BLASTP 2.2.2 [Dec-14-2001]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= TM0046a.5
         (327 letters)

Database: sprot 
           164,201 sequences; 59,974,054 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

ITN1_RAT (Q9WVE9) Intersectin 1 (EH domain and SH3 domain regula...    62  3e-09
ITN1_MOUSE (Q9Z0R4) Intersectin 1 (EH and SH3 domains protein 1)       61  3e-09
ARH6_HUMAN (Q15052) Rho guanine nucleotide exchange factor 6 (PA...    59  2e-08
SH33_MOUSE (Q62421) SH3-containing GRB2-like protein 3 (SH3 doma...    56  1e-07
ITN2_MOUSE (Q9Z0R6) Intersectin 2 (SH3 domain-containing protein...    56  1e-07
ARH7_HUMAN (Q14155) Rho guanine nucleotide exchange factor 7 (PA...    56  1e-07
ITN1_HUMAN (Q15811) Intersectin 1 (SH3 domain-containing protein...    56  1e-07
ARH7_RAT (O55043) Rho guanine nucleotide exchange factor 7 (PAK-...    55  2e-07
ARH7_MOUSE (Q9ES28) Rho guanine nucleotide exchange factor 7 (PA...    55  2e-07
NUMA_HUMAN (Q14980) Nuclear mitotic apparatus protein 1 (NuMA pr...    53  9e-07
MYSB_ACACA (P19706) Myosin heavy chain IB (Myosin heavy chain IL)      53  9e-07
VAV_MOUSE (P27870) Vav proto-oncogene (p95vav)                         53  1e-06
VAV3_MOUSE (Q9R0C8) Vav-3 protein                                      53  1e-06
SH32_HUMAN (Q99962) SH3-containing GRB2-like protein 2 (EC 2.3.1...    52  2e-06
VAV3_HUMAN (Q9UKW4) Vav-3 protein                                      52  2e-06
SH32_MOUSE (Q62420) SH3-containing GRB2-like protein 2 (EC 2.3.1...    52  2e-06
ITN1_XENLA (O42287) Intersectin 1                                      52  2e-06
SRC8_HUMAN (Q14247) Src substrate cortactin (Amplaxin) (Oncogene...    52  3e-06
SH33_HUMAN (Q99963) SH3-containing GRB2-like protein 3 (SH3 doma...    52  3e-06
VAV_HUMAN (P15498) Vav proto-oncogene                                  51  3e-06

>ITN1_RAT (Q9WVE9) Intersectin 1 (EH domain and SH3 domain regulator
           of endocytosis 1)
          Length = 1217

 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 60/226 (26%), Positives = 99/226 (43%), Gaps = 34/226 (15%)

Query: 112 LGDARKHVEKEHEELNRLLASQVLDPLRQMINGVPLEDARHL-AQRYSRMRQEAETL--- 167
           L +  K    + +E++  + +  L  LR++ +   L+  R + A+R  +  QE ++L   
Sbjct: 585 LDEVEKETRSKLQEID--VFNNQLKELREIHSKQQLQKQRSIEAERLKQKEQERKSLELE 642

Query: 168 -REEISKRQVRVRESPTSEQVAKLHAAEARMK----ELKANMAVLGKEAAA-ALASVDAQ 221
            ++E  +R+V+ R+    E V +      R      +LK   +V  KEA   A   V  +
Sbjct: 643 KQKEEGQRRVQERDKQWQEHVQQEEQQRPRKPHEEDKLKREDSVKKKEAEERAKPEVQDK 702

Query: 222 QQRLTFQRLVAMMVSDRQKKESAP-------PVVVSENGSGKTMYFLAEATHPFYGDSEK 274
           Q RL           +  K   AP       P+ +S   S K +Y+   A +PF   S  
Sbjct: 703 QSRLFHPH------QEPAKPAQAPWPTTEKGPLTISAQESAKVVYY--RALYPFESRSHD 754

Query: 275 ELSFSKGDFIVVR-------KVTPTGWSEGECNGKAGWFPSAYVEK 313
           E++   GD ++V+       +    GW  GE  GK GWFP+ Y EK
Sbjct: 755 EITIQPGDIVMVKGEWVDESQTGEPGWLGGEPKGKTGWFPANYAEK 800



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 33/143 (23%), Positives = 59/143 (41%), Gaps = 26/143 (18%)

Query: 196  RMKELKANMAVLGKEAAAALASVDAQQQRLTFQRLVAMMVSDR----------------- 238
            R+    A  A+ G+E  A      ++   LTFQ+   ++V+ +                 
Sbjct: 989  RVASPAAKPAIPGEEFVAMYTYESSEHGDLTFQQGHVIVVTKKDGDWWTGTVGETSGVFP 1048

Query: 239  ----QKKESAPPVVVSENGSGKTMYFLAEATHPFYGDSEKELSFSKGDFIVVRKVTPTGW 294
                + K+S       + GS +    +A+    +     ++L+ + G  I++RK  P GW
Sbjct: 1049 SNYVRLKDSEGSGTAGKTGSLEKKPEIAQVIASYTATGPEQLTLAPGQLILIRKKNPGGW 1108

Query: 295  SEGECNGKA-----GWFPSAYVE 312
             EGE   +      GWFP+ YV+
Sbjct: 1109 WEGELQARGKKRQIGWFPANYVK 1131



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 19/51 (37%), Positives = 29/51 (56%), Gaps = 1/51 (1%)

Query: 262 AEATHPFYGDSEKELSFSKGDFIVVRKVTPTGWSEGECNGKAGWFPSAYVE 312
           A+A +P+    +  L+F+K D I V +     W  GE  G+ GWFP +YV+
Sbjct: 915 AQALYPWRAKKDNHLNFNKSDVITVLEQQDMWWF-GEVQGQKGWFPKSYVK 964



 Score = 39.3 bits (90), Expect = 0.014
 Identities = 18/47 (38%), Positives = 27/47 (57%)

Query: 266  HPFYGDSEKELSFSKGDFIVVRKVTPTGWSEGECNGKAGWFPSAYVE 312
            + +   ++ EL+FSKG  I V       W +GE +G+ G FPS YV+
Sbjct: 1161 YDYTAQNDDELAFSKGQIINVLSKEDPDWWKGEVSGQVGLFPSNYVK 1207


>ITN1_MOUSE (Q9Z0R4) Intersectin 1 (EH and SH3 domains protein 1)
          Length = 1714

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 60/222 (27%), Positives = 98/222 (44%), Gaps = 25/222 (11%)

Query: 115 ARKHVEKEHEELNRLLASQV---------LDPLRQMINGVPLEDARHL-AQRYSRMRQEA 164
           AR+ + ++ +E+ R   S++         L  LR++ +   L+  R L A R  +  QE 
Sbjct: 577 ARQQLREQLDEVERETRSKLQEIDVFNNQLKELREIHSKQQLQKQRSLEAARLKQKEQER 636

Query: 165 ETL----REEISKRQVRVRESPTSEQVAKLHAAEARMKE----LKANMAVLGKEAAA-AL 215
           ++L    ++E ++R+V+ R+    E V +      R       LK   +V  KEA   A 
Sbjct: 637 KSLELEKQKEDAQRRVQERDKQWLEHVQQEEQPRPRKPHEEDRLKREDSVRKKEAEERAK 696

Query: 216 ASVDAQQQRL--TFQRLVAMMVSDRQKKESAPPVVVSENGSGKTMYFLAEATHPFYGDSE 273
             +  +Q RL    Q    +            P+ +S   S K +Y+   A +PF   S 
Sbjct: 697 PEMQDKQSRLFHPHQEPAKLATQAPWSTTEKGPLTISAQESVKVVYY--RALYPFESRSH 754

Query: 274 KELSFSKGDFIVV--RKVTPTGWSEGECNGKAGWFPSAYVEK 313
            E++   GD ++V   +    GW  GE  GK GWFP+ Y EK
Sbjct: 755 DEITIQPGDIVMVDESQTGEPGWLGGELKGKTGWFPANYAEK 796



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 35/147 (23%), Positives = 61/147 (40%), Gaps = 26/147 (17%)

Query: 192  AAEARMKELKANMAVLGKEAAAALASVDAQQQRLTFQRLVAMMVSDR------------- 238
            A+  R+    A  A+ G+E  A      ++Q  LTFQ+   ++V+ +             
Sbjct: 981  ASLKRVASPAAKPAIPGEEFIAMYTYESSEQGDLTFQQGDVIVVTKKDGDWWTGTVGDKS 1040

Query: 239  --------QKKESAPPVVVSENGSGKTMYFLAEATHPFYGDSEKELSFSKGDFIVVRKVT 290
                    + K+S       + GS      +A+    +     ++L+ + G  I++RK  
Sbjct: 1041 GVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYAATGPEQLTLAPGQLILIRKKN 1100

Query: 291  PTGWSEGECNGKA-----GWFPSAYVE 312
            P GW EGE   +      GWFP+ YV+
Sbjct: 1101 PGGWWEGELQARGKKRQIGWFPANYVK 1127



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 19/51 (37%), Positives = 29/51 (56%), Gaps = 1/51 (1%)

Query: 262 AEATHPFYGDSEKELSFSKGDFIVVRKVTPTGWSEGECNGKAGWFPSAYVE 312
           A+A +P+    +  L+F+K D I V +     W  GE  G+ GWFP +YV+
Sbjct: 911 AQALYPWRAKKDNHLNFNKSDVITVLEQQDMWWF-GEVQGQKGWFPKSYVK 960



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 21/63 (33%), Positives = 35/63 (55%), Gaps = 1/63 (1%)

Query: 266  HPFYGDSEKELSFSKGDFIVVRKVTPTGWSEGECNGKAGWFPSAYVEKRQRV-PSSNFSS 324
            + +   ++ EL+FSKG  I V       W +GE +G+ G FPS YV+    + PS  + S
Sbjct: 1157 YDYTAQNDDELAFSKGQIINVLNKEDPDWWKGEVSGQVGLFPSNYVKLTTDMDPSQQWCS 1216

Query: 325  EVY 327
            +++
Sbjct: 1217 DLH 1219


>ARH6_HUMAN (Q15052) Rho guanine nucleotide exchange factor 6
           (PAK-interacting exchange factor alpha) (Alpha-Pix)
           (COOL-2)
          Length = 776

 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 35/86 (40%), Positives = 47/86 (53%), Gaps = 5/86 (5%)

Query: 228 QRLVAMMVSDRQKKESAPPVVVSENGSGKTMYFLAEATHPFYGDSEKELSFSKGDFIVVR 287
           Q  V+  VS  Q++     V ++ENGS +    + +A   F   +E ELS  KGD I V 
Sbjct: 136 QGAVSSTVSGLQRQSKT--VEMTENGSHQ---LIVKARFNFKQTNEDELSVCKGDIIYVT 190

Query: 288 KVTPTGWSEGECNGKAGWFPSAYVEK 313
           +V   GW EG  NG+ GWFPS YV +
Sbjct: 191 RVEEGGWWEGTLNGRTGWFPSNYVRE 216


>SH33_MOUSE (Q62421) SH3-containing GRB2-like protein 3 (SH3 domain
           protein 2C) (SH3p13)
          Length = 347

 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 62/262 (23%), Positives = 108/262 (40%), Gaps = 29/262 (11%)

Query: 76  AIGYKHIETGTKLSEDCC-KYGAENNIDNILAKAASVLGDARKHVEKEHEELNRLLASQV 134
           A GY   E    L  DC  KYG E   D+    +   +G+A K + +  + L+  +    
Sbjct: 83  ATGYPQTEG---LLGDCMLKYGKELGEDSAFGNSLVDVGEALKLMAEVKDSLDINVKQTF 139

Query: 135 LDPLRQMINGVPLEDARHLAQRYSRMRQEAETLREEISK-RQVRVRESPTSEQVAKLHAA 193
           +DPL Q++    L++  H  ++    R + +  +  + K  +  +R++    + +K  A 
Sbjct: 140 IDPL-QLLQDKDLKEIGHHLRKLEGRRLDYDYKKRRVGKIPEEEIRQAVEKFEESKELAE 198

Query: 194 EARMKELKANMAVLGKEAAAALASVDAQQQRLTFQR-------LVAMMVSDRQKKESAPP 246
            +    L+ ++  + + A    A++D  +Q     +       L   + S   K+E  P 
Sbjct: 199 RSMFNFLENDVEQVSQLAVFVEAALDYHRQSTEILQELQSKLELRISLASKVPKREFMPK 258

Query: 247 VV---------VSENGSGKTMYFLAEATHP-------FYGDSEKELSFSKGDFIVVRKVT 290
            V         V  + S KT      A  P       F  ++E EL F +GD I +    
Sbjct: 259 PVNMSSTDANGVGPSSSSKTPGTDTPADQPCCRGLYDFEPENEGELGFKEGDIITLTNQI 318

Query: 291 PTGWSEGECNGKAGWFPSAYVE 312
              W EG   G++G+FP  YVE
Sbjct: 319 DENWYEGMLRGESGFFPINYVE 340


>ITN2_MOUSE (Q9Z0R6) Intersectin 2 (SH3 domain-containing protein
           1B) (EH and SH3 domains protein 2) (EH domain and SH3
           domain regulator of endocytosis 2)
          Length = 1658

 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 46/165 (27%), Positives = 73/165 (43%), Gaps = 12/165 (7%)

Query: 151 RHLAQRYSRMRQEAETLREEISKRQVRVRESPTSEQVAKLHAAEARMKELKANMAVLGKE 210
           + L + Y+  +   E L + I + +++  E    EQ+ K    +   ++ K     L +E
Sbjct: 621 KELRESYNTQQLALEQLHK-IKRDKLKEIERKRLEQIQKKKLEDEAARKAKQGKENLWRE 679

Query: 211 AAAALASVDAQQQRLTFQRLVAMMVSDRQKKESAPPVVVSENGSGKTMYFLAEATHPFYG 270
           +       + +Q+RL  ++       + +K E+      SE  S    Y    A +PF  
Sbjct: 680 SIRK--EEEEKQKRLQEEKSQDKTQEEERKAEAKQ----SETASALVNY---RALYPFEA 730

Query: 271 DSEKELSFSKGDFIVV--RKVTPTGWSEGECNGKAGWFPSAYVEK 313
            +  E+SFS GD I V  + V   GW  G   GK GWFP  YVEK
Sbjct: 731 RNHDEMSFSSGDIIQVDEKTVGEPGWLYGSFQGKFGWFPCNYVEK 775



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 21/49 (42%), Positives = 28/49 (56%)

Query: 264  ATHPFYGDSEKELSFSKGDFIVVRKVTPTGWSEGECNGKAGWFPSAYVE 312
            A + +  ++E EL+FSKG  I V       W +GE NG  G FPS YV+
Sbjct: 1094 AMYDYMANNEDELNFSKGQLINVMNKDDPDWWQGETNGLTGLFPSNYVK 1142



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 18/68 (26%), Positives = 36/68 (52%), Gaps = 5/68 (7%)

Query: 250  SENGSGKTMYFLAEATHPFYGDSEKELSFSKGDFIVVRKVTPTGWSEGECNGKA-----G 304
            S++G+      +A+ T  +     ++LS + G  I++ K   +GW +GE   +      G
Sbjct: 1006 SKSGASNKKPEIAQVTSAYAASGTEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKG 1065

Query: 305  WFPSAYVE 312
            WFP+++V+
Sbjct: 1066 WFPASHVK 1073



 Score = 39.3 bits (90), Expect = 0.014
 Identities = 25/70 (35%), Positives = 36/70 (50%), Gaps = 2/70 (2%)

Query: 244 APPVVVSENGSGKTMYFL-AEATHPFYGDSEKELSFSKGDFIVVRKVTPTGWSEGECNGK 302
           +P  V   +G G+ +  L A+A   +    E  L+FSK D I V +     W  GE +G 
Sbjct: 837 SPGSVSPIHGQGQAVENLKAQALCSWTAKKENHLNFSKHDVITVLEQQENWWF-GEVHGG 895

Query: 303 AGWFPSAYVE 312
            GWFP +YV+
Sbjct: 896 RGWFPKSYVK 905


>ARH7_HUMAN (Q14155) Rho guanine nucleotide exchange factor 7
           (PAK-interacting exchange factor beta) (Beta-Pix)
           (COOL-1) (p85)
          Length = 803

 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 27/53 (50%), Positives = 32/53 (59%)

Query: 261 LAEATHPFYGDSEKELSFSKGDFIVVRKVTPTGWSEGECNGKAGWFPSAYVEK 313
           +  A   F   +E ELSFSKGD I V +V   GW EG  NG+ GWFPS YV +
Sbjct: 188 VVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVRE 240


>ITN1_HUMAN (Q15811) Intersectin 1 (SH3 domain-containing protein
           1A) (SH3P17)
          Length = 1721

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 55/232 (23%), Positives = 97/232 (41%), Gaps = 39/232 (16%)

Query: 115 ARKHVEKEHEELNRLLASQV---------LDPLRQMINGVPLEDARHL-AQRYSRMRQEA 164
           AR+H+  + +E+ +   S++         L  LR++ N   L+  + + A+R  +  QE 
Sbjct: 578 ARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQER 637

Query: 165 ETLREEISKRQVR-------------VRESPTSEQVAKLHAAEARMKE---LKANMAVLG 208
           + +  E  K + +             V++    ++  KLH  E   +E    K +    G
Sbjct: 638 KIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKG 697

Query: 209 KEAAAALASVDAQQQRLTFQRLVAMMVSDRQKKESAPPVVVSENGSGKTMYFLAEATHPF 268
           K+ A         Q +   +  V    S  +K     P+ +S   + K +Y+   A +PF
Sbjct: 698 KQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEKG----PLTISAQENVKVVYY--RALYPF 751

Query: 269 YGDSEKELSFSKGDFIVVR-------KVTPTGWSEGECNGKAGWFPSAYVEK 313
              S  E++   GD ++V+       +    GW  GE  GK GWFP+ Y EK
Sbjct: 752 ESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEK 803



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 39/159 (24%), Positives = 65/159 (40%), Gaps = 30/159 (18%)

Query: 180  ESPTSEQVAKLHAAEARMKELKANMAVLGKEAAAALASVDAQQQRLTFQRLVAMMVSDR- 238
            +S +SE  A L     R+    A   V G+E  A      ++Q  LTFQ+   ++V+ + 
Sbjct: 980  DSGSSESPASLK----RVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKKD 1035

Query: 239  --------------------QKKESAPPVVVSENGSGKTMYFLAEATHPFYGDSEKELSF 278
                                + K+S       + GS      +A+    +     ++L+ 
Sbjct: 1036 GDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTL 1095

Query: 279  SKGDFIVVRKVTPTGWSEGECNGKA-----GWFPSAYVE 312
            + G  I++RK  P GW EGE   +      GWFP+ YV+
Sbjct: 1096 APGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVK 1134



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 19/51 (37%), Positives = 29/51 (56%), Gaps = 1/51 (1%)

Query: 262 AEATHPFYGDSEKELSFSKGDFIVVRKVTPTGWSEGECNGKAGWFPSAYVE 312
           A+A +P+    +  L+F+K D I V +     W  GE  G+ GWFP +YV+
Sbjct: 918 AQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQGQKGWFPKSYVK 967



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 21/63 (33%), Positives = 35/63 (55%), Gaps = 1/63 (1%)

Query: 266  HPFYGDSEKELSFSKGDFIVVRKVTPTGWSEGECNGKAGWFPSAYVEKRQRV-PSSNFSS 324
            + +   ++ EL+F+KG  I V       W +GE NG+ G FPS YV+    + PS  + S
Sbjct: 1164 YDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPSQQWCS 1223

Query: 325  EVY 327
            +++
Sbjct: 1224 DLH 1226


>ARH7_RAT (O55043) Rho guanine nucleotide exchange factor 7
           (PAK-interacting exchange factor beta) (Beta-Pix)
          Length = 646

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 27/53 (50%), Positives = 32/53 (59%)

Query: 261 LAEATHPFYGDSEKELSFSKGDFIVVRKVTPTGWSEGECNGKAGWFPSAYVEK 313
           +  A   F   +E ELSFSKGD I V +V   GW EG  NG+ GWFPS YV +
Sbjct: 10  VVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTHNGRTGWFPSNYVRE 62


>ARH7_MOUSE (Q9ES28) Rho guanine nucleotide exchange factor 7
           (PAK-interacting exchange factor beta) (Beta-Pix)
           (p85SPR)
          Length = 705

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 27/53 (50%), Positives = 32/53 (59%)

Query: 261 LAEATHPFYGDSEKELSFSKGDFIVVRKVTPTGWSEGECNGKAGWFPSAYVEK 313
           +  A   F   +E ELSFSKGD I V +V   GW EG  NG+ GWFPS YV +
Sbjct: 10  VVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTHNGRTGWFPSNYVRE 62


>NUMA_HUMAN (Q14980) Nuclear mitotic apparatus protein 1 (NuMA
            protein) (SP-H antigen)
          Length = 2115

 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 50/213 (23%), Positives = 97/213 (45%), Gaps = 14/213 (6%)

Query: 1    MDALRKQASKLREQVSKQQQAV------IKQFSTSGYESSDVVVIDEGEMQIHQQLEKLY 54
            ++ALR + SKL +Q  KQQ+        ++    S  E    +   +G  Q+ ++ ++L 
Sbjct: 1122 LEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQG--QLEEKAQELG 1179

Query: 55   KATRTMRDFQKEIVKAAETFTAIGYKHIETGTKLSEDCCKYGAENNIDNILAKAASVLGD 114
             +   +   Q+E+               E   +++    +   +N++ + L +  S+L  
Sbjct: 1180 HSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNR 1239

Query: 115  ARKHVEKEHEELNRLLA-----SQVLDPLRQMINGVPLEDARHLAQRYSRMRQEAETLRE 169
                 E E +EL RL+      SQ L+   +++      ++   A+R S +R+E ++LRE
Sbjct: 1240 QVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLRE 1299

Query: 170  EISKRQVRVRESPTSEQVAKLHAAEARMKELKA 202
            E  K++V   E+   E  ++   AE   +ELKA
Sbjct: 1300 EAEKQRV-ASENLRQELTSQAERAEELGQELKA 1331


>MYSB_ACACA (P19706) Myosin heavy chain IB (Myosin heavy chain IL)
          Length = 1147

 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 22/50 (44%), Positives = 32/50 (64%)

Query: 263  EATHPFYGDSEKELSFSKGDFIVVRKVTPTGWSEGECNGKAGWFPSAYVE 312
            +A + +   +  EL+F +GD I+V +  P GW EGE NGK GW P+ YV+
Sbjct: 1096 KALYDYDAQTGDELTFKEGDTIIVHQKDPAGWWEGELNGKRGWVPANYVQ 1145


>VAV_MOUSE (P27870) Vav proto-oncogene (p95vav)
          Length = 845

 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 28/67 (41%), Positives = 38/67 (55%), Gaps = 2/67 (2%)

Query: 249 VSENGSGKTMYF-LAEATHPFYGDSEKELSFSKGDFI-VVRKVTPTGWSEGECNGKAGWF 306
           +S+  +G T YF  A+A + F      ELS  +GD I ++ K    GW  GE  G+ GWF
Sbjct: 773 ISKPPAGSTKYFGTAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRIGWF 832

Query: 307 PSAYVEK 313
           PS YVE+
Sbjct: 833 PSNYVEE 839


>VAV3_MOUSE (Q9R0C8) Vav-3 protein
          Length = 847

 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 29/79 (36%), Positives = 41/79 (51%), Gaps = 6/79 (7%)

Query: 241 KESAPPVVVSENGSGKTMYF-----LAEATHPFYGDSEKELSFSKGDFI-VVRKVTPTGW 294
           KE   P     N +G ++       +A A + F     +ELS  KGD + +  K++  GW
Sbjct: 767 KEPEQPAGQRGNRTGNSLLSPKVLGIAIARYDFCARDMRELSLLKGDMVKIYTKMSANGW 826

Query: 295 SEGECNGKAGWFPSAYVEK 313
             GE NG+ GWFPS YVE+
Sbjct: 827 WRGEVNGRVGWFPSTYVEE 845


>SH32_HUMAN (Q99962) SH3-containing GRB2-like protein 2 (EC 2.3.1.-)
           (SH3 domain protein 2A) (Endophilin 1) (EEN-B1)
          Length = 352

 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 62/263 (23%), Positives = 108/263 (40%), Gaps = 30/263 (11%)

Query: 78  GYKHIETGTKLSEDCCKYGAENNIDNILAKAASVLGDARKHVEKEHEELNRLLASQVLDP 137
           GY   E    L+E   K+G E   D     A   +G+A + + +  + L+  +    +DP
Sbjct: 85  GYPQAEA--LLAEAMLKFGRELGDDCNFGPALGEVGEAMRELSEVKDSLDIEVKQNFIDP 142

Query: 138 L--------RQMINGVPLEDARHLAQRYSRMRQEA---ETLREEISKRQVRVRESPTS-- 184
           L        R++ + +   + R L   Y + RQ     E LR+ + K       + +S  
Sbjct: 143 LQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPDEELRQALEKFDESKEIAESSMF 202

Query: 185 -------EQVAKLHA-AEARMKELKANMAVLGKEAAAALASVD--AQQQRLTFQRLVAMM 234
                  EQV++L A  +A+++  K  + +L +        +   + Q R  +Q    M 
Sbjct: 203 NLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRLEERIRQASSQPRREYQPKPRMS 262

Query: 235 VSDRQKKESAPPVVVSENGSGKTMYFLAE-----ATHPFYGDSEKELSFSKGDFIVVRKV 289
           +       + P   +S  G+ K      +     A + F  ++E EL F +GD I +   
Sbjct: 263 LEFPTGDSTQPNGGLSHTGTPKPSGVQMDQPCCRALYDFEPENEGELGFKEGDIITLTNQ 322

Query: 290 TPTGWSEGECNGKAGWFPSAYVE 312
               W EG  +G +G+FP  YVE
Sbjct: 323 IDENWYEGMLHGHSGFFPINYVE 345


>VAV3_HUMAN (Q9UKW4) Vav-3 protein
          Length = 847

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 24/54 (44%), Positives = 33/54 (60%), Gaps = 1/54 (1%)

Query: 261 LAEATHPFYGDSEKELSFSKGDFI-VVRKVTPTGWSEGECNGKAGWFPSAYVEK 313
           +A A + F     +ELS  KGD + +  K++  GW  GE NG+ GWFPS YVE+
Sbjct: 792 IAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYVEE 845


>SH32_MOUSE (Q62420) SH3-containing GRB2-like protein 2 (EC 2.3.1.-)
           (SH3 domain protein 2A) (Endophilin 1) (SH3p4)
          Length = 352

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 61/263 (23%), Positives = 109/263 (41%), Gaps = 30/263 (11%)

Query: 78  GYKHIETGTKLSEDCCKYGAENNIDNILAKAASVLGDARKHVEKEHEELNRLLASQVLDP 137
           GY   E    L+E   K+G E   D     A   +G+A + + +  + L+  +    +DP
Sbjct: 85  GYPQAEA--LLAEAMLKFGRELGDDCNFGPALGEVGEAMRELSEVKDSLDMEVKQNFIDP 142

Query: 138 L--------RQMINGVPLEDARHLAQRYSRMRQEA---ETLREEISKRQVRVRESPTS-- 184
           L        R++ + +   + R L   Y + RQ     E LR+ + K       + +S  
Sbjct: 143 LQNLHDKDLREIQHHLKKLEGRRLDFGYKKKRQGKIPDEELRQALEKFDESKEIAESSMF 202

Query: 185 -------EQVAKLHA-AEARMKELKANMAVLGKEAAAALASVD--AQQQRLTFQRLVAMM 234
                  EQV++L A  +A+++  K  + +L +        +   + Q R  +Q    M 
Sbjct: 203 NLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRLEERIRQASSQPRREYQPKPRMS 262

Query: 235 VSDRQKKESAPPVVVSENGSGKTMYFLAE-----ATHPFYGDSEKELSFSKGDFIVVRKV 289
           +       + P   +S  G+ K      +     A +    ++E EL+F +GD I +   
Sbjct: 263 LEFATGDSTQPNGGLSHTGTPKPPGVQMDQPCCRALYDLEPENEGELAFKEGDIITLTNQ 322

Query: 290 TPTGWSEGECNGKAGWFPSAYVE 312
               W EG  +G++G+FP  YVE
Sbjct: 323 IDENWYEGMLHGQSGFFPINYVE 345


>ITN1_XENLA (O42287) Intersectin 1
          Length = 1270

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 32/85 (37%), Positives = 42/85 (48%), Gaps = 9/85 (10%)

Query: 242 ESAPPVVVSENGSGKTMYFLAEATHPFYGDSEKELSFSKGDFIVV--RKVTPTGWSEGEC 299
           E AP  +    G  K +Y+   A +PF   S  E++   GD I+V   +    GW  GE 
Sbjct: 721 EKAPLTI--NQGDVKVVYY--RALYPFDARSHDEITIEPGDIIMVDESQTGEPGWLGGEL 776

Query: 300 NGKAGWFPSAYVEKRQRVPSSNFSS 324
            GK GWFP+ Y E   R+P S F S
Sbjct: 777 KGKTGWFPANYAE---RMPESEFPS 798



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 26/81 (32%), Positives = 40/81 (49%), Gaps = 7/81 (8%)

Query: 238 RQKKESAPPVVVSEN-----GSGKTMYFL-AEATHPFYGDSEKELSFSKGDFIVVRKVTP 291
           RQ+    P  V   +     G G+ +  L A+A +P+    +  L+F+K D I V +   
Sbjct: 872 RQRSAFTPATVTGSSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQD 931

Query: 292 TGWSEGECNGKAGWFPSAYVE 312
             W  GE  G+ GWFP +YV+
Sbjct: 932 MWWF-GEVQGQKGWFPKSYVK 951



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 18/57 (31%), Positives = 31/57 (53%), Gaps = 5/57 (8%)

Query: 261  LAEATHPFYGDSEKELSFSKGDFIVVRKVTPTGWSEGECNGKA-----GWFPSAYVE 312
            +A+    +   + ++L+ + G  I++RK  P GW EGE   +      GWFP+ YV+
Sbjct: 1062 IAQVIASYAATAPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVK 1118



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 19/47 (40%), Positives = 26/47 (54%)

Query: 266  HPFYGDSEKELSFSKGDFIVVRKVTPTGWSEGECNGKAGWFPSAYVE 312
            + +   ++ EL+FSKG  I V       W +GE NG  G FPS YV+
Sbjct: 1148 YDYIAQNDDELAFSKGQVINVLNKEDPDWWKGELNGHVGLFPSNYVK 1194



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 17/49 (34%), Positives = 26/49 (52%), Gaps = 1/49 (2%)

Query: 266  HPFYGDSEKELSFSKGDFIVVRKVTPTGWSEGECNGKAGWFPSAYVEKR 314
            + +  + + +L+F +GD IVV K     W+ G    K G FPS YV  +
Sbjct: 995  YTYESNEQGDLTFQQGDLIVVIKKDGDWWT-GTVGEKTGVFPSNYVRPK 1042


>SRC8_HUMAN (Q14247) Src substrate cortactin (Amplaxin) (Oncogene
           EMS1)
          Length = 550

 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 47/200 (23%), Positives = 77/200 (38%), Gaps = 13/200 (6%)

Query: 120 EKEHEELNRLLASQVLDPLRQMINGVPLEDARHLAQRYSRMRQEAETLREEISKRQVRVR 179
           EKE E+  +  A +     R        E+AR   +  +R + +   +       + R+ 
Sbjct: 360 EKEQEDRRKAEAERAQ---RMAKERQEQEEARRKLEEQARAKTQTPPVSPAPQPTEERLP 416

Query: 180 ESPTSEQVAKLHAAEARMKELKANMAVLGKEAAAALASVDAQQQRLTFQRLVAMMVSDRQ 239
            SP  E  A   A      EL     V G E     +   A  +  + Q+ +A       
Sbjct: 417 SSPVYEDAASFKA------ELSYRGPVSGTEPEPVYSMEAADYREASSQQGLAYATEAVY 470

Query: 240 KKESAPPVVVSENGS----GKTMYFLAEATHPFYGDSEKELSFSKGDFIVVRKVTPTGWS 295
           +   AP    +E+ +       + + A A + +    + E+SF   D I   ++   GW 
Sbjct: 471 ESAEAPGHYPAEDSTYDEYENDLGYTAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWW 530

Query: 296 EGECNGKAGWFPSAYVEKRQ 315
            G C G+ G FP+ YVE RQ
Sbjct: 531 RGVCKGRYGLFPANYVELRQ 550


>SH33_HUMAN (Q99963) SH3-containing GRB2-like protein 3 (SH3 domain
           protein 2C) (EEN-B2)
          Length = 347

 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 52/247 (21%), Positives = 104/247 (42%), Gaps = 26/247 (10%)

Query: 91  DCC-KYGAENNIDNILAKAASVLGDARKHVEKEHEELNRLLASQVLDPLRQMINGVPLED 149
           DC  KYG E   D+    A   +G++ K + +  + L+  +    +DPL Q++    L++
Sbjct: 95  DCMLKYGKELGEDSTFGNALIEVGESMKLMAEVKDSLDINVKQTFIDPL-QLLQDKDLKE 153

Query: 150 ARHLAQRYSRMRQEAETLREEISK-RQVRVRESPTSEQVAKLHAAEARMKELKANMAVLG 208
             H  ++    R + +  ++ + K     VR++    + +K  A  +    L+ ++  + 
Sbjct: 154 IGHHLKKLEGRRLDYDYKKKRVGKIPDEEVRQAVEKFEESKELAERSMFNFLENDVEQVS 213

Query: 209 KEAAAALASVDAQQQRLTF---------QRLVAMMVSDRQKKESAPPVVVSENGSGKTMY 259
           + A    A++D  +Q              R+ A     R++ +  P    S   +G +  
Sbjct: 214 QLAVFIEAALDYHRQSTEILQELQSKLQMRISAASSVPRREYKPRPVKRSSSELNGVSTT 273

Query: 260 FLAEAT--------------HPFYGDSEKELSFSKGDFIVVRKVTPTGWSEGECNGKAGW 305
            + + T              + F  +++ EL F +GD I +       W EG  +G++G+
Sbjct: 274 SVVKTTGSNIPMDQPCCRGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHGESGF 333

Query: 306 FPSAYVE 312
           FP  YVE
Sbjct: 334 FPINYVE 340


>VAV_HUMAN (P15498) Vav proto-oncogene
          Length = 845

 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 27/67 (40%), Positives = 36/67 (53%), Gaps = 2/67 (2%)

Query: 249 VSENGSGKTMYF-LAEATHPFYGDSEKELSFSKGDFI-VVRKVTPTGWSEGECNGKAGWF 306
           +S    G T YF  A+A + F      ELS  +GD I ++ K    GW  GE  G+ GWF
Sbjct: 773 ISRPAVGSTKYFGTAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWF 832

Query: 307 PSAYVEK 313
           P+ YVE+
Sbjct: 833 PANYVEE 839


  Database: sprot
    Posted date:  Nov 25, 2004 10:54 AM
  Number of letters in database: 59,974,054
  Number of sequences in database:  164,201
  
Lambda     K      H
   0.313    0.127    0.343 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,022,679
Number of Sequences: 164201
Number of extensions: 1346096
Number of successful extensions: 5448
Number of sequences better than 10.0: 389
Number of HSP's better than 10.0 without gapping: 130
Number of HSP's successfully gapped in prelim test: 262
Number of HSP's that attempted gapping in prelim test: 5027
Number of HSP's gapped (non-prelim): 618
length of query: 327
length of database: 59,974,054
effective HSP length: 110
effective length of query: 217
effective length of database: 41,911,944
effective search space: 9094891848
effective search space used: 9094891848
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)