BLASTP 2.2.2 [Dec-14-2001]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= TM0030.6
         (780 letters)

Database: sprot 
           164,201 sequences; 59,974,054 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

CLCG_ARATH (P60300) Putative chloride channel-like protein CLC-G     1148  0.0
CLCC_ARATH (Q96282) Chloride channel protein CLC-c (AtCLC-c)          946  0.0
CLCB_ARATH (P92942) Chloride channel protein CLC-b (AtCLC-b)          822  0.0
CLCA_ARATH (P92941) Chloride channel protein CLC-a (AtCLC-a)          815  0.0
CLCD_ARATH (P92943) Chloride channel protein CLC-d (AtCLC-d)          640  0.0
CLC7_HUMAN (P51798) Chloride channel protein 7 (ClC-7)                404  e-112
CLC7_RAT (P51799) Chloride channel protein 7 (ClC-7)                  402  e-111
CLC7_MOUSE (O70496) Chloride channel protein 7 (ClC-7)                402  e-111
CLC6_HUMAN (P51797) Chloride channel protein 6 (ClC-6)                328  3e-89
CLC6_MOUSE (O35454) Chloride channel protein 6 (ClC-6)                326  1e-88
CLC6_RABIT (Q9TT16) Chloride channel protein 6 (ClC-6)                320  1e-86
CLC3_HUMAN (P51790) Chloride channel protein 3 (ClC-3)                197  7e-50
CLC3_CAVPO (Q9R279) Chloride channel protein 3 (ClC-3)                197  7e-50
CLC3_MOUSE (P51791) Chloride channel protein 3 (ClC-3)                197  9e-50
CLC3_RAT (P51792) Chloride channel protein 3 (ClC-3)                  197  1e-49
CLC3_RABIT (O18894) Chloride channel protein 3 (ClC-3)                197  1e-49
CLC4_HUMAN (P51793) Chloride channel protein 4 (ClC-4)                192  3e-48
CLC5_RAT (P51796) Chloride channel protein 5 (ClC-5)                  191  5e-48
CLC5_MOUSE (Q9WVD4) Chloride channel protein 5 (ClC-5)                191  6e-48
CLC5_HUMAN (P51795) Chloride channel protein 5 (ClC-5)                187  7e-47

>CLCG_ARATH (P60300) Putative chloride channel-like protein CLC-G
          Length = 763

 Score = 1148 bits (2970), Expect = 0.0
 Identities = 562/763 (73%), Positives = 654/763 (85%), Gaps = 2/763 (0%)

Query: 6   LSNGDSEHRLRQPLLSSQRSIINSSSQVAIVGANVCPIESLDYEIFENEFFKQDWRSRGS 65
           + N  +E  +  PLL S R   NS+SQVAIVGANVCPIESLDYEI EN+FFKQDWR R  
Sbjct: 1   MPNSTTEDSVAVPLLPSLRRATNSTSQVAIVGANVCPIESLDYEIAENDFFKQDWRGRSK 60

Query: 66  LQIFQYVLMKWLLCFLIGTILGLIGFCNNLAVENLAGVKFVVTSNMMLHKRFSLAFVTFF 125
           ++IFQYV MKWLLCF IG I+ LIGF NNLAVENLAGVKFVVTSNMM+  RF++ FV F 
Sbjct: 61  VEIFQYVFMKWLLCFCIGIIVSLIGFANNLAVENLAGVKFVVTSNMMIAGRFAMGFVVFS 120

Query: 126 ASNLALTLFATIITAMIAPAAAGSGISEVKAYLNGVDAPGIFTLPTLIVKIIGSITAVSS 185
            +NL LTLFA++ITA +APAAAGSGI EVKAYLNGVDAP IF+L TLI+KIIG+I+AVS+
Sbjct: 121 VTNLILTLFASVITAFVAPAAAGSGIPEVKAYLNGVDAPEIFSLRTLIIKIIGNISAVSA 180

Query: 186 SLHIGKAGPMLHTGACVAALLGQGGSKRYGLTWKWLRYFKNDRDRRDLIVCGSAAGIAAA 245
           SL IGKAGPM+HTGACVA++LGQGGSKRY LTW+WLR+FKNDRDRRDL+ CG+AAGIAA+
Sbjct: 181 SLLIGKAGPMVHTGACVASILGQGGSKRYRLTWRWLRFFKNDRDRRDLVTCGAAAGIAAS 240

Query: 246 FRAPVGGVLFALEEMASWWRTALLWRAFFTTAIVAIFLRAMIDVCLSGKCGLFGKGGLIM 305
           FRAPVGGVLFALEEM+SW  +ALLWR FF+TA+VAI LRA+IDVCLSGKCGLFGKGGLIM
Sbjct: 241 FRAPVGGVLFALEEMSSW--SALLWRIFFSTAVVAIVLRALIDVCLSGKCGLFGKGGLIM 298

Query: 306 FDAYSGSLMYHAKDVPLVFILGVIGGILGSLYNYLWNKVLRIYNAINEKGTICKILLACV 365
           FD YS +  YH  DV  V +LGV+GGILGSLYN+L +KVLR YN I EKG   KILLAC 
Sbjct: 299 FDVYSENASYHLGDVLPVLLLGVVGGILGSLYNFLLDKVLRAYNYIYEKGVTWKILLACA 358

Query: 366 ISMFTSCLLFGLPWLASCQPCPADPVEPCPTIGRSGIYKKFQCPPGHYNDLASLIFNTND 425
           IS+FTSCLLFGLP+LASCQPCP D +E CPTIGRSG +KK+QCPPGHYNDLASLIFNTND
Sbjct: 359 ISIFTSCLLFGLPFLASCQPCPVDALEECPTIGRSGNFKKYQCPPGHYNDLASLIFNTND 418

Query: 426 DAIRNLFSKNTDSEFQYSSMFIFFITGFFLSILSCGVVVPAGVFVPIIVTGASYGRFVGM 485
           DAI+NLFSKNTD EF Y S+ +FF+T FFLSI S G+V PAG+FVP+IVTGASYGRFVGM
Sbjct: 419 DAIKNLFSKNTDFEFHYFSVLVFFVTCFFLSIFSYGIVAPAGLFVPVIVTGASYGRFVGM 478

Query: 486 LFGKKSNLNHGLYAVLGAASFLGGSMRTTVSLCVIILELTNNLLLLPLIMMVLLVSKSVA 545
           L G  SNLNHGL+AVLGAASFLGG+MR TVS CVI+LELTNNLLLLP++M+VLL+SK+VA
Sbjct: 479 LLGSNSNLNHGLFAVLGAASFLGGTMRMTVSTCVILLELTNNLLLLPMMMVVLLISKTVA 538

Query: 546 DVFNANIYDLIMKSKGLPYLETHAEPYMRQLTVGDVVTGPLQIFHGYEKVRNVVFVLKTT 605
           D FNANIY+LIMK KG PYL +HAEPYMRQL VGDVVTGPLQ+F+G EKV  +V VLKTT
Sbjct: 539 DGFNANIYNLIMKLKGFPYLYSHAEPYMRQLLVGDVVTGPLQVFNGIEKVETIVHVLKTT 598

Query: 606 SHNGFPVIDEPPFSEAPVLFGIILRHHLLTLLRKKVFMSAPMAMGGDVLRQFSADDFAKR 665
           +HNGFPV+D PP + APVL G+ILR H+LTLL+K+VFM +P+A   + L QF A++FAK+
Sbjct: 599 NHNGFPVVDGPPLAAAPVLHGLILRAHILTLLKKRVFMPSPVACDSNTLSQFKAEEFAKK 658

Query: 666 GSDRGERIEDIHLTQEEMDMFIDLHPFTNASPYTVVESMSLGKALILFRELGLRHLLVIP 725
           GS R ++IED+ L++EE++M++DLHPF+NASPYTVVE+MSL KALILFRE+G+RHLLVIP
Sbjct: 659 GSGRSDKIEDVELSEEELNMYLDLHPFSNASPYTVVETMSLAKALILFREVGIRHLLVIP 718

Query: 726 KIPSRSPVVGILTRHDFTAEHILGTHPYLVRSRWKRLRFWQPF 768
           K  +R PVVGILTRHDF  EHILG HP + RS+WKRLR   PF
Sbjct: 719 KTSNRPPVVGILTRHDFMPEHILGLHPSVSRSKWKRLRIRLPF 761


>CLCC_ARATH (Q96282) Chloride channel protein CLC-c (AtCLC-c)
          Length = 779

 Score =  946 bits (2446), Expect = 0.0
 Identities = 460/746 (61%), Positives = 563/746 (74%), Gaps = 3/746 (0%)

Query: 10  DSEHRLRQPLLSSQRSIINSSSQVAIVGANVCPIESLDYEIFENEFFKQDWRSRGSLQIF 69
           D     RQPLL+  R   N++SQ+AIVGAN CPIESLDYEIFEN+FFKQDWRSR  ++I 
Sbjct: 32  DGSVGFRQPLLARNRK--NTTSQIAIVGANTCPIESLDYEIFENDFFKQDWRSRKKIEIL 89

Query: 70  QYVLMKWLLCFLIGTILGLIGFCNNLAVENLAGVKFVVTSNMMLHKRFSLAFVTFFASNL 129
           QY  +KW L FLIG   GL+GF NNL VEN+AG K ++  N+ML +++  AF  F   NL
Sbjct: 90  QYTFLKWALAFLIGLATGLVGFLNNLGVENIAGFKLLLIGNLMLKEKYFQAFFAFAGCNL 149

Query: 130 ALTLFATIITAMIAPAAAGSGISEVKAYLNGVDAPGIFTLPTLIVKIIGSITAVSSSLHI 189
            L   A  + A IAPAAAGSGI EVKAYLNG+DA  I    TL VKI GSI  V++   +
Sbjct: 150 ILATAAASLCAFIAPAAAGSGIPEVKAYLNGIDAYSILAPSTLFVKIFGSIFGVAAGFVV 209

Query: 190 GKAGPMLHTGACVAALLGQGGSKRYGLTWKWLRYFKNDRDRRDLIVCGSAAGIAAAFRAP 249
           GK GPM+HTGAC+A LLGQGGSK+Y LTWKWLR+FKNDRDRRDLI CG+AAG+AAAFRAP
Sbjct: 210 GKEGPMVHTGACIANLLGQGGSKKYRLTWKWLRFFKNDRDRRDLITCGAAAGVAAAFRAP 269

Query: 250 VGGVLFALEEMASWWRTALLWRAFFTTAIVAIFLRAMIDVCLSGKCGLFGKGGLIMFDAY 309
           VGGVLFALEE ASWWR ALLWR FFTTA+VA+ LR++I+ C SG+CGLFGKGGLIMFD  
Sbjct: 270 VGGVLFALEEAASWWRNALLWRTFFTTAVVAVVLRSLIEFCRSGRCGLFGKGGLIMFDVN 329

Query: 310 SGSLMYHAKDVPLVFILGVIGGILGSLYNYLWNKVLRIYNAINEKGTICKILLACVISMF 369
           SG ++Y   D+  +  LGVIGG+LGSLYNYL +KVLR Y+ INEKG   KI+L   +S+ 
Sbjct: 330 SGPVLYSTPDLLAIVFLGVIGGVLGSLYNYLVDKVLRTYSIINEKGPRFKIMLVMAVSIL 389

Query: 370 TSCLLFGLPWLASCQPCPADPVE-PCPTIGRSGIYKKFQCPPGHYNDLASLIFNTNDDAI 428
           +SC  FGLPWL+ C PCP    E  CP++GRS IYK FQCPP HYNDL+SL+ NTNDDAI
Sbjct: 390 SSCCAFGLPWLSQCTPCPIGIEEGKCPSVGRSSIYKSFQCPPNHYNDLSSLLLNTNDDAI 449

Query: 429 RNLFSKNTDSEFQYSSMFIFFITGFFLSILSCGVVVPAGVFVPIIVTGASYGRFVGMLFG 488
           RNLF+  +++EF  S++ IFF+  + L I++ G+ +P+G+F+P+I+ GASYGR VG L G
Sbjct: 450 RNLFTSRSENEFHISTLAIFFVAVYCLGIITYGIAIPSGLFIPVILAGASYGRLVGRLLG 509

Query: 489 KKSNLNHGLYAVLGAASFLGGSMRTTVSLCVIILELTNNLLLLPLIMMVLLVSKSVADVF 548
             S L+ GL+++LGAASFLGG+MR TVSLCVI+LELTNNLL+LPL+M+VLL+SK+VAD F
Sbjct: 510 PVSQLDVGLFSLLGAASFLGGTMRMTVSLCVILLELTNNLLMLPLVMLVLLISKTVADCF 569

Query: 549 NANIYDLIMKSKGLPYLETHAEPYMRQLTVGDVVTGPLQIFHGYEKVRNVVFVLKTTSHN 608
           N  +YD I+  KGLPY+E HAEPYMR L   DVV+G L  F   EKV  +   LK T HN
Sbjct: 570 NRGVYDQIVTMKGLPYMEDHAEPYMRNLVAKDVVSGALISFSRVEKVGVIWQALKMTRHN 629

Query: 609 GFPVIDEPPFSEAPVLFGIILRHHLLTLLRKKVFMSAPMAMGGDVLRQFSADDFAKRGSD 668
           GFPVIDEPPF+EA  L GI LR HLL LL+ K F       G  +LR   A DF K G  
Sbjct: 630 GFPVIDEPPFTEASELCGIALRSHLLVLLQGKKFSKQRTTFGSQILRSCKARDFGKAGLG 689

Query: 669 RGERIEDIHLTQEEMDMFIDLHPFTNASPYTVVESMSLGKALILFRELGLRHLLVIPKIP 728
           +G +IED+ L++EEM+M++DLHP TN SPYTV+E++SL KA ILFR+LGLRHL V+PK P
Sbjct: 690 KGLKIEDLDLSEEEMEMYVDLHPITNTSPYTVLETLSLAKAAILFRQLGLRHLCVVPKTP 749

Query: 729 SRSPVVGILTRHDFTAEHILGTHPYL 754
            R P+VGILTRHDF  EH+LG +P++
Sbjct: 750 GRPPIVGILTRHDFMPEHVLGLYPHI 775


>CLCB_ARATH (P92942) Chloride channel protein CLC-b (AtCLC-b)
          Length = 780

 Score =  822 bits (2122), Expect = 0.0
 Identities = 409/762 (53%), Positives = 546/762 (70%), Gaps = 18/762 (2%)

Query: 9   GDSE-HRLRQPLLSSQRSIINSSSQVAIVGANVCPIESLDYEIFENEFFKQDWRSRGSLQ 67
           GD E + L QPL+ + R++  SS+ +A+VGA V  IESLDYEI EN+ FK DWR R   Q
Sbjct: 20  GDPESNTLNQPLVKANRTL--SSTPLALVGAKVSHIESLDYEINENDLFKHDWRKRSKAQ 77

Query: 68  IFQYVLMKWLLCFLIGTILGLIGFCNNLAVENLAGVKFVVTSNMMLHKRFSLAFVTFFAS 127
           + QYV +KW L  L+G   GLI    NLAVEN+AG K +   + +  +R+    +    +
Sbjct: 78  VLQYVFLKWTLACLVGLFTGLIATLINLAVENIAGYKLLAVGHFLTQERYVTGLMVLVGA 137

Query: 128 NLALTLFATIITAMIAPAAAGSGISEVKAYLNGVDAPGIFTLPTLIVKIIGSITAVSSSL 187
           NL LTL A+++    AP AAG GI E+KAYLNGVD P +F   T+IVKI+GSI AV++ L
Sbjct: 138 NLGLTLVASVLCVCFAPTAAGPGIPEIKAYLNGVDTPNMFGATTMIVKIVGSIGAVAAGL 197

Query: 188 HIGKAGPMLHTGACVAALLGQGGSKRYGLTWKWLRYFKNDRDRRDLIVCGSAAGIAAAFR 247
            +GK GP++H G+C+A+LLGQGG+  + + W+WLRYF NDRDRRDLI CGSAAG+ AAFR
Sbjct: 198 DLGKEGPLVHIGSCIASLLGQGGTDNHRIKWRWLRYFNNDRDRRDLITCGSAAGVCAAFR 257

Query: 248 APVGGVLFALEEMASWWRTALLWRAFFTTAIVAIFLRAMIDVCLSGKCGLFGKGGLIMFD 307
           +PVGGVLFALEE+A+WWR+ALLWR FF+TA+V + LR  I++C SGKCGLFGKGGLIMFD
Sbjct: 258 SPVGGVLFALEEVATWWRSALLWRTFFSTAVVVVVLREFIEICNSGKCGLFGKGGLIMFD 317

Query: 308 AYSGSLMYHAKDVPLVFILGVIGGILGSLYNYLWNKVLRIYNAINEKGTICKILLACVIS 367
               +  YH  D+  V ++GVIGGILGSLYN+L +KVLR+YN INEKG I K+LL+  +S
Sbjct: 318 VSHVTYTYHVTDIIPVMLIGVIGGILGSLYNHLLHKVLRLYNLINEKGKIHKVLLSLTVS 377

Query: 368 MFTSCLLFGLPWLASCQPCPADPVEPCPTIGRSGIYKKFQCPPGHYNDLASLIFNTNDDA 427
           +FTS  L+GLP+LA C+PC     E CPT GRSG +K+F CP G+YNDLA+L+  TNDDA
Sbjct: 378 LFTSVCLYGLPFLAKCKPCDPSIDEICPTNGRSGNFKQFHCPKGYYNDLATLLLTTNDDA 437

Query: 428 IRNLFSKNTDSEFQYSSMFIFFITGFFLSILSCGVVVPAGVFVPIIVTGASYGRFVGMLF 487
           +RNLFS NT +EF   S++IFF+    L + + G+  P+G+F+PII+ GA+YGR +G   
Sbjct: 438 VRNLFSSNTPNEFGMGSLWIFFVLYCILGLFTFGIATPSGLFLPIILMGAAYGRMLGAAM 497

Query: 488 GKKSNLNHGLYAVLGAASFLGGSMRTTVSLCVIILELTNNLLLLPLIMMVLLVSKSVADV 547
           G  ++++ GLYAVLGAA+ + GSMR TVSLCVI LELTNNLLLLP+ M+VLL++K+V D 
Sbjct: 498 GSYTSIDQGLYAVLGAAALMAGSMRMTVSLCVIFLELTNNLLLLPITMIVLLIAKTVGDS 557

Query: 548 FNANIYDLIMKSKGLPYLETHAEPYMRQLTVGDV--VTGPLQIFHGYEKVRNVVFVLKTT 605
           FN +IYD+I+  KGLP+LE + EP+MR LTVG++     P+    G EKV N+V VLK T
Sbjct: 558 FNPSIYDIILHLKGLPFLEANPEPWMRNLTVGELGDAKPPVVTLQGVEKVSNIVDVLKNT 617

Query: 606 SHNGFPVIDEPPFSE------APVLFGIILRHHLLTLLRKKVFMSAP-MAMGGDVLRQFS 658
           +HN FPV+DE    +      A  L G+ILR HL+ +L+K+ F++        +V  +F 
Sbjct: 618 THNAFPVLDEAEVPQVGLATGATELHGLILRAHLVKVLKKRWFLTEKRRTEEWEVREKFP 677

Query: 659 ADDFAKRGSDRGERIEDIHLTQEEMDMFIDLHPFTNASPYTVVESMSLGKALILFRELGL 718
            D+ A    +R +  +D+ +T  EM+M++DLHP TN +PYTV+E+MS+ KAL+LFR++GL
Sbjct: 678 WDELA----EREDNFDDVAITSAEMEMYVDLHPLTNTTPYTVMENMSVAKALVLFRQVGL 733

Query: 719 RHLLVIPKIPSRS--PVVGILTRHDFTAEHILGTHPYLVRSR 758
           RHLL++PKI +    PVVGILTR D  A +IL   P L +S+
Sbjct: 734 RHLLIVPKIQASGMCPVVGILTRQDLRAYNILQAFPLLEKSK 775


>CLCA_ARATH (P92941) Chloride channel protein CLC-a (AtCLC-a)
          Length = 775

 Score =  815 bits (2106), Expect = 0.0
 Identities = 407/772 (52%), Positives = 547/772 (70%), Gaps = 17/772 (2%)

Query: 3   TNHLSNGDSE------HRLRQPLLSSQRSIINSSSQVAIVGANVCPIESLDYEIFENEFF 56
           +N   NG+ E      + L QPLL   R++  SS+ +A+VGA V  IESLDYEI EN+ F
Sbjct: 10  SNSNYNGEEEGEDPENNTLNQPLLKRHRTL--SSTPLALVGAKVSHIESLDYEINENDLF 67

Query: 57  KQDWRSRGSLQIFQYVLMKWLLCFLIGTILGLIGFCNNLAVENLAGVKFVVTSNMMLHKR 116
           K DWRSR   Q+FQY+ +KW L  L+G   GLI    NLAVEN+AG K +     +   R
Sbjct: 68  KHDWRSRSKAQVFQYIFLKWTLACLVGLFTGLIATLINLAVENIAGYKLLAVGYYIAQDR 127

Query: 117 FSLAFVTFFASNLALTLFATIITAMIAPAAAGSGISEVKAYLNGVDAPGIFTLPTLIVKI 176
           F    + F  +NL LTL AT++    AP AAG GI E+KAYLNG+D P +F   T++VKI
Sbjct: 128 FWTGLMVFTGANLGLTLVATVLVVYFAPTAAGPGIPEIKAYLNGIDTPNMFGFTTMMVKI 187

Query: 177 IGSITAVSSSLHIGKAGPMLHTGACVAALLGQGGSKRYGLTWKWLRYFKNDRDRRDLIVC 236
           +GSI AV++ L +GK GP++H G+C+A+LLGQGG   + + W+WLRYF NDRDRRDLI C
Sbjct: 188 VGSIGAVAAGLDLGKEGPLVHIGSCIASLLGQGGPDNHRIKWRWLRYFNNDRDRRDLITC 247

Query: 237 GSAAGIAAAFRAPVGGVLFALEEMASWWRTALLWRAFFTTAIVAIFLRAMIDVCLSGKCG 296
           GSA+G+ AAFR+PVGGVLFALEE+A+WWR+ALLWR FF+TA+V + LRA I++C SGKCG
Sbjct: 248 GSASGVCAAFRSPVGGVLFALEEVATWWRSALLWRTFFSTAVVVVVLRAFIEICNSGKCG 307

Query: 297 LFGKGGLIMFDAYSGSLMYHAKDVPLVFILGVIGGILGSLYNYLWNKVLRIYNAINEKGT 356
           LFG GGLIMFD     + YHA D+  V ++GV GGILGSLYN+L +KVLR+YN IN+KG 
Sbjct: 308 LFGSGGLIMFDVSHVEVRYHAADIIPVTLIGVFGGILGSLYNHLLHKVLRLYNLINQKGK 367

Query: 357 ICKILLACVISMFTSCLLFGLPWLASCQPCPADPVEPCPTIGRSGIYKKFQCPPGHYNDL 416
           I K+LL+  +S+FTS  LFGLP+LA C+PC     E CPT GRSG +K+F CP G+YNDL
Sbjct: 368 IHKVLLSLGVSLFTSVCLFGLPFLAECKPCDPSIDEICPTNGRSGNFKQFNCPNGYYNDL 427

Query: 417 ASLIFNTNDDAIRNLFSKNTDSEFQYSSMFIFFITGFFLSILSCGVVVPAGVFVPIIVTG 476
           ++L+  TNDDA+RN+FS NT +EF   S++IFF     L +++ G+  P+G+F+PII+ G
Sbjct: 428 STLLLTTNDDAVRNIFSSNTPNEFGMVSLWIFFGLYCILGLITFGIATPSGLFLPIILMG 487

Query: 477 ASYGRFVGMLFGKKSNLNHGLYAVLGAASFLGGSMRTTVSLCVIILELTNNLLLLPLIMM 536
           ++YGR +G   G  +N++ GLYAVLGAAS + GSMR TVSLCVI LELTNNLLLLP+ M 
Sbjct: 488 SAYGRMLGTAMGSYTNIDQGLYAVLGAASLMAGSMRMTVSLCVIFLELTNNLLLLPITMF 547

Query: 537 VLLVSKSVADVFNANIYDLIMKSKGLPYLETHAEPYMRQLTVGDV--VTGPLQIFHGYEK 594
           VLL++K+V D FN +IY++I+  KGLP+LE + EP+MR LTVG++     P+   +G EK
Sbjct: 548 VLLIAKTVGDSFNLSIYEIILHLKGLPFLEANPEPWMRNLTVGELNDAKPPVVTLNGVEK 607

Query: 595 VRNVVFVLKTTSHNGFPVIDEPPFSEAPVLFGIILRHHLLTLLRKKVFMSAP-MAMGGDV 653
           V N+V VL+ T+HN FPV+D    +    L G+ILR HL+ +L+K+ F++        +V
Sbjct: 608 VANIVDVLRNTTHNAFPVLDGADQNTGTELHGLILRAHLVKVLKKRWFLNEKRRTEEWEV 667

Query: 654 LRQFSADDFAKRGSDRGERIEDIHLTQEEMDMFIDLHPFTNASPYTVVESMSLGKALILF 713
             +F+  + A    +R +  +D+ +T  EM +++DLHP TN +PYTVV+SMS+ KAL+LF
Sbjct: 668 REKFTPVELA----EREDNFDDVAITSSEMQLYVDLHPLTNTTPYTVVQSMSVAKALVLF 723

Query: 714 RELGLRHLLVIPKIPS--RSPVVGILTRHDFTAEHILGTHPYLVRSRWKRLR 763
           R +GLRHLLV+PKI +   SPV+GILTR D  A +IL   P+L + +  + R
Sbjct: 724 RSVGLRHLLVVPKIQASGMSPVIGILTRQDLRAYNILQAFPHLDKHKSGKAR 775


>CLCD_ARATH (P92943) Chloride channel protein CLC-d (AtCLC-d)
          Length = 792

 Score =  640 bits (1650), Expect = 0.0
 Identities = 362/768 (47%), Positives = 482/768 (62%), Gaps = 38/768 (4%)

Query: 1   MSTNHLSNG-DSEHRLRQPLLSSQRSIINSSSQVAIVGANVCPIESLDYEIFENEFFKQD 59
           M +NHL NG +S++ L   +  S  +  +  + +         + SLDYE+ EN  ++++
Sbjct: 1   MLSNHLQNGIESDNLLWSRVPESDDTSTDDITLLNSHRDGDGGVNSLDYEVIENYAYREE 60

Query: 60  WRSRGSLQIFQYVLMKWLLCFLIGTILGLIGFCNNLAVENLAGVKFVVTSNMMLHKRFSL 119
              RG L +  YV +KW    LIG   GL     NL+VEN AG KF +T   ++ K +  
Sbjct: 61  QAHRGKLYVGYYVAVKWFFSLLIGIGTGLAAVFINLSVENFAGWKFALTF-AIIQKSYFA 119

Query: 120 AFVTFFASNLALTLFATIITAMIAPAAAGSGISEVKAYLNGVDAPGIFTLPTLIVKIIGS 179
            F+ +   NL L   +  I    APAAAGSGI E+K YLNG+D PG     TLI KI GS
Sbjct: 120 GFIVYLLINLVLVFSSAYIITQFAPAAAGSGIPEIKGYLNGIDIPGTLLFRTLIGKIFGS 179

Query: 180 ITAVSSSLHIGKAGPMLHTGACVAALLGQGGSKRYGLTWKWLRYFKNDRDRRDLIVCGSA 239
           I +V   L +GK GP++HTGAC+A+LLGQGGS +Y L  +W + FK+DRDRRDL+ CG A
Sbjct: 180 IGSVGGGLALGKEGPLVHTGACIASLLGQGGSTKYHLNSRWPQLFKSDRDRRDLVTCGCA 239

Query: 240 AGIAAAFRAPVGGVLFALEEMASWWRTALLWRAFFTTAIVAIFLRAMIDVCLSGKCGLFG 299
           AG+AAAFRAPVGGVLFALEE+ SWWR+ L+WR FFT+AIVA+ +R  +  C SG CG FG
Sbjct: 240 AGVAAAFRAPVGGVLFALEEVTSWWRSQLMWRVFFTSAIVAVVVRTAMGWCKSGICGHFG 299

Query: 300 KGGLIMFDAYSGSLMYHAKDVPLVFILGVIGGILGSLYNYL------WNKVLRIYNAINE 353
            GG I++D   G   Y+ K++  + ++GVIGG+LG+L+N L      W +     N++++
Sbjct: 300 GGGFIIWDVSDGQDDYYFKELLPMAVIGVIGGLLGALFNQLTLYMTSWRR-----NSLHK 354

Query: 354 KGTICKILLACVISMFTSCLLFGLPWLASCQPCP---ADPVEPCP-TIGRSGIYKKFQC- 408
           KG   KI+ AC+IS  TS + FGLP L  C PCP    D    CP   G  G Y  F C 
Sbjct: 355 KGNRVKIIEACIISCITSAISFGLPLLRKCSPCPESVPDSGIECPRPPGMYGNYVNFFCK 414

Query: 409 PPGHYNDLASLIFNTNDDAIRNLFSKNTDSEFQYSSMFIFFITGFFLSILSCGVVVPAGV 468
               YNDLA++ FNT DDAIRNLFS  T  EF   S+  F    + L++++ G  VPAG 
Sbjct: 415 TDNEYNDLATIFFNTQDDAIRNLFSAKTMREFSAQSLLTFLAMFYTLAVVTFGTAVPAGQ 474

Query: 469 FVPIIVTGASYGRFVGML---FGKKSNLNHGLYAVLGAASFLGGSMRTTVSLCVIILELT 525
           FVP I+ G++YGR VGM    F KK N+  G YA+LGAASFLGGSMR TVSLCVI++E+T
Sbjct: 475 FVPGIMIGSTYGRLVGMFVVRFYKKLNIEEGTYALLGAASFLGGSMRMTVSLCVIMVEIT 534

Query: 526 NNLLLLPLIMMVLLVSKSVADVFNANIYDLIMKSKGLPYLETHAEPYMRQLTVGD----- 580
           NNL LLPLIM+VLL+SK+V D FN  +Y++  + KG+P LE+  + +MRQ+   +     
Sbjct: 535 NNLKLLPLIMLVLLISKAVGDAFNEGLYEVQARLKGIPLLESRPKYHMRQMIAKEACQSQ 594

Query: 581 -VVTGPLQIFHGYEKVRNVVFVLKTTSHNGFPVIDEPPFSEAPVLFGIILRHHLLTLLRK 639
            V++ P  I     +V +V  +L +  HNGFPVID     E  V+ G++LR HLL LL+ 
Sbjct: 595 KVISLPRVI-----RVADVASILGSNKHNGFPVIDHTRSGETLVI-GLVLRSHLLVLLQS 648

Query: 640 KV-FMSAPMAMGGDVLR-QFSADDFAKRGSDRGERIEDIHLTQEEMDMFIDLHPFTNASP 697
           KV F  +P+         + S  +FAK  S +G  IEDIHLT ++++M+IDL PF N SP
Sbjct: 649 KVDFQHSPLPCDPSARNIRHSFSEFAKPVSSKGLCIEDIHLTSDDLEMYIDLAPFLNPSP 708

Query: 698 YTVVESMSLGKALILFRELGLRHLLVIPKIPSRSPVVGILTRHDFTAE 745
           Y V E MSL K   LFR+LGLRHL V+P+ PSR  V+G++TR D   E
Sbjct: 709 YVVPEDMSLTKVYNLFRQLGLRHLFVVPR-PSR--VIGLITRKDLLIE 753


>CLC7_HUMAN (P51798) Chloride channel protein 7 (ClC-7)
          Length = 805

 Score =  404 bits (1038), Expect = e-112
 Identities = 255/718 (35%), Positives = 400/718 (55%), Gaps = 31/718 (4%)

Query: 44  ESLDYEIFENEFFKQDWRSRGSLQIFQYVLMKWLLCFLIGTILGLIGFCNNLAVENLAGV 103
           ESLDY+  EN+ F ++ R           + +W++C LIG + GL+    ++ VENLAG+
Sbjct: 95  ESLDYDNSENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLVACFIDIVVENLAGL 154

Query: 104 KF-VVTSNMMLHKR---FSLAFVTFFASNLALTLFATIITAMIAPAAAGSGISEVKAYLN 159
           K+ V+  N+         S + + +   N A  L  ++I A I P AAGSGI ++K +LN
Sbjct: 155 KYRVIKGNIDKFTEKGGLSFSLLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFLN 214

Query: 160 GVDAPGIFTLPTLIVKIIGSITAVSSSLHIGKAGPMLHTGACVAALLGQGGSKRYGLTWK 219
           GV  P +  L TL++K+ G I +V   L +GK GPM+H+G+ +AA + QG S      +K
Sbjct: 215 GVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFK 274

Query: 220 WLRYFKNDRDRRDLIVCGSAAGIAAAFRAPVGGVLFALEEMASWWRTALLWRAFFTTAIV 279
              YF+ D ++RD +  G+AAG++AAF APVGGVLF+LEE AS+W   L WR FF + I 
Sbjct: 275 IFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMIS 334

Query: 280 AIFLRAMIDVCLSGKCGLFGKGGLIMFDAY-SGSLMYHAKDVPLVFILGVIGGILGSLYN 338
              L  ++ +   G        GLI F  + S  + Y   ++P+   +GV+GG+LG+++N
Sbjct: 335 TFTLNFVLSI-YHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFN 393

Query: 339 YLWNKVLRIYNAINEKGTICKILLACVISMFTSCLLFGLPWLA-SCQPCPADPVEPCPTI 397
            L N  L ++          +++ A +++  T+ + F L + +  CQP            
Sbjct: 394 AL-NYWLTMFRIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDCQPLQG--------- 443

Query: 398 GRSGIYKKFQCPPGHYNDLASLIFNTNDDAIRNLFSKNTDSEFQYSSMFIFFITGFFLSI 457
           G      +  C  G YN +A+  FNT + ++ +LF  +    +   ++ +F +  FFL+ 
Sbjct: 444 GSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLF-HDPPGSYNPLTLGLFTLVYFFLAC 502

Query: 458 LSCGVVVPAGVFVPIIVTGASYGRFVGM----LFGKKSNLNHGLYAVLGAASFLGGSMRT 513
            + G+ V AGVF+P ++ GA++GR  G+    L G     + G YA++GAA+ LGG +R 
Sbjct: 503 WTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAIWADPGKYALMGAAAQLGGIVRM 562

Query: 514 TVSLCVIILELTNNLLLLPLIMMVLLVSKSVADVFNANIYDLIMKSKGLPYLETHAEPYM 573
           T+SL VI++E T+N+     IM+VL+ +K V DVF   +YD+ ++ + +P+L   A    
Sbjct: 563 TLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLHWEAPVTS 622

Query: 574 RQLTVGDVVTGPLQIFHGYEKVRNVVFVLKTT--SHNGFPVIDEPPFSEAPVLFGIILRH 631
             LT  +V++ P+      EKV  +V VL  T  +HNGFPV++    ++   L G+ILR 
Sbjct: 623 HSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRS 682

Query: 632 HLLTLLRKKVFMSAPMAMGGDVLRQFSADDFAKRGSDRGERIEDIHLTQEEMDMFIDLHP 691
            L+ LL+ KVF+       G V R+    DF +    R   I+ IH++Q+E +  +DL  
Sbjct: 683 QLIVLLKHKVFVERSNL--GLVQRRLRLKDF-RDAYPRFPPIQSIHVSQDERECTMDLSE 739

Query: 692 FTNASPYTVVESMSLGKALILFRELGLRHLLVIPKIPSRSPVVGILTRHDFTAEHILG 749
           F N SPYTV +  SL +   LFR LGLRHL+V   + +R+ VVG++TR D  A + LG
Sbjct: 740 FMNPSPYTVPQEASLPRVFKLFRALGLRHLVV---VDNRNQVVGLVTRKDL-ARYRLG 793


>CLC7_RAT (P51799) Chloride channel protein 7 (ClC-7)
          Length = 803

 Score =  402 bits (1033), Expect = e-111
 Identities = 257/719 (35%), Positives = 403/719 (55%), Gaps = 33/719 (4%)

Query: 44  ESLDYEIFENEFFKQDWRSRGSLQIFQYVLMKWLLCFLIGTILGLIGFCNNLAVENLAGV 103
           ESLDY+  EN+ F ++ R           + +W++C LIG + GL+    ++ VENLAG+
Sbjct: 93  ESLDYDNSENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLVACFIDIVVENLAGL 152

Query: 104 KF-VVTSNMMLHKR---FSLAFVTFFASNLALTLFATIITAMIAPAAAGSGISEVKAYLN 159
           K+ V+  N+         S + + +   N A  L  ++I A I P AAGSGI ++K +LN
Sbjct: 153 KYRVIKDNIDKFTEKGGLSFSLLLWATLNSAFVLVGSVIVAFIEPVAAGSGIPQIKCFLN 212

Query: 160 GVDAPGIFTLPTLIVKIIGSITAVSSSLHIGKAGPMLHTGACVAALLGQGGSKRYGLTWK 219
           GV  P +  L TL++K+ G I +V   L +GK GPM+H+G+ +AA + QG S      +K
Sbjct: 213 GVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFK 272

Query: 220 WLRYFKNDRDRRDLIVCGSAAGIAAAFRAPVGGVLFALEEMASWWRTALLWRAFFTTAIV 279
              YF+ D ++RD +  G+AAG++AAF APVGGVLF+LEE AS+W   L WR FF + I 
Sbjct: 273 IFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMIS 332

Query: 280 AIFLRAMIDVCLSGKCGLFGKGGLIMFDAY-SGSLMYHAKDVPLVFILGVIGGILGSLYN 338
              L  ++ +   G        GLI F  + S  + Y   ++P+   +GV+GGILG+++N
Sbjct: 333 TFTLNFVLSI-YHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGILGAVFN 391

Query: 339 YLWNKVLRIYNAINEKGTICKILLACVISMFTSCLLFGLPWLA-SCQPCPADPVEPCPTI 397
            L N  L ++          +++ A +++  T+ + F L + +  CQP            
Sbjct: 392 AL-NYWLTMFRIRYIHRPCLQVIEAMLVAAVTATVAFVLIYSSRDCQPLQ---------- 440

Query: 398 GRSGIYK-KFQCPPGHYNDLASLIFNTNDDAIRNLFSKNTDSEFQYSSMFIFFITGFFLS 456
           G S  Y  +  C  G YN +A+  FNT + ++ +LF  +    +   ++ +F +  FFL+
Sbjct: 441 GSSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLF-HDPPGSYNPMTLGLFTLVYFFLA 499

Query: 457 ILSCGVVVPAGVFVPIIVTGASYGRFVGM----LFGKKSNLNHGLYAVLGAASFLGGSMR 512
             + G+ V AGVF+P ++ GA++GR  G+    L G     + G YA++GAA+ LGG +R
Sbjct: 500 CWTYGLTVSAGVFIPSLLIGAAWGRLFGISMSYLTGAAIWADPGKYALMGAAAQLGGIVR 559

Query: 513 TTVSLCVIILELTNNLLLLPLIMMVLLVSKSVADVFNANIYDLIMKSKGLPYLETHAEPY 572
            T+SL VI++E T+N+     IM+VL+ +K V DVF   +YD+ ++ + +P+L   A   
Sbjct: 560 MTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLHWEAPVT 619

Query: 573 MRQLTVGDVVTGPLQIFHGYEKVRNVVFVLKTT--SHNGFPVIDEPPFSEAPVLFGIILR 630
              LT  +V++ P+      EKV  +V VL  T  +HNGFPV+++   ++   L G+ILR
Sbjct: 620 SHSLTAREVMSTPVTCLRRREKVGIIVDVLSDTASNHNGFPVVEDVGDTQPARLQGLILR 679

Query: 631 HHLLTLLRKKVFMSAPMAMGGDVLRQFSADDFAKRGSDRGERIEDIHLTQEEMDMFIDLH 690
             L+ LL+ KVF+    +  G V R+    DF +    R   I+ IH++Q+E +  +DL 
Sbjct: 680 SQLIVLLKHKVFVE--RSNMGLVQRRLRLKDF-RDAYPRFPPIQSIHVSQDERECTMDLS 736

Query: 691 PFTNASPYTVVESMSLGKALILFRELGLRHLLVIPKIPSRSPVVGILTRHDFTAEHILG 749
            F N SPYTV +  SL +   LFR LGLRHL+V   + + + VVG++TR D  A + LG
Sbjct: 737 EFMNPSPYTVPQEASLPRVFKLFRALGLRHLVV---VDNHNQVVGLVTRKDL-ARYRLG 791


>CLC7_MOUSE (O70496) Chloride channel protein 7 (ClC-7)
          Length = 803

 Score =  402 bits (1033), Expect = e-111
 Identities = 257/719 (35%), Positives = 403/719 (55%), Gaps = 33/719 (4%)

Query: 44  ESLDYEIFENEFFKQDWRSRGSLQIFQYVLMKWLLCFLIGTILGLIGFCNNLAVENLAGV 103
           ESLDY+  EN+ F ++ R           + +W++C LIG + GL+    ++ VENLAG+
Sbjct: 93  ESLDYDNSENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLVACFIDIVVENLAGL 152

Query: 104 KF-VVTSNMMLHKR---FSLAFVTFFASNLALTLFATIITAMIAPAAAGSGISEVKAYLN 159
           K+ V+  N+         S + + +   N A  L  ++I A I P AAGSGI ++K +LN
Sbjct: 153 KYRVIKDNIDKFTEKGGLSFSLLLWATLNSAFVLVGSVIVAFIEPVAAGSGIPQIKCFLN 212

Query: 160 GVDAPGIFTLPTLIVKIIGSITAVSSSLHIGKAGPMLHTGACVAALLGQGGSKRYGLTWK 219
           GV  P +  L TL++K+ G I +V   L +GK GPM+H+G+ +AA + QG S      +K
Sbjct: 213 GVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFK 272

Query: 220 WLRYFKNDRDRRDLIVCGSAAGIAAAFRAPVGGVLFALEEMASWWRTALLWRAFFTTAIV 279
              YF+ D ++RD +  G+AAG++AAF APVGGVLF+LEE AS+W   L WR FF + I 
Sbjct: 273 IFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMIS 332

Query: 280 AIFLRAMIDVCLSGKCGLFGKGGLIMFDAY-SGSLMYHAKDVPLVFILGVIGGILGSLYN 338
              L  ++ +   G        GLI F  + S  + Y   ++P+   +GV+GGILG+++N
Sbjct: 333 TFTLNFVLSI-YHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGILGAVFN 391

Query: 339 YLWNKVLRIYNAINEKGTICKILLACVISMFTSCLLFGLPWLA-SCQPCPADPVEPCPTI 397
            L N  L ++          +++ A +++  T+ + F L + +  CQP            
Sbjct: 392 AL-NYWLTMFRIRYIHRPCLQVIEAMLVAAVTATVAFVLIYSSRDCQPLQ---------- 440

Query: 398 GRSGIYK-KFQCPPGHYNDLASLIFNTNDDAIRNLFSKNTDSEFQYSSMFIFFITGFFLS 456
           G S  Y  +  C  G YN +A+  FNT + ++ +LF  +    +   ++ +F +  FFL+
Sbjct: 441 GSSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLF-HDPPGSYNPMTLGLFTLVYFFLA 499

Query: 457 ILSCGVVVPAGVFVPIIVTGASYGRFVGM----LFGKKSNLNHGLYAVLGAASFLGGSMR 512
             + G+ V AGVF+P ++ GA++GR  G+    L G     + G YA++GAA+ LGG +R
Sbjct: 500 CWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAIWADPGKYALMGAAAQLGGIVR 559

Query: 513 TTVSLCVIILELTNNLLLLPLIMMVLLVSKSVADVFNANIYDLIMKSKGLPYLETHAEPY 572
            T+SL VI++E T+N+     IM+VL+ +K V DVF   +YD+ ++ + +P+L   A   
Sbjct: 560 MTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLHWEAPVT 619

Query: 573 MRQLTVGDVVTGPLQIFHGYEKVRNVVFVLKTT--SHNGFPVIDEPPFSEAPVLFGIILR 630
              LT  +V++ P+      EKV  +V VL  T  +HNGFPV+++   ++   L G+ILR
Sbjct: 620 SHSLTAREVMSTPVTCLRRREKVGIIVDVLSDTASNHNGFPVVEDVGDTQPARLQGLILR 679

Query: 631 HHLLTLLRKKVFMSAPMAMGGDVLRQFSADDFAKRGSDRGERIEDIHLTQEEMDMFIDLH 690
             L+ LL+ KVF+    +  G V R+    DF +    R   I+ IH++Q+E +  +DL 
Sbjct: 680 SQLIVLLKHKVFVE--RSNMGLVQRRLRLKDF-RDAYPRFPPIQSIHVSQDERECTMDLS 736

Query: 691 PFTNASPYTVVESMSLGKALILFRELGLRHLLVIPKIPSRSPVVGILTRHDFTAEHILG 749
            F N SPYTV +  SL +   LFR LGLRHL+V   + + + VVG++TR D  A + LG
Sbjct: 737 EFMNPSPYTVPQEASLPRVFKLFRALGLRHLVV---VDNHNQVVGLVTRKDL-ARYRLG 791


>CLC6_HUMAN (P51797) Chloride channel protein 6 (ClC-6)
          Length = 869

 Score =  328 bits (842), Expect = 3e-89
 Identities = 206/605 (34%), Positives = 326/605 (53%), Gaps = 26/605 (4%)

Query: 44  ESLDYEIFENEFFKQDWRSRGSLQIFQYVLMKWLLCFLIGTILGLIGFCNNLAVENLAGV 103
           ESLDY+   N+ + +   +  + +  +Y  +KW++ F IG   GL+G   +  V     +
Sbjct: 49  ESLDYDRCINDPYLEVLETMDNKKGRRYEAVKWMVVFAIGVCTGLVGLFVDFFVRLFTQL 108

Query: 104 KFVVTSNMMLHKR----FSLAFVTFFASNLALTLFATIITAMIAPAAAGSGISEVKAYLN 159
           KF V    +         +L+ +     NL     A+++  +I P AAGSGI EVK YLN
Sbjct: 109 KFGVVQTSVEECSQKGCLALSLLELLGFNLTFVFLASLLV-LIEPVAAGSGIPEVKCYLN 167

Query: 160 GVDAPGIFTLPTLIVKIIGSITAVSSSLHIGKAGPMLHTGACVAALLGQGGSKRYGLTWK 219
           GV  PGI  L TL+ K++G + +V+  L +GK GPM+H+G+ V A L Q  S        
Sbjct: 168 GVKVPGIVRLRTLLCKVLGVLFSVAGGLFVGKEGPMIHSGSVVGAGLPQFQSISLRKIQF 227

Query: 220 WLRYFKNDRDRRDLIVCGSAAGIAAAFRAPVGGVLFALEEMASWWRTALLWRAFFTTAIV 279
              YF++DRD+RD +  G+AAG+AAAF AP+GG LF+LEE +S+W   L W+  F +   
Sbjct: 228 NFPYFRSDRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSMSA 287

Query: 280 AIFLRAMIDVCLSGKCGLFGKGGLIMFDAYSGS------LMYHAKDVPLVFILGVIGGIL 333
              L         G  G F   GL+ F  +  S       ++ A D+    ++GVIGG+L
Sbjct: 288 TFTLNFFRSGIQFGSWGSFQLPGLLNFGEFKCSDSDKKCHLWTAMDLGFFVVMGVIGGLL 347

Query: 334 GSLYNYLWNKVLRIYNA--INEKGTICKILLACVISMFTSCLLFGLPW-LASCQPCPA-- 388
           G+ +N L NK L  Y    ++ K  + ++L + ++S+ T+ ++F     L  C+   +  
Sbjct: 348 GATFNCL-NKRLAKYRMRNVHPKPKLVRVLESLLVSLVTTVVVFVASMVLGECRQMSSSS 406

Query: 389 ----DPVEPCPTIGRSGIYKKFQCPPGHYNDLASLIFNTNDDAIRNLFSKNTDSEFQYSS 444
               D  +   T   +   K F CP   YND+A+L FN  + AI  LF +  D  F   +
Sbjct: 407 QIGNDSFQLQVTEDVNSSIKTFFCPNDTYNDMATLFFNPQESAILQLFHQ--DGTFSPVT 464

Query: 445 MFIFFITGFFLSILSCGVVVPAGVFVPIIVTGASYGRFVGMLFGKKSNLNH---GLYAVL 501
           + +FF+  F L+  + G+ VP+G+FVP ++ GA++GR V  +      L H   G +A++
Sbjct: 465 LALFFVLYFLLACWTYGISVPSGLFVPSLLCGAAFGRLVANVLKSYIGLGHIYSGTFALI 524

Query: 502 GAASFLGGSMRTTVSLCVIILELTNNLLLLPLIMMVLLVSKSVADVFNANIYDLIMKSKG 561
           GAA+FLGG +R T+SL VI++E TN +     IM+ L+V+K   D FN  IYD+ +  +G
Sbjct: 525 GAAAFLGGVVRMTISLTVILIESTNEITYGLPIMVTLMVAKWTGDFFNKGIYDIHVGLRG 584

Query: 562 LPYLETHAEPYMRQLTVGDVVTGPLQIFHGYEKVRNVVFVLKTTSHNGFPVIDEPPFSEA 621
           +P LE   E  M +L   D++   L   + + +++++V +L+TT H+ FPV+ E   +E 
Sbjct: 585 VPLLEWETEVEMDKLRASDIMEPNLTYVYPHTRIQSLVSILRTTVHHAFPVVTENRGNEK 644

Query: 622 PVLFG 626
             + G
Sbjct: 645 EFMKG 649



 Score = 64.7 bits (156), Expect = 9e-10
 Identities = 44/129 (34%), Positives = 68/129 (52%), Gaps = 11/129 (8%)

Query: 622 PVLF-GIILRHHLLTLLRKKVFMSAPMAMGGDVLRQFS--ADDFAKRGSDRGERIEDIHL 678
           P+ F G+ILR  L+TLL + V  S   +        ++  A+D+      R   I D+ L
Sbjct: 738 PLTFHGLILRSQLVTLLVRGVCYSESQSSASQPRLSYAEMAEDYP-----RYPDIHDLDL 792

Query: 679 TQEEMDMFIDLHPFTNASPYTVVESMSLGKALILFRELGLRHLLVIPKIPSRSPVVGILT 738
           T     M +D+ P+ N SP+TV  +  + +   LFR +GLRHL   P + +   +VGI+T
Sbjct: 793 TLLNPRMIVDVTPYMNPSPFTVSPNTHVSQVFNLFRTMGLRHL---PVVNAVGEIVGIIT 849

Query: 739 RHDFTAEHI 747
           RH+ T E +
Sbjct: 850 RHNLTYEFL 858


>CLC6_MOUSE (O35454) Chloride channel protein 6 (ClC-6)
          Length = 870

 Score =  326 bits (836), Expect = 1e-88
 Identities = 205/606 (33%), Positives = 325/606 (52%), Gaps = 27/606 (4%)

Query: 44  ESLDYEIFENEFFKQDWRSRGSLQIFQYVLMKWLLCFLIGTILGLIGFCNNLAVENLAGV 103
           ESLDY+   N+ + +   +  + +  +Y  +KW++ F IG   GL+G   + +V     +
Sbjct: 49  ESLDYDRCINDPYLEVLETMDNKKGRRYEAVKWMVVFAIGVCTGLVGLFVDFSVRLFTQL 108

Query: 104 KFVVTSNMMLHKR----FSLAFVTFFASNLALTLFATIITAMIAPAAAGSGISEVKAYLN 159
           KF V    +         +L+ +     NL     A+++  +I P AAGSGI E+K YLN
Sbjct: 109 KFGVVQTSVEECSQKGCLALSLLELLGFNLTFVFLASLLV-LIEPVAAGSGIPEIKCYLN 167

Query: 160 GVDAPGIFTLPTLIVKIIGSITAVSSSLHIGKAGPMLHTGACVAALLGQGGSKRYGLTWK 219
           GV  PGI  L TL+ K+ G + +VS  L +GK GPM+H+GA V A L Q  S        
Sbjct: 168 GVKVPGIVRLRTLLCKVFGVLFSVSGGLFVGKEGPMIHSGAVVGAGLPQFQSISLRKIQF 227

Query: 220 WLRYFKNDRDRRDLIVCGSAAGIAAAFRAPVGGVLFALEEMASWWRTALLWRAFFTTAIV 279
              YF++DRD+RD +  G+AAG+AAAF AP+GG LF+LEE +S+W   L W+  F +   
Sbjct: 228 NFPYFRSDRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSMSA 287

Query: 280 AIFLRAMIDVCLSGKCGLFGKGGLIMFDAYSGS------LMYHAKDVPLVFILGVIGGIL 333
              L         G  G F   GL+ F  +  S       ++ A D+    ++GVIGG+L
Sbjct: 288 TFTLNFFRSGIQFGSWGSFQLPGLLNFGEFKCSDSDKKCHLWTAMDLGFFVVMGVIGGLL 347

Query: 334 GSLYNYLWNKVLRIYNA--INEKGTICKILLACVISMFTSCLLFGLPW-LASCQPCPADP 390
           G+ +N L NK L  Y    ++ K  + ++L + ++S+ T+ ++F     L  C+   +  
Sbjct: 348 GATFNCL-NKRLAKYRMRNVHPKPKLVRVLESLLVSLVTTVVVFVASMVLGECRQMSSTS 406

Query: 391 VE-------PCPTIGRSGIYKKFQCPPGHYNDLASLIFNTNDDAIRNLFSKNTDSEFQYS 443
                       +   +   K F CP   YND+A+L FN+ + AI  LF +  D  F   
Sbjct: 407 QTGNGSFQLQVTSEDVNSTIKAFFCPNDTYNDMATLFFNSQESAILQLFHQ--DGTFSPV 464

Query: 444 SMFIFFITGFFLSILSCGVVVPAGVFVPIIVTGASYGRFVGMLFGKKSNLNH---GLYAV 500
           ++ +FFI  F L+  + G  VP+G+FVP ++ GA++GR V  +      L H   G +A+
Sbjct: 465 TLALFFILYFLLACWTFGTSVPSGLFVPSLLCGAAFGRLVANVLKSYIGLGHLYSGTFAL 524

Query: 501 LGAASFLGGSMRTTVSLCVIILELTNNLLLLPLIMMVLLVSKSVADVFNANIYDLIMKSK 560
           +GAA+FLGG +R T+SL VI++E TN +     IM+ L+V+K   D+FN  IYD+ +  +
Sbjct: 525 IGAAAFLGGVVRMTISLTVILIESTNEITYGLPIMVTLMVAKWTGDLFNKGIYDVHIGLR 584

Query: 561 GLPYLETHAEPYMRQLTVGDVVTGPLQIFHGYEKVRNVVFVLKTTSHNGFPVIDEPPFSE 620
           G+P LE   +  M +L   D++   L   + + +++++V +L+TT H+ FPV+ E   +E
Sbjct: 585 GVPLLEWETDVEMDKLRASDIMEPNLTYVYPHTRIQSLVSILRTTVHHAFPVVTENRGNE 644

Query: 621 APVLFG 626
              + G
Sbjct: 645 KEFMKG 650



 Score = 64.3 bits (155), Expect = 1e-09
 Identities = 43/129 (33%), Positives = 68/129 (52%), Gaps = 11/129 (8%)

Query: 622 PVLF-GIILRHHLLTLLRKKVFMSAPMAMGGDVLRQFS--ADDFAKRGSDRGERIEDIHL 678
           P+ F G++LR  L+TLL + V  S   +        ++  A+D+      R   I D+ L
Sbjct: 739 PLTFHGLVLRSQLVTLLVRGVCYSESQSSASQPRLSYAEMAEDYP-----RYPDIHDLDL 793

Query: 679 TQEEMDMFIDLHPFTNASPYTVVESMSLGKALILFRELGLRHLLVIPKIPSRSPVVGILT 738
           T     M +D+ P+ N SP+TV  +  + +   LFR +GLRHL   P + +   +VGI+T
Sbjct: 794 TLLNPRMIVDVTPYMNPSPFTVSPNTHVSQVFNLFRTMGLRHL---PVVNAVGEIVGIIT 850

Query: 739 RHDFTAEHI 747
           RH+ T E +
Sbjct: 851 RHNLTNEFL 859


>CLC6_RABIT (Q9TT16) Chloride channel protein 6 (ClC-6)
          Length = 869

 Score =  320 bits (819), Expect = 1e-86
 Identities = 203/605 (33%), Positives = 323/605 (52%), Gaps = 26/605 (4%)

Query: 44  ESLDYEIFENEFFKQDWRSRGSLQIFQYVLMKWLLCFLIGTILGLIGFCNNLAVENLAGV 103
           ESLDY+   N+ + +   +    +   Y ++KW + F IG   GL+G   +  V+    +
Sbjct: 49  ESLDYDRCINDPYLEVLETMDHKKGRWYEVVKWTVVFAIGVCTGLVGLFVDFFVQLFTQL 108

Query: 104 KFVVTSNMMLHKR----FSLAFVTFFASNLALTLFATIITAMIAPAAAGSGISEVKAYLN 159
           KF V    +         +L+ +     NL     A+++  +I P AAGSGI E+K YLN
Sbjct: 109 KFGVVEASVEECSQKGCLALSLLELLGFNLTFVFLASLLV-LIEPVAAGSGIPEIKCYLN 167

Query: 160 GVDAPGIFTLPTLIVKIIGSITAVSSSLHIGKAGPMLHTGACVAALLGQGGSKRYGLTWK 219
           GV  PGI  L TL+ K+ G + +V+  L +GK GPM+H+GA V A L Q  S        
Sbjct: 168 GVKVPGIVRLRTLLCKVFGVLFSVAGGLFVGKEGPMIHSGAVVGAGLPQFQSISLRKIQF 227

Query: 220 WLRYFKNDRDRRDLIVCGSAAGIAAAFRAPVGGVLFALEEMASWWRTALLWRAFFTTAIV 279
              YF++DRD+RD +  G+AAGIAAAF AP+G  LF+LEE +S+W   L W+  F +   
Sbjct: 228 NFPYFRSDRDKRDFVSAGAAAGIAAAFGAPIGATLFSLEEGSSFWNQGLTWKVLFCSMSA 287

Query: 280 AIFLRAMIDVCLSGKCGLFGKGGLIMFDAYSGS------LMYHAKDVPLVFILGVIGGIL 333
              L         G  G F   GL+ F  +  S       ++ A D+    ++GVIGG+L
Sbjct: 288 TFTLNFFRSGIQFGSWGSFQLPGLLNFGEFKCSDSDKKCHLWTAMDMGFFVVMGVIGGLL 347

Query: 334 GSLYNYLWNKVLRIYNA--INEKGTICKILLACVISMFTSCLLFGLPW-LASCQPCPADP 390
           G+ +N L NK L  Y    ++ K  + ++L + ++S+ T+ ++F     L  C+   +  
Sbjct: 348 GATFNCL-NKRLAKYRMRNVHPKPKLVRVLESLLVSLVTTLVVFVASMVLGECRQMSSSS 406

Query: 391 ------VEPCPTIGRSGIYKKFQCPPGHYNDLASLIFNTNDDAIRNLFSKNTDSEFQYSS 444
                 ++   T   +   K F CP   YND+A+L FN  + AI  LF +  D  F   +
Sbjct: 407 QISNGSLKLQVTSDVNSSIKAFFCPNDTYNDMATLFFNPQESAILQLFHQ--DGTFSPIT 464

Query: 445 MFIFFITGFFLSILSCGVVVPAGVFVPIIVTGASYGRFVGMLFGKKSNLNH---GLYAVL 501
           + +FF+  F L+  + G+ VP+G+FVP ++ GA++GR V  +      L+H   G ++++
Sbjct: 465 LALFFVLYFLLACWTYGISVPSGLFVPSLLCGAAFGRLVANVLKSYIGLSHIYSGTFSLI 524

Query: 502 GAASFLGGSMRTTVSLCVIILELTNNLLLLPLIMMVLLVSKSVADVFNANIYDLIMKSKG 561
           GAA+ LGG +R T+SL VI++E TN +     IM+ L+V+K   D FN  IYD+ +  +G
Sbjct: 525 GAAALLGGVVRMTISLTVILIESTNEITYGLPIMITLMVAKWTGDFFNKGIYDIHVGLRG 584

Query: 562 LPYLETHAEPYMRQLTVGDVVTGPLQIFHGYEKVRNVVFVLKTTSHNGFPVIDEPPFSEA 621
           +P LE   E  M +L   D++   L   + + +++++V +L+TT H+ FPV+ E   +E 
Sbjct: 585 VPLLEWETEVEMDKLRASDIMEPNLTYVYPHTRIQSLVSILRTTVHHAFPVVTENRGNEK 644

Query: 622 PVLFG 626
             + G
Sbjct: 645 EFMKG 649



 Score = 64.3 bits (155), Expect = 1e-09
 Identities = 44/129 (34%), Positives = 68/129 (52%), Gaps = 11/129 (8%)

Query: 622 PVLF-GIILRHHLLTLLRKKVFMSAPMAMGGDVLRQFS--ADDFAKRGSDRGERIEDIHL 678
           P+ F G+ILR  L+TLL + V  S   +        ++  A+D+      R   I D+ L
Sbjct: 738 PLTFHGLILRSQLVTLLVRGVCYSESQSSASQPRLSYAEMAEDYP-----RFPDIHDLDL 792

Query: 679 TQEEMDMFIDLHPFTNASPYTVVESMSLGKALILFRELGLRHLLVIPKIPSRSPVVGILT 738
           T     M +D+ P+ N SP+TV  +  + +   LFR +GLRHL   P + +   +VGI+T
Sbjct: 793 TLLNPRMIVDVTPYMNPSPFTVSPNTHVSQVFNLFRTMGLRHL---PVVNAVGEIVGIVT 849

Query: 739 RHDFTAEHI 747
           RH+ T E +
Sbjct: 850 RHNLTYEFL 858


>CLC3_HUMAN (P51790) Chloride channel protein 3 (ClC-3)
          Length = 762

 Score =  197 bits (502), Expect = 7e-50
 Identities = 173/659 (26%), Positives = 290/659 (43%), Gaps = 98/659 (14%)

Query: 117 FSLAFVTFFASNLALTLFATIITAMIAPAAAGSGISEVKAYLNGVDAPGIFTLPTLIVKI 176
           + + ++ +    L+    A  +  + AP A GSGI E+K  L+G    G     TL++K 
Sbjct: 149 YIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIKT 208

Query: 177 IGSITAVSSSLHIGKAGPMLHTGACVAALLGQGGSKRYGLTWKWLRYFKNDRDRRDLIVC 236
           I  + AV+S L +GK GP++H   C   +           ++ + +Y  N+  +R+++  
Sbjct: 209 ITLVLAVASGLSLGKEGPLVHVACCCGNIF----------SYLFPKYSTNEAKKREVLSA 258

Query: 237 GSAAGIAAAFRAPVGGVLFALEEMASWWRTALLWRAFFTTAIVAIFLRAMIDVCLSGKCG 296
            SAAG++ AF AP+GGVLF+LEE++ ++    LWR+FF   + A  LR++          
Sbjct: 259 ASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSI---------N 309

Query: 297 LFGKGGLIMFDAYSGSLMYHAKDVPLVFILGVIGGILGSLY---NYLWNKVLRIYNAINE 353
            FG   L++F     +  Y  +  P + +LGV GG+ G+ +   N  W +  +     + 
Sbjct: 310 PFGNSRLVLFYVEYHTPWYLFELFPFI-LLGVFGGLWGAFFIRANIAWCRRRK-----ST 363

Query: 354 KGTICKILLACVISMFTSCLLFGLPWLASCQPCPADPVEPCPTIGRSGIYKKF--QCPPG 411
           K     +L   +++  T+ + F  P+                 +  S + K+    C P 
Sbjct: 364 KFGKYPVLEVIIVAAITAVIAFPNPY---------------TRLNTSELIKELFTDCGPL 408

Query: 412 HYNDLASLIFNTNDDAIRNLFSKNTDSEFQYSSMF---IFFITGFFLSILSCGVVVPAGV 468
             + L     + N   I +           YS+++   +  I    +++ + G+ VP+G+
Sbjct: 409 ESSSLCDYRNDMNASKIVDDIPDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGL 468

Query: 469 FVPIIVTGASYGRFVGMLFGKKSNLNH------------------GLYAVLGAASFLGGS 510
           F+P +  GA  GR VG+   + +  +H                  GLYA++GAA+ LGG 
Sbjct: 469 FIPSMAIGAIAGRIVGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGV 528

Query: 511 MRTTVSLCVIILELTNNLLLLPLIMMVLLVSKSVADVF-NANIYDLIMKSKGLPYLETHA 569
            R TVSL VI+ ELT  L  +  +M  ++ SK V D F    IY+  ++  G P+L+   
Sbjct: 529 TRMTVSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKE 588

Query: 570 EPYMRQLTVGDVVTGPLQ-------IFHGYEKVRNVVFVLKTTSHNGFPVIDEPPFSEAP 622
           E      T+   V  P +       +      V ++  ++  TS+NGFPVI      E+ 
Sbjct: 589 EFEFTHTTLAADVMRPRRNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMS---KESQ 645

Query: 623 VLFGIILRHHLLTLLRKKVFMSAPMAMGGDVLRQFSADDFAKRGSDRGERIEDIHLTQEE 682
            L G  LR  L   +      SA     G V            GS R    +       E
Sbjct: 646 RLVGFALRRDLTIAIE-----SARKKQEGIV------------GSSRVCFAQHTPSLPAE 688

Query: 683 MDMFIDLHPFTNASPYTVVESMSLGKALILFRELGLRHLLVIPKIPSRSPVVGILTRHD 741
               + L    + SP+TV +   +   + +FR+LGLR  LV         ++GI+T+ D
Sbjct: 689 SPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGLRQCLV----THNGRLLGIITKKD 743


>CLC3_CAVPO (Q9R279) Chloride channel protein 3 (ClC-3)
          Length = 760

 Score =  197 bits (502), Expect = 7e-50
 Identities = 174/658 (26%), Positives = 291/658 (43%), Gaps = 98/658 (14%)

Query: 117 FSLAFVTFFASNLALTLFATIITAMIAPAAAGSGISEVKAYLNGVDAPGIFTLPTLIVKI 176
           + + ++ +    L+    A  +  + AP A GSGI E+K  L+G    G     TL++K 
Sbjct: 149 YIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIKT 208

Query: 177 IGSITAVSSSLHIGKAGPMLHTGACVAALLGQGGSKRYGLTWKWLRYFKNDRDRRDLIVC 236
           I  + AV+S L +GK GP++H   C   +           ++ + +Y  N+  +R+++  
Sbjct: 209 ITLVLAVASGLSLGKEGPLVHVACCCGNIF----------SYLFPKYSTNEAKKREVLSA 258

Query: 237 GSAAGIAAAFRAPVGGVLFALEEMASWWRTALLWRAFFTTAIVAIFLRAMIDVCLSGKCG 296
            SAAG++ AF AP+GGVLF+LEE++ ++    LWR+FF   + A  LR++          
Sbjct: 259 ASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSI---------N 309

Query: 297 LFGKGGLIMFDAYSGSLMYHAKDVPLVFILGVIGGILGSLY---NYLWNKVLRIYNAINE 353
            FG   L++F     +  Y  +  P + +LGV GG+ G+ +   N  W +  +     + 
Sbjct: 310 PFGNSRLVLFYVEYHTPWYLFELFPFI-LLGVFGGLWGAFFIRANIAWCRRRK-----ST 363

Query: 354 KGTICKILLACVISMFTSCLLFGLPWLASCQPCPADPVEPCPTIGRSGIYKKF--QCPPG 411
           K     +L   +++  T+ + F  P+                 +  S + K+    C P 
Sbjct: 364 KFGKYPVLEVIIVAAITAVIAFPNPY---------------TRLNTSELIKELFTDCGPL 408

Query: 412 HYNDLASLIFNTNDDAIRNLFSKNTDSEFQYSSMF---IFFITGFFLSILSCGVVVPAGV 468
             + L     + N   I +           YS+++   +  I    +++ + G+ VP+G+
Sbjct: 409 ESSSLCDYRNDMNASKIVDDIPDRPAGVGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGL 468

Query: 469 FVPIIVTGASYGRFVGMLFGKKSNLNH------------------GLYAVLGAASFLGGS 510
           F+P +  GA  GR VG+   + +  +H                  GLYA++GAA+ LGG 
Sbjct: 469 FIPSMAIGAIAGRIVGIAVEQLAYFHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGV 528

Query: 511 MRTTVSLCVIILELTNNLLLLPLIMMVLLVSKSVADVF-NANIYDLIMKSKGLPYLETHA 569
            R TVSL VI+ ELT  L  +  +M  ++ SK V D F    IY+  ++  G P+L+   
Sbjct: 529 TRMTVSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDA-K 587

Query: 570 EPYMRQLTVGDVV-----TGPLQIF-HGYEKVRNVVFVLKTTSHNGFPVIDEPPFSEAPV 623
           E +       DV+       PL +       V ++  ++  TS+NGFPVI      E+  
Sbjct: 588 EEFTHTTLAADVMRPRRNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMS---KESQR 644

Query: 624 LFGIILRHHLLTLLRKKVFMSAPMAMGGDVLRQFSADDFAKRGSDRGERIEDIHLTQEEM 683
           L G  LR  L   +      SA     G V            GS R    +       E 
Sbjct: 645 LVGFALRRDLTIAIE-----SARKKQEGIV------------GSSRVCFAQHTPSLPAES 687

Query: 684 DMFIDLHPFTNASPYTVVESMSLGKALILFRELGLRHLLVIPKIPSRSPVVGILTRHD 741
              + L    + SP+TV +   +   + +FR+LGLR  LV         ++GI+T+ D
Sbjct: 688 PRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGLRQCLV----THNGRLLGIITKKD 741


>CLC3_MOUSE (P51791) Chloride channel protein 3 (ClC-3)
          Length = 760

 Score =  197 bits (501), Expect = 9e-50
 Identities = 174/658 (26%), Positives = 291/658 (43%), Gaps = 98/658 (14%)

Query: 117 FSLAFVTFFASNLALTLFATIITAMIAPAAAGSGISEVKAYLNGVDAPGIFTLPTLIVKI 176
           + + ++ +    L+    A  +  + AP A GSGI E+K  L+G    G     TL++K 
Sbjct: 149 YIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIKT 208

Query: 177 IGSITAVSSSLHIGKAGPMLHTGACVAALLGQGGSKRYGLTWKWLRYFKNDRDRRDLIVC 236
           I  + AV+S L +GK GP++H   C   +           ++ + +Y  N+  +R+++  
Sbjct: 209 ITLVLAVASGLSLGKEGPLVHVACCCGNIF----------SYLFPKYSTNEAKKREVLSA 258

Query: 237 GSAAGIAAAFRAPVGGVLFALEEMASWWRTALLWRAFFTTAIVAIFLRAMIDVCLSGKCG 296
            SAAG++ AF AP+GGVLF+LEE++ ++    LWR+FF   + A  LR++          
Sbjct: 259 ASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSI---------N 309

Query: 297 LFGKGGLIMFDAYSGSLMYHAKDVPLVFILGVIGGILGSLY---NYLWNKVLRIYNAINE 353
            FG   L++F     +  Y  +  P + +LGV GG+ G+ +   N  W +  +     + 
Sbjct: 310 PFGNSRLVLFYVEYHTPWYLFELFPFI-LLGVFGGLWGAFFIRANIAWCRRRK-----ST 363

Query: 354 KGTICKILLACVISMFTSCLLFGLPWLASCQPCPADPVEPCPTIGRSGIYKKF--QCPPG 411
           K     +L   +++  T+ + F  P+                 +  S + K+    C P 
Sbjct: 364 KFGKYPVLEVIIVAAITAVIAFPNPY---------------TRLNTSELIKELFTDCGPL 408

Query: 412 HYNDLASLIFNTNDDAIRNLFSKNTDSEFQYSSMF---IFFITGFFLSILSCGVVVPAGV 468
             + L     + N   I +           YS+++   +  I    +++ + G+ VP+G+
Sbjct: 409 ESSSLCDYRNDMNASKIVDDIPDRPAGVGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGL 468

Query: 469 FVPIIVTGASYGRFVGMLFGKKSNLNH------------------GLYAVLGAASFLGGS 510
           F+P +  GA  GR VG+   + +  +H                  GLYA++GAA+ LGG 
Sbjct: 469 FIPSMAIGAIAGRIVGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGV 528

Query: 511 MRTTVSLCVIILELTNNLLLLPLIMMVLLVSKSVADVF-NANIYDLIMKSKGLPYLETHA 569
            R TVSL VI+ ELT  L  +  +M  ++ SK V D F    IY+  ++  G P+L+   
Sbjct: 529 TRMTVSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDA-K 587

Query: 570 EPYMRQLTVGDVV-----TGPLQIF-HGYEKVRNVVFVLKTTSHNGFPVIDEPPFSEAPV 623
           E +       DV+       PL +       V ++  ++  TS+NGFPVI      E+  
Sbjct: 588 EEFTHTTLAADVMRPRRSDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMS---KESQR 644

Query: 624 LFGIILRHHLLTLLRKKVFMSAPMAMGGDVLRQFSADDFAKRGSDRGERIEDIHLTQEEM 683
           L G  LR  L   +      SA     G V            GS R    +       E 
Sbjct: 645 LVGFALRRDLTIAIE-----SARKKQEGIV------------GSSRVCFAQHTPSLPAES 687

Query: 684 DMFIDLHPFTNASPYTVVESMSLGKALILFRELGLRHLLVIPKIPSRSPVVGILTRHD 741
              + L    + SP+TV +   +   + +FR+LGLR  LV         ++GI+T+ D
Sbjct: 688 PRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGLRQCLV----THNGRLLGIITKKD 741


>CLC3_RAT (P51792) Chloride channel protein 3 (ClC-3)
          Length = 760

 Score =  197 bits (500), Expect = 1e-49
 Identities = 174/658 (26%), Positives = 291/658 (43%), Gaps = 98/658 (14%)

Query: 117 FSLAFVTFFASNLALTLFATIITAMIAPAAAGSGISEVKAYLNGVDAPGIFTLPTLIVKI 176
           + + ++ +    L+    A  +  + AP A GSGI E+K  L+G    G     TL++K 
Sbjct: 149 YIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIKT 208

Query: 177 IGSITAVSSSLHIGKAGPMLHTGACVAALLGQGGSKRYGLTWKWLRYFKNDRDRRDLIVC 236
           I  + AV+S L +GK GP++H   C   +           ++ + +Y  N+  +R+++  
Sbjct: 209 ITLVLAVASGLSLGKEGPLVHVACCCGNIF----------SYLFPKYSTNEAKKREVLSA 258

Query: 237 GSAAGIAAAFRAPVGGVLFALEEMASWWRTALLWRAFFTTAIVAIFLRAMIDVCLSGKCG 296
            SAAG++ AF AP+GGVLF+LEE++ ++    LWR+FF   + A  LR++          
Sbjct: 259 ASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSI---------N 309

Query: 297 LFGKGGLIMFDAYSGSLMYHAKDVPLVFILGVIGGILGSLY---NYLWNKVLRIYNAINE 353
            FG   L++F     +  Y  +  P + +LGV GG+ G+ +   N  W +  +     + 
Sbjct: 310 PFGNSRLVLFYVEYHTPWYLFELFPFI-LLGVFGGLWGAFFIRANIAWCRRRK-----ST 363

Query: 354 KGTICKILLACVISMFTSCLLFGLPWLASCQPCPADPVEPCPTIGRSGIYKKF--QCPPG 411
           K     +L   +++  T+ + F  P+                 +  S + K+    C P 
Sbjct: 364 KFGKYPVLEVIIVAAITAVIAFPNPY---------------TRLNTSELIKELFTDCGPL 408

Query: 412 HYNDLASLIFNTNDDAIRNLFSKNTDSEFQYSSMF---IFFITGFFLSILSCGVVVPAGV 468
             + L     + N   I +           YS+++   +  I    +++ + G+ VP+G+
Sbjct: 409 ESSSLCDYRNDMNASKIVDDIPDRPAGVGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGL 468

Query: 469 FVPIIVTGASYGRFVGMLFGKKSNLNH------------------GLYAVLGAASFLGGS 510
           F+P +  GA  GR VG+   + +  +H                  GLYA++GAA+ LGG 
Sbjct: 469 FIPSMAIGAIAGRIVGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGV 528

Query: 511 MRTTVSLCVIILELTNNLLLLPLIMMVLLVSKSVADVF-NANIYDLIMKSKGLPYLETHA 569
            R TVSL VI+ ELT  L  +  +M  ++ SK V D F    IY+  ++  G P+L+   
Sbjct: 529 TRMTVSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDA-K 587

Query: 570 EPYMRQLTVGDVV-----TGPLQIF-HGYEKVRNVVFVLKTTSHNGFPVIDEPPFSEAPV 623
           E +       DV+       PL +       V ++  ++  TS+NGFPVI      E+  
Sbjct: 588 EEFTHTTLAADVMRPRRSDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMS---KESQR 644

Query: 624 LFGIILRHHLLTLLRKKVFMSAPMAMGGDVLRQFSADDFAKRGSDRGERIEDIHLTQEEM 683
           L G  LR  L   +      SA     G V            GS R    +       E 
Sbjct: 645 LVGFALRRDLTIAIE-----SARKKQEGVV------------GSSRVCFAQHTPSLPAES 687

Query: 684 DMFIDLHPFTNASPYTVVESMSLGKALILFRELGLRHLLVIPKIPSRSPVVGILTRHD 741
              + L    + SP+TV +   +   + +FR+LGLR  LV         ++GI+T+ D
Sbjct: 688 PRPLKLRSILDMSPFTVTDHTPMEIVVDVFRKLGLRQCLV----THNGRLLGIITKKD 741


>CLC3_RABIT (O18894) Chloride channel protein 3 (ClC-3)
          Length = 760

 Score =  197 bits (500), Expect = 1e-49
 Identities = 174/658 (26%), Positives = 291/658 (43%), Gaps = 98/658 (14%)

Query: 117 FSLAFVTFFASNLALTLFATIITAMIAPAAAGSGISEVKAYLNGVDAPGIFTLPTLIVKI 176
           + + ++ +    L+    A  +  + AP A GSGI E+K  L+G    G     TL++K 
Sbjct: 149 YIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIKT 208

Query: 177 IGSITAVSSSLHIGKAGPMLHTGACVAALLGQGGSKRYGLTWKWLRYFKNDRDRRDLIVC 236
           I  + AV+S L +GK GP++H   C   +           ++ + +Y  N+  +R+++  
Sbjct: 209 ITLVLAVASGLSLGKEGPLVHVACCCGNIF----------SYLFPKYSTNEAKKREVLSA 258

Query: 237 GSAAGIAAAFRAPVGGVLFALEEMASWWRTALLWRAFFTTAIVAIFLRAMIDVCLSGKCG 296
            SAAG++ AF AP+GGVLF+LEE++ ++    LWR+FF   + A  LR++          
Sbjct: 259 ASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSI---------N 309

Query: 297 LFGKGGLIMFDAYSGSLMYHAKDVPLVFILGVIGGILGSLY---NYLWNKVLRIYNAINE 353
            FG   L++F     +  Y  +  P + +LGV GG+ G+ +   N  W +  +     + 
Sbjct: 310 PFGNSRLVLFYVEYHTPWYLFELFPFI-LLGVFGGLWGAFFIRANIAWCRRRK-----ST 363

Query: 354 KGTICKILLACVISMFTSCLLFGLPWLASCQPCPADPVEPCPTIGRSGIYKKF--QCPPG 411
           K     +L   +++  T+ + F  P+                 +  S + K+    C P 
Sbjct: 364 KFGKYPVLEVIIVAAITAVIAFPNPY---------------TRLNTSELIKELFTDCGPL 408

Query: 412 HYNDLASLIFNTNDDAIRNLFSKNTDSEFQYSSMF---IFFITGFFLSILSCGVVVPAGV 468
             + L     + N   I +           YS+++   +  I    +++ + G+ VP+G+
Sbjct: 409 ESSSLCDYRNDMNASKIVDDIPDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGL 468

Query: 469 FVPIIVTGASYGRFVGMLFGKKSNLNH------------------GLYAVLGAASFLGGS 510
           F+P +  GA  GR VG+   + +  +H                  GLYA++GAA+ LGG 
Sbjct: 469 FIPSMAIGAIAGRIVGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGV 528

Query: 511 MRTTVSLCVIILELTNNLLLLPLIMMVLLVSKSVADVF-NANIYDLIMKSKGLPYLETHA 569
            R TVSL VI+ ELT  L  +  +M  ++ SK V D F    IY+  ++  G P+L+   
Sbjct: 529 TRMTVSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDA-K 587

Query: 570 EPYMRQLTVGDVV-----TGPLQIF-HGYEKVRNVVFVLKTTSHNGFPVIDEPPFSEAPV 623
           E +       DV+       PL +       V ++  ++  TS+NGFPVI      E+  
Sbjct: 588 EEFTHTTLAADVMRPRRNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMS---KESQR 644

Query: 624 LFGIILRHHLLTLLRKKVFMSAPMAMGGDVLRQFSADDFAKRGSDRGERIEDIHLTQEEM 683
           L G  LR  L   +      SA     G V            GS R    +       E 
Sbjct: 645 LVGFALRRDLTIAIE-----SARKKQEGIV------------GSSRVCFAQHTPSLPAES 687

Query: 684 DMFIDLHPFTNASPYTVVESMSLGKALILFRELGLRHLLVIPKIPSRSPVVGILTRHD 741
              + L    + SP+TV +   +   + +FR+LGLR  LV         ++GI+T+ D
Sbjct: 688 PRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGLRQCLV----THNGRLLGIITKKD 741


>CLC4_HUMAN (P51793) Chloride channel protein 4 (ClC-4)
          Length = 760

 Score =  192 bits (488), Expect = 3e-48
 Identities = 179/663 (26%), Positives = 291/663 (42%), Gaps = 108/663 (16%)

Query: 117 FSLAFVTFFASNLALTLFATIITAMIAPAAAGSGISEVKAYLNGVDAPGIFTLPTLIVKI 176
           + L ++ +    L     A  +  + AP A GSGI E+K  L+G    G     TL++K 
Sbjct: 149 YILNYLMYILWALLFAFLAVSLVRVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLLIKT 208

Query: 177 IGSITAVSSSLHIGKAGPMLHTGACVAALLGQGGSKRYGLTWKWLRYFKNDRDRRDLIVC 236
           +  +  VSS L +GK GP++H   C         SK          Y KN+  RR+++  
Sbjct: 209 VTLVLVVSSGLSLGKEGPLVHVACCCGNFFSSLFSK----------YSKNEGKRREVLSA 258

Query: 237 GSAAGIAAAFRAPVGGVLFALEEMASWWRTALLWRAFFTTAIVAIFLRAMIDVCLSGKCG 296
            +AAG++ AF AP+GGVLF+LEE++ ++    LWR+FF   + A  LR++          
Sbjct: 259 AAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSI---------N 309

Query: 297 LFGKGGLIMFDAYSGSLMYHAKDVPLVFILGVIGGILGSLY---NYLW---NKVLRIYNA 350
            FG   L++F     +  Y A+  P + +LGV GG+ G+L+   N  W    K  R+   
Sbjct: 310 PFGNSRLVLFYVEYHTPWYMAELFPFI-LLGVFGGLWGTLFIRCNIAWCRRRKTTRLGK- 367

Query: 351 INEKGTICKILLACVISMFTSCLLFGLPWL-ASCQPCPADPVEPCPTIGRSGIYKKFQCP 409
                    +L   V++  T+ + +  P+   S     ++    C  +  S +      P
Sbjct: 368 -------YPVLEVIVVTAITAIIAYPNPYTRQSTSELISELFNDCGALESSQLCDYINDP 420

Query: 410 PGHYNDLASLIFNTNDDAIRNLFSKNTDSEFQYSSMFIFFITGFFLSILSCGVVVPAGVF 469
                   ++    +D   R        + +Q +   IF I    ++I + G+ +P+G+F
Sbjct: 421 --------NMTRPVDDIPDRPAGVGVYTAMWQLALALIFKIV---VTIFTFGMKIPSGLF 469

Query: 470 VPIIVTGASYGRFVGMLFGKKSNLNH------------------GLYAVLGAASFLGGSM 511
           +P +  GA  GR VG+   + +  +H                  GLYA++GAA+ LGG  
Sbjct: 470 IPSMAVGAIAGRMVGIGVEQLAYHHHDWIIFRNWCRPGADCVTPGLYAMVGAAACLGGVT 529

Query: 512 RTTVSLCVIILELTNNLLLLPLIMMVLLVSKSVADVF-NANIYDLIMKSKGLPYLETHAE 570
           R TVSL VI+ ELT  L  +  +M   + SK VAD F    IY+  +   G P+L+   E
Sbjct: 530 RMTVSLVVIMFELTGGLEYIVPLMAAAVTSKWVADAFGKEGIYEAHIHLNGYPFLDVKDE 589

Query: 571 PYMRQLTVGDVV-----TGPLQIF-HGYEKVRNVVFVLKTTSHNGFPVIDEPPFSEAPVL 624
              R L   DV+       PL +       V +V  ++K T +NGFPV+      ++  L
Sbjct: 590 FTHRTLAT-DVMRPRRGEPPLSVLTQDSMTVEDVETLIKETDYNGFPVVVS---RDSERL 645

Query: 625 FGIILRHHLLTLLRKKVFMSAPMAMGGDVLRQFSADDFAKRGSDRGERIEDIHLTQEEMD 684
            G   R  L+  ++     +A     G V                      ++ T+E  +
Sbjct: 646 IGFAQRRELILAIK-----NARQRQEGIVSNSI------------------MYFTEEPPE 682

Query: 685 M------FIDLHPFTNASPYTVVESMSLGKALILFRELGLRHLLVIPKIPSRSPVVGILT 738
           +       + L    N SP+TV +   +   + +FR+LGLR  LV         ++GI+T
Sbjct: 683 LPANSPHPLKLRRILNLSPFTVTDHTPMETVVDIFRKLGLRQCLV----TRSGRLLGIIT 738

Query: 739 RHD 741
           + D
Sbjct: 739 KKD 741


>CLC5_RAT (P51796) Chloride channel protein 5 (ClC-5)
          Length = 746

 Score =  191 bits (486), Expect = 5e-48
 Identities = 179/661 (27%), Positives = 297/661 (44%), Gaps = 112/661 (16%)

Query: 122 VTFFASNLALTLFATIITAMI---APAAAGSGISEVKAYLNGVDAPGIFTLPTLIVKIIG 178
           V +F   L   LFA +  +++   AP A GSGI E+K  L+G    G     TL++K I 
Sbjct: 138 VNYFMYVLWALLFAFLAVSLVKAFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIKTIT 197

Query: 179 SITAVSSSLHIGKAGPMLHTGACVAALLGQGGSKRYGLTWKWLRYFKNDRDRRDLIVCGS 238
            + AVSS L +GK GP++H   C   +L    +K          Y KN+  RR+++   +
Sbjct: 198 LVLAVSSGLSLGKEGPLVHVACCCGNILCHCFNK----------YRKNEAKRREVLSAAA 247

Query: 239 AAGIAAAFRAPVGGVLFALEEMASWWRTALLWRAFFTTAIVAIFLRAMIDVCLSGKCGLF 298
           AAG++ AF AP+GGVLF+LEE++ ++    LWR+FF   + A  LR++           F
Sbjct: 248 AAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSI---------NPF 298

Query: 299 GKGGLIMFDAYSGSLMYHAKDVPLVFILGVIGGILGSLY---NYLWNKVLRIYNAINEKG 355
           G   L++F     +  +  + VP + +LG+ GG+ G+L+   N  W +  +       K 
Sbjct: 299 GNSRLVLFYVEFHTPWHLFELVPFI-VLGIFGGLWGALFIRTNIAWCRKRKTTQL--GKY 355

Query: 356 TICKILLACVISMFTSCLLFGLPWL-ASCQPCPADPVEPCPTIGRSGIYKKFQCPPGHYN 414
            + ++L   +++  T+ L F   +   S     ++    C  +  S +     C   ++ 
Sbjct: 356 PVVEVL---IVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKL-----CDYENH- 406

Query: 415 DLASLIFNTNDDAIRNLFSKNTDSEFQYSSMF---IFFITGFFLSILSCGVVVPAGVFVP 471
                 FNT+                 YS+M+   +  I    ++I + G+ +P+G+F+P
Sbjct: 407 ------FNTSKG---GELPDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIP 457

Query: 472 IIVTGASYGRFVGMLFGKKSNLNH------------------GLYAVLGAASFLGGSMRT 513
            +  GA  GR +G+   + +  +H                  GLYA++GAA+ LGG  R 
Sbjct: 458 SMAVGAIAGRLLGVGMEQLAYYHHDWGIFNSWCSQGADCITPGLYAMVGAAACLGGVTRM 517

Query: 514 TVSLCVIILELTNNLLLLPLIMMVLLVSKSVADVF-NANIYDLIMKSKGLPYLETHAEPY 572
           TVSL VI+ ELT  L  +  +M   + SK VAD      IYD  ++  G P+LE   E +
Sbjct: 518 TVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEA-KEEF 576

Query: 573 MRQLTVGDVV----TGPL--QIFHGYEKVRNVVFVLKTTSHNGFPVIDEPPFSEAPVLFG 626
             +    DV+      PL   +      V +V  ++  T+++GFPV+      E+  L G
Sbjct: 577 AHKTLAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVS---RESQRLVG 633

Query: 627 IILRHHLLTLLRKKVFMSAPMAMGGDVLRQFSADDFAKRGSDRGERIEDIHLTQEEMDM- 685
            +LR  L+  +                         A++  D       I+ T+    M 
Sbjct: 634 FVLRRDLIISIEN-----------------------ARKKQDGVVSTSIIYFTEHSPPMP 670

Query: 686 -----FIDLHPFTNASPYTVVESMSLGKALILFRELGLRHLLVIPKIPSRSPVVGILTRH 740
                 + L    + SP+TV +   +   + +FR+LGLR  LV         ++GI+T+ 
Sbjct: 671 PYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLV----THNGRLLGIITKK 726

Query: 741 D 741
           D
Sbjct: 727 D 727


>CLC5_MOUSE (Q9WVD4) Chloride channel protein 5 (ClC-5)
          Length = 746

 Score =  191 bits (485), Expect = 6e-48
 Identities = 179/661 (27%), Positives = 297/661 (44%), Gaps = 112/661 (16%)

Query: 122 VTFFASNLALTLFATIITAMI---APAAAGSGISEVKAYLNGVDAPGIFTLPTLIVKIIG 178
           V +F   L   LFA +  +++   AP A GSGI E+K  L+G    G     TL++K I 
Sbjct: 138 VNYFMYVLWALLFAFLAVSLVKAFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIKTIT 197

Query: 179 SITAVSSSLHIGKAGPMLHTGACVAALLGQGGSKRYGLTWKWLRYFKNDRDRRDLIVCGS 238
            + AVSS L +GK GP++H   C   +L    +K          Y KN+  RR+++   +
Sbjct: 198 LVLAVSSGLSLGKEGPLVHVACCCGNILCHCFNK----------YRKNEAKRREVLSAAA 247

Query: 239 AAGIAAAFRAPVGGVLFALEEMASWWRTALLWRAFFTTAIVAIFLRAMIDVCLSGKCGLF 298
           AAG++ AF AP+GGVLF+LEE++ ++    LWR+FF   + A  LR++           F
Sbjct: 248 AAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSI---------NPF 298

Query: 299 GKGGLIMFDAYSGSLMYHAKDVPLVFILGVIGGILGSLY---NYLWNKVLRIYNAINEKG 355
           G   L++F     +  +  + VP + +LG+ GG+ G+L+   N  W +  +       K 
Sbjct: 299 GNSRLVLFYVEFHTPWHLFELVPFI-VLGIFGGLWGALFIRTNIAWCRKRKTTQL--GKY 355

Query: 356 TICKILLACVISMFTSCLLFGLPWL-ASCQPCPADPVEPCPTIGRSGIYKKFQCPPGHYN 414
            + ++L   +++  T+ L F   +   S     ++    C  +  S +     C   ++ 
Sbjct: 356 PVVEVL---IVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKL-----CDYENH- 406

Query: 415 DLASLIFNTNDDAIRNLFSKNTDSEFQYSSMF---IFFITGFFLSILSCGVVVPAGVFVP 471
                 FNT+                 YS+M+   +  I    ++I + G+ +P+G+F+P
Sbjct: 407 ------FNTSKG---GELPDRPAGVGIYSAMWQLALTLILKIVITIFTFGMKIPSGLFIP 457

Query: 472 IIVTGASYGRFVGMLFGKKSNLNH------------------GLYAVLGAASFLGGSMRT 513
            +  GA  GR +G+   + +  +H                  GLYA++GAA+ LGG  R 
Sbjct: 458 SMAVGAIAGRLLGVGMEQLAYYHHDWGIFNSWCSQGADCITPGLYAMVGAAACLGGVTRM 517

Query: 514 TVSLCVIILELTNNLLLLPLIMMVLLVSKSVADVF-NANIYDLIMKSKGLPYLETHAEPY 572
           TVSL VI+ ELT  L  +  +M   + SK VAD      IYD  ++  G P+LE   E +
Sbjct: 518 TVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEA-KEEF 576

Query: 573 MRQLTVGDVV----TGPL--QIFHGYEKVRNVVFVLKTTSHNGFPVIDEPPFSEAPVLFG 626
             +    DV+      PL   +      V +V  ++  T+++GFPV+      E+  L G
Sbjct: 577 AHKTLAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVS---RESQRLVG 633

Query: 627 IILRHHLLTLLRKKVFMSAPMAMGGDVLRQFSADDFAKRGSDRGERIEDIHLTQEEMDM- 685
            +LR  L+  +                         A++  D       I+ T+    M 
Sbjct: 634 FVLRRDLIISIEN-----------------------ARKKQDGVVSTSIIYFTEHSPPMP 670

Query: 686 -----FIDLHPFTNASPYTVVESMSLGKALILFRELGLRHLLVIPKIPSRSPVVGILTRH 740
                 + L    + SP+TV +   +   + +FR+LGLR  LV         ++GI+T+ 
Sbjct: 671 PYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLV----THNGRLLGIITKK 726

Query: 741 D 741
           D
Sbjct: 727 D 727


>CLC5_HUMAN (P51795) Chloride channel protein 5 (ClC-5)
          Length = 746

 Score =  187 bits (476), Expect = 7e-47
 Identities = 181/668 (27%), Positives = 300/668 (44%), Gaps = 126/668 (18%)

Query: 122 VTFFASNLALTLFATIITAMI---APAAAGSGISEVKAYLNGVDAPGIFTLPTLIVKIIG 178
           V +F   L   LFA +  +++   AP A GSGI E+K  L+G    G     TL++K I 
Sbjct: 138 VNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIKTIT 197

Query: 179 SITAVSSSLHIGKAGPMLHTGACVAALLGQGGSKRYGLTWKWLRYFKNDRDRRDLIVCGS 238
            + AVSS L +GK GP++H   C   +L    +K          Y KN+  RR+++   +
Sbjct: 198 LVLAVSSGLSLGKEGPLVHVACCCGNILCHCFNK----------YRKNEAKRREVLSAAA 247

Query: 239 AAGIAAAFRAPVGGVLFALEEMASWWRTALLWRAFFTTAIVAIFLRAMIDVCLSGKCGLF 298
           AAG++ AF AP+GGVLF+LEE++ ++    LWR+FF   + A  LR++           F
Sbjct: 248 AAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSI---------NPF 298

Query: 299 GKGGLIMFDAYSGSLMYHAKDVPLVFILGVIGGILGSLY---NYLWNKVLRIYNAINEKG 355
           G   L++F     +  +  + VP + +LG+ GG+ G+L+   N  W +  +       K 
Sbjct: 299 GNSRLVLFYVEFHTPWHLFELVPFI-LLGIFGGLWGALFIRTNIAWCRKRKTTQL--GKY 355

Query: 356 TICKILLACVISMFTSCLLFGLPWLASCQPCPADPVEPCPTIGRSGIYKKFQCPPGHYND 415
            + ++L   V++  T+ L F              P E    +  S +  +       +ND
Sbjct: 356 PVIEVL---VVTAITAILAF--------------PNE-YTRMSTSELISEL------FND 391

Query: 416 LASLIFNTNDDAIRNLFSKNTDSEFQ--------YSSMF---IFFITGFFLSILSCGVVV 464
              L+ ++      N F+ +   E          YS+M+   +  I    ++I + G+ +
Sbjct: 392 -CGLLDSSKLCDYENRFNTSKGGELPDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKI 450

Query: 465 PAGVFVPIIVTGASYGRFVGM-------------LFGKKSN-----LNHGLYAVLGAASF 506
           P+G+F+P +  GA  GR +G+             +F    +     +  GLYA++GAA+ 
Sbjct: 451 PSGLFIPSMAVGAIAGRLLGVGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAAC 510

Query: 507 LGGSMRTTVSLCVIILELTNNLLLLPLIMMVLLVSKSVADVF-NANIYDLIMKSKGLPYL 565
           LGG  R TVSL VI+ ELT  L  +  +M   + SK VAD      IYD  ++  G P+L
Sbjct: 511 LGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFL 570

Query: 566 ETHAEPYMRQLTVGDVV----TGPL--QIFHGYEKVRNVVFVLKTTSHNGFPVIDEPPFS 619
           E   E +  +    DV+      PL   +      V +V  ++  T+++GFPV+      
Sbjct: 571 EA-KEEFAHKTLAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVS---R 626

Query: 620 EAPVLFGIILRHHLLTLLRKKVFMSAPMAMGGDVLRQFSADDFAKRGSDRGERIEDIHLT 679
           E+  L G +LR  L+  +                         A++  D       I+ T
Sbjct: 627 ESQRLVGFVLRRDLIISIEN-----------------------ARKKQDGVVSTSIIYFT 663

Query: 680 QEEMDM------FIDLHPFTNASPYTVVESMSLGKALILFRELGLRHLLVIPKIPSRSPV 733
           +    +       + L    + SP+TV +   +   + +FR+LGLR  LV         +
Sbjct: 664 EHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLV----THNGRL 719

Query: 734 VGILTRHD 741
           +GI+T+ D
Sbjct: 720 LGIITKKD 727


  Database: sprot
    Posted date:  Nov 25, 2004 10:54 AM
  Number of letters in database: 59,974,054
  Number of sequences in database:  164,201
  
Lambda     K      H
   0.327    0.142    0.437 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 92,207,670
Number of Sequences: 164201
Number of extensions: 4046209
Number of successful extensions: 12299
Number of sequences better than 10.0: 73
Number of HSP's better than 10.0 without gapping: 63
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 11854
Number of HSP's gapped (non-prelim): 202
length of query: 780
length of database: 59,974,054
effective HSP length: 118
effective length of query: 662
effective length of database: 40,598,336
effective search space: 26876098432
effective search space used: 26876098432
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 70 (31.6 bits)