BLASTP 2.2.2 [Dec-14-2001]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= TM0029a.6
         (183 letters)

Database: sprot 
           164,201 sequences; 59,974,054 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

CCR4_YEAST (P31384) Glucose-repressible alcohol dehydrogenase tr...    68  1e-11
CC4L_MOUSE (Q8K3P5) Carbon catabolite repressor protein 4 homolo...    62  6e-10
CC4L_HUMAN (Q9ULM6) Carbon catabolite repressor protein 4 homolo...    62  7e-10
NOCT_XENLA (P79942) Nocturnin (Rhythmic message 1) (RM1)               54  2e-07
NOCT_MOUSE (O35710) Nocturnin (CCR4 protein homolog)                   53  5e-07
NOCT_HUMAN (Q9UK39) Nocturnin (CCR4 protein homolog)                   53  5e-07
K759_HUMAN (Q9UNK9) Protein KIAA0759                                   41  0.001
ANGE_DROME (Q24239) Angel protein (Angel 39) (ANG39)                   38  0.015
NOCT_RAT (Q9ET55) Nocturnin (CCR4 protein homolog) (Fragment)          37  0.020
YML8_YEAST (Q03210) Hypothetical 57.7 kDa protein in NDI1-ATR1 i...    35  0.13
ISC1_YEAST (P40015) Inositol phosphosphingolipids phospholipase ...    31  1.4
YB14_METMA (Q8PXV2) Hypothetical UPF0264 protein MM1114                30  3.1
Y8D6_METAC (Q8THS6) Hypothetical UPF0264 protein MA4436                30  3.1
LIPM_NEIMA (P57037) Capsule polysaccharide modification protein ...    29  7.0
PLO1_HUMAN (Q02809) Procollagen-lysine,2-oxoglutarate 5-dioxygen...    28  9.1
MEND_BACSU (P23970) Menaquinone biosynthesis protein menD [Inclu...    28  9.1
LIPM_NEIMB (Q05013) Capsule polysaccharide modification protein ...    28  9.1

>CCR4_YEAST (P31384) Glucose-repressible alcohol dehydrogenase
           transcriptional effector (EC 3.1.-.-) (Cytoplasmic
           deadenylase) (Carbon catabolite repressor protein 4)
          Length = 837

 Score = 68.2 bits (165), Expect = 1e-11
 Identities = 56/190 (29%), Positives = 77/190 (40%), Gaps = 31/190 (16%)

Query: 3   THVNVHQDLKDVKLWQVHTLLKGLEKIAASAD----------IPMLVCGDFNSNPGSAPH 52
           TH++      DVK +QV  LL  LE +                P+L+CGDFNS   SA +
Sbjct: 664 THLHWDPKFNDVKTFQVGVLLDHLETLLKEETSHNFRQDIKKFPVLICGDFNSYINSAVY 723

Query: 53  ALLAMGKVDPSHPDLAIDPLSILRPHSKLVHQLPLVSAYSSFARTIGLGYEQHKRRLDSA 112
            L+  G+V         D            H L L S+Y+                    
Sbjct: 724 ELINTGRVQIHQEGNGRD--FGYMSEKNFSHNLALKSSYNCIG----------------- 764

Query: 113 TNEPLFTNVTRDFIGALDYIFYTADSLVVESLLELLDEESLRKDTALPSPEWSSDHIALL 172
             E  FTN T  F   +DYI+++  +L V  LL  +D E   K    P+ ++ SDHI LL
Sbjct: 765 --ELPFTNFTPSFTDVIDYIWFSTHALRVRGLLGEVDPEYESKFIGFPNDKFPSDHIPLL 822

Query: 173 AEFRCCKNRS 182
           A F   K  +
Sbjct: 823 ARFEFMKTNT 832


>CC4L_MOUSE (Q8K3P5) Carbon catabolite repressor protein 4 homolog
           (EC 3.1.-.-) (Cytoplasmic deadenylase) (CCR4 carbon
           catabolite repression 4-like) (Nocturnin homolog)
          Length = 557

 Score = 62.4 bits (150), Expect = 6e-10
 Identities = 55/191 (28%), Positives = 82/191 (42%), Gaps = 28/191 (14%)

Query: 1   ANTHVNVHQDLKDVKLWQVHTLLKGLEKIAASAD-------------IPMLVCGDFNSNP 47
           AN H++   +  DVKL Q    L  ++ I   A              IP+++C D NS P
Sbjct: 358 ANAHMHWDPEYSDVKLVQTMMFLSEVKNIIDKASRSLKSSVLGECGTIPLVLCADLNSLP 417

Query: 48  GSAPHALLAMGKVDPSHPDLAIDPLSILRPHSKLVHQLPLVSAYSSFARTIGLGYEQHKR 107
            S     L+ G V+ +H D             +L +   L +   +    +  G   H  
Sbjct: 418 DSGVVEYLSTGGVETNHKDF-----------KELRYNESLTNFSCNGKNGMTNGRITHGF 466

Query: 108 RLDSATNEPL--FTNVTRDFIGALDYIFYTADSLVVESLLELLDEESLRKD--TALPSPE 163
           +L SA    L  +TN T DF G +DYIFY+   L   ++L  LD   L ++  +  P P 
Sbjct: 467 KLKSAYENGLMPYTNYTFDFKGIIDYIFYSKPQLNTLAILGPLDHHWLVENNISGCPHPL 526

Query: 164 WSSDHIALLAE 174
             SDH +L A+
Sbjct: 527 IPSDHFSLFAQ 537


>CC4L_HUMAN (Q9ULM6) Carbon catabolite repressor protein 4 homolog
           (EC 3.1.-.-) (Cytoplasmic deadenylase) (CCR4 carbon
           catabolite repression 4-like) (Nocturnin homolog)
          Length = 557

 Score = 62.0 bits (149), Expect = 7e-10
 Identities = 58/191 (30%), Positives = 82/191 (42%), Gaps = 28/191 (14%)

Query: 1   ANTHVNVHQDLKDVKLWQVHTLLKGLEKIAASAD-------------IPMLVCGDFNSNP 47
           AN H++   +  DVKL Q    L  ++ I   A              IP+++C D NS P
Sbjct: 358 ANAHMHWDPEYSDVKLVQTMMFLSEVKNIIDKASRNLKSSVLGEFGTIPLVLCADLNSLP 417

Query: 48  GSAPHALLAMGKVDPSHPDLAIDPLSILRPHSKLVHQLPLVSAYSSFARTIGLGYEQHKR 107
            S     L+ G V+ +H D        LR +  L +     S +     T G     H  
Sbjct: 418 DSGVVEYLSTGGVETNHKDF-----KELRYNESLTN----FSCHGKNGTTNGR--ITHGF 466

Query: 108 RLDSATNEPL--FTNVTRDFIGALDYIFYTADSLVVESLLELLDEESLRKD--TALPSPE 163
           +L SA    L  +TN T DF G +DYIFY+   L    +L  LD   L ++  +  P P 
Sbjct: 467 KLQSAYESGLMPYTNYTFDFKGIIDYIFYSKPQLNTLGILGPLDHHWLVENNISGCPHPL 526

Query: 164 WSSDHIALLAE 174
             SDH +L A+
Sbjct: 527 IPSDHFSLFAQ 537


>NOCT_XENLA (P79942) Nocturnin (Rhythmic message 1) (RM1)
          Length = 388

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 48/179 (26%), Positives = 73/179 (39%), Gaps = 44/179 (24%)

Query: 1   ANTHVNVHQDLKDVKLWQVHTLLKGLEKIAASADIPMLVCGDFNSNPGSAPHALLAMGKV 60
           A TH+      +  +L Q   LL  LE I   A +P+++CGDFN++P    +   A    
Sbjct: 240 AVTHLKARTGWERFRLAQGSDLLDNLESITQGATVPLIICGDFNADPTEEVYKRFASS-- 297

Query: 61  DPSHPDLAIDPLSILRPHSKLVHQLPLVSAYSSFARTIGLGYEQHKRRLDSATNEPLFT- 119
                                   L L SAY              K   +   +EP +T 
Sbjct: 298 -----------------------SLNLNSAY--------------KLLSEDGESEPPYTT 320

Query: 120 ---NVTRDFIGALDYIFYTADSLVVESLLELLDEESLRKDTALPSPEWSSDHIALLAEF 175
                T +    LDYI+Y+  +L V + L L  EE +  +  LPS  + SDH++L+ +F
Sbjct: 321 WKIRTTGESCHTLDYIWYSQHALRVNAALGLPTEEQIGPN-RLPSFNYPSDHLSLVCDF 378


>NOCT_MOUSE (O35710) Nocturnin (CCR4 protein homolog)
          Length = 429

 Score = 52.8 bits (125), Expect = 5e-07
 Identities = 47/179 (26%), Positives = 74/179 (41%), Gaps = 44/179 (24%)

Query: 1   ANTHVNVHQDLKDVKLWQVHTLLKGLEKIAASADIPMLVCGDFNSNPGSAPHALLAMGKV 60
           A TH+      +  +  Q   LL+ L+ I   A IP++VCGDFN+ P    +   A   +
Sbjct: 281 AVTHLKARTGWERFRSAQGCDLLQNLQNITQGAKIPLIVCGDFNAEPTEEVYKHFASSSL 340

Query: 61  DPSHPDLAIDPLSILRPHSKLVHQLPLVSAYSSFARTIGLGYEQHKRRLDSATNEPLFTN 120
           +                         L SAY   +                  +EP +T 
Sbjct: 341 N-------------------------LNSAYKLLS--------------PDGQSEPPYTT 361

Query: 121 ----VTRDFIGALDYIFYTADSLVVESLLELLDEESLRKDTALPSPEWSSDHIALLAEF 175
                + +    LDYI+Y+  +L V S L+LL EE +  +  LPS  + SDH++L+ +F
Sbjct: 362 WKIRTSGECRHTLDYIWYSRHALSVTSALDLLTEEQIGPN-RLPSFHYPSDHLSLVCDF 419


>NOCT_HUMAN (Q9UK39) Nocturnin (CCR4 protein homolog)
          Length = 431

 Score = 52.8 bits (125), Expect = 5e-07
 Identities = 47/179 (26%), Positives = 74/179 (41%), Gaps = 44/179 (24%)

Query: 1   ANTHVNVHQDLKDVKLWQVHTLLKGLEKIAASADIPMLVCGDFNSNPGSAPHALLAMGKV 60
           A TH+      +  +  Q   LL+ L+ I   A IP++VCGDFN+ P    +   A   +
Sbjct: 283 AVTHLKARTGWERFRSAQGCDLLQNLQNITQGAKIPLIVCGDFNAEPTEEVYKHFASSNL 342

Query: 61  DPSHPDLAIDPLSILRPHSKLVHQLPLVSAYSSFARTIGLGYEQHKRRLDSATNEPLFTN 120
           +                         L SAY   +                  +EP +T 
Sbjct: 343 N-------------------------LNSAYKLLSA--------------DGQSEPPYTT 363

Query: 121 ----VTRDFIGALDYIFYTADSLVVESLLELLDEESLRKDTALPSPEWSSDHIALLAEF 175
                + +    LDYI+Y+  +L V S L+LL EE +  +  LPS  + SDH++L+ +F
Sbjct: 364 WKIRTSGECRHTLDYIWYSKHALNVRSALDLLTEEQIGPN-RLPSFNYPSDHLSLVCDF 421


>K759_HUMAN (Q9UNK9) Protein KIAA0759
          Length = 670

 Score = 41.2 bits (95), Expect = 0.001
 Identities = 23/63 (36%), Positives = 37/63 (58%), Gaps = 3/63 (4%)

Query: 1   ANTHVNVHQDLKDVKLWQVHTLLKGLEKIAASAD---IPMLVCGDFNSNPGSAPHALLAM 57
           ANTH+  +    DVKL Q+  LL  ++K+A  +D    P+++CGD NS P S  +  +  
Sbjct: 389 ANTHILYNPRRGDVKLAQMAILLAEVDKVARLSDGSHCPIILCGDLNSVPDSPLYNFIRD 448

Query: 58  GKV 60
           G++
Sbjct: 449 GEL 451



 Score = 39.3 bits (90), Expect = 0.005
 Identities = 33/103 (32%), Positives = 42/103 (40%), Gaps = 19/103 (18%)

Query: 83  HQLPLVSAYSSFARTIGLGYEQHKRRLDSATNEPLFTNVTRDFI----------GALDYI 132
           H L L S Y+ F           +R     T  PL   +T D+I             D+ 
Sbjct: 570 HCLHLTSVYTHFLP---------QRGRPEVTTMPLGLGMTVDYIFFSAESCENGNRTDHR 620

Query: 133 FYTADSLVVESLLELLDEESLRKDTALPSPEWSSDHIALLAEF 175
            Y   +L +   L LL EE L     LP+P  SSDH+ LLA F
Sbjct: 621 LYRDGTLKLLGRLSLLSEEILWAANGLPNPFCSSDHLCLLASF 663


>ANGE_DROME (Q24239) Angel protein (Angel 39) (ANG39)
          Length = 354

 Score = 37.7 bits (86), Expect = 0.015
 Identities = 20/51 (39%), Positives = 30/51 (58%), Gaps = 2/51 (3%)

Query: 1   ANTHVNVHQDLKDVKLWQVHTLLKGLEKIAASADIPMLVCGDFNSNPGSAP 51
           A TH+  +    DV+  QV  +L+ L+    S D P+++ GDFNS P S+P
Sbjct: 210 ATTHLLFNTKRSDVRCAQVERILEELQSF--STDTPIVLTGDFNSLPDSSP 258


>NOCT_RAT (Q9ET55) Nocturnin (CCR4 protein homolog) (Fragment)
          Length = 253

 Score = 37.4 bits (85), Expect = 0.020
 Identities = 18/47 (38%), Positives = 26/47 (55%)

Query: 1   ANTHVNVHQDLKDVKLWQVHTLLKGLEKIAASADIPMLVCGDFNSNP 47
           A TH+      +  +  Q   LL+ L+ I   A IP++VCGDFN+ P
Sbjct: 207 AVTHLKARTGWERFRSAQGCDLLQSLQNITEGAKIPLIVCGDFNAEP 253


>YML8_YEAST (Q03210) Hypothetical 57.7 kDa protein in NDI1-ATR1
           intergenic region
          Length = 505

 Score = 34.7 bits (78), Expect = 0.13
 Identities = 50/244 (20%), Positives = 89/244 (35%), Gaps = 68/244 (27%)

Query: 1   ANTHVNVHQDLKDVKLWQVHTLLKGLEKIAASADIP---MLVCGDFNSNPGSAPHALLAM 57
           ANTH+  H      +L Q + +L+ +++I A +       L+ GDFN+ P   P+  +  
Sbjct: 250 ANTHLFWHPFGVFERLRQSYLVLQKIQEIKACSKYNGWHSLLMGDFNTEPEEPPYLAITK 309

Query: 58  GKVDPSHPDLAIDPLSILRPHSK------------------------------------- 80
             +    P  A+   S+   +SK                                     
Sbjct: 310 RPLILKGPIRAMVECSLAYRYSKKRNGEESDQDDEECDEKSRGEGHSDQPQNPKPESFTA 369

Query: 81  ------LVHQLPLV--SAYSSFARTIGLGYEQ-HKRRLDSATNEPLFTNVTRDFIGALDY 131
                 LV+QL  +  S +       G+GY + H    + +  EP  +N    + G LDY
Sbjct: 370 TKEEKALVNQLVALHNSLHVKGVSLYGIGYGKVHPENANGSHGEPGLSNWANTWCGLLDY 429

Query: 132 IFYTA-------------------DSLVVESLLELLDEESLRKDTALPSPEWSSDHIALL 172
           IFY                     +++ +   L +   + + K +     E++SDHI+L+
Sbjct: 430 IFYIEGDHNQDTRQKEPLNAFEGNNNVKIIGYLRMPCAQEMPKHSQPFEGEYASDHISLM 489

Query: 173 AEFR 176
            + R
Sbjct: 490 CQIR 493


>ISC1_YEAST (P40015) Inositol phosphosphingolipids phospholipase C
           (EC 3.1.4.-) (IPS phospholipase C) (IPS-PLC) (Neutral
           sphingomyelinase) (N-SMase) (nSMase)
          Length = 477

 Score = 31.2 bits (69), Expect = 1.4
 Identities = 17/38 (44%), Positives = 20/38 (51%), Gaps = 2/38 (5%)

Query: 26  LEKIAASADIPMLVCGDFNSNPGSAPHALLAM--GKVD 61
           L K+   A   ++V GD NS PGS PH  L    G VD
Sbjct: 215 LIKLYRQAGYAVIVVGDLNSRPGSLPHKFLTQEAGLVD 252


>YB14_METMA (Q8PXV2) Hypothetical UPF0264 protein MM1114
          Length = 234

 Score = 30.0 bits (66), Expect = 3.1
 Identities = 32/143 (22%), Positives = 61/143 (42%), Gaps = 12/143 (8%)

Query: 18  QVHTLLKGLEKIAASADIPMLVCGDFNSNPGSAPHALLAMGKVDPSHPDLAIDPLSILRP 77
           +V  ++ G + I+A+        GDFN  PG+A  A L        +  + +  +     
Sbjct: 44  EVKAVVNGRQPISATI-------GDFNYKPGTAALAALGAAVAGADYIKVGLYDIQTESQ 96

Query: 78  HSKLVHQLP-LVSAYSSFARTIGLGYEQHKRRLDSATNEPLFTNVTRDFIGALDYIFYTA 136
             +L+ ++   V  Y+   + +  GY  +K R++S +  PL         G +D +    
Sbjct: 97  ALELLTKITRAVKDYNPLKKVVASGYSDYK-RINSIS--PLLLPAVAAEAG-VDVVMVDT 152

Query: 137 DSLVVESLLELLDEESLRKDTAL 159
                +S  E +DE+ L++ T L
Sbjct: 153 GVKDGKSTFEFMDEKELKEFTDL 175


>Y8D6_METAC (Q8THS6) Hypothetical UPF0264 protein MA4436
          Length = 234

 Score = 30.0 bits (66), Expect = 3.1
 Identities = 29/120 (24%), Positives = 51/120 (42%), Gaps = 5/120 (4%)

Query: 41  GDFNSNPGSAPHALLAMGKVDPSHPDLAIDPLSILRPHSKLVHQLPL-VSAYSSFARTIG 99
           GDFN  PG+A  A L        +  + +  +       +L+ ++ L V  Y    + + 
Sbjct: 60  GDFNYKPGTASLAALGAAVAGADYIKVGLYDIQTEAQALELLTKITLAVKDYDPSKKVVA 119

Query: 100 LGYEQHKRRLDSATNEPLFTNVTRDFIGALDYIFYTADSLVVESLLELLDEESLRKDTAL 159
            GY  +K R++S +  PL         G +D +         +S  E +DE+ L++ T L
Sbjct: 120 SGYSDYK-RINSIS--PLLLPAVAAEAG-VDVVMVDTGIKDGKSTFEFMDEQELKEFTDL 175


>LIPM_NEIMA (P57037) Capsule polysaccharide modification protein
           lipA
          Length = 704

 Score = 28.9 bits (63), Expect = 7.0
 Identities = 23/92 (25%), Positives = 42/92 (45%), Gaps = 10/92 (10%)

Query: 83  HQLPLVSAYSSFARTIGLGYEQHKRRLDSATNEPLFTNVTRDFIGALDYIFYTADSLVVE 142
           HQLP ++    F R++GLG   +        +  ++ + TR     L+ +   AD++  E
Sbjct: 75  HQLPFIALEDGFLRSLGLGVSGYPPYSIVYDDIGIYYDTTRP--SRLEQLILAADTMPSE 132

Query: 143 SL------LELLDEESLRKDTALPSPEWSSDH 168
           +L      ++ + +  L K     +PE S DH
Sbjct: 133 TLAQARQAMDFILQHHLSKYN--HAPELSDDH 162


>PLO1_HUMAN (Q02809) Procollagen-lysine,2-oxoglutarate 5-dioxygenase
           1 precursor (EC 1.14.11.4) (Lysyl hydroxylase 1) (LH1)
          Length = 727

 Score = 28.5 bits (62), Expect = 9.1
 Identities = 28/115 (24%), Positives = 49/115 (42%), Gaps = 10/115 (8%)

Query: 18  QVHTLLKGLEKIAASADIPMLVCGDFNSNPGSAPHALLAMGKVDPSHPDLAIDPLSILRP 77
           +V  L K LEK A   D+ +L    ++    S P  LL   K   +   +      ++ P
Sbjct: 77  KVRLLKKALEKHADKEDLVILFTDSYDVLFASGPRELLK--KFRQARSQVVFSAEELIYP 134

Query: 78  HSKLVHQLPLVSAYSSFARTIG-LGYEQHKRRL-------DSATNEPLFTNVTRD 124
             +L  + P+VS    F  + G +GY  +  +L       DS +++  +T +  D
Sbjct: 135 DRRLETKYPVVSDGKRFLGSGGFIGYAPNLSKLVAEWEGQDSDSDQLFYTKIFLD 189


>MEND_BACSU (P23970) Menaquinone biosynthesis protein menD
           [Includes:
           2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate
           synthase (EC 2.5.1.64) (SHCHC synthase); 2-oxoglutarate
           decarboxylase (EC 4.1.1.71) (Alpha-ketoglutarate
           decarboxylase) (KDC)]
          Length = 580

 Score = 28.5 bits (62), Expect = 9.1
 Identities = 23/74 (31%), Positives = 42/74 (56%), Gaps = 6/74 (8%)

Query: 23  LKGLEKIAASADIPMLVCGDFNSNPGSAPHALLAMGKVDPSHPDLAIDPLSILRPHSKLV 82
           L  + ++ A A+  M+VCG+ +S+  +    ++A+ K    +P LA DPLS LR  + + 
Sbjct: 209 LSDVAEMLAEAEKGMIVCGELHSD--ADKENIIALSKA-LQYPILA-DPLSNLR--NGVH 262

Query: 83  HQLPLVSAYSSFAR 96
            +  ++ AY SF +
Sbjct: 263 DKSTVIDAYDSFLK 276


>LIPM_NEIMB (Q05013) Capsule polysaccharide modification protein
           lipA
          Length = 704

 Score = 28.5 bits (62), Expect = 9.1
 Identities = 23/92 (25%), Positives = 42/92 (45%), Gaps = 10/92 (10%)

Query: 83  HQLPLVSAYSSFARTIGLGYEQHKRRLDSATNEPLFTNVTRDFIGALDYIFYTADSLVVE 142
           HQLP ++    F R++GLG   +        +  ++ + TR     L+ +   AD++  E
Sbjct: 75  HQLPFIALEDGFLRSLGLGVAGYPPYSIVYDDIGIYYDTTRP--SRLEQLILAADTMPSE 132

Query: 143 SL------LELLDEESLRKDTALPSPEWSSDH 168
           +L      ++ + +  L K     +PE S DH
Sbjct: 133 TLAQAQQAMDFILQHHLSKYN--HAPELSDDH 162


  Database: sprot
    Posted date:  Nov 25, 2004 10:54 AM
  Number of letters in database: 59,974,054
  Number of sequences in database:  164,201
  
Lambda     K      H
   0.319    0.135    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,669,719
Number of Sequences: 164201
Number of extensions: 843020
Number of successful extensions: 1983
Number of sequences better than 10.0: 17
Number of HSP's better than 10.0 without gapping: 9
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 1955
Number of HSP's gapped (non-prelim): 24
length of query: 183
length of database: 59,974,054
effective HSP length: 103
effective length of query: 80
effective length of database: 43,061,351
effective search space: 3444908080
effective search space used: 3444908080
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)