BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= TM0098b.1
(696 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
SUV1_ARATH (Q9FF80) Histone-lysine N-methyltransferase, H3 lysin... 615 e-176
SUV3_ARATH (Q9C5P4) Histone-lysine N-methyltransferase, H3 lysin... 613 e-175
SUV7_ARATH (Q9C5P1) Histone-lysine N-methyltransferase, H3 lysin... 416 e-115
SUV8_ARATH (Q9C5P0) Histone-lysine N-methyltransferase, H3 lysin... 377 e-104
SUV5_ARATH (O82175) Histone-lysine N-methyltransferase, H3 lysin... 372 e-102
SUV6_ARATH (Q8VZ17) Histone-lysine N-methyltransferase, H3 lysin... 357 6e-98
SUV9_ARATH (Q9T0G7) Probable histone-lysine N-methyltransferase,... 351 3e-96
SUV2_ARATH (O22781) Probable histone-lysine N-methyltransferase,... 329 2e-89
SUV4_ARATH (Q8GZB6) Histone-lysine N-methyltransferase, H3 lysin... 308 3e-83
CLR4_SCHPO (O60016) Histone-lysine N-methyltransferase, H3 lysin... 147 7e-35
HMT1_HUMAN (Q9H9B1) Histone-lysine N-methyltransferase, H3 lysin... 137 1e-31
BAT8_MOUSE (Q9Z148) Histone-lysine N-methyltransferase, H3 lysin... 136 2e-31
BAT8_HUMAN (Q96KQ7) Histone-lysine N-methyltransferase, H3 lysin... 135 4e-31
SUV9_DROME (P45975) Histone-lysine N-methyltransferase, H3 lysin... 110 1e-23
SU91_HUMAN (O43463) Histone-lysine N-methyltransferase, H3 lysin... 110 1e-23
SU91_MOUSE (O54864) Histone-lysine N-methyltransferase, H3 lysin... 110 2e-23
SU92_HUMAN (Q9H5I1) Histone-lysine N-methyltransferase, H3 lysin... 105 4e-22
SEB2_HUMAN (Q96T68) Probable histone-lysine N-methyltransferase,... 102 4e-21
SETB_MOUSE (O88974) Histone-lysine N-methyltransferase, H3 lysin... 100 2e-20
SETB_HUMAN (Q15047) Histone-lysine N-methyltransferase, H3 lysin... 98 6e-20
>SUV1_ARATH (Q9FF80) Histone-lysine N-methyltransferase, H3 lysine-9
specific 1 (EC 2.1.1.43) (Histone H3-K9
methyltransferase 1) (H3-K9-HMTase 1) (Suppressor of
variegation 3-9 homolog 1) (Su(var)3-9 homolog 1)
Length = 670
Score = 615 bits (1587), Expect = e-176
Identities = 325/696 (46%), Positives = 434/696 (61%), Gaps = 53/696 (7%)
Query: 17 DKSRVLNVKPLRTLVPVFPSPSNPSSSATPQGGAPFVCVSPSGPFPSGVAPFYPFFVSPE 76
DK+RVL++KPLRTL PVFPS + PFVC P GPFP G + FYPF S
Sbjct: 10 DKTRVLDIKPLRTLRPVFPSGNQ---------APPFVCAPPFGPFPPGFSSFYPFSSSQA 60
Query: 77 SQRLSEQNAQTPTAQRAAPISAAVPINSFRTPTGATNGDVGSSRRKSRGQLPEDDNFVDL 136
+Q + N Q P + P+ + P A+ + + R R D+
Sbjct: 61 NQHTPDLNQAQYPPQHQQPQNPP-PVYQQQPPQHASEPSLVTPLRSFRSP--------DV 111
Query: 137 SEVDGEGGTGDGKRRKPQKRIREKRCSSDVDPDAVANEILKTINPGVFEILNQPDGSRDA 196
S + E KRR P+KR ++ G+ + ++ +G+R+
Sbjct: 112 SNGNAELEGSTVKRRIPKKR-------------PISRPENMNFESGI-NVADRENGNREL 157
Query: 197 VAYTLMIYEVMRRKLGQIDEKAKGSHSGAKRPDLKAGTLMNTKGIRANSRKRIGVVPGVE 256
V LM ++ +RR+ Q+++ + KRPDLK+G+ +G+R N++KR G+VPGVE
Sbjct: 158 VLSVLMRFDALRRRFAQLEDAKEAVSGIIKRPDLKSGSTCMGRGVRTNTKKRPGIVPGVE 217
Query: 257 VGDIFFFRFELCLVGLHAPSMAGIDYLGTKVSQEEEPLAVSIVSSGGYEDNVEDGDVLIY 316
+GD+FFFRFE+CLVGLH+PSMAGIDYL K EEEP+A SIVSSG Y+++ + DVLIY
Sbjct: 218 IGDVFFFRFEMCLVGLHSPSMAGIDYLVVKGETEEEPIATSIVSSGYYDNDEGNPDVLIY 277
Query: 317 SGQGGTS-REKGASDQKLERGNLALERSLHRGNDVRVIRGMRDEAHPTGKVYVYDGLYKI 375
+GQGG + ++K +SDQKLERGNLALE+SL R + VRVIRG+++ +H K+Y+YDGLY+I
Sbjct: 278 TGQGGNADKDKQSSDQKLERGNLALEKSLRRDSAVRVIRGLKEASH-NAKIYIYDGLYEI 336
Query: 376 QNSWVEKAKSGFNVFKYKLVRLPGQPQAYMIWKSILQWTDKSASRVGVILPDLTSGAEKL 435
+ SWVEK KSG N FKYKLVR PGQP A+ W +I +W SR G+ILPD+TSG E +
Sbjct: 337 KESWVEKGKSGHNTFKYKLVRAPGQPPAFASWTAIQKWKTGVPSRQGLILPDMTSGVESI 396
Query: 436 PVCLVNDVDNEKGPAYFTYSPTLKNLNRLAPVESSEGCTCNGGCQPGSHKCGCTQKNGGY 495
PV LVN+VD + GPAYFTYS T+K ++ S GC C C+PG+ C C +KNGG
Sbjct: 397 PVSLVNEVDTDNGPAYFTYSTTVKYSESFKLMQPSFGCDCANLCKPGNLDCHCIRKNGGD 456
Query: 496 LPYSAAGLLADLKSVVYECGPSCHCPPSCRNRVSQGGLKLRLEVFRTKGKGWGLRSWDPI 555
PY+ G+L K ++YEC PSC C +C+N+V+Q G+K+RLEVF+T +GWGLRSWD I
Sbjct: 457 FPYTGNGILVSRKPMIYECSPSCPC-STCKNKVTQMGVKVRLEVFKTANRGWGLRSWDAI 515
Query: 556 RAGTFICEYAGEVIDNARVEELSGENEDDYIFDSTRIYQQL-----------EVFSSDVE 604
RAG+FIC Y GE D ++V++ DDY FD+T +Y + E
Sbjct: 516 RAGSFICIYVGEAKDKSKVQQTMA--NDDYTFDTTNVYNPFKWNYEPGLADEDACEEMSE 573
Query: 605 APKIPSPLYITARNEGNVARFMNHSCTPNVLWRPVVRENKNEADLHVAFYAIRHIPPMME 664
+IP PL I+A+N GNVARFMNHSC+PNV W+PV EN ++ +HVAF+AI HIPPM E
Sbjct: 574 ESEIPLPLIISAKNVGNVARFMNHSCSPNVFWQPVSYENNSQLFVHVAFFAISHIPPMTE 633
Query: 665 LTYDYGIVLPLKVGQ-----KKKKCLCGSVKCRGYF 695
LTYDYG+ P K+KC CGS CRG F
Sbjct: 634 LTYDYGVSRPSGTQNGNPLYGKRKCFCGSAYCRGSF 669
>SUV3_ARATH (Q9C5P4) Histone-lysine N-methyltransferase, H3 lysine-9
specific 3 (EC 2.1.1.43) (Histone H3-K9
methyltransferase 3) (H3-K9-HMTase 3) (Suppressor of
variegation 3-9 homolog 3) (Su(var)3-9 homolog 3)
Length = 669
Score = 613 bits (1582), Expect = e-175
Identities = 337/709 (47%), Positives = 437/709 (61%), Gaps = 65/709 (9%)
Query: 6 GQDPAPAAGSFDKSRVLNVKPLRTLVPVFPSPSNPSSSATPQGGAPFVCVSPSGPFPSGV 65
G + P +DKS VL++KPLR+L PVFP+ + G PFV P GP S
Sbjct: 6 GFNTVPNPNHYDKSIVLDIKPLRSLKPVFPNGNQ---------GPPFVGCPPFGPSSSEY 56
Query: 66 APFYPFFVSPESQRLSEQNAQTPTAQRAAPISAAVP-INSFRTPTGATNGDVGSSRRKSR 124
+ F+PF + + N T PI + VP + S+RTPT TNG SS K
Sbjct: 57 SSFFPFGAQQPTHDTPDLNQTQNT-----PIPSFVPPLRSYRTPT-KTNGPSSSSGTKR- 109
Query: 125 GQLPEDDNFVDLSEVDGEGGTGDGKRRKPQKRIREKRCSSDVDPDA-VANEILKTINPGV 183
G G K K+ +K +++ + D V + + G+
Sbjct: 110 -------------------GVGRPKGTTSVKKKEKKTVANEPNLDVQVVKKFSSDFDSGI 150
Query: 184 FEILNQPDGSRDAVAYTLMIYEVMRRKLGQIDEKAKGSHSGAKRPDLKAGTLMNTKGIRA 243
+ DG+ V+ LM ++ +RR+L Q+ E K + S A AGTLM+ G+R
Sbjct: 151 -SAAEREDGNAYLVSSVLMRFDAVRRRLSQV-EFTKSATSKA------AGTLMSN-GVRT 201
Query: 244 NSRKRIGVVPGVEVGDIFFFRFELCLVGLHAPSMAGIDYLGTKVSQEEEPLAVSIVSSGG 303
N +KR+G VPG+EVGDIFF R E+CLVGLH +MAGIDY+ +K +EE LA SIVSSG
Sbjct: 202 NMKKRVGTVPGIEVGDIFFSRIEMCLVGLHMQTMAGIDYIISKAGSDEESLATSIVSSGR 261
Query: 304 YEDNVEDGDVLIYSGQGGTS-REKGASDQKLERGNLALERSLHRGNDVRVIRGMRDEAHP 362
YE +D + LIYSGQGG + + + ASDQKLERGNLALE SL +GN VRV+RG D A
Sbjct: 262 YEGEAQDPESLIYSGQGGNADKNRQASDQKLERGNLALENSLRKGNGVRVVRGEEDAASK 321
Query: 363 TGKVYVYDGLYKIQNSWVEKAKSGFNVFKYKLVRLPGQPQAYMIWKSILQWTDKSASRVG 422
TGK+Y+YDGLY I SWVEK KSG N FKYKLVR PGQP A+ WKS+ +W + +R G
Sbjct: 322 TGKIYIYDGLYSISESWVEKGKSGCNTFKYKLVRQPGQPPAFGFWKSVQKWKEGLTTRPG 381
Query: 423 VILPDLTSGAEKLPVCLVNDVDNEKGPAYFTYSPTLKNLNRLAPVESSEGCTCNGGCQPG 482
+ILPDLTSGAE PV LVNDVD +KGPAYFTY+ +LK + GC+C+G C PG
Sbjct: 382 LILPDLTSGAESKPVSLVNDVDEDKGPAYFTYTSSLKYSETFKLTQPVIGCSCSGSCSPG 441
Query: 483 SHKCGCTQKNGGYLPYSAAGLLADLKSVVYECGPSCHCPPSCRNRVSQGGLKLRLEVFRT 542
+H C C +KN G LPY +L + V+YECGP+C C SC+NRV Q GLK RLEVF+T
Sbjct: 442 NHNCSCIRKNDGDLPYLNGVILVSRRPVIYECGPTCPCHASCKNRVIQTGLKSRLEVFKT 501
Query: 543 KGKGWGLRSWDPIRAGTFICEYAGEVIDNARVEELSGENEDDYIFDSTRIYQQL------ 596
+ +GWGLRSWD +RAG+FICEYAGEV DN + + ED Y+FD++R++
Sbjct: 502 RNRGWGLRSWDSLRAGSFICEYAGEVKDNGNLR--GNQEEDAYVFDTSRVFNSFKWNYEP 559
Query: 597 EVFSSD--VEAPK---IPSPLYITARNEGNVARFMNHSCTPNVLWRPVVRENKNEADLHV 651
E+ D E P+ +PSPL I+A+ GNVARFMNHSC+PNV W+PV+RE E+ +H+
Sbjct: 560 ELVDEDPSTEVPEEFNLPSPLLISAKKFGNVARFMNHSCSPNVFWQPVIREGNGESVIHI 619
Query: 652 AFYAIRHIPPMMELTYDYGIVLPLKVGQK-----KKKCLCGSVKCRGYF 695
AF+A+RHIPPM ELTYDYGI + + ++ CLCGS +CRG F
Sbjct: 620 AFFAMRHIPPMAELTYDYGISPTSEARDESLLHGQRTCLCGSEQCRGSF 668
>SUV7_ARATH (Q9C5P1) Histone-lysine N-methyltransferase, H3 lysine-9
specific 7 (EC 2.1.1.43) (Histone H3-K9
methyltransferase 7) (H3-K9-HMTase 7) (Suppressor of
variegation 3-9 homolog 7) (Su(var)3-9 homolog 7)
Length = 693
Score = 416 bits (1069), Expect = e-115
Identities = 264/699 (37%), Positives = 367/699 (51%), Gaps = 75/699 (10%)
Query: 35 PSPSNPSSSATPQGGAPFVCVSPSGPFPSGVAPFY-----PFFVSPESQRLSEQNAQTPT 89
P+ +P + P +P + V P +Y P P + S+ T
Sbjct: 31 PTMVSPVLTNMPSATSPLLMVPPLRTIWPSNKEWYDGDAGPSSTGPIKREASDNTNDTAH 90
Query: 90 AQRAAPISAAVPINSFRTPTGATNGDVGSSRRKSRGQLPEDDNFVDLSEVDGEGGTGDGK 149
A P +P+ + R ++N + S G + G G K
Sbjct: 91 NTFAPPPEMVIPLITIRPSDDSSNYSCDAGAGPSTGPVKR-----------GRGRPKGSK 139
Query: 150 RRKPQKRIREKRCSSDVDPDAVANEILKTINPGVFEI----LNQPDGSRDAVAYTLMIYE 205
P + + K DP++ LK + G F+ G+++ V +M ++
Sbjct: 140 NSTPTEPKKPKV----YDPNS-----LKVTSRGNFDSEITEAETETGNQEIVDSVMMRFD 190
Query: 206 VMRRKLGQID--EKAKGSHSGAKRPDLKAGTLMNTKGIRANSRKRIGVVPGVEVGDIFFF 263
+RR+L QI+ E + SG G++ N+R+RIG VPG+ VGDIF++
Sbjct: 191 AVRRRLCQINHPEDILTTASGN----------CTKMGVKTNTRRRIGAVPGIHVGDIFYY 240
Query: 264 RFELCLVGLHAPSMAGIDYLGTKVSQEEEPLAVSIVSSGGYEDNVEDGDVLIYSGQGGTS 323
E+CLVGLH + GID+ S E A+ +V++G Y+ E D LIYSGQGGT
Sbjct: 241 WGEMCLVGLHKSNYGGIDFFTAAESAVEGHAAMCVVTAGQYDGETEGLDTLIYSGQGGTD 300
Query: 324 REKGASDQKLERGNLALERSLHRGNDVRVIRGMRDEAHPTGKVYVYDGLYKIQNSWVEKA 383
A DQ+++ GNLALE S+ +GNDVRV+RG+ K+Y+YDG+Y + W
Sbjct: 301 VYGNARDQEMKGGNLALEASVSKGNDVRVVRGVIHPHENNQKIYIYDGMYLVSKFWTVTG 360
Query: 384 KSGFNVFKYKLVRLPGQPQAYMIWKSI--LQWTDKSASRVGVILPDLTSGAEKLPVCLVN 441
KSGF F++KLVR P QP AY IWK++ L+ D SR G IL DL+ GAE L V LVN
Sbjct: 361 KSGFKEFRFKLVRKPNQPPAYAIWKTVENLRNHDLIDSRQGFILEDLSFGAELLRVPLVN 420
Query: 442 DVDNEKG--PAYFTYSPTLKNLNRLAPV----ESSEGCTCNGGCQPGSHK-CGCTQKNGG 494
+VD + P F Y P+ + + S GC N QP H+ C C Q+NG
Sbjct: 421 EVDEDDKTIPEDFDYIPSQCHSGMMTHEFHFDRQSLGCQ-NCRHQPCMHQNCTCVQRNGD 479
Query: 495 YLPYSAAGLLADLKSVVYECGPSCHCPPSCRNRVSQGGLKLRLEVFRTKGKGWGLRSWDP 554
LPY +L K ++YECG SC CP C R+ Q GLKL LEVF+T+ GWGLRSWDP
Sbjct: 480 LLPYH-NNILVCRKPLIYECGGSCPCPDHCPTRLVQTGLKLHLEVFKTRNCGWGLRSWDP 538
Query: 555 IRAGTFICEYAGEVIDNARVEELSGENEDDYIFDSTRIYQQL------EVFSSD-----V 603
IRAGTFICE+AG VEE +DDY+FD+++IYQ+ E+ D
Sbjct: 539 IRAGTFICEFAGLRKTKEEVEE-----DDDYLFDTSKIYQRFRWNYEPELLLEDSWEQVS 593
Query: 604 EAPKIPSPLYITARNEGNVARFMNHSCTPNVLWRPVVRENKNEADLHVAFYAIRHIPPMM 663
E +P+ + I+A+ +GNV RFMNHSC+PNV W+P+ EN+ + L + +A++HIPPM
Sbjct: 594 EFINLPTQVLISAKEKGNVGRFMNHSCSPNVFWQPIEYENRGDVYLLIGLFAMKHIPPMT 653
Query: 664 ELTYDYGIVL-------PLKVGQKKKKCLCGSVKCRGYF 695
ELTYDYG+ + + + KK CLCGSVKCRG F
Sbjct: 654 ELTYDYGVSCVERSEEDEVLLYKGKKTCLCGSVKCRGSF 692
>SUV8_ARATH (Q9C5P0) Histone-lysine N-methyltransferase, H3 lysine-9
specific 8 (EC 2.1.1.43) (Histone H3-K9
methyltransferase 8) (H3-K9-HMTase 8) (Suppressor of
variegation 3-9 homolog 8) (Su(var)3-9 homolog 8)
Length = 755
Score = 377 bits (968), Expect = e-104
Identities = 247/615 (40%), Positives = 331/615 (53%), Gaps = 67/615 (10%)
Query: 108 PTGATNGDVGSSRRKSRGQLPEDDNFVDLSE--VDGEGGTGDGKRRKPQKRIREKRCSSD 165
P G+ NG RK + D+N D S G G G+ + + R R+ +
Sbjct: 180 PKGSKNGS-----RKPKKPKAYDNNSTDASAGPSSGLGKRRCGRPKGLKNRSRKPKKPKA 234
Query: 166 VDPDAVANEILKTINPGVFEILNQPDGSRDAVAYTLMIYEVMRRKLGQIDEKAKGSHSGA 225
DP++ + + E + G+++ V LM ++ +RR+L Q++ +
Sbjct: 235 DDPNSKMVISCPDFDSRITEA-ERESGNQEIVDSILMRFDAVRRRLCQLNYR-------- 285
Query: 226 KRPDLKAGTLMNTKGIRANSRKRIGVVPGVEVGDIFFFRFELCLVGLHAPSMAGIDYLGT 285
K L A T G+R N +RIG +PGV+VGDIF++ E+CLVGLH + GID L
Sbjct: 286 KDKILTASTNCMNLGVRTNMTRRIGPIPGVQVGDIFYYWCEMCLVGLHRNTAGGIDSLLA 345
Query: 286 KVSQEEEPLAVSIVSSGGYEDNVEDGDVLIYSGQGGTSREKGASDQKLERGNLALERSLH 345
K S + P A S+V+SG Y++ ED + LIYSG GG DQ L+RGN ALE S+
Sbjct: 346 KESGVDGPAATSVVTSGKYDNETEDLETLIYSGHGGK-----PCDQVLQRGNRALEASVR 400
Query: 346 RGNDVRVIRGMRDEAHPTGKVYVYDGLYKIQNSWVEKAKSGFNVFKYKLVRLPGQPQAYM 405
R N+VRVIRG E + KVY+YDGLY + + W KSGF +++KL+R PGQP Y
Sbjct: 401 RRNEVRVIRG---ELYNNEKVYIYDGLYLVSDCWQVTGKSGFKEYRFKLLRKPGQPPGYA 457
Query: 406 IWKSI--LQWTDKSASRVGVILPDLTSGAEKLPVCLVNDVDNEKG--PAYFTY--SPTLK 459
IWK + L+ + R G IL DL+ G E L V LVN+VD E P F Y S
Sbjct: 458 IWKLVENLRNHELIDPRQGFILGDLSFGEEGLRVPLVNEVDEEDKTIPDDFDYIRSQCYS 517
Query: 460 NLNRLAPVESSEGCTCNGGCQPGSHK-CGCTQKNGGYLPYSAAGLLADLKSVVYECGPSC 518
+ V+S Q H+ C C KN G LPY +L K ++YECG
Sbjct: 518 GMTNDVNVDS------QSLVQSYIHQNCTCILKNCGQLPYH-DNILVCRKPLIYECG--- 567
Query: 519 HCPPSCRNRVSQGGLKLRLEVFRTKGKGWGLRSWDPIRAGTFICEYAGEVIDNARVEELS 578
SC R+ + GLKL LEVF+T GWGLRSWDPIRAGTFICE+ G VEE
Sbjct: 568 ---GSCPTRMVETGLKLHLEVFKTSNCGWGLRSWDPIRAGTFICEFTGVSKTKEEVEE-- 622
Query: 579 GENEDDYIFDSTRIYQQL------EVFSSDV-----EAPKIPSPLYITARNEGNVARFMN 627
+DDY+FD++RIY E+ D E +P+ + I+A+ +GNV RFMN
Sbjct: 623 ---DDDYLFDTSRIYHSFRWNYEPELLCEDACEQVSEDANLPTQVLISAKEKGNVGRFMN 679
Query: 628 HSCTPNVLWRPV-VRENKNEADLHVAFYAIRHIPPMMELTYDYGIVLPLKVGQK------ 680
H+C PNV W+P+ +N + + +A++HIPPM ELTYDYGI K G+
Sbjct: 680 HNCWPNVFWQPIEYDDNNGHIYVRIGLFAMKHIPPMTELTYDYGISCVEKTGEDEVIYKG 739
Query: 681 KKKCLCGSVKCRGYF 695
KK CLCGSVKCRG F
Sbjct: 740 KKICLCGSVKCRGSF 754
>SUV5_ARATH (O82175) Histone-lysine N-methyltransferase, H3 lysine-9
specific 5 (EC 2.1.1.43) (Histone H3-K9
methyltransferase 5) (H3-K9-HMTase 5) (Suppressor of
variegation 3-9 homolog 5) (Su(var)3-9 homolog 5)
Length = 794
Score = 372 bits (954), Expect = e-102
Identities = 220/564 (39%), Positives = 327/564 (57%), Gaps = 49/564 (8%)
Query: 143 GGTGDGKRRKPQKRIREKRCSSDVDPDAVANEILKTINPGVFEILNQPDGSRDAVAYTLM 202
G G+G RK +R+ +D +A++ + N G+ + D +R V T+
Sbjct: 264 GDYGEGSMRKNSERVA-------LDKKRLASKF-RLSNGGLPSCSSSGDSARYKVKETMR 315
Query: 203 IYEVMRRKLGQIDEKAKGSHSGAK-RPDLKAGTLMNTKGIRANSRKRI-GVVPGVEVGDI 260
++ +K+ Q +E G + +A ++ +KG S +I G VPGVEVGD
Sbjct: 316 LFHETCKKIMQEEEARPRKRDGGNFKVVCEASKILKSKGKNLYSGTQIIGTVPGVEVGDE 375
Query: 261 FFFRFELCLVGLHAPSMAGIDYLGTKVSQEEEPLAVSIVSSGGYEDNVEDGDVLIYSGQG 320
F +R EL L+G+H PS +GIDY+ E +A SIVSSGGY D +++ DVLIY+GQG
Sbjct: 376 FQYRMELNLLGIHRPSQSGIDYMK---DDGGELVATSIVSSGGYNDVLDNSDVLIYTGQG 432
Query: 321 GTSREKGAS----DQKLERGNLALERSLHRGNDVRVIRGMRD---EAHPTGKVYVYDGLY 373
G +K + DQ+L GNLAL+ S+++ N VRVIRG+++ ++ K YVYDGLY
Sbjct: 433 GNVGKKKNNEPPKDQQLVTGNLALKNSINKKNPVRVIRGIKNTTLQSSVVAKNYVYDGLY 492
Query: 374 KIQNSWVEKAKSGFNVFKYKLVRLPGQPQAYMIWKSILQWTDKSASRVGVILPDLTSGAE 433
++ W E G VFK+KL R+PGQP+ + WK + + + KS R G+ D+T G E
Sbjct: 493 LVEEYWEETGSHGKLVFKFKLRRIPGQPE--LPWKEVAK-SKKSEFRDGLCNVDITEGKE 549
Query: 434 KLPVCLVNDVDNEKGPAYFTYSPTLKNLNRLAPVESSEGCTCNGGCQPGSHKCGCTQKNG 493
LP+C VN++D+EK P F Y+ + + P+ + C C GC S C C KNG
Sbjct: 550 TLPICAVNNLDDEKPPP-FIYTAKMIYPDWCRPIPP-KSCGCTNGCSK-SKNCACIVKNG 606
Query: 494 GYLPYSAAGLLADLKSVVYECGPSCHCPPSCRNRVSQGGLKLRLEVFRTKGKGWGLRSWD 553
G +PY G + ++K +VYECGP C CPPSC RVSQ G+K++LE+F+T+ +GWG+RS +
Sbjct: 607 GKIPYYD-GAIVEIKPLVYECGPHCKCPPSCNMRVSQHGIKIKLEIFKTESRGWGVRSLE 665
Query: 554 PIRAGTFICEYAGEVIDNARVEELSGENEDDYIFDSTRIYQQLEVFSSDVEAPKIPSPLY 613
I G+FICEYAGE++++ + E L+G +D+Y+FD + D P
Sbjct: 666 SIPIGSFICEYAGELLEDKQAESLTG--KDEYLFD---------LGDED-------DPFT 707
Query: 614 ITARNEGNVARFMNHSCTPNVLWRPVVRENKNEADLHVAFYAIRHIPPMMELTYDYGI-- 671
I A +GN+ RF+NHSC+PN+ + V+ +++ H+ F+A+ +IPP+ EL+YDY
Sbjct: 708 INAAQKGNIGRFINHSCSPNLYAQDVLYDHEEIRIPHIMFFALDNIPPLQELSYDYNYKI 767
Query: 672 --VLPLKVGQKKKKCLCGSVKCRG 693
V KKK C CGS +C G
Sbjct: 768 DQVYDSNGNIKKKFCYCGSAECSG 791
>SUV6_ARATH (Q8VZ17) Histone-lysine N-methyltransferase, H3 lysine-9
specific 6 (EC 2.1.1.43) (Histone H3-K9
methyltransferase 6) (H3-K9-HMTase 6) (Suppressor of
variegation 3-9 homolog 6) (Su(var)3-9 homolog 6)
Length = 790
Score = 357 bits (916), Expect = 6e-98
Identities = 222/578 (38%), Positives = 315/578 (54%), Gaps = 48/578 (8%)
Query: 146 GDGKRRKPQKRIREKRCSSDVDPDAVANEILKTINPGVFEILNQPDGSRDAVAYTLMIYE 205
G+G R+K K+ R +D + E L+ + G + D SR+ V TL ++
Sbjct: 226 GEGSRKKKSKKNLYWRDRESLD----SPEQLRILGVGTSSGSSSGDSSRNKVKETLRLFH 281
Query: 206 VMRRKLGQIDEKAKGSHSGAK----RPDLKAGTLMNTKGIRANSRKRI-GVVPGVEVGDI 260
+ RK+ Q DE AK K R D +A T++ G NS I G VPGVEVGD
Sbjct: 282 GVCRKILQEDE-AKPEDQRRKGKGLRIDFEASTILKRNGKFLNSGVHILGEVPGVEVGDE 340
Query: 261 FFFRFELCLVGLHAPSMAGIDYLGTKVSQEEEPLAVSIVSSGGYEDNVEDGDVLIYSGQG 320
F +R EL ++G+H PS AGIDY+ + +A SIV+SGGY+D++++ DVL Y+GQG
Sbjct: 341 FQYRMELNILGIHKPSQAGIDYM----KYGKAKVATSIVASGGYDDHLDNSDVLTYTGQG 396
Query: 321 GTSRE--------KGASDQKLERGNLALERSLHRGNDVRVIRGMRDEAHPTGKV--YVYD 370
G + K DQKL GNLAL S+ + VRVIRG H K YVYD
Sbjct: 397 GNVMQVKKKGEELKEPEDQKLITGNLALATSIEKQTPVRVIRGKHKSTHDKSKGGNYVYD 456
Query: 371 GLYKIQNSWVEKAKSGFNVFKYKLVRLPGQPQAYMIWKSILQWTDKSASRVGVILPDLTS 430
GLY ++ W + G NVFK++L R+PGQP+ + W + + KS R G+ D++
Sbjct: 457 GLYLVEKYWQQVGSHGMNVFKFQLRRIPGQPE--LSWVEVKK--SKSKYREGLCKLDISE 512
Query: 431 GAEKLPVCLVNDVDNEKGPAYFTYSPTLKNLNRLAPVESSEGCTCNGGCQPGSHK-CGCT 489
G E+ P+ VN++D+EK P FTY+ L + PV + C C C + C C
Sbjct: 513 GKEQSPISAVNEIDDEK-PPLFTYTVKLIYPDWCRPVPP-KSCCCTTRCTEAEARVCACV 570
Query: 490 QKNGGYLPYSAAGLLADLKSVVYECGPSCHCPPSCRNRVSQGGLKLRLEVFRTKGKGWGL 549
+KNGG +PY+ G + K +YECGP C CP SC RV+Q G+KL LE+F+TK +GWG+
Sbjct: 571 EKNGGEIPYNFDGAIVGAKPTIYECGPLCKCPSSCYLRVTQHGIKLPLEIFKTKSRGWGV 630
Query: 550 RSWDPIRAGTFICEYAGEVIDNARVEELSGENEDDYIFDSTRIY-----QQLEVFSSDVE 604
R I G+FICEY GE+++++ E G D+Y+FD Y Q + +
Sbjct: 631 RCLKSIPIGSFICEYVGELLEDSEAERRIG--NDEYLFDIGNRYDNSLAQGMSELMLGTQ 688
Query: 605 APKI------PSPLYITARNEGNVARFMNHSCTPNVLWRPVVRENKNEADLHVAFYAIRH 658
A + S I A ++GNV RF+NHSC+PN+ + V+ ++++ HV F+A +
Sbjct: 689 AGRSMAEGDESSGFTIDAASKGNVGRFINHSCSPNLYAQNVLYDHEDSRIPHVMFFAQDN 748
Query: 659 IPPMMELTYDYGIVL----PLKVGQKKKKCLCGSVKCR 692
IPP+ EL YDY L K K+K C CG+ CR
Sbjct: 749 IPPLQELCYDYNYALDQVRDSKGNIKQKPCFCGAAVCR 786
>SUV9_ARATH (Q9T0G7) Probable histone-lysine N-methyltransferase, H3
lysine-9 specific 9 (EC 2.1.1.43) (Histone H3-K9
methyltransferase 9) (H3-K9-HMTase 9) (Suppressor of
variegation 3-9 homolog 9) (Su(var)3-9 homolog 9)
Length = 650
Score = 351 bits (901), Expect = 3e-96
Identities = 242/666 (36%), Positives = 344/666 (51%), Gaps = 70/666 (10%)
Query: 49 GAPFVCVSPS-GPFPSGVAPFYPFFVSPESQRLSEQNAQTPTAQRAAPISAAVPINSFRT 107
G+ + + PS P PS + P V+ +Q L+ Q P A IS+AV + T
Sbjct: 2 GSSHIPLDPSLNPSPSLIPKLEP--VTESTQNLA---FQLPNTNPQALISSAVSDFNEAT 56
Query: 108 PTGATNGDVGSSRRKSRGQ-LPEDDNFVDLSEVDGE--------------GGTGDG---- 148
+ V S R + Q L D+ L + G T D
Sbjct: 57 DFSSDYNTVAESARSAFAQRLQRHDDVAVLDSLTGAIVPVEENPEPEPNPYSTSDSSPSV 116
Query: 149 --KRRKPQKRIREKRCSSDVDPDAVANEILKTINPGVFEILNQPDGSRDAVAYTLMIYEV 206
+R +PQ R E +DV P++ R+ V T MIY+
Sbjct: 117 ATQRPRPQPRSSELVRITDVGPESERQ-------------------FREHVRKTRMIYDS 157
Query: 207 MRRKLGQIDEKAKGSHSGAKRPDLKAG---TLMNTKGIRANSRKRI-GVVPGVEVGDIFF 262
+R L + K G R D KAG ++M + N KRI G +PGV+VGDIFF
Sbjct: 158 LRMFLMMEEAKRNGVGGRRARADGKAGKAGSMMRDCMLWMNRDKRIVGSIPGVQVGDIFF 217
Query: 263 FRFELCLVGLHAPSMAGIDYLGTKVSQEEEPLAVSIVSSGGYEDNVEDGDVLIYSGQGGT 322
FRFELC++GLH +GID+L +S EP+A S++ SGGYED+ + GDV++Y+GQGG
Sbjct: 218 FRFELCVMGLHGHPQSGIDFLTGSLSSNGEPIATSVIVSGGYEDDDDQGDVIMYTGQGGQ 277
Query: 323 SR-EKGASDQKLERGNLALERSLHRGNDVRVIRGMRDEAHPTGKVYVYDGLYKIQNSWVE 381
R + A Q+LE GNLA+ERS++ G +VRVIRG++ E + +VYVYDGL++I +SW +
Sbjct: 278 DRLGRQAEHQRLEGGNLAMERSMYYGIEVRVIRGLKYENEVSSRVYVYDGLFRIVDSWFD 337
Query: 382 KAKSGFNVFKYKLVRLPGQPQ---AYMIWKSILQWTDKSASRVGVILPDLTSGAEKLPVC 438
KSGF VFKY+L R+ GQ + + + + L+ S G I D+++G E +PV
Sbjct: 338 VGKSGFGVFKYRLERIEGQAEMGSSVLKFARTLKTNPLSVRPRGYINFDISNGKENVPVY 397
Query: 439 LVNDVDNEKGPAYFTYSPTLKNLNRLAPVES--SEGCTCNGGCQPGSHKCGCTQKNGGYL 496
L ND+D+++ P Y+ Y L +S + GC C GC G C C KN G +
Sbjct: 398 LFNDIDSDQEPLYYEYLAQTSFPPGLFVQQSGNASGCDCVNGCGSG---CLCEAKNSGEI 454
Query: 497 PYSAAGLLADLKSVVYECGPSCHCPPSCRNRVSQGGLKLRLEVFRTKGKGWGLRSWDPIR 556
Y G L K +++ECG +C CPPSCRNRV+Q GL+ RLEVFR+ GWG+RS D +
Sbjct: 455 AYDYNGTLIRQKPLIHECGSACQCPPSCRNRVTQKGLRNRLEVFRSLETGWGVRSLDVLH 514
Query: 557 AGTFICEYAGEVIDNARVEELSGENEDDYI----FDSTR--IYQQLEVFSSDVEAPKIPS 610
AG FICEYAG + + L+ N D + F S R + L +D E P P
Sbjct: 515 AGAFICEYAGVALTREQANILT-MNGDTLVYPARFSSARWEDWGDLSQVLADFERPSYPD 573
Query: 611 ----PLYITARNEGNVARFMNHSCTPNVLWRPVVRENKNEADLHVAFYAIRHIPPMMELT 666
+ NVA +++HS PNV+ + V+ ++ + V +A +IPPM EL+
Sbjct: 574 IPPVDFAMDVSKMRNVACYISHSTDPNVIVQFVLHDHNSLMFPRVMLFAAENIPPMTELS 633
Query: 667 YDYGIV 672
DYG+V
Sbjct: 634 LDYGVV 639
>SUV2_ARATH (O22781) Probable histone-lysine N-methyltransferase, H3
lysine-9 specific 2 (EC 2.1.1.43) (Histone H3-K9
methyltransferase 2) (H3-K9-HMTase 2) (Suppressor of
variegation 3-9 homolog 2) (Su(var)3-9 homolog 2)
Length = 651
Score = 329 bits (843), Expect = 2e-89
Identities = 207/501 (41%), Positives = 281/501 (55%), Gaps = 33/501 (6%)
Query: 194 RDAVAYTLMIYEVMRRKLGQIDEKAKGSHSGA---KRPDLKAGTLMNTKGIRANSRKRI- 249
R + T M YE +R L + E K G +R D+ A +M +G+ N K I
Sbjct: 149 RQVMKRTRMTYESLRIHL--MAESMKNHVLGQGRRRRSDMAAAYIMRDRGLWLNYDKHIV 206
Query: 250 GVVPGVEVGDIFFFRFELCLVGLHAPSMAGIDYLGTKVSQEEEPLAVSIVSSGGYEDNVE 309
G V GVEVGDIFF+R ELC++GLH + AGID L + S EP+A SIV SGGYED+ +
Sbjct: 207 GPVTGVEVGDIFFYRMELCVLGLHGQTQAGIDCLTAERSATGEPIATSIVVSGGYEDDED 266
Query: 310 DGDVLIYSGQGGTSRE-KGASDQKLERGNLALERSLHRGNDVRVIRGMRDEAHPTGKVYV 368
GDVL+Y+G GG + K +Q+L GNL +ERS+H G +VRVIRG++ E + KVYV
Sbjct: 267 TGDVLVYTGHGGQDHQHKQCDNQRLVGGNLGMERSMHYGIEVRVIRGIKYENSISSKVYV 326
Query: 369 YDGLYKIQNSWVEKAKSGFNVFKYKLVRLPGQPQ---AYMIWKSILQWTDKSASRVGVIL 425
YDGLYKI + W KSGF VFK++LVR+ GQP A M + L+ G +
Sbjct: 327 YDGLYKIVDWWFAVGKSGFGVFKFRLVRIEGQPMMGSAVMRFAQTLRNKPSMVRPTGYVS 386
Query: 426 PDLTSGAEKLPVCLVNDVDNEKGPAYFTY------SPTLKNLNRLAPVESSEGCTCNGGC 479
DL++ E +PV L NDVD ++ P ++ Y P + + S GC C C
Sbjct: 387 FDLSNKKENVPVFLYNDVDGDQEPRHYEYIAKAVFPPGIFGQGGI----SRTGCECKLSC 442
Query: 480 QPGSHKCGCTQKNGGYLPYSAAGLLADLKSVVYECGPSCHCPPSCRNRVSQGGLKLRLEV 539
+ C C +KNGG Y G L K VV+ECG C C PSC++RV+Q GL+ RLEV
Sbjct: 443 ---TDDCLCARKNGGEFAYDDNGHLLKGKHVVFECGEFCTCGPSCKSRVTQKGLRNRLEV 499
Query: 540 FRTKGKGWGLRSWDPIRAGTFICEYAGEVIDNARVEELSGENEDDYIF-----DSTRIYQ 594
FR+K GWG+R+ D I AG FICEYAG V+ + E LS N D ++ D R +
Sbjct: 500 FRSKETGWGVRTLDLIEAGAFICEYAGVVVTRLQAEILS-MNGDVMVYPGRFTDQWRNWG 558
Query: 595 QLEVFSSDVEAPKIPS--PL--YITARNEGNVARFMNHSCTPNVLWRPVVRENKNEADLH 650
L D P PS PL + NVA +++HS PNV+ + V+ ++ +
Sbjct: 559 DLSQVYPDFVRPNYPSLPPLDFSMDVSRMRNVACYISHSKEPNVMVQFVLHDHNHLMFPR 618
Query: 651 VAFYAIRHIPPMMELTYDYGI 671
V +A+ +I P+ EL+ DYG+
Sbjct: 619 VMLFALENISPLAELSLDYGL 639
>SUV4_ARATH (Q8GZB6) Histone-lysine N-methyltransferase, H3 lysine-9
specific 4 (EC 2.1.1.43) (Histone H3-K9
methyltransferase 4) (H3-K9-HMTase 4) (Suppressor of
variegation 3-9 homolog 4) (Su(var)3-9 homolog 4)
(KRYPTONITE protein)
Length = 624
Score = 308 bits (789), Expect = 3e-83
Identities = 194/503 (38%), Positives = 266/503 (52%), Gaps = 45/503 (8%)
Query: 227 RPDLKAGTLMNTKGIRANSRKRIGVVPGVEVGDIFFFRFELCLVGLHAPSMAGIDYLGTK 286
RPDLK T M RK IG +PG++VG FF R E+C VG H + GIDY+ +
Sbjct: 126 RPDLKGVTEMIKAKAILYPRKIIGDLPGIDVGHRFFSRAEMCAVGFHNHWLNGIDYMSME 185
Query: 287 VSQEEE----PLAVSIVSSGGYEDNVEDGDVLIYSGQGG---TSREKGASDQKLERGNLA 339
+E PLAVSIV SG YED++++ D + Y+GQGG T ++ DQ LERGNLA
Sbjct: 186 YEKEYSNYKLPLAVSIVMSGQYEDDLDNADTVTYTGQGGHNLTGNKRQIKDQLLERGNLA 245
Query: 340 LERSLHRGNDVRVIRGMRDEAHPTGKVYVYDGLYKIQNSWVEKAKSGFNVFKYKLVRLPG 399
L+ VRV RG ++ T +VY YDGLYK++ W +K SGF V+KY+L RL G
Sbjct: 246 LKHCCEYNVPVRVTRGHNCKSSYTKRVYTYDGLYKVEKFWAQKGVSGFTVYKYRLKRLEG 305
Query: 400 QPQAYMIWKSILQWT-DKSASRV-GVILPDLTSGAEKLPVCLVNDVDNE--KGPAYFTYS 455
QP+ + + S S + G++ D++ G E + N VD+ + FTY
Sbjct: 306 QPELTTDQVNFVAGRIPTSTSEIEGLVCEDISGGLEFKGIPATNRVDDSPVSPTSGFTYI 365
Query: 456 PTLKNLNRLAPVESSEGCTCNGGCQPGSHKCGCTQKNGGYLPYSAA--GLLADLKSVVYE 513
+L + +SS GC C G C S KC C + NGG PY G L + + VV+E
Sbjct: 366 KSLIIEPNVIIPKSSTGCNCRGSCTD-SKKCACAKLNGGNFPYVDLNDGRLIESRDVVFE 424
Query: 514 CGPSCHCPPSCRNRVSQGGLKLRLEVFRTKGKGWGLRSWDPIRAGTFICEYAGEVIDNAR 573
CGP C C P C NR SQ L+ LEVFR+ KGW +RSW+ I AG+ +CEY G V A
Sbjct: 425 CGPHCGCGPKCVNRTSQKRLRFNLEVFRSAKKGWAVRSWEYIPAGSPVCEYIGVVRRTAD 484
Query: 574 VEELSGENEDDYIFD--------------------STRIYQQLEVFSSDVEAPKIPSPLY 613
V+ +S +++YIF+ + + + S D AP+
Sbjct: 485 VDTIS---DNEYIFEIDCQQTMQGLGGRQRRLRDVAVPMNNGVSQSSEDENAPE----FC 537
Query: 614 ITARNEGNVARFMNHSCTPNVLWRPVVRENKNEADLHVAFYAIRHIPPMMELTYDYGIVL 673
I A + GN ARF+NHSC PN+ + V+ +++ V +A +I PM ELTYDYG L
Sbjct: 538 IDAGSTGNFARFINHSCEPNLFVQCVLSSHQDIRLARVVLFAADNISPMQELTYDYGYAL 597
Query: 674 PLKVGQ----KKKKCLCGSVKCR 692
G K+ C CG++ CR
Sbjct: 598 DSVHGPDGKVKQLACYCGALNCR 620
>CLR4_SCHPO (O60016) Histone-lysine N-methyltransferase, H3 lysine-9
specific (EC 2.1.1.43) (Histone H3-K9 methyltransferase)
(H3-K9-HMTase) (Cryptic loci regulator 4)
Length = 490
Score = 147 bits (372), Expect = 7e-35
Identities = 98/281 (34%), Positives = 141/281 (49%), Gaps = 37/281 (13%)
Query: 437 VCLVNDVDNEKGPAY-FTYSPTLKNLNRLAPVESS--EGCTCN--GGCQPGS-HKCGCTQ 490
V LVN+VD+E P+ F + + + P + + GC C+ GGC + +C C
Sbjct: 221 VTLVNEVDDEPCPSLDFQFISQYRLTQGVIPPDPNFQSGCNCSSLGGCDLNNPSRCECLD 280
Query: 491 K--NGGYLPYSAAGLL-ADLKSVVYECGPSCHCPPSCRNRVSQGGLKLRLEVFRTKGKGW 547
+ Y A G + AD +V+YEC C C C NRV Q G L LE+F+TK KGW
Sbjct: 281 DLDEPTHFAYDAQGRVRADTGAVIYECNSFCSCSMECPNRVVQRGRTLPLEIFKTKEKGW 340
Query: 548 GLRSWDPIRAGTFICEYAGEVIDNARVEELSGENEDD---YIFDSTRIYQQLEVFSSDVE 604
G+RS AGTFI Y GEVI +A + +DD Y+FD L++F
Sbjct: 341 GVRSLRFAPAGTFITCYLGEVITSAEAAKRDKNYDDDGITYLFD-------LDMFDD--- 390
Query: 605 APKIPSPLYITARNEGNVARFMNHSCTPNVLWRPVVRENKNEADLHVAFYAIRHIPPMME 664
S + A+N G+V+RF NHSC+PN+ VR + +AF+AI+ I P+ E
Sbjct: 391 ----ASEYTVDAQNYGDVSRFFNHSCSPNIAIYSAVRNHGFRTIYDLAFFAIKDIQPLEE 446
Query: 665 LTYDYGIVLPL-----------KVGQKKKKCLCGSVKCRGY 694
LT+DY ++ + +++C CGS CRG+
Sbjct: 447 LTFDYAGAKDFSPVQSQKSQQNRISKLRRQCKCGSANCRGW 487
>HMT1_HUMAN (Q9H9B1) Histone-lysine N-methyltransferase, H3 lysine-9
specific 5 (EC 2.1.1.43) (Histone H3-K9 methyltransferase
5) (H3-K9-HMTase 5) (Euchromatic histone
methyltransferase 1) (Eu-HMTase1) (G9a-like protein 1)
(GLP1)
Length = 1267
Score = 137 bits (344), Expect = 1e-31
Identities = 91/280 (32%), Positives = 139/280 (49%), Gaps = 34/280 (12%)
Query: 423 VILPDLTSGAEKLPVCLVNDVDNEKGPAYFTY---SPTLKNLNRLAPVESSEGCTCNGGC 479
++ D+ G E++P+ VN VD+E P+ + Y + +N + + C C C
Sbjct: 978 IVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDC 1037
Query: 480 QPGSHKCGCTQ------KNGGYLP-YSAAGLLADLKSVVYECGPSCHCPPSCRNRVSQGG 532
+ CG K+G LP ++ A +++EC +C C +CRNRV Q G
Sbjct: 1038 SSSNCMCGQLSMRCWYDKDGRLLPEFNMAE-----PPLIFECNHACSCWRNCRNRVVQNG 1092
Query: 533 LKLRLEVFRTKGKGWGLRSWDPIRAGTFICEYAGEVIDNARVEELSGENEDDYIFDSTRI 592
L+ RL+++RT+ GWG+RS I GTF+CEY GE+I ++ E ED Y+FD
Sbjct: 1093 LRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDS---EADVREEDSYLFDLDN- 1148
Query: 593 YQQLEVFSSDVEAPKIPSPLYITARNEGNVARFMNHSCTPNVLWRPVVRENKNEADLHVA 652
+ EV+ D AR GNV+RF+NH C PN++ V +++ +A
Sbjct: 1149 -KDGEVYCID-------------ARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIA 1194
Query: 653 FYAIRHIPPMMELTYDYGIVLPLKVGQKKKKCLCGSVKCR 692
F++ R I +L +DYG + K C CGS KCR
Sbjct: 1195 FFSTRLIEAGEQLGFDYGERF-WDIKGKLFSCRCGSPKCR 1233
>BAT8_MOUSE (Q9Z148) Histone-lysine N-methyltransferase, H3 lysine-9
specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase
3) (H3-K9-HMTase 3) (HLA-B associated transcript 8) (G9a)
(NG36)
Length = 1263
Score = 136 bits (343), Expect = 2e-31
Identities = 92/280 (32%), Positives = 135/280 (47%), Gaps = 34/280 (12%)
Query: 423 VILPDLTSGAEKLPVCLVNDVDNEKGPAYFTY-----SPTLKNLNRLAPVESSEGCTCNG 477
+I D+ G E +P+ VN VD E P + Y + N++R + + CTC
Sbjct: 974 IICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDR--NITHLQHCTCVD 1031
Query: 478 GCQPGSHKCG-----CTQKNGGYLPYSAAGLLADLKSVVYECGPSCHCPPSCRNRVSQGG 532
C + CG C G L + L ++EC +C C SC+NRV Q G
Sbjct: 1032 DCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPL---IFECNQACSCWRSCKNRVVQSG 1088
Query: 533 LKLRLEVFRTKGKGWGLRSWDPIRAGTFICEYAGEVIDNARVEELSGENEDDYIFDSTRI 592
+K+RL+++RT GWG+R+ I GTFICEY GE+I +A E +D Y+FD
Sbjct: 1089 IKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDA---EADVREDDSYLFDLDN- 1144
Query: 593 YQQLEVFSSDVEAPKIPSPLYITARNEGNVARFMNHSCTPNVLWRPVVRENKNEADLHVA 652
+ EV+ D AR GN++RF+NH C PN++ V +++ +A
Sbjct: 1145 -KDGEVYCID-------------ARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIA 1190
Query: 653 FYAIRHIPPMMELTYDYGIVLPLKVGQKKKKCLCGSVKCR 692
F++ R I EL +DYG + K C CGS KC+
Sbjct: 1191 FFSSRDIRTGEELGFDYGDRF-WDIKSKYFTCQCGSEKCK 1229
>BAT8_HUMAN (Q96KQ7) Histone-lysine N-methyltransferase, H3 lysine-9
specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase
3) (H3-K9-HMTase 3) (HLA-B associated transcript 8) (G9a)
(NG36)
Length = 1210
Score = 135 bits (340), Expect = 4e-31
Identities = 91/280 (32%), Positives = 135/280 (47%), Gaps = 34/280 (12%)
Query: 423 VILPDLTSGAEKLPVCLVNDVDNEKGPAYFTY-----SPTLKNLNRLAPVESSEGCTCNG 477
+I D+ G E +P+ VN VD E P + Y + N++R + + CTC
Sbjct: 921 IICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDR--NITHLQHCTCVD 978
Query: 478 GCQPGSHKCG-----CTQKNGGYLPYSAAGLLADLKSVVYECGPSCHCPPSCRNRVSQGG 532
C + CG C G L + L ++EC +C C +C+NRV Q G
Sbjct: 979 DCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPL---IFECNQACSCWRNCKNRVVQSG 1035
Query: 533 LKLRLEVFRTKGKGWGLRSWDPIRAGTFICEYAGEVIDNARVEELSGENEDDYIFDSTRI 592
+K+RL+++RT GWG+R+ I GTFICEY GE+I +A E +D Y+FD
Sbjct: 1036 IKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDA---EADVREDDSYLFDLDN- 1091
Query: 593 YQQLEVFSSDVEAPKIPSPLYITARNEGNVARFMNHSCTPNVLWRPVVRENKNEADLHVA 652
+ EV+ D AR GN++RF+NH C PN++ V +++ +A
Sbjct: 1092 -KDGEVYCID-------------ARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIA 1137
Query: 653 FYAIRHIPPMMELTYDYGIVLPLKVGQKKKKCLCGSVKCR 692
F++ R I EL +DYG + K C CGS KC+
Sbjct: 1138 FFSSRDIRTGEELGFDYGDRF-WDIKSKYFTCQCGSEKCK 1176
>SUV9_DROME (P45975) Histone-lysine N-methyltransferase, H3 lysine-9
specific (EC 2.1.1.43) (Histone H3-K9 methyltransferase)
(H3-K9-HMTase) (Suppressor of variegation protein 3-9)
Length = 635
Score = 110 bits (276), Expect = 1e-23
Identities = 83/269 (30%), Positives = 124/269 (45%), Gaps = 23/269 (8%)
Query: 436 PVCLVNDVDNEKGPAYFTY-SPTLKNLNRLAPVESSEGCTCNGGCQP--GSHKCGCTQKN 492
P+ + N++D + + F Y + + P GC C + S KC C +
Sbjct: 374 PIRVENNIDLDTIDSNFMYIHDNIIGKDVPKPEAGIVGCKCTEDTEECTASTKC-CARFA 432
Query: 493 GGYLPYSAAGLLADLK--SVVYECGPSCHCPPSCRNRVSQGGLKLRLEVFRT-KGKGWGL 549
G Y + L+ S +YEC C C SC NR+ Q G ++ L +F+T G GWG+
Sbjct: 433 GELFAYERSTRRLRLRPGSAIYECNSRCSCDSSCSNRLVQHGRQVPLVLFKTANGSGWGV 492
Query: 550 RSWDPIRAGTFICEYAGEVIDNARVEELSGENEDDYIFDSTRIYQQLEVFSSDVEAPKIP 609
R+ +R G F+CEY GE+I + E G+ DD + R Y +F D +
Sbjct: 493 RAATALRKGEFVCEYIGEIITSDEANE-RGKAYDD----NGRTY----LFDLDYNTAQ-D 542
Query: 610 SPLYITARNEGNVARFMNHSCTPNVLWRPVVRENKNEADLHVAFYAIRHIPPMMELTYDY 669
S I A N GN++ F+NHSC PN+ P E+ N A H+ F+ +R I EL++DY
Sbjct: 543 SEYTIDAANYGNISHFINHSCDPNLAVFPCWIEHLNVALPHLVFFTLRPIKAGEELSFDY 602
Query: 670 ------GIVLPLKVGQKKKKCLCGSVKCR 692
+ + +C CG CR
Sbjct: 603 IRADNEDVPYENLSTAVRVECRCGRDNCR 631
>SU91_HUMAN (O43463) Histone-lysine N-methyltransferase, H3 lysine-9
specific 1 (EC 2.1.1.43) (Histone H3-K9
methyltransferase 1) (H3-K9-HMTase 1) (Suppressor of
variegation 3-9 homolog 1) (Su(var)3-9 homolog 1)
Length = 412
Score = 110 bits (276), Expect = 1e-23
Identities = 88/291 (30%), Positives = 131/291 (44%), Gaps = 58/291 (19%)
Query: 437 VCLVNDVDNEKGPAYFTYSPTLKNLNRLAPVESSEGCTCN-------GGCQPGS--HKCG 487
+ + N+VD + P F Y + + + + GC C GGC PG+ HK
Sbjct: 145 ITVENEVDLDGPPRAFVYINEYRVGEGITLNQVAVGCECQDCLWAPTGGCCPGASLHKFA 204
Query: 488 CTQKNGGYLPYSAAGLLADLKSVVYECGPSCHCPPSCRNRVSQGGLKLRLEVFRTK-GKG 546
+ L AGL +YEC C C C NRV Q G++ L +FRT G+G
Sbjct: 205 YNDQGQVRL---RAGL------PIYECNSRCRCGYDCPNRVVQKGIRYDLCIFRTDDGRG 255
Query: 547 WGLRSWDPIRAGTFICEYAGEVIDNARVE---ELSGENEDDYIFDSTRIYQQLEVFSSDV 603
WG+R+ + IR +F+ EY GE+I + E ++ Y+FD + +V++ D
Sbjct: 256 WGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDYVE---DVYTVD- 311
Query: 604 EAPKIPSPLYITARNEGNVARFMNHSCTPNVLWRPVVRENKNEADLHVAFYAIRHIPPMM 663
A GN++ F+NHSC PN+ V +N +E +AF+A R I
Sbjct: 312 ------------AAYYGNISHFVNHSCDPNLQVYNVFIDNLDERLPRIAFFATRTIRAGE 359
Query: 664 ELTYDYGI-VLPLKV---------------GQKKKK----CLCGSVKCRGY 694
ELT+DY + V P+ + G KK+ C CG+ CR Y
Sbjct: 360 ELTFDYNMQVDPVDMESTRMDSNFGLAGLPGSPKKRVRIECKCGTESCRKY 410
>SU91_MOUSE (O54864) Histone-lysine N-methyltransferase, H3 lysine-9
specific 1 (EC 2.1.1.43) (Histone H3-K9
methyltransferase 1) (H3-K9-HMTase 1) (Suppressor of
variegation 3-9 homolog 1) (Su(var)3-9 homolog 1)
(Position-effect variegation 3-9 homolog)
Length = 412
Score = 110 bits (274), Expect = 2e-23
Identities = 84/289 (29%), Positives = 128/289 (44%), Gaps = 54/289 (18%)
Query: 437 VCLVNDVDNEKGPAYFTYSPTLKNLNRLAPVESSEGCTCN-------GGCQPGSHKCGCT 489
+ + N+VD + P F Y + + + + GC C GGC PG+
Sbjct: 145 ITVENEVDLDGPPRSFVYINEYRVGEGITLNQVAVGCECQDCLLAPTGGCCPGASLHKFA 204
Query: 490 QKNGGYLPYSAAGLLADLKSVVYECGPSCHCPPSCRNRVSQGGLKLRLEVFRTK-GKGWG 548
+ G + A +YEC C C C NRV Q G++ L +FRT G+GWG
Sbjct: 205 YNDQGQVRLKAG-------QPIYECNSRCCCGYDCPNRVVQKGIRYDLCIFRTNDGRGWG 257
Query: 549 LRSWDPIRAGTFICEYAGEVIDNARVE---ELSGENEDDYIFDSTRIYQQLEVFSSDVEA 605
+R+ + IR +F+ EY GE+I + E ++ Y+FD + +V++ D
Sbjct: 258 VRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDYVE---DVYTVD--- 311
Query: 606 PKIPSPLYITARNEGNVARFMNHSCTPNVLWRPVVRENKNEADLHVAFYAIRHIPPMMEL 665
A GN++ F+NHSC PN+ V +N +E +AF+A R I EL
Sbjct: 312 ----------AAYYGNISHFVNHSCDPNLQVYNVFIDNLDERLPRIAFFATRTIWAGEEL 361
Query: 666 TYDYGI-VLPLKV---------------GQKKKK----CLCGSVKCRGY 694
T+DY + V P+ + G KK+ C CG+ CR Y
Sbjct: 362 TFDYNMQVDPVDMESTRMDSNFGLAGLPGSPKKRVRIECKCGTTACRKY 410
>SU92_HUMAN (Q9H5I1) Histone-lysine N-methyltransferase, H3 lysine-9
specific 2 (EC 2.1.1.43) (Histone H3-K9
methyltransferase 2) (H3-K9-HMTase 2) (Suppressor of
variegation 3-9 homolog 2) (Su(var)3-9 homolog 2)
Length = 410
Score = 105 bits (262), Expect = 4e-22
Identities = 83/268 (30%), Positives = 123/268 (44%), Gaps = 31/268 (11%)
Query: 441 NDVDNEKGPAYFTYSPTLKNLNRLAPV-ESSEGCTCNGGCQPGSHKCGCTQKNGGYLPYS 499
N VD E P+ F Y K ++ V E++ GC+C KC C + G L Y+
Sbjct: 158 NTVDLEGPPSDFYYINEYKPAPGISLVNEATFGCSCTDCF---FQKC-CPAEAGVLLAYN 213
Query: 500 A-AGLLADLKSVVYECGPSCHCPPSCRNRVSQGGLKLRLEVFRTK-GKGWGLRSWDPIRA 557
+ + +YEC C C P C NR+ Q G + L +FRT G+GWG+++ I+
Sbjct: 214 KNQQIKIPPGTPIYECNSRCQCGPDCPNRIVQKGTQYSLCIFRTSNGRGWGVKTLVKIKR 273
Query: 558 GTFICEYAGEVIDNARVEELSGENEDDYIFDSTRIYQQLEVFSSDVEAPKIPSPLYITAR 617
+F+ EY GEVI + E +D+ I +F D E+ + + A
Sbjct: 274 MSFVMEYVGEVITSEEAERRG------QFYDNKGITY---LFDLDYESDEFT----VDAA 320
Query: 618 NEGNVARFMNHSCTPNVLWRPVVRENKNEADLHVAFYAIRHIPPMMELTYDY-----GIV 672
GNV+ F+NHSC PN+ V +N + +A ++ R I ELT+DY G +
Sbjct: 321 RYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFSTRTINAGEELTFDYQMKGSGDI 380
Query: 673 LPLKVGQKKKK------CLCGSVKCRGY 694
+ K C CG+V CRGY
Sbjct: 381 SSDSIDHSPAKKRVRTVCKCGAVTCRGY 408
>SEB2_HUMAN (Q96T68) Probable histone-lysine N-methyltransferase, H3
lysine-9 specific (EC 2.1.1.43) (Histone H3-K9
methyltransferase) (H3-K9-HMTase) (SET domain bifurcated
2) (Chronic lymphocytic leukemia deletion region gene 8
protein)
Length = 719
Score = 102 bits (253), Expect = 4e-21
Identities = 74/228 (32%), Positives = 111/228 (48%), Gaps = 31/228 (13%)
Query: 427 DLTSGAEKLPVCLVNDVDNEKGPAYF---TYSPTLKNLNRLAPVESSEGCTCNGGCQPGS 483
D+++G E +P+ N++D+ K P + T P NL + + ++ C C+ GC +
Sbjct: 245 DISNGVESVPISFCNEIDSRKLPQFKYRKTVWPRAYNLTNFSSM-FTDSCDCSEGCIDIT 303
Query: 484 HKCGCTQ---KNGGYLPYSAAGLLADLK---------SVVYECGPSCHCPPS-CRNRVSQ 530
KC C Q +N P S+ + K + +YEC C C C+NRV Q
Sbjct: 304 -KCACLQLTARNAKTSPLSSDKITTGYKYKRLQRQIPTGIYECSLLCKCNRQLCQNRVVQ 362
Query: 531 GGLKLRLEVFRTKGKGWGLRSWDPIRAGTFICEYAGEVIDNARVEELSG-------ENED 583
G ++RL+VF+T+ KGWG+R D I GTF+C Y+G ++ A E+ G EN
Sbjct: 363 HGPQVRLQVFKTEQKGWGVRCLDDIDRGTFVCIYSGRLLSRANTEKSYGIDENGRDENTM 422
Query: 584 DYIFDSTRIYQQLEVFSSDVEAPKIPSPLYI---TARNEGNVARFMNH 628
IF R +LEV SD E +P L TA+ E +F N+
Sbjct: 423 KNIFSKKR---KLEVACSDCEVEVLPLGLETHPRTAKTEKCPPKFSNN 467
Score = 63.5 bits (153), Expect = 2e-09
Identities = 35/79 (44%), Positives = 45/79 (56%), Gaps = 1/79 (1%)
Query: 614 ITARNEGNVARFMNHSCTPNVLWRPVVRENKNEADLHVAFYAIRHIPPMMELTYDYGIVL 673
+ A EGNV RF+NHSC PN+L + V E N VAF+ R++ ELT+DYG
Sbjct: 638 LDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRNFPLVAFFTNRYVKARTELTWDYGYEA 697
Query: 674 PLKVGQKKKKCLCGSVKCR 692
V +K+ C CG KCR
Sbjct: 698 G-TVPEKEIFCQCGVNKCR 715
>SETB_MOUSE (O88974) Histone-lysine N-methyltransferase, H3 lysine-9
specific 4 (EC 2.1.1.43) (Histone H3-K9
methyltransferase 4) (H3-K9-HMTase 4) (SET domain
bifurcated 1) (ERG-associated protein with SET domain)
(ESET)
Length = 1307
Score = 99.8 bits (247), Expect = 2e-20
Identities = 69/213 (32%), Positives = 103/213 (47%), Gaps = 19/213 (8%)
Query: 427 DLTSGAEKLPVCLVNDVDNEKGP--AYFTYSPTLKNLNRLAPVESSEGCTCNGGCQPGSH 484
D+T G E +P+ VN++D P AY K + E GC C GC+ S
Sbjct: 698 DITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFINTGPEFLVGCDCKDGCRDKS- 756
Query: 485 KCGCTQKN--------GGYLP----YSAAGLLADLKSVVYECGPSCHCPPS-CRNRVSQG 531
KC C Q GG + Y L L + VYEC C+C P+ C NR+ Q
Sbjct: 757 KCACHQLTIQATACTPGGQVNPNSGYQYKRLEECLPTGVYECNKRCNCDPNMCTNRLVQH 816
Query: 532 GLKLRLEVFRTKGKGWGLRSWDPIRAGTFICEYAGEVIDNARVEELSGENEDDYIFDSTR 591
GL++RL++F+T+ KGWG+R D I G+F+C YAG+++ + ++ E D+Y +
Sbjct: 817 GLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDDFADKEGLEMGDEYFANLDH 876
Query: 592 IYQQ---LEVFSSDVEAPKIPSPLYITARNEGN 621
I E + SDV S + + + +GN
Sbjct: 877 IESVENFKEGYESDVPTSSDSSGVDMKDQEDGN 909
Score = 59.7 bits (143), Expect = 3e-08
Identities = 31/80 (38%), Positives = 48/80 (59%), Gaps = 1/80 (1%)
Query: 614 ITARNEGNVARFMNHSCTPNVLWRPVVRENKNEADLHVAFYAIRHIPPMMELTYDYGIVL 673
I A+ EGN+ R++NHSC+PN+ + V + + VAF+A + I ELT+DY +
Sbjct: 1226 IDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGTELTWDYNYEV 1285
Query: 674 PLKVGQKKKKCLCGSVKCRG 693
V K+ C CG+++CRG
Sbjct: 1286 G-SVEGKELLCCCGAIECRG 1304
>SETB_HUMAN (Q15047) Histone-lysine N-methyltransferase, H3 lysine-9
specific 4 (EC 2.1.1.43) (Histone H3-K9
methyltransferase 4) (H3-K9-HMTase 4) (SET domain
bifurcated 1) (ERG-associated protein with SET domain)
(ESET)
Length = 1291
Score = 98.2 bits (243), Expect = 6e-20
Identities = 65/194 (33%), Positives = 96/194 (48%), Gaps = 17/194 (8%)
Query: 427 DLTSGAEKLPVCLVNDVDNEKGP--AYFTYSPTLKNLNRLAPVESSEGCTCNGGCQPGSH 484
D+T G E +P+ VN++D P AY K + E GC C GC+ S
Sbjct: 681 DITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFINTGPEFLVGCDCKDGCRDKS- 739
Query: 485 KCGCTQKN--------GGYLP----YSAAGLLADLKSVVYECGPSCHCPPS-CRNRVSQG 531
KC C Q GG + Y L L + VYEC C C P+ C NR+ Q
Sbjct: 740 KCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVYECNKRCKCDPNMCTNRLVQH 799
Query: 532 GLKLRLEVFRTKGKGWGLRSWDPIRAGTFICEYAGEVIDNARVEELSGENEDDYIFDSTR 591
GL++RL++F+T+ KGWG+R D I G+F+C YAG+++ + ++ E D+Y +
Sbjct: 800 GLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDDFADKEGLEMGDEYFANLDH 859
Query: 592 IYQQLEVFSSDVEA 605
I + +E F E+
Sbjct: 860 I-ESVENFKEGYES 872
Score = 59.7 bits (143), Expect = 3e-08
Identities = 31/80 (38%), Positives = 48/80 (59%), Gaps = 1/80 (1%)
Query: 614 ITARNEGNVARFMNHSCTPNVLWRPVVRENKNEADLHVAFYAIRHIPPMMELTYDYGIVL 673
I A+ EGN+ R++NHSC+PN+ + V + + VAF+A + I ELT+DY +
Sbjct: 1210 IDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGTELTWDYNYEV 1269
Query: 674 PLKVGQKKKKCLCGSVKCRG 693
V K+ C CG+++CRG
Sbjct: 1270 G-SVEGKELLCCCGAIECRG 1288
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.317 0.136 0.413
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 90,910,378
Number of Sequences: 164201
Number of extensions: 4318178
Number of successful extensions: 11333
Number of sequences better than 10.0: 100
Number of HSP's better than 10.0 without gapping: 42
Number of HSP's successfully gapped in prelim test: 59
Number of HSP's that attempted gapping in prelim test: 11009
Number of HSP's gapped (non-prelim): 222
length of query: 696
length of database: 59,974,054
effective HSP length: 117
effective length of query: 579
effective length of database: 40,762,537
effective search space: 23601508923
effective search space used: 23601508923
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 69 (31.2 bits)
Lotus: description of TM0098b.1