BLASTP 2.2.2 [Dec-14-2001]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= TM0175.7
         (402 letters)

Database: sprot 
           164,201 sequences; 59,974,054 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

PRTZ_HORVU (P06293) Protein Z (Z4) (Major endosperm albumin)          295  2e-79
ANT3_MOUSE (P32261) Antithrombin-III precursor (ATIII)                181  4e-45
ANT3_HUMAN (P01008) Antithrombin-III precursor (ATIII) (PRO0309)      177  4e-44
SB10_HUMAN (P48595) Bomapin (Protease inhibitor 10) (Serpin B10)      177  6e-44
NEUS_CHICK (Q90935) Neuroserpin precursor (Axonin-2)                  176  7e-44
NEUS_RAT (Q9JLD2) Neuroserpin precursor (Protease inhibitor 17)       172  2e-42
ANT3_SHEEP (P32262) Antithrombin-III precursor (ATIII)                171  2e-42
ANT3_BOVIN (P41361) Antithrombin-III (ATIII)                          168  2e-41
PAI2_HUMAN (P05120) Plasminogen activator inhibitor-2 precursor ...   163  6e-40
SCC2_HUMAN (P48594) Squamous cell carcinoma antigen 2 (SCCA-2) (...   162  1e-39
ILEU_PIG (P80229) Leukocyte elastase inhibitor (LEI) (Leucocyte ...   161  2e-39
SPB9_HUMAN (P50453) Cytoplasmic antiproteinase 3 (CAP3) (CAP-3) ...   160  7e-39
NEUS_HUMAN (Q99574) Neuroserpin precursor (Protease inhibitor 12)     160  7e-39
ILEU_HUMAN (P30740) Leukocyte elastase inhibitor (LEI) (Monocyte...   156  8e-38
NEUS_MOUSE (O35684) Neuroserpin precursor (Protease inhibitor 17)     155  2e-37
PTI6_HUMAN (P35237) Placental thrombin inhibitor (Cytoplasmic an...   154  5e-37
PAI1_RAT (P20961) Plasminogen activator inhibitor-1 precursor (P...   153  9e-37
SCC1_HUMAN (P29508) Squamous cell carcinoma antigen 1 (SCCA-1) (...   152  1e-36
SPB8_HUMAN (P50452) Cytoplasmic antiproteinase 2 (CAP2) (CAP-2) ...   152  1e-36
PAI1_MUSVI (P50449) Plasminogen activator inhibitor-1 precursor ...   152  2e-36

>PRTZ_HORVU (P06293) Protein Z (Z4) (Major endosperm albumin)
          Length = 399

 Score =  295 bits (754), Expect = 2e-79
 Identities = 172/393 (43%), Positives = 246/393 (61%), Gaps = 11/393 (2%)

Query: 2   DLQKSIRCQTEVALSITKHLFSKEEYQEKNLVFSPFSLHAILSVMAVGSAGSTLDELFSF 61
           D++ SI  QT  AL +   + S  E    N+ FSP SLH  LS++  G+A +T D+L + 
Sbjct: 8   DVRLSIAHQTRFALRLRSAISSNPERAAGNVAFSPLSLHVALSLITAGAA-ATRDQLVAI 66

Query: 62  LR---FDSVDHLNTFFSQVLSTVLSD--TTPSFLLSFVNEMWADKSLALSHSFKQLMTTH 116
           L          LN    QV+  VL++  +T    ++F N ++ D SL+L  SF++L    
Sbjct: 67  LGDGGAGDAKELNALAEQVVQFVLANESSTGGPRIAFANGIFVDASLSLKPSFEELAVCQ 126

Query: 117 YKATLALVDFRTKGDQVCREVNSWVEKETNGLITELLPTNAVHKLTKLIFANALYFKGVW 176
           YKA    VDF+ K  +   +VNSWVE+ T GLI ++LP  +V   TKLI  NALYFKG W
Sbjct: 127 YKAKTQSVDFQHKTLEAVGQVNSWVEQVTTGLIKQILPPGSVDNTTKLILGNALYFKGAW 186

Query: 177 KHTFDPSMTFVDDFHLLNGTSIEVPFMSSEKKTQFIRTFDGFNVLRLSYKQGRDKKLRFS 236
              FD S T  D FHLL+G+SI+  FMSS KK Q+I + D   VL+L Y +G DK+ +FS
Sbjct: 187 DQKFDESNTKCDSFHLLDGSSIQTQFMSSTKK-QYISSSDNLKVLKLPYAKGHDKR-QFS 244

Query: 237 MCIFLPNAKDGLPSLIEKLASESCFLKGKLPRQKVRVRKFRIPKFKICFELEASNVLKEL 296
           M I LP A+DGL SL ++L++E  F++  +P+Q V V +F++PKFKI ++ EAS++L+ L
Sbjct: 245 MYILLPGAQDGLWSLAKRLSTEPEFIENHIPKQTVEVGRFQLPKFKISYQFEASSLLRAL 304

Query: 297 GVVSPFSKSNANFTKMVVSPLDELCVESIHHKASIEVNEEGTEAGVACSMCDVKLCVSAR 356
           G+  PFS+  A+ ++MV S    L +  + HK+ +EVNEEGTEAG A     V + +  +
Sbjct: 305 GLQLPFSE-EADLSEMVDSS-QGLEISHVFHKSFVEVNEEGTEAGAATVAMGVAMSMPLK 362

Query: 357 TG-IDFVADHPFLFLIREDLTGTILFIGQVLHP 388
              +DFVA+HPFLFLIRED+ G ++F+G V +P
Sbjct: 363 VDLVDFVANHPFLFLIREDIAGVVVFVGHVTNP 395


>ANT3_MOUSE (P32261) Antithrombin-III precursor (ATIII)
          Length = 465

 Score =  181 bits (458), Expect = 4e-45
 Identities = 112/386 (29%), Positives = 194/386 (50%), Gaps = 14/386 (3%)

Query: 8   RCQTEVALSITKHLFSKEEYQEKNLVFSPFSLHAILSVMAVGSAGSTLDELFSFLRFDSV 67
           +  +  A +  +HL   +   + N+  SP S+    ++  +G+   TL +L    +FD++
Sbjct: 86  KANSRFATNFYQHLADSKNDND-NIFLSPLSISTAFAMTKLGACNDTLKQLMEVFKFDTI 144

Query: 68  -----DHLNTFFSQVLSTVLSDTTPSFLLSFVNEMWADKSLALSHSFKQLMTTHYKATLA 122
                D ++ FF+++   +      S  L   N ++ DKSL  + S++ +    Y A L 
Sbjct: 145 SEKTSDQIHFFFAKLNCRLYRKANKSSDLVSANRLFGDKSLTFNESYQDVSEVVYGAKLQ 204

Query: 123 LVDFRTKGDQVCREVNSWVEKETNGLITELLPTNAVHKLTKLIFANALYFKGVWKHTFDP 182
            +DF+   +Q    +N+WV  +T G I +++P  A+++LT L+  N +YFKG+WK  F P
Sbjct: 205 PLDFKENPEQSRVTINNWVANKTEGRIKDVIPQGAINELTALVLVNTIYFKGLWKSKFSP 264

Query: 183 SMTFVDDFHLLNGTSIEVPFMSSEKKTQFIRTFDGFNVLRLSYKQGRDKKLRFSMCIFLP 242
             T  + F+ ++G S  VP M  E K ++ R  +G  VL L +K G D     +M + LP
Sbjct: 265 ENTRKEPFYKVDGQSCPVPMMYQEGKFKYRRVAEGTQVLELPFK-GDD----ITMVLILP 319

Query: 243 NAKDGLPSLIEKLASESCFLKGKLPRQKVRVRKFRIPKFKICFELEASNVLKELGVVSPF 302
             +  L  + ++L  E   L+  L      +    +P+F+          L+++G++  F
Sbjct: 320 KPEKSLAKVEQELTPE--LLQEWLDELSETMLVVHMPRFRTEDGFSLKEQLQDMGLIDLF 377

Query: 303 SKSNANFTKMVVSPLDELCVESIHHKASIEVNEEGTEAGVACSMCDVKLCVSARTGIDFV 362
           S   +    +V    D+L V    HKA +EVNEEG+EA  + S+      ++    + F 
Sbjct: 378 SPEKSQLPGIVAGGRDDLYVSDAFHKAFLEVNEEGSEAAASTSVVITGRSLNPNR-VTFK 436

Query: 363 ADHPFLFLIREDLTGTILFIGQVLHP 388
           A+ PFL LIRE    TI+F+G+V +P
Sbjct: 437 ANRPFLVLIREVALNTIIFMGRVANP 462


>ANT3_HUMAN (P01008) Antithrombin-III precursor (ATIII) (PRO0309)
          Length = 464

 Score =  177 bits (449), Expect = 4e-44
 Identities = 110/386 (28%), Positives = 193/386 (49%), Gaps = 14/386 (3%)

Query: 8   RCQTEVALSITKHLFSKEEYQEKNLVFSPFSLHAILSVMAVGSAGSTLDELFSFLRFDSV 67
           +  +  A +  +HL   +   + N+  SP S+    ++  +G+   TL +L    +FD++
Sbjct: 85  KANSRFATTFYQHLADSKNDND-NIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKFDTI 143

Query: 68  -----DHLNTFFSQVLSTVLSDTTPSFLLSFVNEMWADKSLALSHSFKQLMTTHYKATLA 122
                D ++ FF+++   +      S  L   N ++ DKSL  + +++ +    Y A L 
Sbjct: 144 SEKTSDQIHFFFAKLNCRLYRKANKSSKLVSANRLFGDKSLTFNETYQDISELVYGAKLQ 203

Query: 123 LVDFRTKGDQVCREVNSWVEKETNGLITELLPTNAVHKLTKLIFANALYFKGVWKHTFDP 182
            +DF+   +Q    +N WV  +T G IT+++P+ A+++LT L+  N +YFKG+WK  F P
Sbjct: 204 PLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAINELTVLVLVNTIYFKGLWKSKFSP 263

Query: 183 SMTFVDDFHLLNGTSIEVPFMSSEKKTQFIRTFDGFNVLRLSYKQGRDKKLRFSMCIFLP 242
             T  + F+  +G S     M  E K ++ R  +G  VL L +K G D     +M + LP
Sbjct: 264 ENTRKELFYKADGESCSASMMYQEGKFRYRRVAEGTQVLELPFK-GDD----ITMVLILP 318

Query: 243 NAKDGLPSLIEKLASESCFLKGKLPRQKVRVRKFRIPKFKICFELEASNVLKELGVVSPF 302
             +  L  + ++L  E   L+  L   +  +    +P+F+I         L+++G+V  F
Sbjct: 319 KPEKSLAKVEKELTPE--VLQEWLDELEEMMLVVHMPRFRIEDGFSLKEQLQDMGLVDLF 376

Query: 303 SKSNANFTKMVVSPLDELCVESIHHKASIEVNEEGTEAGVACSMCDVKLCVSARTGIDFV 362
           S   +    +V    D+L V    HKA +EVNEEG+EA  + ++      ++    + F 
Sbjct: 377 SPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAASTAVVIAGRSLNPNR-VTFK 435

Query: 363 ADHPFLFLIREDLTGTILFIGQVLHP 388
           A+ PFL  IRE    TI+F+G+V +P
Sbjct: 436 ANRPFLVFIREVPLNTIIFMGRVANP 461


>SB10_HUMAN (P48595) Bomapin (Protease inhibitor 10) (Serpin B10)
          Length = 397

 Score =  177 bits (448), Expect = 6e-44
 Identities = 120/400 (30%), Positives = 201/400 (50%), Gaps = 35/400 (8%)

Query: 12  EVALSITKHLFSKEEYQEKNLVFSPFSLHAILSVMAVGSAGSTLDELFSFLRFD------ 65
           + AL ++K L   E  Q KN+ FS +S+   L+++ +G+ G+T  ++   L+F+      
Sbjct: 10  QFALELSKKL--AESAQGKNIFFSSWSISTSLTIVYLGAKGTTAAQMAQVLQFNRDQGVK 67

Query: 66  ----------------SVDHLNTFFSQVLSTVLSDTTPSFLLSFVNEMWADKSLALSHSF 109
                           + + +++ F  ++S +L      +LL   N ++ +K+ A  + +
Sbjct: 68  CDPESEKKRKMEFNLSNSEEIHSDFQTLISEILKPND-DYLLKTANAIYGEKTYAFHNKY 126

Query: 110 KQLMTTHYKATLALVDFRTKGDQVCREVNSWVEKETNGLITELLPTNAVHKLTKLIFANA 169
            + M T++ A    V+F    DQ+ +++NSWVE++T G I  LLP ++V   T++I  NA
Sbjct: 127 LEDMKTYFGAEPQPVNFVEASDQIRKDINSWVERQTEGKIQNLLPDDSVDSTTRMILVNA 186

Query: 170 LYFKGVWKHTFDPSMTFVDDFHLLNGTSIEVPFMSSEKKTQFIRTFDGFNVLRLSYKQGR 229
           LYFKG+W+H F    T    F +   TS  V  M  +KK           V    Y + R
Sbjct: 187 LYFKGIWEHQFLVQNTTEKPFRINETTSKPVQMMFMKKKLHIFHIEKPKAVGLQLYYKSR 246

Query: 230 DKKLRFSMCIFLPNAKDGLPSLIEKLASESCFLKGKLPRQKVRVRKFRIPKFKICFELEA 289
           D     S+ I LP   +GL  L + +  E           ++   +  +PKFK+    + 
Sbjct: 247 D----LSLLILLPEDINGLEQLEKAITYEKLNEWTSADMMELYEVQLHLPKFKLEDSYDL 302

Query: 290 SNVLKELGVVSPFSKSNANFTKMVVSPLDELCVESIHHKASIEVNEEGTEAGVAC-SMCD 348
            + L  +G+   FS+S A+F+ M  S    L + ++ HKA +E+NE+GTEA     S  D
Sbjct: 303 KSTLSSMGMSDAFSQSKADFSGM--SSARNLFLSNVFHKAFVEINEQGTEAAAGSGSEID 360

Query: 349 VKLCVSARTGIDFVADHPFLFLIREDLTGTILFIGQVLHP 388
           +++ V +   I+F A+HPFLF IR + T TILF G++  P
Sbjct: 361 IRIRVPS---IEFNANHPFLFFIRHNKTNTILFYGRLCSP 397


>NEUS_CHICK (Q90935) Neuroserpin precursor (Axonin-2)
          Length = 410

 Score =  176 bits (447), Expect = 7e-44
 Identities = 123/390 (31%), Positives = 199/390 (50%), Gaps = 25/390 (6%)

Query: 10  QTEVALSITKHLFSKEEYQEKNLVFSPFSLHAILSVMAVGSAGSTLDELFSFLRFDSVDH 69
           +T   LS+  +   +   +++N++F P S+   + ++ +G+ G+TL E+   L FDS+ +
Sbjct: 24  ETIAELSVNVYNQLRAAREDENILFCPLSIAIAMGMIELGAHGTTLKEIRHSLGFDSLKN 83

Query: 70  LNTF-FSQVLSTVLSDTTPSFLLSFVNEMWADKSLALSHSFKQLMTTHYKATLALVDFRT 128
              F F + LS + +     ++L+  N ++      +S  F QL+  ++KA +  +DF +
Sbjct: 84  GEEFTFLKDLSDMATTEESHYVLNMANSLYVQNGFHVSEKFLQLVKKYFKAEVENIDF-S 142

Query: 129 KGDQVCREVNSWVEKETNGLITELLPTNAVHKLTKLIFANALYFKGVWKHTFDPSMTFVD 188
           +   V   +N WVE  TN +I + + +     LT L+  NA+YFKG WK  F P  T   
Sbjct: 143 QSAAVATHINKWVENHTNNMIKDFVSSRDFSALTHLVLINAIYFKGNWKSQFRPENTRTF 202

Query: 189 DFHLLNGTSIEVPFMSSEKKTQFIRTFDGFN-------VLRLSYKQGRDKKLRFSMCIFL 241
            F   + T +++P M  + +  +    DG N       VL + Y+         SM I L
Sbjct: 203 SFTKDDETEVQIPMMYQQGEFYYGEFSDGSNEAGGIYQVLEIPYEGD-----EISMMIVL 257

Query: 242 PNAKDGLPSLIEKLASESCFLK--GKLPRQKVRVRKFRIPKFKICFELEASNVLKELGVV 299
              +  L +L E L   S   +    + +QKV V    +P+F +  E++  +VLK LG+ 
Sbjct: 258 SRQEVPLVTL-EPLVKASLINEWANSVKKQKVEV---YLPRFTVEQEIDLKDVLKGLGIT 313

Query: 300 SPFSKSNANFTKMVVSPLDELCVESIHHKASIEVNEEGTEAGVACSMCDVKLCVSARTGI 359
             FS+S A+ T M  S   EL +    HKA +EVNEEG+EA  A  M  + +   A    
Sbjct: 314 EVFSRS-ADLTAM--SDNKELYLAKAFHKAFLEVNEEGSEAAAASGM--IAISRMAVLYP 368

Query: 360 DFVADHPFLFLIREDLTGTILFIGQVLHPE 389
             + DHPF FL+R   TGT+LF+G+V+HPE
Sbjct: 369 QVIVDHPFFFLVRNRRTGTVLFMGRVMHPE 398


>NEUS_RAT (Q9JLD2) Neuroserpin precursor (Protease inhibitor 17)
          Length = 410

 Score =  172 bits (435), Expect = 2e-42
 Identities = 126/397 (31%), Positives = 202/397 (50%), Gaps = 45/397 (11%)

Query: 12  EVALSITKHLFSKEEYQEKNLVFSPFSLHAILSVMAVGSAGSTLDELFSFLRFDSVDHLN 71
           E ++++  HL +  E  ++N++FSP S+   + VM +G+ GSTL E+   + ++S+    
Sbjct: 28  EWSVNVYNHLRATGE--DENILFSPLSIALAMGVMELGAQGSTLKEIRHSMGYESLKSGE 85

Query: 72  TF-FSQVLSTVLSDTTPSFLLSFVNEMWADKSLALSHSFKQLMTTHYKATLALVDFRTKG 130
            F F +  S+++S     +++   N ++      ++  F Q+M  ++ A +  VDF ++ 
Sbjct: 86  EFSFLRDFSSMVSAEEGQYVMKIANSLFVQNGFHINEEFLQMMKMYFNAEVNHVDF-SEN 144

Query: 131 DQVCREVNSWVEKETNGLITELLPTNAVHKLTKLIFANALYFKGVWKHTFDPSMTFVDDF 190
             V   +N WVE  TN L+ +L+       +T L   NA+YFKG WK  F P  T    F
Sbjct: 145 VAVANYINKWVENYTNSLLKDLVSPGDFDAVTHLALINAVYFKGNWKSQFRPENTRTFSF 204

Query: 191 HLLNGTSIEVPFMSSEKKTQFIRTFDGFN-------VLRLSYKQGRDKKLRFSMCIFLPN 243
              + + +++P M  + +  +    DG N       VL + Y+         SM + L  
Sbjct: 205 TKDDESEVQIPMMYQQGEFYYGEFSDGSNEAGGIYQVLEIPYEGD-----EISMMLVLSR 259

Query: 244 AKDGL--------PSLIEKLASESCFLKGKLPRQKVRVRKFRIPKFKICFELEASNVLKE 295
            +  L        P LIE+ A+        + +QKV V    +P+F +  E++  ++LK 
Sbjct: 260 QEVPLATLEPLLKPQLIEEWAN-------SVKKQKVEV---YLPRFTVEQEIDLKDILKA 309

Query: 296 LGVVSPFSKSNANFTKMVVSPLDELCVESIHHKASIEVNEEGTEAGVACSMCDVKLCVSA 355
           LGV   F K +AN T M  S   EL +    HK+ IEVNEEG+EA VA  M  +     +
Sbjct: 310 LGVTEIFIK-DANLTAM--SDKKELFLSKAVHKSFIEVNEEGSEAAVASGMIAI-----S 361

Query: 356 RTGIDF---VADHPFLFLIREDLTGTILFIGQVLHPE 389
           R  + F   + DHPFLFLI+   TGTILF+G+V+HPE
Sbjct: 362 RMAVLFPQVIVDHPFLFLIKNRKTGTILFMGRVMHPE 398


>ANT3_SHEEP (P32262) Antithrombin-III precursor (ATIII)
          Length = 465

 Score =  171 bits (434), Expect = 2e-42
 Identities = 107/386 (27%), Positives = 189/386 (48%), Gaps = 14/386 (3%)

Query: 8   RCQTEVALSITKHLFSKEEYQEKNLVFSPFSLHAILSVMAVGSAGSTLDELFSFLRFDSV 67
           +  +  A +  +HL   +   + N+  SP S+    ++  +G+  +TL +L    +FD++
Sbjct: 86  KANSHFATAFYQHLADSKNNND-NIFLSPLSISTAFAMTKLGACNNTLKQLMEVFKFDTI 144

Query: 68  -----DHLNTFFSQVLSTVLSDTTPSFLLSFVNEMWADKSLALSHSFKQLMTTHYKATLA 122
                D ++ FF+++   +      S  L   N ++ DKS+  + +++ +    Y A L 
Sbjct: 145 SEKTSDQIHFFFAKLNCRLYRKANKSSELVSANRLFGDKSITFNETYQDISEVVYGAKLQ 204

Query: 123 LVDFRTKGDQVCREVNSWVEKETNGLITELLPTNAVHKLTKLIFANALYFKGVWKHTFDP 182
            +DF+   +Q    +N W+  +T G IT+++P  A+ + T L+  N +YFKG+WK  F P
Sbjct: 205 PLDFKGNAEQSRLTINQWISNKTEGRITDVIPPQAIDEFTVLVLVNTIYFKGLWKSKFSP 264

Query: 183 SMTFVDDFHLLNGTSIEVPFMSSEKKTQFIRTFDGFNVLRLSYKQGRDKKLRFSMCIFLP 242
             T  + F+  +G S  VP M  E K ++ R  +G  VL L +K G D     +M + LP
Sbjct: 265 ENTKKELFYKADGESCSVPMMYQEGKFRYRRVAEGTQVLELPFK-GDD----ITMVLILP 319

Query: 243 NAKDGLPSLIEKLASESCFLKGKLPRQKVRVRKFRIPKFKICFELEASNVLKELGVVSPF 302
             +  L  +  +L  +   L+  L      +    +P F+I         L+++G+   F
Sbjct: 320 KLEKPLAKVERELTPD--MLQEWLDELTETLLVVHMPHFRIEDSFSVKEQLQDMGLEDLF 377

Query: 303 SKSNANFTKMVVSPLDELCVESIHHKASIEVNEEGTEAGVACSMCDVKLCVSARTGIDFV 362
           S   +    +V    ++L V    HKA +EVNEEG+EA  +  +      ++    + F 
Sbjct: 378 SPEKSRLPGIVAEGRNDLYVSDAFHKAFLEVNEEGSEAAASTVISIAGRSLNLNR-VTFQ 436

Query: 363 ADHPFLFLIREDLTGTILFIGQVLHP 388
           A+ PFL LIRE    TI+F+G+V +P
Sbjct: 437 ANRPFLVLIREVALNTIIFMGRVANP 462


>ANT3_BOVIN (P41361) Antithrombin-III (ATIII)
          Length = 433

 Score =  168 bits (426), Expect = 2e-41
 Identities = 105/386 (27%), Positives = 190/386 (49%), Gaps = 14/386 (3%)

Query: 8   RCQTEVALSITKHLFSKEEYQEKNLVFSPFSLHAILSVMAVGSAGSTLDELFSFLRFDSV 67
           +  +  A +  +HL   +   + N+  SP S+    ++  +G+  +TL +L    +FD++
Sbjct: 54  KANSHFATAFYQHLADSKNNND-NIFLSPLSISTAFAMTKLGACNNTLTQLMEVFKFDTI 112

Query: 68  -----DHLNTFFSQVLSTVLSDTTPSFLLSFVNEMWADKSLALSHSFKQLMTTHYKATLA 122
                D ++ FF+++   +      S  L   N ++ DKS+  + +++ +    Y A L 
Sbjct: 113 SEKTSDQIHFFFAKLNCRLYRKANKSSELVSANRLFGDKSITFNETYQDISEVVYGAKLQ 172

Query: 123 LVDFRTKGDQVCREVNSWVEKETNGLITELLPTNAVHKLTKLIFANALYFKGVWKHTFDP 182
            +DF+   +Q    +N W+  +T G IT+++P  A+++ T L+  N +YFKG+WK  F P
Sbjct: 173 PLDFKGNAEQSRLTINQWISNKTEGRITDVIPPQAINEFTVLVLVNTIYFKGLWKSKFSP 232

Query: 183 SMTFVDDFHLLNGTSIEVPFMSSEKKTQFIRTFDGFNVLRLSYKQGRDKKLRFSMCIFLP 242
             T  + F+  +G S  V  M  E K ++ R  +   VL L +K G D     +M + LP
Sbjct: 233 ENTRKELFYKADGESCSVLMMYQESKFRYRRVAESTQVLELPFK-GDD----ITMVLILP 287

Query: 243 NAKDGLPSLIEKLASESCFLKGKLPRQKVRVRKFRIPKFKICFELEASNVLKELGVVSPF 302
             +  L  + ++L  +   L+  L      +    +P+F+I         L+++G+   F
Sbjct: 288 KLEKTLAKVEQELTPD--MLQEWLDELTETLLVVHMPRFRIEDSFSVKEQLQDMGLEDLF 345

Query: 303 SKSNANFTKMVVSPLDELCVESIHHKASIEVNEEGTEAGVACSMCDVKLCVSARTGIDFV 362
           S   +    +V     +L V    HKA +EVNEEG+EA  +  +      +++   + F 
Sbjct: 346 SPEKSRLPGIVAEGRSDLYVSDAFHKAFLEVNEEGSEAAASTVISIAGRSLNS-DRVTFK 404

Query: 363 ADHPFLFLIREDLTGTILFIGQVLHP 388
           A+ PFL LIRE    TI+F+G+V +P
Sbjct: 405 ANRPFLVLIREVALNTIIFMGRVANP 430


>PAI2_HUMAN (P05120) Plasminogen activator inhibitor-2 precursor
           (PAI-2) (Placental plasminogen activator inhibitor)
           (Monocyte Arg-serpin) (Urokinase inhibitor)
          Length = 415

 Score =  163 bits (413), Expect = 6e-40
 Identities = 121/424 (28%), Positives = 205/424 (47%), Gaps = 63/424 (14%)

Query: 11  TEVALSITKHLFSKEEYQEKNLVFSPFSLHAILSVMAVGSAGSTLDELFSFLRFDSV--- 67
           T  AL++ KHL      Q  NL  SP+S+ + ++++ +GS GST D++   L+F+ V   
Sbjct: 9   TLFALNLFKHLAKASPTQ--NLFLSPWSISSTMAMVYMGSRGSTEDQMAKVLQFNEVGAN 66

Query: 68  ----------------------------------DHLNTFFSQVLSTVLSDTTPSFLLSF 93
                                             D +++ F   LS+ ++ +T ++LL  
Sbjct: 67  AVTPMTPENFTSCGFMQQIQKGSYPDAILQAQAADKIHSSFRS-LSSAINASTGNYLLES 125

Query: 94  VNEMWADKSLALSHSFKQLMTTHYKATLALVDFRTKGDQVCREVNSWVEKETNGLITELL 153
           VN+++ +KS +    + +L   +Y +    VDF    ++  +++NSWV+ +T G I  LL
Sbjct: 126 VNKLFGEKSASFREEYIRLCQKYYSSEPQAVDFLECAEEARKKINSWVKTQTKGKIPNLL 185

Query: 154 PTNAVHKLTKLIFANALYFKGVWKHTFDPSMTFVDDFHLLNG--TSIEVPFMSSEKKTQF 211
           P  +V   T+++  NA+YFKG WK  F+  +  +  F + +   T +++ ++  +    +
Sbjct: 186 PEGSVDGDTRMVLVNAVYFKGKWKTPFEKKLNGLYPFRVNSAQRTPVQMMYLREKLNIGY 245

Query: 212 IRTFDGFNVLRLSYKQGRDKKLRFSMCIFLPNAKDGLPSLIEKLASESCF-------LKG 264
           I       +L L Y          SM + LP+    + + +E L SE  +        K 
Sbjct: 246 IEDLKA-QILELPYAGD------VSMFLLLPDEIADVSTGLELLESEITYDKLNKWTSKD 298

Query: 265 KLPRQKVRVRKFRIPKFKICFELEASNVLKELGVVSPFSKSNANFTKMVVSPLDELCVES 324
           K+   +V V    IP+FK+    E  ++L+ +G+   F+K  ANF+ M  S  ++L +  
Sbjct: 299 KMAEDEVEV---YIPQFKLEEHYELRSILRSMGMEDAFNKGRANFSGM--SERNDLFLSE 353

Query: 325 IHHKASIEVNEEGTEAGVACSMCDVKLCVSARTGIDFVADHPFLFLIREDLTGTILFIGQ 384
           + H+A ++VNEEGTEA  A     V    +   G  FVADHPFLFLI   +T  ILF G+
Sbjct: 354 VFHQAMVDVNEEGTEA--AAGTGGVMTGRTGHGGPQFVADHPFLFLIMHKITNCILFFGR 411

Query: 385 VLHP 388
              P
Sbjct: 412 FSSP 415


>SCC2_HUMAN (P48594) Squamous cell carcinoma antigen 2 (SCCA-2)
           (Leupin)
          Length = 390

 Score =  162 bits (411), Expect = 1e-39
 Identities = 112/386 (29%), Positives = 185/386 (47%), Gaps = 43/386 (11%)

Query: 28  QEKNLVFSPFSLHAILSVMAVGSAGSTLDELFSFLRFDSVDHLNTFFS------------ 75
           +E N+ +SP S+ + L ++ +G+  +T  ++   L FD V    T  +            
Sbjct: 23  KENNIFYSPISITSALGMVLLGAKDNTAQQISKVLHFDQVTENTTEKAATYHVDRSGNVH 82

Query: 76  ---QVLSTVLSDTTPSFLLSFVNEMWADKSLALSHSFKQLMTTHYKATLALVDFRTKGDQ 132
              Q L T  + +T ++ L   N+++ +K+      +   +   Y+ ++   DF    ++
Sbjct: 83  HQFQKLLTEFNKSTDAYELKIANKLFGEKTYQFLQEYLDAIKKFYQTSVESTDFANAPEE 142

Query: 133 VCREVNSWVEKETNGLITELLPTNAVHKLTKLIFANALYFKGVWKHTFDPSMTFVDDFHL 192
             +++NSWVE +TN  I  L P   +   T L+  NA+YFKG W++ F    T  + F  
Sbjct: 143 SRKKINSWVESQTNEKIKNLFPDGTIGNDTTLVLVNAIYFKGQWENKFKKENTKEEKFW- 201

Query: 193 LNGTSIEVPFMSSEKKTQFIRTFDGFN----------VLRLSYKQGRDKKLRFSMCIFLP 242
                   P  ++ K  Q +R ++ FN          VL + YK G+D     SM + LP
Sbjct: 202 --------PNKNTYKSVQMMRQYNSFNFALLEDVQAKVLEIPYK-GKD----LSMIVLLP 248

Query: 243 NAKDGLPSLIEKLASESCFLKGKLPRQKVRVRKFRIPKFKICFELEASNVLKELGVVSPF 302
           N  DGL  L EKL +E       L   +       +P+FK+    +  + L+ +G+V+ F
Sbjct: 249 NEIDGLQKLEEKLTAEKLMEWTSLQNMRETCVDLHLPRFKMEESYDLKDTLRTMGMVNIF 308

Query: 303 SKSNANFTKMVVSPLDELCVESIHHKASIEVNEEGTEAGVACSMCDVKLCVSARTGIDFV 362
           +  +A+ + M  S    L V  + HKA +EV EEG EA  A ++  V+L  S  T  +F 
Sbjct: 309 N-GDADLSGMTWS--HGLSVSKVLHKAFVEVTEEGVEAAAATAVVVVELS-SPSTNEEFC 364

Query: 363 ADHPFLFLIREDLTGTILFIGQVLHP 388
            +HPFLF IR++ T +ILF G+   P
Sbjct: 365 CNHPFLFFIRQNKTNSILFYGRFSSP 390


>ILEU_PIG (P80229) Leukocyte elastase inhibitor (LEI) (Leucocyte
           neutral proteinase inhibitor) (LNPI)
          Length = 378

 Score =  161 bits (408), Expect = 2e-39
 Identities = 122/384 (31%), Positives = 189/384 (48%), Gaps = 20/384 (5%)

Query: 11  TEVALSITKHLFSKEEYQEKNLVFSPFSLHAILSVMAVGSAGSTLDELFSFLRFDSVDHL 70
           T  AL + + L   E     N+  SPFS+ + L+++ +G+ G+T  ++   L FD+V  +
Sbjct: 9   TRFALDLFRAL--NESNPAGNIFISPFSISSALAMILLGTRGNTEAQMSKALHFDTVKDI 66

Query: 71  NTFFSQVLSTVLSDTTPSFLLSFVNEMWADKSLALSHSFKQLMTTHYKATLALVDFRTKG 130
           ++ F Q L+  ++    S++L   N ++ +K+      F       Y A LA VDF    
Sbjct: 67  HSRF-QSLNADINKCGASYILKLANRLFGEKTYHFLPEFLASTQKTYGAELASVDFLRAS 125

Query: 131 DQVCREVNSWVEKETNGLITELLPTNAVHKLTKLIFANALYFKGVWKHTFDPSMTFVDDF 190
           ++  + +N WV+++T G I ELL +  V   TKL+  NA+YFKG W+  F    T    F
Sbjct: 126 EEARKAINEWVKEQTEGKIPELLASGVVDSATKLVLVNAIYFKGSWQEKFMTEATKDAPF 185

Query: 191 HLLNGTSIEVPFMSSEKKTQF--IRTFDGFNVLRLSYKQGRDKKLRFSMCIFLPNA---- 244
            L    S  V  M  +KK  F  I+      VL L Y QG+D     SM I LP++    
Sbjct: 186 RLNKKDSKTVKMMYQKKKFPFGYIKELK-CRVLELPY-QGKD----LSMVILLPDSIEDE 239

Query: 245 KDGLPSLIEKLASESCFLKGKLPRQKVRVRKFRIPKFKICFELEASNVLKELGVVSPFSK 304
             GL  + + L  E      K    ++      +P+F++    + +  L  LGV   F  
Sbjct: 240 STGLRKIEQHLTLEKLNEWTKPDNLELLEVNVHLPRFRLEESYDLNAPLARLGVQDLFG- 298

Query: 305 SNANFTKMVVSPLDELCVESIHHKASIEVNEEGTEAGVACSMCDVKLCVSARTGIDFVAD 364
           S A+ T M  S   +L +  + HKA +EVNEEGTEA  A +   + +        DF+AD
Sbjct: 299 SRADLTGM--SEARDLFISKVVHKAFVEVNEEGTEA--AAATAGIAVFAMLMPEEDFIAD 354

Query: 365 HPFLFLIREDLTGTILFIGQVLHP 388
           HPF+F IR + +  ILF+G++  P
Sbjct: 355 HPFIFFIRHNPSSNILFLGRLSSP 378


>SPB9_HUMAN (P50453) Cytoplasmic antiproteinase 3 (CAP3) (CAP-3)
           (Protease inhibitor 9) (Serpin B9)
          Length = 376

 Score =  160 bits (404), Expect = 7e-39
 Identities = 107/359 (29%), Positives = 176/359 (48%), Gaps = 10/359 (2%)

Query: 31  NLVFSPFSLHAILSVMAVGSAGSTLDELFSFLRFDSVDHLNTFFSQVLSTVLSDTTPSFL 90
           N+  SP S+ + L+++ +G+ G+T  ++   L  ++ + ++  F  +L+ V    T  +L
Sbjct: 27  NVFCSPVSISSALAMVLLGAKGNTATQMAQALSLNTEEDIHRAFQSLLTEVNKAGT-QYL 85

Query: 91  LSFVNEMWADKSLALSHSFKQLMTTHYKATLALVDFRTKGDQVCREVNSWVEKETNGLIT 150
           L   N ++ +K+     +FK+     Y A L  + F    ++  + +N+WV K+T G I 
Sbjct: 86  LRTANRLFGEKTCQFLSTFKESCLQFYHAELKELSFIRAAEESRKHINTWVSKKTEGKIE 145

Query: 151 ELLPTNAVHKLTKLIFANALYFKGVWKHTFDPSMTFVDDFHLLNGTSIEVPFMSSEKKTQ 210
           ELLP +++   T+L+  NA+YFKG W   FD + T    F +       V  M  E   +
Sbjct: 146 ELLPGSSIDAETRLVLVNAIYFKGKWNEPFDETYTREMPFKINQEEQRPVQMMYQEATFK 205

Query: 211 FIRTFD-GFNVLRLSYKQGRDKKLRFSMCIFLPNAKDGLPSLIEKLASESCFLKGKLPRQ 269
                +    +L L Y      +   S+ + LP+    L ++ + L  E      K    
Sbjct: 206 LAHVGEVRAQLLELPY-----ARKELSLLVLLPDDGVELSTVEKSLTFEKLTAWTKPDCM 260

Query: 270 KVRVRKFRIPKFKICFELEASNVLKELGVVSPFSKSNANFTKMVVSPLDELCVESIHHKA 329
           K    +  +PKFK+  + +  +VL+ LG+V  F +  A+ + M  S   +LC+    HK+
Sbjct: 261 KSTEVEVLLPKFKLQEDYDMESVLRHLGIVDAFQQGKADLSAM--SAERDLCLSKFVHKS 318

Query: 330 SIEVNEEGTEAGVACSMCDVKLCVSARTGIDFVADHPFLFLIREDLTGTILFIGQVLHP 388
            +EVNEEGTEA  A S   V  C    +G  F ADHPFLF IR +   +ILF G+   P
Sbjct: 319 FVEVNEEGTEAAAASSCFVVAEC-CMESGPRFCADHPFLFFIRHNRANSILFCGRFSSP 376


>NEUS_HUMAN (Q99574) Neuroserpin precursor (Protease inhibitor 12)
          Length = 410

 Score =  160 bits (404), Expect = 7e-39
 Identities = 114/385 (29%), Positives = 190/385 (48%), Gaps = 25/385 (6%)

Query: 15  LSITKHLFSKEEYQEKNLVFSPFSLHAILSVMAVGSAGSTLDELFSFLRFDSVDHLNTF- 73
           LS+  +   +   +++N++FSP S+   + +M +G+ GST  E+   + +DS+ +   F 
Sbjct: 29  LSVNMYNRLRATGEDENILFSPLSIALAMGMMELGAQGSTQKEIRHSMGYDSLKNGEEFS 88

Query: 74  FSQVLSTVLSDTTPSFLLSFVNEMWADKSLALSHSFKQLMTTHYKATLALVDFRTKGDQV 133
           F +  S +++     +++   N ++      ++  F Q+M  ++ A +  VDF ++   V
Sbjct: 89  FLKEFSNMVTAKESQYVMKIANSLFVQNGFHVNEEFLQMMKKYFNAAVNHVDF-SQNVAV 147

Query: 134 CREVNSWVEKETNGLITELLPTNAVHKLTKLIFANALYFKGVWKHTFDPSMTFVDDFHLL 193
              +N WVE  TN L+ +L+        T L   NA+YFKG WK  F P  T    F   
Sbjct: 148 ANYINKWVENNTNNLVKDLVSPRDFDAATYLALINAVYFKGNWKSQFRPENTRTFSFTKD 207

Query: 194 NGTSIEVPFMSSEKKTQFIRTFDGFN-------VLRLSYKQGRDKKLRFSMCIFLPNAKD 246
           + + +++P M  + +  +    DG N       VL + Y+         SM + L   + 
Sbjct: 208 DESEVQIPMMYQQGEFYYGEFSDGSNEAGGIYQVLEIPYEGD-----EISMMLVLSRQEV 262

Query: 247 GLPSLIEKLASESCFLK--GKLPRQKVRVRKFRIPKFKICFELEASNVLKELGVVSPFSK 304
            L +L E L       +    + +QKV V    +P+F +  E++  +VLK LG+   F K
Sbjct: 263 PLATL-EPLVKAQLVEEWANSVKKQKVEV---YLPRFTVEQEIDLKDVLKALGITEIFIK 318

Query: 305 SNANFTKMVVSPLDELCVESIHHKASIEVNEEGTEAGVACSMCDVKLCVSARTGIDFVAD 364
            +AN T +  S   E+ +    HK+ +EVNEEG+EA     M  + +   A      + D
Sbjct: 319 -DANLTGL--SDNKEIFLSKAIHKSFLEVNEEGSEAAAVSGM--IAISRMAVLYPQVIVD 373

Query: 365 HPFLFLIREDLTGTILFIGQVLHPE 389
           HPF FLIR   TGTILF+G+V+HPE
Sbjct: 374 HPFFFLIRNRRTGTILFMGRVMHPE 398


>ILEU_HUMAN (P30740) Leukocyte elastase inhibitor (LEI)
           (Monocyte/neutrophil elastase inhibitor) (M/NEI) (EI)
          Length = 379

 Score =  156 bits (395), Expect = 8e-38
 Identities = 114/363 (31%), Positives = 177/363 (48%), Gaps = 15/363 (4%)

Query: 31  NLVFSPFSLHAILSVMAVGSAGSTLDELFSFLRFDSVDHLNTFFSQVLSTVLSDTTPSFL 90
           N+  SPFS+ + ++++ +G+ G+T  +L     F++V+ +++ F Q L+  ++    S++
Sbjct: 27  NIFISPFSISSAMAMVFLGTRGNTAAQLSKTFHFNTVEEVHSRF-QSLNADINKRGASYI 85

Query: 91  LSFVNEMWADKSLALSHSFKQLMTTHYKATLALVDFRTKGDQVCREVNSWVEKETNGLIT 150
           L   N ++ +K+      F       Y A LA VDF+   +   + +N WV+ +T G I 
Sbjct: 86  LKLANRLYGEKTYNFLPEFLVSTQKTYGADLASVDFQHASEDARKTINQWVKGQTEGKIP 145

Query: 151 ELLPTNAVHKLTKLIFANALYFKGVWKHTFDPSMTFVDDFHLLNGTSIEVPFMSSEKKTQ 210
           ELL +  V  +TKL+  NA+YFKG WK  F    T    F L       V  M  +KK  
Sbjct: 146 ELLASGMVDNMTKLVLVNAIYFKGNWKDKFMKEATTNAPFRLNKKDRKTVKMMYQKKKFA 205

Query: 211 FIRTFD-GFNVLRLSYKQGRDKKLRFSMCIFLP----NAKDGLPSLIEKLASESCFLKGK 265
           +    D    VL L Y QG +     SM I LP    +   GL  + E+L  E      K
Sbjct: 206 YGYIEDLKCRVLELPY-QGEE----LSMVILLPDDIEDESTGLKKIEEQLTLEKLHEWTK 260

Query: 266 LPRQKVRVRKFRIPKFKICFELEASNVLKELGVVSPFSKSNANFTKMVVSPLDELCVESI 325
                       +P+FK+      ++ L  LGV   F+ S A+ + M  S   ++ +  I
Sbjct: 261 PENLDFIEVNVSLPRFKLEESYTLNSDLARLGVQDLFNSSKADLSGM--SGARDIFISKI 318

Query: 326 HHKASIEVNEEGTEAGVACSMCDVKLCVSARTGIDFVADHPFLFLIREDLTGTILFIGQV 385
            HK+ +EVNEEGTEA  A +   +          +F ADHPFLF IR + +G+ILF+G+ 
Sbjct: 319 VHKSFVEVNEEGTEA--AAATAGIATFCMLMPEENFTADHPFLFFIRHNSSGSILFLGRF 376

Query: 386 LHP 388
             P
Sbjct: 377 SSP 379


>NEUS_MOUSE (O35684) Neuroserpin precursor (Protease inhibitor 17)
          Length = 410

 Score =  155 bits (392), Expect = 2e-37
 Identities = 115/388 (29%), Positives = 192/388 (48%), Gaps = 25/388 (6%)

Query: 11  TEVALSITKHLFSKEEYQEKNLVFSPFSLHAILSVMAVGSAGSTLDELFSFLRFDSVDHL 70
           TE ++++  HL    E  ++N++FSP S+   + +M +G+ GST  E+   + ++ +   
Sbjct: 27  TEWSVNMYNHLRGTGE--DENILFSPLSIALAMGMMELGAQGSTRKEIRHSMGYEGLKGG 84

Query: 71  NTF-FSQVLSTVLSDTTPSFLLSFVNEMWADKSLALSHSFKQLMTTHYKATLALVDFRTK 129
             F F +  S + S     +++   N ++      ++  F Q++  ++ A +  VDF ++
Sbjct: 85  EEFSFLRDFSNMASAEENQYVMKLANSLFVQNGFHVNEEFLQMLKMYFNAEVNHVDF-SQ 143

Query: 130 GDQVCREVNSWVEKETNGLITELLPTNAVHKLTKLIFANALYFKGVWKHTFDPSMTFVDD 189
              V   +N WVE  TN L+ +L+       +T L   NA+YFKG WK  F P  T    
Sbjct: 144 NVAVANSINKWVENYTNSLLKDLVSPEDFDGVTNLALINAVYFKGNWKSQFRPENTRTFS 203

Query: 190 FHLLNGTSIEVPFMSSEKKTQFIRTFDGFN-------VLRLSYKQGRDKKLRFSMCIFLP 242
           F   + + +++P M  + +  +    DG N       VL + Y+         SM + L 
Sbjct: 204 FTKDDESEVQIPMMYQQGEFYYGEFSDGSNEAGGIYQVLEIPYEGD-----EISMMLALS 258

Query: 243 NAKDGLPSLIEKLASESC-FLKGKLPRQKVRVRKFRIPKFKICFELEASNVLKELGVVSP 301
             +  L +L   L ++        + +QKV V    +P+F +  E++  ++LK LGV   
Sbjct: 259 RQEVPLATLEPLLKAQLIEEWANSVKKQKVEV---YLPRFTVEQEIDLKDILKALGVTEI 315

Query: 302 FSKSNANFTKMVVSPLDELCVESIHHKASIEVNEEGTEAGVACSMCDVKLCVSARTGIDF 361
           F K +AN T M  S   EL +    HK+ IEVNEEG+EA  A  M  + +   A      
Sbjct: 316 FIK-DANLTAM--SDKKELFLSKAVHKSCIEVNEEGSEAAAASGM--IAISRMAVLYPQV 370

Query: 362 VADHPFLFLIREDLTGTILFIGQVLHPE 389
           + DHPFL+LIR   +G ILF+G+V++PE
Sbjct: 371 IVDHPFLYLIRNRKSGIILFMGRVMNPE 398


>PTI6_HUMAN (P35237) Placental thrombin inhibitor (Cytoplasmic
           antiproteinase) (CAP) (Protease inhibitor 6) (PI-6)
          Length = 376

 Score =  154 bits (388), Expect = 5e-37
 Identities = 110/364 (30%), Positives = 180/364 (49%), Gaps = 17/364 (4%)

Query: 30  KNLVFSPFSLHAILSVMAVGSAGSTLDELFSFLRFDSVDHLNTFFS--QVLSTVLSDTTP 87
           KN+ FSP S+   L+++ +G+ G+T  ++   L F+            Q L T ++ T  
Sbjct: 25  KNVFFSPMSMSCALAMVYMGAKGNTAAQMAQILSFNKSGGGGDIHQGFQSLLTEVNKTGT 84

Query: 88  SFLLSFVNEMWADKSLALSHSFKQLMTTHYKATLALVDFRTKGDQVCREVNSWVEKETNG 147
            +LL   N ++ +KS     SF+      Y+A +  +DF +  ++  + +N+WV ++T G
Sbjct: 85  QYLLRVANRLFGEKSCDFLSSFRDSCQKFYQAEMEELDFISAVEKSRKHINTWVAEKTEG 144

Query: 148 LITELLPTNAVHKLTKLIFANALYFKGVWKHTFDPSMTFVDDFHLLNGTSIEVPFMSSEK 207
            I ELL   +V  LT+L+  NA+YF+G W   FD   T    F +    + E P     K
Sbjct: 145 KIAELLSPGSVDPLTRLVLVNAVYFRGNWDEQFDKENTEERLFKV--SKNEEKPVQMMFK 202

Query: 208 KTQFIRTFDG---FNVLRLSYKQGRDKKLRFSMCIFLPNAKDGLPSLIEKLASESCFLKG 264
           ++ F +T+ G     +L L Y  G++     +M I LP+    L ++ ++L  E      
Sbjct: 203 QSTFKKTYIGEIFTQILVLPY-VGKE----LNMIIMLPDETTDLRTVEKELTYEKFVEWT 257

Query: 265 KLPRQKVRVRKFRIPKFKICFELEASNVLKELGVVSPFSKSNANFTKMVVSPLDELCVES 324
           +L        +  +P+FK+    +  +VL+ LG+   F    A+F+ M  +   +L +  
Sbjct: 258 RLDMMDEEEVEVSLPRFKLEESYDMESVLRNLGMTDAFELGKADFSGMSQT---DLSLSK 314

Query: 325 IHHKASIEVNEEGTEAGVACSMCDVKLCVSARTGIDFVADHPFLFLIREDLTGTILFIGQ 384
           + HK+ +EVNEEGTEA  A +   +  C  AR    F ADHPFLF I+   T  ILF G+
Sbjct: 315 VVHKSFVEVNEEGTEAAAATAAIMMMRC--ARFVPRFCADHPFLFFIQHSKTNGILFCGR 372

Query: 385 VLHP 388
              P
Sbjct: 373 FSSP 376


>PAI1_RAT (P20961) Plasminogen activator inhibitor-1 precursor
           (PAI-1) (Endothelial plasminogen activator inhibitor)
           (PAI)
          Length = 402

 Score =  153 bits (386), Expect = 9e-37
 Identities = 113/383 (29%), Positives = 193/383 (49%), Gaps = 21/383 (5%)

Query: 11  TEVALSITKHLFSKEEYQEKNLVFSPFSLHAILSVMAVGSAGSTLDELFSFLRFDSVDHL 70
           T   + + +H+    +  ++N+VFSP+ + ++L+++ + +AG T  ++   + F+  +  
Sbjct: 36  TNFGVKVFQHVVQASK--DRNVVFSPYGVSSVLAMLQLTTAGKTRQQIQDAMGFNISERG 93

Query: 71  NTFFSQVLSTVLSDTTPSFLLSFVNEMWADKSLALSHSFKQLMTTHYKATLALVDFRTKG 130
                + LS  L  +     +S  + ++  + L L   F       ++ T+  VDF ++ 
Sbjct: 94  TAPALRKLSKELMGSWNKNEISTADAIFVQRDLELVQGFMPHFFKLFRTTVKQVDF-SEV 152

Query: 131 DQVCREVNSWVEKETNGLITELLPTNAVHKLTKLIFANALYFKGVWKHTFDPSMTFVDDF 190
           ++    +N WVE+ T G+I++LL   AV++LT+L+  NALYF G WK  F  + T    F
Sbjct: 153 ERARFIINDWVERHTKGMISDLLAKGAVNELTRLVLVNALYFNGQWKTPFLEASTHQRLF 212

Query: 191 HLLNGTSIEVPFMSSEKKTQF--IRTFDG--FNVLRLSYKQGRDKKLRFSMCIFLPNAKD 246
           H  +G++I VP M+   K  +    T DG  +++L L Y          SM I  P  KD
Sbjct: 213 HKSDGSTISVPMMAQNNKFNYTEFTTPDGHEYDILELPYHGE-----TLSMFIAAPFEKD 267

Query: 247 GLPSLIEKLASESCFLKGKLPRQKVRVRKFRIPKFKICFELEASNVLKELGVVSPFSKSN 306
              S I  +       + K    ++  R   +PKF +  E++    L++LG+   FS + 
Sbjct: 268 VPLSAITNILDAELIRQWKSNMTRL-PRLLILPKFSLETEVDLRGPLEKLGMTDIFSSTQ 326

Query: 307 ANFTKMVVSPLDELCVESIHHKASIEVNEEGTEAGVACSMCDVKLCVSARTG-IDFVADH 365
           A+FT +  S  ++L V     K  IEVNE GT A  + +     + VSAR    + V D 
Sbjct: 327 ADFTSL--SDQEQLSVAQALQKVKIEVNESGTVASSSTA-----ILVSARMAPTEMVLDR 379

Query: 366 PFLFLIREDLTGTILFIGQVLHP 388
            FLF++R + T TILF+GQ++ P
Sbjct: 380 SFLFVVRHNPTETILFMGQLMEP 402


>SCC1_HUMAN (P29508) Squamous cell carcinoma antigen 1 (SCCA-1)
           (Protein T4-A)
          Length = 390

 Score =  152 bits (385), Expect = 1e-36
 Identities = 107/377 (28%), Positives = 178/377 (46%), Gaps = 25/377 (6%)

Query: 28  QEKNLVFSPFSLHAILSVMAVGSAGSTLDELFSFLRFDSVDHLNTFFS------------ 75
           +E N+ +SP S+ + L ++ +G+  +T  ++   L FD V    T  +            
Sbjct: 23  KENNIFYSPISITSALGMVLLGAKDNTAQQIKKVLHFDQVTENTTGKAATYHVDRSGNVH 82

Query: 76  ---QVLSTVLSDTTPSFLLSFVNEMWADKSLALSHSFKQLMTTHYKATLALVDFRTKGDQ 132
              Q L T  + +T ++ L   N+++ +K+      +   +   Y+ ++  VDF    ++
Sbjct: 83  HQFQKLLTEFNKSTDAYELKIANKLFGEKTYLFLQEYLDAIKKFYQTSVESVDFANAPEE 142

Query: 133 VCREVNSWVEKETNGLITELLPTNAVHKLTKLIFANALYFKGVWKHTFDPSMTFVDDFHL 192
             +++NSWVE +TN  I  L+P   +   T L+  NA+YFKG W+  F+   T  + F  
Sbjct: 143 SRKKINSWVESQTNEKIKNLIPEGNIGSNTTLVLVNAIYFKGQWEKKFNKEDTKEEKFWP 202

Query: 193 LNGTSIEVPFMSSEKKTQFIRTFD-GFNVLRLSYKQGRDKKLRFSMCIFLPNAKDGLPSL 251
              T   +  M       F    D    VL + YK G+D     SM + LPN  DGL  L
Sbjct: 203 NKNTYKSIQMMRQYTSFHFASLEDVQAKVLEIPYK-GKD----LSMIVLLPNEIDGLQKL 257

Query: 252 IEKLASESCFLKGKLPRQKVRVRKFRIPKFKICFELEASNVLKELGVVSPFSKSNANFTK 311
            EKL +E       L   +       +P+FK+    +  + L+ +G+V  F+  +A+ + 
Sbjct: 258 EEKLTAEKLMEWTSLQNMRETRVDLHLPRFKVEESYDLKDTLRTMGMVDIFN-GDADLSG 316

Query: 312 MVVSPLDELCVESIHHKASIEVNEEGTEAGVACSMCDVKLCVSARTGIDFVADHPFLFLI 371
           M  S    L +  + HKA +EV EEG EA  A ++       ++ T  +F  +HPFLF I
Sbjct: 317 MTGS--RGLVLSGVLHKAFVEVTEEGAEAAAATAVVGFGSSPTS-TNEEFHCNHPFLFFI 373

Query: 372 REDLTGTILFIGQVLHP 388
           R++ T +ILF G+   P
Sbjct: 374 RQNKTNSILFYGRFSSP 390


>SPB8_HUMAN (P50452) Cytoplasmic antiproteinase 2 (CAP2) (CAP-2)
           (Protease inhibitor 8) (Serpin B8)
          Length = 374

 Score =  152 bits (384), Expect = 1e-36
 Identities = 117/385 (30%), Positives = 182/385 (46%), Gaps = 20/385 (5%)

Query: 9   CQTEVALSITKHLFSKEEYQEKNLVFSPFSLHAILSVMAVGSAGSTLDELFSFLRFDSVD 68
           C+     +I+      EE   +N+ FSP S+ + L+++ +G+ GST  ++   L      
Sbjct: 5   CEANGTFAISLFKILGEEDNSRNVFFSPMSISSALAMVFMGAKGSTAAQMSQALCLYKDG 64

Query: 69  HLNTFFSQVLSTVLSDTTPSFLLSFVNEMWADKSLALSHSFKQLMTTHYKATLALVDFRT 128
            ++  F  +LS V + T   +LL   N ++ +K+      FK+     Y+A L  + F  
Sbjct: 65  DIHRGFQSLLSEV-NRTGTQYLLRTANRLFGEKTCDFLPDFKEYCQKFYQAELEELSFAE 123

Query: 129 KGDQVCREVNSWVEKETNGLITELLPTNAVHKLTKLIFANALYFKGVWKHTFDPSMTFVD 188
             ++  + +N WV ++T G I+E+L    V  LTKL+  NA+YFKG W   FD   T   
Sbjct: 124 DTEECRKHINDWVAEKTEGKISEVLDAGTVDPLTKLVLVNAIYFKGKWNEQFDRKYTRGM 183

Query: 189 DFHLLNGTSIEVPFMSSEKKTQFIRTFD-GFNVLRLSYKQGRDKKLRFSMCIFLPNAKDG 247
            F   N     V  M  E K +     +    VL L Y +        SM I LP+    
Sbjct: 184 LFK-TNEEKKTVQMMFKEAKFKMGYADEVHTQVLELPYVEE-----ELSMVILLPDDNTD 237

Query: 248 LPSLIEKLASESCFL----KGKLPRQKVRVRKFRIPKFKICFELEASNVLKELGVVSPFS 303
           L +++EK  +   F       KL + KV+V    +P+ K+    +    L+ LG++  F 
Sbjct: 238 L-AVVEKALTYEKFKAWTNSEKLTKSKVQV---FLPRLKLEESYDLEPFLRRLGMIDAFD 293

Query: 304 KSNANFTKMVVSPLDELCVESIHHKASIEVNEEGTEAGVACSMCDVKLCVSARTGIDFVA 363
           ++ A+F+ M  S    + +  + HK  +EVNEEGTEA  A ++     C  +R    F A
Sbjct: 294 EAKADFSGM--STEKNVPLSKVAHKCFVEVNEEGTEAAAATAVVRNSRC--SRMEPRFCA 349

Query: 364 DHPFLFLIREDLTGTILFIGQVLHP 388
           DHPFLF IR   T  ILF G+   P
Sbjct: 350 DHPFLFFIRRHKTNCILFCGRFSSP 374


>PAI1_MUSVI (P50449) Plasminogen activator inhibitor-1 precursor
           (PAI-1) (Endothelial plasminogen activator inhibitor)
           (PAI)
          Length = 400

 Score =  152 bits (383), Expect = 2e-36
 Identities = 111/373 (29%), Positives = 186/373 (49%), Gaps = 33/373 (8%)

Query: 28  QEKNLVFSPFSLHAILSVMAVGSAGSTLDELFSFLRFDSVDH-----LNTFFSQVLSTVL 82
           +++N+VFSP+ L ++L+++ + +AG T  ++   +RF   +      L   + +++    
Sbjct: 49  KDRNMVFSPYGLASVLAMLQLTTAGETRQQIQEAMRFQIDEKGMAPALRQLYKELMGPWN 108

Query: 83  SDTTPSFLLSFVNEMWADKSLALSHSFKQLMTTHYKATLALVDFRTKGDQVCREVNSWVE 142
            D      +S  + ++  + L L H F       ++ T+  VDF ++ ++    +N WV+
Sbjct: 109 KDE-----ISTADAIFVQRDLKLVHGFMPYFFRLFQTTVKQVDF-SEVERARFIINDWVK 162

Query: 143 KETNGLITELLPTNAVHKLTKLIFANALYFKGVWKHTFDPSMTFVDDFHLLNGTSIEVPF 202
           + T G+I +LL    V +LT+L+  NALYF G WK  F  S T    FH  +G+++ VP 
Sbjct: 163 RHTKGMIGDLLGRGTVDQLTRLMLVNALYFNGQWKTPFPKSGTHHRLFHKSDGSTVSVPM 222

Query: 203 MSSEKKTQF--IRTFDG--FNVLRLSYKQGRDKKLRFSMCIFLPNAKDGLPSLIEKLASE 258
           M+   K  +    T +G  +++L L Y          SM I  P  KD   S +  +   
Sbjct: 223 MAQTNKFNYTEFSTPEGRYYDILELPYHGD-----TLSMFIAAPYEKDVPLSALTNILDA 277

Query: 259 SCF--LKGKLPRQKVRVRKFRIPKFKICFELEASNVLKELGVVSPFSKSNANFTKMVVSP 316
                 KG + R   R+R   +PKF +  E+     L+ LG+   F  + A+F+ +  S 
Sbjct: 278 QLISQWKGNMTR---RLRLLVLPKFSLESEVNLRGPLENLGMTDMFRPNQADFSSL--SD 332

Query: 317 LDELCVESIHHKASIEVNEEGTEAGVACSMCDVKLCVSARTG-IDFVADHPFLFLIREDL 375
            + L V     K  IEVNE GT A  + +     + VSAR    + + D PFLF++R + 
Sbjct: 333 QEALYVSQALQKVKIEVNESGTVASSSTA-----IIVSARMAPEEIIMDRPFLFVVRHNP 387

Query: 376 TGTILFIGQVLHP 388
           TGT+LF+GQV+ P
Sbjct: 388 TGTVLFMGQVMEP 400


  Database: sprot
    Posted date:  Nov 25, 2004 10:54 AM
  Number of letters in database: 59,974,054
  Number of sequences in database:  164,201
  
Lambda     K      H
   0.323    0.136    0.397 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 44,391,215
Number of Sequences: 164201
Number of extensions: 1802831
Number of successful extensions: 4537
Number of sequences better than 10.0: 153
Number of HSP's better than 10.0 without gapping: 135
Number of HSP's successfully gapped in prelim test: 18
Number of HSP's that attempted gapping in prelim test: 3880
Number of HSP's gapped (non-prelim): 165
length of query: 402
length of database: 59,974,054
effective HSP length: 112
effective length of query: 290
effective length of database: 41,583,542
effective search space: 12059227180
effective search space used: 12059227180
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 67 (30.4 bits)