BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= TM0057b.10
(306 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
C190_DROME (Q9VJE5) Restin homolog (Cytoplasmic linker protein 1... 57 7e-08
MYH9_CHICK (P14105) Myosin heavy chain, nonmuscle (Cellular myos... 55 3e-07
TPR_HUMAN (P12270) Nucleoprotein TPR 54 5e-07
RA50_PYRFU (P58301) DNA double-strand break repair rad50 ATPase 53 8e-07
LPA1_HUMAN (Q13136) Liprin-alpha 1 (Protein tyrosine phosphatase... 53 8e-07
GOA4_MOUSE (Q91VW5) Golgi autoantigen, golgin subfamily A member... 53 8e-07
CENE_HUMAN (Q02224) Centromeric protein E (CENP-E protein) 52 2e-06
SMI1_YARLI (Q6CDX0) KNR4/SMI1 homolog 52 2e-06
MYHB_HUMAN (P35749) Myosin heavy chain, smooth muscle isoform (S... 50 5e-06
TPM1_PIG (P42639) Tropomyosin 1 alpha chain (Alpha-tropomyosin) 50 7e-06
MYH9_RAT (Q62812) Myosin heavy chain, nonmuscle type A (Cellular... 50 7e-06
REST_HUMAN (P30622) Restin (Cytoplasmic linker protein-170 alpha... 50 9e-06
PLE1_RAT (P30427) Plectin 1 (PLTN) (PCN) 50 9e-06
PLE1_HUMAN (Q15149) Plectin 1 (PLTN) (PCN) (Hemidesmosomal prote... 50 9e-06
MYHB_RAT (Q63862) Myosin heavy chain, smooth muscle isoform (SMM... 50 9e-06
GOB1_HUMAN (Q14789) Golgi autoantigen, golgin subfamily B member... 50 9e-06
TPM1_RAT (P04692) Tropomyosin 1 alpha chain (Alpha-tropomyosin) 49 1e-05
TPM1_RABIT (P58772) Tropomyosin 1 alpha chain (Alpha-tropomyosin) 49 1e-05
TPM1_MOUSE (P58771) Tropomyosin 1 alpha chain (Alpha-tropomyosin) 49 1e-05
MYHB_RABIT (P35748) Myosin heavy chain, smooth muscle isoform (S... 49 1e-05
>C190_DROME (Q9VJE5) Restin homolog (Cytoplasmic linker protein 190)
(Microtubule binding protein 190) (d-CLIP-190)
Length = 1690
Score = 56.6 bits (135), Expect = 7e-08
Identities = 44/195 (22%), Positives = 89/195 (45%), Gaps = 11/195 (5%)
Query: 27 MKETLLVKDEELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASAAHTIDEQWRNACEE 86
++E L + Q ++ +T + +I + L E ++ + ++E+ R +
Sbjct: 1194 LEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSI 1253
Query: 87 IESLK---KDSEKQLELSAQKLKEYEVKIISLSKEKEQLSKQREAATQEANMWRSELGKA 143
IE+ +S QLE LKE + +++ K+++QL +EA EL +
Sbjct: 1254 IEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQ-------EEAAKLSGELQQV 1306
Query: 144 RESGVILEGALARAEEKVRVAEANAEAKIKEAVQGESAAVSEKQELLAYVDKLKAQLQRQ 203
+E+ ++ +L + EE V+V E +A + + + A E QELL + + LQ +
Sbjct: 1307 QEANGDIKDSLVKVEELVKVLEEKLQAATSQ-LDAQQATNKELQELLVKSQENEGNLQGE 1365
Query: 204 HIDSTEVFEKTESCS 218
+ TE ++ E +
Sbjct: 1366 SLAVTEKLQQLEQAN 1380
Score = 44.7 bits (104), Expect = 3e-04
Identities = 61/276 (22%), Positives = 123/276 (44%), Gaps = 25/276 (9%)
Query: 34 KDEELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASAAHTIDEQWR---NACEEIESL 90
K +E + ++R RD IR++ ++L E + + +D+ R EE +L
Sbjct: 613 KTDECEILQTEVRMRDEQIRELNQQLDEVTTQLNVQKADSSALDDMLRLQKEGTEEKSTL 672
Query: 91 KKDSEKQLELSAQKLKEYEVKIISLSKEKEQLSKQ----REAATQE---ANMWRSELGKA 143
+ +EK+L S KE K ++ +KEQL KQ ++ A QE M + + +
Sbjct: 673 LEKTEKELVQS----KEQAAKTLN---DKEQLEKQISDLKQLAEQEKLVREMTENAINQI 725
Query: 144 RESGVILEGALARAE---EKVRVAEANAEAKIKEAVQGESAAVSEKQELLAYVDKLKAQL 200
+ +E LA + E + ++ +E ++E + E E + KL+ QL
Sbjct: 726 QLEKESIEQQLALKQNELEDFQKKQSESEVHLQEIKAQNTQKDFELVESGESLKKLQQQL 785
Query: 201 QRQHIDSTEVFEKTESCSDTKHVDLTEENVDKACLSVSRSVPDPAAAECVVQMPTDQVII 260
+++ + ++ E K + E+ + L S+S +A + VVQ+ +Q+
Sbjct: 786 EQKTLGHEKLQAALEELKKEKETIIKEKEQELQQLQ-SKSAESESALK-VVQVQLEQLQQ 843
Query: 261 QPVGDNEWSDIQATEARVAD-VREVASESEVSSLDI 295
Q E + T A++ D + ++ S++E + ++
Sbjct: 844 QAAASGE--EGSKTVAKLHDEISQLKSQAEETQSEL 877
Score = 42.4 bits (98), Expect = 0.001
Identities = 44/206 (21%), Positives = 94/206 (45%), Gaps = 18/206 (8%)
Query: 34 KDEELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASAAHTIDEQWR--------NACE 85
K +L+ ++ ++ I +LS E +A S + I E + E
Sbjct: 1109 KIADLKTLVEAIQVANANISATNAELSTVLEVLQAEKSETNHIFELFEMEADMNSERLIE 1168
Query: 86 EIESLK---KDSEKQLELSAQKLKEYEVKIISLSKEKEQLSKQREAATQEANMWRSELGK 142
++ +K K++ QL+ +K +E E K+ + +++L ++ + + ++ + L +
Sbjct: 1169 KVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSKEKLTEIQQSLQE 1228
Query: 143 ARESGVILEGALARAEEKVRVAEANAEA---KIKEA---VQGESAAVSEKQELLAYVDKL 196
++S E + EEKVR + + EA K+ E+ ++ +++ + E Q+ L K
Sbjct: 1229 LQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLKETQDQLLESQKK 1288
Query: 197 KAQLQRQHID-STEVFEKTESCSDTK 221
+ QLQ + S E+ + E+ D K
Sbjct: 1289 EKQLQEEAAKLSGELQQVQEANGDIK 1314
Score = 42.4 bits (98), Expect = 0.001
Identities = 41/236 (17%), Positives = 94/236 (39%), Gaps = 29/236 (12%)
Query: 6 RNTLGMMTNKTTDGPMDDLTIMKETLLV-KDEELQNFARDLRTRDSTIRDIAEKLSETAE 64
+ TLG ++ +++L KET++ K++ELQ +S ++ + +L + +
Sbjct: 787 QKTLG---HEKLQAALEELKKEKETIIKEKEQELQQLQSKSAESESALKVVQVQLEQLQQ 843
Query: 65 AAEAAASAAHTIDEQWRNACEEIESLKKDSEKQLELSAQKLKEYEVKIISLSKEKEQLSK 124
A A+ + + +++S ++++ +L+ + L E SK
Sbjct: 844 QAAASGEEGSKTVAKLHDEISQLKSQAEETQSELKSTQSNL--------------EAKSK 889
Query: 125 QREAATQEANMWRSELGKARESGVILEGALARAEEKVRVAEANAEAKIKEAVQGESAAVS 184
Q EAA + G E L+ + + + + E+K K+ +A
Sbjct: 890 QLEAANGSLEEEAKKSGHLLEQITKLKSEVGETQAALSSCHTDVESKTKQLEAANAA--- 946
Query: 185 EKQELLAYVDKLKAQLQRQHIDSTEVFEKTESCSDTKHVDLTEENVDKACLSVSRS 240
++K+ + +++++ +K + +DT H +L E + L S
Sbjct: 947 --------LEKVNKEYAESRAEASDLQDKVKEITDTLHAELQAERSSSSALHTKLS 994
>MYH9_CHICK (P14105) Myosin heavy chain, nonmuscle (Cellular myosin
heavy chain) (NMMHC)
Length = 1959
Score = 54.7 bits (130), Expect = 3e-07
Identities = 50/201 (24%), Positives = 97/201 (47%), Gaps = 14/201 (6%)
Query: 27 MKETLLVKDEELQ-------NFARDLRTRDSTIRDIAEKLSETAEAAEAAASAAHTIDEQ 79
+K L K+EELQ A IR++ +++E E E+ ++ + ++Q
Sbjct: 1074 LKIQLSKKEEELQAALARVEEEAAQKNMALKKIRELESQITELQEDLESERASRNKAEKQ 1133
Query: 80 WRNACEEIESLKKDSEKQLELSA--QKLK-EYEVKIISLSKEKEQLSKQREAATQEANMW 136
R+ EE+E+LK + E L+ +A Q+L+ + E ++ L K E +K EA QE
Sbjct: 1134 KRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVTVLKKTLEDEAKTHEAQIQEMRQK 1193
Query: 137 RS----ELGKARESGVILEGALARAEEKVRVAEANAEAKIKEAVQGESAAVSEKQELLAY 192
S EL + E ++ L +A++ + A ++K +QG+ A +++++ A
Sbjct: 1194 HSQAIEELAEQLEQTKRVKANLEKAKQALESERAELSNEVKVLLQGKGDAEHKRKKVDAQ 1253
Query: 193 VDKLKAQLQRQHIDSTEVFEK 213
+ +L+ + TE+ E+
Sbjct: 1254 LQELQVKFTEGERVKTELAER 1274
Score = 42.4 bits (98), Expect = 0.001
Identities = 35/187 (18%), Positives = 83/187 (43%), Gaps = 16/187 (8%)
Query: 52 IRDIAEKLSETAEAAEAAASAAHTIDEQWRNACEEIESLKKDSEK---QLELSAQKLKEY 108
++D+ + + + A + Q ++ E+E + E+ Q + + +KLK
Sbjct: 1619 LKDLESHIDTANKNRDEAIKHVRKLQAQMKDYMRELEDTRTSREEILAQAKENEKKLKSM 1678
Query: 109 EVKIISLSKEKEQLSKQREAATQEANMWRSELGKARESGVI-------LEGALARAEEKV 161
E ++I L +E + + A QE + E+ + G + LE +A+ EE++
Sbjct: 1679 EAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALAMEEKRRLEARIAQLEEEL 1738
Query: 162 RVAEANAEA---KIKEA---VQGESAAVSEKQELLAYVDKLKAQLQRQHIDSTEVFEKTE 215
+ N E ++K+A + +A ++ ++ + + Q++RQ+ + ++ E
Sbjct: 1739 EEEQGNTEIINDRLKKANLQIDQMNADLNAERSNAQKNENARQQMERQNKELKLKLQEME 1798
Query: 216 SCSDTKH 222
S +K+
Sbjct: 1799 SAVKSKY 1805
Score = 33.1 bits (74), Expect = 0.88
Identities = 56/290 (19%), Positives = 112/290 (38%), Gaps = 45/290 (15%)
Query: 36 EELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASAAHTIDEQWRNACE---------- 85
EE + R +++ +A L E E + +++Q+R E
Sbjct: 1462 EERDRAEAEAREKETKALSLARALEEAIEQK----AELERVNKQFRTEMEDLMSSKDDVG 1517
Query: 86 ----EIESLKKDSEKQLELSAQKLKEYEVKIISLSKEKEQLSKQREAATQEANMWRSELG 141
E+E K+ E+Q+E +L+E E ++ + K +L ++A +A R LG
Sbjct: 1518 KSVHELEKAKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNQQA--MKAQFDRDLLG 1575
Query: 142 K--------------ARESGVILEGALARAEEKVRV-AEANAEAKIKEAVQGESAAVSEK 186
+ RE V LE R + + V A E +K+ A +
Sbjct: 1576 RDEQNEEKRKQLIRQVREMEVELED--ERKQRSIAVAARKKLELDLKDLESHIDTANKNR 1633
Query: 187 QELLAYVDKLKAQLQ--RQHIDSTEVFEKTESCSDTKHVDLTEENVDKACLSVSRSVPDP 244
E + +V KL+AQ++ + ++ T + E + K + ++++ + + +
Sbjct: 1634 DEAIKHVRKLQAQMKDYMRELEDTRT-SREEILAQAKENEKKLKSMEAEMIQLQEELAAA 1692
Query: 245 AAAECVVQMPTDQVIIQPV-----GDNEWSDIQATEARVADVREVASESE 289
A+ Q D++ + G + + EAR+A + E E +
Sbjct: 1693 ERAKRQAQQERDELADEIANSSGKGALAMEEKRRLEARIAQLEEELEEEQ 1742
Score = 32.7 bits (73), Expect = 1.2
Identities = 47/205 (22%), Positives = 92/205 (43%), Gaps = 16/205 (7%)
Query: 14 NKTTDGPMDDLTIMKETLLVKDEELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASAA 73
NK M+DL K+ + EL+ R L + ++ E+L + +A E A
Sbjct: 1499 NKQFRTEMEDLMSSKDDVGKSVHELEKAKRALEQQVEEMKTQLEELEDELQATEDAKLRL 1558
Query: 74 HTIDEQWRNACEEIESLKKD--SEKQLELSAQKLKEYEVKI----------ISLSKEKEQ 121
+++Q A + + L +D +E++ + ++++E EV++ ++ K+ E
Sbjct: 1559 E-VNQQAMKAQFDRDLLGRDEQNEEKRKQLIRQVREMEVELEDERKQRSIAVAARKKLEL 1617
Query: 122 LSKQREAATQEANMWRSELGK-ARESGVILEGALARAEE-KVRVAEANAEAKIKE-AVQG 178
K E+ AN R E K R+ ++ + E+ + E A+AK E ++
Sbjct: 1618 DLKDLESHIDTANKNRDEAIKHVRKLQAQMKDYMRELEDTRTSREEILAQAKENEKKLKS 1677
Query: 179 ESAAVSEKQELLAYVDKLKAQLQRQ 203
A + + QE LA ++ K Q Q++
Sbjct: 1678 MEAEMIQLQEELAAAERAKRQAQQE 1702
>TPR_HUMAN (P12270) Nucleoprotein TPR
Length = 2349
Score = 53.9 bits (128), Expect = 5e-07
Identities = 46/193 (23%), Positives = 89/193 (45%), Gaps = 14/193 (7%)
Query: 36 EELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASAAHTIDEQWRNACEEIESLKKDSE 95
E++ + LR + + D+ E+L + E + +++E + E ++K+ E
Sbjct: 932 EDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIE 991
Query: 96 KQLELSAQKLKEYEVKIISLSKEKEQLSKQREAATQEANMWRSELGKARES-GVILEGAL 154
+L+ SA+ + E K++ + KEK++L + A + SEL K S ++ AL
Sbjct: 992 VRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEAL 1051
Query: 155 ARAEEKV---RVAEANAEAKIKEAVQGESAAVSEKQELLAYVDKLKAQLQ--------RQ 203
RA + + A + + + K AV+ ++ E A V+ L+A + RQ
Sbjct: 1052 QRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQ 1111
Query: 204 HIDSTEVFEKTES 216
H++ T +K ES
Sbjct: 1112 HLEETT--QKAES 1122
Score = 40.0 bits (92), Expect = 0.007
Identities = 61/270 (22%), Positives = 107/270 (39%), Gaps = 36/270 (13%)
Query: 36 EELQNFARDLR---TRDSTIRDIAEK----LSETAEAAEAAASAAHTIDEQWRNACEEIE 88
E+LQ DLR T+ ST D A K L + E ++ H +++ ++ E
Sbjct: 698 EKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQE 757
Query: 89 SLKKDSEKQLELSAQKLKEYEVKIISLSKEKE-------QLSKQREAATQEANMWRSELG 141
+ + L + +KL EV+ +L KEKE +LS+QRE+ E L
Sbjct: 758 QIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLT 817
Query: 142 KARESGVILEGALARAEEKVRVAEANAEAKIKEAVQGESAAVSEKQELLAYVDKLKAQLQ 201
+ ILE + ++++ E +I + V ++ L +D +
Sbjct: 818 NLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTK 877
Query: 202 RQ-------HIDSTEVFEKTESCSDTKHVDLTEENVDKACLSVSRS-VPDPAAAECVVQM 253
RQ H+++ E+ + + T L+ V A S R+ P+ E V
Sbjct: 878 RQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDV--- 934
Query: 254 PTDQVIIQPVGDNEWSDIQATEARVADVRE 283
D+ S ++ TE +V D++E
Sbjct: 935 -----------DDLVSQLRQTEEQVNDLKE 953
Score = 36.6 bits (83), Expect = 0.080
Identities = 51/286 (17%), Positives = 116/286 (39%), Gaps = 23/286 (8%)
Query: 11 MMTNKTTDGPMDDLTIMKETLLVKDEELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAA 70
M +T + M+ +++E +++LQ +R + I + E +E +E +
Sbjct: 1263 MKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQ 1322
Query: 71 SAAHTIDE---QWRNACEEIESLKKDSEKQLELSAQKLKEYEVKIISLSKEKEQLSKQRE 127
+ ++E +W+ + + S +KD + + EY L EKE +K+ +
Sbjct: 1323 AEKKLLEEDVKRWKARNQHLVSQQKDPDTE---------EYR----KLLSEKEVHTKRIQ 1369
Query: 128 AATQEANMWRSELGKARESGVILEGALARAEEKVRVAEANAEAKIKEAVQGESAAVSEKQ 187
T+E ++E+ ++ S + + +E + E I++ + + + EK
Sbjct: 1370 QLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKET-IQKDLDAKIIDIQEKV 1428
Query: 188 ELLAYVDKLKAQLQRQHIDSTEVFEKTESCSDTKHVDLTEENVDKACLSVSRSVPDPAAA 247
+ + V K+ + + Q+ + +K S D E++V + + + A
Sbjct: 1429 KTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAET 1488
Query: 248 ECVVQMPTDQVIIQPVGDNEWSDIQATEARVADVREVASESEVSSL 293
+ + + + + + E TEAR + V +SE+S L
Sbjct: 1489 KSKSLESQVENLQKTLSEKE------TEARNLQEQTVQLQSELSRL 1528
Score = 34.7 bits (78), Expect = 0.30
Identities = 31/156 (19%), Positives = 64/156 (40%), Gaps = 10/156 (6%)
Query: 37 ELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASAAHTIDEQWRNACEEI---ESLKKD 93
+++ R +T+ ++ +K+ ET+ + H ++ + E + E+ K
Sbjct: 1433 QVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKS 1492
Query: 94 SEKQLELSAQKLKEYEVKIISLSKEKEQLSKQREAATQEANMWRSELGKARESGVILEGA 153
E Q+E + L E E + +L ++ QL + Q+ ++ + R+
Sbjct: 1493 LESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQ------- 1545
Query: 154 LARAEEKVRVAEANAEAKIKEAVQGESAAVSEKQEL 189
+ EEK R A A++KI + E +EL
Sbjct: 1546 ITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEEL 1581
Score = 30.4 bits (67), Expect = 5.7
Identities = 35/192 (18%), Positives = 86/192 (44%), Gaps = 7/192 (3%)
Query: 44 DLRTRDSTIRDIAEKLSETAEAAEAAASAAHTIDEQWR--NACEEIESLKKDSEKQLELS 101
+L+ ++ + +L ET E E +++ + Q + +A E+E L+K + Q++L
Sbjct: 545 ELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLV 604
Query: 102 AQKLKEYEVKIISLSKEKEQLSKQREAATQEANMWRSELGKARESGVILEGALARAEEKV 161
+++ ++ I LS+ ++ + ++ S + S + A E
Sbjct: 605 DSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSL-ASTPKRPSTSQTVSTPAPVPVIEST 663
Query: 162 RVAEANAEAK-IKEAVQGESAAVSEKQELL-AYVDKLKAQLQRQHIDSTEVFEKTESCSD 219
EA A K ++E + +E +++ ++KL+ Q+ +T++ + + S
Sbjct: 664 EAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFAS- 722
Query: 220 TKHVDLTEENVD 231
K ++ ++NV+
Sbjct: 723 -KRYEMLQDNVE 733
Score = 29.6 bits (65), Expect = 9.8
Identities = 34/155 (21%), Positives = 72/155 (45%), Gaps = 16/155 (10%)
Query: 24 LTIMKETLLVKDEELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASAAHTIDEQWRNA 83
L+ +E L+ + E Q+ +L ++ ++ + EK E E A I Q+
Sbjct: 61 LSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKEL----EIAQDRNIAIQSQFTRT 116
Query: 84 CEEIESLKKDSEKQLELSAQKLKEYEVKIISLSKEKEQLSKQREAATQEANMWRSELGKA 143
EE+E+ K+D + E +Q+L EY L+++ ++L+++ + + + +L +
Sbjct: 117 KEELEAEKRDLIRTNERLSQEL-EY------LTEDVKRLNEKLKESNTTKGELQLKLDEL 169
Query: 144 RESGVILEGALARAEEKVRVAEA-----NAEAKIK 173
+ S V ++ R E++ + + N E K K
Sbjct: 170 QASDVSVKYREKRLEQEKELLHSQNTWLNTELKTK 204
>RA50_PYRFU (P58301) DNA double-strand break repair rad50 ATPase
Length = 882
Score = 53.1 bits (126), Expect = 8e-07
Identities = 49/204 (24%), Positives = 97/204 (47%), Gaps = 8/204 (3%)
Query: 37 ELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASAAH---TIDEQWRNACEEIESLKKD 93
E + +LRT + IR +AE L + A + A+ H ++++ + ++ES
Sbjct: 529 EYEKLLEELRTLEGRIRGLAEDLKKLAPLEKKLAALIHKKQELEKELKELNTKLESFGFK 588
Query: 94 SEKQLELSAQKLKEYEVKIISLSKEKEQLS-KQREAATQEANMWRS--ELGKARESGVIL 150
S + L+ ++L+E + ++L K++L QRE A + + S EL + +
Sbjct: 589 SVEDLDSKLRELEEIYKRYLTLLNSKKELEITQREIAKAKETLEMSFEELAEVEADIERI 648
Query: 151 EGALARAEEKVRVAEANAEAKIKEAVQGESAAV-SEKQELLAYVDKLKAQLQRQHIDSTE 209
E L++ ++K E + + KE ++ E A + ++K+EL D +K+ L++ +
Sbjct: 649 EKKLSQLKQKYNEEEYKKKREEKEELEKELARLEAQKKELEKRRDTIKSTLEKLKAEKEN 708
Query: 210 VFEKTESCSD-TKHVDLTEENVDK 232
+ D K D TEE ++K
Sbjct: 709 RERVKKEIKDLEKAKDFTEELIEK 732
Score = 31.2 bits (69), Expect = 3.4
Identities = 29/131 (22%), Positives = 55/131 (41%), Gaps = 9/131 (6%)
Query: 28 KETLLVKDEELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASAAHTIDEQWRNACEEI 87
KETL + EEL D+ + + + +K +E + E+ +
Sbjct: 628 KETLEMSFEELAEVEADIERIEKKLSQLKQKYNEEEYKKKREEK------EELEKELARL 681
Query: 88 ESLKKDSEKQ---LELSAQKLKEYEVKIISLSKEKEQLSKQREAATQEANMWRSELGKAR 144
E+ KK+ EK+ ++ + +KLK + + KE + L K ++ + + AR
Sbjct: 682 EAQKKELEKRRDTIKSTLEKLKAEKENRERVKKEIKDLEKAKDFTEELIEKVKKYKALAR 741
Query: 145 ESGVILEGALA 155
E+ + G LA
Sbjct: 742 EAALSKIGELA 752
>LPA1_HUMAN (Q13136) Liprin-alpha 1 (Protein tyrosine phosphatase
receptor type f polypeptide-interacting protein alpha 1)
(PTPRF-interacting protein alpha 1) (LAR-interacting
protein 1) (LIP.1)
Length = 1202
Score = 53.1 bits (126), Expect = 8e-07
Identities = 53/245 (21%), Positives = 111/245 (44%), Gaps = 34/245 (13%)
Query: 2 QISLRNTLGMMTNKTTDGPMDDLTIMKETLLVKDEELQNFARDLRTRDSTIRDIAEKLSE 61
Q ++ L +++ T+ +DL ++ L+ +E RD+R + D+ E+++
Sbjct: 266 QSQMKERLASLSSHVTELE-EDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDMEERITT 324
Query: 62 TAE---AAEAAASAAHTIDEQWRNACEEIESLKKDSE-------KQLELSAQKLK----- 106
+ AA+ A++ H ++++ N +S+ + +E ++LEL+ QKL+
Sbjct: 325 LEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQQTLRK 384
Query: 107 ---------EYEVKIISLSKEK------EQLSKQREAATQEANMWRSELGKARESGVILE 151
E ++ +LSK + E+ +Q EA +E N EL +AR+ + E
Sbjct: 385 AETLPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQLEEKN---QELQRARQREKMNE 441
Query: 152 GALARAEEKVRVAEANAEAKIKEAVQGESAAVSEKQELLAYVDKLKAQLQRQHIDSTEVF 211
R + V + + +++ ++ AA+ +K LL V+ K QL+ D ++
Sbjct: 442 EHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLLREVESAKKQLEETQHDKDQLV 501
Query: 212 EKTES 216
E+
Sbjct: 502 LNIEA 506
>GOA4_MOUSE (Q91VW5) Golgi autoantigen, golgin subfamily A member 4
(tGolgin-1)
Length = 2238
Score = 53.1 bits (126), Expect = 8e-07
Identities = 51/223 (22%), Positives = 97/223 (42%), Gaps = 23/223 (10%)
Query: 29 ETLLVKDEELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASAAHT-IDEQWRNACEEI 87
E L K EL++ + +L +AE+LS A+ A ++EQ R+ E+
Sbjct: 697 EKLDKKQMELESVSSELSEALRARDQLAEELSVLRGDADKMKQALEAELEEQRRHHQREV 756
Query: 88 ESLKKDSEKQLELSAQKLKEYEVKIISLSKEKEQLSKQREAATQEA-------------- 133
S+ + E + + + LK+ ++ +L E+++ ++R+A Q+
Sbjct: 757 GSISEQQELTVRRAEKALKDELSRLGALLDERDEHLRERQARVQDLEAHLQKSAGELQQA 816
Query: 134 ----NMWRSELGKARESGVILEGALARAEEKVRVAEANAEAKIKEAVQGESAAVSEKQEL 189
++ SE ARE E LA+ ++KV E K+ V+ E + K+ +
Sbjct: 817 LAKLDLLHSEQSAAREQAGAYEEQLAQMQQKVLDLETEKSLLTKQVVEME----THKKHV 872
Query: 190 LAYVDKLKAQLQRQHIDSTEVFEKTESCSDTKHVDLTEENVDK 232
+D +AQ+Q+ +E+ EK S + + L V+K
Sbjct: 873 CEELDAQRAQVQQLERQRSELEEKVRSLAQLQDSQLKNSTVEK 915
Score = 48.1 bits (113), Expect = 3e-05
Identities = 62/277 (22%), Positives = 112/277 (40%), Gaps = 61/277 (22%)
Query: 23 DLTIMKETLLVKDEELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASAAHTIDEQWRN 82
++ I+K+TL K+E + + T+ EK+ + A+ + E +
Sbjct: 939 EIEILKQTLSSKEESISILHEEYETKFKNQEKRMEKIKQKAK----------EMQETKKK 988
Query: 83 ACEEIESLKKDSEKQLELSAQKLKEYEVKII------------SLSKEKEQLSKQREAAT 130
++ LKK+ E + +QK K++ +I+ ++S+ +E +Q E+ T
Sbjct: 989 LLDQEAKLKKELENTVLELSQKEKQFNAQILEMAQANSAGISDTVSRLEENQRQQIESLT 1048
Query: 131 --------QEANMWRSELG--------KARESGVILEGALARAEEKVRVAEANAE----- 169
W +L K E E L +KVR+ ++ E
Sbjct: 1049 GAHQRKLDDVIEAWEKKLSQQAAELRDKHAEQMEEKEQGLGELRQKVRIVQSEKEELTKE 1108
Query: 170 -AKIKEAVQGESAAVS-------EKQELLAYVDKLKAQLQRQHIDSTEVFEKTESCSDTK 221
A++KEAV G+ A++ +K ++ + + ++QLQ Q E E CS ++
Sbjct: 1109 VARLKEAVSGQDVALAGLQGQLEQKSAVIVSLSERESQLQSQ----VEKLEADLGCSLSE 1164
Query: 222 HVDLTEE------NVDKACLSVSRSVPDPAAAECVVQ 252
+ L EE DK+ L VS AAE +Q
Sbjct: 1165 KLSLQEELAELKLLADKSQLRVSELTGQVQAAEKELQ 1201
Score = 42.4 bits (98), Expect = 0.001
Identities = 38/167 (22%), Positives = 78/167 (45%), Gaps = 20/167 (11%)
Query: 24 LTIMKETLLVKDEELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASAAHTIDEQWRNA 83
+T +K+ L + +L + S I ++++LS+ E++ S + +
Sbjct: 1356 ITQLKKELAENINAVTLLREELSEKKSEIASLSKQLSDLGAQLESSISPS--------DK 1407
Query: 84 CEEIESLKKDSEKQ-LELSAQKLKEYEVKIISLSKEKEQLSKQREAATQEANMWRSELGK 142
E I +L K E+Q L+L AQ L+E +K+ +LSKEK +Q + + + + W+ +
Sbjct: 1408 AEAISALSKQHEEQELQLQAQ-LQELSLKVDALSKEKMSALEQVDHWSNKFSEWKKK--- 1463
Query: 143 ARESGVILEGALARAEEKVRVAEANAEAKIKEAVQGESAAVSEKQEL 189
+ LA+ + ++ +A + K +A + E K++L
Sbjct: 1464 -------AQSRLAQHQSTIKDLQAQLDVKATDAREKEEQICLLKEDL 1503
Score = 36.6 bits (83), Expect = 0.080
Identities = 49/202 (24%), Positives = 84/202 (41%), Gaps = 20/202 (9%)
Query: 37 ELQNFARDL-RTRDSTIRDIAEKLSETAEAAEAAASAAHTIDEQWRNACEEIESLKKDSE 95
EL+ R L + +DS +++ E +A ++ + I + +EIE LK+
Sbjct: 892 ELEEKVRSLAQLQDSQLKN---STVEKEQARQSLMEKENIILQMREEQAKEIEILKQTLS 948
Query: 96 KQLELSAQKLKEYEVKIISLSKEKEQLSKQREAATQEANMWRSELGKARESGVILEGALA 155
+ E + +EYE K + K E++ KQ+ QE + L + + LE +
Sbjct: 949 SKEESISILHEEYETKFKNQEKRMEKI-KQKAKEMQETK--KKLLDQEAKLKKELENTVL 1005
Query: 156 RAEEKVRVAEANAEAKIKEAVQGESAAVSE-----KQELLAYVDKLKAQLQRQHIDSTEV 210
+K E A+I E Q SA +S+ ++ ++ L QR+ D E
Sbjct: 1006 ELSQK----EKQFNAQILEMAQANSAGISDTVSRLEENQRQQIESLTGAHQRKLDDVIEA 1061
Query: 211 FEKTESCSDT----KHVDLTEE 228
+EK S KH + EE
Sbjct: 1062 WEKKLSQQAAELRDKHAEQMEE 1083
Score = 36.6 bits (83), Expect = 0.080
Identities = 50/195 (25%), Positives = 85/195 (42%), Gaps = 25/195 (12%)
Query: 28 KETLLVKDEELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASAAHTIDE---QWRNAC 84
K L K EL +RD D+ + +++ TA EA + E Q
Sbjct: 1240 KALLEAKTNELVCTSRD--KADAILARLSQCQRHTATVGEALLRRMGQVSELEAQLTQLT 1297
Query: 85 EEIESLKKDSEK---QLELSAQKLKEYEVKIISLSKEKEQL----SKQREAATQEAN--- 134
EE +LK ++ QLE +++K + I L EKE L +QR+AA+++ +
Sbjct: 1298 EEQRTLKSSFQQVTNQLEEKEKQIKTMKADIEGLLTEKEALQQEGGQQRQAASEKESCIT 1357
Query: 135 MWRSELGKARESGVILEGALARAEEKVRVAEANAEAKIKEAVQGESAAVSEKQELLAYVD 194
+ EL + + +L L +E+K +A + + A S + S+K E ++ +
Sbjct: 1358 QLKKELAENINAVTLLREEL--SEKKSEIASLSKQLSDLGAQLESSISPSDKAEAISALS 1415
Query: 195 K--------LKAQLQ 201
K L+AQLQ
Sbjct: 1416 KQHEEQELQLQAQLQ 1430
Score = 34.3 bits (77), Expect = 0.40
Identities = 44/178 (24%), Positives = 82/178 (45%), Gaps = 26/178 (14%)
Query: 45 LRTRDSTIRDIAEKLSETAEAAEAAASAAHTIDEQWRNACEEIESLKKDS------EKQL 98
L +++ + E+L E + E + + Q R+A IE L++D K+
Sbjct: 333 LSEKEALQEQLDERLQELEKMKELHMAEKTKLITQLRDAKNLIEQLEQDKGMVITETKRQ 392
Query: 99 ELSAQKLKEYEVK-----IISLSKEKEQLSKQREAATQEANMWRSELGKARESGVILEGA 153
L +LKE E+ I ++ + E+L +Q+E + + A EL KA + E A
Sbjct: 393 MLETLELKEDEIAQLRSHIKQMTTQGEELREQKEKSERAA---FEELEKALSTAQKTEDA 449
Query: 154 LARA-----EEKVRVAEANAEAKIK-----EAVQGESAAVSEK--QELLAYVDKLKAQ 199
R E+ V A+ E +++ V+ E+A++++K +E +A + KL A+
Sbjct: 450 QRRMKMEMDEQMKAVERASEEERLRLQHELSRVRQEAASMAKKNSEEQVAALQKLHAE 507
Score = 33.5 bits (75), Expect = 0.68
Identities = 43/209 (20%), Positives = 85/209 (40%), Gaps = 4/209 (1%)
Query: 35 DEELQNFARDLRTRDSTIRDI-AEKLSETAEAAEAAASAAHTIDEQWRNACEEIESLKKD 93
D+ ++ + + L + + +RD AE++ E + + + +E+ LK+
Sbjct: 1056 DDVIEAWEKKLSQQAAELRDKHAEQMEEKEQGLGELRQKVRIVQSEKEELTKEVARLKEA 1115
Query: 94 SEKQ---LELSAQKLKEYEVKIISLSKEKEQLSKQREAATQEANMWRSELGKARESGVIL 150
Q L +L++ I+SLS+ + QL Q E + SE +E L
Sbjct: 1116 VSGQDVALAGLQGQLEQKSAVIVSLSERESQLQSQVEKLEADLGCSLSEKLSLQEELAEL 1175
Query: 151 EGALARAEEKVRVAEANAEAKIKEAVQGESAAVSEKQELLAYVDKLKAQLQRQHIDSTEV 210
+ +++ +V +A KE +S K+ L LK+ L+
Sbjct: 1176 KLLADKSQLRVSELTGQVQAAEKELQSCKSLHELSKKSLEDKSLNLKSLLEELASQLDSR 1235
Query: 211 FEKTESCSDTKHVDLTEENVDKACLSVSR 239
E+T++ + K +L + DKA ++R
Sbjct: 1236 CERTKALLEAKTNELVCTSRDKADAILAR 1264
Score = 33.1 bits (74), Expect = 0.88
Identities = 56/287 (19%), Positives = 114/287 (39%), Gaps = 44/287 (15%)
Query: 36 EELQNFARDLRTRDSTIRDIAEKLS-ETAEAAEAAASAAHTIDEQWRNACEEIES----L 90
+EL++ +++RD ++ + +KL E+A E A I + ++E
Sbjct: 1621 KELEHVNSSVKSRDGELKALEDKLELESAAKVELKRKAEQKIAAIRKQLLSQMEEKTQRY 1680
Query: 91 KKDSEKQL-ELSAQKLKEYEVKIISLSKEKEQLSKQREAATQEANMWRSELGKARESGVI 149
KD+E +L ELSAQ LKE E ++ SL + + L + RS
Sbjct: 1681 AKDTENRLSELSAQ-LKEREKQVHSLEDKLKNLESSPHPEVPAVS--RS----------- 1726
Query: 150 LEGALARAEEKVRVAEANAEAKIKEAVQGESAAVSEKQELLAYVDKLKAQLQRQHIDSTE 209
++ A E++ ++ KE + +SEK++LL +++ + + + ++
Sbjct: 1727 MQSVAASPEQEAPDSQDCTHKACKERLCMLQRRLSEKEKLLRRLEQGEGEARPSQPEAQH 1786
Query: 210 VFEKTESCSDTKHVDLTEENVDKACLSVSRSVPDPAAAECVVQMPTDQVIIQPVGD---- 265
D E++V CL E +M ++ QP+G+
Sbjct: 1787 --RALSGKLDCTRARQLEDHVLIGCL----------PEELEEKMKCSLIVSQPMGEETGN 1834
Query: 266 -----NEWSDIQATEARVADVREV---ASESEVSSLDIPVISQQGTN 304
W+ + + + +E+ A E V L+ ++ ++G +
Sbjct: 1835 NTGVKQNWASVVDSVQKTLQEKELTCQALEQRVKELESDLVRERGAH 1881
>CENE_HUMAN (Q02224) Centromeric protein E (CENP-E protein)
Length = 2663
Score = 52.0 bits (123), Expect = 2e-06
Identities = 59/249 (23%), Positives = 114/249 (45%), Gaps = 38/249 (15%)
Query: 32 LVKDEELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASAAHTIDEQWRNACEEIESLK 91
L +EEL+ L+ ++ TI ++ LSE I+++ +N +EI
Sbjct: 1473 LETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEI---- 1528
Query: 92 KDSEKQLELSAQKLKEYEVKIISLSKEKEQLSKQREAATQEANMWRSEL-GKARESGVIL 150
EK+ +L+ +++ E + + L + KE K +++A Q EL + +ES +
Sbjct: 1529 --YEKEEQLNIKQISEVQENVNELKQFKEH-RKAKDSALQSIESKMLELTNRLQESQEEI 1585
Query: 151 EGALARAEEKVRVAEA-------------NAEAKIKEAVQGE-----SAAVSEKQELLAY 192
+ + EE RV EA AK+KE+ + E AV+E QE +
Sbjct: 1586 QIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCE 1645
Query: 193 VDKLKAQLQRQHIDSTEVFEKTESCSDTKHVDLTE---ENVDKACLSVSRSVPDPAAAEC 249
++ LK Q + Q ++ + +T+++ LT+ EN+++ SV++ D + E
Sbjct: 1646 IEHLKEQFETQKLNLENI--------ETENIRLTQILHENLEE-MRSVTKERDDLRSVEE 1696
Query: 250 VVQMPTDQV 258
+++ DQ+
Sbjct: 1697 TLKVERDQL 1705
Score = 46.2 bits (108), Expect = 1e-04
Identities = 53/213 (24%), Positives = 98/213 (45%), Gaps = 25/213 (11%)
Query: 22 DDLTIMKETLLVKDEELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASAAHTIDEQWR 81
DDL ++ETL V+ ++L+ R+ TRD EK E TID+
Sbjct: 1689 DDLRSVEETLKVERDQLKENLRETITRD------LEKQEELKIVHMHLKEHQETIDKLRG 1742
Query: 82 NACE---EIESLKKDSEKQLE-LSAQKLK---EYEVKIISLSKEKEQLSKQREAATQEAN 134
E EI +++KD E + L AQ LK E + + L +++E + K R +++ +
Sbjct: 1743 IVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTD 1802
Query: 135 MWRSELGKARESGVILEGALARAEEKVRVAEANAEAKIKEAVQGESAAVSEKQELLAYVD 194
K LE + A+ +EK++ +AN I V+E Q+ ++ ++
Sbjct: 1803 -------KLSNMQKDLENSNAKLQEKIQELKANEHQLIT-----LKKDVNETQKKVSEME 1850
Query: 195 KLKAQLQRQHIDSTEVFEKTESCSDTKHVDLTE 227
+LK Q++ Q + +++ + + + H +L E
Sbjct: 1851 QLKKQIKDQSLTLSKLEIENLNLAQELHENLEE 1883
Score = 43.5 bits (101), Expect = 7e-04
Identities = 47/217 (21%), Positives = 100/217 (45%), Gaps = 25/217 (11%)
Query: 22 DDLTIMKETLLVKDEELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASAAHTIDEQWR 81
D+L +KE L VK ++L+ IR+ K+ E+ E + + +E +
Sbjct: 1352 DNLKTIKEALEVKHDQLKEH----------IRETLAKIQESQSKQEQSLNMKEKDNETTK 1401
Query: 82 NACEEIESLKKDS-----EKQLELSAQKLKEYEVKIISLSKEKEQLSKQREAATQEANMW 136
E + KDS E ++ +++L+E ++ S++KEK+ L + +E E++
Sbjct: 1402 IVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQL 1461
Query: 137 RSELGKARESGVILEGALARAEEKVRVAEANAEAKIKEAVQGESAAVSEKQELLAYVDK- 195
+ + + + EE+++VA + + +E + +SEK+ ++ + K
Sbjct: 1462 KENIKE-------IVAKHLETEEELKVAHCCLKEQ-EETINELRVNLSEKETEISTIQKQ 1513
Query: 196 LKAQLQRQHIDSTEVFEKTESCSDTKHVDLTEENVDK 232
L+A + E++EK E + K + +ENV++
Sbjct: 1514 LEAINDKLQNKIQEIYEKEEQL-NIKQISEVQENVNE 1549
Score = 41.6 bits (96), Expect = 0.002
Identities = 55/270 (20%), Positives = 117/270 (42%), Gaps = 49/270 (18%)
Query: 15 KTTDGPMDDLTIMKETLLVK------------------DEELQNFARDLRTRDSTIRDIA 56
KT DDL ++E+L ++ E+L+N L+ TI +
Sbjct: 925 KTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLK 984
Query: 57 EKLSE-TAEAAEAAASAAHTIDE--QWRNACEEIESLKKDSEKQL--ELSAQKLKEYEVK 111
K+SE + + T DE Q ++ + L+ + + L ++ ++ E + K
Sbjct: 985 SKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRK 1044
Query: 112 IISLSKEKEQLSKQREAATQEANMWRSELGKARESGV-------ILEGALAR-----AEE 159
I SL +EK +L + E+ E +++L + E + +L L + A+E
Sbjct: 1045 IFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQE 1104
Query: 160 KVRVAEANAE--------AKIKEAVQGESAAVSEKQELLAYVDKLKAQLQRQHIDSTEVF 211
K + E A+++E ++ +S + EKQ+ L V + +++Q+ ++
Sbjct: 1105 KNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQK------KIN 1158
Query: 212 EKTESCSDTKHVDLTEENVDKACLSVSRSV 241
E ++ K+ +LT E+++ L +++ +
Sbjct: 1159 EIENLKNELKNKELTLEHMETERLELAQKL 1188
Score = 41.2 bits (95), Expect = 0.003
Identities = 42/215 (19%), Positives = 96/215 (44%), Gaps = 21/215 (9%)
Query: 52 IRDIAEKLSETAEAAEAAASAAHTIDEQW---RNACEEIESLKKD-SEKQLELS------ 101
+ ++ EKL E ++ + + E+ + EIE+LK + K+L L
Sbjct: 1122 LAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETER 1181
Query: 102 ---AQKLKEYEVKIISLSKEKEQLSKQREAATQEANMWRSELGKARESGVILEGALARAE 158
AQKL E ++ S++KE++ L + +++ E + R + + +G+ + +
Sbjct: 1182 LELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGL-------QTK 1234
Query: 159 EKVRVAEANAEAKIKEAVQGESAAVSEKQELLAYVDKLKAQLQRQHIDSTEVFEKTESCS 218
E++++A + + + +E + +VSEK + L+ + + + E+ E
Sbjct: 1235 EELKIAHIHLK-EHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLP 1293
Query: 219 DTKHVDLTEENVDKACLSVSRSVPDPAAAECVVQM 253
+ K V T+E +++ L +S + ++M
Sbjct: 1294 NVKKVSETQETMNELELLTEQSTTKDSTTLARIEM 1328
Score = 37.7 bits (86), Expect = 0.036
Identities = 35/189 (18%), Positives = 89/189 (46%), Gaps = 15/189 (7%)
Query: 22 DDLTIMKETLLVKDEELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASAAHTIDEQWR 81
D+L ++ETL ++ ++L+ ++ + RD +I ++L ++ + E+
Sbjct: 1892 DNLRRVEETLKLERDQLKESLQETKARD---LEIQQELKTARMLSKEHKETVDKLREKIS 1948
Query: 82 NACEEIESLKKDSEKQLELSAQKLKEYEVKIISLSKEKEQLSKQREAATQEANMWR---- 137
+I ++KD +K + +K++E + K + L + KE ++ + + + +
Sbjct: 1949 EKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEP 2008
Query: 138 SELGKARESGVILEGALARAEEKVRVA--EANAEAKIKEAVQGESAAVSEKQELLAYVDK 195
+ L K L L + E++R+ E + +IKE+++ E+ + +A + +
Sbjct: 2009 NYLCKCEMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLK------MERDQFIATLRE 2062
Query: 196 LKAQLQRQH 204
+ A+ ++ H
Sbjct: 2063 MIARDRQNH 2071
Score = 37.7 bits (86), Expect = 0.036
Identities = 31/148 (20%), Positives = 73/148 (48%), Gaps = 6/148 (4%)
Query: 35 DEELQNFARDLRTRDSTIRDIAEKLS-ETAEAAEAAASAAHTIDE--QWRNACEEIESLK 91
++E+ N +++ + DS++ + +LS +T E E ++E Q + E +S
Sbjct: 844 NQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSPL 903
Query: 92 KDSEKQLELSAQKLKEYEVKIISLSKEKEQLSKQREAATQEANMWRSELGKARESGVILE 151
+ E++ L +KL++ ++ +L++EK+ L + +E+ E + +S++ + +
Sbjct: 904 QTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQ 963
Query: 152 GALARAEEKVRVAEA---NAEAKIKEAV 176
L A E ++ + ++KI E V
Sbjct: 964 EQLRNALESLKQHQETINTLKSKISEEV 991
Score = 34.7 bits (78), Expect = 0.30
Identities = 52/243 (21%), Positives = 97/243 (39%), Gaps = 53/243 (21%)
Query: 21 MDDLTIMKETLLVKDEELQNFA-------RDLRTR---DSTIRDIAEKLSET------AE 64
+D++ KE LL+K + LQ RDL+ D I +I + SE+ E
Sbjct: 2161 IDEVEKQKE-LLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTE 2219
Query: 65 AAEAAASAAHTID--EQWRNACEEIESLKKDSEKQLELSAQKLKEYEVKIISLSKEKEQL 122
+ ++ E+W N +IE LK +K+ + Q + +II++ E +
Sbjct: 2220 FQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEF 2279
Query: 123 SKQREAATQEANMWRSELGKARE-----------------SGV-------------ILEG 152
++ ++E W +L +E SG +
Sbjct: 2280 EERSATISKE---WEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSR 2336
Query: 153 ALARAEEKVRVAEANAEAKIKEAVQGESAAVSEKQELLAYVDKLKAQLQRQHIDSTEVFE 212
A EK+R E N+ + KE+ + + + + Q+ L + + A+LQ + +S + E
Sbjct: 2337 ATQLTTEKIRELE-NSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLE 2395
Query: 213 KTE 215
KT+
Sbjct: 2396 KTK 2398
Score = 33.9 bits (76), Expect = 0.52
Identities = 51/198 (25%), Positives = 89/198 (44%), Gaps = 26/198 (13%)
Query: 57 EKLSETAEAAEAAASAAHTIDEQWRNACEEIESLKKDSEKQLELSAQKLKEYEVKIISLS 116
+K+SET E + + EQ + ++ +L + ++L L+ +K +E + +I SL+
Sbjct: 1296 KKVSETQETM----NELELLTEQ--STTKDSTTLARIEMERLRLN-EKFQESQEEIKSLT 1348
Query: 117 KEKEQLSKQREAA----TQEANMWRSELGKARESGVILEGALARAE---EKVRVAEANAE 169
KE++ L +EA Q R L K +ES E +L E E ++ +
Sbjct: 1349 KERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQ 1408
Query: 170 AKIKEA--------VQGESAAVSEKQELLAYVDKLKAQLQR-QHIDSTEVFEKTESCSD- 219
K K++ + G S + E + + V K K LQR Q + +E + E+ +
Sbjct: 1409 FKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEI 1468
Query: 220 -TKHVDLTEE-NVDKACL 235
KH++ EE V CL
Sbjct: 1469 VAKHLETEEELKVAHCCL 1486
Score = 32.3 bits (72), Expect = 1.5
Identities = 34/187 (18%), Positives = 76/187 (40%), Gaps = 8/187 (4%)
Query: 36 EELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASAAHTIDEQWRNACEEIESLKKDSE 95
E+L+N L+T + I EKL +T E + + + + E + LK D
Sbjct: 894 EQLENRDSPLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIH 953
Query: 96 KQLELSAQKLKEYEVKIISLSKEKEQLSKQREAATQEANMWRSELGKARESGVILEGALA 155
+ ++ ++ + SL + +E ++ + ++E + E+ + +
Sbjct: 954 DTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMV 1013
Query: 156 RAEEKVRVAEAN-----AEAKIKEAVQGES---AAVSEKQELLAYVDKLKAQLQRQHIDS 207
++K + N A+ K E ++ + + + EK EL ++ + A+ ++ D
Sbjct: 1014 GIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDL 1073
Query: 208 TEVFEKT 214
E E T
Sbjct: 1074 KENIEMT 1080
Score = 30.0 bits (66), Expect = 7.5
Identities = 22/109 (20%), Positives = 49/109 (44%), Gaps = 17/109 (15%)
Query: 34 KDEELQNFARDLRTRDSTIR-------DIAEKLSETAEAAEAAASAAHTIDE-------- 78
K E++N +L+ ++ T+ ++A+KL+E E ++ + E
Sbjct: 1156 KINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETE 1215
Query: 79 --QWRNACEEIESLKKDSEKQLELSAQKLKEYEVKIISLSKEKEQLSKQ 125
R EIE+ ++++L+++ LKE++ I L + + + Q
Sbjct: 1216 RDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQ 1264
Score = 29.6 bits (65), Expect = 9.8
Identities = 54/261 (20%), Positives = 107/261 (40%), Gaps = 21/261 (8%)
Query: 34 KDEELQ------NFARDLRTRDSTIRDIAEKLSETAEAAEAAASAAHTIDEQWRNACEEI 87
KD+E+Q N ++ R+ +D+ +LS E + E + +++
Sbjct: 546 KDQEMQLIHEISNLKNLVKHREVYNQDLENELSSKVELLREKEDQIKKLQEYIDS--QKL 603
Query: 88 ESLKKDSEKQLELSAQKLKEYEVKIISLSKEKEQLSKQREAATQEANMWRSELGKARESG 147
E++K D LE S + K+ +K E L +RE+A RSE + +E
Sbjct: 604 ENIKMDLSYSLE-SIEDPKQ--MKQTLFDAETVALDAKRESA-----FLRSENLELKEKM 655
Query: 148 VILEGALARAEEKVRVAEANAEAKIKEAVQGESAAVSEKQELLAYVDKLKAQLQRQHIDS 207
L + E +++ ++ EAK K V E S E+ + ++ + + +
Sbjct: 656 KELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCN 715
Query: 208 TEVFEKTESCSDTKHVDLTEENV---DKACLSVSRSVP-DPAAAECVVQMPTDQV-IIQP 262
E+ K + ++ E + LS +S+P + +Q ++++ II
Sbjct: 716 LELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITS 775
Query: 263 VGDNEWSDIQATEARVADVRE 283
D +S++ E+RV + E
Sbjct: 776 EKDKLFSEVVHKESRVQGLLE 796
>SMI1_YARLI (Q6CDX0) KNR4/SMI1 homolog
Length = 713
Score = 51.6 bits (122), Expect = 2e-06
Identities = 62/241 (25%), Positives = 96/241 (39%), Gaps = 30/241 (12%)
Query: 17 TDGPMDDLTIM---KETLLVKDEELQNFARDLRT----RDSTIRDIAEKLSETAEAA--- 66
T P DL I+ ++T +KD+ LR T I E L E+ E
Sbjct: 453 TSKPAQDLDIVDLNEDTATIKDKGKATMGSALRKTIVDESKTAHTIVEPLEESEEIKGKG 512
Query: 67 --------EAAASAAHTIDEQWRNACEEIES----LKKDSEKQLELSAQKLKEYEVKIIS 114
EAA A E+ + A +E LKK +EK E A+ K+ +
Sbjct: 513 KGKEEDVNEAAEKAKVEATEKTKKAAKEAADKEAELKKAAEKAAEEKAKAEKK-----AA 567
Query: 115 LSKEKEQLSKQREAATQEANMWRSELGKARESGVILEGALARAEEKVRVAEANAEAKIKE 174
++EKE+ + A +E + + E+ KA + A A AE A+ AEA +
Sbjct: 568 EAREKEEKEAKAAAKAKEEELKKEEVAKAAAKAEEEQKATAAAEAAKAEAKRAAEADASK 627
Query: 175 AVQGESAAVSEKQELLAYVDKLKAQLQRQHIDSTEV---FEKTESCSDTKHVDLTEENVD 231
V+ E AA E +E A ++ K + + + E E+ + +D D EE
Sbjct: 628 KVEAEKAAAEESKESKAESEESKVERDLEELKIDEENGNAEEADEEADDDDEDDEEEGDS 687
Query: 232 K 232
K
Sbjct: 688 K 688
>MYHB_HUMAN (P35749) Myosin heavy chain, smooth muscle isoform (SMMHC)
Length = 1972
Score = 50.4 bits (119), Expect = 5e-06
Identities = 57/281 (20%), Positives = 114/281 (40%), Gaps = 40/281 (14%)
Query: 13 TNKTTDGPMDDLTIMKETLLVKDEELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASA 72
TNK M+DL K+ + EL+ R L T+ ++ E+L + +A E
Sbjct: 1505 TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATE----- 1559
Query: 73 AHTIDEQWRNACEEIESLKKDSEKQLELSAQKLK-EYEVKIISLSKEKEQLSKQREAATQ 131
D++ +LE++ Q LK ++E L EQ ++R +
Sbjct: 1560 --------------------DAKLRLEVNMQALKGQFE---RDLQARDEQNEEKRRQLQR 1596
Query: 132 EANMWRSELGKARESGVILEGALARAEEKVRVAEANAEAKIKEAVQGESAAVSEKQELLA 191
+ + + +EL R+ + A + E ++ E A++ A++G A+ + ++L A
Sbjct: 1597 QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS----AIKGREEAIKQLRKLQA 1652
Query: 192 YVDKLKAQLQRQHIDSTEVF---EKTESCSDTKHVDLTEENVDKACLSVSRSVPDPAAAE 248
+ + +L+ E+F ++ E + + DL + D A +R D E
Sbjct: 1653 QMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEE 1712
Query: 249 CVVQMPTDQVIIQPVGDNEWSDIQATEARVADVREVASESE 289
++ + + D + + EAR+A + E E +
Sbjct: 1713 LAEELASSLSGRNALQDEK----RRLEARIAQLEEELEEEQ 1749
Score = 45.4 bits (106), Expect = 2e-04
Identities = 46/202 (22%), Positives = 106/202 (51%), Gaps = 21/202 (10%)
Query: 27 MKETLLVKDEELQN-FAR---DLRTRDSTIRDIAE---KLSETAEAAEAAASAAHTIDEQ 79
+K L K+EELQ AR ++ +++ ++ I E +S+ E ++ +A + ++Q
Sbjct: 1081 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1140
Query: 80 WRNACEEIESLKKDSEKQLELSA--QKLKEYEVKIISLSKEKEQLSKQREAATQEANMWR 137
R+ EE+E+LK + E L+ +A Q+L+ +K +++++ ++A +E
Sbjct: 1141 KRDLGEELEALKTELEDTLDSTATQQELR---------AKREQEVTVLKKALDEETRSHE 1191
Query: 138 SELGKARESGVILEGALARAEEKVRVAEANAEAKIKEAVQGESAAVSEKQELLAYVDKLK 197
+++ + R+ L E+ + A+AN + K K+ ++ E+A ++ + +L K +
Sbjct: 1192 AQVQEMRQKHAQAVEELTEQLEQFKRAKANLD-KNKQTLEKENADLAGELRVLGQA-KQE 1249
Query: 198 AQLQRQHIDSTEVFEKTESCSD 219
+ +++ +++ +V E CSD
Sbjct: 1250 VEHKKKKLEA-QVQELQSKCSD 1270
Score = 42.0 bits (97), Expect = 0.002
Identities = 39/187 (20%), Positives = 86/187 (45%), Gaps = 17/187 (9%)
Query: 27 MKETLLVKDEELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASAAHTIDEQWRNACEE 86
M+ L K +EL+ ++ R D ++L AE A +D + EE
Sbjct: 909 MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ-----AERKKMAQQMLDLE--EQLEE 961
Query: 87 IESLKKDSEKQLELSAQKLKEYEVKIISLSKEKEQLSKQREAATQEANMWRSELGKARES 146
E+ ++ + + + K+K+ E +I+ + + +LSK+R+ + + + L + E
Sbjct: 962 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021
Query: 147 GVIL-------EGALARAEEKVRVAEANAE--AKIKEAVQGESAAVSEK-QELLAYVDKL 196
L E ++ E +++ E + + K+K ++G+++ E+ +L A + +L
Sbjct: 1022 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1081
Query: 197 KAQLQRQ 203
K QL ++
Sbjct: 1082 KMQLAKK 1088
Score = 38.9 bits (89), Expect = 0.016
Identities = 28/145 (19%), Positives = 64/145 (43%), Gaps = 4/145 (2%)
Query: 5 LRNTLGMMTNKTTDGPMDDLTIMKETLLVKDEELQNFARDLRTRDSTIRDIAEKLSETAE 64
LR+ L M + ++ + +E+++ AR+ + +++ +KL E
Sbjct: 1797 LRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILL 1856
Query: 65 AAEAAASAAHTIDEQWRNACEEIESLKKDSEKQLELSAQKLKEYEVKIISLSKEKEQLSK 124
E A EQ++ E+ + K ++QLE + ++ + L +E ++ ++
Sbjct: 1857 QVEDERKMA----EQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATE 1912
Query: 125 QREAATQEANMWRSELGKARESGVI 149
EA +E N +S+L + E+ +
Sbjct: 1913 SNEAMGREVNALKSKLRRGNETSFV 1937
Score = 37.0 bits (84), Expect = 0.061
Identities = 46/229 (20%), Positives = 94/229 (40%), Gaps = 31/229 (13%)
Query: 27 MKETLLVKDEELQNFARDLRTRDSTIRDIAEKLSETAEAA----------EAAASAAHTI 76
+++ +LV D++ +++ + + I D+ L+E E A E+ S
Sbjct: 983 LEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR 1042
Query: 77 DEQWRNACEEIESLKKDSEKQLELSAQKLKEYEVKI----ISLSKEKEQLSKQREAATQE 132
++ + +E+E LK+ E +++ + + +I + L+K++E+L E
Sbjct: 1043 LKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDE 1102
Query: 133 ANMWRSELGKARESGVILEGALARAEEKV---RVAEANAEAK----------IKEAVQGE 179
+ L K RE LEG ++ +E + R A AE + +K ++
Sbjct: 1103 IAQKNNALKKIRE----LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDT 1158
Query: 180 SAAVSEKQELLAYVDKLKAQLQRQHIDSTEVFEKTESCSDTKHVDLTEE 228
+ + +QEL A ++ L++ + T E KH EE
Sbjct: 1159 LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEE 1207
Score = 36.6 bits (83), Expect = 0.080
Identities = 43/156 (27%), Positives = 75/156 (47%), Gaps = 19/156 (12%)
Query: 88 ESLKKDSEKQLELSAQKLKEYEVKIISLSKEKEQLSKQREAATQ---EANMWRSEL-GKA 143
+ L+K E+Q + + +LKE E K L++EK L +Q +A T+ EA R L K
Sbjct: 859 DELQKTKERQ-QKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKK 917
Query: 144 RESGVILEGALARAEEKV-RVAEANAEAK--------IKEAVQGESAAVSEKQELLAYVD 194
+E IL AR EE+ R + AE K ++E ++ E AA + Q ++
Sbjct: 918 QELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQ-----LE 972
Query: 195 KLKAQLQRQHIDSTEVFEKTESCSDTKHVDLTEENV 230
K+ A+ + + ++ + ++ +K L EE +
Sbjct: 973 KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERI 1008
Score = 34.7 bits (78), Expect = 0.30
Identities = 49/229 (21%), Positives = 91/229 (39%), Gaps = 43/229 (18%)
Query: 35 DEELQNFARDLRTRDSTIRDI---AEKLSE-------TAEAAEAAASAAHTIDEQWRNAC 84
+EEL+ ++ +R AE+LS TA+ E+A +++ R+
Sbjct: 1742 EEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKL 1801
Query: 85 EEIESLKKDSEKQLELSAQKLKEYEVKIISLSKEKEQLSKQREAATQE------------ 132
E+E K K + E KI L ++ EQ +++++AAT+
Sbjct: 1802 HEMEGAVKSKFKST------IAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEIL 1855
Query: 133 ---------ANMWRSELGKARESGVILEGALARAEEKVRVAEANAEAKIKEAVQGESAAV 183
A ++ + K L+ L AEE+ + AN + +Q E
Sbjct: 1856 LQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINAN-----RRKLQRELDEA 1910
Query: 184 SEKQELLA-YVDKLKAQLQRQHIDSTEVFEKTESCSDTKHVDLTEENVD 231
+E E + V+ LK++L+R + S ++ ++ D +EE D
Sbjct: 1911 TESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEEETD 1959
Score = 32.0 bits (71), Expect = 2.0
Identities = 39/192 (20%), Positives = 86/192 (44%), Gaps = 14/192 (7%)
Query: 27 MKETLLVKDEELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASAAHTIDEQWRNACEE 86
++ L+ E+L R + D ++AE+L+ + A ++ + EE
Sbjct: 1685 LEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1744
Query: 87 IESLKKDSEKQLELSAQKLKEYEVKIISLSKE---KEQLSKQREAATQEANMWRSEL-GK 142
+E + + +E + ++++ + LS E + +++ E+A Q+ EL K
Sbjct: 1745 LE----EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSK 1800
Query: 143 ARESGVILEGALARAEEKVRVAEANAE-AKIKEAVQGESAAVSEKQELLAYVDKLKAQLQ 201
E +EGA+ +++ K +A A+ A+++E V+ E+ + L DK ++
Sbjct: 1801 LHE----MEGAV-KSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEIL 1855
Query: 202 RQHIDSTEVFEK 213
Q D ++ E+
Sbjct: 1856 LQVEDERKMAEQ 1867
>TPM1_PIG (P42639) Tropomyosin 1 alpha chain (Alpha-tropomyosin)
Length = 284
Score = 50.1 bits (118), Expect = 7e-06
Identities = 49/216 (22%), Positives = 97/216 (44%), Gaps = 19/216 (8%)
Query: 22 DDLTIMKETLLVKDEELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASAAHTI----- 76
D+L +++ L ++EL ++ L+ + ++AEK + AEA A+ + +
Sbjct: 41 DELVSLQKKLKATEDELDKYSEALKDAQEKL-ELAEKKATDAEADVASLNRRIQLFEEEL 99
Query: 77 ---DEQWRNACEEIESLKKDSE------KQLELSAQKLKE-YEVKIISLSKEK---EQLS 123
E+ A +++E +K ++ K +E AQK +E E++ I L + K E
Sbjct: 100 DRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDAD 159
Query: 124 KQREAATQEANMWRSELGKARESGVILEGALARAEEKVRVAEANAEAKIKEAVQGESAAV 183
++ E ++ + S+L +A E + EG A EE+++ N ++ +A +
Sbjct: 160 RKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKED 219
Query: 184 SEKQELLAYVDKLKAQLQRQHIDSTEVFEKTESCSD 219
++E+ DKLK R V + +S D
Sbjct: 220 KYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDD 255
Score = 38.5 bits (88), Expect = 0.021
Identities = 43/174 (24%), Positives = 69/174 (38%), Gaps = 14/174 (8%)
Query: 30 TLLVKDEELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASAAHTIDEQWRNACEE--- 86
T L K EE + A + I A+K E E E A I E EE
Sbjct: 108 TALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVAR 167
Query: 87 ----IESLKKDSEKQLELSAQKLKEYEVKIISLSKEKEQLSKQREAATQEANMWRSELGK 142
IES + +E++ ELS K E E ++ +++ + L Q E +Q+ + + E+
Sbjct: 168 KLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDKYEEEI-- 225
Query: 143 ARESGVILEGALARAEEKVRVAEANAEAKIKEAVQGESAAVSEKQELLAYVDKL 196
+L L AE + AE + K E ++K + A ++L
Sbjct: 226 -----KVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEEL 274
Score = 37.7 bits (86), Expect = 0.036
Identities = 37/182 (20%), Positives = 78/182 (42%), Gaps = 11/182 (6%)
Query: 57 EKLSETAEAAEAAASAAHTIDEQWRNACEEIESLKKDSEKQLELSAQKLKEYEVKIISLS 116
E + A+ AEA AA +Q + ++ K +E +L+ ++ LK+ + K+
Sbjct: 16 ENALDRADEAEADKKAAEDRSKQLEDELVSLQKKLKATEDELDKYSEALKDAQEKLELAE 75
Query: 117 KEKEQLSKQREAATQEANMWRSELGKARESGVI-------LEGALARAEEKVRVAEANAE 169
K+ + + ++ EL +A+E E A +E ++V E+ A+
Sbjct: 76 KKATDAEADVASLNRRIQLFEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQ 135
Query: 170 AKIKEAVQGESAAVSEKQELLAYVDKLKAQLQRQHI---DSTEVFEKTESCSDTKHVDLT 226
K +E ++ + + E + + D+ ++ R+ + E E+ S+ K +L
Sbjct: 136 -KDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELE 194
Query: 227 EE 228
EE
Sbjct: 195 EE 196
>MYH9_RAT (Q62812) Myosin heavy chain, nonmuscle type A (Cellular
myosin heavy chain, type A) (Nonmuscle myosin heavy
chain-A) (NMMHC-A)
Length = 1961
Score = 50.1 bits (118), Expect = 7e-06
Identities = 51/205 (24%), Positives = 93/205 (44%), Gaps = 22/205 (10%)
Query: 27 MKETLLVKDEELQ-------NFARDLRTRDSTIRDIAEKLSETAEAAEAAASAAHTIDEQ 79
+K L K+EELQ A IR++ ++SE E E+ + + ++Q
Sbjct: 1074 LKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELETQISELQEDLESERACRNKAEKQ 1133
Query: 80 WRNACEEIESLKKDSEKQL-------ELSAQKLKEYEVKIISLSKEKEQLSKQREAATQE 132
R+ EE+E+LK + E L EL ++ +E EV I L K E +K EA QE
Sbjct: 1134 KRDLGEELEALKTELEDTLDSTAAQQELRSK--REQEVSI--LKKTLEDEAKTHEAQIQE 1189
Query: 133 ANMWRS----ELGKARESGVILEGALARAEEKVRVAEANAEAKIKEAVQGESAAVSEKQE 188
S EL + E ++ L +A++ + ++K +QG+ + ++++
Sbjct: 1190 MRQKHSQAVEELAEQLEQTKRVKATLEKAKQTLENERGELANEVKALLQGKGDSEHKRKK 1249
Query: 189 LLAYVDKLKAQLQRQHIDSTEVFEK 213
+ A + +L+ + TE+ +K
Sbjct: 1250 VEAQLQELQVKFSEGERVRTELADK 1274
Score = 38.9 bits (89), Expect = 0.016
Identities = 42/218 (19%), Positives = 90/218 (41%), Gaps = 20/218 (9%)
Query: 18 DGPMDDLTIMKETLLVKDEELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASAAHTID 77
+ ++D + + ++L+ +DL T E+ + +A
Sbjct: 1596 EAELEDERKQRSIAMAARKKLEMDLKDLEAHIDTANKNREEAIKQLRKLQAQMKDCMRDV 1655
Query: 78 EQWRNACEEIESLKKDSEKQLELSAQKLKEYEVKIISLSKEKEQLSKQREAATQEANMWR 137
+ R + EEI + K++EK KLK E ++I L +E + + A QE +
Sbjct: 1656 DDTRASREEILAQAKENEK-------KLKSMEAEMIQLQEELAAAERAKRQAQQERDELA 1708
Query: 138 SELGKARESGVI-------LEGALARAEEKVRVAEANAEA---KIKEA---VQGESAAVS 184
E+ + G + LE +A EE++ + N E ++K+A + + ++
Sbjct: 1709 DEIANSSGKGALALEEKRRLEALIALLEEELEEEQGNTELINDRLKKANLQIDQINTDLN 1768
Query: 185 EKQELLAYVDKLKAQLQRQHIDSTEVFEKTESCSDTKH 222
++ + + QL+RQ+ + ++ ES +K+
Sbjct: 1769 LERSHAQKNENARQQLERQNKELKAKLQEMESAVKSKY 1806
Score = 36.2 bits (82), Expect = 0.10
Identities = 47/212 (22%), Positives = 85/212 (39%), Gaps = 30/212 (14%)
Query: 14 NKTTDGPMDDLTIMKETLLVKDEELQNFARDLRTRDSTIRDIAEKLSETAEAAE------ 67
NK M+DL K+ + EL+ R L + ++ E+L + +A E
Sbjct: 1500 NKQFRTEMEDLMSSKDDVGKSVHELEKSNRALEQQVEEMKTQLEELEDELQATEDAKLRL 1559
Query: 68 ----AAASAAHTIDEQWRN------------ACEEIESLKKDSEKQLELSAQKLKEYEVK 111
A A D Q R+ E+E+ +D KQ ++ K+ E+
Sbjct: 1560 EVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSIAMAARKKLEMD 1619
Query: 112 IISLSKEKEQLSKQREAATQEANMWRSELGKARESGVILEGALARAEEKVRVAEANAEAK 171
+ L + +K RE A ++ ++++ ++ A EE + A+ N E K
Sbjct: 1620 LKDLEAHIDTANKNREEAIKQLRKLQAQMKDCMRD---VDDTRASREEILAQAKEN-EKK 1675
Query: 172 IKEAVQGESAAVSEKQELLAYVDKLKAQLQRQ 203
+K A + + QE LA ++ K Q Q++
Sbjct: 1676 LKSM----EAEMIQLQEELAAAERAKRQAQQE 1703
Score = 35.0 bits (79), Expect = 0.23
Identities = 32/120 (26%), Positives = 61/120 (50%), Gaps = 16/120 (13%)
Query: 88 ESLKKDSEKQLELSAQKLKEYEVKIIS----LSKEKEQLSKQREAATQEANMWRSELGKA 143
E L++++ ++L LS KLK+ E + S L +E+E+ + E + +++ K
Sbjct: 1315 ELLQEENRQKLSLST-KLKQMEDEKNSFREQLEEEEEEAKRNLEKQIATLHAQVTDMKKK 1373
Query: 144 RESGVILEGALARAEEKVRVAEANAEAKIKEAVQGESAAVSEKQELLAYVDKLKAQLQRQ 203
E GV G L AEE A+ ++++ ++G S + EK ++K K +LQ++
Sbjct: 1374 MEDGV---GCLETAEE--------AKRRLQKDLEGLSQRLEEKVAAYDKLEKTKTRLQQE 1422
Score = 33.5 bits (75), Expect = 0.68
Identities = 28/153 (18%), Positives = 66/153 (42%), Gaps = 5/153 (3%)
Query: 23 DLTIMKETLLVKDEELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASAAHT-IDEQWR 81
DL + + + Q R + + ++++ + +A+ AA A ++EQ
Sbjct: 1766 DLNLERSHAQKNENARQQLERQNKELKAKLQEMESAVKSKYKASIAALEAKIAQLEEQLD 1825
Query: 82 NACEEIESLKKDSEKQLELSAQKLKEYEVKIISLSKEKEQLSKQREAATQEANMWRSELG 141
N +E ++ + KQ+ + +KLK+ +++ + EQ Q + A+ + +L
Sbjct: 1826 NETKE----RQAASKQVRRAEKKLKDVLLQVEDERRNAEQFKDQADKASTRLKQLKRQLE 1881
Query: 142 KARESGVILEGALARAEEKVRVAEANAEAKIKE 174
+A E + + + ++ A A+A +E
Sbjct: 1882 EAEEEAQRANASRRKLQRELEDATETADAMNRE 1914
>REST_HUMAN (P30622) Restin (Cytoplasmic linker protein-170 alpha-2)
(CLIP-170) (Reed-Sternberg intermediate filament
associated protein)
Length = 1427
Score = 49.7 bits (117), Expect = 9e-06
Identities = 44/197 (22%), Positives = 90/197 (45%), Gaps = 9/197 (4%)
Query: 34 KDEELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASAAHTIDEQWRNACEEIESLKKD 93
+ + + R+L+ R+ + ++ E LSE ++ E + E++ A EE S+++
Sbjct: 803 ESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRS 862
Query: 94 SEKQLELSAQKLKEYEVKIISLSKEKEQLSKQREAATQEANMWRSELGKARE--SGVILE 151
++ + QK +++ + L K +E L+ EA +E + +L KA+E I E
Sbjct: 863 MQETVNKLHQKEEQFNMLSSDLEKLRENLA-DMEAKFREKDEREEQLIKAKEKLENDIAE 921
Query: 152 GALARAEEKVRVAEANAEAKIKEAVQGESAAVSEKQELLAYVDKLKAQLQRQHIDSTEVF 211
+ ++ + N E ++KE V E Q L ++ + LQ+ D T
Sbjct: 922 IMKMSGDNSSQLTKMNDELRLKE------RDVEELQLKLTKANENASFLQKSIEDMTVKA 975
Query: 212 EKTESCSDTKHVDLTEE 228
E+++ + KH + +E
Sbjct: 976 EQSQQEAAKKHEEEKKE 992
Score = 42.0 bits (97), Expect = 0.002
Identities = 51/239 (21%), Positives = 96/239 (39%), Gaps = 34/239 (14%)
Query: 4 SLRNTLGMMTNKTTDGPMDDLTI---MKET---LLVKDEELQNFARDLRTRDSTIRDIAE 57
+L L ++ K + + +++ M+ET L K+E+ + DL + D+
Sbjct: 837 TLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEA 896
Query: 58 KLSETAEAAEAAASAAHTIDEQWRNACEEIESLKKDSEKQL-------ELSAQKLKEYEV 110
K E E E A E+ N EI + D+ QL L + ++E ++
Sbjct: 897 KFREKDEREEQLIKAK----EKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQL 952
Query: 111 KIISLSKEKEQLSKQREAATQEANMWRSELGKARESGVILEGALARAEEKVRVAEANAEA 170
K+ ++ L K E T +A + E K E EEK + E
Sbjct: 953 KLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHE------------EEKKEL-----ER 995
Query: 171 KIKEAVQGESAAVSEKQELLAYVDKLKAQLQRQHIDSTEVFEKTESCSDTKHVDLTEEN 229
K+ + + + ++ QEL A ++ ++ + +H + + +KT ++ K EEN
Sbjct: 996 KLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREEN 1054
Score = 41.6 bits (96), Expect = 0.002
Identities = 50/262 (19%), Positives = 106/262 (40%), Gaps = 18/262 (6%)
Query: 45 LRTRDSTIRDIAEKLSETAEAAEAAASAAHTIDEQWRNACEEIESLKKDSEKQLELSAQK 104
++ + ++ E L+ + + A + +D N + +E L K S++ L + QK
Sbjct: 1081 MQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNK-SKELLTVENQK 1139
Query: 105 LKEYEVKIISLSKEKEQLSKQREAATQEANMWRSELGKARESGVILEGALARAEEKVRVA 164
++E+ +I +L + Q S+Q A +E ELG++R+ + +K+
Sbjct: 1140 MEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDE--------VTSHQKLEEE 1191
Query: 165 EANAEAKIKEAVQGESAAVSEKQELLAYVDKLKAQLQRQ-HIDSTEVFEKTESCSDTKHV 223
+ ++ E + ES + + D+ KA LQ+ I S + EK ++
Sbjct: 1192 RSVLNNQLLEMKKRESKFIKD-------ADEEKASLQKSISITSALLTEKDAELEKLRNE 1244
Query: 224 DLTEENVDKACLSVSRSVPDPAAAECVVQMPTDQVIIQ-PVGDNEWSDIQATEARVADVR 282
+ + S+ V + + +++ + +Q + S AD
Sbjct: 1245 VTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADED 1304
Query: 283 EVASESEVSSLDIPVISQQGTN 304
E A ES++ L+ ++ Q N
Sbjct: 1305 ERAQESQIDFLNSVIVDLQRKN 1326
Score = 40.8 bits (94), Expect = 0.004
Identities = 43/201 (21%), Positives = 85/201 (41%), Gaps = 30/201 (14%)
Query: 37 ELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASAAHTIDEQWRNACEEIESLKKDSEK 96
+L +LR ++ + ++ KL++ E A + + + + +E ++ +K
Sbjct: 932 QLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKK 991
Query: 97 QLELSAQKLKEYEVKIISLSKEKEQLSKQREAATQEANMWRSELGKARESGVILEGALAR 156
+LE +KL + E K+ + + ++L + E AT E E+ + + ++
Sbjct: 992 ELE---RKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLL------- 1041
Query: 157 AEEKVRVAEANAEAKIKEAVQGESAAVSEKQELLAYVDKLKAQLQRQHIDSTEVF----- 211
+ E K+K A + S + E +EL DK KA + D+ ++
Sbjct: 1042 ----------DTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAE--DAMQIMEQMTK 1089
Query: 212 EKTE---SCSDTKHVDLTEEN 229
EKTE S DTK + +N
Sbjct: 1090 EKTETLASLEDTKQTNAKLQN 1110
Score = 37.4 bits (85), Expect = 0.047
Identities = 60/303 (19%), Positives = 116/303 (37%), Gaps = 57/303 (18%)
Query: 38 LQNFARDLRTRDSTIRDIAEKLSETAEAAEA---------AASAAHTIDEQWRNACEEIE 88
+ +DL R + ++ +L A + +S ++ + EI
Sbjct: 501 IMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREIT 560
Query: 89 SLKKDSEKQLELSAQKLKEYEVKIISLSKEKEQLSKQREAATQEAN----MWRSELGKAR 144
SLK+ + E +++K LSKE E L + E A +E + +W+S+
Sbjct: 561 SLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSK----- 615
Query: 145 ESGVILEGALARAEEKVRVAEANAEAKIKEAVQGESAAVSEKQELLAYVDKLKAQLQRQH 204
LE A+A + +A E K+ + +G +E EL ++K++ Q +
Sbjct: 616 -----LETAIASHQ------QAMEELKVSFS-KGLGTETAEFAELKTQIEKMRLDYQHE- 662
Query: 205 IDSTEVFEKTESCSDTKHVDLTEENVDKA------CLSVSRSVPDPAAAECVVQMPTDQV 258
I++ + + +E + K ++ + K L RS D A + +V+M
Sbjct: 663 IENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLN 722
Query: 259 IIQ--------------------PVGDNEWSDIQATEARVADVREVASESEVSSLDIPVI 298
+Q V DN S ++ATE ++ D+ + S ++ +
Sbjct: 723 KLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKL 782
Query: 299 SQQ 301
QQ
Sbjct: 783 RQQ 785
Score = 35.4 bits (80), Expect = 0.18
Identities = 44/172 (25%), Positives = 75/172 (43%), Gaps = 12/172 (6%)
Query: 13 TNKTTDGPMDDLTIMKETLLVKDEELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASA 72
T +T ++L +KE L EEL N +++L T ++ + K ET + A A S
Sbjct: 1101 TKQTNAKLQNELDTLKENNLKNVEEL-NKSKELLTVENQKMEEFRKEIETLKQAAAQKSQ 1159
Query: 73 AHT--------IDEQWRNACEEIESLKKDSEKQLELSAQ--KLKEYEVKII-SLSKEKEQ 121
+ + E+ + +E+ S +K E++ L+ Q ++K+ E K I +EK
Sbjct: 1160 QLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKAS 1219
Query: 122 LSKQREAATQEANMWRSELGKARESGVILEGALARAEEKVRVAEANAEAKIK 173
L K + +EL K R +L G A A+ V + K+K
Sbjct: 1220 LQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVK 1271
>PLE1_RAT (P30427) Plectin 1 (PLTN) (PCN)
Length = 4687
Score = 49.7 bits (117), Expect = 9e-06
Identities = 41/161 (25%), Positives = 76/161 (46%), Gaps = 17/161 (10%)
Query: 53 RDIAEKLSETAEAAEAAASAAHTIDEQWRNACEEIESLKKDSEKQLELSAQKLK------ 106
R++ ++ E E AA A +Q R+ EE++ L++ SE +++ AQ+++
Sbjct: 1531 RELQRRMQEEVTRREEAAVDAQ---QQKRSIQEELQHLRQSSEAEIQAKAQQVEAAERSR 1587
Query: 107 ---EYEVKIISLSKEKEQLSKQREAATQEANMWRSELGKARESGVILEGALARAEEKVR- 162
E E++++ L E + +QR A E R+ +A + R +V+
Sbjct: 1588 MRIEEEIRVVRLQLETTE--RQRGGAEDELQALRARAEEAEAQKRQAQEEAERLRRQVQD 1645
Query: 163 --VAEANAEAKIKEAVQGESAAVSEKQELLAYVDKLKAQLQ 201
+ AEA++ V+ E+ A EKQ L +D+LK Q +
Sbjct: 1646 ESQRKRQAEAELALRVKAEAEAAREKQRALQALDELKLQAE 1686
Score = 45.8 bits (107), Expect = 1e-04
Identities = 48/217 (22%), Positives = 88/217 (40%), Gaps = 12/217 (5%)
Query: 23 DLTIMKETLLVKDEELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASAAHTIDEQWRN 82
+L + + K +L+ ++ + +R+ AE+ ++ AE A A E+W+
Sbjct: 1717 ELQSKRPSFAEKTAQLERTLQEEHVTVTQLREEAERRAQQQAEAERAREEAERELERWQL 1776
Query: 83 ACEEIESLKKDSEK--------QLELSAQKLKEYEVKIISLSKEKEQLSKQREAATQEAN 134
E L+ +E+ Q + QK +E E + K +EQ +QRE A QE
Sbjct: 1777 KANEALRLRLQAEEVAQQKSLAQADAEKQK-EEAEREARRRGKAEEQAVRQRELAEQELE 1835
Query: 135 MWRSELGKARESGVILEGALARAEEKVRVAEAN---AEAKIKEAVQGESAAVSEKQELLA 191
R + + E L R + E E ++ +AA ++QEL A
Sbjct: 1836 KQRQLTEGTAQQRLAAEQELIRLRAETEQGEHQRQLLEEELARLQHEATAATQKRQELEA 1895
Query: 192 YVDKLKAQLQRQHIDSTEVFEKTESCSDTKHVDLTEE 228
+ K++A+++ E++ S S+ L E
Sbjct: 1896 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1932
Score = 43.9 bits (102), Expect = 5e-04
Identities = 53/185 (28%), Positives = 82/185 (43%), Gaps = 28/185 (15%)
Query: 42 ARDLRTRDSTIRDIAEKLSETAEAAEAAASAAHTIDEQWRNACEEIESLKKDSEKQLELS 101
A ++ + S + AEK E AE A +EQ A + E +++ EKQ +L+
Sbjct: 1788 AEEVAQQKSLAQADAEKQKEEAEREARRRGKA---EEQ---AVRQRELAEQELEKQRQLT 1841
Query: 102 ---AQKLKEYEVKIISLSKEKEQLSKQRE--------------AATQEANMWRSELGKAR 144
AQ+ E ++I L E EQ QR+ AATQ+ +EL K R
Sbjct: 1842 EGTAQQRLAAEQELIRLRAETEQGEHQRQLLEEELARLQHEATAATQKRQELEAELAKVR 1901
Query: 145 ESGVILEGALARAEEKVRVAEANAEAKIKEAVQGESAAVSEKQELLAYVDKLKAQLQRQH 204
+L + ARAEE+ R + K K+ ++ E+ E E A + L A+ R+H
Sbjct: 1902 AEMEVLLASKARAEEESR----STSEKSKQRLEAEAGRFRELAEEAARLRAL-AEEARRH 1956
Query: 205 IDSTE 209
+ E
Sbjct: 1957 RELAE 1961
Score = 43.1 bits (100), Expect = 9e-04
Identities = 45/183 (24%), Positives = 83/183 (44%), Gaps = 14/183 (7%)
Query: 37 ELQNFARDLRTRDSTIRDI---AEKLSETAEAAEAAASAAHTIDEQWRNACEEIESLKKD 93
E +N A LR +D+T R + AEK+ + AE A + AA + A E++ +
Sbjct: 2388 EAENRALILRDKDNTQRFLEEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2447
Query: 94 SEKQLELSAQKLKEYEVKIISLSKEKEQLSKQREAATQEANMWRSELGKARESGVILEGA 153
+EK L+ Q ++E L E E L +Q+E A ++A +++ + + V
Sbjct: 2448 AEKMLKEKMQAVQE----ATRLKAEAELLQQQKELAQEQARRLQADKEQMAQQLVEETQG 2503
Query: 154 LARA--EEKVRVAEANAEA-----KIKEAVQGESAAVSEKQELLAYVDKLKAQLQRQHID 206
R E+ R E +AEA ++ E + ++ A + Q +++ +L R +
Sbjct: 2504 FQRTLEAERQRQLEMSAEAERLKLRMAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2563
Query: 207 STE 209
+ E
Sbjct: 2564 TQE 2566
Score = 38.1 bits (87), Expect = 0.027
Identities = 54/268 (20%), Positives = 105/268 (39%), Gaps = 34/268 (12%)
Query: 34 KDEELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASAAHTIDEQWRNACEEIESLKKD 93
++EELQ + + +R AE AE AE A A Q R EE E LK+
Sbjct: 2201 REEELQQTLQQEQNMLERLRSEAEAARRAAEEAEEAREQAEREAAQSRKQVEEAERLKQS 2260
Query: 94 SEKQLELSAQKLKEYEVKIISLSKEKEQLSKQREAATQEANMWRSELGKARESGVILEGA 153
+E+Q + AQ E K R+ A QEA AR
Sbjct: 2261 AEEQAQAQAQAQAAAE--------------KLRKEAEQEA---------ARR-------- 2289
Query: 154 LARAEEKVRVAEANAEAKIKEAVQGESAAVSEKQELLAYVDKLKAQLQRQHIDSTEVFEK 213
A+AE+ + A+A++++ + + +K ++ + L+ QL+ + + E+
Sbjct: 2290 -AQAEQAALKQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKSILDEE 2348
Query: 214 TESC-SDTKHVDLTEENVDKACLSVSRSVPDPAAAECVVQMPTDQVIIQPVGDNEWSDIQ 272
+ ++ V++ SV + + + ++ +I++ DN ++
Sbjct: 2349 LQRLKAEVTEAARQRSQVEEELFSVRVQMEELGKLKARIEAENRALILRD-KDNTQRFLE 2407
Query: 273 ATEARVADVREVASESEVSSLDIPVISQ 300
++ V E A+ V++ + + Q
Sbjct: 2408 EEAEKMKQVAEEAARLSVAAQEAARLRQ 2435
Score = 37.0 bits (84), Expect = 0.061
Identities = 43/197 (21%), Positives = 77/197 (38%), Gaps = 23/197 (11%)
Query: 44 DLRTRDSTIRDIAEK----LSETAEAAEAAASAAHTIDEQWRNACEEIESLKKDSEKQLE 99
DLRTR S + + + +SET E A + R E+E+ + + E
Sbjct: 1458 DLRTRYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAE 1517
Query: 100 LSAQKLKEYEVKIISLSKEKEQLSKQREAATQEANMWR----SELGKARESG-------- 147
AQ + E++ L + ++ +RE A +A + EL R+S
Sbjct: 1518 AHAQAKAQAELEARELQRRMQEEVTRREEAAVDAQQQKRSIQEELQHLRQSSEAEIQAKA 1577
Query: 148 ---VILEGALARAEEKVRVAEANAEAKIKEAVQGESAAVSEKQELLAYVDKLKAQLQRQH 204
E + R EE++RV E ++ A E Q L A ++ +AQ ++
Sbjct: 1578 QQVEAAERSRMRIEEEIRVVRLQLETTERQ----RGGAEDELQALRARAEEAEAQKRQAQ 1633
Query: 205 IDSTEVFEKTESCSDTK 221
++ + + + S K
Sbjct: 1634 EEAERLRRQVQDESQRK 1650
>PLE1_HUMAN (Q15149) Plectin 1 (PLTN) (PCN) (Hemidesmosomal protein 1)
(HD1)
Length = 4684
Score = 49.7 bits (117), Expect = 9e-06
Identities = 53/217 (24%), Positives = 93/217 (42%), Gaps = 12/217 (5%)
Query: 23 DLTIMKETLLVKDEELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASAAHTIDEQWRN 82
+L + + K +L+ ++ + +R+ AE+ ++ AE A A E+W+
Sbjct: 1714 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERQLERWQL 1773
Query: 83 ACEEI--------ESLKKDSEKQLELSAQKLKEYEVKIISLSKEKEQLSKQREAATQEAN 134
E E L++ S Q E QK +E E + K +EQ +QRE A QE
Sbjct: 1774 KANEALRLRLQAEEVLQQKSLAQAEAEKQK-EEAEREARRRGKAEEQAVRQRELAEQELE 1832
Query: 135 MWRSELGKARESGVILEGALARAEEKVRVAEANAEAKIKE--AVQGESAAVSEK-QELLA 191
R + + E L R + E + +E +Q E+AA ++K QEL A
Sbjct: 1833 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1892
Query: 192 YVDKLKAQLQRQHIDSTEVFEKTESCSDTKHVDLTEE 228
+ K++A+++ + E++ S S+ L E
Sbjct: 1893 ELAKVRAEMEVLLASKAKAEEESRSTSEKSKQRLEAE 1929
Score = 44.7 bits (104), Expect = 3e-04
Identities = 48/199 (24%), Positives = 94/199 (47%), Gaps = 19/199 (9%)
Query: 21 MDDLTIMKETLLVKDEELQNFARDLRTRDST---IRDIAEKLSETAEAAEAAASAAHTID 77
M++L+ +K + E +N A LR +D+T +++ AEK+ + AE A + AA
Sbjct: 2374 MEELSKLKARI-----EAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA 2428
Query: 78 EQWRNACEEIESLKKDSEKQLELSAQKLKEYEVKIISLSKEKEQLSKQREAATQEANMWR 137
+ A E++ + +EK L+ Q ++E L E E L +Q+E A ++A +
Sbjct: 2429 RLRQLAEEDLAQQRALAEKMLKEKMQAVQE----ATRLKAEAELLQQQKELAQEQARRLQ 2484
Query: 138 SELGK-ARESGVILEGALARAE-EKVRVAEANAEA-----KIKEAVQGESAAVSEKQELL 190
+ + A++ +G E E+ R E +AEA ++ E + ++ A + Q
Sbjct: 2485 EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR 2544
Query: 191 AYVDKLKAQLQRQHIDSTE 209
+++ +L R + + E
Sbjct: 2545 KQAEEIGEKLHRTELATQE 2563
Score = 43.5 bits (101), Expect = 7e-04
Identities = 50/179 (27%), Positives = 79/179 (43%), Gaps = 27/179 (15%)
Query: 42 ARDLRTRDSTIRDIAEKLSETAEAAEAAASAAHTIDEQWRNACEEIESLKKDSEKQLELS 101
A ++ + S + AEK E AE A +EQ A + E +++ EKQ +L+
Sbjct: 1785 AEEVLQQKSLAQAEAEKQKEEAEREARRRGKA---EEQ---AVRQRELAEQELEKQRQLA 1838
Query: 102 ---AQKLKEYEVKIISLSKEKEQLSKQR--------------EAATQEANMWRSELGKAR 144
AQ+ E ++I L E EQ +QR AATQ+ +EL K R
Sbjct: 1839 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR 1898
Query: 145 ESGVILEGALARAEEKVRVAEANAEAKIKEAVQGESAAVSEKQELLAYVDKLKAQLQRQ 203
+L + A+AEE+ R + K K+ ++ E+ E E A + L + +RQ
Sbjct: 1899 AEMEVLLASKAKAEEESR----STSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1953
Score = 41.6 bits (96), Expect = 0.002
Identities = 50/262 (19%), Positives = 112/262 (42%), Gaps = 21/262 (8%)
Query: 35 DEELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASAAHTIDEQWRNACEEIESLKKDS 94
+EEL R+ +++ +L++ E ++ +E+ R+ E+ S
Sbjct: 1870 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAKAEEESRSTSEK-------S 1922
Query: 95 EKQLELSAQKLKEYEVKIISLSKEKEQLSKQREAATQEANMWRSELGK--ARESGVILEG 152
+++LE A + +E + L E+ +QR+ A ++A R+E + A + I E
Sbjct: 1923 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1982
Query: 153 ALARAEEKVRVAEANAE-AKIKEAVQGESAAVSEKQELLAY----VDKLKAQLQRQHIDS 207
+ E ++ + E AE +++ + E+ +E A +++ AQL++
Sbjct: 1983 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK--ASD 2040
Query: 208 TEVFEKTESCSDTKHVDLTEENVDKACLSVSRSVPDPAAAECVVQMPTDQVIIQPVGDNE 267
+E+ + DT V++ L++ S AA + +++ + I+ ++
Sbjct: 2041 SELERQKGLVEDTLR---QRRQVEEEILALKASFEKAAAGKAELELELGR--IRSNAEDT 2095
Query: 268 WSDIQATEARVADVREVASESE 289
+ E A R++A+E E
Sbjct: 2096 LRSKEQAELEAARQRQLAAEEE 2117
Score = 37.7 bits (86), Expect = 0.036
Identities = 47/218 (21%), Positives = 95/218 (43%), Gaps = 57/218 (26%)
Query: 53 RDIAEKLSET-----------AEAAEAAASAAHTIDEQ---------------------- 79
R I E+L + A AEAA + I+E+
Sbjct: 1553 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1612
Query: 80 --WRNACEEIESLKKDSE-------KQLELSAQKLKEYEVKIISLSKEKEQLSKQREAAT 130
R EE E+ K+ ++ +Q++ +Q+ ++ EV++ S K + + +++++ A
Sbjct: 1613 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1672
Query: 131 Q----------EANMW--RSELGKARESGVILEGALARAEEKV---RVAEANAEAKIKEA 175
Q EA W ++E+ +AR+ V LE A AE ++ R + A A+++ +
Sbjct: 1673 QALEELRLQAEEAERWLCQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1732
Query: 176 VQGESAAVSEKQELLAYVDKLKAQLQRQHIDSTEVFEK 213
+Q E AV++ +E + +A+ +R ++ E+
Sbjct: 1733 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERQLER 1770
Score = 37.0 bits (84), Expect = 0.061
Identities = 46/199 (23%), Positives = 89/199 (44%), Gaps = 15/199 (7%)
Query: 25 TIMKETLLVKDEELQNFARDLRTRDSTI---RDIAEKLSETAEAAEAAASAAHTIDEQWR 81
T+ +E LL + + LQ L +DS + R I ++ ++ + + + A + E+ +
Sbjct: 2615 TVQQEQLLQETQALQQSF--LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2672
Query: 82 NACEEIESLKKDSEKQLELSAQKLKEYEVKIISLSKEKEQLSKQREAATQEANMWRSELG 141
+++E ++ +E + ++ E E + +E +QL +QR Q+ + E
Sbjct: 2673 RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR---QQEELLAEENQ 2729
Query: 142 KARESGVILE----GALARAEEKV--RVAEANAEAKIKEAVQGESAAVSEKQELLAYVDK 195
+ RE +LE ALA +EE +VA ++A+ G +A + K
Sbjct: 2730 RLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRK 2789
Query: 196 LKAQ-LQRQHIDSTEVFEK 213
+ AQ LQ I S E ++
Sbjct: 2790 VSAQRLQEAGILSAEELQR 2808
Score = 37.0 bits (84), Expect = 0.061
Identities = 47/177 (26%), Positives = 72/177 (40%), Gaps = 20/177 (11%)
Query: 34 KDEELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASAAHTIDEQWRNACEEIESLKKD 93
K++ELQ + ++ +R AE AE AE A A Q R EE E LK+
Sbjct: 2198 KEQELQQTLQQEQSVLDRLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS 2257
Query: 94 SEKQLELSAQKLKEYEVKIISLSKEKEQLSKQREAATQE-ANMWRSELGKARESGVILEG 152
+E+Q + AQ E K R+ A QE A ++E R+ +
Sbjct: 2258 AEEQAQARAQAQAAAE--------------KLRKEAEQEAARRAQAEQAALRQK----QA 2299
Query: 153 ALARAEEKVRVAEANAEAKIKEAVQGESAAVSEKQELLAYVDKLKAQLQRQHIDSTE 209
A A E+ + AE K + Q + + +E + L +LQR ++TE
Sbjct: 2300 ADAEMEKHKKFAEQTLRQK-AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2355
Score = 34.3 bits (77), Expect = 0.40
Identities = 43/197 (21%), Positives = 77/197 (38%), Gaps = 23/197 (11%)
Query: 44 DLRTRDSTIRDIAEK----LSETAEAAEAAASAAHTIDEQWRNACEEIESLKKDSEKQLE 99
DLRT S + + + +SET E A + R E+E+ + + E
Sbjct: 1455 DLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAE 1514
Query: 100 LSAQKLKEYEVKIISLSKEKEQLSKQREAATQEANMWR----SELGKARES--------- 146
AQ + E + L + ++ +RE A +A + EL + R+S
Sbjct: 1515 AHAQAKAQAEREAKELQQRIQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA 1574
Query: 147 --GVILEGALARAEEKVRVAEANAEAKIKEAVQGESAAVSEKQELLAYVDKLKAQLQRQH 204
E + R EE++RV EA ++ A E Q L A ++ +AQ ++
Sbjct: 1575 RQAEAAERSRLRIEEEIRVVRLQLEATERQ----RGGAEGELQALRARAEEAEAQKRQAQ 1630
Query: 205 IDSTEVFEKTESCSDTK 221
++ + + + S K
Sbjct: 1631 EEAERLRRQVQDESQRK 1647
>MYHB_RAT (Q63862) Myosin heavy chain, smooth muscle isoform (SMMHC)
(Fragments)
Length = 1327
Score = 49.7 bits (117), Expect = 9e-06
Identities = 58/281 (20%), Positives = 113/281 (39%), Gaps = 40/281 (14%)
Query: 13 TNKTTDGPMDDLTIMKETLLVKDEELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASA 72
TNK M+DL K+ + EL+ R L T+ +R E+L + +A E
Sbjct: 860 TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMRTQLEELEDELQATE----- 914
Query: 73 AHTIDEQWRNACEEIESLKKDSEKQLELSAQKLK-EYEVKIISLSKEKEQLSKQREAATQ 131
D++ +LE++ Q LK ++E L EQ ++R +
Sbjct: 915 --------------------DAKLRLEVNMQALKGQFE---RDLQARDEQNEEKRRQLQR 951
Query: 132 EANMWRSELGKARESGVILEGALARAEEKVRVAEANAEAKIKEAVQGESAAVSEKQELLA 191
+ + + +EL R+ + A + E ++ E A++ AV+G A+ + ++L A
Sbjct: 952 QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS----AVKGREEAIKQLRKLQA 1007
Query: 192 YVDKLKAQLQRQHIDSTEVF---EKTESCSDTKHVDLTEENVDKACLSVSRSVPDPAAAE 248
+ + +L E+F ++ E + + +L + D A +R D E
Sbjct: 1008 QMKDFQRELDDARASRDEIFATSKENEKKAKSLEAELMQLQEDLAAAERARKQADLEKEE 1067
Query: 249 CVVQMPTDQVIIQPVGDNEWSDIQATEARVADVREVASESE 289
++ + + D + + EAR+A + E E +
Sbjct: 1068 LAEELASSLSGRNTLQDEK----RRLEARIAQLEEELEEEQ 1104
Score = 39.7 bits (91), Expect = 0.009
Identities = 43/226 (19%), Positives = 93/226 (41%), Gaps = 10/226 (4%)
Query: 6 RNTLGMMTNKTTDGPMDDLTIMKETLLVKDEELQNFARDLRTRDSTIRDIAEKLSETAEA 65
+ L K +G + DL + ++ + EE + LR + ++D +L + +
Sbjct: 966 QRALAAAAKKKLEGDLKDLELQADSAVKGREEA---IKQLRKLQAQMKDFQRELDDARAS 1022
Query: 66 AEAAASAAHTIDEQWRNACEEIESLKKDSEKQLELSAQKLKEYEVKIISLSKEKEQLSKQ 125
+ + + +++ ++ E+ L++D L + + K+ +++ L++E
Sbjct: 1023 RDEIFATSKENEKKAKSLEAELMQLQED----LAAAERARKQADLEKEELAEELASSLSG 1078
Query: 126 REAATQEANMWRSELGKARESGVILEGALARAEEKVRVAEANAEAKIKEAVQGESAA--- 182
R E + + + E +G + ++VR A AE E V SAA
Sbjct: 1079 RNTLQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATLQAEQLSNELVTERSAAQKN 1138
Query: 183 VSEKQELLAYVDKLKAQLQRQHIDSTEVFEKTESCSDTKHVDLTEE 228
S +Q+L +L+++LQ + T + + K V L E+
Sbjct: 1139 ESARQQLERQNKELRSKLQEVEGAVKAKLKSTVAALEAKIVQLEEQ 1184
Score = 38.1 bits (87), Expect = 0.027
Identities = 41/168 (24%), Positives = 79/168 (46%), Gaps = 8/168 (4%)
Query: 35 DEELQNF-ARDLRTRDSTIRDIAEKLSETAEAAEAAASAAHTIDEQWRNACEEIESLKKD 93
+EE N A R R +T++ AE+LS +AA + +Q +E+ S ++
Sbjct: 1101 EEEQGNMEAMSDRVRKATLQ--AEQLSNELVTERSAAQKNESARQQLERQNKELRSKLQE 1158
Query: 94 SEKQLELSAQK-LKEYEVKIISLSKEKEQLSKQREAATQEANMWRSELGKARESGVILEG 152
E ++ + + E KI+ L ++ EQ +++++AAT+ + + + K +E + +E
Sbjct: 1159 VEGAVKAKLKSTVAALEAKIVQLEEQIEQEAREKQAATK---LLKQKDKKLKEVLLQVED 1215
Query: 153 ALARAEEKVRVAEANAEAKIKEAVQGESAAVSEKQELLAYVDKLKAQL 200
E+ AE K+K+ + A E Q + A KL+ +L
Sbjct: 1216 ERKMVEQYKEQAE-KGNTKVKQLKRQLEEAEEESQRINANRRKLQREL 1262
Score = 36.6 bits (83), Expect = 0.080
Identities = 23/115 (20%), Positives = 53/115 (46%), Gaps = 4/115 (3%)
Query: 35 DEELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASAAHTIDEQWRNACEEIESLKKDS 94
+E+++ AR+ + ++ +KL E E EQ++ E+ + K
Sbjct: 1182 EEQIEQEAREKQAATKLLKQKDKKLKEVLLQVEDERKMV----EQYKEQAEKGNTKVKQL 1237
Query: 95 EKQLELSAQKLKEYEVKIISLSKEKEQLSKQREAATQEANMWRSELGKARESGVI 149
++QLE + ++ + L +E ++ ++ EA +E N +S+L + E+ +
Sbjct: 1238 KRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNEASFV 1292
Score = 35.0 bits (79), Expect = 0.23
Identities = 42/195 (21%), Positives = 94/195 (47%), Gaps = 20/195 (10%)
Query: 27 MKETLLVKDEELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASAAHTIDEQWRNACEE 86
++ L+ E+L R + D ++AE+L+ ++ S +T+ ++ R
Sbjct: 1040 LEAELMQLQEDLAAAERARKQADLEKEELAEELA-------SSLSGRNTLQDEKRRLEAR 1092
Query: 87 IESLKKDSEKQ---LELSAQKLKEYEVKIISLSKE---KEQLSKQREAATQEANMWRSEL 140
I L+++ E++ +E + ++++ ++ LS E + +++ E+A Q+ EL
Sbjct: 1093 IAQLEEELEEEQGNMEAMSDRVRKATLQAEQLSNELVTERSAAQKNESARQQLERQNKEL 1152
Query: 141 -GKARESGVILEGALARAEEKVRVAEANAE-AKIKEAVQGESAAVSEKQELLAYVDKLKA 198
K +E +EGA+ +A+ K VA A+ +++E ++ E+ +LL DK
Sbjct: 1153 RSKLQE----VEGAV-KAKLKSTVAALEAKIVQLEEQIEQEAREKQAATKLLKQKDKKLK 1207
Query: 199 QLQRQHIDSTEVFEK 213
++ Q D ++ E+
Sbjct: 1208 EVLLQVEDERKMVEQ 1222
>GOB1_HUMAN (Q14789) Golgi autoantigen, golgin subfamily B member 1
(Giantin) (Macrogolgin) (Golgi complex-associated
protein, 372-kDa) (GCP372)
Length = 3259
Score = 49.7 bits (117), Expect = 9e-06
Identities = 47/240 (19%), Positives = 105/240 (43%), Gaps = 14/240 (5%)
Query: 23 DLTIMKETLLVKDEELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASAAHTIDEQWRN 82
++ +K + + + E Q ++L+ + E +S AE + A ++
Sbjct: 1589 EIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYG 1648
Query: 83 ACEEIESLKKDSEKQLELSAQKLKEYEVKIISLSKEKEQLSKQREAATQEANMWRSELGK 142
E+ KK++EKQL+ + Q+++E + K+ +K K+Q + E +E + R+E+
Sbjct: 1649 KLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELE---EENDRLRAEVHP 1705
Query: 143 ARESGVILEGALARAEEKVRVAEANAEAKIKEAVQGESAAVSEKQELLAYVDKLKAQLQ- 201
A ++ L + ++ + + + + + +SEK L V LK Q++
Sbjct: 1706 AGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIED 1765
Query: 202 ----RQHIDSTEVFEKTESCSDTKHVDLTEENVDKACLSV------SRSVPDPAAAECVV 251
+ ++++TE + + ++ + E ++ LS+ S SVP +A V
Sbjct: 1766 NVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAV 1825
Score = 40.4 bits (93), Expect = 0.006
Identities = 72/329 (21%), Positives = 121/329 (35%), Gaps = 35/329 (10%)
Query: 6 RNTLGMMTNKTTDGPMDDLTIMKETLLVKDEELQNFARDLRTRDSTIRDIAEKLSET--- 62
R T+ +T D KE KD L A RD I ++ L E
Sbjct: 1510 RGTIERLTKSLADVESQVSAQNKE----KDTVLGRLALLQEERDKLITEMDRSLLENQSL 1565
Query: 63 AEAAEAAASAAHTIDEQWRNACEEIESLKK----DSEKQLELSAQKLKEYEVKIIS---L 115
+ + E+ A + E +EIESLK +S + E + KEYE+ + S +
Sbjct: 1566 SSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENV 1625
Query: 116 SKEKEQLSKQREAATQEANMWRSELGKARESGVILEGALARAE-------EKVRVAEANA 168
S E E++ EA QE +L + E L AE EK+R +
Sbjct: 1626 SNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSK 1685
Query: 169 EAKIKEAVQGESAAVSE-----------KQELLAYVDKLKAQLQRQHIDSTEVFEKTESC 217
+ KI E + +E + LL+ +K +L+R ++ + +K +S
Sbjct: 1686 QQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSL 1745
Query: 218 SDTKHVDLTEENVDKACLSVSRSVPDPAAAECVVQMPTDQVIIQPVGDNEWSDIQATEAR 277
K D E V + +V A E + + + + + + ++
Sbjct: 1746 MSEK--DSLSEEVQDLKHQIEDNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSL 1803
Query: 278 VADVREVASESEVSSLDI-PVISQQGTNH 305
R SES S+ P +S+ ++H
Sbjct: 1804 SMSTRPTCSESVPSAKSANPAVSKDFSSH 1832
Score = 39.3 bits (90), Expect = 0.012
Identities = 52/218 (23%), Positives = 99/218 (44%), Gaps = 33/218 (15%)
Query: 28 KETLL----VKDEELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASAAHTIDEQWRNA 83
K TLL KD EL+ ++ + + I E+LS + E A ++E+ N
Sbjct: 1870 KNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQ 1929
Query: 84 CEEIESL-------KKDSEKQLELSAQKLKEYEVKIISLSKEKEQLSKQREAATQEANMW 136
E+ D++ + EL ++K + + L +EK+QL K++ E+ +
Sbjct: 1930 LAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKV--ESEIR 1987
Query: 137 RSELGKARESGVILEGALARAEEKVRVAEANAEAKIKEAVQGESAAVSEKQ-ELLAYVDK 195
+ L K ++GA K E ++E ++ + V + Q + + Y +K
Sbjct: 1988 KEYLEK-------IQGAQKEPGNKSHAKE------LQELLKEKQQEVKQLQKDCIRYQEK 2034
Query: 196 LKAQLQRQHIDSTEVFEKTESCSDTKHVDLTEENVDKA 233
+ A L+R + + E F +TES K +++T+EN+ +A
Sbjct: 2035 ISA-LERT-VKALE-FVQTES---QKDLEITKENLAQA 2066
Score = 38.9 bits (89), Expect = 0.016
Identities = 45/198 (22%), Positives = 91/198 (45%), Gaps = 31/198 (15%)
Query: 27 MKETLLVKDEELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASAAHT-IDEQWRNACE 85
+++ + K+E++ + L +++ + I ++ E E A HT ++ Q + E
Sbjct: 1397 LQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQ----EDLIKALHTQLEMQAKEHDE 1452
Query: 86 EIESLKKDSEKQLELSAQKLKEYEVKIISLSKEKEQLSKQ-------REAATQEANMWRS 138
I KQL++ ++K+ +I S+ K+Q+ ++ R+ A +E +
Sbjct: 1453 RI--------KQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQE 1504
Query: 139 ELGKARESGVILEGALARAEEKVRVAEANAEAKIKEAVQGESAAVSEKQELLAYVDKLKA 198
EL AR + L +LA E +V +A+ K K+ V G A + E++ DKL
Sbjct: 1505 ELSLARGTIERLTKSLADVESQV-----SAQNKEKDTVLGRLALLQEER------DKLIT 1553
Query: 199 QLQRQHIDSTEVFEKTES 216
++ R +++ + ES
Sbjct: 1554 EMDRSLLENQSLSSSCES 1571
Score = 38.9 bits (89), Expect = 0.016
Identities = 47/197 (23%), Positives = 89/197 (44%), Gaps = 37/197 (18%)
Query: 27 MKETLLVKDEE----LQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASAAHTIDEQWRN 82
+ + + +KD + L+ + + ++ + EKL E+ EA E + + + E+ ++
Sbjct: 2540 LNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQD 2599
Query: 83 ACEEIESLKKDSEKQLELSAQKLKEYEVKIISLSKEKEQLSKQREAATQEANMWRSELGK 142
+EIESLK +S+S+ Q++ +E T ++ ++L K
Sbjct: 2600 LSKEIESLK---------------------VSISQLTRQVTALQEEGT--LGLYHAQL-K 2635
Query: 143 ARESGVILEGALARAEEKVRVAEANAEAKIKEAVQGESAAVSEKQELLAYVDKLKAQLQR 202
+E V AL + +K R+AE E VQ E+A + E DKLK +L+
Sbjct: 2636 VKEEEVHRLSALFSSSQK-RIAELEEEL---VCVQKEAAKKVGEIE-----DKLKKELKH 2686
Query: 203 QHIDSTEVFEKTESCSD 219
H D+ + +TE+ +
Sbjct: 2687 LHHDAGIMRNETETAEE 2703
Score = 38.1 bits (87), Expect = 0.027
Identities = 39/179 (21%), Positives = 79/179 (43%), Gaps = 9/179 (5%)
Query: 23 DLTIMKETLLVKDEELQNFARDLRTRDSTIRDIA----EKLSETAEAAEAAASAAHTIDE 78
++T M + LL K +++ + + +D + +I+ EK+ + E + T+ E
Sbjct: 874 EITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKE 933
Query: 79 QWRNACEEIESLKKDSEKQLELSAQKLKEYEVKIISLSKEKEQLSKQREAATQEANMWRS 138
Q E+ K+ E+ E+S+ + Y+ + KE+L + + +E +
Sbjct: 934 QLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKR 993
Query: 139 ELGKARESGVILEGALARAEEKVR--VAEANAEAKIKEAVQGESAAVSEKQELLAYVDK 195
+L A + L ++R EE++ E+ E + E +GE V E +E Y +K
Sbjct: 994 KLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGE---VEEDKENKEYSEK 1049
Score = 35.8 bits (81), Expect = 0.14
Identities = 44/220 (20%), Positives = 87/220 (39%), Gaps = 34/220 (15%)
Query: 14 NKTTDGPMDDLTIMKETLLVKDEELQNFARDLRTRDSTIRDIA----------------- 56
N T + + L + + LL KDE+L + + L + ++ +
Sbjct: 2793 NSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNEL 2852
Query: 57 EKLSETAEAAEAAASAAHTIDEQWRNACEEIESLKKDSE---KQLELSAQKLKEYEVKII 113
EK ++ E + +A+ T + ++ + + SL+ D + K+L+ Q+ + +I
Sbjct: 2853 EKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEIT 2912
Query: 114 SLSKEKEQLSK----------QREAATQEANMWRSELGKARESGVILEGALARAEEKVRV 163
L K QL + +E QE W+ EL + R E R +E+ +
Sbjct: 2913 ELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLM 2972
Query: 164 AEANAEAKIKEAVQGESAAVSEKQELLAYVDKLKAQLQRQ 203
A ++ + ++ + E + + LK Q QRQ
Sbjct: 2973 AISDKDQQLSHL----QNLIRELRSSSSQTQPLKVQYQRQ 3008
Score = 33.1 bits (74), Expect = 0.88
Identities = 49/214 (22%), Positives = 95/214 (43%), Gaps = 35/214 (16%)
Query: 27 MKETLLVKDEELQNFARDLRTR---DSTIRDIAEKLSET------------AEAAEAAAS 71
+K+T+ K+ ELQ+ +DL + + + + +++++T AE +E A
Sbjct: 1062 LKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAI 1121
Query: 72 AAHTIDEQWRNACEEIESLKKDS---EKQLELSAQKLK-EYEVKIISLSKEKEQLSKQ-R 126
I + + +L K++ S++ K E E KI++L KEKEQL K+ +
Sbjct: 1122 IQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQ 1181
Query: 127 EAATQEANMWRSELGKARESGVILEGALARAEEKVRVAEANAEAKIKEAVQGESAAVSEK 186
EA T ++ L KA+E L L + ++ +++E +S E
Sbjct: 1182 EALTSR----KAILKKAQEKERHLREELKQQKDDYN--------RLQEQFDEQS---KEN 1226
Query: 187 QELLAYVDKLKAQLQRQHIDSTEVFEKTESCSDT 220
+ + + +L+ Q++ ++ ESCS T
Sbjct: 1227 ENIGDQLRQLQIQVRESIDGKLPSTDQQESCSST 1260
Score = 33.1 bits (74), Expect = 0.88
Identities = 44/229 (19%), Positives = 96/229 (41%), Gaps = 26/229 (11%)
Query: 22 DDLTIMKETLLVKDEELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASAAHTIDEQWR 81
D + +E + +K++ LR + ++ +S + S A T + +
Sbjct: 2217 DAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQ 2276
Query: 82 NACEEIESLKKDSEKQLELSAQKLKEYEVKIISLSKEKEQLSKQREAATQEANMWRSELG 141
C+ ++ K+ QLE + Y L+K + +L ++ T +N L
Sbjct: 2277 KVCDTLQGENKELLSQLE---ETRHLYHSSQNELAKLESELKSLKDQLTDLSN----SLE 2329
Query: 142 KARESGVILEGALARAEEKVRVAEANAEAKIKEAVQGESAAVS--------EKQELLAYV 193
K +E LEG + + E ++ ++ + E +++ +Q S ++Q++++ +
Sbjct: 2330 KCKEQKGNLEGIIRQQEADIQNSKFSYE-QLETDLQASRELTSRLHEEINMKEQKIISLL 2388
Query: 194 DKLK-------AQLQRQHIDSTEVFEKTESCSDTKHVDLTEEN---VDK 232
+ A+L++QH + E S + +++ L EEN VDK
Sbjct: 2389 SGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDK 2437
Score = 30.0 bits (66), Expect = 7.5
Identities = 20/52 (38%), Positives = 28/52 (53%), Gaps = 4/52 (7%)
Query: 114 SLSKEKEQLSKQREAATQEANMWRSELGKARESGVILEGALARAEEKVRVAE 165
S S+ ++QL R QE N R L + R+ V E AL+ AEE++R E
Sbjct: 3135 SFSEAQQQLCNTR----QEVNELRKLLEEERDQRVAAENALSVAEEQIRRLE 3182
>TPM1_RAT (P04692) Tropomyosin 1 alpha chain (Alpha-tropomyosin)
Length = 284
Score = 49.3 bits (116), Expect = 1e-05
Identities = 52/216 (24%), Positives = 96/216 (44%), Gaps = 19/216 (8%)
Query: 22 DDLTIMKETLLVKDEELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASAA-HTIDEQW 80
D+L +++ L ++EL ++ L+ + ++AEK + AEA A+ + ++E+
Sbjct: 41 DELVSLQKKLKGTEDELDKYSEALKDAQEKL-ELAEKKATDAEADVASLNRRIQLVEEEL 99
Query: 81 RNA----------CEEIESLKKDSE---KQLELSAQKLKE-YEVKIISLSKEK---EQLS 123
A EE E +SE K +E AQK +E E++ I L + K E
Sbjct: 100 DRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDAD 159
Query: 124 KQREAATQEANMWRSELGKARESGVILEGALARAEEKVRVAEANAEAKIKEAVQGESAAV 183
++ E ++ + S+L +A E + EG A EE+++ N ++ +A +
Sbjct: 160 RKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKED 219
Query: 184 SEKQELLAYVDKLKAQLQRQHIDSTEVFEKTESCSD 219
++E+ DKLK R V + +S D
Sbjct: 220 KYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDD 255
Score = 38.9 bits (89), Expect = 0.016
Identities = 44/179 (24%), Positives = 71/179 (39%), Gaps = 14/179 (7%)
Query: 30 TLLVKDEELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASAAHTIDEQWRNACEE--- 86
T L K EE + A + I A+K E E E A I E EE
Sbjct: 108 TALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVAR 167
Query: 87 ----IESLKKDSEKQLELSAQKLKEYEVKIISLSKEKEQLSKQREAATQEANMWRSELGK 142
IES + +E++ ELS K E E ++ +++ + L Q E +Q+ + + E+
Sbjct: 168 KLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDKYEEEI-- 225
Query: 143 ARESGVILEGALARAEEKVRVAEANAEAKIKEAVQGESAAVSEKQELLAYVDKLKAQLQ 201
+L L AE + AE + K E ++K + A ++L L+
Sbjct: 226 -----KVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALK 279
Score = 37.7 bits (86), Expect = 0.036
Identities = 38/182 (20%), Positives = 80/182 (43%), Gaps = 11/182 (6%)
Query: 57 EKLSETAEAAEAAASAAHTIDEQWRNACEEIESLKKDSEKQLELSAQKLKEYEVKIISLS 116
E + AE AEA AA +Q + ++ K +E +L+ ++ LK+ + K+
Sbjct: 16 ENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALKDAQEKLELAE 75
Query: 117 K-------EKEQLSKQREAATQEANMWRSELGKARESGVILEGALARAEEKVRVAEANAE 169
K + L+++ + +E + + L A + E A +E ++V E+ A+
Sbjct: 76 KKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQ 135
Query: 170 AKIKEAVQGESAAVSEKQELLAYVDKLKAQLQRQHI---DSTEVFEKTESCSDTKHVDLT 226
K +E ++ + + E + + D+ ++ R+ + E E+ S+ K +L
Sbjct: 136 -KDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELE 194
Query: 227 EE 228
EE
Sbjct: 195 EE 196
>TPM1_RABIT (P58772) Tropomyosin 1 alpha chain (Alpha-tropomyosin)
Length = 284
Score = 49.3 bits (116), Expect = 1e-05
Identities = 52/216 (24%), Positives = 96/216 (44%), Gaps = 19/216 (8%)
Query: 22 DDLTIMKETLLVKDEELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASAA-HTIDEQW 80
D+L +++ L ++EL ++ L+ + ++AEK + AEA A+ + ++E+
Sbjct: 41 DELVSLQKKLKGTEDELDKYSEALKDAQEKL-ELAEKKATDAEADVASLNRRIQLVEEEL 99
Query: 81 RNA----------CEEIESLKKDSE---KQLELSAQKLKE-YEVKIISLSKEK---EQLS 123
A EE E +SE K +E AQK +E E++ I L + K E
Sbjct: 100 DRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDAD 159
Query: 124 KQREAATQEANMWRSELGKARESGVILEGALARAEEKVRVAEANAEAKIKEAVQGESAAV 183
++ E ++ + S+L +A E + EG A EE+++ N ++ +A +
Sbjct: 160 RKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKED 219
Query: 184 SEKQELLAYVDKLKAQLQRQHIDSTEVFEKTESCSD 219
++E+ DKLK R V + +S D
Sbjct: 220 KYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDD 255
Score = 38.5 bits (88), Expect = 0.021
Identities = 43/174 (24%), Positives = 69/174 (38%), Gaps = 14/174 (8%)
Query: 30 TLLVKDEELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASAAHTIDEQWRNACEE--- 86
T L K EE + A + I A+K E E E A I E EE
Sbjct: 108 TALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVAR 167
Query: 87 ----IESLKKDSEKQLELSAQKLKEYEVKIISLSKEKEQLSKQREAATQEANMWRSELGK 142
IES + +E++ ELS K E E ++ +++ + L Q E +Q+ + + E+
Sbjct: 168 KLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDKYEEEI-- 225
Query: 143 ARESGVILEGALARAEEKVRVAEANAEAKIKEAVQGESAAVSEKQELLAYVDKL 196
+L L AE + AE + K E ++K + A ++L
Sbjct: 226 -----KVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEEL 274
Score = 37.7 bits (86), Expect = 0.036
Identities = 38/182 (20%), Positives = 80/182 (43%), Gaps = 11/182 (6%)
Query: 57 EKLSETAEAAEAAASAAHTIDEQWRNACEEIESLKKDSEKQLELSAQKLKEYEVKIISLS 116
E + AE AEA AA +Q + ++ K +E +L+ ++ LK+ + K+
Sbjct: 16 ENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALKDAQEKLELAE 75
Query: 117 K-------EKEQLSKQREAATQEANMWRSELGKARESGVILEGALARAEEKVRVAEANAE 169
K + L+++ + +E + + L A + E A +E ++V E+ A+
Sbjct: 76 KKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQ 135
Query: 170 AKIKEAVQGESAAVSEKQELLAYVDKLKAQLQRQHI---DSTEVFEKTESCSDTKHVDLT 226
K +E ++ + + E + + D+ ++ R+ + E E+ S+ K +L
Sbjct: 136 -KDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELE 194
Query: 227 EE 228
EE
Sbjct: 195 EE 196
>TPM1_MOUSE (P58771) Tropomyosin 1 alpha chain (Alpha-tropomyosin)
Length = 284
Score = 49.3 bits (116), Expect = 1e-05
Identities = 52/216 (24%), Positives = 96/216 (44%), Gaps = 19/216 (8%)
Query: 22 DDLTIMKETLLVKDEELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASAA-HTIDEQW 80
D+L +++ L ++EL ++ L+ + ++AEK + AEA A+ + ++E+
Sbjct: 41 DELVSLQKKLKGTEDELDKYSEALKDAQEKL-ELAEKKATDAEADVASLNRRIQLVEEEL 99
Query: 81 RNA----------CEEIESLKKDSE---KQLELSAQKLKE-YEVKIISLSKEK---EQLS 123
A EE E +SE K +E AQK +E E++ I L + K E
Sbjct: 100 DRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDAD 159
Query: 124 KQREAATQEANMWRSELGKARESGVILEGALARAEEKVRVAEANAEAKIKEAVQGESAAV 183
++ E ++ + S+L +A E + EG A EE+++ N ++ +A +
Sbjct: 160 RKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKED 219
Query: 184 SEKQELLAYVDKLKAQLQRQHIDSTEVFEKTESCSD 219
++E+ DKLK R V + +S D
Sbjct: 220 KYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDD 255
Score = 38.5 bits (88), Expect = 0.021
Identities = 43/174 (24%), Positives = 69/174 (38%), Gaps = 14/174 (8%)
Query: 30 TLLVKDEELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASAAHTIDEQWRNACEE--- 86
T L K EE + A + I A+K E E E A I E EE
Sbjct: 108 TALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVAR 167
Query: 87 ----IESLKKDSEKQLELSAQKLKEYEVKIISLSKEKEQLSKQREAATQEANMWRSELGK 142
IES + +E++ ELS K E E ++ +++ + L Q E +Q+ + + E+
Sbjct: 168 KLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDKYEEEI-- 225
Query: 143 ARESGVILEGALARAEEKVRVAEANAEAKIKEAVQGESAAVSEKQELLAYVDKL 196
+L L AE + AE + K E ++K + A ++L
Sbjct: 226 -----KVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEEL 274
Score = 37.7 bits (86), Expect = 0.036
Identities = 38/182 (20%), Positives = 80/182 (43%), Gaps = 11/182 (6%)
Query: 57 EKLSETAEAAEAAASAAHTIDEQWRNACEEIESLKKDSEKQLELSAQKLKEYEVKIISLS 116
E + AE AEA AA +Q + ++ K +E +L+ ++ LK+ + K+
Sbjct: 16 ENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALKDAQEKLELAE 75
Query: 117 K-------EKEQLSKQREAATQEANMWRSELGKARESGVILEGALARAEEKVRVAEANAE 169
K + L+++ + +E + + L A + E A +E ++V E+ A+
Sbjct: 76 KKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQ 135
Query: 170 AKIKEAVQGESAAVSEKQELLAYVDKLKAQLQRQHI---DSTEVFEKTESCSDTKHVDLT 226
K +E ++ + + E + + D+ ++ R+ + E E+ S+ K +L
Sbjct: 136 -KDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELE 194
Query: 227 EE 228
EE
Sbjct: 195 EE 196
>MYHB_RABIT (P35748) Myosin heavy chain, smooth muscle isoform (SMMHC)
Length = 1972
Score = 49.3 bits (116), Expect = 1e-05
Identities = 57/281 (20%), Positives = 113/281 (39%), Gaps = 40/281 (14%)
Query: 13 TNKTTDGPMDDLTIMKETLLVKDEELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASA 72
TNK M+DL K+ + EL+ R L T+ ++ E+L + +A E
Sbjct: 1505 TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATE----- 1559
Query: 73 AHTIDEQWRNACEEIESLKKDSEKQLELSAQKLK-EYEVKIISLSKEKEQLSKQREAATQ 131
D++ +LE++ Q LK ++E L EQ ++R +
Sbjct: 1560 --------------------DAKLRLEVNMQALKVQFE---RDLQARDEQNEEKRRQLQR 1596
Query: 132 EANMWRSELGKARESGVILEGALARAEEKVRVAEANAEAKIKEAVQGESAAVSEKQELLA 191
+ + + +EL R+ + A + E ++ E A++ A++G A+ + +L A
Sbjct: 1597 QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS----AIKGREEAIKQLLKLQA 1652
Query: 192 YVDKLKAQLQRQHIDSTEVF---EKTESCSDTKHVDLTEENVDKACLSVSRSVPDPAAAE 248
+ + +L+ E+F ++ E + + DL + D A +R D E
Sbjct: 1653 QMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEE 1712
Query: 249 CVVQMPTDQVIIQPVGDNEWSDIQATEARVADVREVASESE 289
++ + + D + + EAR+A + E E +
Sbjct: 1713 LAEELASSLSGRNALQDEK----RRLEARIAQLEEELEEEQ 1749
Score = 48.9 bits (115), Expect = 2e-05
Identities = 49/194 (25%), Positives = 96/194 (49%), Gaps = 31/194 (15%)
Query: 27 MKETLLVKDEELQNFARDLRTRDST---------IRDIAEKLSETAEAAEAAASAAHTID 77
+K L K+EELQ A R D T IR++ +S+ E ++ +A + +
Sbjct: 1081 LKMQLAKKEEELQ--AALARLEDETSQKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1138
Query: 78 EQWRNACEEIESLKKDSEKQLELSA--QKLKEYEVKIISLSKEKEQLSKQREAATQEANM 135
+Q R+ EE+E+LK + E L+ +A Q+L+ +K +++++ ++A +E
Sbjct: 1139 KQKRDLGEELEALKTELEDTLDTTATQQELR---------AKREQEVTVLKKALDEETRS 1189
Query: 136 WRSELGKARESGVILEGALARAEEKVRVAEANAEAKIKEAVQGESAAVS--------EKQ 187
+++ + R+ + L E+ + A+AN + K K+ ++ E+A ++ KQ
Sbjct: 1190 HEAQVQEMRQKHTQVVEELTEQLEQFKRAKANLD-KTKQTLEKENADLAGELRVLGQAKQ 1248
Query: 188 ELLAYVDKLKAQLQ 201
E+ KL+ QLQ
Sbjct: 1249 EVEHKKKKLEVQLQ 1262
Score = 43.1 bits (100), Expect = 9e-04
Identities = 42/206 (20%), Positives = 91/206 (43%), Gaps = 17/206 (8%)
Query: 27 MKETLLVKDEELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASAAHTIDEQWRNACEE 86
M+ L K +EL+ ++ R D ++L AE A +D + EE
Sbjct: 909 MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ-----AERKKMAQQMLDLE--EQLEE 961
Query: 87 IESLKKDSEKQLELSAQKLKEYEVKIISLSKEKEQLSKQREAATQEANMWRSELGKARES 146
E+ ++ + + + K+K+ E I+ + + +LSK+R+ + + + L + E
Sbjct: 962 EEAARQKLQLEKVTAEAKIKKLEDDILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021
Query: 147 GVIL-------EGALARAEEKVRVAEANAE--AKIKEAVQGESAAVSEK-QELLAYVDKL 196
L E ++ E +++ E + + K+K + GE++ + E+ +L A + +L
Sbjct: 1022 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKMDGEASDLHEQIADLQAQIAEL 1081
Query: 197 KAQLQRQHIDSTEVFEKTESCSDTKH 222
K QL ++ + + E + K+
Sbjct: 1082 KMQLAKKEEELQAALARLEDETSQKN 1107
Score = 38.9 bits (89), Expect = 0.016
Identities = 45/229 (19%), Positives = 96/229 (41%), Gaps = 31/229 (13%)
Query: 27 MKETLLVKDEELQNFARDLRTRDSTIRDIAEKLSETAEAA----------EAAASAAHTI 76
+++ +LV D++ +++ + + I D+ L+E E A E+ S
Sbjct: 983 LEDDILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR 1042
Query: 77 DEQWRNACEEIESLKKDSEKQLELSAQKLKEYEVKI----ISLSKEKEQLSKQREAATQE 132
++ + +E+E LK+ + + +++ + + +I + L+K++E+L E
Sbjct: 1043 LKKEEKSRQELEKLKRKMDGEASDLHEQIADLQAQIAELKMQLAKKEEELQAALARLEDE 1102
Query: 133 ANMWRSELGKARESGVILEGALARAEEKV---RVAEANAEAK----------IKEAVQGE 179
+ + L K RE LEG ++ +E + R A AE + +K ++
Sbjct: 1103 TSQKNNALKKIRE----LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDT 1158
Query: 180 SAAVSEKQELLAYVDKLKAQLQRQHIDSTEVFEKTESCSDTKHVDLTEE 228
+ +QEL A ++ L++ + T E KH + EE
Sbjct: 1159 LDTTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHTQVVEE 1207
Score = 37.4 bits (85), Expect = 0.047
Identities = 24/115 (20%), Positives = 54/115 (46%), Gaps = 4/115 (3%)
Query: 35 DEELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASAAHTIDEQWRNACEEIESLKKDS 94
+E+++ AR+ + ++ +KL E E A EQ++ E+ + K
Sbjct: 1827 EEQVEQEAREKQAAAKALKQRDKKLKEMLLQVEDERKMA----EQYKEQAEKGNAKVKQL 1882
Query: 95 EKQLELSAQKLKEYEVKIISLSKEKEQLSKQREAATQEANMWRSELGKARESGVI 149
++QLE + ++ + L +E ++ ++ EA +E N +S+L + E+ +
Sbjct: 1883 KRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFV 1937
Score = 34.7 bits (78), Expect = 0.30
Identities = 45/223 (20%), Positives = 91/223 (40%), Gaps = 31/223 (13%)
Query: 35 DEELQNFARDLRTRDSTIRDI---AEKLSETAEAAEAAASAAHTIDEQWRNACEEIESLK 91
+EEL+ ++ +R AE+LS + A + +Q +E++S
Sbjct: 1742 EEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELKSKL 1801
Query: 92 KDSEKQLELSAQK-LKEYEVKIISLSKEKEQLSKQREAATQE------------------ 132
++ E ++ + + E KI L ++ EQ +++++AA +
Sbjct: 1802 QEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAAKALKQRDKKLKEMLLQVEDE 1861
Query: 133 ---ANMWRSELGKARESGVILEGALARAEEKVRVAEANAEAKIKEAVQGESAAVSEKQEL 189
A ++ + K L+ L AEE+ + AN + +Q E +E E
Sbjct: 1862 RKMAEQYKEQAEKGNAKVKQLKRQLEEAEEESQRINAN-----RRKLQRELDEATESNEA 1916
Query: 190 LA-YVDKLKAQLQRQHIDSTEVFEKTESCSDTKHVDLTEENVD 231
+ V+ LK++L+R + S ++ ++ D +EE VD
Sbjct: 1917 MGREVNALKSKLRRGNETSFVPTRRSGGRRVIENADGSEEEVD 1959
Score = 32.3 bits (72), Expect = 1.5
Identities = 39/192 (20%), Positives = 87/192 (45%), Gaps = 14/192 (7%)
Query: 27 MKETLLVKDEELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAASAAHTIDEQWRNACEE 86
++ L+ E+L R + D ++AE+L+ + A ++ + EE
Sbjct: 1685 LEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1744
Query: 87 IESLKKDSEKQLELSAQKLKEYEVKIISLSKE---KEQLSKQREAATQEANMWRSEL-GK 142
+E + + +E + ++++ + LS E + +++ E+A Q+ EL K
Sbjct: 1745 LE----EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELKSK 1800
Query: 143 ARESGVILEGALARAEEKVRVAEANAE-AKIKEAVQGESAAVSEKQELLAYVDKLKAQLQ 201
+E +EGA+ +++ K +A A+ A+++E V+ E+ + L DK ++
Sbjct: 1801 LQE----MEGAV-KSKFKSTIAALEAKIAQLEEQVEQEAREKQAAAKALKQRDKKLKEML 1855
Query: 202 RQHIDSTEVFEK 213
Q D ++ E+
Sbjct: 1856 LQVEDERKMAEQ 1867
Score = 31.2 bits (69), Expect = 3.4
Identities = 47/244 (19%), Positives = 104/244 (42%), Gaps = 23/244 (9%)
Query: 23 DLTIMKETLLVKDEELQNFARDLRTRDSTIRDIAEKLSETAEAAEAAAS----AAHTIDE 78
++T++K+ L DEE ++ ++ + E+L+E E + A + T+++
Sbjct: 1175 EVTVLKKAL---DEETRSHEAQVQEMRQKHTQVVEELTEQLEQFKRAKANLDKTKQTLEK 1231
Query: 79 QWRN----------ACEEIESLKKDSEKQLELSAQKLKEYEVKIISLSKEKEQLSKQREA 128
+ + A +E+E KK E QL+ K + E L+ + +L + E+
Sbjct: 1232 ENADLAGELRVLGQAKQEVEHKKKKLEVQLQELQSKCSDGERARAELNDKVHKLQNEVES 1291
Query: 129 AT---QEANMWRSELGKARES-GVILEGALARAEEKVRVAEANAEAKIKEAVQGESAAVS 184
T EA +L K S G L+ +E+ R + N K+++ ++
Sbjct: 1292 VTGMLSEAEGKAIKLAKEVASLGSQLQDTQELLQEETR-QKLNVSTKLRQLEDERNSLQE 1350
Query: 185 EKQELLAYVDKLKAQLQRQHIDSTEVFEKTESCSDT-KHVDLTEENVDKACLSVSRSVPD 243
+ E + L+ + +I ++ +K + + T + ++ ++ K S+++ +
Sbjct: 1351 QLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVESLEEGKKRFQKEIESLTQQYEE 1410
Query: 244 PAAA 247
AAA
Sbjct: 1411 KAAA 1414
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.307 0.122 0.315
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,900,503
Number of Sequences: 164201
Number of extensions: 1120160
Number of successful extensions: 8787
Number of sequences better than 10.0: 998
Number of HSP's better than 10.0 without gapping: 244
Number of HSP's successfully gapped in prelim test: 765
Number of HSP's that attempted gapping in prelim test: 6303
Number of HSP's gapped (non-prelim): 2454
length of query: 306
length of database: 59,974,054
effective HSP length: 110
effective length of query: 196
effective length of database: 41,911,944
effective search space: 8214741024
effective search space used: 8214741024
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 65 (29.6 bits)
Lotus: description of TM0057b.10