BLASTP 2.2.2 [Dec-14-2001]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= TM0028b.3
         (288 letters)

Database: sprot 
           164,201 sequences; 59,974,054 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

ODPA_PEA (P52902) Pyruvate dehydrogenase E1 component alpha subu...   492  e-139
ODPA_ARATH (P52901) Pyruvate dehydrogenase E1 component alpha su...   477  e-134
ODPA_SOLTU (P52903) Pyruvate dehydrogenase E1 component alpha su...   462  e-130
ODPA_SCHPO (Q10489) Pyruvate dehydrogenase E1 component alpha su...   281  1e-75
ODPA_HUMAN (P08559) Pyruvate dehydrogenase E1 component alpha su...   277  2e-74
ODPA_YEAST (P16387) Pyruvate dehydrogenase E1 component alpha su...   276  3e-74
ODPA_SMIMA (P52900) Pyruvate dehydrogenase E1 component alpha su...   276  3e-74
ODPA_RAT (P26284) Pyruvate dehydrogenase E1 component alpha subu...   276  5e-74
ODPA_PIG (P29804) Pyruvate dehydrogenase E1 component alpha subu...   276  5e-74
ODPA_MOUSE (P35486) Pyruvate dehydrogenase E1 component alpha su...   274  2e-73
ODPT_HUMAN (P29803) Pyruvate dehydrogenase E1 component alpha su...   272  8e-73
ODPA_KLULA (O13366) Pyruvate dehydrogenase E1 component alpha su...   271  1e-72
ODPA_CAEEL (P52899) Probable pyruvate dehydrogenase E1 component...   271  1e-72
ODPT_MOUSE (P35487) Pyruvate dehydrogenase E1 component alpha su...   269  7e-72
ODPT_RAT (Q06437) Pyruvate dehydrogenase E1 component alpha subu...   267  3e-71
ODPA_ASCSU (P26267) Pyruvate dehydrogenase E1 component alpha su...   262  6e-70
ODPT_ASCSU (P26268) Pyruvate dehydrogenase E1 component alpha su...   255  8e-68
ODPA_RHIME (Q9R9N5) Pyruvate dehydrogenase E1 component, alpha s...   220  3e-57
ODPA_ZYMMO (O66112) Pyruvate dehydrogenase E1 component, alpha s...   211  1e-54
ODPA_RICCN (Q92IS3) Pyruvate dehydrogenase E1 component, alpha s...   198  1e-50

>ODPA_PEA (P52902) Pyruvate dehydrogenase E1 component alpha
           subunit, mitochondrial precursor (EC 1.2.4.1) (PDHE1-A)
          Length = 397

 Score =  492 bits (1267), Expect = e-139
 Identities = 241/289 (83%), Positives = 261/289 (89%), Gaps = 4/289 (1%)

Query: 1   MALSRLASSSSSSSSTVGSKFLKPLTAAFSLRRSISSDSNP-ITIETSVPFTAHNCDPPS 59
           MALSRL+SSSSSS+   GS    P +AAF+L R ISSD+   +TIETS+PFTAHNCDPPS
Sbjct: 1   MALSRLSSSSSSSN---GSNLFNPFSAAFTLNRPISSDTTATLTIETSLPFTAHNCDPPS 57

Query: 60  RSVETSTAELHSFFRQMATMRRMEIAADSLYKAKLIRGFCHLYDGQEAVAIGMEAGITKK 119
           RSV TS +EL SFFR MA MRRMEIAADSLYKA LIRGFCHLYDGQEAVA+GMEAG TKK
Sbjct: 58  RSVTTSPSELLSFFRTMALMRRMEIAADSLYKANLIRGFCHLYDGQEAVAVGMEAGTTKK 117

Query: 120 DAIITAYRDHCTFLGRGGTLLEIFSELMGRVDGCSKGKGGSMHFYRKETNFYGGHGIVGA 179
           D IITAYRDHCTFLGRGGTLL +++ELMGR DGCSKGKGGSMHFY+K++ FYGGHGIVGA
Sbjct: 118 DCIITAYRDHCTFLGRGGTLLRVYAELMGRRDGCSKGKGGSMHFYKKDSGFYGGHGIVGA 177

Query: 180 QVPLGCGVAFAQKYSKDEAVTFALYGDGAANQGQLFEALNIAALWDLPAILVCENNHYGM 239
           QVPLGCG+AF QKY KDE+VTFALYGDGAANQGQLFEALNI+ALWDLPAILVCENNHYGM
Sbjct: 178 QVPLGCGLAFGQKYLKDESVTFALYGDGAANQGQLFEALNISALWDLPAILVCENNHYGM 237

Query: 240 GTAEWRAAKSPAYYKRGDYVPGLKVDGMDVLAVKQACKFAKEHALKNGP 288
           GTA WR+AKSPAY+KRGDYVPGLKVDGMD LAVKQACKFAKEHALKNGP
Sbjct: 238 GTATWRSAKSPAYFKRGDYVPGLKVDGMDALAVKQACKFAKEHALKNGP 286


>ODPA_ARATH (P52901) Pyruvate dehydrogenase E1 component alpha
           subunit, mitochondrial precursor (EC 1.2.4.1) (PDHE1-A)
          Length = 389

 Score =  477 bits (1228), Expect = e-134
 Identities = 236/288 (81%), Positives = 258/288 (88%), Gaps = 10/288 (3%)

Query: 1   MALSRLASSSSSSSSTVGSKFLKPLTAAFSLRRSISSDSNPITIETSVPFTAHNCDPPSR 60
           MALSRL+S S+  +        +P +AAFS  R IS+D+ PITIETS+PFTAH CDPPSR
Sbjct: 1   MALSRLSSRSNIIT--------RPFSAAFS--RLISTDTTPITIETSLPFTAHLCDPPSR 50

Query: 61  SVETSTAELHSFFRQMATMRRMEIAADSLYKAKLIRGFCHLYDGQEAVAIGMEAGITKKD 120
           SVE+S+ EL  FFR MA MRRMEIAADSLYKAKLIRGFCHLYDGQEAVAIGMEA ITKKD
Sbjct: 51  SVESSSQELLDFFRTMALMRRMEIAADSLYKAKLIRGFCHLYDGQEAVAIGMEAAITKKD 110

Query: 121 AIITAYRDHCTFLGRGGTLLEIFSELMGRVDGCSKGKGGSMHFYRKETNFYGGHGIVGAQ 180
           AIITAYRDHC FLGRGG+L E+FSELMGR  GCSKGKGGSMHFY+KE++FYGGHGIVGAQ
Sbjct: 111 AIITAYRDHCIFLGRGGSLHEVFSELMGRQAGCSKGKGGSMHFYKKESSFYGGHGIVGAQ 170

Query: 181 VPLGCGVAFAQKYSKDEAVTFALYGDGAANQGQLFEALNIAALWDLPAILVCENNHYGMG 240
           VPLGCG+AFAQKY+K+EAVTFALYGDGAANQGQLFEALNI+ALWDLPAILVCENNHYGMG
Sbjct: 171 VPLGCGIAFAQKYNKEEAVTFALYGDGAANQGQLFEALNISALWDLPAILVCENNHYGMG 230

Query: 241 TAEWRAAKSPAYYKRGDYVPGLKVDGMDVLAVKQACKFAKEHALKNGP 288
           TAEWRAAKSP+YYKRGDYVPGLKVDGMD  AVKQACKFAK+HAL+ GP
Sbjct: 231 TAEWRAAKSPSYYKRGDYVPGLKVDGMDAFAVKQACKFAKQHALEKGP 278


>ODPA_SOLTU (P52903) Pyruvate dehydrogenase E1 component alpha
           subunit, mitochondrial precursor (EC 1.2.4.1) (PDHE1-A)
          Length = 391

 Score =  462 bits (1188), Expect = e-130
 Identities = 223/277 (80%), Positives = 246/277 (88%), Gaps = 1/277 (0%)

Query: 13  SSSTVGSKFLKPLTAAFSLRRSISSDSNP-ITIETSVPFTAHNCDPPSRSVETSTAELHS 71
           S+S   +  +KPL+AA    R +SSDS   IT+ETS+PFT+HN DPPSRSVETS  EL +
Sbjct: 4   STSRAINHIMKPLSAAVCATRRLSSDSTATITVETSLPFTSHNIDPPSRSVETSPKELMT 63

Query: 72  FFRQMATMRRMEIAADSLYKAKLIRGFCHLYDGQEAVAIGMEAGITKKDAIITAYRDHCT 131
           FF+ M  MRRMEIAADSLYKAKLIRGFCHLYDGQEAVA+GMEA ITKKD IITAYRDHC 
Sbjct: 64  FFKDMTEMRRMEIAADSLYKAKLIRGFCHLYDGQEAVAVGMEAAITKKDCIITAYRDHCI 123

Query: 132 FLGRGGTLLEIFSELMGRVDGCSKGKGGSMHFYRKETNFYGGHGIVGAQVPLGCGVAFAQ 191
           FLGRGGTL+E F+ELMGR DGCS+GKGGSMHFY+KE+ FYGGHGIVGAQVPLG G+AFAQ
Sbjct: 124 FLGRGGTLVEAFAELMGRRDGCSRGKGGSMHFYKKESGFYGGHGIVGAQVPLGIGLAFAQ 183

Query: 192 KYSKDEAVTFALYGDGAANQGQLFEALNIAALWDLPAILVCENNHYGMGTAEWRAAKSPA 251
           KY K++ VTFA+YGDGAANQGQLFEALN+AALWDLPAILVCENNHYGMGTAEWRAAKSPA
Sbjct: 184 KYKKEDYVTFAMYGDGAANQGQLFEALNMAALWDLPAILVCENNHYGMGTAEWRAAKSPA 243

Query: 252 YYKRGDYVPGLKVDGMDVLAVKQACKFAKEHALKNGP 288
           YYKRGDYVPGL+VDGMDV AVKQAC FAK+HALKNGP
Sbjct: 244 YYKRGDYVPGLRVDGMDVFAVKQACTFAKQHALKNGP 280


>ODPA_SCHPO (Q10489) Pyruvate dehydrogenase E1 component alpha
           subunit, mitochondrial precursor (EC 1.2.4.1) (PDHE1-A)
          Length = 409

 Score =  281 bits (719), Expect = 1e-75
 Identities = 141/246 (57%), Positives = 175/246 (70%), Gaps = 3/246 (1%)

Query: 41  PITIETSVPFTAHNCDPPSRSVETSTAELHSFFRQMATMRRMEIAADSLYKAKLIRGFCH 100
           P+ ++ SV F  +  D PS  +E +  EL   + +M T+RR+E+A D+LYKAK IRGFCH
Sbjct: 51  PVKLDDSV-FEGYKIDVPSTEIEVTKGELLGLYEKMVTIRRLELACDALYKAKKIRGFCH 109

Query: 101 LYDGQEAVAIGMEAGITKKDAIITAYRDHCTFLGRGGTLLEIFSELMGRVDGCSKGKGGS 160
           L  GQEAVA G+E  IT  D+IIT+YR H     RG ++  I  ELMGR  G SKGKGGS
Sbjct: 110 LSIGQEAVAAGIEGAITLDDSIITSYRCHGFAYTRGLSIRSIIGELMGRQCGASKGKGGS 169

Query: 161 MHFYRKETNFYGGHGIVGAQVPLGCGVAFAQKYSKDEAVTFALYGDGAANQGQLFEALNI 220
           MH + K  NFYGG+GIVGAQ+PLG G+ FAQKY +    TFALYGDGA+NQGQ FEA N+
Sbjct: 170 MHIFAK--NFYGGNGIVGAQIPLGAGIGFAQKYLEKPTTTFALYGDGASNQGQAFEAFNM 227

Query: 221 AALWDLPAILVCENNHYGMGTAEWRAAKSPAYYKRGDYVPGLKVDGMDVLAVKQACKFAK 280
           A LW LP I  CENN YGMGT+  R++    +YKRG Y+PGL V+GMDVLAV QA KFAK
Sbjct: 228 AKLWGLPVIFACENNKYGMGTSAERSSAMTEFYKRGQYIPGLLVNGMDVLAVLQASKFAK 287

Query: 281 EHALKN 286
           ++ ++N
Sbjct: 288 KYTVEN 293


>ODPA_HUMAN (P08559) Pyruvate dehydrogenase E1 component alpha
           subunit, somatic form, mitochondrial precursor (EC
           1.2.4.1) (PDHE1-A type I)
          Length = 390

 Score =  277 bits (709), Expect = 2e-74
 Identities = 149/285 (52%), Positives = 185/285 (64%), Gaps = 29/285 (10%)

Query: 2   ALSRLASSSSSSSSTVGSKFLKPLTAAFSLRRSISSDSNPITIETSVPFTAHNCD----- 56
           A+SR+ S +S           KP +      R+ ++D+          F    CD     
Sbjct: 7   AVSRVLSGASQ----------KPASRVLVASRNFANDAT---------FEIKKCDLHRLE 47

Query: 57  --PPSRSVETSTAELHSFFRQMATMRRMEIAADSLYKAKLIRGFCHLYDGQEAVAIGMEA 114
             PP  +V T    L  ++R M T+RRME+ AD LYK K+IRGFCHL DGQEA  +G+EA
Sbjct: 48  EGPPVTTVLTREDGL-KYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEA 106

Query: 115 GITKKDAIITAYRDHCTFLGRGGTLLEIFSELMGRVDGCSKGKGGSMHFYRKETNFYGGH 174
           GI   D +ITAYR H     RG ++ EI +EL GR  GC+KGKGGSMH Y K  NFYGG+
Sbjct: 107 GINPTDHLITAYRAHGFTFTRGLSVREILAELTGRKGGCAKGKGGSMHMYAK--NFYGGN 164

Query: 175 GIVGAQVPLGCGVAFAQKYSKDEAVTFALYGDGAANQGQLFEALNIAALWDLPAILVCEN 234
           GIVGAQVPLG G+A A KY+  + V   LYGDGAANQGQ+FEA N+AALW LP I +CEN
Sbjct: 165 GIVGAQVPLGAGIALACKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICEN 224

Query: 235 NHYGMGTAEWRAAKSPAYYKRGDYVPGLKVDGMDVLAVKQACKFA 279
           N YGMGT+  RAA S  YYKRGD++PGL+VDGMD+L V++A +FA
Sbjct: 225 NRYGMGTSVERAAASTDYYKRGDFIPGLRVDGMDILCVREATRFA 269


>ODPA_YEAST (P16387) Pyruvate dehydrogenase E1 component alpha
           subunit, mitochondrial precursor (EC 1.2.4.1) (PDHE1-A)
          Length = 420

 Score =  276 bits (707), Expect = 3e-74
 Identities = 139/250 (55%), Positives = 178/250 (70%), Gaps = 6/250 (2%)

Query: 43  TIETSVP---FTAHNCDPPSRSVETSTAELHSFFRQMATMRRMEIAADSLYKAKLIRGFC 99
           T++  +P   F ++  +PP  S ETS A L   ++ M  +RRME+A D+LYKAK IRGFC
Sbjct: 52  TVQIELPESSFESYMLEPPDLSYETSKATLLQMYKDMVIIRRMEMACDALYKAKKIRGFC 111

Query: 100 HLYDGQEAVAIGMEAGITKKDAIITAYRDHCTFLGRGGTLLEIFSELMGRVDGCSKGKGG 159
           HL  GQEA+A+G+E  ITK D+IIT+YR H     RG ++  + +ELMGR  G S GKGG
Sbjct: 112 HLSVGQEAIAVGIENAITKLDSIITSYRCHGFTFMRGASVKAVLAELMGRRAGVSYGKGG 171

Query: 160 SMHFYRKETNFYGGHGIVGAQVPLGCGVAFAQKYSKDEAVTFALYGDGAANQGQLFEALN 219
           SMH Y     FYGG+GIVGAQVPLG G+AFA +Y  ++A +F LYGDGA+NQGQ+FE+ N
Sbjct: 172 SMHLYAP--GFYGGNGIVGAQVPLGAGLAFAHQYKNEDACSFTLYGDGASNQGQVFESFN 229

Query: 220 IAALWDLPAILVCENNHYGMGTAEWRAAKSPAYYKRGDYVPGLKVDGMDVLAVKQACKFA 279
           +A LW+LP +  CENN YGMGTA  R++    Y+KRG Y+PGLKV+GMD+LAV QA KFA
Sbjct: 230 MAKLWNLPVVFCCENNKYGMGTAASRSSAMTEYFKRGQYIPGLKVNGMDILAVYQASKFA 289

Query: 280 KEHALK-NGP 288
           K+  L   GP
Sbjct: 290 KDWCLSGKGP 299


>ODPA_SMIMA (P52900) Pyruvate dehydrogenase E1 component alpha
           subunit, mitochondrial precursor (EC 1.2.4.1) (PDHE1-A)
           (Fragment)
          Length = 363

 Score =  276 bits (707), Expect = 3e-74
 Identities = 137/223 (61%), Positives = 166/223 (74%), Gaps = 3/223 (1%)

Query: 57  PPSRSVETSTAELHSFFRQMATMRRMEIAADSLYKAKLIRGFCHLYDGQEAVAIGMEAGI 116
           PP+ +V T    L  +++ M T+RRME+ AD LYK K+IRGFCHLYDGQEA  +G+EAGI
Sbjct: 23  PPTTAVLTREEGL-KYYKIMQTVRRMELKADQLYKQKIIRGFCHLYDGQEACCMGLEAGI 81

Query: 117 TKKDAIITAYRDHCTFLGRGGTLLEIFSELMGRVDGCSKGKGGSMHFYRKETNFYGGHGI 176
              D +ITAYR H     RG  + EI +EL GR  GC+KGKGGSMH Y K  NFYGG+GI
Sbjct: 82  NPTDHVITAYRAHGFTYTRGLPVREILAELTGRRGGCAKGKGGSMHMYAK--NFYGGNGI 139

Query: 177 VGAQVPLGCGVAFAQKYSKDEAVTFALYGDGAANQGQLFEALNIAALWDLPAILVCENNH 236
           VGAQVPLG G+A A KY++ + +   LYGDGAANQGQ+FEA N+AALW LP I +CENN 
Sbjct: 140 VGAQVPLGVGIALACKYNEKDEICLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNR 199

Query: 237 YGMGTAEWRAAKSPAYYKRGDYVPGLKVDGMDVLAVKQACKFA 279
           YGMGT+  RAA S  YYKRGD++PG+ VDGMDVL V++A KFA
Sbjct: 200 YGMGTSVERAAASTDYYKRGDFIPGIMVDGMDVLCVREATKFA 242


>ODPA_RAT (P26284) Pyruvate dehydrogenase E1 component alpha
           subunit, somatic form, mitochondrial precursor (EC
           1.2.4.1) (PDHE1-A type I)
          Length = 390

 Score =  276 bits (705), Expect = 5e-74
 Identities = 143/264 (54%), Positives = 175/264 (66%), Gaps = 19/264 (7%)

Query: 23  KPLTAAFSLRRSISSDSNPITIETSVPFTAHNCD-------PPSRSVETSTAELHSFFRQ 75
           KP +      R+ ++D+          F    CD       PP  +V T    L  ++R 
Sbjct: 18  KPASRVLVASRNFANDAT---------FEIKKCDLHRLEEGPPVTTVLTREDGL-KYYRM 67

Query: 76  MATMRRMEIAADSLYKAKLIRGFCHLYDGQEAVAIGMEAGITKKDAIITAYRDHCTFLGR 135
           M T+RRME+ AD LYK K+IRGFCHL DGQEA  +G+EAGI   D +ITAYR H     R
Sbjct: 68  MQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRAHGFTFNR 127

Query: 136 GGTLLEIFSELMGRVDGCSKGKGGSMHFYRKETNFYGGHGIVGAQVPLGCGVAFAQKYSK 195
           G  +  + +EL GR  GC+KGKGGSMH Y K  NFYGG+GIVGAQVPLG G+A A KY+ 
Sbjct: 128 GHAVRAVLAELTGRRGGCAKGKGGSMHMYAK--NFYGGNGIVGAQVPLGAGIALACKYNG 185

Query: 196 DEAVTFALYGDGAANQGQLFEALNIAALWDLPAILVCENNHYGMGTAEWRAAKSPAYYKR 255
            + V   LYGDGAANQGQ+FEA N+AALW LP I +CENN YGMGT+  RAA S  YYKR
Sbjct: 186 KDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTSVERAAASTDYYKR 245

Query: 256 GDYVPGLKVDGMDVLAVKQACKFA 279
           GD++PGL+VDGMD+L V++A KFA
Sbjct: 246 GDFIPGLRVDGMDILCVREATKFA 269


>ODPA_PIG (P29804) Pyruvate dehydrogenase E1 component alpha
           subunit, somatic form, mitochondrial precursor (EC
           1.2.4.1) (PDHE1-A type I) (Fragment)
          Length = 389

 Score =  276 bits (705), Expect = 5e-74
 Identities = 140/244 (57%), Positives = 168/244 (68%), Gaps = 10/244 (4%)

Query: 43  TIETSVPFTAHNCD-------PPSRSVETSTAELHSFFRQMATMRRMEIAADSLYKAKLI 95
           T      F    CD       PP  +V T    L  ++R M T+RRME+ AD LYK K+I
Sbjct: 28  TFANDATFEIKKCDLHRLEEGPPVTTVLTREDGL-KYYRMMQTVRRMELKADQLYKQKII 86

Query: 96  RGFCHLYDGQEAVAIGMEAGITKKDAIITAYRDHCTFLGRGGTLLEIFSELMGRVDGCSK 155
           RGFCHL DGQEA  +G+EAGI   D +ITAYR H     RG ++ EI +EL GR  GC K
Sbjct: 87  RGFCHLCDGQEACCVGLEAGINPTDHLITAYRAHGFTFTRGLSVREILAELTGRRGGCGK 146

Query: 156 GKGGSMHFYRKETNFYGGHGIVGAQVPLGCGVAFAQKYSKDEAVTFALYGDGAANQGQLF 215
           GKGGSMH Y K  NFYGG+GIVGAQVPLG G+A A KY+  + V   LYGDGAANQGQ+F
Sbjct: 147 GKGGSMHMYAK--NFYGGNGIVGAQVPLGAGIALACKYNGKDEVCLTLYGDGAANQGQIF 204

Query: 216 EALNIAALWDLPAILVCENNHYGMGTAEWRAAKSPAYYKRGDYVPGLKVDGMDVLAVKQA 275
           EA N+AALW LP + +CENN YGMGT+  RAA S  YYKRGD++PGL+VDGMD+L V++A
Sbjct: 205 EAYNMAALWKLPCVFICENNRYGMGTSVERAAASTDYYKRGDFIPGLRVDGMDILCVREA 264

Query: 276 CKFA 279
            +FA
Sbjct: 265 TRFA 268


>ODPA_MOUSE (P35486) Pyruvate dehydrogenase E1 component alpha
           subunit, somatic form, mitochondrial precursor (EC
           1.2.4.1) (PDHE1-A type I)
          Length = 390

 Score =  274 bits (701), Expect = 2e-73
 Identities = 144/264 (54%), Positives = 175/264 (65%), Gaps = 19/264 (7%)

Query: 23  KPLTAAFSLRRSISSDSNPITIETSVPFTAHNCD-------PPSRSVETSTAELHSFFRQ 75
           KP +      R+ ++D+          F    CD       PP  +V T    L  ++R 
Sbjct: 18  KPASRVLVASRNFANDAT---------FEIKKCDLHRLEEGPPVTTVLTREDGL-KYYRM 67

Query: 76  MATMRRMEIAADSLYKAKLIRGFCHLYDGQEAVAIGMEAGITKKDAIITAYRDHCTFLGR 135
           M T+RRME+ AD LYK K+IRGFCHL DGQEA  +G+EAGI   D +ITAYR H     R
Sbjct: 68  MQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRAHGFTFTR 127

Query: 136 GGTLLEIFSELMGRVDGCSKGKGGSMHFYRKETNFYGGHGIVGAQVPLGCGVAFAQKYSK 195
           G  +  I +EL GR  GC+KGKGGSMH Y K  NFYGG+GIVGAQVPLG G+A A KY+ 
Sbjct: 128 GLPVRAILAELTGRRGGCAKGKGGSMHMYAK--NFYGGNGIVGAQVPLGAGIALACKYNG 185

Query: 196 DEAVTFALYGDGAANQGQLFEALNIAALWDLPAILVCENNHYGMGTAEWRAAKSPAYYKR 255
            + V   LYGDGAANQGQ+FEA N+AALW LP I +CENN YGMGT+  RAA S  YYKR
Sbjct: 186 KDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTSVERAAASTDYYKR 245

Query: 256 GDYVPGLKVDGMDVLAVKQACKFA 279
           GD++PGL+VDGMD+L V++A KFA
Sbjct: 246 GDFIPGLRVDGMDILCVREATKFA 269


>ODPT_HUMAN (P29803) Pyruvate dehydrogenase E1 component alpha
           subunit, testis-specific form, mitochondrial precursor
           (EC 1.2.4.1) (PDHE1-A type II)
          Length = 388

 Score =  272 bits (695), Expect = 8e-73
 Identities = 143/260 (55%), Positives = 174/260 (66%), Gaps = 13/260 (5%)

Query: 30  SLRRSISSDSNPITIETSVPFTAHNCD-------PPSRSVETSTAELHSFFRQMATMRRM 82
           S RR + +  N     T   F    CD       PP  +V T  AE   ++R M T+RRM
Sbjct: 17  SARRVLVASRNSSNDAT---FEIKKCDLYLLEEGPPVTTVLTR-AEGLKYYRMMLTVRRM 72

Query: 83  EIAADSLYKAKLIRGFCHLYDGQEAVAIGMEAGITKKDAIITAYRDHCTFLGRGGTLLEI 142
           E+ AD LYK K IRGFCHL DGQEA  +G+EAGI   D +IT+YR H     RG ++  I
Sbjct: 73  ELKADQLYKQKFIRGFCHLCDGQEACCVGLEAGINPSDHVITSYRAHGVCYTRGLSVRSI 132

Query: 143 FSELMGRVDGCSKGKGGSMHFYRKETNFYGGHGIVGAQVPLGCGVAFAQKYSKDEAVTFA 202
            +EL GR  GC+KGKGGSMH Y K  NFYGG+GIVGAQ PLG G+A A KY  ++ +   
Sbjct: 133 LAELTGRRGGCAKGKGGSMHMYTK--NFYGGNGIVGAQGPLGAGIALACKYKGNDEICLT 190

Query: 203 LYGDGAANQGQLFEALNIAALWDLPAILVCENNHYGMGTAEWRAAKSPAYYKRGDYVPGL 262
           LYGDGAANQGQ+ EA N+AALW LP + +CENN YGMGT+  RAA SP YYKRG+++PGL
Sbjct: 191 LYGDGAANQGQIAEAFNMAALWKLPCVFICENNLYGMGTSTERAAASPDYYKRGNFIPGL 250

Query: 263 KVDGMDVLAVKQACKFAKEH 282
           KVDGMDVL V++A KFA  +
Sbjct: 251 KVDGMDVLCVREATKFAANY 270


>ODPA_KLULA (O13366) Pyruvate dehydrogenase E1 component alpha
           subunit, mitochondrial precursor (EC 1.2.4.1) (PDHE1-A)
          Length = 412

 Score =  271 bits (693), Expect = 1e-72
 Identities = 137/245 (55%), Positives = 175/245 (70%), Gaps = 5/245 (2%)

Query: 45  ETSVPFTAHNCDPPSRSVETSTAELHSFFRQMATMRRMEIAADSLYKAKLIRGFCHLYDG 104
           ETS  F  +  D P  S +T+ + L   ++ M  +RRME+A D+LYKAK IRGFCH   G
Sbjct: 51  ETS--FEGYLLDVPELSYQTTKSNLLQMYKDMIIVRRMEMACDALYKAKKIRGFCHSSVG 108

Query: 105 QEAVAIGMEAGITKKDAIITAYRDHCTFLGRGGTLLEIFSELMGRVDGCSKGKGGSMHFY 164
           QEA+A+G+E  ITK+D +IT+YR H     RG  +  + +ELMGR  G S GKGGSMH Y
Sbjct: 109 QEAIAVGIENAITKRDTVITSYRCHGFTYMRGAAVQAVLAELMGRRTGVSFGKGGSMHLY 168

Query: 165 RKETNFYGGHGIVGAQVPLGCGVAFAQKYSKDEAVTFALYGDGAANQGQLFEALNIAALW 224
                FYGG+GIVGAQVPLG G+AFA +Y  ++A +FALYGDGA+NQGQ+FE+ N+A LW
Sbjct: 169 AP--GFYGGNGIVGAQVPLGAGLAFAHQYKHEDACSFALYGDGASNQGQVFESFNMAKLW 226

Query: 225 DLPAILVCENNHYGMGTAEWRAAKSPAYYKRGDYVPGLKVDGMDVLAVKQACKFAKEHAL 284
           +LPA+  CENN YGMGTA  R++    Y+KRG Y+PGLKV+GMD+LAV QA KFAK+  +
Sbjct: 227 NLPAVFCCENNKYGMGTAAARSSAMTEYFKRGQYIPGLKVNGMDILAVYQASKFAKDWTV 286

Query: 285 K-NGP 288
             NGP
Sbjct: 287 SGNGP 291


>ODPA_CAEEL (P52899) Probable pyruvate dehydrogenase E1 component
           alpha subunit, mitochondrial precursor (EC 1.2.4.1)
           (PDHE1-A)
          Length = 397

 Score =  271 bits (693), Expect = 1e-72
 Identities = 143/262 (54%), Positives = 178/262 (67%), Gaps = 4/262 (1%)

Query: 22  LKPLTAAFSLRRSISSDSNPITIETSVPFTAHNCDP-PSRSVETSTAELHSFFRQMATMR 80
           L+ LTA+    + +   S  ++  T  P   H  D  P+ SV  +  +   ++R M  +R
Sbjct: 8   LQSLTASGIRTQQVRLASTEVSFHTK-PCKLHKLDNGPNTSVTLNREDALKYYRDMQVIR 66

Query: 81  RMEIAADSLYKAKLIRGFCHLYDGQEAVAIGMEAGITKKDAIITAYRDHCTFLGRGGTLL 140
           RME AA +LYK K IRGFCHLY GQEA A+GM+A +T+ DA+ITAYR H      G T+ 
Sbjct: 67  RMESAAGNLYKEKKIRGFCHLYSGQEACAVGMKAAMTEGDAVITAYRCHGWTWLLGATVT 126

Query: 141 EIFSELMGRVDGCSKGKGGSMHFYRKETNFYGGHGIVGAQVPLGCGVAFAQKYSKDEAVT 200
           E+ +EL GRV G   GKGGSMH Y K  NFYGG+GIVGAQ PLG GVA A KY + + V 
Sbjct: 127 EVLAELTGRVAGNVHGKGGSMHMYTK--NFYGGNGIVGAQQPLGAGVALAMKYREQKNVC 184

Query: 201 FALYGDGAANQGQLFEALNIAALWDLPAILVCENNHYGMGTAEWRAAKSPAYYKRGDYVP 260
             LYGDGAANQGQLFEA N+A LWDLP + VCENN +GMGT   R++ S  YY RGDYVP
Sbjct: 185 VTLYGDGAANQGQLFEATNMAKLWDLPVLFVCENNGFGMGTTAERSSASTEYYTRGDYVP 244

Query: 261 GLKVDGMDVLAVKQACKFAKEH 282
           G+ VDGMD+LAV++A K+AKE+
Sbjct: 245 GIWVDGMDILAVREATKWAKEY 266


>ODPT_MOUSE (P35487) Pyruvate dehydrogenase E1 component alpha
           subunit, testis-specific form, mitochondrial precursor
           (EC 1.2.4.1) (PDHE1-A type II)
          Length = 391

 Score =  269 bits (687), Expect = 7e-72
 Identities = 134/226 (59%), Positives = 166/226 (73%), Gaps = 3/226 (1%)

Query: 57  PPSRSVETSTAELHSFFRQMATMRRMEIAADSLYKAKLIRGFCHLYDGQEAVAIGMEAGI 116
           PP+ +V T  AE   ++R M  +RRME+ AD LYK K IRGFCHL DGQEA  +G+EAGI
Sbjct: 51  PPTSTVLTR-AEALKYYRTMQVIRRMELKADQLYKQKFIRGFCHLCDGQEACCVGLEAGI 109

Query: 117 TKKDAIITAYRDHCTFLGRGGTLLEIFSELMGRVDGCSKGKGGSMHFYRKETNFYGGHGI 176
              D +IT+YR H     RG ++  I +EL GR  GC+KGKGGSMH Y K  NFYGG+GI
Sbjct: 110 NPTDHVITSYRAHGFCYTRGLSVKSILAELTGRKGGCAKGKGGSMHMYGK--NFYGGNGI 167

Query: 177 VGAQVPLGCGVAFAQKYSKDEAVTFALYGDGAANQGQLFEALNIAALWDLPAILVCENNH 236
           VGAQVPLG GVAFA KY K+  V  ALYGDGAANQGQ+FEA N++ALW LP + +CENN 
Sbjct: 168 VGAQVPLGAGVAFACKYLKNGQVCLALYGDGAANQGQVFEAYNMSALWKLPCVFICENNL 227

Query: 237 YGMGTAEWRAAKSPAYYKRGDYVPGLKVDGMDVLAVKQACKFAKEH 282
           YGMGT+  R+A S  Y+K+G  +PGL+V+GMD+L V++A KFA +H
Sbjct: 228 YGMGTSNERSAASTDYHKKGFIIPGLRVNGMDILCVREATKFAADH 273


>ODPT_RAT (Q06437) Pyruvate dehydrogenase E1 component alpha
           subunit, testis-specific form, mitochondrial precursor
           (EC 1.2.4.1) (PDHE1-A type II)
          Length = 391

 Score =  267 bits (682), Expect = 3e-71
 Identities = 133/226 (58%), Positives = 165/226 (72%), Gaps = 3/226 (1%)

Query: 57  PPSRSVETSTAELHSFFRQMATMRRMEIAADSLYKAKLIRGFCHLYDGQEAVAIGMEAGI 116
           PP+ +V T    L  ++R M  +RRME+ AD LYK K IRGFCHL DGQEA  +G+EAGI
Sbjct: 51  PPTSTVLTREEAL-KYYRNMQVIRRMELKADQLYKQKFIRGFCHLCDGQEACNVGLEAGI 109

Query: 117 TKKDAIITAYRDHCTFLGRGGTLLEIFSELMGRVDGCSKGKGGSMHFYRKETNFYGGHGI 176
              D IIT+YR H     RG ++  I +EL GR  GC+KGKGGSMH Y K  NFYGG+GI
Sbjct: 110 NPTDHIITSYRAHGLCYTRGLSVKSILAELTGRKGGCAKGKGGSMHMYAK--NFYGGNGI 167

Query: 177 VGAQVPLGCGVAFAQKYSKDEAVTFALYGDGAANQGQLFEALNIAALWDLPAILVCENNH 236
           VGAQVPLG GVA A KY K+  +  ALYGDGAANQGQ+FEA N++ALW LP + +CENN 
Sbjct: 168 VGAQVPLGAGVALACKYLKNGQICLALYGDGAANQGQVFEAYNMSALWKLPCVFICENNR 227

Query: 237 YGMGTAEWRAAKSPAYYKRGDYVPGLKVDGMDVLAVKQACKFAKEH 282
           YGMGTA  R+A S  Y+K+G  +PGL+V+GMD+L+V++A KFA +H
Sbjct: 228 YGMGTAIERSAASTDYHKKGFVIPGLRVNGMDILSVREATKFAADH 273


>ODPA_ASCSU (P26267) Pyruvate dehydrogenase E1 component alpha
           subunit type I, mitochondrial precursor (EC 1.2.4.1)
           (PDHE1-A)
          Length = 396

 Score =  262 bits (670), Expect = 6e-70
 Identities = 136/262 (51%), Positives = 174/262 (65%), Gaps = 4/262 (1%)

Query: 21  FLKPLTAAFSLRRSISSDSNPITIETSVPFTAHNCDP-PSRSVETSTAELHSFFRQMATM 79
           F  P  +   +  S+   S   T +T  PF  H  D  P  +V  +  +   ++ QM T+
Sbjct: 9   FKVPTVSPSVMAISVRLASTEATFQTK-PFKLHKLDSGPDINVHVTKEDAVHYYTQMLTI 67

Query: 80  RRMEIAADSLYKAKLIRGFCHLYDGQEAVAIGMEAGITKKDAIITAYRDHCTFLGRGGTL 139
           RRME AA +LYK K +RGFCHLY GQEA A+G +A +   DA +TAYR H      G ++
Sbjct: 68  RRMESAAGNLYKEKKVRGFCHLYSGQEACAVGTKAAMDAGDAAVTAYRCHGWTYLSGSSV 127

Query: 140 LEIFSELMGRVDGCSKGKGGSMHFYRKETNFYGGHGIVGAQVPLGCGVAFAQKYSKDEAV 199
            ++  EL GR+ G   GKGGSMH Y +  NFYGG+GIVGAQ PLG G+AFA KY K++ V
Sbjct: 128 AKVLCELTGRITGNVYGKGGSMHMYGE--NFYGGNGIVGAQQPLGTGIAFAMKYRKEKNV 185

Query: 200 TFALYGDGAANQGQLFEALNIAALWDLPAILVCENNHYGMGTAEWRAAKSPAYYKRGDYV 259
              ++GDGA NQGQLFE++N+A LWDLP + VCENN YGMGTA  R++ S  YY RGDYV
Sbjct: 186 CITMFGDGATNQGQLFESMNMAKLWDLPVLYVCENNGYGMGTAAARSSASTDYYTRGDYV 245

Query: 260 PGLKVDGMDVLAVKQACKFAKE 281
           PG+ VDGMDVLAV+QA ++AKE
Sbjct: 246 PGIWVDGMDVLAVRQAVRWAKE 267


>ODPT_ASCSU (P26268) Pyruvate dehydrogenase E1 component alpha
           subunit type II, mitochondrial precursor (EC 1.2.4.1)
           (PDHE1-A) (Fragment)
          Length = 391

 Score =  255 bits (652), Expect = 8e-68
 Identities = 128/234 (54%), Positives = 161/234 (68%), Gaps = 3/234 (1%)

Query: 49  PFTAHNCDP-PSRSVETSTAELHSFFRQMATMRRMEIAADSLYKAKLIRGFCHLYDGQEA 107
           PF  H  D  P  ++  +  +   ++ QM T+RRME AA +LYK K +RGFCHLY GQEA
Sbjct: 31  PFKLHKLDSGPDVNMHVTKEDALRYYTQMQTIRRMETAAGNLYKEKKVRGFCHLYSGQEA 90

Query: 108 VAIGMEAGITKKDAIITAYRDHCTFLGRGGTLLEIFSELMGRVDGCSKGKGGSMHFYRKE 167
            A+GM+A +   DA ITAYR H      G  + ++  EL GR+ G   GKGGSMH Y + 
Sbjct: 91  CAVGMKAAMEPGDAAITAYRCHGWTYLSGSPVAKVLCELTGRITGNVYGKGGSMHMYGE- 149

Query: 168 TNFYGGHGIVGAQVPLGCGVAFAQKYSKDEAVTFALYGDGAANQGQLFEALNIAALWDLP 227
            NFYGG+GIVGAQ PLG G+AFA KY K + V   L+GDGA NQGQL+E++N+A LW+LP
Sbjct: 150 -NFYGGNGIVGAQQPLGTGIAFAMKYKKQKNVCITLFGDGATNQGQLYESMNMAKLWELP 208

Query: 228 AILVCENNHYGMGTAEWRAAKSPAYYKRGDYVPGLKVDGMDVLAVKQACKFAKE 281
            + VCENN YGMGT+  R++ S  YY RGDYVPG  VDGMDVLAV+QA ++ KE
Sbjct: 209 VLYVCENNGYGMGTSAARSSASTDYYTRGDYVPGFWVDGMDVLAVRQAIRWGKE 262


>ODPA_RHIME (Q9R9N5) Pyruvate dehydrogenase E1 component, alpha
           subunit (EC 1.2.4.1)
          Length = 348

 Score =  220 bits (561), Expect = 3e-57
 Identities = 112/212 (52%), Positives = 142/212 (66%), Gaps = 2/212 (0%)

Query: 73  FRQMATMRRMEIAADSLYKAKLIRGFCHLYDGQEAVAIGMEAGITKKDAIITAYRDHCTF 132
           +R+M  +RR E  A  LY    I GFCHLY GQEAV +GM+  + + D +IT YRDH   
Sbjct: 40  YREMLLIRRFEEKAGQLYGMGFIGGFCHLYIGQEAVVVGMQLALKEGDQVITGYRDHGHM 99

Query: 133 LGRGGTLLEIFSELMGRVDGCSKGKGGSMHFYRKETNFYGGHGIVGAQVPLGCGVAFAQK 192
           L  G +   + +EL GR  G SKGKGGSMH + KE +FYGGHGIVGAQV LG G+AFA +
Sbjct: 100 LACGMSARGVMAELTGRRGGLSKGKGGSMHMFSKEKHFYGGHGIVGAQVSLGTGLAFANR 159

Query: 193 YSKDEAVTFALYGDGAANQGQLFEALNIAALWDLPAILVCENNHYGMGTAEWRAAKSPAY 252
           Y  ++ V+ A +GDGAANQGQ++E+ N+AALW LP I + ENN Y MGT+  RA+    +
Sbjct: 160 YRGNDNVSLAYFGDGAANQGQVYESFNMAALWKLPVIYIVENNRYAMGTSVSRASAQTDF 219

Query: 253 YKRGDY--VPGLKVDGMDVLAVKQACKFAKEH 282
            +RG    +PG +VDGMDV AVK A   A EH
Sbjct: 220 SQRGASFGIPGYQVDGMDVRAVKAAADEAVEH 251


>ODPA_ZYMMO (O66112) Pyruvate dehydrogenase E1 component, alpha
           subunit (EC 1.2.4.1)
          Length = 354

 Score =  211 bits (538), Expect = 1e-54
 Identities = 118/248 (47%), Positives = 148/248 (59%), Gaps = 4/248 (1%)

Query: 36  SSDSN-PITIETSVPFTAHNCDPPSRSVETSTAELHSFFRQMATMRRMEIAADSLYKAKL 94
           + DSN P   +       H+  P          EL  F+R+M  +RR E     LY   L
Sbjct: 5   TQDSNRPHKADVGSAIPNHDLPPIPGRYHADREELLEFYRRMLMIRRFEERCGQLYGLGL 64

Query: 95  IRGFCHLYDGQEAVAIGMEAGITK-KDAIITAYRDHCTFLGRGGTLLEIFSELMGRVDGC 153
           I GFCHLY GQEAVA+G++A +   +D++IT YR+H   L  G     + +EL GR  G 
Sbjct: 65  IAGFCHLYIGQEAVAVGLQAALQPGRDSVITGYREHGHMLAYGIDPKIVMAELTGRASGI 124

Query: 154 SKGKGGSMHFYRKETNFYGGHGIVGAQVPLGCGVAFAQKYSKDEAVTFALYGDGAANQGQ 213
           S GKGGSMH +  E  F+GG+GIVGAQVPLG G+AFA KY  D   + A +GDG+ANQGQ
Sbjct: 125 SHGKGGSMHMFSTEHKFFGGNGIVGAQVPLGAGLAFAHKYRNDGGCSAAYFGDGSANQGQ 184

Query: 214 LFEALNIAALWDLPAILVCENNHYGMGTAEWRAAKSPAYYKRGD--YVPGLKVDGMDVLA 271
           ++EA N+AALW LP I V ENN Y MGT+  RA    A  +RG    +P L VDGMDVL 
Sbjct: 185 VYEAYNMAALWKLPVIFVIENNGYAMGTSIQRANAHTALSERGAGFGIPALVVDGMDVLE 244

Query: 272 VKQACKFA 279
           V+ A   A
Sbjct: 245 VRGAATVA 252


>ODPA_RICCN (Q92IS3) Pyruvate dehydrogenase E1 component, alpha
           subunit (EC 1.2.4.1)
          Length = 326

 Score =  198 bits (504), Expect = 1e-50
 Identities = 101/216 (46%), Positives = 130/216 (59%), Gaps = 2/216 (0%)

Query: 73  FRQMATMRRMEIAADSLYKAKLIRGFCHLYDGQEAVAIGMEAGITKKDAIITAYRDHCTF 132
           F+ M  +RR E     LY    I GFCHLY GQEAV   ++    K D+ IT+YRDH   
Sbjct: 19  FKDMLLLRRFEEKCGQLYGMGEIGGFCHLYIGQEAVISAIDMVKQKGDSTITSYRDHAHI 78

Query: 133 LGRGGTLLEIFSELMGRVDGCSKGKGGSMHFYRKETNFYGGHGIVGAQVPLGCGVAFAQK 192
           +  G     + +ELMGR  GCSKGKGGSMH +     FYGGHGIVGAQVP+G G+AF +K
Sbjct: 79  ILAGTEPKYVLAELMGRATGCSKGKGGSMHLFNVPNKFYGGHGIVGAQVPIGTGLAFVEK 138

Query: 193 YSKDEAVTFALYGDGAANQGQLFEALNIAALWDLPAILVCENNHYGMGTAEWRAAKSPAY 252
           Y+    + F   GDGA NQGQ++EA N+AALW LP + + ENN Y MGT+  R+      
Sbjct: 139 YNDTHNICFTFLGDGAVNQGQVYEAFNMAALWGLPVVYIIENNEYSMGTSVARSTFMRDL 198

Query: 253 YKRGDY--VPGLKVDGMDVLAVKQACKFAKEHALKN 286
           YK+G    + G ++DGMD   +    K A E+  +N
Sbjct: 199 YKKGASFGIKGFQLDGMDFEEMYDGSKQAAEYVREN 234


  Database: sprot
    Posted date:  Nov 25, 2004 10:54 AM
  Number of letters in database: 59,974,054
  Number of sequences in database:  164,201
  
Lambda     K      H
   0.319    0.134    0.397 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,321,586
Number of Sequences: 164201
Number of extensions: 1423095
Number of successful extensions: 3687
Number of sequences better than 10.0: 127
Number of HSP's better than 10.0 without gapping: 87
Number of HSP's successfully gapped in prelim test: 41
Number of HSP's that attempted gapping in prelim test: 3489
Number of HSP's gapped (non-prelim): 164
length of query: 288
length of database: 59,974,054
effective HSP length: 109
effective length of query: 179
effective length of database: 42,076,145
effective search space: 7531629955
effective search space used: 7531629955
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)