BLASTP 2.2.2 [Dec-14-2001]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= TM0135.9
         (645 letters)

Database: sprot 
           164,201 sequences; 59,974,054 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

MSP1_YEAST (P28737) MSP1 protein (TAT-binding homolog 4)              246  1e-64
SPAS_MOUSE (Q9QYY8) Spastin                                           238  3e-62
SPAS_HUMAN (Q9UBP0) Spastin                                           238  4e-62
SAP1_YEAST (P39955) SAP1 protein                                      227  8e-59
TBP6_YEAST (P40328) Probable 26S protease subunit YTA6 (TAT-bind...   211  4e-54
MEI1_CAEEL (P34808) Meiotic spindle formation protein mei-1           206  2e-52
SKD1_SCHPO (Q09803) Suppressor protein of bem1/bed5 double mutants    201  4e-51
YC97_ARCFU (O28972) Cell division cycle protein 48 homolog AF1297     199  2e-50
MSP1_CAEEL (P54815) MSP1 protein homolog                              198  3e-50
VAT_THEAC (O05209) VCP-like ATPase                                    196  2e-49
SKD1_MOUSE (P46467) SKD1 protein (Vacuolar sorting protein 4b)        190  9e-48
VPS4_YEAST (P52917) Vacuolar protein sorting-associated protein ...   190  1e-47
TERA_XENLA (P23787) Transitional endoplasmic reticulum ATPase (T...   187  1e-46
TERA_RAT (P46462) Transitional endoplasmic reticulum ATPase (TER...   186  2e-46
TERA_MOUSE (Q01853) Transitional endoplasmic reticulum ATPase (T...   186  2e-46
TERA_HUMAN (P55072) Transitional endoplasmic reticulum ATPase (T...   186  2e-46
SKD1_HUMAN (O75351) SKD1 protein (Vacuolar sorting protein 4b)        186  2e-46
YB56_METJA (Q58556) Cell division cycle protein 48 homolog MJ1156     184  5e-46
TERA_PIG (P03974) Transitional endoplasmic reticulum ATPase (TER...   184  5e-46
CC48_YEAST (P25694) Cell division control protein 48                  183  1e-45

>MSP1_YEAST (P28737) MSP1 protein (TAT-binding homolog 4)
          Length = 362

 Score =  246 bits (629), Expect = 1e-64
 Identities = 140/330 (42%), Positives = 205/330 (61%), Gaps = 16/330 (4%)

Query: 281 HYLSSCLLPCVKGDKLC-LPRESLEIAISRLKGVETMSRQPSQSLKNLAKDEFESNFISA 339
           +YL S LL  V+   L    RES   A   L+  + + R P+  L  +  D +E   +S+
Sbjct: 24  YYLVSRLLNDVESGPLSGKSRESK--AKQSLQWEKLVKRSPA--LAEVTLDAYERTILSS 79

Query: 340 VVPPGEIGVKFDDIGALEDVKKALNELVILPMRRPELFTHGNLLRPVKGILLFGPPGTGK 399
           +V P EI + F DIG L+ +   L+E VI P+  PE++++  LL+   G+LL+GPPG GK
Sbjct: 80  IVTPDEINITFQDIGGLDPLISDLHESVIYPLMMPEVYSNSPLLQAPSGVLLYGPPGCGK 139

Query: 400 TLMAKALATEAGANFISVSGSTLTSKWFGDAEKLTKALFSFASKLAPVIIFVDEVDSLLG 459
           T++AKALA E+GANFIS+  S++  KW+G++ K+  A+FS A+KL P IIF+DE+DS L 
Sbjct: 140 TMLAKALAKESGANFISIRMSSIMDKWYGESNKIVDAMFSLANKLQPCIIFIDEIDSFLR 199

Query: 460 ARGGAFEHEATRRMRNEFMAAWDGLRSKENQRILILGATNRPFDLDDAVIRRLPRRIYVD 519
            R    +HE T  ++ EFM  WDGL +  N R++I+GATNR  D+DDA +RRLP+R  V 
Sbjct: 200 ERSST-DHEVTATLKAEFMTLWDGLLN--NGRVMIIGATNRINDIDDAFLRRLPKRFLVS 256

Query: 520 LPDADNRKKILRIILKHENLDPD-FQFDKLANLTDGYSGSDLKNLCITAAYRPVQELLEE 578
           LP +D R KIL ++LK   LD D F    +A+ T G+SGSDLK LC  AA    +E +++
Sbjct: 257 LPGSDQRYKILSVLLKDTKLDEDEFDLQLIADNTKGFSGSDLKELCREAALDAAKEYIKQ 316

Query: 579 EK-------AGDNNITNVALRPLNLDDFVQ 601
           ++          N+ +++ +RPL   DF +
Sbjct: 317 KRQLIDSGTIDVNDTSSLKIRPLKTKDFTK 346


>SPAS_MOUSE (Q9QYY8) Spastin
          Length = 614

 Score =  238 bits (608), Expect = 3e-62
 Identities = 136/317 (42%), Positives = 202/317 (62%), Gaps = 10/317 (3%)

Query: 315 TMSRQPSQSLKNLAK-DEFESNFISAVVPPGEIGVKFDDIGALEDVKKALNELVILPMRR 373
           T + +  + LKN    D   +N I   +      VKFDDI   E  K+AL E+VILP  R
Sbjct: 303 TTAVRKKKDLKNFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQELAKQALQEIVILPSLR 362

Query: 374 PELFTHGNLLRPVKGILLFGPPGTGKTLMAKALATEAGANFISVSGSTLTSKWFGDAEKL 433
           PELFT   L  P +G+LLFGPPG GKT++AKA+A E+ A F ++S ++LTSK+ G+ EKL
Sbjct: 363 PELFT--GLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKL 420

Query: 434 TKALFSFASKLAPVIIFVDEVDSLLGARGGAFEHEATRRMRNEFMAAWDGLRSKENQRIL 493
            +ALF+ A +L P IIF+DEVDSLL  R    EH+A+RR++ EF+  +DG++S  + R+L
Sbjct: 421 VRALFAVARELQPSIIFIDEVDSLLCERREG-EHDASRRLKTEFLIEFDGVQSAGDDRVL 479

Query: 494 ILGATNRPFDLDDAVIRRLPRRIYVDLPDADNRKKILR-IILKHENLDPDFQFDKLANLT 552
           ++GATNRP +LD+AV+RR  +R+YV LP+ + R  +L+ ++ K  +     +  +LA +T
Sbjct: 480 VMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARMT 539

Query: 553 DGYSGSDLKNLCITAAYRPVQELLEEEKAGDNNITNVALRPLNLDDFVQSKSKVGPSVAY 612
           DGYSGSDL  L   AA  P++EL  E+     N++   +R + L DF +S  K+  SV+ 
Sbjct: 540 DGYSGSDLTALAKDAALGPIRELKPEQV---KNMSASEMRNIRLSDFTESLKKIKRSVS- 595

Query: 613 DAVSVNELRKWNEMYGE 629
              ++    +WN+ +G+
Sbjct: 596 -PQTLEAYIRWNKDFGD 611


>SPAS_HUMAN (Q9UBP0) Spastin
          Length = 616

 Score =  238 bits (607), Expect = 4e-62
 Identities = 135/317 (42%), Positives = 202/317 (63%), Gaps = 10/317 (3%)

Query: 315 TMSRQPSQSLKNLAK-DEFESNFISAVVPPGEIGVKFDDIGALEDVKKALNELVILPMRR 373
           T + +  + LKN    D   +N I   +      VKFDDI   +  K+AL E+VILP  R
Sbjct: 305 TTATRKKKDLKNFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLR 364

Query: 374 PELFTHGNLLRPVKGILLFGPPGTGKTLMAKALATEAGANFISVSGSTLTSKWFGDAEKL 433
           PELFT   L  P +G+LLFGPPG GKT++AKA+A E+ A F ++S ++LTSK+ G+ EKL
Sbjct: 365 PELFT--GLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKL 422

Query: 434 TKALFSFASKLAPVIIFVDEVDSLLGARGGAFEHEATRRMRNEFMAAWDGLRSKENQRIL 493
            +ALF+ A +L P IIF+DEVDSLL  R    EH+A+RR++ EF+  +DG++S  + R+L
Sbjct: 423 VRALFAVARELQPSIIFIDEVDSLLCERREG-EHDASRRLKTEFLIEFDGVQSAGDDRVL 481

Query: 494 ILGATNRPFDLDDAVIRRLPRRIYVDLPDADNRKKILR-IILKHENLDPDFQFDKLANLT 552
           ++GATNRP +LD+AV+RR  +R+YV LP+ + R  +L+ ++ K  +     +  +LA +T
Sbjct: 482 VMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARMT 541

Query: 553 DGYSGSDLKNLCITAAYRPVQELLEEEKAGDNNITNVALRPLNLDDFVQSKSKVGPSVAY 612
           DGYSGSDL  L   AA  P++EL  E+     N++   +R + L DF +S  K+  SV+ 
Sbjct: 542 DGYSGSDLTALAKDAALGPIRELKPEQV---KNMSASEMRNIRLSDFTESLKKIKRSVS- 597

Query: 613 DAVSVNELRKWNEMYGE 629
              ++    +WN+ +G+
Sbjct: 598 -PQTLEAYIRWNKDFGD 613


>SAP1_YEAST (P39955) SAP1 protein
          Length = 897

 Score =  227 bits (578), Expect = 8e-59
 Identities = 138/356 (38%), Positives = 206/356 (57%), Gaps = 39/356 (10%)

Query: 300 RESLEIAISRLKGVETMSRQPSQSLKNLAKDEFESNFISAVVPPGEIGVKFDDIGALEDV 359
           RE  EI    L+  E +  +   SL+ + +   +  F   VV   E  V +DDI  LE  
Sbjct: 558 REEPEIDKKVLR--EILEDEIIDSLQGVDRQAAKQIFAEIVVHGDE--VHWDDIAGLESA 613

Query: 360 KKALNELVILPMRRPELFTHGNLLRPVKGILLFGPPGTGKTLMAKALATEAGANFISVSG 419
           K +L E V+ P  RP+LF    L  PV+G+LLFGPPGTGKT++A+A+ATE+ + F S+S 
Sbjct: 614 KYSLKEAVVYPFLRPDLFR--GLREPVRGMLLFGPPGTGKTMLARAVATESHSTFFSISA 671

Query: 420 STLTSKWFGDAEKLTKALFSFASKLAPVIIFVDEVDSLLGARGGAFEHEATRRMRNEFMA 479
           S+LTSK+ G++EKL +ALF+ A KL+P IIFVDE+DS++G+R    E+E++RR++NEF+ 
Sbjct: 672 SSLTSKYLGESEKLVRALFAIAKKLSPSIIFVDEIDSIMGSRNNENENESSRRIKNEFLV 731

Query: 480 AWDGLRS------------------KENQRILILGATNRPFDLDDAVIRRLPRRIYVDLP 521
            W  L S                  +++ R+L+L ATN P+ +D+A  RR  RR Y+ LP
Sbjct: 732 QWSSLSSAAAGSNKSNTNNSDTNGDEDDTRVLVLAATNLPWSIDEAARRRFVRRQYIPLP 791

Query: 522 DADNRKKILRIILKHE-NLDPDFQFDKLANLTDGYSGSDLKNLCITAAYRPVQE----LL 576
           +   R    + +L H+ +   +  FD+L  +T+GYSGSD+ +L   AA  P+++    LL
Sbjct: 792 EDQTRHVQFKKLLSHQKHTLTESDFDELVKITEGYSGSDITSLAKDAAMGPLRDLGDKLL 851

Query: 577 EEEKAGDNNITNVALRPLNLDDFVQSKSKVGPSVAYDAVSVNELRKWNEMYGEGGT 632
           E E+          +RP+ L DF  S   + PSV+ D +   E  KW   +G  G+
Sbjct: 852 ETERE--------MIRPIGLVDFKNSLVYIKPSVSQDGLVKYE--KWASQFGSSGS 897


>TBP6_YEAST (P40328) Probable 26S protease subunit YTA6 (TAT-binding
           homolog 6)
          Length = 754

 Score =  211 bits (538), Expect = 4e-54
 Identities = 117/296 (39%), Positives = 183/296 (61%), Gaps = 20/296 (6%)

Query: 348 VKFDDIGALEDVKKALNELVILPMRRPELFTHGNLLRPVKGILLFGPPGTGKTLMAKALA 407
           V ++DI  L + K +L E V+ P  RP+LF    L  PV+G+LLFGPPGTGKT++AKA+A
Sbjct: 468 VYWEDIAGLRNAKNSLKEAVVYPFLRPDLFK--GLREPVRGMLLFGPPGTGKTMIAKAVA 525

Query: 408 TEAGANFISVSGSTLTSKWFGDAEKLTKALFSFASKLAPVIIFVDEVDSLLGARGGAFEH 467
           TE+ + F SVS S+L SK+ G++EKL +ALF  A KL+P IIF+DE+DS+L AR    E+
Sbjct: 526 TESNSTFFSVSASSLLSKYLGESEKLVRALFYMAKKLSPSIIFIDEIDSMLTARSDN-EN 584

Query: 468 EATRRMRNEFMAAWDGLRSKENQ----------RILILGATNRPFDLDDAVIRRLPRRIY 517
           E++RR++ E +  W  L S   Q          R+L+LGATN P+ +DDA  RR  R++Y
Sbjct: 585 ESSRRIKTELLIQWSSLSSATAQSEDRNNTLDSRVLVLGATNLPWAIDDAARRRFSRKLY 644

Query: 518 VDLPDADNR-KKILRIILKHENLDPDFQFDKLANLTDGYSGSDLKNLCITAAYRPVQELL 576
           + LPD + R   + R++ K +N   D  ++ +  +T+G+SGSDL +L   AA  P+++L 
Sbjct: 645 IPLPDYETRLYHLKRLMAKQKNSLQDLDYELITEMTEGFSGSDLTSLAKEAAMEPIRDLG 704

Query: 577 EEEKAGDNNITNVALRPLNLDDFVQSKSKVGPSVAYDAVSVNELRKWNEMYGEGGT 632
           ++    D +     +R + + DF  +   +  SV+ +  S+ +  +W+  +G  G+
Sbjct: 705 DKLMFADFD----KIRGIEIKDFQNALLTIKKSVSSE--SLQKYEEWSSKFGSNGS 754


>MEI1_CAEEL (P34808) Meiotic spindle formation protein mei-1
          Length = 472

 Score =  206 bits (524), Expect = 2e-52
 Identities = 120/326 (36%), Positives = 194/326 (58%), Gaps = 23/326 (7%)

Query: 320 PSQSL--KNLAKDEFESNFISAVVPPGEIG---------VKFDDIGALEDVKKALNELVI 368
           P+Q +  +N A D F+++   A +     G         +  DDI  + DVK+ L+E V 
Sbjct: 151 PTQGILPQNSAGDSFDASAYDAYIVQAVRGTMATNTENTMSLDDIIGMHDVKQVLHEAVT 210

Query: 369 LPMRRPELFTHGNLLRPVKGILLFGPPGTGKTLMAKALATEAGANFISVSGSTLTSKWFG 428
           LP+  PE F    L  P K ++L GPPGTGKTL+A+A+A+E+ + F +VS + L+SKW G
Sbjct: 211 LPLLVPEFFQ--GLRSPWKAMVLAGPPGTGKTLIARAIASESSSTFFTVSSTDLSSKWRG 268

Query: 429 DAEKLTKALFSFASKLAPVIIFVDEVDSLLGARGGAFEHEATRRMRNEFMAAWDGLRSK- 487
           D+EK+ + LF  A   AP IIF+DE+D+L G RG + EHEA+RR+++EF+   DG ++K 
Sbjct: 269 DSEKIVRLLFELARFYAPSIIFIDEIDTLGGQRGNSGEHEASRRVKSEFLVQMDGSQNKF 328

Query: 488 ENQRILILGATNRPFDLDDAVIRRLPRRIYVDLPDADNRKKILRIILKHENLDPDFQFDK 547
           +++R+ +L ATN P++LD+A+ RR  +RI++ LPD D RKK++   ++      +  +D 
Sbjct: 329 DSRRVFVLAATNIPWELDEALRRRFEKRIFIPLPDIDARKKLIEKSMEGTPKSDEINYDD 388

Query: 548 LANLTDGYSGSDLKNLCITAAYRPVQELLEEEKAGDNNITNVALRPLNLD-----DFVQS 602
           LA  T+G+SG+D+ +LC TAA   ++    + K+        A+  L  +     DF  +
Sbjct: 389 LAARTEGFSGADVVSLCRTAAINVLRRY--DTKSLRGGELTAAMESLKAELVRNIDFEAA 446

Query: 603 KSKVGPSVAYDAVSVNELRKWNEMYG 628
              V PS   D  ++ + ++W + +G
Sbjct: 447 LQAVSPSAGPD--TMLKCKEWCDSFG 470


>SKD1_SCHPO (Q09803) Suppressor protein of bem1/bed5 double mutants
          Length = 432

 Score =  201 bits (512), Expect = 4e-51
 Identities = 105/229 (45%), Positives = 155/229 (66%), Gaps = 5/229 (2%)

Query: 348 VKFDDIGALEDVKKALNELVILPMRRPELFTHGNLLRPVKGILLFGPPGTGKTLMAKALA 407
           V++DDI  LE+ K+AL E V+LP++ P+LF+HG   +P  GILL+GPPGTGK+ +AKA+A
Sbjct: 126 VRWDDIAGLENAKEALKETVLLPIKLPQLFSHGR--KPWSGILLYGPPGTGKSYLAKAVA 183

Query: 408 TEAGANFISVSGSTLTSKWFGDAEKLTKALFSFASKLAPVIIFVDEVDSLLGARGGAFEH 467
           TEAG+ F S+S S L SKW G++E+L + LF  A +  P IIF+DE+DSL G+R    E 
Sbjct: 184 TEAGSTFFSISSSDLVSKWMGESERLVRQLFEMAREQKPSIIFIDEIDSLCGSRSEG-ES 242

Query: 468 EATRRMRNEFMAAWDGLRSKENQRILILGATNRPFDLDDAVIRRLPRRIYVDLPDADNRK 527
           E++RR++ EF+   +G+  K+   +L+LGATN P+ LD A+ RR  +RIY+ LP+A  R 
Sbjct: 243 ESSRRIKTEFLVQMNGV-GKDESGVLVLGATNIPWTLDSAIRRRFEKRIYIPLPNAHARA 301

Query: 528 KILRI-ILKHENLDPDFQFDKLANLTDGYSGSDLKNLCITAAYRPVQEL 575
           ++  + + K  +      F +LA +TDGYSGSD+  +   A   PV+ +
Sbjct: 302 RMFELNVGKIPSELTSQDFKELAKMTDGYSGSDISIVVRDAIMEPVRRI 350


>YC97_ARCFU (O28972) Cell division cycle protein 48 homolog AF1297
          Length = 733

 Score =  199 bits (506), Expect = 2e-50
 Identities = 134/406 (33%), Positives = 215/406 (52%), Gaps = 22/406 (5%)

Query: 229 DRKIVISRSNLNELRKVLEEHQLSCVDLLHLDSDDVILTKQKAEKVVGWAKNHYLSSCLL 288
           DR+I I   +    +++LE H         +D +++      AE   G+      + C  
Sbjct: 342 DREIEIGVPDKEGRKEILEIHTRKMPLAEDVDLEEL------AELTNGFVGADLEALCKE 395

Query: 289 PCVKGDKLCLPR---ESLEIAISRLKGVETMSRQPSQSLKNLAKDEFESNFISAVVPPGE 345
             +   +  LP    E+ EI    ++ ++       ++LKN+         +   VP   
Sbjct: 396 AAMHALRRVLPEIDIEAEEIPAEVIENLKVTREDFMEALKNIEPSAMREVLVE--VP--- 450

Query: 346 IGVKFDDIGALEDVKKALNELVILPMRRPELFTHGNLLRPVKGILLFGPPGTGKTLMAKA 405
             VK++DIG LE  K+ L E V  P++ PE+F   N+ +P +GILLFGPPGTGKTL+AKA
Sbjct: 451 -NVKWEDIGGLEHAKQELMEAVEWPLKYPEVFRAANI-KPPRGILLFGPPGTGKTLLAKA 508

Query: 406 LATEAGANFISVSGSTLTSKWFGDAEKLTKALFSFASKLAPVIIFVDEVDSLLGARGGAF 465
           +A E+ ANFISV G  L SKW G++EK  + +F  A ++AP +IF DE+DSL   RGG  
Sbjct: 509 VANESNANFISVKGPELLSKWVGESEKHVREMFRKARQVAPCVIFFDEIDSLAPRRGGIG 568

Query: 466 EHEATRRMRNEFMAAWDGLRSKENQRILILGATNRPFDLDDAVIR--RLPRRIYVDLPDA 523
           +   T R+ ++ +   DGL  +E + ++++ ATNRP  +D A++R  RL R IY+  PD 
Sbjct: 569 DSHVTERVVSQLLTELDGL--EELKDVVVIAATNRPDMIDPALLRPGRLERHIYIPPPDK 626

Query: 524 DNRKKILRIILKHENLDPDFQFDKLANLTDGYSGSDLKNLCITAAYRPVQELLEEEKAGD 583
             R +I +I L+ + L  D   ++LA  T+GYSG+D++ +C  A    ++EL++     +
Sbjct: 627 KARVEIFKIHLRGKPLADDVNIEELAEKTEGYSGADIEAVCREAGMLAIRELIKPGMTRE 686

Query: 584 NNITNVALRPLNLDDFVQSKSKVGPSVAYDAVSVNE--LRKWNEMY 627
                     +    F ++  KV PS+  + V   E  +  ++ MY
Sbjct: 687 EAKEAAKKLKITKKHFEEALKKVRPSLTKEDVEKYEKLIEDFHRMY 732



 Score =  181 bits (459), Expect = 5e-45
 Identities = 116/348 (33%), Positives = 191/348 (54%), Gaps = 21/348 (6%)

Query: 289 PCVKGDKLCLP----RESLEIAISRLKGVETMSRQPSQSLKNLAKDEFESNFISAVVPPG 344
           P +KG K+ +       +  I  +R  GV  ++R  +  LK    +E     +   VP  
Sbjct: 125 PVIKGQKIRVEVFGHTLTFVITATRPSGVVVVTRNTAIELKEKPAEE-----VKRAVPD- 178

Query: 345 EIGVKFDDIGALEDVKKALNELVILPMRRPELFTHGNLLRPVKGILLFGPPGTGKTLMAK 404
              V ++DIG L+   + + E++ LP++ PELF    +  P KG+LL+GPPGTGKTL+AK
Sbjct: 179 ---VTYEDIGGLKRELRLVREMIELPLKHPELFQRLGI-EPPKGVLLYGPPGTGKTLIAK 234

Query: 405 ALATEAGANFISVSGSTLTSKWFGDAEKLTKALFSFASKLAPVIIFVDEVDSLLGARGGA 464
           A+A E  A+FI +SG  + SK++G++E+  + +F  A + AP IIF+DE+DS+   R   
Sbjct: 235 AVANEVDAHFIPISGPEIMSKYYGESEQRLREIFEEAKENAPSIIFIDEIDSIAPKR-EE 293

Query: 465 FEHEATRRMRNEFMAAWDGLRSKENQRILILGATNRPFDLDDAVIR--RLPRRIYVDLPD 522
              E  RR+  + +A  DGL ++ +  ++++ ATNRP  +D A+ R  R  R I + +PD
Sbjct: 294 VTGEVERRVVAQLLALMDGLEARGD--VIVIAATNRPDAIDPALRRPGRFDREIEIGVPD 351

Query: 523 ADNRKKILRIILKHENLDPDFQFDKLANLTDGYSGSDLKNLCITAAYRPVQELLEEEKAG 582
            + RK+IL I  +   L  D   ++LA LT+G+ G+DL+ LC  AA   ++ +L E    
Sbjct: 352 KEGRKEILEIHTRKMPLAEDVDLEELAELTNGFVGADLEALCKEAAMHALRRVLPEIDIE 411

Query: 583 DNNITNVALRPLNL--DDFVQSKSKVGPSVAYDAVSVNELRKWNEMYG 628
              I    +  L +  +DF+++   + PS   + +      KW ++ G
Sbjct: 412 AEEIPAEVIENLKVTREDFMEALKNIEPSAMREVLVEVPNVKWEDIGG 459


>MSP1_CAEEL (P54815) MSP1 protein homolog
          Length = 342

 Score =  198 bits (504), Expect = 3e-50
 Identities = 113/282 (40%), Positives = 168/282 (59%), Gaps = 11/282 (3%)

Query: 325 KNLAKDEFESNFISAVVPPGEIGVKFDDIGALEDVKKALNELVILPMRRPELFTHGNLLR 384
           + +   E E    +  V   ++G  +D+IG  E++   L + +ILP+R     +  +LL 
Sbjct: 57  RQIELSEHEIRIATQFVGGEDVGADWDEIGGCEELVAELKDRIILPLRFASQ-SGSHLLS 115

Query: 385 PVKGILLFGPPGTGKTLMAKALATEAGANFISVSGSTLTSKWFGDAEKLTKALFSFASKL 444
           P +GILL+GPPG GKTL+AKA+A  AG  FI++  S LT KW+G+++KL  A+FS A K 
Sbjct: 116 PPRGILLYGPPGCGKTLLAKAVARAAGCRFINLQVSNLTDKWYGESQKLAAAVFSVAQKF 175

Query: 445 APVIIFVDEVDSLLGARGGAFEHEATRRMRNEFMAAWDGLRSKENQRILILGATNRPFDL 504
            P IIF+DE+DS L  R  + +HE+T  M+ +FM  WDG  S  +Q I+++GATNRP D+
Sbjct: 176 QPTIIFIDEIDSFLRDR-QSHDHESTAMMKAQFMTLWDGFSSSGDQ-IIVMGATNRPRDV 233

Query: 505 DDAVIRRLPRRIYVDLPDADNRKKILRIILKHENLDPDFQFDKLANLTDGYSGSDLKNLC 564
           D A++RR+  R  V +P+A  R +IL +IL++E ++      ++A   +G SGSDLK +C
Sbjct: 234 DAAILRRMTARFQVPVPNAKQRSQILNVILRNEKINNTVNLGEIAQAAEGLSGSDLKEVC 293

Query: 565 ITAAYRPVQELLEEEKAGDNNITNV-ALRPLNLDDFVQSKSK 605
             A       LL   KA   +  +V  L PL   DF  +  K
Sbjct: 294 RLA-------LLARAKATVASGGSVNQLLPLEQSDFESAVHK 328


>VAT_THEAC (O05209) VCP-like ATPase
          Length = 745

 Score =  196 bits (497), Expect = 2e-49
 Identities = 122/346 (35%), Positives = 197/346 (56%), Gaps = 21/346 (6%)

Query: 291 VKGDKLCLPRESLEIAISR-LKGVETMSRQPSQSLKNLA--KDEFESNFISAVVPPG--- 344
           V  D   L RES   A+ R L  ++     P++ L+ +   +D+F+ N + ++ P     
Sbjct: 398 VGADLAALVRESAMNALRRYLPEIDLDKPIPTEILEKMVVTEDDFK-NALKSIEPSSLRE 456

Query: 345 ---EI-GVKFDDIGALEDVKKALNELVILPMRRPELFTHGNLLRPVKGILLFGPPGTGKT 400
              E+  V +DDIG LEDVK+ + E V LP+ +P++F    + RP KG LL+GPPG GKT
Sbjct: 457 VMVEVPNVHWDDIGGLEDVKREIKETVELPLLKPDVFKRLGI-RPSKGFLLYGPPGVGKT 515

Query: 401 LMAKALATEAGANFISVSGSTLTSKWFGDAEKLTKALFSFASKLAPVIIFVDEVDSLLGA 460
           L+AKA+ATE+ ANFIS+ G  + SKW G++EK  + +F  A ++AP I+F+DE+DS+   
Sbjct: 516 LLAKAVATESNANFISIKGPEVLSKWVGESEKAIREIFKKAKQVAPAIVFLDEIDSIAPR 575

Query: 461 RGGAFEHEATRRMRNEFMAAWDGLRSKENQRILILGATNRPFDLDDAVIR--RLPRRIYV 518
           RG   +   T R+ N+ + + DG+       ++++GATNRP  +D A++R  R  + IY+
Sbjct: 576 RGTTSDSGVTERIVNQLLTSLDGIEVMNG--VVVIGATNRPDIMDPALLRAGRFDKLIYI 633

Query: 519 DLPDADNRKKILRIILKHENLDPDFQFDKLANLTDGYSGSDLKNLCITAAYRPVQELLEE 578
             PD + R  IL++  K+  L PD   + +A  T+GY G+DL+NLC  A     +E  + 
Sbjct: 634 PPPDKEARLSILKVHTKNMPLAPDVDLNDIAQRTEGYVGADLENLCREAGMNAYRENPDA 693

Query: 579 EKAGDNNITNV--ALRPLNLDDFVQSKSKVGPSVAYDAVSVNELRK 622
                 N  +    +RP   ++ ++    +  ++   + SV+E RK
Sbjct: 694 TSVSQKNFLDALKTIRPSVDEEVIKFYRTLSETM---SKSVSERRK 736



 Score =  155 bits (393), Expect = 2e-37
 Identities = 110/351 (31%), Positives = 189/351 (53%), Gaps = 18/351 (5%)

Query: 289 PCVKGDKLCLPRESLEIAISRL-KGVETMSRQPSQSLKNLAKDEFESNFISAVVPPGEIG 347
           P ++ D + +P  +L      L K V+T+  +    +    K E      S V+   E+ 
Sbjct: 128 PMLEQDNISVPGLTLAGQTGLLFKVVKTLPSKVPVEIGEETKIEIREEPASEVLE--EVS 185

Query: 348 -VKFDDIGALEDVKKALNELVILPMRRPELFTHGNLLRPVKGILLFGPPGTGKTLMAKAL 406
            + ++DIG L +    + E++ LP++ PELF    +  P KG++L+GPPGTGKTL+A+A+
Sbjct: 186 RISYEDIGGLSEQLGKIREMIELPLKHPELFERLGITPP-KGVILYGPPGTGKTLIARAV 244

Query: 407 ATEAGANFISVSGSTLTSKWFGDAEKLTKALFSFASKLAPVIIFVDEVDSLLGARGGAFE 466
           A E+GANF+S++G  + SK++G +E+  + +FS A + AP IIF+DE+DS+   R    +
Sbjct: 245 ANESGANFLSINGPEIMSKYYGQSEQKLREIFSKAEETAPSIIFIDEIDSIAPKR-EEVQ 303

Query: 467 HEATRRMRNEFMAAWDGLRSKENQRILILGATNRPFDLDDAVIR--RLPRRIYVDLPDAD 524
            E  RR+  + +   DG+  KE   ++++GATNR   +D A+ R  R  R I + +PD +
Sbjct: 304 GEVERRVVAQLLTLMDGM--KERGHVIVIGATNRIDAIDPALRRPGRFDREIEIGVPDRN 361

Query: 525 NRKKILRIILKHENL-----DPDFQFDKLANLTDGYSGSDLKNLCITAAYRPVQELLEEE 579
            RK+IL I  ++  L     + +   +++A+ T G+ G+DL  L   +A   ++  L E 
Sbjct: 362 GRKEILMIHTRNMPLGMSEEEKNKFLEEMADYTYGFVGADLAALVRESAMNALRRYLPEI 421

Query: 580 KAGDNNITNVALRPLNL--DDFVQSKSKVGPSVAYDAVSVNELRKWNEMYG 628
              D  I    L  + +  DDF  +   + PS   + +       W+++ G
Sbjct: 422 DL-DKPIPTEILEKMVVTEDDFKNALKSIEPSSLREVMVEVPNVHWDDIGG 471


>SKD1_MOUSE (P46467) SKD1 protein (Vacuolar sorting protein 4b)
          Length = 444

 Score =  190 bits (483), Expect = 9e-48
 Identities = 115/262 (43%), Positives = 157/262 (59%), Gaps = 15/262 (5%)

Query: 348 VKFDDIGALEDVKKALNELVILPMRRPELFTHGNLLRPVKGILLFGPPGTGKTLMAKALA 407
           VK+ D+  LE  K+AL E VILP++ P LFT      P +GILLFGPPGTGK+ +AKA+A
Sbjct: 131 VKWSDVAGLEGAKEALKEAVILPIKFPHLFTGKRT--PWRGILLFGPPGTGKSYLAKAVA 188

Query: 408 TEAG-ANFISVSGSTLTSKWFGDAEKLTKALFSFASKLAPVIIFVDEVDSLLGARGGAFE 466
           TEA  + F S+S S L SKW G++EKL K LF  A +  P IIF+DE+DSL G+R    E
Sbjct: 189 TEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLCGSR-SENE 247

Query: 467 HEATRRMRNEFMAAWDGLRSKENQRILILGATNRPFDLDDAVIRRLPRRIYVDLPDADNR 526
            EA RR++ EF+    G+   +N  IL+LGATN P+ LD A+ RR  +RIY+ LP+A  R
Sbjct: 248 SEAARRIKTEFLVQMQGV-GVDNDGILVLGATNIPWVLDSAIRRRFEKRIYIPLPEAHAR 306

Query: 527 KKILRIIL-KHENLDPDFQFDKLANLTDGYSGSDLKNLCITAAYRPVQELLE-------- 577
             + R+ L   +N   +  F +L   TDGYSG+D+  +   A  +PV+++          
Sbjct: 307 AAMFRLHLGSTQNSLTEADFQELGRKTDGYSGADISIIVRDALMQPVRKVQSATHFKKVR 366

Query: 578 -EEKAGDNNITNVALRPLNLDD 598
              +A  N I N  L P +  D
Sbjct: 367 GPSRADPNCIVNDLLTPCSPGD 388


>VPS4_YEAST (P52917) Vacuolar protein sorting-associated protein
           VPS4 (END13 protein)
          Length = 437

 Score =  190 bits (482), Expect = 1e-47
 Identities = 112/268 (41%), Positives = 164/268 (60%), Gaps = 27/268 (10%)

Query: 325 KNLAKDEFESN----------FISAVVPPGEIGVKFDDIGALEDVKKALNELVILPMRRP 374
           K ++++E E N           +S+ +   +  VK++D+  LE  K+AL E VILP++ P
Sbjct: 97  KKISQEEGEDNGGEDNKKLRGALSSAILSEKPNVKWEDVAGLEGAKEALKEAVILPVKFP 156

Query: 375 ELFTHGNLLRPVKGILLFGPPGTGKTLMAKALATEAGANFISVSGSTLTSKWFGDAEKLT 434
            LF  GN  +P  GILL+GPPGTGK+ +AKA+ATEA + F SVS S L SKW G++EKL 
Sbjct: 157 HLFK-GNR-KPTSGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSKWMGESEKLV 214

Query: 435 KALFSFASKLAPVIIFVDEVDSLLGARGGAFEHEATRRMRNEFMAAWDGLRSKENQRILI 494
           K LF+ A +  P IIF+DEVD+L G RG   E EA+RR++ E +   +G+   ++Q +L+
Sbjct: 215 KQLFAMARENKPSIIFIDEVDALTGTRGEG-ESEASRRIKTELLVQMNGV-GNDSQGVLV 272

Query: 495 LGATNRPFDLDDAVIRRLPRRIYVDLPDADNRKKILRI-------ILKHENLDPDFQFDK 547
           LGATN P+ LD A+ RR  RRIY+ LPD   R  +  I       +L  E+      +  
Sbjct: 273 LGATNIPWQLDSAIRRRFERRIYIPLPDLAARTTMFEINVGDTPCVLTKED------YRT 326

Query: 548 LANLTDGYSGSDLKNLCITAAYRPVQEL 575
           L  +T+GYSGSD+  +   A  +P++++
Sbjct: 327 LGAMTEGYSGSDIAVVVKDALMQPIRKI 354


>TERA_XENLA (P23787) Transitional endoplasmic reticulum ATPase (TER
           ATPase) (15S Mg(2+)-ATPase p97 subunit)
          Length = 805

 Score =  187 bits (474), Expect = 1e-46
 Identities = 116/303 (38%), Positives = 177/303 (58%), Gaps = 16/303 (5%)

Query: 348 VKFDDIGALEDVKKALNELVILPMRRPELFTHGNLLRPVKGILLFGPPGTGKTLMAKALA 407
           V ++DIG LEDVK+ L ELV  P+  P+ F    +  P KG+L +GPPG GKTL+AKA+A
Sbjct: 474 VTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMT-PSKGVLFYGPPGCGKTLLAKAIA 532

Query: 408 TEAGANFISVSGSTLTSKWFGDAEKLTKALFSFASKLAPVIIFVDEVDSLLGARGGAFEH 467
            E  ANFIS+ G  L + WFG++E   + +F  A + AP ++F DE+DS+  ARGG    
Sbjct: 533 NECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGD 592

Query: 468 --EATRRMRNEFMAAWDGLRSKENQRILILGATNRPFDLDDAVIR--RLPRRIYVDLPDA 523
              A  R+ N+ +   DG+  K+N  + I+GATNRP  +D A++R  RL + IY+ LPD 
Sbjct: 593 GGGAADRVINQILTEMDGMSIKKN--VFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDE 650

Query: 524 DNRKKILRIILKHENLDPDFQFDKLANLTDGYSGSDLKNLCITAAYRPVQELLEEE-KAG 582
            +R  IL+  L+   +  D   D LA +T+G+SG+DL  +C  A    ++E +E E +  
Sbjct: 651 KSRMAILKANLRKSPVAKDVDVDFLAKMTNGFSGADLTEICQRACKLAIRESIENEIRRE 710

Query: 583 DNNITNVALRPLNLDDFV----QSKSKVGPSVAYDAVSVNELRKWNEMYGEGGTRTKSPF 638
            +  TN +   +  DD V    +   +    +A  +VS N++RK+ EM+ +   +++   
Sbjct: 711 RDRQTNPSAMEVEEDDPVPEIRRDHFEEAMRLARRSVSDNDIRKY-EMFAQTLQQSR--- 766

Query: 639 GFG 641
           GFG
Sbjct: 767 GFG 769



 Score =  163 bits (412), Expect = 1e-39
 Identities = 100/285 (35%), Positives = 156/285 (54%), Gaps = 8/285 (2%)

Query: 348 VKFDDIGALEDVKKALNELVILPMRRPELFTHGNLLRPVKGILLFGPPGTGKTLMAKALA 407
           V +DDIG        + E+V LP+R P LF    + +P +GILL+GPPGTGKTL+A+A+A
Sbjct: 201 VGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGV-KPPRGILLYGPPGTGKTLIARAVA 259

Query: 408 TEAGANFISVSGSTLTSKWFGDAEKLTKALFSFASKLAPVIIFVDEVDSLLGARGGAFEH 467
            E GA F  ++G  + SK  G++E   +  F  A K AP IIF+DE+D++   R      
Sbjct: 260 NETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKT-HG 318

Query: 468 EATRRMRNEFMAAWDGLRSKENQRILILGATNRPFDLDDAVIR--RLPRRIYVDLPDADN 525
           E  RR+ ++ +   DGL  K+   ++++ ATNRP  +D A+ R  R  R + + +PD+  
Sbjct: 319 EVERRIVSQLLTLMDGL--KQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDSTG 376

Query: 526 RKKILRIILKHENLDPDFQFDKLANLTDGYSGSDLKNLCITAAYRPVQELLEEEKAGDNN 585
           R +IL+I  K+  L  D   +++AN T G+ G+DL  LC  AA + +++ ++     D  
Sbjct: 377 RLEILQIHTKNMKLSDDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDET 436

Query: 586 ITNVALRPL--NLDDFVQSKSKVGPSVAYDAVSVNELRKWNEMYG 628
           I    +  L   +DDF    S+  PS   + V       W ++ G
Sbjct: 437 IDAEVMNSLAVTMDDFRWGLSQSNPSALRETVVEVPQVTWEDIGG 481


>TERA_RAT (P46462) Transitional endoplasmic reticulum ATPase (TER
           ATPase) (15S Mg(2+)-ATPase p97 subunit)
           (Valosin-containing protein) (VCP)
          Length = 806

 Score =  186 bits (471), Expect = 2e-46
 Identities = 117/309 (37%), Positives = 176/309 (56%), Gaps = 15/309 (4%)

Query: 348 VKFDDIGALEDVKKALNELVILPMRRPELFTHGNLLRPVKGILLFGPPGTGKTLMAKALA 407
           V ++DIG LEDVK+ L ELV  P+  P+ F    +  P KG+L +GPPG GKTL+AKA+A
Sbjct: 474 VTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMT-PSKGVLFYGPPGCGKTLLAKAIA 532

Query: 408 TEAGANFISVSGSTLTSKWFGDAEKLTKALFSFASKLAPVIIFVDEVDSLLGARGGAFEH 467
            E  ANFIS+ G  L + WFG++E   + +F  A + AP ++F DE+DS+  ARGG    
Sbjct: 533 NECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGD 592

Query: 468 --EATRRMRNEFMAAWDGLRSKENQRILILGATNRPFDLDDAVIR--RLPRRIYVDLPDA 523
              A  R+ N+ +   DG+ +K+N  + I+GATNRP  +D A++R  RL + IY+ LPD 
Sbjct: 593 GGGAADRVINQILTEMDGMSTKKN--VFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDE 650

Query: 524 DNRKKILRIILKHENLDPDFQFDKLANLTDGYSGSDLKNLCITAAYRPVQELLEEE-KAG 582
            +R  IL+  L+   +  D   + LA +T+G+SG+DL  +C  A    ++E +E E +  
Sbjct: 651 KSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRE 710

Query: 583 DNNITNVALRPLNLDDFV----QSKSKVGPSVAYDAVSVNELRKWNEMYGE--GGTRTKS 636
               TN +   +  DD V    +   +     A  +VS N++RK+ EM+ +    +R   
Sbjct: 711 RERQTNPSAMEVEEDDPVPEIRRDHFEEAMRFARRSVSDNDIRKY-EMFAQTLQQSRGFG 769

Query: 637 PFGFGQNNQ 645
            F F   NQ
Sbjct: 770 SFRFPSGNQ 778



 Score =  164 bits (414), Expect = 9e-40
 Identities = 101/285 (35%), Positives = 157/285 (54%), Gaps = 8/285 (2%)

Query: 348 VKFDDIGALEDVKKALNELVILPMRRPELFTHGNLLRPVKGILLFGPPGTGKTLMAKALA 407
           V +DDIG        + E+V LP+R P LF    + +P +GILL+GPPGTGKTL+A+A+A
Sbjct: 201 VGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGV-KPPRGILLYGPPGTGKTLIARAVA 259

Query: 408 TEAGANFISVSGSTLTSKWFGDAEKLTKALFSFASKLAPVIIFVDEVDSLLGARGGAFEH 467
            E GA F  ++G  + SK  G++E   +  F  A K AP IIF+DE+D++   R      
Sbjct: 260 NETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKT-HG 318

Query: 468 EATRRMRNEFMAAWDGLRSKENQRILILGATNRPFDLDDAVIR--RLPRRIYVDLPDADN 525
           E  RR+ ++ +   DGL  K+   ++++ ATNRP  +D A+ R  R  R + + +PDA  
Sbjct: 319 EVERRIVSQLLTLMDGL--KQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATG 376

Query: 526 RKKILRIILKHENLDPDFQFDKLANLTDGYSGSDLKNLCITAAYRPVQELLEEEKAGDNN 585
           R +IL+I  K+  L  D   +++AN T G+ G+DL  LC  AA + +++ ++     D  
Sbjct: 377 RLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDET 436

Query: 586 ITNVALRPL--NLDDFVQSKSKVGPSVAYDAVSVNELRKWNEMYG 628
           I    +  L   +DDF  + S+  PS   + V       W ++ G
Sbjct: 437 IDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGG 481


>TERA_MOUSE (Q01853) Transitional endoplasmic reticulum ATPase (TER
           ATPase) (15S Mg(2+)-ATPase p97 subunit)
           (Valosin-containing protein) (VCP)
          Length = 806

 Score =  186 bits (471), Expect = 2e-46
 Identities = 117/309 (37%), Positives = 176/309 (56%), Gaps = 15/309 (4%)

Query: 348 VKFDDIGALEDVKKALNELVILPMRRPELFTHGNLLRPVKGILLFGPPGTGKTLMAKALA 407
           V ++DIG LEDVK+ L ELV  P+  P+ F    +  P KG+L +GPPG GKTL+AKA+A
Sbjct: 474 VTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMT-PSKGVLFYGPPGCGKTLLAKAIA 532

Query: 408 TEAGANFISVSGSTLTSKWFGDAEKLTKALFSFASKLAPVIIFVDEVDSLLGARGGAFEH 467
            E  ANFIS+ G  L + WFG++E   + +F  A + AP ++F DE+DS+  ARGG    
Sbjct: 533 NECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGD 592

Query: 468 --EATRRMRNEFMAAWDGLRSKENQRILILGATNRPFDLDDAVIR--RLPRRIYVDLPDA 523
              A  R+ N+ +   DG+ +K+N  + I+GATNRP  +D A++R  RL + IY+ LPD 
Sbjct: 593 GGGAADRVINQILTEMDGMSTKKN--VFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDE 650

Query: 524 DNRKKILRIILKHENLDPDFQFDKLANLTDGYSGSDLKNLCITAAYRPVQELLEEE-KAG 582
            +R  IL+  L+   +  D   + LA +T+G+SG+DL  +C  A    ++E +E E +  
Sbjct: 651 KSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRE 710

Query: 583 DNNITNVALRPLNLDDFV----QSKSKVGPSVAYDAVSVNELRKWNEMYGE--GGTRTKS 636
               TN +   +  DD V    +   +     A  +VS N++RK+ EM+ +    +R   
Sbjct: 711 RERQTNPSAMEVEEDDPVPEIRRDHFEEAMRFARRSVSDNDIRKY-EMFAQTLQQSRGFG 769

Query: 637 PFGFGQNNQ 645
            F F   NQ
Sbjct: 770 SFRFPSGNQ 778



 Score =  163 bits (413), Expect = 1e-39
 Identities = 100/285 (35%), Positives = 157/285 (55%), Gaps = 8/285 (2%)

Query: 348 VKFDDIGALEDVKKALNELVILPMRRPELFTHGNLLRPVKGILLFGPPGTGKTLMAKALA 407
           V +DD+G        + E+V LP+R P LF    + +P +GILL+GPPGTGKTL+A+A+A
Sbjct: 201 VGYDDVGGCRKQLAQIKEMVELPLRHPALFKAIGV-KPPRGILLYGPPGTGKTLIARAVA 259

Query: 408 TEAGANFISVSGSTLTSKWFGDAEKLTKALFSFASKLAPVIIFVDEVDSLLGARGGAFEH 467
            E GA F  ++G  + SK  G++E   +  F  A K AP IIF+DE+D++   R      
Sbjct: 260 NETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKT-HG 318

Query: 468 EATRRMRNEFMAAWDGLRSKENQRILILGATNRPFDLDDAVIR--RLPRRIYVDLPDADN 525
           E  RR+ ++ +   DGL  K+   ++++ ATNRP  +D A+ R  R  R + + +PDA  
Sbjct: 319 EVERRIVSQLLTLMDGL--KQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATG 376

Query: 526 RKKILRIILKHENLDPDFQFDKLANLTDGYSGSDLKNLCITAAYRPVQELLEEEKAGDNN 585
           R +IL+I  K+  L  D   +++AN T G+ G+DL  LC  AA + +++ ++     D  
Sbjct: 377 RLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDET 436

Query: 586 ITNVALRPL--NLDDFVQSKSKVGPSVAYDAVSVNELRKWNEMYG 628
           I    +  L   +DDF  + S+  PS   + V       W ++ G
Sbjct: 437 IDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGG 481


>TERA_HUMAN (P55072) Transitional endoplasmic reticulum ATPase (TER
           ATPase) (15S Mg(2+)-ATPase p97 subunit)
           (Valosin-containing protein) (VCP)
          Length = 805

 Score =  186 bits (471), Expect = 2e-46
 Identities = 117/309 (37%), Positives = 176/309 (56%), Gaps = 15/309 (4%)

Query: 348 VKFDDIGALEDVKKALNELVILPMRRPELFTHGNLLRPVKGILLFGPPGTGKTLMAKALA 407
           V ++DIG LEDVK+ L ELV  P+  P+ F    +  P KG+L +GPPG GKTL+AKA+A
Sbjct: 473 VTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMT-PSKGVLFYGPPGCGKTLLAKAIA 531

Query: 408 TEAGANFISVSGSTLTSKWFGDAEKLTKALFSFASKLAPVIIFVDEVDSLLGARGGAFEH 467
            E  ANFIS+ G  L + WFG++E   + +F  A + AP ++F DE+DS+  ARGG    
Sbjct: 532 NECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGD 591

Query: 468 --EATRRMRNEFMAAWDGLRSKENQRILILGATNRPFDLDDAVIR--RLPRRIYVDLPDA 523
              A  R+ N+ +   DG+ +K+N  + I+GATNRP  +D A++R  RL + IY+ LPD 
Sbjct: 592 GGGAADRVINQILTEMDGMSTKKN--VFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDE 649

Query: 524 DNRKKILRIILKHENLDPDFQFDKLANLTDGYSGSDLKNLCITAAYRPVQELLEEE-KAG 582
            +R  IL+  L+   +  D   + LA +T+G+SG+DL  +C  A    ++E +E E +  
Sbjct: 650 KSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRE 709

Query: 583 DNNITNVALRPLNLDDFV----QSKSKVGPSVAYDAVSVNELRKWNEMYGE--GGTRTKS 636
               TN +   +  DD V    +   +     A  +VS N++RK+ EM+ +    +R   
Sbjct: 710 RERQTNPSAMEVEEDDPVPEIRRDHFEEAMRFARRSVSDNDIRKY-EMFAQTLQQSRGFG 768

Query: 637 PFGFGQNNQ 645
            F F   NQ
Sbjct: 769 SFRFPSGNQ 777



 Score =  164 bits (414), Expect = 9e-40
 Identities = 101/285 (35%), Positives = 157/285 (54%), Gaps = 8/285 (2%)

Query: 348 VKFDDIGALEDVKKALNELVILPMRRPELFTHGNLLRPVKGILLFGPPGTGKTLMAKALA 407
           V +DDIG        + E+V LP+R P LF    + +P +GILL+GPPGTGKTL+A+A+A
Sbjct: 200 VGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGV-KPPRGILLYGPPGTGKTLIARAVA 258

Query: 408 TEAGANFISVSGSTLTSKWFGDAEKLTKALFSFASKLAPVIIFVDEVDSLLGARGGAFEH 467
            E GA F  ++G  + SK  G++E   +  F  A K AP IIF+DE+D++   R      
Sbjct: 259 NETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKT-HG 317

Query: 468 EATRRMRNEFMAAWDGLRSKENQRILILGATNRPFDLDDAVIR--RLPRRIYVDLPDADN 525
           E  RR+ ++ +   DGL  K+   ++++ ATNRP  +D A+ R  R  R + + +PDA  
Sbjct: 318 EVERRIVSQLLTLMDGL--KQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATG 375

Query: 526 RKKILRIILKHENLDPDFQFDKLANLTDGYSGSDLKNLCITAAYRPVQELLEEEKAGDNN 585
           R +IL+I  K+  L  D   +++AN T G+ G+DL  LC  AA + +++ ++     D  
Sbjct: 376 RLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDET 435

Query: 586 ITNVALRPL--NLDDFVQSKSKVGPSVAYDAVSVNELRKWNEMYG 628
           I    +  L   +DDF  + S+  PS   + V       W ++ G
Sbjct: 436 IDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGG 480


>SKD1_HUMAN (O75351) SKD1 protein (Vacuolar sorting protein 4b)
          Length = 444

 Score =  186 bits (471), Expect = 2e-46
 Identities = 120/320 (37%), Positives = 178/320 (55%), Gaps = 42/320 (13%)

Query: 348 VKFDDIGALEDVKKALNELVILPMRRPELFTHGNLLRPVKGILLFGPPGTGKTLMAKALA 407
           VK+ D+  LE  K+AL E VILP++ P LFT      P +GILLFGPPGTGK+ +AKA+A
Sbjct: 131 VKWSDVAGLEGAKEALKEAVILPIKFPHLFTGKRT--PWRGILLFGPPGTGKSYLAKAVA 188

Query: 408 TEAG-ANFISVSGSTLTSKWFGDAEKLTKALFSFASKLAPVIIFVDEVDSLLGARGGAFE 466
           TEA  + F S+S S L SKW G++EKL K LF  A +  P IIF+DE+DSL G+R    E
Sbjct: 189 TEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLCGSR-SENE 247

Query: 467 HEATRRMRNEFMAAWDGLRSKENQRILILGATNRPFDLDDAVIRRLPRRIYVDLPDADNR 526
            EA RR++ EF+    G+   +N  IL+LGATN P+ LD A+ RR  +RIY+ LP+   R
Sbjct: 248 SEAARRIKTEFLVQMQGV-GVDNDGILVLGATNIPWVLDSAIRRRFEKRIYIPLPEPHAR 306

Query: 527 KKILRIIL-KHENLDPDFQFDKLANLTDGYSGSDLKNLCITAAYRPVQELLE-------- 577
             + ++ L   +N   +  F +L   TDGYSG+D+  +   A  +PV+++          
Sbjct: 307 AAMFKLHLGTTQNSLTEADFRELGRKTDGYSGADISIIVRDALMQPVRKVQSATHFKKVR 366

Query: 578 -EEKAGDNNITNVALRP-------------------------LNLDDFVQSKSKVGPSVA 611
              +A  N++ +  L P                         +++ D ++S S   P+V 
Sbjct: 367 GPSRADPNHLVDDLLTPCSPGDPGAIEMTWMDVPGDKLLEPVVSMSDMLRSLSNTKPTV- 425

Query: 612 YDAVSVNELRKWNEMYGEGG 631
            +   + +L+K+ E +G+ G
Sbjct: 426 -NEHDLLKLKKFTEDFGQEG 444


>YB56_METJA (Q58556) Cell division cycle protein 48 homolog MJ1156
          Length = 903

 Score =  184 bits (468), Expect = 5e-46
 Identities = 132/402 (32%), Positives = 213/402 (52%), Gaps = 27/402 (6%)

Query: 229 DRKIVISRSNLNELRKVLEEHQLSCVDLLHLDSDDVILTKQKAEKVVGWAKNHYLSSCLL 288
           DR+IVI   +    +++L+ H  +      +D D +      A+   G+      + C  
Sbjct: 339 DREIVIGVPDREGRKEILQIHTRNMPLAEDVDLDYL------ADVTHGFVGADLAALCKE 392

Query: 289 PCVKGDKLCLPR---ESLEIAISRLKGVETMSRQPSQSLKNLAKDEFESNFISAVVPPGE 345
             ++  +  LP    E+ EI    L  ++       ++LK++         +   VP   
Sbjct: 393 AAMRALRRVLPSIDLEAEEIPKEVLDNLKVTMDDFKEALKDVEPSAMREVLVE--VP--- 447

Query: 346 IGVKFDDIGALEDVKKALNELVILPMRRPELFTHGNLLRPVKGILLFGPPGTGKTLMAKA 405
             VK++DIG LE+VK+ L E V  P++  E+F    + RP KG+LLFGPPGTGKTL+AKA
Sbjct: 448 -NVKWEDIGGLEEVKQELREAVEWPLKAKEVFEKIGV-RPPKGVLLFGPPGTGKTLLAKA 505

Query: 406 LATEAGANFISVSGSTLTSKWFGDAEKLTKALFSFASKLAPVIIFVDEVDSLLGARGGAF 465
           +A E+GANFISV G  + SKW G++EK  + +F  A + AP IIF DE+D++   RG   
Sbjct: 506 VANESGANFISVKGPEIFSKWVGESEKAIREIFRKARQSAPCIIFFDEIDAIAPKRGRDL 565

Query: 466 EHEATRRMRNEFMAAWDGLRSKENQRILILGATNRPFDLDDAVIR--RLPRRIYVDLPDA 523
               T ++ N+ +   DG+  +E + ++++ ATNRP  +D A++R  RL R I V +PD 
Sbjct: 566 SSAVTDKVVNQLLTELDGM--EEPKDVVVIAATNRPDIIDPALLRPGRLDRVILVPVPDE 623

Query: 524 DNRKKILRIILKHENLDPDFQFDKLANLTDGYSGSDLKNLCITAAYRPVQELLEEEKAGD 583
             R  I +I  +  NL  D   ++LA  T+GY+G+D++ LC  AA   V+E + +     
Sbjct: 624 KARLDIFKIHTRSMNLAEDVNLEELAKKTEGYTGADIEALCREAAMLAVRESIGKP---- 679

Query: 584 NNITNVALRPLNLDDFVQSKSKVGPSVAYDAVSVNELRKWNE 625
               ++ ++   L +++QS S    + A +  SV +  K  E
Sbjct: 680 ---WDIEVKLRELINYLQSISGTFRAAAVELNSVIKATKERE 718



 Score =  183 bits (464), Expect = 1e-45
 Identities = 110/285 (38%), Positives = 166/285 (57%), Gaps = 8/285 (2%)

Query: 348 VKFDDIGALEDVKKALNELVILPMRRPELFTHGNLLRPVKGILLFGPPGTGKTLMAKALA 407
           V ++DIG L++  K + E++ LPMR PELF    +  P KG+LL GPPGTGKTL+AKA+A
Sbjct: 176 VTYEDIGGLKEEVKKVREMIELPMRHPELFEKLGI-EPPKGVLLVGPPGTGKTLLAKAVA 234

Query: 408 TEAGANFISVSGSTLTSKWFGDAEKLTKALFSFASKLAPVIIFVDEVDSLLGARGGAFEH 467
            EAGANF  ++G  + SK+ G+ E+  + +F  A + AP IIF+DE+D++   R  A   
Sbjct: 235 NEAGANFYVINGPEIMSKYVGETEENLRKIFEEAEENAPSIIFIDEIDAIAPKRDEA-TG 293

Query: 468 EATRRMRNEFMAAWDGLRSKENQRILILGATNRPFDLDDAVIR--RLPRRIYVDLPDADN 525
           E  RR+  + +   DGL+ +   +++++GATNRP  LD A+ R  R  R I + +PD + 
Sbjct: 294 EVERRLVAQLLTLMDGLKGR--GQVVVIGATNRPNALDPALRRPGRFDREIVIGVPDREG 351

Query: 526 RKKILRIILKHENLDPDFQFDKLANLTDGYSGSDLKNLCITAAYRPVQELLEEEKAGDNN 585
           RK+IL+I  ++  L  D   D LA++T G+ G+DL  LC  AA R ++ +L         
Sbjct: 352 RKEILQIHTRNMPLAEDVDLDYLADVTHGFVGADLAALCKEAAMRALRRVLPSIDLEAEE 411

Query: 586 ITNVALRPL--NLDDFVQSKSKVGPSVAYDAVSVNELRKWNEMYG 628
           I    L  L   +DDF ++   V PS   + +      KW ++ G
Sbjct: 412 IPKEVLDNLKVTMDDFKEALKDVEPSAMREVLVEVPNVKWEDIGG 456


>TERA_PIG (P03974) Transitional endoplasmic reticulum ATPase (TER
           ATPase) (15S Mg(2+)-ATPase p97 subunit)
           (Valosin-containing protein) (VCP)
          Length = 806

 Score =  184 bits (468), Expect = 5e-46
 Identities = 116/309 (37%), Positives = 176/309 (56%), Gaps = 15/309 (4%)

Query: 348 VKFDDIGALEDVKKALNELVILPMRRPELFTHGNLLRPVKGILLFGPPGTGKTLMAKALA 407
           V ++DIG LEDVK+ L +LV  P+  P+ F    +  P KG+L +GPPG GKTL+AKA+A
Sbjct: 474 VTWEDIGGLEDVKRELQDLVQYPVEHPDKFLKFGMT-PSKGVLFYGPPGCGKTLLAKAIA 532

Query: 408 TEAGANFISVSGSTLTSKWFGDAEKLTKALFSFASKLAPVIIFVDEVDSLLGARGGAFEH 467
            E  ANFIS+ G  L + WFG++E   + +F  A + AP ++F DE+DS+  ARGG    
Sbjct: 533 NECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGD 592

Query: 468 --EATRRMRNEFMAAWDGLRSKENQRILILGATNRPFDLDDAVIR--RLPRRIYVDLPDA 523
              A  R+ N+ +   DG+ +K+N  + I+GATNRP  +D A++R  RL + IY+ LPD 
Sbjct: 593 GGGAADRVINQILTEMDGMSTKKN--VFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDE 650

Query: 524 DNRKKILRIILKHENLDPDFQFDKLANLTDGYSGSDLKNLCITAAYRPVQELLEEE-KAG 582
            +R  IL+  L+   +  D   + LA +T+G+SG+DL  +C  A    ++E +E E +  
Sbjct: 651 KSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRE 710

Query: 583 DNNITNVALRPLNLDDFV----QSKSKVGPSVAYDAVSVNELRKWNEMYGE--GGTRTKS 636
               TN +   +  DD V    +   +     A  +VS N++RK+ EM+ +    +R   
Sbjct: 711 RERQTNPSAMEVEEDDPVPEIRRDHFEEAMRFARRSVSDNDIRKY-EMFAQTLQQSRGFG 769

Query: 637 PFGFGQNNQ 645
            F F   NQ
Sbjct: 770 SFRFPSGNQ 778



 Score =  164 bits (414), Expect = 9e-40
 Identities = 101/285 (35%), Positives = 157/285 (54%), Gaps = 8/285 (2%)

Query: 348 VKFDDIGALEDVKKALNELVILPMRRPELFTHGNLLRPVKGILLFGPPGTGKTLMAKALA 407
           V +DDIG        + E+V LP+R P LF    + +P +GILL+GPPGTGKTL+A+A+A
Sbjct: 201 VGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGV-KPPRGILLYGPPGTGKTLIARAVA 259

Query: 408 TEAGANFISVSGSTLTSKWFGDAEKLTKALFSFASKLAPVIIFVDEVDSLLGARGGAFEH 467
            E GA F  ++G  + SK  G++E   +  F  A K AP IIF+DE+D++   R      
Sbjct: 260 NETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKT-HG 318

Query: 468 EATRRMRNEFMAAWDGLRSKENQRILILGATNRPFDLDDAVIR--RLPRRIYVDLPDADN 525
           E  RR+ ++ +   DGL  K+   ++++ ATNRP  +D A+ R  R  R + + +PDA  
Sbjct: 319 EVERRIVSQLLTLMDGL--KQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATG 376

Query: 526 RKKILRIILKHENLDPDFQFDKLANLTDGYSGSDLKNLCITAAYRPVQELLEEEKAGDNN 585
           R +IL+I  K+  L  D   +++AN T G+ G+DL  LC  AA + +++ ++     D  
Sbjct: 377 RLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDET 436

Query: 586 ITNVALRPL--NLDDFVQSKSKVGPSVAYDAVSVNELRKWNEMYG 628
           I    +  L   +DDF  + S+  PS   + V       W ++ G
Sbjct: 437 IDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGG 481


>CC48_YEAST (P25694) Cell division control protein 48
          Length = 835

 Score =  183 bits (464), Expect = 1e-45
 Identities = 97/239 (40%), Positives = 149/239 (61%), Gaps = 7/239 (2%)

Query: 346 IGVKFDDIGALEDVKKALNELVILPMRRPELFTHGNLLRPVKGILLFGPPGTGKTLMAKA 405
           + V +DD+G L+++K+ L E V  P+  P+ +T   L  P KG+L +GPPGTGKTL+AKA
Sbjct: 482 VNVTWDDVGGLDEIKEELKETVEYPVLHPDQYTKFGL-SPSKGVLFYGPPGTGKTLLAKA 540

Query: 406 LATEAGANFISVSGSTLTSKWFGDAEKLTKALFSFASKLAPVIIFVDEVDSLLGARGGAF 465
           +ATE  ANFISV G  L S W+G++E   + +F  A   AP ++F+DE+DS+  ARGG+ 
Sbjct: 541 VATEVSANFISVKGPELLSMWYGESESNIRDIFDKARAAAPTVVFLDELDSIAKARGGSL 600

Query: 466 EHE--ATRRMRNEFMAAWDGLRSKENQRILILGATNRPFDLDDAVIR--RLPRRIYVDLP 521
                A+ R+ N+ +   DG+ +K+N  + ++GATNRP  +D A++R  RL + IYV LP
Sbjct: 601 GDAGGASDRVVNQLLTEMDGMNAKKN--VFVIGATNRPDQIDPAILRPGRLDQLIYVPLP 658

Query: 522 DADNRKKILRIILKHENLDPDFQFDKLANLTDGYSGSDLKNLCITAAYRPVQELLEEEK 580
           D + R  IL   L+   L+P  +   +A  T G+SG+DL  +   AA   +++ +E  +
Sbjct: 659 DENARLSILNAQLRKTPLEPGLELTAIAKATQGFSGADLLYIVQRAAKYAIKDSIEAHR 717



 Score =  167 bits (424), Expect = 6e-41
 Identities = 99/285 (34%), Positives = 160/285 (55%), Gaps = 8/285 (2%)

Query: 348 VKFDDIGALEDVKKALNELVILPMRRPELFTHGNLLRPVKGILLFGPPGTGKTLMAKALA 407
           V +DDIG        + E+V LP+R P+LF    + +P +G+L++GPPGTGKTLMA+A+A
Sbjct: 211 VGYDDIGGCRKQMAQIREMVELPLRHPQLFKAIGI-KPPRGVLMYGPPGTGKTLMARAVA 269

Query: 408 TEAGANFISVSGSTLTSKWFGDAEKLTKALFSFASKLAPVIIFVDEVDSLLGARGGAFEH 467
            E GA F  ++G  + SK  G++E   +  F  A K AP IIF+DE+DS+   R      
Sbjct: 270 NETGAFFFLINGPEVMSKMAGESESNLRKAFEEAEKNAPAIIFIDEIDSIAPKRDKT-NG 328

Query: 468 EATRRMRNEFMAAWDGLRSKENQRILILGATNRPFDLDDAVIR--RLPRRIYVDLPDADN 525
           E  RR+ ++ +   DG++++ N  ++++ ATNRP  +D A+ R  R  R + + +PDA  
Sbjct: 329 EVERRVVSQLLTLMDGMKARSN--VVVIAATNRPNSIDPALRRFGRFDREVDIGIPDATG 386

Query: 526 RKKILRIILKHENLDPDFQFDKLANLTDGYSGSDLKNLCITAAYRPVQELLEEEKAGDNN 585
           R ++LRI  K+  L  D   + LA  T GY G+D+ +LC  AA + ++E ++     ++ 
Sbjct: 387 RLEVLRIHTKNMKLADDVDLEALAAETHGYVGADIASLCSEAAMQQIREKMDLIDLDEDE 446

Query: 586 ITNVALRPL--NLDDFVQSKSKVGPSVAYDAVSVNELRKWNEMYG 628
           I    L  L   +D+F  +     PS   + V  +    W+++ G
Sbjct: 447 IDAEVLDSLGVTMDNFRFALGNSNPSALRETVVESVNVTWDDVGG 491


  Database: sprot
    Posted date:  Nov 25, 2004 10:54 AM
  Number of letters in database: 59,974,054
  Number of sequences in database:  164,201
  
Lambda     K      H
   0.318    0.136    0.395 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 77,396,792
Number of Sequences: 164201
Number of extensions: 3382632
Number of successful extensions: 12417
Number of sequences better than 10.0: 829
Number of HSP's better than 10.0 without gapping: 556
Number of HSP's successfully gapped in prelim test: 274
Number of HSP's that attempted gapping in prelim test: 10982
Number of HSP's gapped (non-prelim): 1182
length of query: 645
length of database: 59,974,054
effective HSP length: 117
effective length of query: 528
effective length of database: 40,762,537
effective search space: 21522619536
effective search space used: 21522619536
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 69 (31.2 bits)