BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= TM0135.8
(1406 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
CC7_SCHPO (P41892) Cell division control protein 7 (EC 2.7.1.-) 391 e-108
M3K3_ARATH (O22042) Mitogen-activated protein kinase kinase kina... 227 2e-58
M3K1_ARATH (O22040) Mitogen-activated protein kinase kinase kina... 225 8e-58
M3K2_ARATH (Q9FZ36) Mitogen-activated protein kinase kinase kina... 223 4e-57
BYR2_SCHPO (P28829) Protein kinase byr2 (EC 2.7.1.-) (Protein ki... 214 1e-54
ST25_HUMAN (O00506) Serine/threonine-protein kinase 25 (EC 2.7.1... 211 1e-53
CC15_YEAST (P27636) Cell division control protein 15 (EC 2.7.1.-) 211 1e-53
ST25_MOUSE (Q9Z2W1) Serine/threonine-protein kinase 25 (EC 2.7.1... 210 3e-53
ST24_HUMAN (Q9Y6E0) Serine/threonine-protein kinase 24 (EC 2.7.1... 206 4e-52
STK4_HUMAN (Q13043) Serine/threonine-protein kinase 4 (EC 2.7.1.... 205 8e-52
SID1_SCHPO (O14305) Serine/threonine-protein kinase sid1 (EC 2.7... 201 1e-50
HPO_DROME (Q8T0S6) Serine/threonine-protein kinase hippo (EC 2.7... 199 4e-50
STK3_MOUSE (Q9JI10) Serine/threonine-protein kinase 3 (EC 2.7.1.... 198 1e-49
STK3_HUMAN (Q13188) Serine/threonine-protein kinase 3 (EC 2.7.1.... 198 1e-49
M3K3_MOUSE (Q61084) Mitogen-activated protein kinase kinase kina... 194 2e-48
M3K3_HUMAN (Q99759) Mitogen-activated protein kinase kinase kina... 194 2e-48
WR19_ARATH (Q9SZ67) Probable WRKY transcription factor 19 (WRKY ... 193 2e-48
MKH1_SCHPO (Q10407) MAP kinase kinase kinase mkh1 (EC 2.7.1.-) 187 2e-46
M4K3_RAT (Q924I2) Mitogen-activated protein kinase kinase kinase... 186 3e-46
M4K5_MOUSE (Q8BPM2) Mitogen-activated protein kinase kinase kina... 186 5e-46
>CC7_SCHPO (P41892) Cell division control protein 7 (EC 2.7.1.-)
Length = 1062
Score = 391 bits (1005), Expect = e-108
Identities = 272/774 (35%), Positives = 403/774 (51%), Gaps = 80/774 (10%)
Query: 22 LGDEIGKGAYGRVYKGLDLENGDFVAIKQVSLENIAQEDLNIIMEMINILQNLNHKNIVK 81
LGD +GKGA+G VY+GL+++NG+ VA+K+V L + + DL++I I++L+NL+H NIVK
Sbjct: 11 LGDCLGKGAFGAVYRGLNIKNGETVAVKKVKLSKMLKSDLSVIKMEIDLLKNLDHPNIVK 70
Query: 82 YLGSLKTKSHLHIILEYVENGSLANIIKPNKFGPFPESLVAVYIAQVLEGLVYLHEQGVI 141
Y GS +T L IILEY ENGSL +I K FG PE+LVA+Y QVL+GL+YLH QGVI
Sbjct: 71 YRGSYQTNDSLCIILEYCENGSLRSICK--NFGKIPENLVALYTFQVLQGLLYLHNQGVI 128
Query: 142 HRDIKGANILTTKEGLVKLADFGVATKLTEADINTHSVVGTPYWMAPEVIEMSGVCAASD 201
HRDIKGANILTTK+G +KLADFGVATK+ + HSVVG+PYWMAPEVIE+ G ASD
Sbjct: 129 HRDIKGANILTTKDGTIKLADFGVATKINA--LEDHSVVGSPYWMAPEVIELVGATTASD 186
Query: 202 IWSVGCTVIELLTCVPPYYDLQPMPALFRIVQDEQPPIPDSLSPNITDFLHQCFKKDARQ 261
IWSVGCTVIELL PPYYDL P ALFR+V+DE PP+P ++S FL QCF+KD
Sbjct: 187 IWSVGCTVIELLDGNPPYYDLDPTSALFRMVKDEHPPLPSNISSAAKSFLMQCFQKDPNL 246
Query: 262 RPDAKTLLSHPWILNCRRVLQSSLRHSGTLRTIKDDGSAVAEVSGGDHKSTGEGSSVEKE 321
R + LL HPW++ + Q+S + S + ++ V E +
Sbjct: 247 RIKTRKLLKHPWVI----MNQTSSKFSDAIDEVQKYNERVKESTLTAIIEPTSNRINPTL 302
Query: 322 DSAKEFSTGEANSRKSHEDNASD-SNFSNE--RTEKEDDIPSDQVLTLAIREKSFLRTGS 378
S ++ S S K+ + D N+ NE T K SD VL + F
Sbjct: 303 HSGRQSSYHMPESPKTPIAESPDHDNWDNEFQGTLK----ISDDVLKKSEHFMDFCSNFK 358
Query: 379 GNLSSSIEVVSAEPTGTETSNAKDLHEVIMNGEVESPQSRG-KANMAVGK---DSSINNR 434
G +SS + S+ N+ + E N SP S KA K + SI+++
Sbjct: 359 GKNNSS-SITSSPSKSRHAFNSDQISE--SNNFNASPLSTPLKAQFDPSKPALNRSIDHQ 415
Query: 435 TKPFAFEPRGQDSGSLKAMKIPPPVEGNELSRFSDPPGDAYLDDLFHPSDKQSGEVVAEA 494
P + + S K IP +E +F + P D+ D+F S + + E
Sbjct: 416 KTP---QHKRYLSTEFKE-NIPDGIE-----KFVETPRDSEFTDIFPTSSIKVQGLRKET 466
Query: 495 STSTSTSHIAKG---NVSMNDGGKNDLAKELRATIARKQWEKESEIGQENNGGNLLHRVM 551
T + G N DG ++D+ + + E + + + +LL
Sbjct: 467 GLGTLVLNKCYGSWNNEENEDGEESDIFDSIETNLENLDIENNIALDKRTHLASLL---- 522
Query: 552 IGVLKDDVIDIDGLVFDDKLPGENLFPLQAVEFSKLVGSLRTEE--SEDVIVSACQKLIG 609
S L+GSLR + S+D VS ++
Sbjct: 523 ---------------------------------SSLLGSLRDKNIGSKDTTVS---QIAS 546
Query: 610 IFHQRPEQKIVFVTQHGLLPLTDLL-EVPKTRVICSVLQLINQIVKDNTDFQENACLVGL 668
I + K + HG+LPL + L E+ V +L+LIN + D+ + C G
Sbjct: 547 ILSEDLSLKREIIQAHGILPLLETLREIKTPDVQLLLLKLINTVAFDDHTTLQKVCFAGG 606
Query: 669 IPAVMSFAVSDRPREIRMEAAYFLQQLCQSSSLTLQMFIACRGIPVLVGFLEADYAKYRE 728
+P ++SF+ + E R E+A F+QQ+ ++S+LTLQMF++ G+ L+ F++ DY R+
Sbjct: 607 LPLMLSFSNREHSFEFRYESAIFIQQMYRTSALTLQMFLSSNGLNSLLLFIKEDYGTNRD 666
Query: 729 MVHLAIDGMWQVFKLQQTTPRNDFCRIAAKNG---ILLRLINTLYSLNESTRLA 779
V + ++G+W++ + Q P+ND C + + + ++ L + ++S+R++
Sbjct: 667 FVFVGVEGIWKLLRQQDYIPKNDICTMVVNDSLEPLTKAMLKALATDDDSSRMS 720
Score = 122 bits (305), Expect = 9e-27
Identities = 94/324 (29%), Positives = 162/324 (49%), Gaps = 11/324 (3%)
Query: 1084 DVAREYLEKVADLLLEFAQADTTVKSYMCSQSLLSRLFQMFNRVEPPILLKILKCINHLS 1143
D +R L ++ ++LL +QAD VK + +S L R+ ++ + + L+ LS
Sbjct: 715 DSSRMSLTRICEILLALSQADNYVKESLLCESALRRILRILLYLPHSDMAITLQFFKQLS 774
Query: 1144 TDPNCLENLQRAEAIK---HLIPNLELKEGTLVSEIHHEVLNALFNLCKINKRRQEQAAE 1200
P+ L L++ I H++ + ++++G EI E L ALFN+CK++K+ QE+A
Sbjct: 775 MVPSSLSLLRKVHIIPLLTHILGDSKIEKGR--KEIRSEALAALFNVCKLDKKSQEEAVI 832
Query: 1201 NGIIPHLMQFITSNSPLKQYALPLLCDMAHASRNSREQLRAHGGLDVYLNLLEDELWSVT 1260
+G IP L + I + K++ALP+L + A SR L + LD +L+LL D W
Sbjct: 833 SGAIPLLQEVIIKDRLFKEFALPILLALPQAGPVSRIYLWQNKCLDFFLSLLSDLNWQSA 892
Query: 1261 ALDSIAVCLAHDNDNRKVEQSLLKKDAVQKLVKFFQSCPEQHFVHILEPFLKIITKSSRI 1320
D+IA L + R+V++ L +K VQ ++K F +L+ ++ S R+
Sbjct: 893 VFDTIASWLQF--ELREVQRVLAEKRNVQLVLKVFCISQSASSNRMLDTLGRVCQISPRL 950
Query: 1321 NTTLAVNGLTPLLIARLDHQDA--IARLNLLRLIKAVYEHHPQPKKLIVENDLPEKLQNL 1378
+ + +L H+ I LN+ +++K++ E Q I LP+ + NL
Sbjct: 951 AASYGQPIIFQKFKEKLTHKGTKPIVVLNIFQIMKSMCEASSQSVAYIAHCGLPDVVANL 1010
Query: 1379 IGERRDGQVLVKQMATSLLKALHI 1402
+ VLVK++A LLK L +
Sbjct: 1011 --NQTSDSVLVKELAKDLLKYLKV 1032
>M3K3_ARATH (O22042) Mitogen-activated protein kinase kinase kinase
3 (EC 2.7.1.-) (Arabidospsis NPK1-related protein kinase
3)
Length = 651
Score = 227 bits (579), Expect = 2e-58
Identities = 122/282 (43%), Positives = 184/282 (64%), Gaps = 12/282 (4%)
Query: 19 KYMLGDEIGKGAYGRVYKGLDLENGDFVAIKQVSL------ENIAQEDLNIIMEMINILQ 72
++ G+ IG GA+GRVY G++L++G+ +AIKQV + + Q + + E + +L+
Sbjct: 67 RWRKGELIGCGAFGRVYMGMNLDSGELLAIKQVLIAPSSASKEKTQGHIRELEEEVQLLK 126
Query: 73 NLNHKNIVKYLGSLKTKSHLHIILEYVENGSLANIIKPNKFGPFPESLVAVYIAQVLEGL 132
NL+H NIV+YLG+++ L+I++E+V GS++++++ KFG FPE ++ +Y Q+L GL
Sbjct: 127 NLSHPNIVRYLGTVRESDSLNILMEFVPGGSISSLLE--KFGSFPEPVIIMYTKQLLLGL 184
Query: 133 VYLHEQGVIHRDIKGANILTTKEGLVKLADFGVATKLTE-ADIN-THSVVGTPYWMAPEV 190
YLH G++HRDIKGANIL +G ++LADFG + K+ E A +N S+ GTPYWMAPEV
Sbjct: 185 EYLHNNGIMHRDIKGANILVDNKGCIRLADFGASKKVVELATVNGAKSMKGTPYWMAPEV 244
Query: 191 IEMSGVCAASDIWSVGCTVIELLTCVPPYYD-LQPMPALFRIVQDE-QPPIPDSLSPNIT 248
I +G ++DIWSVGCTVIE+ T PP+ + Q A+ I + + PPIP+ LSP
Sbjct: 245 ILQTGHSFSADIWSVGCTVIEMATGKPPWSEQYQQFAAVLHIGRTKAHPPIPEDLSPEAK 304
Query: 249 DFLHQCFKKDARQRPDAKTLLSHPWILNCRRVLQSSLRHSGT 290
DFL +C K+ R A LL HP++ R+ + R+S T
Sbjct: 305 DFLMKCLHKEPSLRLSATELLQHPFVTGKRQEPYPAYRNSLT 346
>M3K1_ARATH (O22040) Mitogen-activated protein kinase kinase kinase
1 (EC 2.7.1.-) (Arabidospsis NPK1-related protein kinase
1)
Length = 666
Score = 225 bits (573), Expect = 8e-58
Identities = 140/374 (37%), Positives = 222/374 (58%), Gaps = 25/374 (6%)
Query: 23 GDEIGKGAYGRVYKGLDLENGDFVAIKQVSLE-NIAQED-----LNIIMEMINILQNLNH 76
G IG+GA+G VY G++L++G+ +A+KQV + N A ++ + + E + +L+NL+H
Sbjct: 72 GQLIGRGAFGTVYMGMNLDSGELLAVKQVLIAANFASKEKTQAHIQELEEEVKLLKNLSH 131
Query: 77 KNIVKYLGSLKTKSHLHIILEYVENGSLANIIKPNKFGPFPESLVAVYIAQVLEGLVYLH 136
NIV+YLG+++ L+I+LE+V GS++++++ KFGPFPES+V Y Q+L GL YLH
Sbjct: 132 PNIVRYLGTVREDDTLNILLEFVPGGSISSLLE--KFGPFPESVVRTYTRQLLLGLEYLH 189
Query: 137 EQGVIHRDIKGANILTTKEGLVKLADFGVATKLTEADINT--HSVVGTPYWMAPEVIEMS 194
++HRDIKGANIL +G +KLADFG + ++ E T S+ GTPYWMAPEVI +
Sbjct: 190 NHAIMHRDIKGANILVDNKGCIKLADFGASKQVAELATMTGAKSMKGTPYWMAPEVILQT 249
Query: 195 GVCAASDIWSVGCTVIELLTCVPPY-YDLQPMPALFRI-VQDEQPPIPDSLSPNITDFLH 252
G ++DIWSVGCTVIE++T P+ + + A+F I PPIPD+LS + DFL
Sbjct: 250 GHSFSADIWSVGCTVIEMVTGKAPWSQQYKEVAAIFFIGTTKSHPPIPDTLSSDAKDFLL 309
Query: 253 QCFKKDARQRPDAKTLLSHPWILNCRRVLQSSLRHSGTLRTIKDDGSAVAEVSGGDHKST 312
+C ++ RP A LL HP+++ + S+ L ++ ++ S + + KST
Sbjct: 310 KCLQEVPNLRPTASELLKHPFVMGKHKESAST-----DLGSVLNNLSTPLPLQINNTKST 364
Query: 313 GEGSSVEKEDSAKEFSTGEANSRKSHEDNASDSNFSNERTEKEDDIPSDQVLTLAIREKS 372
+ + +D + G N S D + N+ +++D D+ I +++
Sbjct: 365 PDSTC---DDVGDMCNFGSLN--YSLVDPV--KSIQNKNLWQQNDNGGDEDDMCLIDDEN 417
Query: 373 FLRTGSGNLSSSIE 386
FL T G +SS++E
Sbjct: 418 FL-TFDGEMSSTLE 430
>M3K2_ARATH (Q9FZ36) Mitogen-activated protein kinase kinase kinase
2 (EC 2.7.1.-) (Arabidospsis NPK1-related protein kinase
2)
Length = 651
Score = 223 bits (567), Expect = 4e-57
Identities = 121/288 (42%), Positives = 184/288 (63%), Gaps = 22/288 (7%)
Query: 7 SSAFTKSKTLDN----------KYMLGDEIGKGAYGRVYKGLDLENGDFVAIKQVSL--- 53
S F KS++ N ++ G IG+GA+G VY G++L++G+ +A+KQV +
Sbjct: 45 SMVFAKSQSPPNNSTVQIKPPIRWRKGQLIGRGAFGTVYMGMNLDSGELLAVKQVLITSN 104
Query: 54 ---ENIAQEDLNIIMEMINILQNLNHKNIVKYLGSLKTKSHLHIILEYVENGSLANIIKP 110
+ Q + + E + +L+NL+H NIV+YLG+++ L+I+LE+V GS++++++
Sbjct: 105 CASKEKTQAHIQELEEEVKLLKNLSHPNIVRYLGTVREDETLNILLEFVPGGSISSLLE- 163
Query: 111 NKFGPFPESLVAVYIAQVLEGLVYLHEQGVIHRDIKGANILTTKEGLVKLADFGVATKLT 170
KFG FPES+V Y Q+L GL YLH ++HRDIKGANIL +G +KLADFG + ++
Sbjct: 164 -KFGAFPESVVRTYTNQLLLGLEYLHNHAIMHRDIKGANILVDNQGCIKLADFGASKQVA 222
Query: 171 E-ADIN-THSVVGTPYWMAPEVIEMSGVCAASDIWSVGCTVIELLTCVPPY-YDLQPMPA 227
E A I+ S+ GTPYWMAPEVI +G ++DIWSVGCTVIE++T P+ + + A
Sbjct: 223 ELATISGAKSMKGTPYWMAPEVILQTGHSFSADIWSVGCTVIEMVTGKAPWSQQYKEIAA 282
Query: 228 LFRI-VQDEQPPIPDSLSPNITDFLHQCFKKDARQRPDAKTLLSHPWI 274
+F I PPIPD++S + DFL +C +++ RP A LL HP++
Sbjct: 283 IFHIGTTKSHPPIPDNISSDANDFLLKCLQQEPNLRPTASELLKHPFV 330
>BYR2_SCHPO (P28829) Protein kinase byr2 (EC 2.7.1.-) (Protein
kinase ste8) (MAPK kinase kinase) (MAPKKK)
Length = 659
Score = 214 bits (546), Expect = 1e-54
Identities = 117/291 (40%), Positives = 179/291 (61%), Gaps = 19/291 (6%)
Query: 1 MSRQSTSSAFTKSKTLDN-----KYMLGDEIGKGAYGRVYKGLDLENGDFVAIKQVSLEN 55
+S ST+S T + D K++ G IG G++G+VY G++ +G+ +A+KQV L++
Sbjct: 370 ISPTSTTSEDTNTLEEDTDDQSIKWIRGALIGSGSFGQVYLGMNASSGELMAVKQVILDS 429
Query: 56 IAQED------LNIIMEMINILQNLNHKNIVKYLGSLKTKSHLHIILEYVENGSLANIIK 109
+++ L+ + I +LQ L+H++IV+YLGS HL+I LEYV GS+A ++
Sbjct: 430 VSESKDRHAKLLDALAGEIALLQELSHEHIVQYLGSNLNSDHLNIFLEYVPGGSVAGLL- 488
Query: 110 PNKFGPFPESLVAVYIAQVLEGLVYLHEQGVIHRDIKGANILTTKEGLVKLADFGVATKL 169
+G F E+LV +I Q L+GL YLH +G++HRDIKGANIL +G +K++DFG++ KL
Sbjct: 489 -TMYGSFEETLVKNFIKQTLKGLEYLHSRGIVHRDIKGANILVDNKGKIKISDFGISKKL 547
Query: 170 TEADINTH------SVVGTPYWMAPEVIEMSGVCAASDIWSVGCTVIELLTCVPPYYDLQ 223
+T S G+ +WMAPEV++ + +DIWS+GC VIE+LT PY +
Sbjct: 548 ELNSTSTKTGGARPSFQGSSFWMAPEVVKQTMHTEKTDIWSLGCLVIEMLTSKHPYPNCD 607
Query: 224 PMPALFRIVQDEQPPIPDSLSPNITDFLHQCFKKDARQRPDAKTLLSHPWI 274
M A+FRI ++ P P ++S + DFL + F D RP A LLSHP++
Sbjct: 608 QMQAIFRIGENILPEFPSNISSSAIDFLEKTFAIDCNLRPTASELLSHPFV 658
>ST25_HUMAN (O00506) Serine/threonine-protein kinase 25 (EC
2.7.1.37) (Sterile 20/oxidant stress-response kinase 1)
(Ste20/oxidant stress response kinase-1) (SOK-1)
(Ste20-like kinase)
Length = 426
Score = 211 bits (537), Expect = 1e-53
Identities = 111/251 (44%), Positives = 155/251 (61%), Gaps = 4/251 (1%)
Query: 24 DEIGKGAYGRVYKGLDLENGDFVAIKQVSLENIAQEDLNIIMEMINILQNLNHKNIVKYL 83
D IGKG++G VYKG+D + VAIK + LE A++++ I + I +L + I +Y
Sbjct: 24 DRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEE-AEDEIEDIQQEITVLSQCDSPYITRYF 82
Query: 84 GSLKTKSHLHIILEYVENGSLANIIKPNKFGPFPESLVAVYIAQVLEGLVYLHEQGVIHR 143
GS + L II+EY+ GS +++KP GP E+ +A + ++L+GL YLH + IHR
Sbjct: 83 GSYLKSTKLWIIMEYLGGGSALDLLKP---GPLEETYIATILREILKGLDYLHSERKIHR 139
Query: 144 DIKGANILTTKEGLVKLADFGVATKLTEADINTHSVVGTPYWMAPEVIEMSGVCAASDIW 203
DIK AN+L +++G VKLADFGVA +LT+ I ++ VGTP+WMAPEVI+ S +DIW
Sbjct: 140 DIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKADIW 199
Query: 204 SVGCTVIELLTCVPPYYDLQPMPALFRIVQDEQPPIPDSLSPNITDFLHQCFKKDARQRP 263
S+G T IEL PP DL PM LF I ++ P + S +F+ C KD R RP
Sbjct: 200 SLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQHSKPFKEFVEACLNKDPRFRP 259
Query: 264 DAKTLLSHPWI 274
AK LL H +I
Sbjct: 260 TAKELLKHKFI 270
>CC15_YEAST (P27636) Cell division control protein 15 (EC 2.7.1.-)
Length = 974
Score = 211 bits (537), Expect = 1e-53
Identities = 118/262 (45%), Positives = 159/262 (60%), Gaps = 7/262 (2%)
Query: 19 KYMLGDEIGKGAYGRVYKGLDLENGDFVAIKQVSLENIAQEDLNIIMEMINILQNLNHKN 78
+Y L IG+G+YG VYK ++ VAIK+V EN E+LN IM I++L+NLNH N
Sbjct: 24 QYHLKQVIGRGSYGVVYKAINKHTDQVVAIKEVVYEN--DEELNDIMAEISLLKNLNHNN 81
Query: 79 IVKYLGSLKTKSHLHIILEYVENGSLANIIKPNKFGPFPESLVAVYIAQVLEGLVYLHEQ 138
IVKY G ++ L+I+LEY NGSL +I + G E+ Y+ Q L GL YLH +
Sbjct: 82 IVKYHGFIRKSYELYILLEYCANGSLRRLISRSSTG-LSENESKTYVTQTLLGLKYLHGE 140
Query: 139 GVIHRDIKGANILTTKEGLVKLADFGVATKLTEADINTHSVVGTPYWMAPEVIEMSGVCA 198
GVIHRDIK ANIL + + VKLADFGV+T + + + ++ GT WMAPE++ G
Sbjct: 141 GVIHRDIKAANILLSADNTVKLADFGVSTIVNSSAL---TLAGTLNWMAPEILGNRGAST 197
Query: 199 ASDIWSVGCTVIELLTCVPPYYDLQPMPALFRIVQDEQPPIPDSLSPNITDFLHQCFKKD 258
SDIWS+G TV+E+LT PPY++L + + D P P S S + DFL +CF K+
Sbjct: 198 LSDIWSLGATVVEMLTKNPPYHNLTDANIYYAVENDTYYP-PSSFSEPLKDFLSKCFVKN 256
Query: 259 ARQRPDAKTLLSHPWILNCRRV 280
+RP A LL H WI + V
Sbjct: 257 MYKRPTADQLLKHVWINSTENV 278
>ST25_MOUSE (Q9Z2W1) Serine/threonine-protein kinase 25 (EC
2.7.1.37) (Sterile 20/oxidant stress-response kinase 1)
(Ste20/oxidant stress response kinase-1) (SOK-1)
(Ste20-like kinase)
Length = 426
Score = 210 bits (534), Expect = 3e-53
Identities = 110/251 (43%), Positives = 155/251 (60%), Gaps = 4/251 (1%)
Query: 24 DEIGKGAYGRVYKGLDLENGDFVAIKQVSLENIAQEDLNIIMEMINILQNLNHKNIVKYL 83
D IGKG++G VYKG+D + VAIK + LE A++++ I + I +L + I +Y
Sbjct: 24 DRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEE-AEDEIEDIQQEITVLSQCDSPYITRYF 82
Query: 84 GSLKTKSHLHIILEYVENGSLANIIKPNKFGPFPESLVAVYIAQVLEGLVYLHEQGVIHR 143
GS + L II+EY+ GS +++KP GP E+ +A + ++L+GL YLH + IHR
Sbjct: 83 GSYLKSTKLWIIMEYLGGGSALDLLKP---GPLEETYIATILREILKGLDYLHSERKIHR 139
Query: 144 DIKGANILTTKEGLVKLADFGVATKLTEADINTHSVVGTPYWMAPEVIEMSGVCAASDIW 203
DIK AN+L +++G VK+ADFGVA +LT+ I ++ VGTP+WMAPEVI+ S +DIW
Sbjct: 140 DIKAANVLLSEQGDVKMADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKADIW 199
Query: 204 SVGCTVIELLTCVPPYYDLQPMPALFRIVQDEQPPIPDSLSPNITDFLHQCFKKDARQRP 263
S+G T IEL PP DL PM LF I ++ P + S +F+ C KD R RP
Sbjct: 200 SLGITAIELAKGEPPNSDLHPMRVLFLIPKNNPPTLEGHHSKPFKEFVEACLNKDPRFRP 259
Query: 264 DAKTLLSHPWI 274
AK LL H +I
Sbjct: 260 TAKELLKHKFI 270
>ST24_HUMAN (Q9Y6E0) Serine/threonine-protein kinase 24 (EC
2.7.1.37) (STE20-like kinase MST3) (MST-3) (Mammalian
STE20-like protein kinase 3)
Length = 443
Score = 206 bits (524), Expect = 4e-52
Identities = 106/252 (42%), Positives = 158/252 (62%), Gaps = 4/252 (1%)
Query: 24 DEIGKGAYGRVYKGLDLENGDFVAIKQVSLENIAQEDLNIIMEMINILQNLNHKNIVKYL 83
++IGKG++G V+KG+D VAIK + LE A++++ I + I +L + + KY
Sbjct: 40 EKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEE-AEDEIEDIQQEITVLSQCDSPYVTKYY 98
Query: 84 GSLKTKSHLHIILEYVENGSLANIIKPNKFGPFPESLVAVYIAQVLEGLVYLHEQGVIHR 143
GS + L II+EY+ GS ++++P GP E+ +A + ++L+GL YLH + IHR
Sbjct: 99 GSYLKDTKLWIIMEYLGGGSALDLLEP---GPLDETQIATILREILKGLDYLHSEKKIHR 155
Query: 144 DIKGANILTTKEGLVKLADFGVATKLTEADINTHSVVGTPYWMAPEVIEMSGVCAASDIW 203
DIK AN+L ++ G VKLADFGVA +LT+ I ++ VGTP+WMAPEVI+ S + +DIW
Sbjct: 156 DIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIW 215
Query: 204 SVGCTVIELLTCVPPYYDLQPMPALFRIVQDEQPPIPDSLSPNITDFLHQCFKKDARQRP 263
S+G T IEL PP+ +L PM LF I ++ P + + S + +F+ C K+ RP
Sbjct: 216 SLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRP 275
Query: 264 DAKTLLSHPWIL 275
AK LL H +IL
Sbjct: 276 TAKELLKHKFIL 287
>STK4_HUMAN (Q13043) Serine/threonine-protein kinase 4 (EC 2.7.1.37)
(STE20-like kinase MST1) (MST-1) (Mammalian STE20-like
protein kinase 1) (Serine/threonine-protein kinase
Krs-2)
Length = 487
Score = 205 bits (521), Expect = 8e-52
Identities = 131/349 (37%), Positives = 190/349 (53%), Gaps = 16/349 (4%)
Query: 24 DEIGKGAYGRVYKGLDLENGDFVAIKQVSLENIAQEDLNIIMEMINILQNLNHKNIVKYL 83
+++G+G+YG VYK + E G VAIKQV +E+ DL I++ I+I+Q + ++VKY
Sbjct: 34 EKLGEGSYGSVYKAIHKETGQIVAIKQVPVES----DLQEIIKEISIMQQCDSPHVVKYY 89
Query: 84 GSLKTKSHLHIILEYVENGSLANIIK-PNKFGPFPESLVAVYIAQVLEGLVYLHEQGVIH 142
GS + L I++EY GS+++II+ NK E +A + L+GL YLH IH
Sbjct: 90 GSYFKNTDLWIVMEYCGAGSVSDIIRLRNK--TLTEDEIATILQSTLKGLEYLHFMRKIH 147
Query: 143 RDIKGANILTTKEGLVKLADFGVATKLTEADINTHSVVGTPYWMAPEVIEMSGVCAASDI 202
RDIK NIL EG KLADFGVA +LT+ ++V+GTP+WMAPEVI+ G +DI
Sbjct: 148 RDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADI 207
Query: 203 WSVGCTVIELLTCVPPYYDLQPMPALFRIVQDEQPPI--PDSLSPNITDFLHQCFKKDAR 260
WS+G T IE+ PPY D+ PM A+F I + P P+ S N TDF+ QC K
Sbjct: 208 WSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPE 267
Query: 261 QRPDAKTLLSHPWILNCRRV-LQSSLRHSGTLRTIKDDGSAVAEVSGGDHKSTGEGSSVE 319
QR A LL HP++ + + V + L + +K S EV D +++ E E
Sbjct: 268 QRATATQLLQHPFVRSAKGVSILRDLINEAMDVKLKRQESQQREVDQDDEENSEED---E 324
Query: 320 KEDSAKEFSTGEANSRKSHEDNASDSNFSNERTEKEDDIPSDQVLTLAI 368
+ + G+ +D +N E +D +PS Q+ T+ I
Sbjct: 325 MDSGTMVRAVGDEMGTVRVASTMTDG--ANTMIEHDDTLPS-QLGTMVI 370
>SID1_SCHPO (O14305) Serine/threonine-protein kinase sid1 (EC
2.7.1.37) (STE20-like kinase sid1)
Length = 471
Score = 201 bits (511), Expect = 1e-50
Identities = 106/258 (41%), Positives = 156/258 (60%), Gaps = 5/258 (1%)
Query: 18 NKYMLGDEIGKGAYGRVYKGLDLENGDFVAIKQVSLENIAQEDLNIIMEMINILQNLNHK 77
N Y L ++G G++G V+K + +GD +AIKQ+ LE +D+ I + + +L N N
Sbjct: 7 NSYTLLRKLGSGSFGVVWKARENVSGDIIAIKQIDLET-GIDDITDIEQEVFMLSNCNSS 65
Query: 78 NIVKYLGSLKTKSHLHIILEYVENGSLANIIKPNKFGPFPESLVAVYIAQVLEGLVYLHE 137
N+++Y G L I++E+++ GS++ ++K G E ++++ + +VL GL YLH
Sbjct: 66 NVIQYYGCFVDGYTLWILMEHMDGGSVSGLLK---MGRLNEQVISIILREVLYGLNYLHG 122
Query: 138 QGVIHRDIKGANIL-TTKEGLVKLADFGVATKLTEADINTHSVVGTPYWMAPEVIEMSGV 196
Q IHRDIK ANIL ++ G VKLADFGVA +L+ A H+ VGTP+WMAPEVI+ +
Sbjct: 123 QNKIHRDIKAANILLSSSTGNVKLADFGVAAQLSNAASRRHTFVGTPFWMAPEVIQQTSY 182
Query: 197 CAASDIWSVGCTVIELLTCVPPYYDLQPMPALFRIVQDEQPPIPDSLSPNITDFLHQCFK 256
A+DIWS+G T IE+ +PP + PM +F I Q E P + D SP DF+ C
Sbjct: 183 GLAADIWSLGITAIEMANGIPPRATMHPMRVIFEIPQSEPPKLDDHFSPTFRDFVSCCLD 242
Query: 257 KDARQRPDAKTLLSHPWI 274
+ R AK LL HP+I
Sbjct: 243 LNPNMRWSAKELLQHPFI 260
>HPO_DROME (Q8T0S6) Serine/threonine-protein kinase hippo (EC
2.7.1.37)
Length = 669
Score = 199 bits (506), Expect = 4e-50
Identities = 127/349 (36%), Positives = 186/349 (52%), Gaps = 28/349 (8%)
Query: 5 STSSAFTKSKTLDNKYMLGD---------EIGKGAYGRVYKGLDLENGDFVAIKQVSLEN 55
S+S +F K K L + +L ++G+G+YG VYK + E+ VAIK V +E+
Sbjct: 18 SSSCSFFKLKKLSEESLLQPPEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPVES 77
Query: 56 IAQEDLNIIMEMINILQNLNHKNIVKYLGSLKTKSHLHIILEYVENGSLANIIKPNKFGP 115
DL+ I++ I+I+Q + +V+Y GS + L I +EY GS+++I++ K
Sbjct: 78 ----DLHEIIKEISIMQQCDSPYVVRYYGSYFKQYDLWICMEYCGAGSVSDIMRLRK-KT 132
Query: 116 FPESLVAVYIAQVLEGLVYLHEQGVIHRDIKGANILTTKEGLVKLADFGVATKLTEADIN 175
E +A ++ L+GLVYLH + IHRDIK ANIL EG KLADFGVA +LT+
Sbjct: 133 LTEDEIATILSDTLQGLVYLHLRRKIHRDIKAANILLNTEGYAKLADFGVAGQLTDTMAK 192
Query: 176 THSVVGTPYWMAPEVIEMSGVCAASDIWSVGCTVIELLTCVPPYYDLQPMPALFRIVQDE 235
++V+GTP+WMAPEVIE G +DIWS+G T +E+ PPY ++ PM A+F I Q
Sbjct: 193 RNTVIGTPFWMAPEVIEEIGYDCVADIWSLGITALEMAEGKPPYGEIHPMRAIFMIPQKP 252
Query: 236 QPPI--PDSLSPNITDFLHQCFKKDARQRPDAKTLLSHPWILNCRRVLQSSLRHSGTLRT 293
P PD S DF+ +C K+ R A LL H +I N +H L+
Sbjct: 253 PPSFREPDRWSTEFIDFVSKCLVKEPDDRATATELLEHEFIRNA--------KHRSILKP 304
Query: 294 IKDDGSAVAEVSGGDHKSTGEGSSVEKEDSAKEFSTGEANSRKSHEDNA 342
+ ++ A+ E + G V AK +T E ++ DNA
Sbjct: 305 MLEETCAIREQQRANRSFGG----VLAASQAKSLATQENGMQQHITDNA 349
>STK3_MOUSE (Q9JI10) Serine/threonine-protein kinase 3 (EC 2.7.1.37)
(STE20-like kinase MST2) (MST-2) (Mammalian STE20-like
protein kinase 2)
Length = 497
Score = 198 bits (503), Expect = 1e-49
Identities = 112/260 (43%), Positives = 157/260 (60%), Gaps = 9/260 (3%)
Query: 24 DEIGKGAYGRVYKGLDLENGDFVAIKQVSLENIAQEDLNIIMEMINILQNLNHKNIVKYL 83
+++G+G+YG V+K + E+G VAIKQV +E+ DL I++ I+I+Q + +VKY
Sbjct: 31 EKLGEGSYGSVFKAIHKESGQVVAIKQVPVES----DLQEIIKEISIMQQCDSPYVVKYY 86
Query: 84 GSLKTKSHLHIILEYVENGSLANIIK-PNKFGPFPESLVAVYIAQVLEGLVYLHEQGVIH 142
GS + L I++EY GS+++II+ NK E +A + L+GL YLH IH
Sbjct: 87 GSYFKNTDLWIVMEYCGAGSVSDIIRLRNK--TLTEDEIATILKSTLKGLEYLHFMRKIH 144
Query: 143 RDIKGANILTTKEGLVKLADFGVATKLTEADINTHSVVGTPYWMAPEVIEMSGVCAASDI 202
RDIK NIL EG KLADFGVA +LT+ ++V+GTP+WMAPEVI+ G +DI
Sbjct: 145 RDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADI 204
Query: 203 WSVGCTVIELLTCVPPYYDLQPMPALFRIVQDEQPPI--PDSLSPNITDFLHQCFKKDAR 260
WS+G T IE+ PPY D+ PM A+F I + P P+ S + TDF+ +C K
Sbjct: 205 WSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKSPE 264
Query: 261 QRPDAKTLLSHPWILNCRRV 280
QR A LL HP+I N + V
Sbjct: 265 QRATATQLLQHPFIKNAKPV 284
>STK3_HUMAN (Q13188) Serine/threonine-protein kinase 3 (EC 2.7.1.37)
(STE20-like kinase MST2) (MST-2) (Mammalian STE20-like
protein kinase 2) (Serine/threonine-protein kinase
Krs-1)
Length = 491
Score = 198 bits (503), Expect = 1e-49
Identities = 132/372 (35%), Positives = 199/372 (53%), Gaps = 29/372 (7%)
Query: 24 DEIGKGAYGRVYKGLDLENGDFVAIKQVSLENIAQEDLNIIMEMINILQNLNHKNIVKYL 83
+++G+G+YG V+K + E+G VAIKQV +E+ DL I++ I+I+Q + +VKY
Sbjct: 31 EKLGEGSYGSVFKAIHKESGQVVAIKQVPVES----DLQEIIKEISIMQQCDSPYVVKYY 86
Query: 84 GSLKTKSHLHIILEYVENGSLANIIK-PNKFGPFPESLVAVYIAQVLEGLVYLHEQGVIH 142
GS + L I++EY GS+++II+ NK E +A + L+GL YLH IH
Sbjct: 87 GSYFKNTDLWIVMEYCGAGSVSDIIRLRNK--TLIEDEIATILKSTLKGLEYLHFMRKIH 144
Query: 143 RDIKGANILTTKEGLVKLADFGVATKLTEADINTHSVVGTPYWMAPEVIEMSGVCAASDI 202
RDIK NIL EG KLADFGVA +LT+ ++V+GTP+WMAPEVI+ G +DI
Sbjct: 145 RDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADI 204
Query: 203 WSVGCTVIELLTCVPPYYDLQPMPALFRIVQDEQPPI--PDSLSPNITDFLHQCFKKDAR 260
WS+G T IE+ PPY D+ PM A+F I + P P+ S + TDF+ +C K+
Sbjct: 205 WSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPE 264
Query: 261 QRPDAKTLLSHPWILNCRRVL-----------QSSLRHSGTLRTIKDDGSAVAEVSGGDH 309
QR A LL HP+I N + V + RH R ++++ E H
Sbjct: 265 QRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAKRHEEQQRELEEEEENSDEDELDSH 324
Query: 310 KSTGEGSSVEKEDSAKEFSTGEANSRKSHEDNAS--DSN-----FSNERTEKEDDIPSDQ 362
T +SVE + + ST ++ E N++ +S+ ++E E+ED
Sbjct: 325 --TMVKTSVESVGTMRATSTMSEGAQTMIEHNSTMLESDLGTMVINSEDEEEEDGTMKRN 382
Query: 363 VLTLAIREKSFL 374
+ ++ SF+
Sbjct: 383 ATSPQVQRPSFM 394
>M3K3_MOUSE (Q61084) Mitogen-activated protein kinase kinase kinase
3 (EC 2.7.1.37) (MAPK/ERK kinase kinase 3) (MEK kinase
3) (MEKK 3)
Length = 626
Score = 194 bits (492), Expect = 2e-48
Identities = 110/270 (40%), Positives = 161/270 (58%), Gaps = 12/270 (4%)
Query: 11 TKSKTLDNKYMLGDEIGKGAYGRVYKGLDLENGDFVAIKQVSLENIAQEDLNIIMEM--- 67
TKS + + G +G+GA+GRVY D++ G +A KQV + + E + +
Sbjct: 353 TKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECE 412
Query: 68 INILQNLNHKNIVKYLGSLKTKSH--LHIILEYVENGSLANIIKPNKFGPFPESLVAVYI 125
I +L+NL H+ IV+Y G L+ ++ L I +EY+ GS+ + +K +G ES+ Y
Sbjct: 413 IQLLKNLQHERIVQYYGCLRDRAEKILTIFMEYMPGGSVKDQLKA--YGALTESVTRKYT 470
Query: 126 AQVLEGLVYLHEQGVIHRDIKGANILTTKEGLVKLADFGVATKLTE---ADINTHSVVGT 182
Q+LEG+ YLH ++HRDIKGANIL G VKL DFG + +L + SV GT
Sbjct: 471 RQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGIRSVTGT 530
Query: 183 PYWMAPEVIEMSGVCAASDIWSVGCTVIELLTCVPPYYDLQPMPALFRI-VQDEQPPIPD 241
PYWM+PEVI G +D+WS+GCTV+E+LT PP+ + + M A+F+I Q P +P
Sbjct: 531 PYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPS 590
Query: 242 SLSPNITDFLHQCFKKDARQRPDAKTLLSH 271
+S + DFL + F +ARQRP A+ LL+H
Sbjct: 591 HISEHGRDFLRRIF-VEARQRPSAEELLTH 619
>M3K3_HUMAN (Q99759) Mitogen-activated protein kinase kinase kinase
3 (EC 2.7.1.37) (MAPK/ERK kinase kinase 3) (MEK kinase
3) (MEKK 3)
Length = 626
Score = 194 bits (492), Expect = 2e-48
Identities = 110/270 (40%), Positives = 161/270 (58%), Gaps = 12/270 (4%)
Query: 11 TKSKTLDNKYMLGDEIGKGAYGRVYKGLDLENGDFVAIKQVSLENIAQEDLNIIMEM--- 67
TKS + + G +G+GA+GRVY D++ G +A KQV + + E + +
Sbjct: 353 TKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECE 412
Query: 68 INILQNLNHKNIVKYLGSLKTKSH--LHIILEYVENGSLANIIKPNKFGPFPESLVAVYI 125
I +L+NL H+ IV+Y G L+ ++ L I +EY+ GS+ + +K +G ES+ Y
Sbjct: 413 IQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKA--YGALTESVTRKYT 470
Query: 126 AQVLEGLVYLHEQGVIHRDIKGANILTTKEGLVKLADFGVATKLTE---ADINTHSVVGT 182
Q+LEG+ YLH ++HRDIKGANIL G VKL DFG + +L + SV GT
Sbjct: 471 RQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGT 530
Query: 183 PYWMAPEVIEMSGVCAASDIWSVGCTVIELLTCVPPYYDLQPMPALFRI-VQDEQPPIPD 241
PYWM+PEVI G +D+WS+GCTV+E+LT PP+ + + M A+F+I Q P +P
Sbjct: 531 PYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPS 590
Query: 242 SLSPNITDFLHQCFKKDARQRPDAKTLLSH 271
+S + DFL + F +ARQRP A+ LL+H
Sbjct: 591 HISEHGRDFLRRIF-VEARQRPSAEELLTH 619
>WR19_ARATH (Q9SZ67) Probable WRKY transcription factor 19 (WRKY
DNA-binding protein 19)
Length = 1895
Score = 193 bits (491), Expect = 2e-48
Identities = 114/279 (40%), Positives = 167/279 (58%), Gaps = 21/279 (7%)
Query: 5 STSSAFTKSKTLDNKYMLGDEIGKGAYGRVYKGLDLENGDFVAIKQVSLENIAQEDLNII 64
+TS + + + G +G+G+ G VY+G+ + GDF A K+VSL + + I
Sbjct: 1611 NTSPIYASEGSFITCWQKGQLLGRGSLGSVYEGISAD-GDFFAFKEVSLLDQGSQAHEWI 1669
Query: 65 MEM---INILQNLNHKNIVKYLGSLKTKSHLHIILEYVENGSLANIIKPNKFGPFPESLV 121
++ I +L L H+NIV+Y G+ K +S+L+I LE V GSL + + N+ G +S+V
Sbjct: 1670 QQVEGGIALLSQLQHQNIVRYRGTTKDESNLYIFLELVTQGSLRKLYQRNQLG---DSVV 1726
Query: 122 AVYIAQVLEGLVYLHEQGVIHRDIKGANILTTKEGLVKLADFGVATKLTEADINTHSVVG 181
++Y Q+L+GL YLH++G IHR+IK AN+L G VKLADFG+A + S+
Sbjct: 1727 SLYTRQILDGLKYLHDKGFIHRNIKCANVLVDANGTVKLADFGLAKVM--------SLWR 1778
Query: 182 TPYW--MAPEVI----EMSGVCAASDIWSVGCTVIELLTCVPPYYDLQPMPALFRIVQDE 235
TPYW MAPEVI + G +DIWS+GCTV+E+LT PY DL+ AL+ I +
Sbjct: 1779 TPYWNWMAPEVILNPKDYDGYGTPADIWSLGCTVLEMLTGQIPYSDLEIGTALYNIGTGK 1838
Query: 236 QPPIPDSLSPNITDFLHQCFKKDARQRPDAKTLLSHPWI 274
P IPD LS + DF+ C K + +RP A LL+HP++
Sbjct: 1839 LPKIPDILSLDARDFILTCLKVNPEERPTAAELLNHPFV 1877
>MKH1_SCHPO (Q10407) MAP kinase kinase kinase mkh1 (EC 2.7.1.-)
Length = 1116
Score = 187 bits (475), Expect = 2e-46
Identities = 105/286 (36%), Positives = 171/286 (59%), Gaps = 21/286 (7%)
Query: 7 SSAFTKSKTLDNKYMLGDEIGKGAYGRVYKGLDLENGDFVAIKQVSL--------ENIAQ 58
+S S+ K+M G+ IG G YG+V+ +++ G+ +A+KQV + + + +
Sbjct: 812 TSGSVVSQNATFKWMKGELIGNGTYGKVFLAMNINTGELIAVKQVEIPQTINGRHDQLRK 871
Query: 59 EDLNIIMEMINILQNLNHKNIVKYLGSLKTKSHLHIILEYVENGSLANIIKPNKFGPFPE 118
+ ++ I I+++ +L+H NIV+YLG KT++ + I LEYV GS+ ++ +GPF E
Sbjct: 872 DIVDSINAEISMIADLDHLNIVQYLGFEKTETDISIFLEYVSGGSIGRCLR--NYGPFEE 929
Query: 119 SLVAVYIAQVLEGLVYLHEQGVIHRDIKGANILTTKEGLVKLADFGV---ATKLTEADIN 175
LV QVL GL YLH +G+IHRD+K N+L +G+ K++DFG+ + + + D N
Sbjct: 930 QLVRFVSRQVLYGLSYLHSKGIIHRDLKADNLLIDFDGVCKISDFGISKHSDNVYDNDAN 989
Query: 176 THSVVGTPYWMAPEVI--EMSGVCAASDIWSVGCTVIELLTCVPPYYDLQPMPALFRI-V 232
S+ G+ +WMAPEVI + G A D+WS+GC V+E+L P+ + + A+F++
Sbjct: 990 L-SMQGSIFWMAPEVIHNDHQGYSAKVDVWSLGCVVLEMLAGRRPWSTDEAIQAMFKLGT 1048
Query: 233 QDEQPPIPDSL----SPNITDFLHQCFKKDARQRPDAKTLLSHPWI 274
+ + PPIP L SP FL+ CF +A RP A+ LL+HP++
Sbjct: 1049 EKKAPPIPSELVSQVSPEAIQFLNACFTVNADVRPTAEELLNHPFM 1094
>M4K3_RAT (Q924I2) Mitogen-activated protein kinase kinase kinase
kinase 3 (EC 2.7.1.37) (MAPK/ERK kinase kinase kinase 3)
(MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase
related protein kinase) (GLK) (Fragment)
Length = 862
Score = 186 bits (473), Expect = 3e-46
Identities = 108/262 (41%), Positives = 148/262 (56%), Gaps = 11/262 (4%)
Query: 20 YMLGDEIGKGAYGRVYKGLDLENGDFVAIKQVSLENIAQEDLNIIMEMINILQNLNHKNI 79
+ L IG G YG VYK ++ G+ AIK + LE ED ++ + I ++++ H NI
Sbjct: 5 FELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLE--PGEDFAVVQQEIIMMKDCKHANI 62
Query: 80 VKYLGSLKTKSHLHIILEYVENGSLANIIKPNKFGPFPESLVAVYIAQVLEGLVYLHEQG 139
V Y GS + L I +E+ GSL +I GP E +A + L+GL YLH +G
Sbjct: 63 VAYFGSYLRRDKLWICMEFCGGGSLQDIYHVT--GPLSELQIAYVSRETLQGLYYLHSKG 120
Query: 140 VIHRDIKGANILTTKEGLVKLADFGVATKLTEADINTHSVVGTPYWMAPEVIEM---SGV 196
+HRDIKGANIL T G VKLADFGV+ ++T S +GTPYWMAPEV + G
Sbjct: 121 KMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGY 180
Query: 197 CAASDIWSVGCTVIELLTCVPPYYDLQPMPALFRIVQDE-QPP-IPDSL--SPNITDFLH 252
D+W+VG T IEL PP +DL PM ALF + + QPP + D L S + F+
Sbjct: 181 NQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKLKWSNSFHHFVK 240
Query: 253 QCFKKDARQRPDAKTLLSHPWI 274
K+ ++RP A+ LL HP++
Sbjct: 241 MALTKNPKKRPTAEKLLQHPFV 262
>M4K5_MOUSE (Q8BPM2) Mitogen-activated protein kinase kinase kinase
kinase 5 (EC 2.7.1.37) (MAPK/ERK kinase kinase kinase 5)
(MEK kinase kinase 5) (MEKKK 5)
Length = 847
Score = 186 bits (471), Expect = 5e-46
Identities = 128/343 (37%), Positives = 176/343 (50%), Gaps = 26/343 (7%)
Query: 20 YMLGDEIGKGAYGRVYKGLDLENGDFVAIKQVSLENIAQEDLNIIMEMINILQNLNHKNI 79
Y L +G G YG VYK ++ G+ A+K + LE +D ++I + I +++ H NI
Sbjct: 20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLE--PGDDFSLIQQEIFMVKECKHCNI 77
Query: 80 VKYLGSLKTKSHLHIILEYVENGSLANIIKPNKFGPFPESLVAVYIAQVLEGLVYLHEQG 139
V Y GS ++ L I +EY GSL +I GP E +A + L+GL YLH +G
Sbjct: 78 VAYFGSYLSREKLWICMEYCGGGSLQDIYHVT--GPLSEMQIAYVCRETLQGLAYLHTKG 135
Query: 140 VIHRDIKGANILTTKEGLVKLADFGVATKLTEADINTHSVVGTPYWMAPEVIEM---SGV 196
+HRDIKGANIL T G VKLADFGVA K+T S +GTPYWMAPEV + G
Sbjct: 136 KMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGY 195
Query: 197 CAASDIWSVGCTVIELLTCVPPYYDLQPMPALFRIVQDE-QPP-IPDSL--SPNITDFLH 252
DIW+VG T IEL PP +DL PM ALF + + QPP + D S +F+
Sbjct: 196 NQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVK 255
Query: 253 QCFKKDARQRPDAKTLLSHPWILNCRRVLQSSLRHSGTLRTIKDDGSAVAEVSGGD-HKS 311
K+ ++RP A+ LL+H ++ G R + + + +VS D H
Sbjct: 256 IALTKNPKKRPTAERLLTHTFV-----------GQPGLSRALAVE--LLDKVSNPDNHAP 302
Query: 312 TGEGSSVEKEDSAKEFSTGEANSRKSH-EDNASDSNFSNERTE 353
EG + E A T + +R S E AS+ NF + E
Sbjct: 303 YSEGDEDDLEPHAIIRHTIRSTNRNSRAERTASEINFDKLQFE 345
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.315 0.132 0.371
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 160,641,553
Number of Sequences: 164201
Number of extensions: 6956987
Number of successful extensions: 27495
Number of sequences better than 10.0: 1768
Number of HSP's better than 10.0 without gapping: 1518
Number of HSP's successfully gapped in prelim test: 256
Number of HSP's that attempted gapping in prelim test: 21280
Number of HSP's gapped (non-prelim): 2642
length of query: 1406
length of database: 59,974,054
effective HSP length: 123
effective length of query: 1283
effective length of database: 39,777,331
effective search space: 51034315673
effective search space used: 51034315673
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 72 (32.3 bits)
Lotus: description of TM0135.8