL 589
>KAB7_SCHPO (Q09815) Probable serine/threonine-protein kinase
C16C9.07 (EC 2.7.1.37)
Length = 836
Score = 212 bits (540), Expect = 2e-54
Identities = 118/320 (36%), Positives = 185/320 (56%), Gaps = 6/320 (1%)
Query: 390 EENKELPIVLNTVMAGRYYITEYLGSAAFSRVVQAHDLQTGTDVCLKIIKNDKDFFDQSL 449
++N + + + RY I + +G +F +V++ D + G V +K+IKN + F Q+L
Sbjct: 501 DDNGDYKAIQGDHLLYRYEIIDTVGKGSFGQVLKCIDHKRGQVVAIKVIKNRQKFHGQTL 560
Query: 450 DEIKLLKLVNKHDPADKHHILRLYDYFYHQEHLFIVTELLRANLYEFQKFNQESGGEAYF 509
E+ +LK + + DPADK++++R +F + HL IVTELL +NL++ + N G
Sbjct: 561 VEVGILKRLCEADPADKNNVIRYLSHFDFRGHLCIVTELLGSNLFDVIRENNYKG----L 616
Query: 510 TLNRLQVITRQCLEALQYLHNLGIVHCDLKPENILIKSYKKCEIKVIDLGSSCFQTDNLC 569
L ++ Q L+AL+ L I+HCDLKPEN+L+ K IK+ID GSSCF + +
Sbjct: 617 PLIVVKSFALQGLQALRLLQGQNIIHCDLKPENLLLSHPLKARIKLIDFGSSCFYNEKVY 676
Query: 570 LYVQSRSYRAPEVMLGLEYDEKIDIWSLGCILAELCSGEVLFPNDSVALILARMIGMLGP 629
Y+QSR YRAPE++LGLEY ++IDIWS GCILAEL +G LFP + L ++ +LGP
Sbjct: 677 TYLQSRFYRAPEIILGLEYGKEIDIWSFGCILAELFTGVPLFPGGNETEQLGYIMEVLGP 736
Query: 630 IDLEMLVKGKETHKYFTKEYDVYYANEETDQLEYIIPEESSLEQHLQVTDAMFIDFVKYL 689
+ ++ + YF E + + ++L ++P + Q L A F+DF+
Sbjct: 737 PPMALIRNSTRSKAYFDSEGKPHPITDSHNRL--LVPSTRTFSQLLNTKQASFLDFLSKC 794
Query: 690 LNINPKRRPTTKQALKHPWL 709
L +PK R T AL+H ++
Sbjct: 795 LKWDPKDRITVDSALQHEFI 814
>DYR2_DROME (Q9V3D5) Dual-specificity tyrosine-phosphorylation
regulated kinase 2 (EC 2.7.1.112) (EC 2.7.1.37) (dDyrk2)
(Smell impaired protein at 35A)
Length = 722
Score = 204 bits (519), Expect = 7e-52
Identities = 118/320 (36%), Positives = 181/320 (55%), Gaps = 6/320 (1%)
Query: 390 EENKELPIVLNTVMAGRYYITEYLGSAAFSRVVQAHDLQTGTDVCLKIIKNDKDFFDQSL 449
++N I+ + +A RY I E +G +F +V++A D +T T V +KII+N K F +Q++
Sbjct: 181 DDNGNYKIIEHDHIAFRYEILEVIGKGSFGQVIRALDHKTNTHVAIKIIRNKKRFLNQAV 240
Query: 450 DEIKLLKLVNKHDPADKHHILRLYDYFYHQEHLFIVTELLRANLYEFQKFNQESGGEAYF 509
E+ +L + + D H+++ + DY Y ++HL I EL+ NLYE K N +G F
Sbjct: 241 VELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMSLNLYELIKKNNYNG----F 296
Query: 510 TLNRLQVITRQCLEALQYLHNLGIVHCDLKPENILIKSYKKCEIKVIDLGSSCFQTDNLC 569
+++ ++ ++ L+ L+ I+HCDLKPENIL+K IKVID GSSC+ +
Sbjct: 297 SMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILLKQRGSSSIKVIDFGSSCYVDRKIY 356
Query: 570 LYVQSRSYRAPEVMLGLEYDEKIDIWSLGCILAELCSGEVLFPNDSVALILARMIGMLGP 629
Y+QSR YR+PEV+LGL+Y ID+WSLGCILAEL +G LFP ++ LA ++ +LG
Sbjct: 357 TYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQLACIMEVLG- 415
Query: 630 IDLEMLVKGKETHKYFTKEYDVYYANEETDQLEYIIPEESSLEQHLQVTDAMFIDFVKYL 689
+ ++L+ + F D T + P SL L D FIDF++
Sbjct: 416 LPPKVLISVARRRRLFFDSRDAPRCITNTKGRKR-SPGSKSLAHILHCQDRYFIDFLQRC 474
Query: 690 LNINPKRRPTTKQALKHPWL 709
L +P R T +A H +L
Sbjct: 475 LEWDPAERMTPDEAAHHEFL 494
>YAK1_YEAST (P14680) Protein kinase YAK1 (EC 2.7.1.-)
Length = 807
Score = 204 bits (518), Expect = 9e-52
Identities = 128/370 (34%), Positives = 201/370 (53%), Gaps = 48/370 (12%)
Query: 384 KNRTGFEE-NKELPIVLNTVMA----GRYYITEYLGSAAFSRVVQAHDLQTGTDVCLKII 438
K GF+ N + + +N V+ +Y + + LG F +VV+ +L T + +K++
Sbjct: 341 KCNNGFDNINSDYILYVNDVLGVEQNRKYLVLDILGQGTFGQVVKCQNLLTKEILAVKVV 400
Query: 439 KNDKDFFDQSLDEIKLLKLVN-KHDPADKHHILRLYDYFYHQEHLFIVTELLRANLYEFQ 497
K+ ++ QS+ E K+L+L+N K DP +KHH LR+YD F H+ HL +V ELL NLYE
Sbjct: 401 KSRTEYLTQSITEAKILELLNQKIDPTNKHHFLRMYDSFVHKNHLCLVFELLSNNLYELL 460
Query: 498 KFNQESGGEAYFTLNRLQVITRQCLEALQYLHNLGIVHCDLKPENILIKSYKKCEIKVID 557
K N+ G ++ ++ T Q L++L L ++HCDLKPENIL+ + K E+K+ID
Sbjct: 461 KQNKFHG----LSIQLIRTFTTQILDSLCVLKESKLIHCDLKPENILLCAPDKPELKIID 516
Query: 558 LGSSCFQTDNLCLYVQSRSYRAPEVMLGLEYDEKIDIWSLGCILAELCSGEVLFPNDSVA 617
GSSC + + Y+QSR YRAPE++LG+ Y ID+WSLGCI+AEL G +FP S
Sbjct: 517 FGSSCEEARTVYTYIQSRFYRAPEIILGIPYSTSIDMWSLGCIVAELFLGIPIFPGASEY 576
Query: 618 LILARMIGMLGPIDLEMLVKGKETHKY-----------------------FTKEYDV--- 651
L R+I LG M+ GK + K+ F +EY++
Sbjct: 577 NQLTRIIDTLGYPPSWMIDMGKNSGKFMKKLAPEESSSSTQKHRMKTIEEFCREYNIVEK 636
Query: 652 ----YYANEETDQL--EYIIPE-----ESSLEQHLQVTDAMFIDFVKYLLNINPKRRPTT 700
Y+ + + Y P+ + ++Q +Q + + I F+ +LN+NP R T
Sbjct: 637 PSKQYFKWRKLPDIIRNYRYPKSIQNSQELIDQEMQNRECL-IHFLGGVLNLNPLERWTP 695
Query: 701 KQALKHPWLS 710
+QA+ HP+++
Sbjct: 696 QQAMLHPFIT 705
>DYR4_HUMAN (Q9NR20) Dual-specificity tyrosine-phosphorylation
regulated kinase 4 (EC 2.7.1.-) (Fragment)
Length = 541
Score = 202 bits (514), Expect = 3e-51
Identities = 118/326 (36%), Positives = 181/326 (55%), Gaps = 7/326 (2%)
Query: 385 NRTGFEENKELPI-VLNTVMAGRYYITEYLGSAAFSRVVQAHDLQTGTDVCLKIIKNDKD 443
++T F++ + VL+ +A RY + E +G +F +V + D + V LKII+N K
Sbjct: 103 SKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNKKR 162
Query: 444 FFDQSLDEIKLLKLVNKHDPADKHHILRLYDYFYHQEHLFIVTELLRANLYEFQKFNQES 503
F Q+L E+K+L+ + K D + ++++ + D+FY + H I ELL NLYE K N
Sbjct: 163 FHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNNNFQ 222
Query: 504 GGEAYFTLNRLQVITRQCLEALQYLHNLGIVHCDLKPENILIKSYKKCEIKVIDLGSSCF 563
G F+L+ ++ T L+ LQ L I+HCDLKPENI++ + +KVID GSSC+
Sbjct: 223 G----FSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQKGQASVKVIDFGSSCY 278
Query: 564 QTDNLCLYVQSRSYRAPEVMLGLEYDEKIDIWSLGCILAELCSGEVLFPNDSVALILARM 623
+ + Y+QSR YR+PEV+LG YD ID+WSLGCI AEL +G LFP ++ LA +
Sbjct: 279 EHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLACI 338
Query: 624 IGMLGPIDLEMLVKGKETHKYFTKEYDVYYANEETDQLEYIIPEESSLEQHLQVTDAMFI 683
+ +LG + +F + + N ++ + P+ L L+ D F+
Sbjct: 339 MEVLGLPPAGFIQTASRRQTFFDSK--GFPKNITNNRGKKRYPDSKDLTMVLKTYDTSFL 396
Query: 684 DFVKYLLNINPKRRPTTKQALKHPWL 709
DF++ L P R T QALKH W+
Sbjct: 397 DFLRRCLVWEPSLRMTPDQALKHAWI 422
>DYR2_HUMAN (Q92630) Dual-specificity tyrosine-phosphorylation
regulated kinase 2 (EC 2.7.1.112) (EC 2.7.1.37)
Length = 528
Score = 199 bits (506), Expect = 2e-50
Identities = 120/341 (35%), Positives = 185/341 (54%), Gaps = 20/341 (5%)
Query: 385 NRTGFEENKELPI-VLNTVMAGRYYITEYLGSAAFSRVVQAHDLQTGTDVCLKIIKNDKD 443
N G+++++ + V + +A RY + + +G +F +VV+A+D + V LK+++N+K
Sbjct: 126 NNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKR 185
Query: 444 FFDQSLDEIKLLKLVNKHDPADKHHILRLYDYFYHQEHLFIVTELLRANLYEFQKFNQES 503
F Q+ +EI++L+ + K D + +++ + + F + H+ + ELL NLYE K N+
Sbjct: 186 FHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQ 245
Query: 504 GGEAYFTLNRLQVITRQCLEALQYLHNLGIVHCDLKPENILIKSYKKCEIKVIDLGSSCF 563
G F+L ++ L+ L LH I+HCDLKPENIL+K + IKVID GSSC+
Sbjct: 246 G----FSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCY 301
Query: 564 QTDNLCLYVQSRSYRAPEVMLGLEYDEKIDIWSLGCILAELCSGEVLFPNDSVALILARM 623
+ + Y+QSR YRAPEV+LG Y ID+WSLGCILAEL +G L P + LA M
Sbjct: 302 EHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACM 361
Query: 624 IGMLGPIDLEMLVKGKETHKYFTKEYDVYYANEETDQLEYII--------------PEES 669
I +LG ++L K + + + Y T ++ PE
Sbjct: 362 IELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESR 421
Query: 670 SLEQHLQ-VTDAMFIDFVKYLLNINPKRRPTTKQALKHPWL 709
L+ D +F+DF+K L +P R T QAL+HPWL
Sbjct: 422 EWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWL 462
>DYR3_HUMAN (O43781) Dual-specificity tyrosine-phosphorylation
regulated kinase 3 (EC 2.7.1.-)
Length = 588
Score = 194 bits (493), Expect = 7e-49
Identities = 114/324 (35%), Positives = 177/324 (54%), Gaps = 21/324 (6%)
Query: 403 MAGRYYITEYLGSAAFSRVVQAHDLQTGTDVCLKIIKNDKDFFDQSLDEIKLLKLVNKHD 462
+A RY + + +G +F +V + +D + V LK+++N+K F Q+ +EI++L+ + K D
Sbjct: 205 LAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQD 264
Query: 463 PADKHHILRLYDYFYHQEHLFIVTELLRANLYEFQKFNQESGGEAYFTLNRLQVITRQCL 522
+++ + + F + H+ + ELL +LYE K N+ G F++ ++ + L
Sbjct: 265 KTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQG----FSVQLVRKFAQSIL 320
Query: 523 EALQYLHNLGIVHCDLKPENILIKSYKKCEIKVIDLGSSCFQTDNLCLYVQSRSYRAPEV 582
++L LH I+HCDLKPENIL+K + + KVID GSSCF+ L Y+QSR YRAPE+
Sbjct: 321 QSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEI 380
Query: 583 MLGLEYDEKIDIWSLGCILAELCSGEVLFPNDSVALILARMIGMLGPIDLEMLVKGKETH 642
+LG Y IDIWS CILAEL +G+ LFP + LA M+ +LG ++L + K
Sbjct: 381 ILGSRYSTPIDIWSFRCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRA- 439
Query: 643 KYFTKEYDVYYANEETDQLEYII---------------PEESSLEQHLQ-VTDAMFIDFV 686
KYF + T Q + + P L+ D +FI+F+
Sbjct: 440 KYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFL 499
Query: 687 KYLLNINPKRRPTTKQALKHPWLS 710
K L+ +P R T QAL+HPW+S
Sbjct: 500 KRCLHWDPSARLTPAQALRHPWIS 523
>LKH1_SCHPO (Q10156) Protein kinase lkh1 (EC 2.7.1.37) (EC
2.7.1.112)
Length = 575
Score = 192 bits (489), Expect = 2e-48
Identities = 111/349 (31%), Positives = 190/349 (53%), Gaps = 28/349 (8%)
Query: 390 EENKELPIVLNTVMAGRYYITEYLGSAAFSRVVQAHDLQTGTDVCLKIIKNDKDFFDQSL 449
+++ +V N+ A RY + LG F +V+Q +D TG +K+ + + + SL
Sbjct: 230 DDDGHYKVVPNSKFANRYTVVRLLGHGTFGKVIQCYDQSTGRHCAIKVTRAIPKYREASL 289
Query: 450 DEIKLLKLVNKHDPADKHHILRLYDYFYHQEHLFIVTELLRANLYEFQKFNQESGGEAYF 509
E+++L+ + DP +++ ++L DYF +++H+ IVT+L ++++F K N F
Sbjct: 290 IELRVLQTIAHSDPTNENKCIQLRDYFDYRKHICIVTDLFGWSVFDFLKNNNYIP----F 345
Query: 510 TLNRLQVITRQCLEALQYLHNLGIVHCDLKPENILI-----------------KSYKKCE 552
L +Q++++Q +++ +LH+LG+VH DLKPEN+L+ K CE
Sbjct: 346 PLKHIQMLSQQLFKSVAFLHSLGLVHTDLKPENVLLVSNASRTIRLPYRNYSQKVLNSCE 405
Query: 553 IKVIDLGSSCFQTDNLCLYVQSRSYRAPEVMLGLEYDEKIDIWSLGCILAELCSGEVLFP 612
I++ID GS+ F+ + V +R YRAPE++LGL + D+WS+GCIL EL +G+ LF
Sbjct: 406 IRLIDFGSATFEDEYHSSVVSTRHYRAPEIILGLGWSYPCDVWSIGCILVELFTGQALFQ 465
Query: 613 NDSVALILARMIGMLGPIDLEMLVKGKET-HKYFTKEYDVYY--ANEETDQLEYIIPEES 669
+ L M +LGP D M+ + T ++F + V Y +N + Y +
Sbjct: 466 THEDSEHLCMMEKILGPFDRNMISRSSRTSQRFFKSDGKVRYPLSNTPKKSINY-LQSLQ 524
Query: 670 SLEQHLQVTD---AMFIDFVKYLLNINPKRRPTTKQALKHPWLSHVYKS 715
+LEQ V+ A+ +D +K + +PKRR T K+AL HP+ + S
Sbjct: 525 TLEQIFAVSSPEVALLLDLLKKVFVYDPKRRITAKEALWHPFFTQPISS 573
>DYRB_HUMAN (Q9Y463) Dual-specificity tyrosine-phosphorylation
regulated kinase 1B (EC 2.7.1.37) (EC 2.7.1.112) (Mirk
protein kinase) (Minibrain-related kinase)
Length = 629
Score = 185 bits (470), Expect = 3e-46
Identities = 118/323 (36%), Positives = 172/323 (52%), Gaps = 26/323 (8%)
Query: 406 RYYITEYLGSAAFSRVVQAHDLQTGTDVCLKIIKNDKDFFDQSLDEIKLLKLVNKHDPAD 465
RY I +G +F +VV+A+D QT V +KIIKN K F +Q+ E++LL+L+N+HD
Sbjct: 110 RYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEM 169
Query: 466 KHHILRLYDYFYHQEHLFIVTELLRANLYEFQKFNQESGGEAYFTLNRLQVITRQCLEAL 525
K++I+ L +F + HL +V ELL NLY+ + G +LN + + +Q AL
Sbjct: 170 KYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRG----VSLNLTRKLAQQLCTAL 225
Query: 526 QYLHN--LGIVHCDLKPENILIKSYKKCEIKVIDLGSSCFQTDNLCLYVQSRSYRAPEVM 583
+L L I+HCDLKPENIL+ + K+ IK++D GSSC + Y+QSR YR+PEV+
Sbjct: 226 LFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVL 285
Query: 584 LGLEYDEKIDIWSLGCILAELCSGEVLFPNDSVALILARMIGMLGPIDLEMLVKGKETHK 643
LG YD ID+WSLGCIL E+ +GE LF + + R++ +LG ML + + K
Sbjct: 286 LGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARK 345
Query: 644 YF------------TKEYDVYYANEETDQLEYII--------PEESSLEQHLQVTDAMFI 683
YF TKE Y T +L+ ++ + H F
Sbjct: 346 YFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQ 405
Query: 684 DFVKYLLNINPKRRPTTKQALKH 706
D V +L P R + AL+H
Sbjct: 406 DLVLRMLEYEPAARISPLGALQH 428
>MNB_DROME (P49657) Serine/threonine-protein kinase minibrain (EC
2.7.1.37)
Length = 843
Score = 184 bits (468), Expect = 5e-46
Identities = 117/339 (34%), Positives = 183/339 (53%), Gaps = 26/339 (7%)
Query: 390 EENKELPIVLNTVMAGRYYITEYLGSAAFSRVVQAHDLQTGTDVCLKIIKNDKDFFDQSL 449
++N + I RY I +G +F +VV+A+D + V +KIIKN K F +Q+
Sbjct: 82 DDNHDYIIKNGEKFLDRYEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQ 141
Query: 450 DEIKLLKLVNKHDPADKHHILRLYDYFYHQEHLFIVTELLRANLYEFQKFNQESGGEAYF 509
E+KLL+++N+ D +K++I++L +F + HL +V ELL NLY+ + G
Sbjct: 142 IEVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRG----V 197
Query: 510 TLNRLQVITRQCLEALQYLHN--LGIVHCDLKPENILIKSYKKCEIKVIDLGSSCFQTDN 567
+LN + +Q AL +L L I+HCDLKPENIL+ + K+ IK++D GSSC
Sbjct: 198 SLNLTRKFAQQLCTALLFLSTPELNIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQR 257
Query: 568 LCLYVQSRSYRAPEVMLGLEYDEKIDIWSLGCILAELCSGEVLFPNDSVALILARMIGML 627
+ Y+QSR YR+PEV+LG++YD ID+WSLGCIL E+ +GE LF + + +++ +L
Sbjct: 258 IYHYIQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVL 317
Query: 628 GPIDLEMLVKGKETHKYFTK--EYDVYYANEETDQLEYIIPEESSLEQHL---------- 675
G +L + +T K+F K Y + + +Y P L L
Sbjct: 318 GMPPKYLLDQAHKTRKFFDKIVADGSYVLKKNQNGRKYKPPGSRKLHDILGVETGGPGGR 377
Query: 676 -------QVTDAM-FIDFVKYLLNINPKRRPTTKQALKH 706
V+D + F D + +L+ +PK R T AL+H
Sbjct: 378 RLDEPGHSVSDYLKFKDLILRMLDFDPKTRVTPYYALQH 416
>DYRB_MOUSE (Q9Z188) Dual-specificity tyrosine-phosphorylation
regulated kinase 1B (EC 2.7.1.37) (EC 2.7.1.112)
Length = 589
Score = 184 bits (468), Expect = 5e-46
Identities = 102/244 (41%), Positives = 150/244 (60%), Gaps = 6/244 (2%)
Query: 406 RYYITEYLGSAAFSRVVQAHDLQTGTDVCLKIIKNDKDFFDQSLDEIKLLKLVNKHDPAD 465
RY I +G +F +VV+A+D QT V +KIIKN K F +Q+ E++LL+L+N+HD
Sbjct: 110 RYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEM 169
Query: 466 KHHILRLYDYFYHQEHLFIVTELLRANLYEFQKFNQESGGEAYFTLNRLQVITRQCLEAL 525
K++I+ L +F + HL +V ELL NLY+ + G +LN + + +Q AL
Sbjct: 170 KYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRG----VSLNLTRKLAQQLCTAL 225
Query: 526 QYLHN--LGIVHCDLKPENILIKSYKKCEIKVIDLGSSCFQTDNLCLYVQSRSYRAPEVM 583
+L L I+HCDLKPENIL+ + K+ IK++D GSSC + Y+QSR YR+PEV+
Sbjct: 226 LFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVL 285
Query: 584 LGLEYDEKIDIWSLGCILAELCSGEVLFPNDSVALILARMIGMLGPIDLEMLVKGKETHK 643
LG YD ID+WSLGCIL E+ +GE LF + ++R++ +LG ML + + K
Sbjct: 286 LGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMSRIVEVLGIPPAPMLEQAPKARK 345
Query: 644 YFTK 647
YF +
Sbjct: 346 YFER 349
>DYRA_RAT (Q63470) Dual-specificity tyrosine-phosphorylation
regulated kinase 1A (EC 2.7.1.-) (Protein kinase
minibrain homolog) (MNBH) (RP86) (Dual specificity
YAK1-related kinase)
Length = 763
Score = 182 bits (461), Expect = 4e-45
Identities = 122/352 (34%), Positives = 186/352 (52%), Gaps = 31/352 (8%)
Query: 382 HRKNRT----GFEENKELPIVLN-TVMAGRYYITEYLGSAAFSRVVQAHDLQTGTDVCLK 436
H+K R G++++ IV N RY I +G +F +VV+A+D V +K
Sbjct: 129 HKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIK 188
Query: 437 IIKNDKDFFDQSLDEIKLLKLVNKHDPADKHHILRLYDYFYHQEHLFIVTELLRANLYEF 496
IIKN K F +Q+ E++LL+L+NKHD K++I+ L +F + HL +V E+L NLY+
Sbjct: 189 IIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDL 248
Query: 497 QKFNQESGGEAYFTLNRLQVITRQCLEALQYLHN--LGIVHCDLKPENILIKSYKKCEIK 554
+ G +LN + +Q AL +L L I+HCDLKPENIL+ + K+ IK
Sbjct: 249 LRNTNFRG----VSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIK 304
Query: 555 VIDLGSSCFQTDNLCLYVQSRSYRAPEVMLGLEYDEKIDIWSLGCILAELCSGEVLFPND 614
++D GSSC + Y+QSR YR+PEV+LG+ YD ID+WSLGCIL E+ +GE LF
Sbjct: 305 IVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGA 364
Query: 615 SVALILARMIGMLGPIDLEMLVKGKETHKYFTKEYDVYYANEET--DQLEYIIPEESSLE 672
+ + +++ +LG +L + + K+F K D ++ ++T + EY P L
Sbjct: 365 NEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWSLKKTKDGKREYKPPGTRKLH 424
Query: 673 QHLQVTDA------------------MFIDFVKYLLNINPKRRPTTKQALKH 706
L V F D + +L+ +PK R AL+H
Sbjct: 425 NILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQH 476
>DYRA_MOUSE (Q61214) Dual-specificity tyrosine-phosphorylation
regulated kinase 1A (EC 2.7.1.-) (Protein kinase
minibrain homolog) (MNBH) (MP86) (Dual specificity
YAK1-related kinase)
Length = 763
Score = 182 bits (461), Expect = 4e-45
Identities = 122/352 (34%), Positives = 186/352 (52%), Gaps = 31/352 (8%)
Query: 382 HRKNRT----GFEENKELPIVLN-TVMAGRYYITEYLGSAAFSRVVQAHDLQTGTDVCLK 436
H+K R G++++ IV N RY I +G +F +VV+A+D V +K
Sbjct: 129 HKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIK 188
Query: 437 IIKNDKDFFDQSLDEIKLLKLVNKHDPADKHHILRLYDYFYHQEHLFIVTELLRANLYEF 496
IIKN K F +Q+ E++LL+L+NKHD K++I+ L +F + HL +V E+L NLY+
Sbjct: 189 IIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDL 248
Query: 497 QKFNQESGGEAYFTLNRLQVITRQCLEALQYLHN--LGIVHCDLKPENILIKSYKKCEIK 554
+ G +LN + +Q AL +L L I+HCDLKPENIL+ + K+ IK
Sbjct: 249 LRNTNFRG----VSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIK 304
Query: 555 VIDLGSSCFQTDNLCLYVQSRSYRAPEVMLGLEYDEKIDIWSLGCILAELCSGEVLFPND 614
++D GSSC + Y+QSR YR+PEV+LG+ YD ID+WSLGCIL E+ +GE LF
Sbjct: 305 IVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGA 364
Query: 615 SVALILARMIGMLGPIDLEMLVKGKETHKYFTKEYDVYYANEET--DQLEYIIPEESSLE 672
+ + +++ +LG +L + + K+F K D ++ ++T + EY P L
Sbjct: 365 NEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWSLKKTKDGKREYKPPGTRKLH 424
Query: 673 QHLQVTDA------------------MFIDFVKYLLNINPKRRPTTKQALKH 706
L V F D + +L+ +PK R AL+H
Sbjct: 425 NILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQH 476
>DYRA_HUMAN (Q13627) Dual-specificity tyrosine-phosphorylation
regulated kinase 1A (EC 2.7.1.-) (Protein kinase
minibrain homolog) (MNBH) (HP86) (Dual specificity
YAK1-related kinase)
Length = 763
Score = 181 bits (458), Expect = 8e-45
Identities = 122/352 (34%), Positives = 185/352 (51%), Gaps = 31/352 (8%)
Query: 382 HRKNRT----GFEENKELPIVLN-TVMAGRYYITEYLGSAAFSRVVQAHDLQTGTDVCLK 436
H+K R G++++ IV N RY I +G +F +VV+A+D V +K
Sbjct: 129 HKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIK 188
Query: 437 IIKNDKDFFDQSLDEIKLLKLVNKHDPADKHHILRLYDYFYHQEHLFIVTELLRANLYEF 496
IIKN K F +Q+ E++LL+L+NKHD K++I+ L +F + HL +V E+L NLY+
Sbjct: 189 IIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDL 248
Query: 497 QKFNQESGGEAYFTLNRLQVITRQCLEALQYLHN--LGIVHCDLKPENILIKSYKKCEIK 554
+ G +LN + +Q AL +L L I+HCDLKPENIL+ + K+ IK
Sbjct: 249 LRNTNFRG----VSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIK 304
Query: 555 VIDLGSSCFQTDNLCLYVQSRSYRAPEVMLGLEYDEKIDIWSLGCILAELCSGEVLFPND 614
++D GSSC + Y+QSR YR+PEV+LG+ YD ID+WSLGCIL E+ +GE LF
Sbjct: 305 IVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGA 364
Query: 615 SVALILARMIGMLGPIDLEMLVKGKETHKYFTKEYDVYYANEET--DQLEYIIPEESSLE 672
+ + +++ +LG +L + + K+F K D + ++T + EY P L
Sbjct: 365 NEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLH 424
Query: 673 QHLQVTDA------------------MFIDFVKYLLNINPKRRPTTKQALKH 706
L V F D + +L+ +PK R AL+H
Sbjct: 425 NILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQH 476
>CLK1_HUMAN (P49759) Dual specificity protein kinase CLK1 (EC
2.7.1.37) (EC 2.7.1.112) (CDC like kinase 1)
Length = 484
Score = 167 bits (422), Expect = 1e-40
Identities = 111/358 (31%), Positives = 187/358 (52%), Gaps = 31/358 (8%)
Query: 382 HRKNRT-GFEENKELPIVLNT--VMAGRYYITEYLGSAAFSRVVQAHDLQTG-TDVCLKI 437
HR+ RT E+++E ++ + V++ RY I + LG AF +VV+ D + G V +KI
Sbjct: 133 HRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKI 192
Query: 438 IKNDKDFFDQSLDEIKLLKLVNKHDPADKHHILRLYDYFYHQEHLFIVTELLRANLYEFQ 497
+KN + + + EI++L+ +N DP +++ ++F H H+ IV ELL + Y+F
Sbjct: 193 VKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFI 252
Query: 498 KFNQESGGEAYFTLNRLQVITRQCLEALQYLHNLGIVHCDLKPENILI------------ 545
K N G F L+ ++ + Q +++ +LH+ + H DLKPENIL
Sbjct: 253 KEN----GFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPK 308
Query: 546 -----KSYKKCEIKVIDLGSSCFQTDNLCLYVQSRSYRAPEVMLGLEYDEKIDIWSLGCI 600
++ +IKV+D GS+ + ++ V +R YRAPEV+L L + + D+WS+GCI
Sbjct: 309 IKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCI 368
Query: 601 LAELCSGEVLFPNDSVALILARMIGMLGPIDLEMLVKGKETHKYFTKEYDVYYANEETDQ 660
L E G +FP LA M +LGP+ M+ K ++ KYF +D +E +
Sbjct: 369 LIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRK-RKYF--HHDRLDWDEHSSA 425
Query: 661 LEYIIPEESSLEQHL---QVTDAMFIDFVKYLLNINPKRRPTTKQALKHPWLSHVYKS 715
Y+ L++ + V D ++ +L +P +R T ++ALKHP+ + KS
Sbjct: 426 GRYVSRACKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKS 483
>PR4B_MOUSE (Q61136) Serine/threonine-protein kinase PRP4 homolog (EC
2.7.1.37) (PRP4 pre-mRNA processing factor 4 homolog)
(Pre-mRNA protein kinase)
Length = 1007
Score = 162 bits (410), Expect = 3e-39
Identities = 107/335 (31%), Positives = 173/335 (50%), Gaps = 34/335 (10%)
Query: 399 LNTVMAGRYYITEYLGSAAFSRVVQAHD-LQTGTDVCLKIIKNDKDFFDQSLDEIKLLKL 457
+ V+ RY + Y G FS VV+A D + +V +KII+N++ L E++ LK
Sbjct: 679 IGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKK 738
Query: 458 VNKHDPADKHHILRLYDYFYHQEHLFIVTELLRANLYEFQKFNQESGGEAYFTLNRLQVI 517
+N DP DK H LRL+ +FYH++HL +V E L NL E K + G + + ++
Sbjct: 739 LNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLK---KYGKDVGLHIKAVRSY 795
Query: 518 TRQCLEALQYLHNLGIVHCDLKPENILIKSYKKCEIKVIDLGSSCFQTDN-LCLYVQSRS 576
++Q AL+ L I+H D+KP+NIL+ K +K+ D GS+ DN + Y+ SR
Sbjct: 796 SQQLFLALKLLKRCNILHADIKPDNILVNESKTI-LKLCDFGSASHVADNDITPYLVSRF 854
Query: 577 YRAPEVMLGLEYDEKIDIWSLGCILAELCSGEVLFPNDSVALILARMIGMLGPIDLEMLV 636
YRAPE+++G YD ID+WS+GC L EL +G++LFP + +L + + G + +M+
Sbjct: 855 YRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIR 914
Query: 637 KGKETHKYFTKEYDVYY-----------------ANEETDQLEYII-----PEESSLEQH 674
KG ++F + + Y N D L +I PE+ + H
Sbjct: 915 KGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKVH 974
Query: 675 LQVTDAMFIDFVKYLLNINPKRRPTTKQALKHPWL 709
D + +L ++P +R + QAL+H ++
Sbjct: 975 ------QLKDLLDQILMLDPAKRISINQALQHAFI 1003
>PR4B_HUMAN (Q13523) Serine/threonine-protein kinase PRP4 homolog (EC
2.7.1.37) (PRP4 pre-mRNA processing factor 4 homolog)
(PRP4 kinase)
Length = 1007
Score = 162 bits (410), Expect = 3e-39
Identities = 107/335 (31%), Positives = 173/335 (50%), Gaps = 34/335 (10%)
Query: 399 LNTVMAGRYYITEYLGSAAFSRVVQAHD-LQTGTDVCLKIIKNDKDFFDQSLDEIKLLKL 457
+ V+ RY + Y G FS VV+A D + +V +KII+N++ L E++ LK
Sbjct: 679 IGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKK 738
Query: 458 VNKHDPADKHHILRLYDYFYHQEHLFIVTELLRANLYEFQKFNQESGGEAYFTLNRLQVI 517
+N DP DK H LRL+ +FYH++HL +V E L NL E K + G + + ++
Sbjct: 739 LNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLK---KYGKDVGLHIKAVRSY 795
Query: 518 TRQCLEALQYLHNLGIVHCDLKPENILIKSYKKCEIKVIDLGSSCFQTDN-LCLYVQSRS 576
++Q AL+ L I+H D+KP+NIL+ K +K+ D GS+ DN + Y+ SR
Sbjct: 796 SQQLFLALKLLKRCNILHADIKPDNILVNESKTI-LKLCDFGSASHVADNDITPYLVSRF 854
Query: 577 YRAPEVMLGLEYDEKIDIWSLGCILAELCSGEVLFPNDSVALILARMIGMLGPIDLEMLV 636
YRAPE+++G YD ID+WS+GC L EL +G++LFP + +L + + G + +M+
Sbjct: 855 YRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIR 914
Query: 637 KGKETHKYFTKEYDVYY-----------------ANEETDQLEYII-----PEESSLEQH 674
KG ++F + + Y N D L +I PE+ + H
Sbjct: 915 KGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKVH 974
Query: 675 LQVTDAMFIDFVKYLLNINPKRRPTTKQALKHPWL 709
D + +L ++P +R + QAL+H ++
Sbjct: 975 ------QLKDLLDQILMLDPAKRISINQALQHAFI 1003
>CLK1_MOUSE (P22518) Dual specificity protein kinase CLK1 (EC
2.7.1.37) (EC 2.7.1.112) (CDC like kinase 1) (Protein
kinase STY)
Length = 483
Score = 162 bits (410), Expect = 3e-39
Identities = 108/351 (30%), Positives = 184/351 (51%), Gaps = 31/351 (8%)
Query: 382 HRKNRT-GFEENKELPIVLNT--VMAGRYYITEYLGSAAFSRVVQAHDLQTG-TDVCLKI 437
HR+ R+ E+++E ++ + V++ RY I + LG AF +VV+ D + G V +KI
Sbjct: 132 HRRKRSRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKVGGRRVAVKI 191
Query: 438 IKNDKDFFDQSLDEIKLLKLVNKHDPADKHHILRLYDYFYHQEHLFIVTELLRANLYEFQ 497
+KN + + + EI++L+ +N DP +++ ++F H+ H+ IV ELL + Y+F
Sbjct: 192 VKNVDRYCEAAQSEIQVLEHLNTTDPHSTFRCVQMLEWFEHRGHICIVFELLGLSTYDFI 251
Query: 498 KFNQESGGEAYFTLNRLQVITRQCLEALQYLHNLGIVHCDLKPENILI------------ 545
K N F ++ ++ + Q +++ +LH+ + H DLKPENIL
Sbjct: 252 KENSFLP----FRMDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVKSDYTEAYNPK 307
Query: 546 -----KSYKKCEIKVIDLGSSCFQTDNLCLYVQSRSYRAPEVMLGLEYDEKIDIWSLGCI 600
++ +IKV+D GS+ + ++ V +R YRAPEV+L L + + D+WS+GCI
Sbjct: 308 MKRDERTIVNPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCI 367
Query: 601 LAELCSGEVLFPNDSVALILARMIGMLGPIDLEMLVKGKETHKYFTKEYDVYYANEETDQ 660
L E G +FP LA M +LGP+ M+ K ++ +YF +D +E +
Sbjct: 368 LIEYYLGFTVFPTHDSREHLAMMERILGPLPKHMIQKTRK-RRYF--HHDRLDWDEHSSA 424
Query: 661 LEYIIPEESSLEQHLQVTDA---MFIDFVKYLLNINPKRRPTTKQALKHPW 708
Y+ L++ + DA D V +L +P +R T K+ALKHP+
Sbjct: 425 GRYVSRRCKPLKEFMLSQDAEHEFLFDLVGKILEYDPAKRITLKEALKHPF 475
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.317 0.137 0.405
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 91,282,705
Number of Sequences: 164201
Number of extensions: 4228180
Number of successful extensions: 16415
Number of sequences better than 10.0: 1639
Number of HSP's better than 10.0 without gapping: 1154
Number of HSP's successfully gapped in prelim test: 485
Number of HSP's that attempted gapping in prelim test: 12468
Number of HSP's gapped (non-prelim): 2375
length of query: 716
length of database: 59,974,054
effective HSP length: 117
effective length of query: 599
effective length of database: 40,762,537
effective search space: 24416759663
effective search space used: 24416759663
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 69 (31.2 bits)
Lotus: description of TM0204.9