BLASTP 2.2.2 [Dec-14-2001]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= TM0105.17
         (488 letters)

Database: sprot 
           164,201 sequences; 59,974,054 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

KG88_MOUSE (P59281) Protein KIAA1688 homolog (Fragment)                70  2e-11
KG88_HUMAN (Q9C0H5) Protein KIAA1688                                   70  2e-11
RGA2_SCHPO (Q10164) Probable Rho-type GTPase-activating protein 2      67  1e-10
RHG8_HUMAN (Q9NSG0) Rho-GTPase-activating protein 8 (PP610)            60  1e-08
RBP1_MOUSE (Q62172) RalA binding protein 1 (RalBP1) (Ral interac...    59  2e-08
RBP1_RAT (Q62796) RalA binding protein 1 (RalBP1) (Ral interacti...    59  3e-08
GAP_CAEEL (P34288) GTPase-activating protein GAP (CeGAP)               59  3e-08
RHG8_MOUSE (Q9CXP4) Rho-GTPase-activating protein 8                    57  8e-08
BEM3_YEAST (P32873) GTPase-activating protein BEM3                     57  1e-07
RHG1_HUMAN (Q07960) Rho-GTPase-activating protein 1 (GTPase-acti...    56  2e-07
BEM3_ASHGO (Q74ZH7) GTPase-activating protein BEM3                     54  7e-07
RBP1_HUMAN (Q15311) RalA binding protein 1 (RalBP1) (Ral interac...    54  1e-06
RGA3_SCHPO (O14014) Probable Rho-type GTPase-activating protein 3      53  2e-06
YLE5_CAEEL (P46941) Hypothetical protein C38D4.5 in chromosome III     53  2e-06
RH25_MOUSE (Q8BYW1) Rho-GTPase-activating protein 25                   52  3e-06
RH25_HUMAN (P42331) Rho-GTPase-activating protein 25                   52  3e-06
CE05_MOUSE (Q8K2H3) Protein C5orf5 homolog                             51  6e-06
CHIO_RAT (Q03070) Beta-chimaerin (Beta-chimerin) (Rho-GTPase-act...    50  1e-05
FNB2_HUMAN (O75044) Formin binding protein 2 (srGAP2)                  50  2e-05
CHIO_HUMAN (P52757) Beta-chimaerin (Beta-chimerin) (Rho-GTPase-a...    49  2e-05

>KG88_MOUSE (P59281) Protein KIAA1688 homolog (Fragment)
          Length = 1097

 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 53/188 (28%), Positives = 89/188 (47%), Gaps = 8/188 (4%)

Query: 155  SAKVFGVSAKSMQCSYDER--GNSVPTILLMMQNRLYSEGGLKAEGIFRINADNSQEEFV 212
            S  +FG + + +     ER     +P +   +   + +  G + EGIFR+  D  +   +
Sbjct: 898  SPSMFGSALQEVMSMQKERYPDRQLPWVQTRLSEEVLALNGDQTEGIFRVPGDIDEVNAL 957

Query: 213  RCQLNRGLVPRGVE-VHCLSGLIKAWFRELPTGVLDSLTPEQ-VMHCNSEEDCTNLVKLL 270
            + Q+++  VP G+E  H  + L+K W+REL   ++     EQ + H  S E    +V  L
Sbjct: 958  KLQVDQWKVPTGLEDPHVPASLLKLWYRELEEPLIPHEFYEQCIAHYESPEAAVAVVHAL 1017

Query: 271  PSTEAALLDWAINLMADVVE--HEQFNKMNARNIAMVFAPN--MTQMVDPLTALIHAVQV 326
            P     +L + I  +   V+  +    KM+  N+AMV APN    Q  DP     +  + 
Sbjct: 1018 PRINRMVLCYLIRFLQVFVQPANVAITKMDVSNLAMVMAPNCLRCQSDDPRVIFENTRKE 1077

Query: 327  MNFLKTLI 334
            M+FL+ LI
Sbjct: 1078 MSFLRVLI 1085


>KG88_HUMAN (Q9C0H5) Protein KIAA1688
          Length = 1083

 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 60/220 (27%), Positives = 98/220 (44%), Gaps = 28/220 (12%)

Query: 121  EVRHVSHVTFDRFNGFLGLPTELQPEVPQKVPSASAKVFGVSAKSMQCSYDERGNSVPTI 180
            E+RH  +  F                 P    SA  +V G+  +     Y ER   +P +
Sbjct: 874  EIRHAKNAVFS----------------PSMFGSALQEVMGMQRER----YPER--QLPWV 911

Query: 181  LLMMQNRLYSEGGLKAEGIFRINADNSQEEFVRCQLNRGLVPRGVE-VHCLSGLIKAWFR 239
               +   + +  G + EGIFR+  D  +   ++ Q+++  VP G+E  H  + L+K W+R
Sbjct: 912  QTRLSEEVLALNGDQTEGIFRVPGDIDEVNALKLQVDQWKVPTGLEDPHVPASLLKLWYR 971

Query: 240  ELPTGVLDSLTPEQ-VMHCNSEEDCTNLVKLLPSTEAALLDWAINLMADVVE--HEQFNK 296
            EL   ++     EQ + H +S E    +V  LP     +L + I  +   V+  +    K
Sbjct: 972  ELEEPLIPHEFYEQCIAHYDSPEAAVAVVHALPRINRMVLCYLIRFLQVFVQPANVAVTK 1031

Query: 297  MNARNIAMVFAPN--MTQMVDPLTALIHAVQVMNFLKTLI 334
            M+  N+AMV APN    Q  DP     +  + M+FL+ LI
Sbjct: 1032 MDVSNLAMVMAPNCLRCQSDDPRVIFENTRKEMSFLRVLI 1071


>RGA2_SCHPO (Q10164) Probable Rho-type GTPase-activating protein 2
          Length = 1275

 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 52/202 (25%), Positives = 92/202 (44%), Gaps = 14/202 (6%)

Query: 134  NGFLGLPTELQPEVPQKVPSASAKVFGVSA-KSMQCSYDERGNSVPTILLMMQNRLYSEG 192
            N  L   +    E  QK     + +FG+   +++  S     + +P ++      L S  
Sbjct: 1038 NVMLSPSSTTSAEPLQKHIVRKSGIFGLPLNEAVNISTQFNDSGLPIVVYRCIEYLESCR 1097

Query: 193  GLKAEGIFRINADNSQEEFVRCQLNRGL------VPRGVEVHCLSGLIKAWFRELPTGVL 246
              K EGI+R++   S  + ++ Q N G+           +VH ++GL+K + R LPT +L
Sbjct: 1098 AEKEEGIYRLSGSASTIKHLKEQFNEGVDYDLLSSDEEFDVHVIAGLLKLYLRNLPTNLL 1157

Query: 247  DS-------LTPEQVMHCNSEEDCTNLVKLLPSTEAALLDWAINLMADVVEHEQFNKMNA 299
            D+       L P       +  +  +++  LP    ALLD  ++ +  ++  E+ NKMN 
Sbjct: 1158 DTSMHKLFELLPNVPNDSAALGELCDVISKLPPENFALLDSLLHHLRRIIAFEKVNKMNI 1217

Query: 300  RNIAMVFAPNMTQMVDPLTALI 321
            RN+ +VF+P +    D    LI
Sbjct: 1218 RNVCIVFSPTLNIPSDIFMMLI 1239


>RHG8_HUMAN (Q9NSG0) Rho-GTPase-activating protein 8 (PP610)
          Length = 718

 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 50/188 (26%), Positives = 86/188 (45%), Gaps = 15/188 (7%)

Query: 146 EVPQKVPSASAKVFGVSAKSMQCSYDERGNSVPTILLMMQNRLYSEGGLKAEGIFRINAD 205
           + P   P    + FGVS + ++     +G  +P +L      L  E GL+ EG+FR +A 
Sbjct: 465 KTPPPRPPLPTQQFGVSLQYLKDK--NQGELIPPVLRFTVTYL-REKGLRTEGLFRRSAS 521

Query: 206 NSQEEFVRCQLNRGLVPRGVE---VHCLSGLIKAWFRELPTGVLDSLTPEQVMHCNSEED 262
                 ++   N+G      +   +H  + ++K + RELP  +L     EQ++     E 
Sbjct: 522 VQTVREIQRLYNQGKPVNFDDYGDIHIPAVILKTFLRELPQPLLTFQAYEQILGITCVES 581

Query: 263 ------CTNLVKLLPSTEAALLDWAINLMADVVEHEQFNKMNARNIAMVFAPNM---TQM 313
                 C  +++ LP     +L + +  +  V     FNKMN+ N+A VF  N+   +Q 
Sbjct: 582 SLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQG 641

Query: 314 VDPLTALI 321
           V  L+AL+
Sbjct: 642 VSSLSALV 649


>RBP1_MOUSE (Q62172) RalA binding protein 1 (RalBP1) (Ral
           interacting protein 1) (Dinitrophenyl S-glutathione
           ATPase) (DNP-SG ATPase)
          Length = 647

 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 52/205 (25%), Positives = 91/205 (44%), Gaps = 17/205 (8%)

Query: 144 QPEVPQKVPSASAKVFGV---SAKSMQCSYDERGNSVPTILLMMQNRLYSEGGLKAEGIF 200
           +PEVPQ    +   +FGV    A      YD  G  +P +     + +  + G+K EG++
Sbjct: 174 EPEVPQMDAPSVKPIFGVPLVDAVERTMMYD--GVRLPAVFRECVDYM-EKHGMKCEGVY 230

Query: 201 RINADNSQEEFVRCQLNRGLVPR--GVEVHCLSGLIKAWFRELPTGVLDS-LTPEQVMHC 257
           R++   S+ + ++   +R   P     E + ++ L+K + R+LP  +L   L P     C
Sbjct: 231 RVSGIKSKVDELKAAYDREESPNLEEYEPNTVASLLKQYLRDLPENLLTKELMPRFEEAC 290

Query: 258 NSE------EDCTNLVKLLPSTEAALLDWAINLMADVVEHEQFNKMNARNIAMVFAPNMT 311
                    ++   L++ LP     LL W I  +  V+  E   KMN +NI++V +P  T
Sbjct: 291 GKTTEMEKVQEFQRLLRELPECNHLLLSWLIVHLDHVIAKELETKMNIQNISIVLSP--T 348

Query: 312 QMVDPLTALIHAVQVMNFLKTLILK 336
             +      +    V     T++LK
Sbjct: 349 VQISNRVLYVLFTHVQELFGTVVLK 373


>RBP1_RAT (Q62796) RalA binding protein 1 (RalBP1) (Ral interacting
           protein 1) (Cytocentrin) (Dinitrophenyl S-glutathione
           ATPase) (DNP-SG ATPase)
          Length = 646

 Score = 58.9 bits (141), Expect = 3e-08
 Identities = 53/207 (25%), Positives = 95/207 (45%), Gaps = 14/207 (6%)

Query: 140 PTELQPEVPQKVPSASAKVFGVS-AKSMQCSYDERGNSVPTILLMMQNRLYSEGGLKAEG 198
           PT+ +PEVPQ    +   +FG   A +++ +    G  +P +     + +  + G+K EG
Sbjct: 171 PTQ-EPEVPQTDAPSLRPIFGAPFADAVERTMMYDGIRLPAVFRECVDYM-EKHGMKCEG 228

Query: 199 IFRINADNSQEEFVRCQLNRGLVPR--GVEVHCLSGLIKAWFRELPTGVLDS-LTPEQVM 255
           I+R++   S+ + ++   +R   P     E + ++ L+K + R+LP  +L   L P    
Sbjct: 229 IYRVSGIKSKVDELKAAYDREESPNLEEYEPNTVASLLKQYLRDLPENLLTKELMPRFEE 288

Query: 256 HCNSE------EDCTNLVKLLPSTEAALLDWAINLMADVVEHEQFNKMNARNIAMVFAPN 309
            C         ++   L++ LP     LL W I  M  V+  E   KMN +NI++V +P 
Sbjct: 289 ACGRTTEVEKVQEFQRLLRELPEYNHLLLSWLIVHMDHVIAKELETKMNIQNISIVLSP- 347

Query: 310 MTQMVDPLTALIHAVQVMNFLKTLILK 336
            T  +      +    V     T++LK
Sbjct: 348 -TVQISNRVLYVLFTHVQELFGTVLLK 373


>GAP_CAEEL (P34288) GTPase-activating protein GAP (CeGAP)
          Length = 1317

 Score = 58.9 bits (141), Expect = 3e-08
 Identities = 50/173 (28%), Positives = 81/173 (45%), Gaps = 21/173 (12%)

Query: 193 GLKAEGIFRINADNSQEEFVRCQL-NRG-----------LVPRGVEVHCLSGLIKAWFRE 240
           G+   GI+RI  + +    ++  L NRG           L PR  +V+ +S L+K + R+
Sbjct: 689 GMDTVGIYRIPGNTAAVNALKESLSNRGFDSVDLSKVESLDPRWRDVNVVSSLLKMFLRK 748

Query: 241 LPTGVL-DSLTPEQV------MHCNSEEDCTNLVKLLPSTEAALLDWAINLMADVVEHEQ 293
           LP  +L D L P  +       H N      NL++ LP      L + I  ++++ +H  
Sbjct: 749 LPEPLLTDKLYPFFIDANRISTHHNRLHKLRNLLRKLPRPHYDTLRFLIVHLSEITKHSD 808

Query: 294 FNKMNARNIAMVFAPNMTQMVDP--LTALIHAVQVMNFLKTLILKTLRERDES 344
            NKM  RN+A++F P++ +  D    T + H       ++TLI   L   DES
Sbjct: 809 VNKMECRNLALMFGPSIVRPSDDNMATMVTHMSDQCKIIETLIHYNLWMFDES 861


>RHG8_MOUSE (Q9CXP4) Rho-GTPase-activating protein 8
          Length = 425

 Score = 57.4 bits (137), Expect = 8e-08
 Identities = 54/194 (27%), Positives = 90/194 (45%), Gaps = 19/194 (9%)

Query: 144 QPEVPQKVPSASAKV----FGVSAKSMQCSYDERGNSVPTILLMMQNRLYSEGGLKAEGI 199
           QP  P K P     +    FGVS + ++     +G  +P +L      L  E GL+ EG+
Sbjct: 174 QPPPPTKTPPPRPPLPTQQFGVSLQYLRDK--NQGELIPPVLRWTVTYL-REKGLRTEGL 230

Query: 200 FRINADNSQEEFVRCQLNRGLVPRGVE---VHCLSGLIKAWFRELPTGVLDSLTPEQVMH 256
           FR +A       V+   ++G      +   +H  + ++K + RELP  +L     EQ++ 
Sbjct: 231 FRRSASAQTVRQVQRLYDQGKPVNFDDYGDMHLPAVILKTFLRELPQPLLTFQAYEQILG 290

Query: 257 CNSEED------CTNLVKLLPSTEAALLDWAINLMADVVEHEQFNKMNARNIAMVFAPNM 310
             S E       C  +++ LP    A+L + +  + +V      NKMN+ N+A VF  N+
Sbjct: 291 ITSVESSLRVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVFGLNL 350

Query: 311 ---TQMVDPLTALI 321
              +Q V  L+AL+
Sbjct: 351 IWPSQGVASLSALV 364


>BEM3_YEAST (P32873) GTPase-activating protein BEM3
          Length = 1128

 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 52/203 (25%), Positives = 95/203 (46%), Gaps = 33/203 (16%)

Query: 152  PSASAKVFGVSAKS-MQCSYDERGN--SVPTILLMMQNRLYSEGGLKAEGIFRINADNS- 207
            P  S  +FG S ++ ++ S  +  N   +P+++      LY   G++ EGIFR++  ++ 
Sbjct: 898  PHVSTAIFGSSLETCLRLSSHKYQNVYDLPSVVYRCLEYLYKNRGIQEEGIFRLSGSSTV 957

Query: 208  ----QEEFVR------CQLNRGLVPRGVE--------VHCLSGLIKAWFRELPT---GVL 246
                QE F +      C+ N  +  +  E        V+ +SGL+K + R+LP    G  
Sbjct: 958  IKTLQERFDKEYDVDLCRYNESIEAKDDEASPSLYIGVNTVSGLLKLYLRKLPHLLFGDE 1017

Query: 247  DSLTPEQVMHCNSEEDCT------NLVK--LLPSTEAALLDWAINLMADVVEHEQFNKMN 298
              L+ ++V+  N             L++  L+P    +L+     L+  + E+ +FNKMN
Sbjct: 1018 QFLSFKRVVDENHNNPVQISLGFKELIESGLVPHANLSLMYALFELLVRINENSKFNKMN 1077

Query: 299  ARNIAMVFAPNMTQMVDPLTALI 321
             RN+ +VF+P +   +  L   I
Sbjct: 1078 LRNLCIVFSPTLNIPISMLQPFI 1100


>RHG1_HUMAN (Q07960) Rho-GTPase-activating protein 1
           (GTPase-activating protein rhoOGAP) (Rho-related small
           GTPase protein activator) (CDC42 GTPase-activating
           protein) (p50-rhoGAP)
          Length = 439

 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 52/205 (25%), Positives = 89/205 (43%), Gaps = 14/205 (6%)

Query: 140 PTELQPEVPQKVPSASAKVFGVSAKSMQCSYDERGNSVPTILLMMQNRLYSEG-GLKAEG 198
           P      +P + P  + + FGVS + +Q   ++     P  +++ +   Y +   L  EG
Sbjct: 224 PATAPKPMPPRPPLPNQQ-FGVSLQHLQ---EKNPEQEPIPIVLRETVAYLQAHALTTEG 279

Query: 199 IFRINADNSQEEFVRCQLNRGL---VPRGVEVHCLSGLIKAWFRELPTGVLD-SLTPEQV 254
           IFR +A+      V+ + N GL     +  E+H  + ++K + RELP  +L   L P  V
Sbjct: 280 IFRRSANTQVVREVQQKYNMGLPVDFDQYNELHLPAVILKTFLRELPEPLLTFDLYPHVV 339

Query: 255 MHCNSEED-----CTNLVKLLPSTEAALLDWAINLMADVVEHEQFNKMNARNIAMVFAPN 309
              N +E         +++ LP     +L +    +  +  H   NKM   N+A+VF PN
Sbjct: 340 GFLNIDESQRVPATLQVLQTLPEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAVVFGPN 399

Query: 310 MTQMVDPLTALIHAVQVMNFLKTLI 334
           +    D    L     +  F K L+
Sbjct: 400 LLWAKDAAITLKAINPINTFTKFLL 424


>BEM3_ASHGO (Q74ZH7) GTPase-activating protein BEM3
          Length = 1013

 Score = 54.3 bits (129), Expect = 7e-07
 Identities = 51/200 (25%), Positives = 94/200 (46%), Gaps = 38/200 (19%)

Query: 158 VFGVSAKS--MQCSYDERGN-SVPTILLMMQNRLYSEGGLKAEGIFRINADNS-----QE 209
           VFG   +S     S+  +G   +P+++      LY   G++ EGIFR++  +S     QE
Sbjct: 790 VFGADLRSCLQLSSHPYQGKYEIPSVVFRTLEFLYKNRGIQEEGIFRLSGSSSLIKSLQE 849

Query: 210 EFVR------CQLNRGL-VPRG--------VEVHCLSGLIKAWFRELPTGVLDS---LTP 251
           +F +      C  N  + V  G        V+V+ +SGL+K + R+LP  +      +  
Sbjct: 850 QFDKEYDVDLCNYNDKVSVTPGNENQGGLYVDVNTVSGLLKLYLRKLPHMIFGDAAYMDF 909

Query: 252 EQVMHCNSEEDCTNLVKL----------LPSTEAALLDWAINLMADVVEHEQFNKMNARN 301
           ++++  N ++  + L+ L          +     AL+     L+  + E+ ++NKMN RN
Sbjct: 910 KRIVERNGDD--SKLIALEFRALVNSGRIAKEYVALMYALFELLVKITENSKYNKMNLRN 967

Query: 302 IAMVFAPNMTQMVDPLTALI 321
           + +VF+P +   V+ L   I
Sbjct: 968 LCIVFSPTLNIPVNILHPFI 987


>RBP1_HUMAN (Q15311) RalA binding protein 1 (RalBP1) (Ral
           interacting protein 1) (76-kDa Ral-interacting protein)
           (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase)
          Length = 654

 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 49/203 (24%), Positives = 90/203 (44%), Gaps = 13/203 (6%)

Query: 144 QPEVPQKVPSASAKVFGVS-AKSMQCSYDERGNSVPTILLMMQNRLYSEGGLKAEGIFRI 202
           +PEVPQ        +FG+  A +++ +    G  +P +     + +  + G+K EGI+R+
Sbjct: 174 EPEVPQIDVPNLKPIFGIPLADAVERTMMYDGIRLPAVFRECIDYV-EKYGMKCEGIYRV 232

Query: 203 NADNSQEEFVRCQLNR--GLVPRGVEVHCLSGLIKAWFRELPTGVLDS-LTPEQVMHCNS 259
           +   S+ + ++   +R         E + ++ L+K + R+LP  +L   L P     C  
Sbjct: 233 SGIKSKVDELKAAYDREESTNLEDYEPNTVASLLKQYLRDLPENLLTKELMPRFEEACGR 292

Query: 260 E------EDCTNLVKLLPSTEAALLDWAINLMADVVEHEQFNKMNARNIAMVFAPNMTQM 313
                  ++   L+K LP     L+ W I  M  V+  E   KMN +NI++V +P  T  
Sbjct: 293 TTETEKVQEFQRLLKELPECNYLLISWLIVHMDHVIAKELETKMNIQNISIVLSP--TVQ 350

Query: 314 VDPLTALIHAVQVMNFLKTLILK 336
           +      +    V      ++LK
Sbjct: 351 ISNRVLYVFFTHVQELFGNVVLK 373


>RGA3_SCHPO (O14014) Probable Rho-type GTPase-activating protein 3
          Length = 969

 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 42/178 (23%), Positives = 86/178 (47%), Gaps = 16/178 (8%)

Query: 145 PEVPQKVP--SASAKVFGVSAKSMQCSYDERGNSVPTILLMMQNRLYSEGGLKAEGIFRI 202
           PE+P ++P    S  +FG   +S++      G+ +P ++ M  + + + G L+ EGI+RI
Sbjct: 762 PEMPTRMPPPGPSPTMFG---RSLENQLKIEGSVLPQVIAMCVSCVDAHG-LEVEGIYRI 817

Query: 203 NADNSQEEFVRCQLNRGLVPRG---VEVHCLSGLIKAWFRELPTGVLDSLTPEQVMHCNS 259
           +   SQ   +  +   G +       ++   + ++K +   LP  V+     E+++    
Sbjct: 818 SGSASQVRVLVDEFENGSIRMEHLTSDLFACTSVLKTYLHRLPEPVIPGTQYEELLEAEK 877

Query: 260 ----EEDCTNLVKLLPSTEAALLD---WAINLMADVVEHEQFNKMNARNIAMVFAPNM 310
               EE    +V+++ +   A L    + I  +  V +H + N MN++N++ VFAP +
Sbjct: 878 IEKEEEKIERVVEVMKTLHPAHLSVFRFLIAHLGRVCKHAEKNLMNSKNVSTVFAPTL 935


>YLE5_CAEEL (P46941) Hypothetical protein C38D4.5 in chromosome III
          Length = 837

 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 40/163 (24%), Positives = 73/163 (44%), Gaps = 14/163 (8%)

Query: 158 VFGVSAKSMQCSYDERGNSVPTILLMMQNRLYSEGGLKAEGIFRINADNSQEEFVRCQLN 217
           VFG S  S  C ++   NS+    + +   +    GL+ +GI+R++ + S  + +RCQ +
Sbjct: 607 VFG-STLSAICQHE---NSLVPKFIRVITEVIESKGLETDGIYRVSGNLSAVQKIRCQAD 662

Query: 218 RGLVPRGV---EVHCLSGLIKAWFRELPTGVLDSLTPEQVMHCNSEEDCTN-------LV 267
           +      V   ++H L+G +K +FREL   +      ++        + T        L+
Sbjct: 663 QDNYKALVSEEDIHVLTGALKLFFRELTDPLFPISLHKEYTSAMQMPNATTRFKKFEELL 722

Query: 268 KLLPSTEAALLDWAINLMADVVEHEQFNKMNARNIAMVFAPNM 310
             LP+     L   +  +  V  H   N+M   N+A+VF P +
Sbjct: 723 SRLPNENRETLKMLLRHLNRVASHSSQNRMQQHNLAIVFGPTL 765


>RH25_MOUSE (Q8BYW1) Rho-GTPase-activating protein 25
          Length = 648

 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 48/224 (21%), Positives = 93/224 (41%), Gaps = 20/224 (8%)

Query: 155 SAKVFGVSAKSMQCSYDERGNSVPTILLMMQNRLYSEGGLKAEGIFRINADNSQEEFVRC 214
           S  VFG           + G  +  IL+        E G+  EGIFR+   ++  + +R 
Sbjct: 154 SGAVFGQRLDETVAYEQKFGPHLVPILVEKCAEFILEHGVSEEGIFRLPGQDNLVKQLRD 213

Query: 215 QLNRGLVP---RGVEVHCLSGLIKAWFRELPTGVLDSLTPEQVMHC---------NSEED 262
             + G  P   R  +VH ++ L+K + R+LP  V+     E  + C          ++++
Sbjct: 214 AFDAGERPSFDRDTDVHTVASLLKLYLRDLPEPVVPWSQYEGFLLCGQLMNADEAKAQQE 273

Query: 263 CTNLVKLLPSTEAALLDWAINLMADVVEHEQFNKMNARNIAMVFAPNM--TQMVDPLTAL 320
               +  LP     LL +    + ++  +   NKM+  N+A V   N+  +++ DP   +
Sbjct: 274 LVKQLSTLPRDNYNLLSYICRFLHEIQLNCAVNKMSVDNLATVIGVNLIRSKVEDPAVIM 333

Query: 321 IHAVQVMNFLKTLILKTLRERDESMAKARQLSSLLNSPSCKGDS 364
               Q+   +  +I      RD  +   +   + ++ P+ K D+
Sbjct: 334 RGTPQIQRVMTMMI------RDHEVLFPKSKDAPISPPAQKNDA 371


>RH25_HUMAN (P42331) Rho-GTPase-activating protein 25
          Length = 638

 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 49/229 (21%), Positives = 94/229 (40%), Gaps = 20/229 (8%)

Query: 149 QKVPSASAKVFGVSAKSMQCSYDERGNSVPTILLMMQNRLYSEGGLKAEGIFRINADNSQ 208
           ++V      VFG           + G  +  IL+        E G   EGIFR+   ++ 
Sbjct: 140 RRVAGTPCGVFGQRLDETVAYEQKFGPHLVPILVEKCAEFILEHGRNEEGIFRLPGQDNL 199

Query: 209 EEFVRCQLNRGLVP---RGVEVHCLSGLIKAWFRELPTGVLDSLTPEQVMHCN------- 258
            + +R   + G  P   R  +VH ++ L+K + R+LP  V+     E  + C        
Sbjct: 200 VKQLRDAFDAGERPSFDRDTDVHTVASLLKLYLRDLPEPVVPWSQYEGFLLCGQLTNADE 259

Query: 259 --SEEDCTNLVKLLPSTEAALLDWAINLMADVVEHEQFNKMNARNIAMVFAPNM--TQMV 314
             ++++    + +LP    +LL +    + ++  +   NKM+  N+A V   N+  +++ 
Sbjct: 260 AKAQQELMKQLSILPRDNYSLLSYICRFLHEIQLNCAVNKMSVDNLATVIGVNLIRSKVE 319

Query: 315 DPLTALIHAVQVMNFLKTLILKTLRERDESMAKARQLSSLLNSPSCKGD 363
           DP   +    Q+   +  +I      RD  +   +     L+ P+ K D
Sbjct: 320 DPAVIMRGTPQIQRVMTMMI------RDHEVLFPKSKDIPLSPPAQKND 362


>CE05_MOUSE (Q8K2H3) Protein C5orf5 homolog
          Length = 851

 Score = 51.2 bits (121), Expect = 6e-06
 Identities = 53/248 (21%), Positives = 112/248 (44%), Gaps = 18/248 (7%)

Query: 155 SAKVFGVSAKSMQCSYDERGNSVPTILLMMQNRLYSEGGLKAEGIFRINADNSQEEFVRC 214
           ++K+FG+    +Q       N VP I+  + + +   GGL+ +G+F++N +    E++R 
Sbjct: 17  ASKIFGIPLDELQQG-GHPDNEVPFIVRHVVDYIEEHGGLEQQGLFQVNGNAETVEWLRQ 75

Query: 215 QLNRGL---VPRGVEVHCLSGLIKAWFRELPTGVLDSLTPEQVMHC----NSEEDCTN-- 265
           + + G    + +  +V     L++ + +ELP  V+       ++      N+E++     
Sbjct: 76  RYDSGEEVDLVKEADVPSAISLLRFFLQELPEPVIPGSLHIHLLQLSQDYNNEDEFGRKL 135

Query: 266 --LVKLLPSTEAALLDWAINLMADVVEHEQFNKMNARNIAMVFAPNMTQMVDPLTALIHA 323
             L++ LP    +LL +    +A+V  H +    +A ++A VF P++  +   +  +   
Sbjct: 136 RFLLQQLPPVNYSLLKFLCRFLANVASHHE-EIWSANSLAAVFGPDVFHIYTDVEDMKEQ 194

Query: 324 VQVMNFLKTLILKTLR--ERDESMAKARQLSSL---LNSPSCKGDSHPFKDNREESSAQP 378
             V   +  L+       E +E    +  LSS+   +N  S + +     ++ EE   + 
Sbjct: 195 EIVSRIMAGLLENYYEFFENEEEDFSSNDLSSITEQVNELSEEEEEDEKLEHIEELPEEG 254

Query: 379 VDTCATMP 386
           V+  A MP
Sbjct: 255 VEKSAGMP 262


>CHIO_RAT (Q03070) Beta-chimaerin (Beta-chimerin)
           (Rho-GTPase-activating protein 3)
          Length = 295

 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 43/164 (26%), Positives = 81/164 (49%), Gaps = 16/164 (9%)

Query: 193 GLKAEGIFRINADNSQEEFVRCQLNRGLVPRGV------EVHCLSGLIKAWFRELPTGVL 246
           GLK+EG++R++      E V+   +R      +      +++ ++G +K +FR+LP  ++
Sbjct: 132 GLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANIYPDINIITGALKLYFRDLPIPII 191

Query: 247 --DSLTP--EQVMHCNSEEDCT---NLVKLLPSTEAALLDWAINLMADVVEHEQFNKMNA 299
             D+ T   E     N++E       ++ LLP      L + +  +  V  +E+ N MNA
Sbjct: 192 TYDTYTKFIEAAKISNADERLEAVHEVLMLLPPAHYETLRYLMIHLKKVTMNEKDNLMNA 251

Query: 300 RNIAMVFAPNMTQMVDPLTALIHAVQVMNFLKTLILKTLRERDE 343
            N+ +VF P  T M  P  + +  +  M + K LI++ L E ++
Sbjct: 252 ENLGIVFGP--TLMRPPEDSTLTTLHDMRYQK-LIVQILIENED 292


>FNB2_HUMAN (O75044) Formin binding protein 2 (srGAP2)
          Length = 1071

 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 54/252 (21%), Positives = 116/252 (45%), Gaps = 38/252 (15%)

Query: 157 KVFGVSAKSMQCSYDERGNSV------PTILLMMQN--RLYSEGGLKAEGIFRINADNSQ 208
           K  G S ++  CS   R ++V        I L++++  R  S  GL+ EGIFR++    +
Sbjct: 476 KTLGESQRT-DCSLARRSSTVRKQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVE 534

Query: 209 EEFVRCQLNRGLVP-----RGVEVHCLSGLIKAWFRELPTGVLDSLTPEQVMH----C-- 257
              ++    RG  P        ++  ++G++K +FR    G+   L P+ + H    C  
Sbjct: 535 VNDIKNAFERGEDPLAGDQNDHDMDSIAGVLKLYFR----GLEHPLFPKDIFHDLMACVT 590

Query: 258 --NSEEDCTNLVKLL---PSTEAALLDWAINLMADVVEHEQFNKMNARNIAMVFAPNMTQ 312
             N +E   ++ K+L   P T   ++ +    +  + +  + N M+  N+A+ F P++  
Sbjct: 591 MDNLQERALHIRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMS 650

Query: 313 MVDPLTALIHAVQVMNFLKTLILK------TLRERDESM-AKARQLSSLLNSPSCKGDSH 365
           + +    +     V   +KT+I++      + RE +  + ++   +    +SP   G++ 
Sbjct: 651 VPEGHDQVSCQAHVNELIKTIIIQHENIFPSPRELEGPVYSRGGSMEDYCDSP--HGETT 708

Query: 366 PFKDNREESSAQ 377
           P +D+ ++ +A+
Sbjct: 709 PVEDSTQDVTAE 720


>CHIO_HUMAN (P52757) Beta-chimaerin (Beta-chimerin)
           (Rho-GTPase-activating protein 3)
          Length = 468

 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 42/164 (25%), Positives = 80/164 (48%), Gaps = 16/164 (9%)

Query: 193 GLKAEGIFRINADNSQEEFVRCQLNRGLVPRGV------EVHCLSGLIKAWFRELPTGVL 246
           GLK+EG++R++      E V+   +R      +      +++ ++G +K +FR+LP  V+
Sbjct: 305 GLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANVYPDINIITGALKLYFRDLPIPVI 364

Query: 247 DSLTPEQVMHC----NSEEDCT---NLVKLLPSTEAALLDWAINLMADVVEHEQFNKMNA 299
              T  + +      N++E       ++ LLP      L + +  +  V  +E+ N MNA
Sbjct: 365 TYDTYSKFIDAAKISNADERLEAVHEVLMLLPPAHYETLRYLMIHLKKVTMNEKDNFMNA 424

Query: 300 RNIAMVFAPNMTQMVDPLTALIHAVQVMNFLKTLILKTLRERDE 343
            N+ +VF P  T M  P  + +  +  M + K LI++ L E ++
Sbjct: 425 ENLGIVFGP--TLMRPPEDSTLTTLHDMRYQK-LIVQILIENED 465


  Database: sprot
    Posted date:  Nov 25, 2004 10:54 AM
  Number of letters in database: 59,974,054
  Number of sequences in database:  164,201
  
Lambda     K      H
   0.314    0.132    0.391 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 61,904,019
Number of Sequences: 164201
Number of extensions: 2876287
Number of successful extensions: 30609
Number of sequences better than 10.0: 540
Number of HSP's better than 10.0 without gapping: 425
Number of HSP's successfully gapped in prelim test: 123
Number of HSP's that attempted gapping in prelim test: 19409
Number of HSP's gapped (non-prelim): 4451
length of query: 488
length of database: 59,974,054
effective HSP length: 114
effective length of query: 374
effective length of database: 41,255,140
effective search space: 15429422360
effective search space used: 15429422360
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 68 (30.8 bits)