BLASTP 2.2.2 [Dec-14-2001]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= TM0104.2
         (456 letters)

Database: sprot 
           164,201 sequences; 59,974,054 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

NTPA_PEA (P52914) Nucleoside-triphosphatase (EC 3.6.1.15) (Nucle...   648  0.0
APY_SOLTU (P80595) Apyrase precursor (EC 3.6.1.5) (ATP-diphospha...   457  e-128
GDA1_SCHPO (Q9UT35) Guanosine-diphosphatase (EC 3.6.1.42) (GDPase)    198  3e-50
ENP5_HUMAN (O75356) Ectonucleoside triphosphate diphosphohydrola...   179  2e-44
ENP5_MOUSE (Q9WUZ9) Ectonucleoside triphosphate diphosphohydrola...   174  4e-43
ENP5_MESAU (Q9QYC8) Ectonucleoside triphosphate diphosphohydrola...   169  1e-41
ENP6_HUMAN (O75354) Ectonucleoside triphosphate diphosphohydrola...   167  7e-41
GDA1_CANAL (Q8TGH6) Guanosine-diphosphatase (EC 3.6.1.42) (GDPase)    165  2e-40
GDA1_ASPFU (Q8TGG8) Probable guanosine-diphosphatase (EC 3.6.1.4...   165  2e-40
ENP6_RAT (Q9ER31) Ectonucleoside triphosphate diphosphohydrolase...   164  3e-40
GDA1_KLULA (Q9HEM6) Guanosine-diphosphatase (EC 3.6.1.42) (GDPase)    159  2e-38
GDA1_YEAST (P32621) Guanosine-diphosphatase (EC 3.6.1.42) (GDPase)    155  3e-37
ENP1_HUMAN (P49961) Ectonucleoside triphosphate diphosphohydrola...   145  3e-34
ENP1_RAT (P97687) Ectonucleoside triphosphate diphosphohydrolase...   140  7e-33
ENP2_CHICK (P79784) Ectonucleoside triphosphate diphosphohydrola...   139  2e-32
ENP1_MOUSE (P55772) Ectonucleoside triphosphate diphosphohydrola...   138  3e-32
MI23_CAEEL (Q21815) Nucleoside-diphosphatase mig-23 (EC 3.6.1.-)...   137  7e-32
NTP1_CAEEL (Q18411) Putative nucleoside-triphosphatase ntp-1 (EC...   129  1e-29
ENP2_RAT (O35795) Ectonucleoside triphosphate diphosphohydrolase...   129  1e-29
ENP2_HUMAN (Q9Y5L3) Ectonucleoside triphosphate diphosphohydrola...   128  3e-29

>NTPA_PEA (P52914) Nucleoside-triphosphatase (EC 3.6.1.15)
           (Nucleoside triphosphate phosphohydrolase) (NTPase)
           (Apyrase)
          Length = 455

 Score =  648 bits (1672), Expect = 0.0
 Identities = 314/457 (68%), Positives = 378/457 (82%), Gaps = 3/457 (0%)

Query: 1   MDFLISLMTFVFMLMPAISSSQYLGNNILMNRKILLPKNQEPVTSYAVIFDAGSTGSRVH 60
           M+ LI L+TF+   MPAI+SSQYLGNN+L +RKI L   QE ++SYAV+FDAGSTGSR+H
Sbjct: 1   MELLIKLITFLLFSMPAITSSQYLGNNLLTSRKIFL--KQEEISSYAVVFDAGSTGSRIH 58

Query: 61  VYNFDQNLDLLPVENELEFYDSVKPGLSSYAANPEEAAESLIPLLKEAENVVPVSQQPNT 120
           VY+F+QNLDLL +   +E+Y+ + PGLSSYA NPE+AA+SLIPLL++AE+VVP   QP T
Sbjct: 59  VYHFNQNLDLLHIGKGVEYYNKITPGLSSYANNPEQAAKSLIPLLEQAEDVVPDDLQPKT 118

Query: 121 PVKLGATAGLRLLEGNAAENILQAVRDMLSNRSALNVQSDAVSILDGTQEGSYLWVTINY 180
           PV+LGATAGLRLL G+A+E ILQ+VRDMLSNRS  NVQ DAVSI+DGTQEGSYLWVT+NY
Sbjct: 119 PVRLGATAGLRLLNGDASEKILQSVRDMLSNRSTFNVQPDAVSIIDGTQEGSYLWVTVNY 178

Query: 181 LLGKLGKRFTKTVGVVDLGGGSVQMTYAVSRNTAKNAPKVPEGEDPYIKKLVLQGKKYDL 240
            LG LGK++TKTVGV+DLGGGSVQM YAVS+ TAKNAPKV +G+DPYIKK+VL+G  YDL
Sbjct: 179 ALGNLGKKYTKTVGVIDLGGGSVQMAYAVSKKTAKNAPKVADGDDPYIKKVVLKGIPYDL 238

Query: 241 YVHSYLRYGREAFRAEIFKVAGGSANPCILAGFDGAYTYSGAEYKVSAPASGSNLNQCRK 300
           YVHSYL +GREA RAEI K+   S NPC+LAGF+G YTYSG E+K +A  SG+N N+C+ 
Sbjct: 239 YVHSYLHFGREASRAEILKLTPRSPNPCLLAGFNGIYTYSGEEFKATAYTSGANFNKCKN 298

Query: 301 IALKALKVNAPCPYQNCTFGGIWNGGGGSGQKNLFLTSSFYYLSEDVG-IFVNKPNAKIR 359
              KALK+N PCPYQNCTFGGIWNGGGG+GQKNLF +SSF+YL ED G +  + PN  +R
Sbjct: 299 TIRKALKLNYPCPYQNCTFGGIWNGGGGNGQKNLFASSSFFYLPEDTGMVDASTPNFILR 358

Query: 360 PVDLKTAAKLACKTNLEDAKSKYPDLYEKDSVEYVCLDLVYVYTLLVDGFGLDPFQEVTV 419
           PVD++T AK AC  N EDAKS YP L +K+   YVC+DL+Y Y LLVDGFGLDP Q++T 
Sbjct: 359 PVDIETKAKEACALNFEDAKSTYPFLDKKNVASYVCMDLIYQYVLLVDGFGLDPLQKITS 418

Query: 420 ANEIEYQDALVEAAWPLGTAIEAISSLPKFERLMYFI 456
             EIEYQDA+VEAAWPLG A+EAIS+LPKFERLMYF+
Sbjct: 419 GKEIEYQDAIVEAAWPLGNAVEAISALPKFERLMYFV 455


>APY_SOLTU (P80595) Apyrase precursor (EC 3.6.1.5)
           (ATP-diphosphatase) (Adenosine diphosphatase) (ADPase)
           (ATP-diphosphohydrolase)
          Length = 454

 Score =  457 bits (1175), Expect = e-128
 Identities = 226/442 (51%), Positives = 311/442 (70%), Gaps = 7/442 (1%)

Query: 5   ISLMTFVFMLMPAISSSQYLGNNILMNRKILLPKNQEPVTSYAVIFDAGSTGSRVHVYNF 64
           I ++  +F+++P    S+ +   I + R +L  +++     YAVIFDAGSTGSRVHV+ F
Sbjct: 9   IFIILAIFLVLPLSLLSKNVNAQIPLRRHLLSHESEH----YAVIFDAGSTGSRVHVFRF 64

Query: 65  DQNLDLLPVENELEFYDSVKPGLSSYAANPEEAAESLIPLLKEAENVVPVSQQPNTPVKL 124
           D+ L LLP+ N +E++ + +PGLSSYA +P+ AA SL PLL  AE VVP   Q  TP++L
Sbjct: 65  DEKLGLLPIGNNIEYFMATEPGLSSYAEDPKAAANSLEPLLDGAEGVVPQELQSETPLEL 124

Query: 125 GATAGLRLLEGNAAENILQAVRDMLSNRSALNVQSDAVSILDGTQEGSYLWVTINYLLGK 184
           GATAGLR+L+G+AAE ILQAVR+++ N+S  + +   V+ILDGTQEGSY+W  INYLLG 
Sbjct: 125 GATAGLRMLKGDAAEKILQAVRNLVKNQSTFHSKDQWVTILDGTQEGSYMWAAINYLLGN 184

Query: 185 LGKRFTKTVGVVDLGGGSVQMTYAVSRNTAKNAPKVPEGEDPYIKKLVLQGKKYDLYVHS 244
           LGK +  T   +DLGGGSVQM YA+S      AP+  +GE PY+++  L  K Y+LYVHS
Sbjct: 185 LGKDYKSTTATIDLGGGSVQMAYAISNEQFAKAPQNEDGE-PYVQQKHLMSKDYNLYVHS 243

Query: 245 YLRYGREAFRAEIFKVAGGSANPCILAGFDGAYTYSGAEYKVSAPASGSNLNQCRKIALK 304
           YL YG+ A RAEIFK +   +NPC L G DG Y+Y G +YKV AP  GS+  +CR++   
Sbjct: 244 YLNYGQLAGRAEIFKASRNESNPCALEGCDGYYSYGGVDYKVKAPKKGSSWKRCRRLTRH 303

Query: 305 ALKVNAPCPYQNCTFGGIWNGGGGSGQKNLFLTSSFYYLSEDVGIFVNK-PNAKIRPVDL 363
           ALK+NA C  + CTF G+WNGGGG GQKN+  +S FY +   VGI   K P+A  +P+  
Sbjct: 304 ALKINAKCNIEECTFNGVWNGGGGDGQKNIHASSFFYDIGAQVGIVDTKFPSALAKPIQY 363

Query: 364 KTAAKLACKTNLEDAKSKYPDLYEKDSVEYVCLDLVYVYTLLVDGFGLDPFQEVTVANEI 423
             AAK+AC+TN+ D KS +P   ++ ++ Y+C+DL+Y YTLLVDGFGL+P +E+TV +++
Sbjct: 364 LNAAKVACQTNVADIKSIFPKTQDR-NIPYLCMDLIYEYTLLVDGFGLNPHKEITVIHDV 422

Query: 424 EYQDALVEAAWPLGTAIEAISS 445
           +Y++ LV AAWPLG AI+ +SS
Sbjct: 423 QYKNYLVGAAWPLGCAIDLVSS 444


>GDA1_SCHPO (Q9UT35) Guanosine-diphosphatase (EC 3.6.1.42) (GDPase)
          Length = 556

 Score =  198 bits (503), Expect = 3e-50
 Identities = 151/433 (34%), Positives = 220/433 (49%), Gaps = 44/433 (10%)

Query: 39  NQEPVTSYAVIFDAGSTGSRVHVYNFDQNLDLLPVENELEFYDSVKPGLSSYAANPEEAA 98
           N +PV  Y ++ DAGSTGSRVHVY F+ N +  P   E EF+  ++PGLSS+A +PE AA
Sbjct: 127 NSKPVRQYVLMIDAGSTGSRVHVYQFN-NCNPSPKLEE-EFFKMIEPGLSSFAGDPEGAA 184

Query: 99  ESLIPLLKEAENVVPVSQQPNTPVKLGATAGLRLLEGNAAENILQAVRDMLSNRSALNVQ 158
            SL PLL  A   VP   +  +P+ + ATAGLRL   + A+ IL++VR  L N     + 
Sbjct: 185 ASLDPLLDYAMENVPEEYRRCSPIAVKATAGLRLTGESEAKAILKSVRQHLENDYPFPIV 244

Query: 159 SDAVSILDGTQEGSYLWVTINYLLGKLGKRFT-KTVGVVDLGGGSVQMTYAVSRNTAKNA 217
            D VSIL+G+ EG Y W+TINYLLG LG + T  TV V+DLGG S Q+ +      A + 
Sbjct: 245 KDGVSILEGSMEGIYAWITINYLLGTLGGKATHSTVAVMDLGGASTQLVF--EPRFASDG 302

Query: 218 PKVPEGEDPYIKKLVLQGKKYDLYVHSYLRYGREAFRAEIFKVAGGSA------------ 265
             + +G+  Y+  L   G++Y+LY HS+L YG +  R  I K    +A            
Sbjct: 303 ESLVDGDHKYV--LDYNGEQYELYQHSHLGYGLKEARKLIHKFVLNNAEALKESLELLGD 360

Query: 266 -----NPCILAGFDGAYTYSGAEYKVS-----APASGSNLNQCRKIALKALKVNAPCPYQ 315
                +PC+    + + T+  ++ + S      P+      QCR IA KAL  +  CP +
Sbjct: 361 STSIIHPCL--HLNASLTHPDSKSEASEVVFVGPSLAHLSLQCRGIAEKALYKDKNCPVR 418

Query: 316 NCTFGGIWNGGGGS--GQKNLFLTSSFYYLSEDVGIFVNKPNAKIRPVDLKTAAKLACK- 372
            C+F G+             ++L S FY    D  I +  P+      D+K  A   C  
Sbjct: 419 PCSFNGVHQPKFTETFTDSPIYLISYFY----DRMISLGMPST-FTIEDMKYLANSVCSG 473

Query: 373 -TNLEDAKSKYPDLYEKDSVEYVCLDLVYVYTLLVDGFGLDPFQEVTVANEIEYQDALVE 431
            T  +DA S    L E       CLDL Y+ +LL  G+ +   +++  A +I+ +    E
Sbjct: 474 PTYWQDAFSLTDALKELKEEPEWCLDLNYMISLLSVGYEIPNNRQLHTAKKIDNK----E 529

Query: 432 AAWPLGTAIEAIS 444
             W LG ++  +S
Sbjct: 530 LGWCLGASLSMLS 542


>ENP5_HUMAN (O75356) Ectonucleoside triphosphate diphosphohydrolase
           5 precursor (EC 3.6.1.6) (NTPDase5) (Nucleoside
           diphosphatase) (CD39 antigen-like 4) (ER-UDPase)
          Length = 428

 Score =  179 bits (453), Expect = 2e-44
 Identities = 132/422 (31%), Positives = 203/422 (47%), Gaps = 45/422 (10%)

Query: 35  LLPKNQEPVTSYAVIFDAGSTGSRVHVYNFDQNLD-LLPVENELEFYDSVKPGLSSYAAN 93
           + P N    T Y ++FDAGSTG+R+HVY F Q +   LP+  E E +DSVKPGLS++   
Sbjct: 38  MCPINVSASTLYGIMFDAGSTGTRIHVYTFVQKMPGQLPIL-EGEVFDSVKPGLSAFVDQ 96

Query: 94  PEEAAESLIPLLKEAENVVPVSQQPNTPVKLGATAGLRLLEGNAAENILQAVRDMLSNRS 153
           P++ AE++  LL+ A++ +P S    TPV L ATAGLRLL  + A+ +L  V+++   +S
Sbjct: 97  PKQGAETVQGLLEVAKDSIPRSHWKKTPVVLKATAGLRLLPEHKAKALLFEVKEIF-RKS 155

Query: 154 ALNVQSDAVSILDGTQEGSYLWVTINYLLGKLGKRFTKTVGVVDLGGGSVQMTYAVSRNT 213
              V   +VSI+DG+ EG   WVT+N+L G+L     +TVG +DLGG S Q+T+      
Sbjct: 156 PFLVPKGSVSIMDGSDEGILAWVTVNFLTGQLHGHRQETVGTLDLGGASTQITFL--PQF 213

Query: 214 AKNAPKVPEGEDPYIKKLVLQGKKYDLYVHSYLRYGREAFRAEIFKVAGGSA-------N 266
            K   + P G   Y+    +    Y LY HSYL +G +A R                  +
Sbjct: 214 EKTLEQTPRG---YLTSFEMFNSTYKLYTHSYLGFGLKAARLATLGALETEGTDGHTFRS 270

Query: 267 PCILAGFDGAYTYSGAEYKVSAPASGS-NLNQCRKIALKALKVNAPCPYQNCTFGGIWNG 325
            C+    +  + + G +Y+      G      C    L+ ++     P +          
Sbjct: 271 ACLPRWLEAEWIFGGVKYQYGGNQEGEVGFEPCYAEVLRVVRGKLHQPEE---------- 320

Query: 326 GGGSGQKNLFLTSSFYY-LSEDVGIFVNKPNAKIRPVDLKTAAKLACKTNLEDAKSKYPD 384
                Q+  F   S+YY  + D  +   +    ++  D +  A+  C  NLE+  S  P 
Sbjct: 321 ----VQRGSFYAFSYYYDRAVDTDMIDYEKGGILKVEDFERKAREVC-DNLENFTSGSP- 374

Query: 385 LYEKDSVEYVCLDLVYVYTLLVDGFGLDPFQEVTVANEIEYQDALVEAAWPLGTAIEAIS 444
                   ++C+DL Y+  LL DGFG   F + TV  ++  +   +E  W LG     + 
Sbjct: 375 --------FLCMDLSYITALLKDGFG---FADSTVL-QLTKKVNNIETGWALGATFHLLQ 422

Query: 445 SL 446
           SL
Sbjct: 423 SL 424


>ENP5_MOUSE (Q9WUZ9) Ectonucleoside triphosphate diphosphohydrolase
           5 precursor (EC 3.6.1.6) (NTPDase5) (Nucleoside
           diphosphatase) (CD39 antigen-like 4) (ER-UDPase)
          Length = 427

 Score =  174 bits (441), Expect = 4e-43
 Identities = 128/422 (30%), Positives = 196/422 (46%), Gaps = 45/422 (10%)

Query: 35  LLPKNQEPVTSYAVIFDAGSTGSRVHVYNFDQNLDLLPVENELEFYDSVKPGLSSYAANP 94
           + P N    T Y ++FDAGSTG+R+HVY F Q         E E +DSVKPGLS++   P
Sbjct: 37  MCPINVSAGTFYGIMFDAGSTGTRIHVYTFVQKTAGQLPFLEGEIFDSVKPGLSAFVDQP 96

Query: 95  EEAAESLIPLLKEAENVVPVSQQPNTPVKLGATAGLRLLEGNAAENILQAVRDMLSNRSA 154
           ++ AE++  LL+ A++ +P S    TPV L ATAGLRLL    A+ +L  V ++  N S 
Sbjct: 97  KQGAETVQELLEVAKDSIPRSHWERTPVVLKATAGLRLLPEQKAQALLLEVEEIFKN-SP 155

Query: 155 LNVQSDAVSILDGTQEGSYLWVTINYLLGKLGKRFTKTVGVVDLGGGSVQMTYAVSRNTA 214
             V   +VSI+DG+ EG   WVT+N+L G+L  R  +TVG +DLGG S Q+T+       
Sbjct: 156 FLVPDGSVSIMDGSYEGILAWVTVNFLTGQLHGRGQETVGTLDLGGASTQITFL--PQFE 213

Query: 215 KNAPKVPEGEDPYIKKLVLQGKKYDLYVHSYLRYGREAFRAEIFKV--AGGS-----ANP 267
           K   + P G   Y+    +    + LY HSYL +G +A R        A G+      + 
Sbjct: 214 KTLEQTPRG---YLTSFEMFNSTFKLYTHSYLGFGLKAARLATLGALEAKGTDGHTFRSA 270

Query: 268 CILAGFDGAYTYSGAEYKVSAPASGS-NLNQCRKIALKAL--KVNAPCPYQNCTFGGIWN 324
           C+    +  + + G +Y+      G      C    L+ +  K++ P   +   F     
Sbjct: 271 CLPRWLEAEWIFGGVKYQYGGNQEGEMGFEPCYAEVLRVVQGKLHQPEEVRGSAF----- 325

Query: 325 GGGGSGQKNLFLTSSFYYLSEDVGIFVNKPNAKIRPVDLKTAAKLACKTNLEDAKSKYPD 384
                     +  S +Y  + D  +   +    ++  D +  A+  C  NL    S  P 
Sbjct: 326 ----------YAFSYYYDRAADTHLIDYEKGGVLKVEDFERKAREVC-DNLGSFSSGSP- 373

Query: 385 LYEKDSVEYVCLDLVYVYTLLVDGFGLDPFQEVTVANEIEYQDALVEAAWPLGTAIEAIS 444
                   ++C+DL Y+  LL DGFG      + +  ++      +E  W LG     + 
Sbjct: 374 --------FLCMDLTYITALLKDGFGFADGTLLQLTKKVNN----IETGWALGATFHLLQ 421

Query: 445 SL 446
           SL
Sbjct: 422 SL 423


>ENP5_MESAU (Q9QYC8) Ectonucleoside triphosphate diphosphohydrolase
           5 precursor (EC 3.6.1.6) (NTPDase5) (Nucleoside
           diphosphatase) (CD39 antigen-like 4) (ER-UDPase)
           (Proto-oncogene cph)
          Length = 469

 Score =  169 bits (428), Expect = 1e-41
 Identities = 122/414 (29%), Positives = 192/414 (45%), Gaps = 47/414 (11%)

Query: 35  LLPKNQEPVTSYAVIFDAGSTGSRVHVYNFDQNLDLLPVENELEFYDSVKPGLSSYAANP 94
           + P N    T Y ++FDAGSTG+R+HVY F Q         E E +DSVKPGLS++A  P
Sbjct: 38  MCPANVSASTFYGIMFDAGSTGTRIHVYTFVQKAAGQLPFLEGEIFDSVKPGLSAFADQP 97

Query: 95  EEAAESLIPLLKEAENVVPVSQQPNTPVKLGATAGLRLLEGNAAENILQAVRDMLSNRSA 154
           ++ A+++  LL+ A++ +P S    TPV L ATAGLRLL    A+ +L  V ++    S 
Sbjct: 98  KQGAQTVHALLEVAKDSIPRSHWKRTPVVLKATAGLRLLPEQKAQALLLEVEEIF-KMSP 156

Query: 155 LNVQSDAVSILDGTQEGSYLWVTINYLLGKLGKRFTKTVGVVDLGGGSVQMTYAVS-RNT 213
             V  D+VSI+DG+ EG   WVT+N+L G+L     +T+G +DLGG S Q+T+      T
Sbjct: 157 FLVPDDSVSIMDGSYEGILAWVTVNFLTGQLHGHSQETMGTLDLGGASTQITFLPQFSKT 216

Query: 214 AKNAPKVPEGEDPYIKKLVLQGKKYDLYVHSYLRYGREAFRAEIFKVAGGSA-------N 266
            +  P+       Y+    +    + LY HSYL +G +A R                  +
Sbjct: 217 LEQTPR------DYLTSFEMFNSTFKLYTHSYLGFGLKAARLATLGALETEGTDGHTFRS 270

Query: 267 PCILAGFDGAYTYSGAEYKVSAPASGS-NLNQCRKIALKAL--KVNAPCPYQNCTFGGIW 323
            C+    +  + + G +Y+      G      C    L+ +  K++ P   +  +F    
Sbjct: 271 ACLPRWLEAEWIFGGVKYQYGGNQEGEMGFEPCYAEVLRVVQGKLHQPEEIRGSSF---- 326

Query: 324 NGGGGSGQKNLFLTSSFYYLSEDVGIFVNKPNAKIRPVDLKTAAKLACKTNLEDAKSKYP 383
                      +  S +Y  + D  +   +    ++  D +  A+  C  NLE   S  P
Sbjct: 327 -----------YAFSYYYDRAADTHLIDYEKGGVLKVEDFERKAREVC-DNLESFTSGSP 374

Query: 384 DLYEKDSVEYVCLDLVYVYTLLVDGFGLDPFQEVTVANEIEYQDALVEAAWPLG 437
                    ++C+DL Y+  LL DGFG      + +  ++      +E  WP G
Sbjct: 375 ---------FLCMDLSYITALLKDGFGFADGTLLQLTKKVNN----IETGWPGG 415


>ENP6_HUMAN (O75354) Ectonucleoside triphosphate diphosphohydrolase
           6 (EC 3.6.1.6) (NTPDase6) (CD39 antigen-like 2)
          Length = 484

 Score =  167 bits (422), Expect = 7e-41
 Identities = 126/409 (30%), Positives = 195/409 (46%), Gaps = 42/409 (10%)

Query: 46  YAVIFDAGSTGSRVHVYNFDQNLDLLPVENELEFYDSVKPGLSSYAANPEEAAESLIPLL 105
           Y ++FDAGSTG+RVHV+ F +     P     E + ++KPGLS+YA + E++A+ +  LL
Sbjct: 102 YGIMFDAGSTGTRVHVFQFTRPPRETPTLTH-ETFKALKPGLSAYADDVEKSAQGIRELL 160

Query: 106 KEAENVVPVSQQPNTPVKLGATAGLRLLEGNAAENILQAVRDMLSNRSALNVQSDAVSIL 165
             A+  +P      TP+ L ATAGLRLL G  A+ +LQ V+++    S   V  D VSI+
Sbjct: 161 DVAKQDIPFDFWKATPLVLKATAGLRLLPGEKAQKLLQKVKEVFK-ASPFLVGDDCVSIM 219

Query: 166 DGTQEGSYLWVTINYLLGKLGKRFTKTVGVVDLGGGSVQMTYAVSRNTAKNAPKVPEGED 225
           +GT EG   W+TIN+L G L      +VG++DLGGGS Q+ +         A   P G  
Sbjct: 220 NGTDEGVSAWITINFLTGSLKTPGGSSVGMLDLGGGSTQIAFLPRVEGTLQAS--PPG-- 275

Query: 226 PYIKKLVLQGKKYDLYVHSYLRYGREAFRAEIFKVAGGS--------ANPCILAGFDGAY 277
            Y+  L +  + Y LY +SYL  G  + R  I     G          +PC+   F G +
Sbjct: 276 -YLTALRMFNRTYKLYSYSYLGLGLMSARLAILGGVEGQPAKDGKELVSPCLSPSFKGEW 334

Query: 278 TYSGAEYKVSAPASGSNLNQCRKIALKALKVNAPCPYQNCTFGGIWNGGGGSGQKNLFLT 337
            ++   Y+VS   + ++L++     +  +  N     +                 + +  
Sbjct: 335 EHAEVTYRVSGQKAAASLHELCAARVSEVLQNRVHRTEEVK------------HVDFYAF 382

Query: 338 SSFYYLSEDVGIFVNKPNAKIRPVDLKTAAKLACKTNLEDAKSKYPDLYEKDSVEYVCLD 397
           S +Y L+  VG+   +    +   D + AAK  C+T LE      P         + C+D
Sbjct: 383 SYYYDLAAGVGLIDAEKGGSLVVGDFEIAAKYVCRT-LETQPQSSP---------FSCMD 432

Query: 398 LVYVYTLLVDGFGLDPFQEVTVANEIEYQDALVEAAWPLGTAIEAISSL 446
           L YV +LL+  FG    + + +  +I+     VE +W LG     I SL
Sbjct: 433 LTYV-SLLLQEFGFPRSKVLKLTRKIDN----VETSWALGAIFHYIDSL 476


>GDA1_CANAL (Q8TGH6) Guanosine-diphosphatase (EC 3.6.1.42) (GDPase)
          Length = 599

 Score =  165 bits (418), Expect = 2e-40
 Identities = 145/444 (32%), Positives = 206/444 (45%), Gaps = 74/444 (16%)

Query: 46  YAVIFDAGSTGSRVHVYNFDQNLDLLPVENELEFYDSVKPGLSSYAANPEEAAESLIPLL 105
           Y V+ DAGSTGSRVHVY F  N  + P +   E ++ +KPGLSS+  +   AA+SL PLL
Sbjct: 163 YVVMIDAGSTGSRVHVYEF--NTCVKPPQLLSEEFEMLKPGLSSFDTDTVGAAKSLDPLL 220

Query: 106 KEAENVVPVSQQPNTPVKLGATAGLRLLEGNAAENILQAVRDMLSNRSALNVQS-DAVSI 164
           + A   VP ++Q  TPV + ATAGLRLL    ++ IL  VR  L       V S D +SI
Sbjct: 221 EVALKKVPKNKQSCTPVAVKATAGLRLLGETKSKAILDEVRSHLEKDYPFAVVSEDGISI 280

Query: 165 LDGTQEGSYLWVTINYLLGKL-GKRFTKTVGVVDLGGGSVQMTYAVSRNTAKNAPKVP-E 222
           +DG  EG Y WVT NYLLG + GK    T  V DLGGGS Q+ +           +VP +
Sbjct: 281 MDGKDEGVYAWVTANYLLGNIGGKEKLPTAAVFDLGGGSTQIVF----EPDYKVDEVPVD 336

Query: 223 GEDPYIKKLVLQGKKYDLYVHSYLRYGREAFRAEI-------------------FKVAGG 263
           GE  Y         +Y LY  S+L YG    R ++                    +V G 
Sbjct: 337 GETKY--HFTFGDNQYTLYQFSHLGYGLMQGRNKVNQLVLKNKLSELNLQKYTKKEVKGA 394

Query: 264 SA-----NPCILAGF-----------DGAYTYS--GAEYKVSAPASGSNLNQCRKIALKA 305
            A     NPCI  G            D  Y  +  G   K S  A GS   QCR +A K 
Sbjct: 395 KATVDVSNPCIPPGVVAKDVQVELGEDEFYVVNMKGPSSKDSTVAGGS---QCRYLAEKV 451

Query: 306 LKVNAPCPYQNCTFGGIWNGG---GGSGQKNLFLTSSFYYLSEDVGIFVNKPNAKIRPVD 362
           L  +A C  + C+F G+         +   ++++ S FY  +  +G+      +     +
Sbjct: 452 LNKDAECTSKPCSFNGVHQPSLTRTFNKNSDMYVFSYFYDRTNPIGM-----PSSFSVEE 506

Query: 363 LKTAAKLACKTNLEDAKSKYPDLYEKDSVEYV------CLDLVYVYTLLVDGFGLDPFQE 416
           LK  +KL C+      ++ + D+   D V+ +      CLDL ++  +L  G+ +   +E
Sbjct: 507 LKDLSKLVCQ-----GETFWKDILLDDHVKNLNEEPQWCLDLSFITAMLHTGYDIPLHRE 561

Query: 417 VTVANEIEYQDALVEAAWPLGTAI 440
           +  A  I+      E  W LG ++
Sbjct: 562 LKTAKTIDNN----ELGWCLGASL 581


>GDA1_ASPFU (Q8TGG8) Probable guanosine-diphosphatase (EC 3.6.1.42)
           (GDPase)
          Length = 558

 Score =  165 bits (418), Expect = 2e-40
 Identities = 135/445 (30%), Positives = 212/445 (47%), Gaps = 52/445 (11%)

Query: 40  QEPVTSYAVIFDAGSTGSRVHVYNFDQNLDLLPVENELEFYDSVKPG---LSSYAANPEE 96
           ++P+  YA++ DAGS GSR+HVY F+       +E+E+ F    K G   LSSY  + E 
Sbjct: 113 KKPLIQYALMIDAGSQGSRIHVYRFNNCGPSPELEDEVFFQTEPKKGGSGLSSYKEDAEG 172

Query: 97  AAESLIPLLKEAENVVPVSQQPNTPVKLGATAGLRLLEGNAAENILQAVRDMLSN---RS 153
           AA+SL PL++ A   VP   +  +P+ + ATAGLR+L    ++ IL AVR+ L       
Sbjct: 173 AAKSLDPLMEVAMKNVPDEYKSCSPIAVKATAGLRMLGPELSQKILDAVRNRLETVYPFP 232

Query: 154 ALNVQSDAVSILDGTQEGSYLWVTINYLLGKL-GKRFTKTVGVVDLGGGSVQMTYAVSRN 212
            ++ +   V I+DG+ EG Y W+T NYLLGK+ G   T T  V DLGGGS Q+ +  +  
Sbjct: 233 VVSKEKGGVEIMDGSDEGVYAWITTNYLLGKIGGPDETPTAAVFDLGGGSTQIVFQPTFP 292

Query: 213 TAKNA---PKVPEGEDPYIKKLVLQGKKYDLYVHSYLRYG----REAFRAEIFKVAGGSA 265
            +K+     ++ EG+  Y   L   G+ ++LY HS+L YG    R+A    I +    S+
Sbjct: 293 KSKSGGMPERLSEGDHKY--DLQFGGRHFELYQHSHLGYGLMAARKAIHTSIIENMLASS 350

Query: 266 ------------NPCI---------LAGFDGAYTYSGAEYKVSAPASGSNLNQCRKIALK 304
                       NPCI         L   +G       +  +  P  GS   QCR +A K
Sbjct: 351 PKDLSWLKQPIPNPCIGPEMEKNVTLEFPEGHKLAPEVQVTMVGPKVGSTAAQCRGLAEK 410

Query: 305 ALKVNAPCPYQNCTFGGIWNGG--GGSGQKNLFLTSSFYYLSEDVGI---FVNKPNAKIR 359
            L   A C    C+F G+          ++++++ S FY  ++ +G+   F      ++ 
Sbjct: 411 TLNKEAACTLAPCSFNGVHQPSLEKTFAREDVYIFSYFYDRTKPLGMPDSFTLDELHQLT 470

Query: 360 PVDLKTAAKLACKTNLEDAKSKYPDLYEKDSVEYVCLDLVYVYTLLVDGFGLDPFQEVTV 419
                          +E A  +  D  E       CLDL ++ +LL  G+ +   +EV +
Sbjct: 471 STVCGGEDSWGIFAGIEGALKELRDRPE------WCLDLNFMMSLLHTGYEMPLSREVKI 524

Query: 420 ANEIEYQDALVEAAWPLGTAIEAIS 444
           A +I+ +    E  W LG ++  +S
Sbjct: 525 AKKIKNR----ELGWCLGASLPLLS 545


>ENP6_RAT (Q9ER31) Ectonucleoside triphosphate diphosphohydrolase 6
           (EC 3.6.1.6) (NTPDase6) (CD39 antigen-like 2)
          Length = 455

 Score =  164 bits (416), Expect = 3e-40
 Identities = 125/413 (30%), Positives = 197/413 (47%), Gaps = 47/413 (11%)

Query: 46  YAVIFDAGSTGSRVHVYNFDQNLDLLPVENELEFYDSVKPGLSSYAANPEEAAESLIPLL 105
           Y ++FDAGSTG+R+HV+ F +     P     E + ++KPGLS+YA + E++A+ +  LL
Sbjct: 74  YGIMFDAGSTGTRIHVFQFARPPGETPTLTH-ETFKALKPGLSAYADDVEKSAQGIQELL 132

Query: 106 KEAENVVPVSQQPNTPVKLGATAGLRLLEGNAAENILQAVRDMLSNRSALNVQSDAVSIL 165
             A+  +P      TP+ L ATAGLRLL G  A+ +LQ V+++    S   V  D VSI+
Sbjct: 133 NVAKQHIPYDFWKATPLVLKATAGLRLLPGEKAQKLLQKVKEVF-KASPFLVGDDCVSIM 191

Query: 166 DGTQEGSYLWVTINYLLGKLGKRFTKTVGVVDLGGGSVQMTYAVSRNTAKNAPKVPEGED 225
           +GT EG   W+T+N+L G L    + +VG++DLGGGS Q+T+         A   P G  
Sbjct: 192 NGTDEGVSAWITVNFLTGSLKTPGSSSVGMLDLGGGSTQITFLPRVEGTLQAS--PPG-- 247

Query: 226 PYIKKLVLQGKKYDLYVHSYLRYGREAFRAEIFKVAGGS--------ANPCILAGFDGAY 277
            ++  L +  + + LY +SYL  G  + R  I     G          +PC+   F G +
Sbjct: 248 -HLTALQMFNRTFKLYSYSYLGLGLMSARLAILGGVEGKPAEDDKELVSPCLSPRFRGKW 306

Query: 278 TYSGAEYKVSAPASGSNLNQCRKIALKAL--KVNAPCPYQNCTFGGIWNGGGGSGQKNLF 335
            ++   Y++S   +      C     + L  KV+     Q+  F               +
Sbjct: 307 EHAEVTYRISGQKAVGLYELCASRVSEVLRNKVHRTEEAQHVDF---------------Y 351

Query: 336 LTSSFYYLSEDVGIFVNKPNAKIRPVDLKTAAKLACKTNLEDAKSKYPDLYEKDSVEYVC 395
             S +Y L+   G+   +    +   D + AAK  C+T LE      P         + C
Sbjct: 352 AFSYYYDLAASFGLIDAEKGGSLVVGDFEIAAKYVCRT-LETQPPSSP---------FAC 401

Query: 396 LDLVYVYTLLVDGFGLDPFQEVTVANEIEYQDALVEAAWPLGTAIEAISSLPK 448
           +DL Y+ +LL+  FG    + + +A +I+     VE +W LG     I SL +
Sbjct: 402 MDLTYI-SLLLHEFGFPGDKVLKLARKIDN----VETSWALGAIFHYIDSLKR 449


>GDA1_KLULA (Q9HEM6) Guanosine-diphosphatase (EC 3.6.1.42) (GDPase)
          Length = 522

 Score =  159 bits (401), Expect = 2e-38
 Identities = 146/438 (33%), Positives = 201/438 (45%), Gaps = 61/438 (13%)

Query: 46  YAVIFDAGSTGSRVHVYNFDQNLDLLPVENELEFYDSVKPGLSSYAANPEEAAESLIPLL 105
           Y V+ DAGSTGSRVHVY FD       + NE   ++ +KPGLSS+  +   AA+SL PLL
Sbjct: 97  YVVMIDAGSTGSRVHVYEFDVCTQPPTLINET--FEMLKPGLSSFDIDAVGAAKSLDPLL 154

Query: 106 KEAENVVPVSQQPNTPVKLGATAGLRLLEGNAAENILQAVRDMLSNRSALN-VQSDAVSI 164
           K A + VP  ++  TPV + ATAGLR+L    +  IL  VR  L        V  D VSI
Sbjct: 155 KIAMDAVPKDKRNCTPVAVKATAGLRMLGDEKSSKILAQVRKHLEQDYPFPVVDGDGVSI 214

Query: 165 LDGTQEGSYLWVTINYLLGKLGK-RFTKTVGVVDLGGGSVQMTYAVSRNTAKNAPKVPEG 223
           +DG +EG Y WVT NYLLG +G      T  V DLGGGS Q+ +  S    +   K+ +G
Sbjct: 215 MDGEEEGVYAWVTANYLLGNIGAGSKLPTAAVFDLGGGSTQIVFEPSFPPNE---KMVDG 271

Query: 224 EDPYIKKLVLQGKKYDLYVHSYLRY----GREAFRAEIFKVAGGS--------------A 265
           E  Y  +L   G  Y LY  S+L Y    GR     E+  VA  S              +
Sbjct: 272 EHKY--ELSFGGHDYTLYQFSHLGYGLMQGRNKINTELVNVAISSGTITKGQTARTYELS 329

Query: 266 NPCILAGF-----------DGAYTYSGAEYKVSAPASGSNLNQCRKIALKALKVNAPCPY 314
           +PC+  G            D  YT +    KV A        QCR +A K L  +A C  
Sbjct: 330 SPCLPPGTTAEGEKVKISDDEIYTVNFKGPKVPAGP------QCRYLADKILNKDAKCNT 383

Query: 315 QNCTFGGIWNGG---GGSGQKNLFLTSSFYYLSEDVGIFVNKPNAKIRPVDLKTAAKLAC 371
             C+F GI             +L++ S FY  ++ +G+ ++         +L+  A+  C
Sbjct: 384 PPCSFNGIHQPSLVHTFKETSDLYVFSYFYDRTQPLGLPLS-----FTLQELQDLARTVC 438

Query: 372 KTNLEDAKSKYP----DLYEKDSVEYVCLDLVYVYTLLVDGFGLDPFQEVTVANEIEYQD 427
               E  +S +      L E       CLDL +  +LL  G+ +   +E+  A  I    
Sbjct: 439 NGE-EVWESVFSGIEGSLSELSKEPQWCLDLNFQVSLLHTGYDIPLQRELRTAKTI---- 493

Query: 428 ALVEAAWPLGTAIEAISS 445
           A  E  W LG ++  + S
Sbjct: 494 ANNELGWCLGASLPLLES 511


>GDA1_YEAST (P32621) Guanosine-diphosphatase (EC 3.6.1.42) (GDPase)
          Length = 518

 Score =  155 bits (391), Expect = 3e-37
 Identities = 135/434 (31%), Positives = 200/434 (45%), Gaps = 52/434 (11%)

Query: 46  YAVIFDAGSTGSRVHVYNFDQNLDLLPVENELEFYDSVKPGLSSYAANPEEAAESLIPLL 105
           Y ++ DAGSTGSRVH+Y FD  +   P     E +D ++PGLSS+  +   AA SL PLL
Sbjct: 93  YVIMIDAGSTGSRVHIYKFD--VCTSPPTLLDEKFDMLEPGLSSFDTDSVGAANSLDPLL 150

Query: 106 KEAENVVPVSQQPNTPVKLGATAGLRLLEGNAAENILQAVRDMLSNRSALN-VQSDAVSI 164
           K A N VP+  +  TPV + ATAGLRLL    +  IL AVRD L        V+ D VSI
Sbjct: 151 KVAMNYVPIKARSCTPVAVKATAGLRLLGDAKSSKILSAVRDHLEKDYPFPVVEGDGVSI 210

Query: 165 LDGTQEGSYLWVTINYLLGKLGKRFTK--TVGVVDLGGGSVQMTYAVSRNTAKNAPKVPE 222
           + G +EG + W+T NYLLG +G    K  T  V DLGGGS Q+ +     T     K+ +
Sbjct: 211 MGGDEEGVFAWITTNYLLGNIGANGPKLPTAAVFDLGGGSTQIVF---EPTFPINEKMVD 267

Query: 223 GEDPYIKKLVLQGKKYDLYVHSYLRYGREAFRAEIFKVAGGSA----------------- 265
           GE  +   L    + Y LY  S+L YG +  R ++  V   +A                 
Sbjct: 268 GEHKF--DLKFGDENYTLYQFSHLGYGLKEGRNKVNSVLVENALKDGKILKGDNTKTHQL 325

Query: 266 -NPCILAGFDGAYTYSGAEYKVS------APASGSNLNQCRKIALKALKVNAPCPYQNCT 318
            +PC+    +        E K +       P   S   QCR +  + L  +A C    C+
Sbjct: 326 SSPCLPPKVNATNEKVTLESKETYTIDFIGPDEPSGA-QCRFLTDEILNKDAQCQSPPCS 384

Query: 319 FGGIWNGG---GGSGQKNLFLTSSFYYLSEDVGIFVNKPNAKIRPVDLKTAAKLACKTNL 375
           F G+             ++++ S FY  +  +G+ ++         +L   A++ CK   
Sbjct: 385 FNGVHQPSLVRTFKESNDIYIFSYFYDRTRPLGMPLS-----FTLNELNDLARIVCKGE- 438

Query: 376 EDAKSKYP----DLYEKDSVEYVCLDLVYVYTLLVDGFGLDPFQEVTVANEIEYQDALVE 431
           E   S +      L E +S  + CLDL +  +LL  G+ +   +E+    +I    A  E
Sbjct: 439 ETWNSVFSGIAGSLDELESDSHFCLDLSFQVSLLHTGYDIPLQRELRTGKKI----ANKE 494

Query: 432 AAWPLGTAIEAISS 445
             W LG ++  + +
Sbjct: 495 IGWCLGASLPLLKA 508


>ENP1_HUMAN (P49961) Ectonucleoside triphosphate diphosphohydrolase
           1 (EC 3.6.1.5) (NTPDase1) (Ecto-ATP diphosphohydrolase)
           (ATPDase) (Lymphoid cell activation antigen)
           (Ecto-apyrase) (CD39 antigen)
          Length = 510

 Score =  145 bits (365), Expect = 3e-34
 Identities = 122/449 (27%), Positives = 197/449 (43%), Gaps = 65/449 (14%)

Query: 36  LPKNQEPVTSYAVIFDAGSTGSRVHVYNFDQNLDL-LPVENELEFYDSVKPGLSSYAANP 94
           LP+N      Y ++ DAGS+ + +++Y +    +    V +++E      PG+S +    
Sbjct: 43  LPEN----VKYGIVLDAGSSHTSLYIYKWPAEKENDTGVVHQVEECRVKGPGISKFVQKV 98

Query: 95  EEAAESLIPLLKEAENVVPVSQQPNTPVKLGATAGLRLLEGNA---AENILQAVRDMLSN 151
            E    L   ++ A  V+P SQ   TPV LGATAG+RLL   +   A+ +L  V   LSN
Sbjct: 99  NEIGIYLTDCMERAREVIPRSQHQETPVYLGATAGMRLLRMESEELADRVLDVVERSLSN 158

Query: 152 RSALNVQSDAVSILDGTQEGSYLWVTINYLLGKLGKRF------------TKTVGVVDLG 199
                       I+ G +EG+Y W+TINYLLGK  ++              +T G +DLG
Sbjct: 159 ---YPFDFQGARIITGQEEGAYGWITINYLLGKFSQKTRWFSIVPYETNNQETFGALDLG 215

Query: 200 GGSVQMTYAVSRNTAKNAPKVPEGEDPYIKKLVLQGKKYDLYVHSYLRYGREAF----RA 255
           G S Q+T+     T ++             +  L GK Y++Y HS+L YG++       A
Sbjct: 216 GASTQVTFVPQNQTIESPDNA--------LQFRLYGKDYNVYTHSFLCYGKDQALWQKLA 267

Query: 256 EIFKVAGGS--ANPCILAGFDGAYTYSG-------AEYKVSAPASG------SNLNQCRK 300
           +  +VA      +PC   G+      S          ++++ P          N  QC +
Sbjct: 268 KDIQVASNEILRDPCFHPGYKKVVNVSDLYKTPCTKRFEMTLPFQQFEIQGIGNYQQCHQ 327

Query: 301 IALKALKVNAPCPYQNCTFGGIWNGGGGSGQKNLFLTSSFYYLSEDVGIFVNKPNAKIRP 360
             L+    +  CPY  C F GI+       Q +    S+FY++ +    F+N  + K+  
Sbjct: 328 SILELFNTSY-CPYSQCAFNGIFL---PPLQGDFGAFSAFYFVMK----FLNLTSEKVSQ 379

Query: 361 VDLKTAAKLACKTNLEDAKSKYPDLYEKDSVEYVCLDLVYVYTLLVDG--FGLDPFQEVT 418
             +    K  C    E+ K+ Y  + EK   EY C    Y+ +LL+ G  F  D ++ + 
Sbjct: 380 EKVTEMMKKFCAQPWEEIKTSYAGVKEKYLSEY-CFSGTYILSLLLQGYHFTADSWEHIH 438

Query: 419 VANEIEYQDALVEAAWPLGTAIEAISSLP 447
              +I+  D    A W LG  +   + +P
Sbjct: 439 FIGKIQGSD----AGWTLGYMLNLTNMIP 463


>ENP1_RAT (P97687) Ectonucleoside triphosphate diphosphohydrolase 1
           (EC 3.6.1.5) (NTPDase1) (Ecto-ATP diphosphohydrolase)
           (ATPDase) (Lymphoid cell activation antigen)
           (Ecto-apyrase) (CD39 antigen)
          Length = 511

 Score =  140 bits (353), Expect = 7e-33
 Identities = 122/457 (26%), Positives = 196/457 (42%), Gaps = 80/457 (17%)

Query: 36  LPKNQEPVTSYAVIFDAGSTGSRVHVYNFDQNLDLLPVENE--------LEFYDSVKPGL 87
           LP+N      Y ++ DAGS+ + +++Y +       P E E        LE      PG+
Sbjct: 43  LPEN----VKYGIVLDAGSSHTNLYIYKW-------PAEKENDTGVVQLLEECQVKGPGI 91

Query: 88  SSYAANPEEAAESLIPLLKEAENVVPVSQQPNTPVKLGATAGLRLLEGNAAENILQAVRD 147
           S YA   +E A  L   +K +   +P S+Q  TPV LGATAG+RLL   + ++  + +  
Sbjct: 92  SKYAQKTDEIAAYLAECMKMSTERIPASKQHQTPVYLGATAGMRLLRMESKQSADEVLAA 151

Query: 148 MLSNRSALNVQSDAVSILDGTQEGSYLWVTINYLLGKLGKRFT-----------KTVGVV 196
           +  +  +         I+ G +EG+Y W+TINYLLG+  +  +            T G +
Sbjct: 152 VSRSLKSYPFDFQGAKIITGQEEGAYGWITINYLLGRFTQEQSWLNFISDSQKQATFGAL 211

Query: 197 DLGGGSVQMTYAVSRNTAKNAPKVPEGEDPYIKKLVLQGKKYDLYVHSYLRYGREAF--- 253
           DLGG S Q+T+ V  N    AP+          +  L G  Y +Y HS+L YG++     
Sbjct: 212 DLGGSSTQVTF-VPLNQTLEAPETS-------LQFRLYGTDYTVYTHSFLCYGKDQALWQ 263

Query: 254 -RAEIFKVAGGS--ANPCILAGFDGAYTYS-------GAEYKVSAP------ASGSNLNQ 297
             A+  +V+ G    +PC   G+      S          ++   P          +  Q
Sbjct: 264 KLAQDIQVSSGGILKDPCFYPGYKKVVNVSELYGTPCTKRFEKKLPFNQFQVQGTGDYEQ 323

Query: 298 CRKIALKALKVNAPCPYQNCTFGGIW----NGGGGSGQKNLFLTSSFYYLSEDVGIFVNK 353
           C +  LK    N+ CPY  C F G++     G  G+        S+FY++ +    F   
Sbjct: 324 CHQSILKFFN-NSHCPYSQCAFNGVFLPPLQGSFGA-------FSAFYFVMD---FFKKM 372

Query: 354 PNAKIRPVDLKT-AAKLACKTNLEDAKSKYPDLYEKDSVEYVCLDLVYVYTLLVDGFGLD 412
            N  +   +  T   K  C    E+ K+ YP + EK   EY C    Y+ +LL+ G+   
Sbjct: 373 ANDSVSSQEKMTEITKNFCSKPWEEVKASYPTVKEKYLSEY-CFSGTYILSLLLQGYNFT 431

Query: 413 PFQEVTVANEIEYQDALVE--AAWPLGTAIEAISSLP 447
                T  ++I +   + +  A W LG  +   + +P
Sbjct: 432 G----TSWDQIHFMGKIKDSNAGWTLGYMLNLTNMIP 464


>ENP2_CHICK (P79784) Ectonucleoside triphosphate diphosphohydrolase
           2 (EC 3.6.1.3) (NTPDase2) (Ecto-ATPase) (CD39
           antigen-like 1)
          Length = 494

 Score =  139 bits (350), Expect = 2e-32
 Identities = 123/442 (27%), Positives = 196/442 (43%), Gaps = 55/442 (12%)

Query: 42  PVTSYAVIFDAGSTGSRVHVYNF--DQNLDLLPVENELEFYDSVKPGLSSYAANPEEAAE 99
           P   Y ++ DAGS+ + V +Y +  D+  D   V +E    D   PG+SSY++ P  A +
Sbjct: 33  PSFKYGIVLDAGSSHTAVFIYKWPADKENDT-GVVSEHSMCDVEGPGISSYSSKPPAAGK 91

Query: 100 SLIPLLKEAENVVPVSQQPNTPVKLGATAGLRLL--EGNAAENILQAVRDMLSNRSALNV 157
           SL   L +A   VP  +  +TP+ LGATAG+RLL      ++  L AV   ++   +   
Sbjct: 92  SLEHCLSQAMRDVPKEKHADTPLYLGATAGMRLLTIADPPSQTCLSAV---MATLKSYPF 148

Query: 158 QSDAVSILDGTQEGSYLWVTINYLLGKLGKR---------FTKTVGVVDLGGGSVQMTYA 208
                 IL G +EG + W+T NYLL    KR           KT+G +D GG S Q+T+ 
Sbjct: 149 DFGGAKILSGEEEGVFGWITANYLLENFIKRGWLGEWIQSKKKTLGAMDFGGASTQITFE 208

Query: 209 VSRNTAKNAPKVPEGEDPYIKKLVLQGKKYDLYVHSYLRYGR-EAFRAEIFKVAGGS--- 264
            S     +A + P+ E      L L G+ Y +Y HS+L YGR +  +  + KV       
Sbjct: 209 TS-----DAIEDPKNE----VMLKLYGQPYKVYTHSFLCYGRDQVLKRLLSKVLQAENYQ 259

Query: 265 ---ANPCILAGFDGAYTYS-------------GAEYKVSAPASGSNLNQCRKIALKALKV 308
              ANPC   G+  + + S             G     +   SG+       + +  L  
Sbjct: 260 ETVANPCWPTGYRKSLSLSSIYDSPCTEKERPGLPLNTTVVVSGTGNGNLCAVHVNKLFD 319

Query: 309 NAPCPYQNCTFGGIWNGGGGSGQKNLFLTSSFYYLSEDVGIFVNKPNAKIRPVDLKTAAK 368
              C + +C+F G++         N    S+F+Y  + +   + +P     P DLK AA+
Sbjct: 320 FTSCSFSHCSFDGVFQ---PEVSGNFIAFSAFFYTVDFIRTVMERPVHS--PSDLKDAAE 374

Query: 369 LACKTNLEDAKSKYPDLYEKDSVEYVCLDLVYVYTLLVDGFGLDPFQEVTVANEIEYQDA 428
             C T+  +   K P L EK   +Y C    +VY L+  G+  +     ++A + +  + 
Sbjct: 375 TICATSWNELYQKAPRL-EKRLPDY-CATSTFVYLLITKGYNFNNRSFPSIAFQKKAGET 432

Query: 429 LVEAAWPLGTAIEAISSLPKFE 450
            +   W LG  +   + +P  E
Sbjct: 433 SI--GWALGYMLNLTNMIPAQE 452


>ENP1_MOUSE (P55772) Ectonucleoside triphosphate diphosphohydrolase
           1 (EC 3.6.1.5) (NTPDase1) (Ecto-ATP diphosphohydrolase)
           (ATPDase) (Lymphoid cell activation antigen)
           (Ecto-apyrase) (CD39 antigen)
          Length = 510

 Score =  138 bits (348), Expect = 3e-32
 Identities = 115/450 (25%), Positives = 202/450 (44%), Gaps = 67/450 (14%)

Query: 36  LPKNQEPVTSYAVIFDAGSTGSRVHVYNFDQNLDL-LPVENELEFYDSVKPGLSSYAANP 94
           LP+N      Y ++ DAGS+ + +++Y +    +    V  +LE      PG+S YA   
Sbjct: 43  LPEN----VKYGIVLDAGSSHTNLYIYKWPAEKENDTGVVQQLEECQVKGPGISKYAQKT 98

Query: 95  EEAAESLIPLLKEAENVVPVSQQPNTPVKLGATAGLRLLEGNAAENILQAVRDMLSNRSA 154
           +E    L   ++ +  ++P S+   TPV LGATAG+RLL   + ++  + +  + ++  +
Sbjct: 99  DEIGAYLAECMELSTELIPTSKHHQTPVYLGATAGMRLLRMESEQSADEVLAAVSTSLKS 158

Query: 155 LNVQSDAVSILDGTQEGSYLWVTINYLLGKLGKRFT-----------KTVGVVDLGGGSV 203
                    I+ G +EG+Y W+TINYLLG+  +  +           +T G +DLGG S 
Sbjct: 159 YPFDFQGAKIITGQEEGAYGWITINYLLGRFTQEQSWLSLISDSQKQETFGALDLGGAST 218

Query: 204 QMTYAVSRNTAKNAPKVPEGEDPYIKKLVLQGKKYDLYVHSYLRYGREAF----RAEIFK 259
           Q+T+    +T ++    PE       +  L G+ Y +Y HS+L YG++       A+  +
Sbjct: 219 QITFVPQNSTIES----PENS----LQFRLYGEDYTVYTHSFLCYGKDQALWQKLAKDIQ 270

Query: 260 VAGGSA--NPCILAGFDGAYTYS-------GAEYKVSAP------ASGSNLNQCRKIALK 304
           V+ G    +PC   G++     S          ++   P          +  QC +  L+
Sbjct: 271 VSSGGVLKDPCFNPGYEKVVNVSELYGTPCTKRFEKKLPFDQFRIQGTGDYEQCHQSILE 330

Query: 305 ALKVNAPCPYQNCTFGGIW----NGGGGSGQKNLFLTSSFYYLSEDVGIFVNK--PNAKI 358
               N+ CPY  C F G++    +G  G+        S+FY++ +    F  K   N+ I
Sbjct: 331 LFN-NSHCPYSQCAFNGVFLPPLHGSFGA-------FSAFYFVMD----FFKKVAKNSVI 378

Query: 359 RPVDLKTAAKLACKTNLEDAKSKYPDLYEKDSVEYVCLDLVYVYTLLVD-GFGLDPFQEV 417
               +    K  C  + E+ K+ YP + EK   EY C    Y+ +LL    F    ++++
Sbjct: 379 SQEKMTEITKNFCSKSWEETKTSYPSVKEKYLSEY-CFSGAYILSLLQGYNFTDSSWEQI 437

Query: 418 TVANEIEYQDALVEAAWPLGTAIEAISSLP 447
               +I+  +    A W LG  +   + +P
Sbjct: 438 HFMGKIKDSN----AGWTLGYMLNLTNMIP 463


>MI23_CAEEL (Q21815) Nucleoside-diphosphatase mig-23 (EC 3.6.1.-)
           (NDPase) (Abnormal cell migration protein 23)
          Length = 552

 Score =  137 bits (344), Expect = 7e-32
 Identities = 123/447 (27%), Positives = 193/447 (42%), Gaps = 62/447 (13%)

Query: 45  SYAVIFDAGSTGSRVHVYNFDQNLDLLPVENELEFYDS------VKPGLSSYAANPEEAA 98
           SY VI DAGSTG+R+ VYN+    D   ++ E   YD+      + PGLS++   P +AA
Sbjct: 43  SYGVICDAGSTGTRLFVYNWISTSDSELIQIEPVIYDNKPVMKKISPGLSTFGTKPAQAA 102

Query: 99  ESLIPLLKEAENVVPVSQQPNTPVKLGATAGLRLLEGNAAENILQAVRDMLSNRSALNVQ 158
           E L PL++ AE  +P  ++P TPV + ATAG+RL+     E +L+ +R+ L   +++ V 
Sbjct: 103 EYLRPLMELAERHIPEEKRPYTPVFIFATAGMRLIPDEQKEAVLKNLRNKLPKITSMQVL 162

Query: 159 SDAVSILDGTQEGSYLWVTINYLLGKLGKRFT-------------KTVGVVDLGGGSVQM 205
            + + I++G  EG Y W+ +NY LGK  K  T             KTVG++D+GG S Q+
Sbjct: 163 KEHIRIIEGKWEGIYSWIAVNYALGKFNKTATLDFPGTSPAHARQKTVGMIDMGGASAQI 222

Query: 206 TYAVSRNTAKNAPKVPE-----GEDPYIKKLVLQGKKYDLYVHSYLRYG-------REAF 253
            + +    + ++  V        ED  +        KY L+V ++L YG        E  
Sbjct: 223 AFELPDTDSFSSINVENINLGCREDDSL-------FKYKLFVTTFLGYGVNEGIRKYEHM 275

Query: 254 RAEIFKVAGGSA--NPCILAGFDGAYTYSGAEYKVSAPASGSNLNQCRKIALKALKVNAP 311
                K   G+   + C+        T    E  V       N N C     K L   + 
Sbjct: 276 LLSKLKDQNGTVIQDDCMPLNLHKTVTLENGENFVR--RGTGNWNTCSNEVKKLLNPESS 333

Query: 312 ---CPYQ--NCTFGGIWNGGGGSGQKNLFLTSSFYYLSEDV-GIFVNKPNAKIRPVDLKT 365
              C  +   C FG +           ++  S ++Y + DV G+        I     + 
Sbjct: 334 SEVCKAEAAKCYFGAVPAPSIPLSNIEMYGFSEYWYSTHDVLGLGGQYDAENIAKKTQQY 393

Query: 366 AAKLACKTNLEDAKSKYPDLYEKDSVEYVCLDLVYVYTLLVDGFGLD----PFQEV-TVA 420
            +K       E  K  YP   +++ +   C    ++ ++L DGF +D     FQ V T+A
Sbjct: 394 CSKRWSTIQAESKKQLYPRA-DEERLRTQCFKSAWITSVLHDGFSVDKTHNKFQSVSTIA 452

Query: 421 NEIEYQDALVEAAWPLGTAIEAISSLP 447
            +        E  W LG  I  +   P
Sbjct: 453 GQ--------EVQWALGAMIYHMRFFP 471


>NTP1_CAEEL (Q18411) Putative nucleoside-triphosphatase ntp-1 (EC
           3.6.1.15)
          Length = 485

 Score =  129 bits (325), Expect = 1e-29
 Identities = 117/437 (26%), Positives = 192/437 (43%), Gaps = 61/437 (13%)

Query: 32  RKILLPKNQEPVTSYAVIFDAGSTGSRVHVYNFDQ------NLDLLPVENELEFYDSVKP 85
           R ++  KN      Y VI DAGS+G+R+ VY          N+D L  E+E      V P
Sbjct: 14  RSVVETKNN---IKYGVICDAGSSGTRLFVYTLKPLSGGLTNIDTLIHESE-PVVKKVTP 69

Query: 86  GLSSYAANPEEAAESLIPLLKEAENVVPVSQQPNTPVKLGATAGLRLLEGNAAENILQAV 145
           GLSS+   PE+  E L PLL+ AE  +P  Q   T + + ATAG+RLL     + I++ +
Sbjct: 70  GLSSFGDKPEQVVEYLTPLLRFAEEHIPYEQLGETDLLIFATAGMRLLPEAQKDAIIKNL 129

Query: 146 RDMLSNRSALNVQSDAVSILDGTQEGSYLWVTINYLLGKLGKRFTKTVGVVDLGGGSVQM 205
           ++ L + +AL V    + I+DG  EG Y W+ +NY+LG+  K     VG++D+GG SVQ+
Sbjct: 130 QNGLKSVTALRVSDSNIRIIDGAWEGIYSWIAVNYILGRFDKENDSKVGMIDMGGASVQI 189

Query: 206 TYAVSRNTAKNAPKVPEGEDPYIKKL----VLQGKKYDLYVHSYLRYGR----EAFRAEI 257
            + ++     N  +   G + Y   L      +  KY +Y  ++L YG     + +   +
Sbjct: 190 AFEIA-----NEKESYNGGNVYEINLGSIETNEDYKYKIYSTTFLGYGANEGLKKYENSL 244

Query: 258 FKVAGGSANPCILAGFD---GAYTYSG-AEYKVSAPASGSNLNQCRKIALKALKVNAPCP 313
            K +G S + C   G +   G +T +G  E+ V      S +           K    CP
Sbjct: 245 VK-SGNSNDSCSPRGLNRLIGEFTVNGTGEWDVCLAQVSSLIGD---------KAQPSCP 294

Query: 314 YQNCTFGGIWNGGGGSGQKNLFLTSSFYYLSEDVGIFVNKPNAKIRPVDLKTAAKLACKT 373
              C    +           L+  S ++Y + + G        +          +  C+ 
Sbjct: 295 NPTCFLRNVIAPSVNLSTVQLYGFSEYWYTTSNFG-----SGGEYHYQKFTDEVRKYCQK 349

Query: 374 NLED-----AKSKYPDLYEKDSVEYVCLDLVYVYTLLVDGFGLDP----FQEV-TVANEI 423
           +  D      ++++P+  + + +   C    +V ++L DGF +D     FQ V  +A E 
Sbjct: 350 DWNDIQDGFKRNEFPNA-DIERLGTNCFKAAWVTSVLHDGFNVDKTKHLFQSVLKIAGE- 407

Query: 424 EYQDALVEAAWPLGTAI 440
                  E  W LG  +
Sbjct: 408 -------EMQWALGAML 417


>ENP2_RAT (O35795) Ectonucleoside triphosphate diphosphohydrolase 2
           (EC 3.6.1.3) (NTPDase2) (Ecto-ATPase) (CD39 antigen-like
           1)
          Length = 495

 Score =  129 bits (325), Expect = 1e-29
 Identities = 113/445 (25%), Positives = 196/445 (43%), Gaps = 66/445 (14%)

Query: 40  QEPVTSYAVIFDAGSTGSRVHVYNF--DQNLDLLPVENELEFYDSVKPGLSSYAANPEEA 97
           + P   Y ++ DAGS+ + + VY +  D+  D   +  +    D    G+SSYA +P +A
Sbjct: 34  EPPALKYGIVLDAGSSHTSMFVYKWPADKENDT-GIVGQHSSCDVQGGGISSYANDPSKA 92

Query: 98  AESLIPLLKEAENVVPVSQQPNTPVKLGATAGLR---LLEGNAAENILQAVRDMLSNRSA 154
            +SL+  L++A   VP  +  +TP+ LGATAG+R   L    A   +L+AV   L+    
Sbjct: 93  GQSLVRCLEQALRDVPRDRHASTPLYLGATAGMRPFNLTSPEATARVLEAVTQTLTQ--- 149

Query: 155 LNVQSDAVSILDGTQEGSYLWVTINYLL---------GKLGKRFTKTVGVVDLGGGSVQM 205
                    IL G  EG + WVT NYLL         G+  +    T+G +DLGG S Q+
Sbjct: 150 YPFDFRGARILSGQDEGVFGWVTANYLLENFIKYGWVGRWIRPRKGTLGAMDLGGASTQI 209

Query: 206 TYAVSRNTAKNAPKVPEGEDPYIKKLVLQGKKYDLYVHSYLRYGREAFRAEIFKVA---- 261
           T+  +      +P    G + +++   L G+ Y +Y HS+L YGR+     +   A    
Sbjct: 210 TFETT------SPSEDPGNEVHLR---LYGQHYRVYTHSFLCYGRDQILLRLLASALQIH 260

Query: 262 --------GGSA---------NPCILAGFDGAYTYSGAEYKVSAPASGSNLNQCRKIALK 304
                   G S          +PC +     A+  S     + + +  SN   CR +  +
Sbjct: 261 RFHPCWPKGYSTQVLLQEVYQSPCTMGQRPRAFNGSA----IVSLSGTSNATLCRDLVSR 316

Query: 305 ALKVNAPCPYQNCTFGGIWNGGGGSGQKNLFLTSSFYYLSEDVGIFVNKPNAKIRPVDLK 364
              +++ CP+  C+F G++         N    S+FYY  + +   +  P   ++   L+
Sbjct: 317 LFNISS-CPFSQCSFNGVFQPPVAG---NFIAFSAFYYTVDFLTTVMGLPVGTLK--QLE 370

Query: 365 TAAKLACKTNLEDAKSKYPDLYEKDSVEYVCLDLVYVYTLLVDGFGLD--PFQEVTVANE 422
            A ++ C     + +++ P   +K  +   C   ++++ LL  G+  D   F+EV     
Sbjct: 371 EATEITCNQTWTELQARVPG--QKTRLADYCAVAMFIHQLLSRGYHFDERSFREVV---- 424

Query: 423 IEYQDALVEAAWPLGTAIEAISSLP 447
            + + A     W LG  +   + +P
Sbjct: 425 FQKKAADTAVGWALGYMLNLTNLIP 449


>ENP2_HUMAN (Q9Y5L3) Ectonucleoside triphosphate diphosphohydrolase
           2 (EC 3.6.1.3) (NTPDase2) (Ecto-ATPase) (CD39
           antigen-like 1)
          Length = 495

 Score =  128 bits (321), Expect = 3e-29
 Identities = 119/439 (27%), Positives = 192/439 (43%), Gaps = 54/439 (12%)

Query: 40  QEPVTSYAVIFDAGSTGSRVHVYNF--DQNLDLLPVENELEFYDSVKPGLSSYAANPEEA 97
           + P   Y ++ DAGS+ + + +Y +  D+  D   +  +    D    G+SSYA NP  A
Sbjct: 34  EPPALKYGIVLDAGSSHTSMFIYKWPADKENDT-GIVGQHSSCDVPGGGISSYADNPSGA 92

Query: 98  AESLIPLLKEAENVVPVSQQPNTPVKLGATAGLRLL---EGNAAENILQAVRDMLSNRSA 154
           ++SL+  L++A   VP  +   TP+ LGATAG+RLL      A+ ++L AV   L+    
Sbjct: 93  SQSLVGCLEQALQDVPKERHAGTPLYLGATAGMRLLNLTNPEASTSVLMAVTHTLTQ--- 149

Query: 155 LNVQSDAVSILDGTQEGSYLWVTINYLL------GKLGKRFTK---TVGVVDLGGGSVQM 205
                    IL G +EG + WVT NYLL      G +G+ F     T+G +DLGG S Q+
Sbjct: 150 YPFDFRGARILSGQEEGVFGWVTANYLLENFIKYGWVGRWFRPRKGTLGAMDLGGASTQI 209

Query: 206 TYAVSRNTAKNAPKVPEGEDPYIKKLVLQGKKYDLYVHSYLRYGREAFRAEIFKVA--GG 263
           T+  +      A +V         +L L G+ Y +Y HS+L YGR+     +   A    
Sbjct: 210 TFETTSPAEDRASEV---------QLHLYGQHYRVYTHSFLCYGRDQVLQRLLASALQTH 260

Query: 264 SANPCILAGFDGAYTYSGA------------EYKVSAPAS---GSNLNQCRKIALKALKV 308
             +PC   GF                      +  SA  S    S+ + CR + +  L  
Sbjct: 261 GFHPCWPRGFSTQVLLGDVYQSPCTMAQRPQNFNSSARVSLSGSSDPHLCRDL-VSGLFS 319

Query: 309 NAPCPYQNCTFGGIWNGGGGSGQKNLFLTSSFYYLSEDVGIFVNKPNAKIRPVDLKTAAK 368
            + CP+  C+F G++         N    S+F+Y  + +   +  P A ++   L+ AA 
Sbjct: 320 FSSCPFSRCSFNGVFQPPVAG---NFVAFSAFFYTVDFLRTSMGLPVATLQ--QLEAAAV 374

Query: 369 LACKTNLEDAKSKYPDLYEKDSVEYVCLDLVYVYTLLVDGFGLDPFQEVTVANEIEYQDA 428
             C       +++ P   ++  +   C   ++V  LL  G+G D      V  + +  D 
Sbjct: 375 NVCNQTWAQLQARVPG--QRARLADYCAGAMFVQQLLSRGYGFDERAFGGVIFQKKAADT 432

Query: 429 LVEAAWPLGTAIEAISSLP 447
            V   W LG  +   + +P
Sbjct: 433 AV--GWALGYMLNLTNLIP 449


  Database: sprot
    Posted date:  Nov 25, 2004 10:54 AM
  Number of letters in database: 59,974,054
  Number of sequences in database:  164,201
  
Lambda     K      H
   0.317    0.136    0.390 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 52,969,032
Number of Sequences: 164201
Number of extensions: 2335093
Number of successful extensions: 6518
Number of sequences better than 10.0: 50
Number of HSP's better than 10.0 without gapping: 30
Number of HSP's successfully gapped in prelim test: 20
Number of HSP's that attempted gapping in prelim test: 6373
Number of HSP's gapped (non-prelim): 54
length of query: 456
length of database: 59,974,054
effective HSP length: 114
effective length of query: 342
effective length of database: 41,255,140
effective search space: 14109257880
effective search space used: 14109257880
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)