BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= TM0012b.5
(815 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
MSS4_YEAST (P38994) Probable phosphatidylinositol-4-phosphate 5-... 191 9e-48
PI5B_MOUSE (Q80XI4) Phosphatidylinositol-4-phosphate 5-kinase ty... 141 6e-33
PI52_HUMAN (P48426) Phosphatidylinositol-4-phosphate 5-kinase ty... 141 8e-33
PI52_MOUSE (O70172) Phosphatidylinositol-4-phosphate 5-kinase ty... 140 2e-32
PI5B_HUMAN (P78356) Phosphatidylinositol-4-phosphate 5-kinase ty... 139 2e-32
PI53_HUMAN (P53807) Phosphatidylinositol-4-phosphate 5-kinase ty... 135 4e-31
PI5B_RAT (O88377) Phosphatidylinositol-4-phosphate 5-kinase type... 129 4e-29
TSA2_MOUSE (Q8VIG3) Testis-specific gene A2 (Male meiotic metaph... 90 2e-17
TSA2_HUMAN (Q8WYR4) Testis-specific gene A2 (Male meiotic metaph... 89 4e-17
JPH3_MOUSE (Q9ET77) Junctophilin 3 (Junctophilin type 3) (JP-3) 85 7e-16
JPH3_HUMAN (Q8WXH2) Junctophilin 3 (Junctophilin type 3) (JP-3) 85 7e-16
JPH2_RABIT (Q9GKY7) Junctophilin 2 (Junctophilin type 2) (JP-2) 81 1e-14
JPH2_MOUSE (Q9ET78) Junctophilin 2 (Junctophilin type 2) (JP-2) 80 2e-14
JPH2_HUMAN (Q9BR39) Junctophilin 2 (Junctophilin type 2) (JP-2) 80 2e-14
JPH1_RABIT (Q9GKY8) Junctophilin 1 (Junctophilin type 1) (JP-1) ... 79 5e-14
JPH1_MOUSE (Q9ET80) Junctophilin 1 (Junctophilin type 1) (JP-1) 79 5e-14
JPH1_HUMAN (Q9HDC5) Junctophilin 1 (Junctophilin type 1) (JP-1) 79 5e-14
JPH4_MOUSE (Q80WT0) Junctophilin 4 (Junctophilin-like 1 protein) 78 1e-13
JPH4_HUMAN (Q96JJ6) Junctophilin 4 (Junctophilin-like 1 protein) 78 1e-13
FYV1_HUMAN (Q9Y2I7) FYVE finger-containing phosphoinositide kina... 74 2e-12
>MSS4_YEAST (P38994) Probable phosphatidylinositol-4-phosphate
5-kinase MSS4 (EC 2.7.1.68)
(1-phosphatidylinositol-4-phosphate kinase) (PIP5K)
(PtdIns(4)P-5-kinase) (Diphosphoinositide kinase)
Length = 779
Score = 191 bits (484), Expect = 9e-48
Identities = 146/448 (32%), Positives = 224/448 (49%), Gaps = 83/448 (18%)
Query: 381 GEAIIKGHRSYDLMLSLQLGIRYTVGKITPVPRREVRASDFGSKASFWMNFPREGSPLTP 440
G + +GH ++ + ++ GIR V + + + + + +DF + + + F G+ LTP
Sbjct: 376 GNKVSEGHVNFIIAYNMLTGIRVAVSRCSGI-MKPLTPADF--RFTKKLAFDYHGNELTP 432
Query: 441 SHQSEDFKWKDYCPMVFRNLRELFKIDAADYMISICGNDALRELSSPGKSGSVFFLSQDD 500
S Q FK+KDYCP VFR LR LF +D ADY++S+ L EL+SPGKSGS F+ S+D
Sbjct: 433 SSQYA-FKFKDYCPEVFRELRALFGLDPADYLVSLTSKYILSELNSPGKSGSFFYYSRDY 491
Query: 501 RFMIKTLRKSELKIFLRMLPDYHHHVKSYENTLITKFFGLHRIK-PSSGQ------KFRF 553
+++IKT+ SE + + +Y++HV+ NTLI +F+GLHR+K P S Q K F
Sbjct: 492 KYIIKTIHHSEHIHLRKHIQEYYNHVRDNPNTLICQFYGLHRVKMPISFQNKIKHRKIYF 551
Query: 554 AVMGNMFCTELRIHRRFDLKGSSFGR--SSDKIEIDENTTLKDL--DLNY-----SFFLE 604
VM N+F L IH +DLKGS++GR + DK + ++ + + + DLN+
Sbjct: 552 LVMNNLFPPHLDIHITYDLKGSTWGRFTNLDKERLAKDRSYRPVMKDLNWLEEGQKIKFG 611
Query: 605 PSWRDSLLNQIKIDSKFLEAQHIMDYSLLLGVHYRAPQHVRPLMSYNQRSISTDGLAVLA 664
P + + L Q+K D + L + MDYSLL+G+H + D L LA
Sbjct: 612 PLKKKTFLTQLKKDVELLAKLNTMDYSLLIGIH-------------DINKAKEDDLQ-LA 657
Query: 665 EEDPLEDEVFNYPQGLVLVPRGAGDNSVVVGSHMR--GGRLRASSAGDEVVDLLLPGTAR 722
+ +E++ PQ + G G VV R G +RAS + VDL
Sbjct: 658 DTASIEEQ----PQTQGPIRTGTG---TVVRHFFREFEGGIRASDQFNNDVDL------- 703
Query: 723 LQIQLGVNMPSRAEQNQIIGKQEKQMFHEVNDVVLYLGIIDILQDYNMTKKLEHAYKSLQ 782
+ Y+GIID L +Y++ KKLE ++SL+
Sbjct: 704 ---------------------------------IYYVGIIDFLTNYSVMKKLETFWRSLR 730
Query: 783 FDSVSISVVDPAFYSRRFLEFIQKVFPP 810
D+ +S + P Y+ RF EFI+ P
Sbjct: 731 HDTKLVSAIPPRDYANRFYEFIEDSVDP 758
>PI5B_MOUSE (Q80XI4) Phosphatidylinositol-4-phosphate 5-kinase type
II beta (EC 2.7.1.68)
Length = 416
Score = 141 bits (356), Expect = 6e-33
Identities = 130/436 (29%), Positives = 207/436 (46%), Gaps = 67/436 (15%)
Query: 385 IKGHRSYDLMLS-LQLGIRYTVGKITPVPRREV-RASDFGSKASFWMN---FPREGSPLT 439
+K R+ + +LS L G+ +T+ +++ VP + DF + + ++ F +E P
Sbjct: 33 VKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLP-- 90
Query: 440 PSHQSEDFKWKDYCPMVFRNLRELFKIDAADYMISICGNDALRELSSPGKSGSVFFLSQD 499
FK+K+YCPMVFRNLRE F ID DY S+ + + S G+ G+ F + D
Sbjct: 91 -----SRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINS-DSQGRCGTRFLTTYD 144
Query: 500 DRFMIKTLRKSELKIFLRMLPDYHHH-VKSYENTLITKFFGLHRIKPSSGQKFRFAVMGN 558
RF+IKT+ ++ +L YH V+ + NTL+ +F G++R+ G + V N
Sbjct: 145 RRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRL-TVDGVETYMVVTRN 203
Query: 559 MFCTELRIHRRFDLKGSSFGR-SSDKIEIDENTTLKDLDL---NYSFFLEPSWRDSLLNQ 614
+F L +HR++DLKGS+ R +SDK + + T KD D + + + L +
Sbjct: 204 VFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEK 263
Query: 615 IKIDSKFLEAQHIMDYSLLLGVH--YRAPQHVRPLMSYNQRSISTDGLAVLAEEDPLEDE 672
+K D +FL IMDYSLL+G+H RA Q M +R AEE+ E++
Sbjct: 264 LKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEE---MEVEER----------AEEEECEND 310
Query: 673 VFNYPQGLVLVPRGAGDNSVVVGSHMRGGRLRASSAGDEVVDLLLPGTARLQIQLGVNMP 732
G +L G +S G+ + R D VD+
Sbjct: 311 GVG---GSLLCSYGTPPDS--PGNLLSFPRFFGPGEFDPSVDVY---------------- 349
Query: 733 SRAEQNQIIGKQEKQMFHEVNDVVLYLGIIDILQDYNMTKKLEHAYKSLQFDS-VSISVV 791
+ ++ K+E V ++ IIDIL Y+ KK HA K+++ + IS V
Sbjct: 350 -AMKSHESAPKKE----------VYFMAIIDILTPYDAKKKAAHAAKTVKHGAGAEISTV 398
Query: 792 DPAFYSRRFLEFIQKV 807
+P YS+RF EF+ +
Sbjct: 399 NPEQYSKRFNEFMSNI 414
>PI52_HUMAN (P48426) Phosphatidylinositol-4-phosphate 5-kinase type
II alpha (EC 2.7.1.149) (PIP5KII-alpha)
(1-phosphatidylinositol-4-phosphate 5-kinase)
(PtdIns(4)P-5-kinase B isoform) (Diphosphoinositide
kinase)
Length = 406
Score = 141 bits (355), Expect = 8e-33
Identities = 129/433 (29%), Positives = 205/433 (46%), Gaps = 72/433 (16%)
Query: 385 IKGHRSYDLMLS-LQLGIRYTVGKITPVPRREV-RASDFGSKASFWMNFPREGSPLTPSH 442
+K R+ D +LS L G+ +++ +++ V + DF + + ++ PSH
Sbjct: 28 VKLFRASDPLLSVLMWGVNHSINELSHVQIPVMLMPDDFKAYSKIKVDNHLFNKENMPSH 87
Query: 443 QSEDFKWKDYCPMVFRNLRELFKIDAADYMISICGNDALRELSSPGKSGSVFFLSQDDRF 502
FK+K+YCPMVFRNLRE F ID D+ S+ + L S +SG+ F S D R+
Sbjct: 88 ----FKFKEYCPMVFRNLRERFGIDDQDFQNSLTRSAPLPN-DSQARSGARFHTSYDKRY 142
Query: 503 MIKTLRKSELKIFLRMLPDYHHH-VKSYENTLITKFFGLHRIKPSSGQKFRFAVMGNMFC 561
+IKT+ ++ +L YH + V+ + TL+ +F G++R+ G + V N+F
Sbjct: 143 IIKTITSEDVAEMHNILKKYHQYIVECHGITLLPQFLGMYRLN-VDGVEIYVIVTRNVFS 201
Query: 562 TELRIHRRFDLKGSSFGR-SSDKIEIDENTTLKDLDL---NYSFFLEPSWRDSLLNQIKI 617
L ++R++DLKGS+ R +SDK + E TLKD D +++ + + L ++K
Sbjct: 202 HRLSVYRKYDLKGSTVAREASDKEKAKELPTLKDNDFINEGQKIYIDDNNKKVFLEKLKK 261
Query: 618 DSKFLEAQHIMDYSLLLGVH--YRAPQHVRPLMSYNQRSISTDGLAVLAEEDPLEDEVFN 675
D +FL +MDYSLL+G+H RA Q V EE+ E+E
Sbjct: 262 DVEFLAQLKLMDYSLLVGIHDVERAEQE-----------------EVECEENDGEEE--- 301
Query: 676 YPQGLVLVPRGAGDNSVVVGS--HMRGGRLRASSAGDEVVDLLLPGTARLQIQL-GVNMP 732
G D + VG+ G L +S L PG I + G+
Sbjct: 302 ----------GESDGTHPVGTPPDSPGNTLNSSPP-------LAPGEFDPNIDVYGIKCH 344
Query: 733 SRAEQNQIIGKQEKQMFHEVNDVVLYLGIIDILQDYNMTKKLEHAYKSLQFDS-VSISVV 791
+ + + V ++ IIDIL Y+ KK HA K+++ + IS V
Sbjct: 345 ENSPRKE----------------VYFMAIIDILTHYDAKKKAAHAAKTVKHGAGAEISTV 388
Query: 792 DPAFYSRRFLEFI 804
+P YS+RFL+FI
Sbjct: 389 NPEQYSKRFLDFI 401
>PI52_MOUSE (O70172) Phosphatidylinositol-4-phosphate 5-kinase type
II alpha (EC 2.7.1.149) (PIP5KII-alpha)
(1-phosphatidylinositol-4-phosphate 5-kinase)
(PtdIns(4)P-5-kinase B isoform) (Diphosphoinositide
kinase)
Length = 405
Score = 140 bits (352), Expect = 2e-32
Identities = 128/433 (29%), Positives = 205/433 (46%), Gaps = 72/433 (16%)
Query: 385 IKGHRSYDLMLS-LQLGIRYTVGKITPVPRREV-RASDFGSKASFWMNFPREGSPLTPSH 442
+K R+ D +LS L G+ +++ +++ V + DF + + ++ PSH
Sbjct: 28 VKLFRASDPLLSVLMWGVNHSINELSHVQIPVMLMPDDFKAYSKIKVDNHLFNKENMPSH 87
Query: 443 QSEDFKWKDYCPMVFRNLRELFKIDAADYMISICGNDALRELSSPGKSGSVFFLSQDDRF 502
FK+K+YCPMVFRNLRE F ID D+ S+ + L S +SG+ F S D R+
Sbjct: 88 ----FKFKEYCPMVFRNLRERFGIDDQDFQNSLTRSAPLPN-DSQARSGARFHTSYDKRY 142
Query: 503 MIKTLRKSELKIFLRMLPDYHHH-VKSYENTLITKFFGLHRIKPSSGQKFRFAVMGNMFC 561
+IKT+ ++ +L YH + V+ + TL+ +F G++R+ G + V N+F
Sbjct: 143 VIKTITSEDVAEMHNILKKYHQYIVECHGVTLLPQFLGMYRLN-VDGVEIYVIVTRNVFS 201
Query: 562 TELRIHRRFDLKGSSFGR-SSDKIEIDENTTLKDLDL---NYSFFLEPSWRDSLLNQIKI 617
L ++R++DLKGS+ R +SDK + E TLKD D +++ + + L ++K
Sbjct: 202 HRLSVYRKYDLKGSTVAREASDKEKAKELPTLKDNDFINEGQKIYIDDNNKKIFLEKLKK 261
Query: 618 DSKFLEAQHIMDYSLLLGVH--YRAPQHVRPLMSYNQRSISTDGLAVLAEEDPLEDEVFN 675
D +FL +MDYSLL+G+H RA Q V EE+ E+E
Sbjct: 262 DVEFLAQLKLMDYSLLVGIHDVERAEQE-----------------EVECEENDGEEE--- 301
Query: 676 YPQGLVLVPRGAGDNSVVVGS--HMRGGRLRASSAGDEVVDLLLPGTARLQIQL-GVNMP 732
G D++ +G+ G L +S L PG I + +
Sbjct: 302 ----------GESDSTHPIGTPPDSPGNTLNSSPP-------LAPGEFDPNIDVYAIKCH 344
Query: 733 SRAEQNQIIGKQEKQMFHEVNDVVLYLGIIDILQDYNMTKKLEHAYKSLQFDS-VSISVV 791
A + + V ++ IIDIL Y+ KK HA K+++ + IS V
Sbjct: 345 ENAPRKE----------------VYFMAIIDILTHYDAKKKAAHAAKTVKHGAGAEISTV 388
Query: 792 DPAFYSRRFLEFI 804
+P YS+RFL+FI
Sbjct: 389 NPEQYSKRFLDFI 401
>PI5B_HUMAN (P78356) Phosphatidylinositol-4-phosphate 5-kinase type
II beta (EC 2.7.1.68) (PIP5KIIbeta)
Length = 416
Score = 139 bits (351), Expect = 2e-32
Identities = 129/436 (29%), Positives = 207/436 (46%), Gaps = 67/436 (15%)
Query: 385 IKGHRSYDLMLS-LQLGIRYTVGKITPVPRREV-RASDFGSKASFWMN---FPREGSPLT 439
+K R+ + +LS L G+ +T+ +++ VP + DF + + ++ F +E P
Sbjct: 33 VKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLP-- 90
Query: 440 PSHQSEDFKWKDYCPMVFRNLRELFKIDAADYMISICGNDALRELSSPGKSGSVFFLSQD 499
FK+K+YCPMVFRNLRE F ID DY S+ + + S G+ G+ F + D
Sbjct: 91 -----SRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINS-DSQGRCGTRFLTTYD 144
Query: 500 DRFMIKTLRKSELKIFLRMLPDYHHH-VKSYENTLITKFFGLHRIKPSSGQKFRFAVMGN 558
RF+IKT+ ++ +L YH V+ + NTL+ +F G++R+ G + V N
Sbjct: 145 RRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRL-TVDGVETYMVVTRN 203
Query: 559 MFCTELRIHRRFDLKGSSFGR-SSDKIEIDENTTLKDLDL---NYSFFLEPSWRDSLLNQ 614
+F L +HR++DLKGS+ R +SDK + + T KD D + + + L +
Sbjct: 204 VFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEK 263
Query: 615 IKIDSKFLEAQHIMDYSLLLGVH--YRAPQHVRPLMSYNQRSISTDGLAVLAEEDPLEDE 672
+K D +FL IMDYSLL+G+H RA Q M +R AE++ E++
Sbjct: 264 LKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEE---MEVEER----------AEDEECEND 310
Query: 673 VFNYPQGLVLVPRGAGDNSVVVGSHMRGGRLRASSAGDEVVDLLLPGTARLQIQLGVNMP 732
G +L G +S G+ + R D VD+
Sbjct: 311 GVG---GNLLCSYGTPPDS--PGNLLSFPRFFGPGEFDPSVDVY---------------- 349
Query: 733 SRAEQNQIIGKQEKQMFHEVNDVVLYLGIIDILQDYNMTKKLEHAYKSLQFDS-VSISVV 791
+ ++ K+E V ++ IIDIL Y+ KK HA K+++ + IS V
Sbjct: 350 -AMKSHESSPKKE----------VYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTV 398
Query: 792 DPAFYSRRFLEFIQKV 807
+P YS+RF EF+ +
Sbjct: 399 NPEQYSKRFNEFMSNI 414
>PI53_HUMAN (P53807) Phosphatidylinositol-4-phosphate 5-kinase type
III (EC 2.7.1.149) (1-phosphatidylinositol-4-phosphate
kinase) (PIP5KIII) (PtdIns(4)P-5-kinase C isoform)
(Diphosphoinositide kinase)
Length = 406
Score = 135 bits (340), Expect = 4e-31
Identities = 126/433 (29%), Positives = 201/433 (46%), Gaps = 72/433 (16%)
Query: 385 IKGHRSYDLMLS-LQLGIRYTVGKITPVPRREV-RASDFGSKASFWMNFPREGSPLTPSH 442
+K R+ D +LS L G+ +++ +++ V + DF + + ++ PSH
Sbjct: 28 VKLFRASDPLLSVLMWGVNHSINELSHVQIPVMLMPDDFKAYSKIKVDNHLFNKENMPSH 87
Query: 443 QSEDFKWKDYCPMVFRNLRELFKIDAADYMISICGNDALRELSSPGKSGSVFFLSQDDRF 502
FK+K+YCPMVFRN + F ID D+ S+ + L S +SG+ F S D R+
Sbjct: 88 ----FKFKEYCPMVFRNCGKRFGIDVQDFQNSLTRSAPLPN-DSQARSGARFHTSYDKRY 142
Query: 503 MIKTLRKSELKIFLRMLPDYHHH-VKSYENTLITKFFGLHRIKPSSGQKFRFAVMGNMFC 561
MIKT+ ++ +L YH + V+ + TL+ G++R+ G + V N+F
Sbjct: 143 MIKTITSEDVAEMHNILKKYHQYIVECHGITLLPHLLGMYRLN-VDGVEIYVIVTRNVFS 201
Query: 562 TELRIHRRFDLKGSSFGR-SSDKIEIDENTTLKDLDL---NYSFFLEPSWRDSLLNQIKI 617
L ++R++DLKGS+ R +SDK + E TLKD D +++ + + L ++K
Sbjct: 202 HRLSVYRKYDLKGSTVAREASDKEKAKELPTLKDNDFINEGQKIYIDDNSKKVFLEKLKK 261
Query: 618 DSKFLEAQHIMDYSLLLGVH--YRAPQHVRPLMSYNQRSISTDGLAVLAEEDPLEDEVFN 675
D +FL +MDYSLL+G+H RA Q V EE+ E+E
Sbjct: 262 DVEFLAQLKLMDYSLLVGIHDVERAEQE-----------------EVECEENDGEEE--- 301
Query: 676 YPQGLVLVPRGAGDNSVVVGS--HMRGGRLRASSAGDEVVDLLLPGTARLQIQL-GVNMP 732
G D + VG+ G L +S L PG I + G+
Sbjct: 302 ----------GESDGTHPVGTPPDSPGNTLNSSPP-------LAPGEFEPNIDVYGIKCH 344
Query: 733 SRAEQNQIIGKQEKQMFHEVNDVVLYLGIIDILQDYNMTKKLEHAYKSLQFDS-VSISVV 791
+ + + V ++ IIDIL Y+ KK HA K+++ + IS V
Sbjct: 345 ENSPRKE----------------VYFMAIIDILTHYDAKKKAAHAAKTVKHGAGAEISTV 388
Query: 792 DPAFYSRRFLEFI 804
+P YS+RFL+FI
Sbjct: 389 NPEQYSKRFLDFI 401
>PI5B_RAT (O88377) Phosphatidylinositol-4-phosphate 5-kinase type II
beta (EC 2.7.1.68) (Phosphatidylinositol-phosphate
kinase IIgamma) (PIPKIIgamma)
Length = 416
Score = 129 bits (323), Expect = 4e-29
Identities = 121/434 (27%), Positives = 201/434 (45%), Gaps = 63/434 (14%)
Query: 385 IKGHRSYDLMLS-LQLGIRYTVGKITPVPRREV-RASDFGSKASFWMN---FPREGSPLT 439
+K R+ + +LS L G+ +T+ +++ VP + DF + + ++ F +E P
Sbjct: 33 VKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLP-- 90
Query: 440 PSHQSEDFKWKDYCPMVFRNLRELFKIDAADYMISICGNDALRELSSPGKSGSVFFLSQD 499
FK+K+YCPMVFRNLRE F ID DY S+ + + S G+ G+ F + D
Sbjct: 91 -----SRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINS-DSQGRCGTRFLTTYD 144
Query: 500 DRFMIKTLRKSELKIFLRMLPDYHHH-VKSYENTLITKFFGLHRIKPSSGQKFRFAVMGN 558
RF+IKT+ ++ +L YH V+ + NTL+ +F G++R+ G + V N
Sbjct: 145 RRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRL-TVDGVETYMVVTRN 203
Query: 559 MFCTELRIHRRFDLKGSSFGR-SSDKIEIDENTTLKDLDL---NYSFFLEPSWRDSLLNQ 614
+F L +HR++DLKGS+ R +SDK + + T KD D + + + L +
Sbjct: 204 VFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLRVGEESKKNFLEK 263
Query: 615 IKIDSKFLEAQHIMDYSLLLGVHYRAPQHVRPLMSYNQRSISTDGLAVLAEEDPLEDEVF 674
+K D +FL IMDYSLL+G+H ++ + AEE+ E++
Sbjct: 264 LKRDVEFLAQLKIMDYSLLVGIH-----------DVDRAEQEETEVEDRAEEEECENDGV 312
Query: 675 NYPQGLVLVPRGAGDNSVVVGSHMRGGRLRASSAGDEVVDLLLPGTARLQIQLGVNMPSR 734
G +L G +S G+ + R D VD+
Sbjct: 313 G---GGLLCSYGTPPDS--PGNLLSFPRFFGPGEFDPSVDVY------------------ 349
Query: 735 AEQNQIIGKQEKQMFHEVNDVVLYLGIIDILQDYNMTKKLEHAYKSLQFDS-VSISVVDP 793
A ++ +++ F + D+ L Y+ KK HA K+++ + IS V+P
Sbjct: 350 AMKSHESAPKKEVYFMAIIDI---------LTPYDAKKKAAHAAKTVKHGAGAEISTVNP 400
Query: 794 AFYSRRFLEFIQKV 807
YS+RF EF+ +
Sbjct: 401 EQYSKRFNEFMSNI 414
>TSA2_MOUSE (Q8VIG3) Testis-specific gene A2 (Male meiotic metaphase
chromosome-associated acidic protein) (Meichroacidin)
Length = 301
Score = 90.1 bits (222), Expect = 2e-17
Identities = 53/152 (34%), Positives = 66/152 (42%), Gaps = 25/152 (16%)
Query: 77 YEGGWRR-GMRHGNGKIRWPYGAVYEGEFSGGYIQGTGKYIGSDHLTYKGRWRLNLKHGL 135
YEG G RHG+GK R P G YEG + G G G Y + Y G + N KHG
Sbjct: 20 YEGERNEVGERHGHGKARLPNGDTYEGSYEFGKRHGQGTYKFKNGARYTGDYVKNKKHGQ 79
Query: 136 GYQVYPNGDILEGSWIQGTPEGPGKYTWTNGNVYVGNMKGGTMSGKGTLTWINGDSYEGS 195
G +YP+G EG W G G Y + +N D+Y G
Sbjct: 80 GTFIYPDGSRYEGEWADDQRHGQGVYYY-----------------------VNNDTYTGE 116
Query: 196 WLNGMMHGFGAYTWS-GGGCYVGTWTCGLKDG 226
W N HG G Y ++ G YVGTW G ++G
Sbjct: 117 WFNHQRHGQGTYLYAETGSKYVGTWVHGQQEG 148
Score = 83.6 bits (205), Expect = 2e-15
Identities = 55/174 (31%), Positives = 73/174 (41%), Gaps = 7/174 (4%)
Query: 45 ELLLSNGESYSGTLFGNTPE-----GHGTYVWSDRCVYEGGWRRGMRHGNGKIRWPYGAV 99
E L GE+ G G E GHG + YEG + G RHG G ++ GA
Sbjct: 7 EELEEEGENDLGEYEGERNEVGERHGHGKARLPNGDTYEGSYEFGKRHGQGTYKFKNGAR 66
Query: 100 YEGEFSGGYIQGTGKYIGSDHLTYKGRWRLNLKHGLGYQVYPNGDILEGSWIQGTPEGPG 159
Y G++ G G +I D Y+G W + +HG G Y N D G W G G
Sbjct: 67 YTGDYVKNKKHGQGTFIYPDGSRYEGEWADDQRHGQGVYYYVNNDTYTGEWFNHQRHGQG 126
Query: 160 KYTWT-NGNVYVGNMKGGTMSGKGTLTWINGDSYEGSWLNGMMHGFGAYTWSGG 212
Y + G+ YVG G G L +N Y+G ++N G G Y + G
Sbjct: 127 TYLYAETGSKYVGTWVHGQQEGAAELIHLN-HRYQGKFMNKNPVGPGKYVFDIG 179
Score = 75.9 bits (185), Expect = 4e-13
Identities = 45/154 (29%), Positives = 69/154 (44%), Gaps = 2/154 (1%)
Query: 44 GELLLSNGESYSGTLFGNTPEGHGTYVWSDRCVYEGGWRRGMRHGNGKIRWPYGAVYEGE 103
G+ L NG++Y G+ G GTY + + Y G + + +HG G +P G+ YEGE
Sbjct: 34 GKARLPNGDTYEGSYEFGKRHGQGTYKFKNGARYTGDYVKNKKHGQGTFIYPDGSRYEGE 93
Query: 104 FSGGYIQGTGKYIGSDHLTYKGRWRLNLKHGLGYQVY-PNGDILEGSWIQGTPEGPGKYT 162
++ G G Y ++ TY G W + +HG G +Y G G+W+ G EG +
Sbjct: 94 WADDQRHGQGVYYYVNNDTYTGEWFNHQRHGQGTYLYAETGSKYVGTWVHGQQEGAAELI 153
Query: 163 WTNGNVYVGNMKGGTMSGKGTLTWINGDSYEGSW 196
N + Y G G G + G G +
Sbjct: 154 HLN-HRYQGKFMNKNPVGPGKYVFDIGCEQHGEY 186
Score = 75.5 bits (184), Expect = 5e-13
Identities = 39/109 (35%), Positives = 53/109 (47%), Gaps = 1/109 (0%)
Query: 123 YKG-RWRLNLKHGLGYQVYPNGDILEGSWIQGTPEGPGKYTWTNGNVYVGNMKGGTMSGK 181
Y+G R + +HG G PNGD EGS+ G G G Y + NG Y G+ G+
Sbjct: 20 YEGERNEVGERHGHGKARLPNGDTYEGSYEFGKRHGQGTYKFKNGARYTGDYVKNKKHGQ 79
Query: 182 GTLTWINGDSYEGSWLNGMMHGFGAYTWSGGGCYVGTWTCGLKDGKGTF 230
GT + +G YEG W + HG G Y + Y G W + G+GT+
Sbjct: 80 GTFIYPDGSRYEGEWADDQRHGQGVYYYVNNDTYTGEWFNHQRHGQGTY 128
Score = 56.2 bits (134), Expect = 3e-07
Identities = 26/79 (32%), Positives = 38/79 (47%)
Query: 153 GTPEGPGKYTWTNGNVYVGNMKGGTMSGKGTLTWINGDSYEGSWLNGMMHGFGAYTWSGG 212
G G GK NG+ Y G+ + G G+GT + NG Y G ++ HG G + + G
Sbjct: 28 GERHGHGKARLPNGDTYEGSYEFGKRHGQGTYKFKNGARYTGDYVKNKKHGQGTFIYPDG 87
Query: 213 GCYVGTWTCGLKDGKGTFY 231
Y G W + G+G +Y
Sbjct: 88 SRYEGEWADDQRHGQGVYY 106
Score = 38.9 bits (89), Expect = 0.055
Identities = 23/81 (28%), Positives = 38/81 (46%), Gaps = 2/81 (2%)
Query: 50 NGESYSGTLFGNTPEGHGTYVWSDR-CVYEGGWRRGMRHGNGKIRWPYGAVYEGEFSGGY 108
N ++Y+G F + G GTY++++ Y G W G + G ++ Y+G+F
Sbjct: 109 NNDTYTGEWFNHQRHGQGTYLYAETGSKYVGTWVHGQQEGAAELIH-LNHRYQGKFMNKN 167
Query: 109 IQGTGKYIGSDHLTYKGRWRL 129
G GKY+ G +RL
Sbjct: 168 PVGPGKYVFDIGCEQHGEYRL 188
>TSA2_HUMAN (Q8WYR4) Testis-specific gene A2 (Male meiotic metaphase
chromosome-associated acidic protein) (Meichroacidin)
Length = 309
Score = 89.4 bits (220), Expect = 4e-17
Identities = 48/129 (37%), Positives = 60/129 (46%), Gaps = 2/129 (1%)
Query: 77 YEGGWRR-GMRHGNGKIRWPYGAVYEGEFSGGYIQGTGKYIGSDHLTYKGRWRLNLKHGL 135
YEGG G RHG G+ R P G YEG + G G G Y + Y G + N KHG
Sbjct: 20 YEGGRNEAGERHGRGRARLPNGDTYEGSYEFGKRHGQGIYKFKNGARYIGEYVRNKKHGQ 79
Query: 136 GYQVYPNGDILEGSWIQGTPEGPGKYTWTNGNVYVGNMKGGTMSGKGTLTWI-NGDSYEG 194
G +YP+G EG W G G Y + N + Y G G+GT + G Y G
Sbjct: 80 GTFIYPDGSRYEGEWANDLRHGHGVYYYINNDTYTGEWFAHQRHGQGTYLYAETGSKYVG 139
Query: 195 SWLNGMMHG 203
+W+NG G
Sbjct: 140 TWVNGQQEG 148
Score = 83.6 bits (205), Expect = 2e-15
Identities = 53/163 (32%), Positives = 68/163 (41%), Gaps = 2/163 (1%)
Query: 51 GESYSGTLFGNTPEGHGTYVWSDRCVYEGGWRRGMRHGNGKIRWPYGAVYEGEFSGGYIQ 110
GE G G G + YEG + G RHG G ++ GA Y GE+
Sbjct: 18 GEYEGGRNEAGERHGRGRARLPNGDTYEGSYEFGKRHGQGIYKFKNGARYIGEYVRNKKH 77
Query: 111 GTGKYIGSDHLTYKGRWRLNLKHGLGYQVYPNGDILEGSWIQGTPEGPGKYTWT-NGNVY 169
G G +I D Y+G W +L+HG G Y N D G W G G Y + G+ Y
Sbjct: 78 GQGTFIYPDGSRYEGEWANDLRHGHGVYYYINNDTYTGEWFAHQRHGQGTYLYAETGSKY 137
Query: 170 VGNMKGGTMSGKGTLTWINGDSYEGSWLNGMMHGFGAYTWSGG 212
VG G G L +N Y+G +LN G G Y + G
Sbjct: 138 VGTWVNGQQEGTAELIHLN-HRYQGKFLNKNPVGPGKYVFDVG 179
Score = 81.3 bits (199), Expect = 1e-14
Identities = 39/106 (36%), Positives = 51/106 (47%)
Query: 125 GRWRLNLKHGLGYQVYPNGDILEGSWIQGTPEGPGKYTWTNGNVYVGNMKGGTMSGKGTL 184
GR +HG G PNGD EGS+ G G G Y + NG Y+G G+GT
Sbjct: 23 GRNEAGERHGRGRARLPNGDTYEGSYEFGKRHGQGIYKFKNGARYIGEYVRNKKHGQGTF 82
Query: 185 TWINGDSYEGSWLNGMMHGFGAYTWSGGGCYVGTWTCGLKDGKGTF 230
+ +G YEG W N + HG G Y + Y G W + G+GT+
Sbjct: 83 IYPDGSRYEGEWANDLRHGHGVYYYINNDTYTGEWFAHQRHGQGTY 128
Score = 53.5 bits (127), Expect = 2e-06
Identities = 25/79 (31%), Positives = 37/79 (46%)
Query: 153 GTPEGPGKYTWTNGNVYVGNMKGGTMSGKGTLTWINGDSYEGSWLNGMMHGFGAYTWSGG 212
G G G+ NG+ Y G+ + G G+G + NG Y G ++ HG G + + G
Sbjct: 28 GERHGRGRARLPNGDTYEGSYEFGKRHGQGIYKFKNGARYIGEYVRNKKHGQGTFIYPDG 87
Query: 213 GCYVGTWTCGLKDGKGTFY 231
Y G W L+ G G +Y
Sbjct: 88 SRYEGEWANDLRHGHGVYY 106
Score = 39.3 bits (90), Expect = 0.042
Identities = 23/81 (28%), Positives = 38/81 (46%), Gaps = 2/81 (2%)
Query: 50 NGESYSGTLFGNTPEGHGTYVWSDR-CVYEGGWRRGMRHGNGKIRWPYGAVYEGEFSGGY 108
N ++Y+G F + G GTY++++ Y G W G + G ++ Y+G+F
Sbjct: 109 NNDTYTGEWFAHQRHGQGTYLYAETGSKYVGTWVNGQQEGTAELIH-LNHRYQGKFLNKN 167
Query: 109 IQGTGKYIGSDHLTYKGRWRL 129
G GKY+ G +RL
Sbjct: 168 PVGPGKYVFDVGCEQHGEYRL 188
>JPH3_MOUSE (Q9ET77) Junctophilin 3 (Junctophilin type 3) (JP-3)
Length = 744
Score = 85.1 bits (209), Expect = 7e-16
Identities = 57/190 (30%), Positives = 83/190 (43%), Gaps = 33/190 (17%)
Query: 67 GTYVWSDRCVYEGGWRRGMRHGNGKIRWPYGAVYEGEFSGGYIQG---TGKYIGSDHLTY 123
G + + D Y GGW G HG+G P G +GE++G + G G Y TY
Sbjct: 5 GRFNFDDGGSYCGGWEDGKAHGHGVCTGPKG---QGEYTGSWSHGFEVLGVYTWPSGNTY 61
Query: 124 KGRWRLNLKHGLGYQVYPNGDILEGSWIQGTPEGPGKYTWTNGNVYVGNMKGGTMSGKGT 183
+G W +HG+G + +G W+ K WT+G + G +G G
Sbjct: 62 QGTWAQGKRHGIGLE-------SKGKWVY-------KGEWTHG--FKGRYGVRECTGNGA 105
Query: 184 LTWINGDSYEGSWLNGMMHGFGAYTWSGGGCYVGTWTCGLKDGKGTF----YPKGSHLTS 239
YEG+W NG+ G+G T+S GG Y G W G++ G G Y + + S
Sbjct: 106 -------KYEGTWSNGLQDGYGTETYSDGGTYQGQWVGGMRQGYGVRQSVPYGMAAVIRS 158
Query: 240 AQEIYLNALR 249
+N+LR
Sbjct: 159 PLRTSINSLR 168
Score = 42.0 bits (97), Expect = 0.007
Identities = 21/49 (42%), Positives = 26/49 (52%), Gaps = 1/49 (2%)
Query: 50 NGESYSGTLFGNTPEGHGTYVWSDRCVYEGGWRRGMRHGNG-KIRWPYG 97
NG Y GT +G+GT +SD Y+G W GMR G G + PYG
Sbjct: 103 NGAKYEGTWSNGLQDGYGTETYSDGGTYQGQWVGGMRQGYGVRQSVPYG 151
Score = 40.4 bits (93), Expect = 0.019
Identities = 23/74 (31%), Positives = 27/74 (36%), Gaps = 23/74 (31%)
Query: 178 MSGKGTLTWINGDSYEGSWLNGMMHG-----------------------FGAYTWSGGGC 214
MS G + +G SY G W +G HG G YTW G
Sbjct: 1 MSSGGRFNFDDGGSYCGGWEDGKAHGHGVCTGPKGQGEYTGSWSHGFEVLGVYTWPSGNT 60
Query: 215 YVGTWTCGLKDGKG 228
Y GTW G + G G
Sbjct: 61 YQGTWAQGKRHGIG 74
Score = 39.7 bits (91), Expect = 0.032
Identities = 20/53 (37%), Positives = 26/53 (48%)
Query: 100 YEGEFSGGYIQGTGKYIGSDHLTYKGRWRLNLKHGLGYQVYPNGDILEGSWIQ 152
Y GE+ G G SD L Y+G W N +HG G +P+G EG + Q
Sbjct: 288 YVGEWKNDKRSGFGVSQRSDGLKYEGEWVSNRRHGYGCMTFPDGTKEEGKYKQ 340
Score = 39.3 bits (90), Expect = 0.042
Identities = 18/49 (36%), Positives = 23/49 (46%)
Query: 164 TNGNVYVGNMKGGTMSGKGTLTWINGDSYEGSWLNGMMHGFGAYTWSGG 212
T YVG K SG G +G YEG W++ HG+G T+ G
Sbjct: 283 TTTETYVGEWKNDKRSGFGVSQRSDGLKYEGEWVSNRRHGYGCMTFPDG 331
Score = 37.0 bits (84), Expect = 0.21
Identities = 25/88 (28%), Positives = 39/88 (43%), Gaps = 3/88 (3%)
Query: 17 SSEINNNLSLVTIGEAGHSSEIDSFSVGELLLSNGESYSGTLFGNTPEGHGTYVWSDRCV 76
SS ++ S +++GEA + + + E+Y G + G G SD
Sbjct: 254 SSTASDIHSTISLGEAEAELAVIEDDIDA---TTTETYVGEWKNDKRSGFGVSQRSDGLK 310
Query: 77 YEGGWRRGMRHGNGKIRWPYGAVYEGEF 104
YEG W RHG G + +P G EG++
Sbjct: 311 YEGEWVSNRRHGYGCMTFPDGTKEEGKY 338
Score = 34.3 bits (77), Expect = 1.4
Identities = 19/61 (31%), Positives = 27/61 (44%), Gaps = 1/61 (1%)
Query: 122 TYKGRWRLNLKHGLGYQVYPNGDILEGSWIQGTPEGPGKYTWTNGNVYVGNMKGGTM-SG 180
TY G W+ + + G G +G EG W+ G G T+ +G G K + SG
Sbjct: 287 TYVGEWKNDKRSGFGVSQRSDGLKYEGEWVSNRRHGYGCMTFPDGTKEEGKYKQNVLVSG 346
Query: 181 K 181
K
Sbjct: 347 K 347
Score = 32.3 bits (72), Expect = 5.2
Identities = 25/84 (29%), Positives = 37/84 (43%), Gaps = 11/84 (13%)
Query: 190 DSYEGSWLNGMMHGFGAYTWSGGGCYVGTWTCGLKDGKGTF-YPKGSHLTSAQEIYLNAL 248
++Y G W N GFG S G Y G W + G G +P G T + Y
Sbjct: 286 ETYVGEWKNDKRSGFGVSQRSDGLKYEGEWVSNRRHGYGCMTFPDG---TKEEGKY---- 338
Query: 249 RKRGLLPDLRKQNLV--RGVKVGE 270
K+ +L +++NL+ R K+ E
Sbjct: 339 -KQNVLVSGKRKNLIPLRASKIRE 361
>JPH3_HUMAN (Q8WXH2) Junctophilin 3 (Junctophilin type 3) (JP-3)
Length = 748
Score = 85.1 bits (209), Expect = 7e-16
Identities = 57/190 (30%), Positives = 83/190 (43%), Gaps = 33/190 (17%)
Query: 67 GTYVWSDRCVYEGGWRRGMRHGNGKIRWPYGAVYEGEFSGGYIQG---TGKYIGSDHLTY 123
G + + D Y GGW G HG+G P G +GE++G + G G Y TY
Sbjct: 5 GRFNFDDGGSYCGGWEDGKAHGHGVCTGPKG---QGEYTGSWSHGFEVLGVYTWPSGNTY 61
Query: 124 KGRWRLNLKHGLGYQVYPNGDILEGSWIQGTPEGPGKYTWTNGNVYVGNMKGGTMSGKGT 183
+G W +HG+G + +G W+ K WT+G + G +G G
Sbjct: 62 QGTWAQGKRHGIGLE-------SKGKWVY-------KGEWTHG--FKGRYGVRECAGNGA 105
Query: 184 LTWINGDSYEGSWLNGMMHGFGAYTWSGGGCYVGTWTCGLKDGKGTF----YPKGSHLTS 239
YEG+W NG+ G+G T+S GG Y G W G++ G G Y + + S
Sbjct: 106 -------KYEGTWSNGLQDGYGTETYSDGGTYQGQWVGGMRQGYGVRQSVPYGMAAVIRS 158
Query: 240 AQEIYLNALR 249
+N+LR
Sbjct: 159 PLRTSINSLR 168
Score = 42.0 bits (97), Expect = 0.007
Identities = 21/49 (42%), Positives = 26/49 (52%), Gaps = 1/49 (2%)
Query: 50 NGESYSGTLFGNTPEGHGTYVWSDRCVYEGGWRRGMRHGNG-KIRWPYG 97
NG Y GT +G+GT +SD Y+G W GMR G G + PYG
Sbjct: 103 NGAKYEGTWSNGLQDGYGTETYSDGGTYQGQWVGGMRQGYGVRQSVPYG 151
Score = 40.4 bits (93), Expect = 0.019
Identities = 20/53 (37%), Positives = 26/53 (48%)
Query: 100 YEGEFSGGYIQGTGKYIGSDHLTYKGRWRLNLKHGLGYQVYPNGDILEGSWIQ 152
Y GE+ G G SD L Y+G W N +HG G +P+G EG + Q
Sbjct: 288 YVGEWKNDKRSGFGVSQRSDGLKYEGEWASNRRHGYGCMTFPDGTKEEGKYKQ 340
Score = 40.4 bits (93), Expect = 0.019
Identities = 23/74 (31%), Positives = 27/74 (36%), Gaps = 23/74 (31%)
Query: 178 MSGKGTLTWINGDSYEGSWLNGMMHG-----------------------FGAYTWSGGGC 214
MS G + +G SY G W +G HG G YTW G
Sbjct: 1 MSSGGRFNFDDGGSYCGGWEDGKAHGHGVCTGPKGQGEYTGSWSHGFEVLGVYTWPSGNT 60
Query: 215 YVGTWTCGLKDGKG 228
Y GTW G + G G
Sbjct: 61 YQGTWAQGKRHGIG 74
Score = 38.9 bits (89), Expect = 0.055
Identities = 26/95 (27%), Positives = 41/95 (42%), Gaps = 3/95 (3%)
Query: 17 SSEINNNLSLVTIGEAGHSSEIDSFSVGELLLSNGESYSGTLFGNTPEGHGTYVWSDRCV 76
SS ++ S +++GEA + + + E+Y G + G G SD
Sbjct: 254 SSTASDIHSTISLGEAEAELAVIEDDIDA---TTTETYVGEWKNDKRSGFGVSQRSDGLK 310
Query: 77 YEGGWRRGMRHGNGKIRWPYGAVYEGEFSGGYIQG 111
YEG W RHG G + +P G EG++ + G
Sbjct: 311 YEGEWASNRRHGYGCMTFPDGTKEEGKYKQNILVG 345
Score = 38.5 bits (88), Expect = 0.072
Identities = 18/49 (36%), Positives = 22/49 (44%)
Query: 164 TNGNVYVGNMKGGTMSGKGTLTWINGDSYEGSWLNGMMHGFGAYTWSGG 212
T YVG K SG G +G YEG W + HG+G T+ G
Sbjct: 283 TTTETYVGEWKNDKRSGFGVSQRSDGLKYEGEWASNRRHGYGCMTFPDG 331
Score = 32.7 bits (73), Expect = 4.0
Identities = 17/59 (28%), Positives = 24/59 (39%)
Query: 122 TYKGRWRLNLKHGLGYQVYPNGDILEGSWIQGTPEGPGKYTWTNGNVYVGNMKGGTMSG 180
TY G W+ + + G G +G EG W G G T+ +G G K + G
Sbjct: 287 TYVGEWKNDKRSGFGVSQRSDGLKYEGEWASNRRHGYGCMTFPDGTKEEGKYKQNILVG 345
Score = 32.3 bits (72), Expect = 5.2
Identities = 25/84 (29%), Positives = 37/84 (43%), Gaps = 11/84 (13%)
Query: 190 DSYEGSWLNGMMHGFGAYTWSGGGCYVGTWTCGLKDGKGTF-YPKGSHLTSAQEIYLNAL 248
++Y G W N GFG S G Y G W + G G +P G T + Y
Sbjct: 286 ETYVGEWKNDKRSGFGVSQRSDGLKYEGEWASNRRHGYGCMTFPDG---TKEEGKY---- 338
Query: 249 RKRGLLPDLRKQNLV--RGVKVGE 270
K+ +L +++NL+ R K+ E
Sbjct: 339 -KQNILVGGKRKNLIPLRASKIRE 361
>JPH2_RABIT (Q9GKY7) Junctophilin 2 (Junctophilin type 2) (JP-2)
Length = 694
Score = 81.3 bits (199), Expect = 1e-14
Identities = 53/165 (32%), Positives = 77/165 (46%), Gaps = 29/165 (17%)
Query: 67 GTYVWSDRCVYEGGWRRGMRHGNGKIRWPYGAVYEGEFSGGYIQG---TGKYIGSDHLTY 123
G + + D Y GGW G HG+G P G +GE+SG + G G Y T+
Sbjct: 4 GRFDFDDGGAYCGGWEGGKAHGHGLCTGPKG---QGEYSGSWNFGFEVAGVYTWPSGNTF 60
Query: 124 KGRWRLNLKHGLGYQVYPNGDILEGSWIQGTPEGPGKYTWTNGNVYVGNMKGGTMSGKGT 183
+G W +HGLG + +G W+ K WT+G KG + + T
Sbjct: 61 EGYWSQGKRHGLGIET-------KGRWLY-------KGEWTHG------FKGRYGTRQST 100
Query: 184 LTWINGDSYEGSWLNGMMHGFGAYTWSGGGCYVGTWTCGLKDGKG 228
+G YEG+W NG+ G+G T++ GG Y G +T G++ G G
Sbjct: 101 ---SSGAKYEGTWNNGLQDGYGTETYADGGTYQGQFTNGMRHGYG 142
Score = 64.3 bits (155), Expect = 1e-09
Identities = 44/122 (36%), Positives = 54/122 (44%), Gaps = 10/122 (8%)
Query: 113 GKYIGSDHLTYKGRWRLNLKHGLGYQVYPNGD-ILEGSWIQGTPEGPGKYTWTNGNVYVG 171
G++ D Y G W HG G P G GSW G E G YTW +GN + G
Sbjct: 4 GRFDFDDGGAYCGGWEGGKAHGHGLCTGPKGQGEYSGSWNFGF-EVAGVYTWPSGNTFEG 62
Query: 172 NMKGGTMSGKGTLT---WINGDSYEGSWLNGMMHGFGA-YTWSGGGCYVGTWTCGLKDGK 227
G G G T W+ Y+G W +G +G + S G Y GTW GL+DG
Sbjct: 63 YWSQGKRHGLGIETKGRWL----YKGEWTHGFKGRYGTRQSTSSGAKYEGTWNNGLQDGY 118
Query: 228 GT 229
GT
Sbjct: 119 GT 120
Score = 40.8 bits (94), Expect = 0.015
Identities = 20/50 (40%), Positives = 28/50 (56%), Gaps = 1/50 (2%)
Query: 49 SNGESYSGTLFGNTPEGHGTYVWSDRCVYEGGWRRGMRHGNG-KIRWPYG 97
S+G Y GT +G+GT ++D Y+G + GMRHG G + PYG
Sbjct: 101 SSGAKYEGTWNNGLQDGYGTETYADGGTYQGQFTNGMRHGYGVRQSVPYG 150
Score = 38.5 bits (88), Expect = 0.072
Identities = 18/49 (36%), Positives = 23/49 (46%)
Query: 164 TNGNVYVGNMKGGTMSGKGTLTWINGDSYEGSWLNGMMHGFGAYTWSGG 212
T Y+G K SG G +G YEG WL+ + HG+G T G
Sbjct: 285 TTTETYMGEWKNDKRSGFGVSERSSGLRYEGEWLDNLRHGYGCTTLPDG 333
Score = 37.0 bits (84), Expect = 0.21
Identities = 27/100 (27%), Positives = 43/100 (43%), Gaps = 3/100 (3%)
Query: 8 QRETKSF---NASSEINNNLSLVTIGEAGHSSEIDSFSVGELLLSNGESYSGTLFGNTPE 64
QR SF + SS ++ S ++GE ++ + ++ + E+Y G +
Sbjct: 241 QRSRVSFLKSDLSSGASDAASTASLGEGAEGADDAAPFEADIDATTTETYMGEWKNDKRS 300
Query: 65 GHGTYVWSDRCVYEGGWRRGMRHGNGKIRWPYGAVYEGEF 104
G G S YEG W +RHG G P G EG++
Sbjct: 301 GFGVSERSSGLRYEGEWLDNLRHGYGCTTLPDGHREEGKY 340
Score = 36.6 bits (83), Expect = 0.27
Identities = 19/51 (37%), Positives = 24/51 (46%)
Query: 100 YEGEFSGGYIQGTGKYIGSDHLTYKGRWRLNLKHGLGYQVYPNGDILEGSW 150
Y GE+ G G S L Y+G W NL+HG G P+G EG +
Sbjct: 290 YMGEWKNDKRSGFGVSERSSGLRYEGEWLDNLRHGYGCTTLPDGHREEGKY 340
Score = 33.1 bits (74), Expect = 3.0
Identities = 18/46 (39%), Positives = 21/46 (45%), Gaps = 1/46 (2%)
Query: 190 DSYEGSWLNGMMHGFGAYTWSGGGCYVGTWTCGLKDGKG-TFYPKG 234
++Y G W N GFG S G Y G W L+ G G T P G
Sbjct: 288 ETYMGEWKNDKRSGFGVSERSSGLRYEGEWLDNLRHGYGCTTLPDG 333
>JPH2_MOUSE (Q9ET78) Junctophilin 2 (Junctophilin type 2) (JP-2)
Length = 696
Score = 80.5 bits (197), Expect = 2e-14
Identities = 52/165 (31%), Positives = 75/165 (44%), Gaps = 29/165 (17%)
Query: 67 GTYVWSDRCVYEGGWRRGMRHGNGKIRWPYGAVYEGEFSGGYIQG---TGKYIGSDHLTY 123
G + + D Y GGW G HG+G P G +GE+SG + G G Y T+
Sbjct: 4 GRFDFDDGGAYCGGWEGGKAHGHGLCTGPKG---QGEYSGSWNFGFEVAGVYTWPSGNTF 60
Query: 124 KGRWRLNLKHGLGYQVYPNGDILEGSWIQGTPEGPGKYTWTNGNVYVGNMKGGTMSGKGT 183
+G W +HGLG + +G W+ K WT+G ++ T SG
Sbjct: 61 EGYWSQGKRHGLGIET-------KGRWLY-------KGEWTHGFKGRYGIRQSTNSGA-- 104
Query: 184 LTWINGDSYEGSWLNGMMHGFGAYTWSGGGCYVGTWTCGLKDGKG 228
YEG+W NG+ G+G T++ GG Y G +T G++ G G
Sbjct: 105 -------KYEGTWNNGLQDGYGTETYADGGTYQGQFTNGMRHGYG 142
Score = 62.8 bits (151), Expect = 4e-09
Identities = 43/122 (35%), Positives = 54/122 (44%), Gaps = 10/122 (8%)
Query: 113 GKYIGSDHLTYKGRWRLNLKHGLGYQVYPNGD-ILEGSWIQGTPEGPGKYTWTNGNVYVG 171
G++ D Y G W HG G P G GSW G E G YTW +GN + G
Sbjct: 4 GRFDFDDGGAYCGGWEGGKAHGHGLCTGPKGQGEYSGSWNFGF-EVAGVYTWPSGNTFEG 62
Query: 172 NMKGGTMSGKGTLT---WINGDSYEGSWLNGMMHGFGA-YTWSGGGCYVGTWTCGLKDGK 227
G G G T W+ Y+G W +G +G + + G Y GTW GL+DG
Sbjct: 63 YWSQGKRHGLGIETKGRWL----YKGEWTHGFKGRYGIRQSTNSGAKYEGTWNNGLQDGY 118
Query: 228 GT 229
GT
Sbjct: 119 GT 120
Score = 39.7 bits (91), Expect = 0.032
Identities = 19/50 (38%), Positives = 28/50 (56%), Gaps = 1/50 (2%)
Query: 49 SNGESYSGTLFGNTPEGHGTYVWSDRCVYEGGWRRGMRHGNG-KIRWPYG 97
++G Y GT +G+GT ++D Y+G + GMRHG G + PYG
Sbjct: 101 NSGAKYEGTWNNGLQDGYGTETYADGGTYQGQFTNGMRHGYGVRQSVPYG 150
Score = 38.1 bits (87), Expect = 0.094
Identities = 18/49 (36%), Positives = 23/49 (46%)
Query: 164 TNGNVYVGNMKGGTMSGKGTLTWINGDSYEGSWLNGMMHGFGAYTWSGG 212
T Y+G K SG G +G YEG WL+ + HG+G T G
Sbjct: 280 TTTETYMGEWKNDKRSGFGVSERSSGLRYEGEWLDNLRHGYGRTTLPDG 328
Score = 36.6 bits (83), Expect = 0.27
Identities = 19/51 (37%), Positives = 24/51 (46%)
Query: 100 YEGEFSGGYIQGTGKYIGSDHLTYKGRWRLNLKHGLGYQVYPNGDILEGSW 150
Y GE+ G G S L Y+G W NL+HG G P+G EG +
Sbjct: 285 YMGEWKNDKRSGFGVSERSSGLRYEGEWLDNLRHGYGRTTLPDGHREEGKY 335
Score = 33.9 bits (76), Expect = 1.8
Identities = 18/53 (33%), Positives = 24/53 (44%)
Query: 52 ESYSGTLFGNTPEGHGTYVWSDRCVYEGGWRRGMRHGNGKIRWPYGAVYEGEF 104
E+Y G + G G S YEG W +RHG G+ P G EG++
Sbjct: 283 ETYMGEWKNDKRSGFGVSERSSGLRYEGEWLDNLRHGYGRTTLPDGHREEGKY 335
Score = 33.1 bits (74), Expect = 3.0
Identities = 18/62 (29%), Positives = 28/62 (45%), Gaps = 1/62 (1%)
Query: 122 TYKGRWRLNLKHGLGYQVYPNGDILEGSWIQGTPEGPGKYTWTNGNVYVGNMKGGTMSGK 181
TY G W+ + + G G +G EG W+ G G+ T +G+ G + + K
Sbjct: 284 TYMGEWKNDKRSGFGVSERSSGLRYEGEWLDNLRHGYGRTTLPDGHREEGKYRHNVLV-K 342
Query: 182 GT 183
GT
Sbjct: 343 GT 344
Score = 33.1 bits (74), Expect = 3.0
Identities = 18/46 (39%), Positives = 21/46 (45%), Gaps = 1/46 (2%)
Query: 190 DSYEGSWLNGMMHGFGAYTWSGGGCYVGTWTCGLKDGKG-TFYPKG 234
++Y G W N GFG S G Y G W L+ G G T P G
Sbjct: 283 ETYMGEWKNDKRSGFGVSERSSGLRYEGEWLDNLRHGYGRTTLPDG 328
>JPH2_HUMAN (Q9BR39) Junctophilin 2 (Junctophilin type 2) (JP-2)
Length = 696
Score = 80.1 bits (196), Expect = 2e-14
Identities = 47/143 (32%), Positives = 69/143 (47%), Gaps = 8/143 (5%)
Query: 67 GTYVWSDRCVYEGGWRRGMRHGNGKIRWPYGAVYEGEFSGGYIQG---TGKYIGSDHLTY 123
G + + D Y GGW G HG+G P G +GE+SG + G G Y T+
Sbjct: 4 GRFDFDDGGAYCGGWEGGKAHGHGLCTGPKG---QGEYSGSWNFGFEVAGVYTWPSGNTF 60
Query: 124 KGRWRLNLKHGLGYQVYPNGDILEGSWIQGTPEGPG-KYTWTNGNVYVGNMKGGTMSGKG 182
+G W +HGLG + + +G W G G + + ++G Y G G G G
Sbjct: 61 EGYWSQGKRHGLGIETKGRW-LYKGEWTHGFKGRYGIRQSSSSGAKYEGTWNNGLQDGYG 119
Query: 183 TLTWINGDSYEGSWLNGMMHGFG 205
T T+ +G +Y+G + NGM HG+G
Sbjct: 120 TETYADGGTYQGQFTNGMRHGYG 142
Score = 63.5 bits (153), Expect = 2e-09
Identities = 44/122 (36%), Positives = 53/122 (43%), Gaps = 10/122 (8%)
Query: 113 GKYIGSDHLTYKGRWRLNLKHGLGYQVYPNGD-ILEGSWIQGTPEGPGKYTWTNGNVYVG 171
G++ D Y G W HG G P G GSW G E G YTW +GN + G
Sbjct: 4 GRFDFDDGGAYCGGWEGGKAHGHGLCTGPKGQGEYSGSWNFGF-EVAGVYTWPSGNTFEG 62
Query: 172 NMKGGTMSGKGTLT---WINGDSYEGSWLNGMMHGFGAYTWSGGGC-YVGTWTCGLKDGK 227
G G G T W+ Y+G W +G +G S G Y GTW GL+DG
Sbjct: 63 YWSQGKRHGLGIETKGRWL----YKGEWTHGFKGRYGIRQSSSSGAKYEGTWNNGLQDGY 118
Query: 228 GT 229
GT
Sbjct: 119 GT 120
Score = 40.8 bits (94), Expect = 0.015
Identities = 20/50 (40%), Positives = 28/50 (56%), Gaps = 1/50 (2%)
Query: 49 SNGESYSGTLFGNTPEGHGTYVWSDRCVYEGGWRRGMRHGNG-KIRWPYG 97
S+G Y GT +G+GT ++D Y+G + GMRHG G + PYG
Sbjct: 101 SSGAKYEGTWNNGLQDGYGTETYADGGTYQGQFTNGMRHGYGVRQSVPYG 150
Score = 38.5 bits (88), Expect = 0.072
Identities = 18/49 (36%), Positives = 23/49 (46%)
Query: 164 TNGNVYVGNMKGGTMSGKGTLTWINGDSYEGSWLNGMMHGFGAYTWSGG 212
T Y+G K SG G +G YEG WL+ + HG+G T G
Sbjct: 286 TTTETYMGEWKNDKRSGFGVSERSSGLRYEGEWLDNLRHGYGCTTLPDG 334
Score = 38.5 bits (88), Expect = 0.072
Identities = 28/100 (28%), Positives = 44/100 (44%), Gaps = 3/100 (3%)
Query: 8 QRETKSF---NASSEINNNLSLVTIGEAGHSSEIDSFSVGELLLSNGESYSGTLFGNTPE 64
QR SF + SS ++ S ++GEA ++ + ++ + E+Y G +
Sbjct: 242 QRSRVSFLKSDLSSGASDAASTASLGEAAEGADEAAPFEADIDATTTETYMGEWKNDKRS 301
Query: 65 GHGTYVWSDRCVYEGGWRRGMRHGNGKIRWPYGAVYEGEF 104
G G S YEG W +RHG G P G EG++
Sbjct: 302 GFGVSERSSGLRYEGEWLDNLRHGYGCTTLPDGHREEGKY 341
Score = 36.6 bits (83), Expect = 0.27
Identities = 19/51 (37%), Positives = 24/51 (46%)
Query: 100 YEGEFSGGYIQGTGKYIGSDHLTYKGRWRLNLKHGLGYQVYPNGDILEGSW 150
Y GE+ G G S L Y+G W NL+HG G P+G EG +
Sbjct: 291 YMGEWKNDKRSGFGVSERSSGLRYEGEWLDNLRHGYGCTTLPDGHREEGKY 341
Score = 33.1 bits (74), Expect = 3.0
Identities = 18/46 (39%), Positives = 21/46 (45%), Gaps = 1/46 (2%)
Query: 190 DSYEGSWLNGMMHGFGAYTWSGGGCYVGTWTCGLKDGKG-TFYPKG 234
++Y G W N GFG S G Y G W L+ G G T P G
Sbjct: 289 ETYMGEWKNDKRSGFGVSERSSGLRYEGEWLDNLRHGYGCTTLPDG 334
>JPH1_RABIT (Q9GKY8) Junctophilin 1 (Junctophilin type 1) (JP-1)
(Mitsugumin 72) (MG72)
Length = 662
Score = 79.0 bits (193), Expect = 5e-14
Identities = 51/165 (30%), Positives = 72/165 (42%), Gaps = 29/165 (17%)
Query: 67 GTYVWSDRCVYEGGWRRGMRHGNGKIRWPYGAVYEGEFSGGYIQG---TGKYIGSDHLTY 123
G + + D Y GGW G HG+G P G +GE+SG + G G Y TY
Sbjct: 4 GRFDFDDGGTYCGGWEEGKAHGHGICTGPKG---QGEYSGSWSHGFEVVGGYTWPSGNTY 60
Query: 124 KGRWRLNLKHGLGYQVYPNGDILEGSWIQGTPEGPGKYTWTNGNVYVGNMKGGTMSGKGT 183
+G W +HGLG + +G W+ + W++G KG +
Sbjct: 61 QGYWAQGKRHGLGVET-------KGKWMY-------RGEWSHG------FKGRYGVRQSL 100
Query: 184 LTWINGDSYEGSWLNGMMHGFGAYTWSGGGCYVGTWTCGLKDGKG 228
T YEG+W NG+ G+G T+ GG Y G W G++ G G
Sbjct: 101 CT---PARYEGTWSNGLQDGYGVETYGDGGTYQGQWAGGMRHGYG 142
Score = 48.9 bits (115), Expect = 5e-05
Identities = 34/106 (32%), Positives = 45/106 (42%), Gaps = 24/106 (22%)
Query: 54 YSGTLFGNTPEGHGTYVWSDRCVYEGGWRRGMRHGNG---KIRWPYG------------- 97
YSG+ + + E G Y W Y+G W +G RHG G K +W Y
Sbjct: 38 YSGS-WSHGFEVVGGYTWPSGNTYQGYWAQGKRHGLGVETKGKWMYRGEWSHGFKGRYGV 96
Query: 98 -------AVYEGEFSGGYIQGTGKYIGSDHLTYKGRWRLNLKHGLG 136
A YEG +S G G G D TY+G+W ++HG G
Sbjct: 97 RQSLCTPARYEGTWSNGLQDGYGVETYGDGGTYQGQWAGGMRHGYG 142
Score = 46.2 bits (108), Expect = 3e-04
Identities = 66/261 (25%), Positives = 87/261 (33%), Gaps = 56/261 (21%)
Query: 54 YSGTLFGNTPEGHGTYVWSDRCVYEGGWRRGMRHGNG-KIRWPYG-------------AV 99
Y GT +G+G + D Y+G W GMRHG G + PYG A
Sbjct: 106 YEGTWSNGLQDGYGVETYGDGGTYQGQWAGGMRHGYGVRQSVPYGMATVIRSPLRTSLAS 165
Query: 100 YEGEFSGGYIQGTGKYIGSDHLTYKGRWRLNL----------KHGLGYQVYPNGDILEGS 149
E S G + +G + LN K GL + G +L GS
Sbjct: 166 LRSEQSNGSVLHDAAAAADTPTGTRGGFVLNFHADAELAGKKKGGL----FRRGSLL-GS 220
Query: 150 WIQGTPEGPGKYTWTNGNVYVGNMKGGTMSGKGTLTWINGD------------------S 191
E + +V S T GD +
Sbjct: 221 MKLRKSESKSSISSKRSSVRSDAAMSRISSSDANSTISFGDVDCDFCPVEDHVDATTTET 280
Query: 192 YEGSWLNGMMHGFGAYTWSGGGCYVGTWTCGLKDGKG-TFYPKGSHLTSAQEIYLNALRK 250
Y G W N +GFG S G Y G W + G G T +P GS + Y N +
Sbjct: 281 YMGEWKNDKRNGFGISERSNGMKYEGEWANNKRHGYGCTVFPDGS---KEEGKYKNNILV 337
Query: 251 RGLLPDLRKQNL-VRGVKVGE 270
RG +RKQ + +R K E
Sbjct: 338 RG----IRKQLIPIRNTKTRE 354
Score = 35.8 bits (81), Expect = 0.47
Identities = 19/55 (34%), Positives = 27/55 (48%), Gaps = 1/55 (1%)
Query: 182 GTLTWINGDSYEGSWLNGMMHGFGAYTW-SGGGCYVGTWTCGLKDGKGTFYPKGS 235
G + +G +Y G W G HG G T G G Y G+W+ G + G +P G+
Sbjct: 4 GRFDFDDGGTYCGGWEEGKAHGHGICTGPKGQGEYSGSWSHGFEVVGGYTWPSGN 58
Score = 34.7 bits (78), Expect = 1.0
Identities = 18/58 (31%), Positives = 26/58 (44%)
Query: 52 ESYSGTLFGNTPEGHGTYVWSDRCVYEGGWRRGMRHGNGKIRWPYGAVYEGEFSGGYI 109
E+Y G + G G S+ YEG W RHG G +P G+ EG++ +
Sbjct: 279 ETYMGEWKNDKRNGFGISERSNGMKYEGEWANNKRHGYGCTVFPDGSKEEGKYKNNIL 336
>JPH1_MOUSE (Q9ET80) Junctophilin 1 (Junctophilin type 1) (JP-1)
Length = 660
Score = 79.0 bits (193), Expect = 5e-14
Identities = 51/165 (30%), Positives = 72/165 (42%), Gaps = 29/165 (17%)
Query: 67 GTYVWSDRCVYEGGWRRGMRHGNGKIRWPYGAVYEGEFSGGYIQG---TGKYIGSDHLTY 123
G + + D Y GGW G HG+G P G +GE+SG + G G Y TY
Sbjct: 4 GRFDFDDGGTYCGGWEEGKAHGHGICTGPKG---QGEYSGSWSHGFEVVGVYTWPSGNTY 60
Query: 124 KGRWRLNLKHGLGYQVYPNGDILEGSWIQGTPEGPGKYTWTNGNVYVGNMKGGTMSGKGT 183
+G W +HGLG + +G W+ + W++G KG +
Sbjct: 61 QGYWAQGKRHGLGVET-------KGKWMY-------RGEWSHG------FKGRYGVRQSL 100
Query: 184 LTWINGDSYEGSWLNGMMHGFGAYTWSGGGCYVGTWTCGLKDGKG 228
T YEG+W NG+ G+G T+ GG Y G W G++ G G
Sbjct: 101 CT---PARYEGTWSNGLQDGYGVETYGDGGTYQGQWAGGMRHGYG 142
Score = 49.7 bits (117), Expect = 3e-05
Identities = 34/106 (32%), Positives = 45/106 (42%), Gaps = 24/106 (22%)
Query: 54 YSGTLFGNTPEGHGTYVWSDRCVYEGGWRRGMRHGNG---KIRWPYG------------- 97
YSG+ + + E G Y W Y+G W +G RHG G K +W Y
Sbjct: 38 YSGS-WSHGFEVVGVYTWPSGNTYQGYWAQGKRHGLGVETKGKWMYRGEWSHGFKGRYGV 96
Query: 98 -------AVYEGEFSGGYIQGTGKYIGSDHLTYKGRWRLNLKHGLG 136
A YEG +S G G G D TY+G+W ++HG G
Sbjct: 97 RQSLCTPARYEGTWSNGLQDGYGVETYGDGGTYQGQWAGGMRHGYG 142
Score = 47.0 bits (110), Expect = 2e-04
Identities = 65/260 (25%), Positives = 87/260 (33%), Gaps = 54/260 (20%)
Query: 54 YSGTLFGNTPEGHGTYVWSDRCVYEGGWRRGMRHGNG-KIRWPYG-------------AV 99
Y GT +G+G + D Y+G W GMRHG G + PYG A
Sbjct: 106 YEGTWSNGLQDGYGVETYGDGGTYQGQWAGGMRHGYGVRQSVPYGMATVIRSPLRTSLAS 165
Query: 100 YEGEFSGGYIQGTGKYIGSDH---------LTYKGRWRLNLKHGLGYQVYPNGDILEGSW 150
E S G + +D L + L K G ++ G +L GS
Sbjct: 166 LRSEQSNGSVLHEAAAAAADSPAGTRGGFVLNFHADTELGKKKG---GLFRRGSLL-GSM 221
Query: 151 IQGTPEGPGKYTWTNGNVYVGNMKGGTMSGKGTLTWINGD------------------SY 192
E + +V S T GD +Y
Sbjct: 222 KLRKSESKSSISSKRSSVRSDAAMSRISSSDANSTISFGDVDCDFCPVEDHVDATTTETY 281
Query: 193 EGSWLNGMMHGFGAYTWSGGGCYVGTWTCGLKDGKG-TFYPKGSHLTSAQEIYLNALRKR 251
G W N +GFG S G Y G W + G G T +P GS + Y N + R
Sbjct: 282 MGEWKNDKRNGFGISERSNGMKYEGEWANNKRHGYGCTVFPDGS---KEEGKYKNNILVR 338
Query: 252 GLLPDLRKQNL-VRGVKVGE 270
G +RKQ + +R K E
Sbjct: 339 G----IRKQLIPIRNTKTRE 354
Score = 34.7 bits (78), Expect = 1.0
Identities = 18/58 (31%), Positives = 26/58 (44%)
Query: 52 ESYSGTLFGNTPEGHGTYVWSDRCVYEGGWRRGMRHGNGKIRWPYGAVYEGEFSGGYI 109
E+Y G + G G S+ YEG W RHG G +P G+ EG++ +
Sbjct: 279 ETYMGEWKNDKRNGFGISERSNGMKYEGEWANNKRHGYGCTVFPDGSKEEGKYKNNIL 336
>JPH1_HUMAN (Q9HDC5) Junctophilin 1 (Junctophilin type 1) (JP-1)
Length = 661
Score = 79.0 bits (193), Expect = 5e-14
Identities = 51/165 (30%), Positives = 72/165 (42%), Gaps = 29/165 (17%)
Query: 67 GTYVWSDRCVYEGGWRRGMRHGNGKIRWPYGAVYEGEFSGGYIQG---TGKYIGSDHLTY 123
G + + D Y GGW G HG+G P G +GE+SG + G G Y TY
Sbjct: 4 GRFDFDDGGTYCGGWEEGKAHGHGICTGPKG---QGEYSGSWSHGFEVVGGYTWPSGNTY 60
Query: 124 KGRWRLNLKHGLGYQVYPNGDILEGSWIQGTPEGPGKYTWTNGNVYVGNMKGGTMSGKGT 183
+G W +HGLG + +G W+ + W++G KG +
Sbjct: 61 QGYWAQGKRHGLGVET-------KGKWMY-------RGEWSHG------FKGRYGVRQSL 100
Query: 184 LTWINGDSYEGSWLNGMMHGFGAYTWSGGGCYVGTWTCGLKDGKG 228
T YEG+W NG+ G+G T+ GG Y G W G++ G G
Sbjct: 101 CT---PARYEGTWSNGLQDGYGVETYGDGGTYQGQWAGGMRHGYG 142
Score = 48.9 bits (115), Expect = 5e-05
Identities = 34/106 (32%), Positives = 45/106 (42%), Gaps = 24/106 (22%)
Query: 54 YSGTLFGNTPEGHGTYVWSDRCVYEGGWRRGMRHGNG---KIRWPYG------------- 97
YSG+ + + E G Y W Y+G W +G RHG G K +W Y
Sbjct: 38 YSGS-WSHGFEVVGGYTWPSGNTYQGYWAQGKRHGLGVETKGKWMYRGEWSHGFKGRYGV 96
Query: 98 -------AVYEGEFSGGYIQGTGKYIGSDHLTYKGRWRLNLKHGLG 136
A YEG +S G G G D TY+G+W ++HG G
Sbjct: 97 RQSLCTPARYEGTWSNGLQDGYGVETYGDGGTYQGQWAGGMRHGYG 142
Score = 46.2 bits (108), Expect = 3e-04
Identities = 61/247 (24%), Positives = 80/247 (31%), Gaps = 51/247 (20%)
Query: 54 YSGTLFGNTPEGHGTYVWSDRCVYEGGWRRGMRHGNG-KIRWPYG-------------AV 99
Y GT +G+G + D Y+G W GMRHG G + PYG A
Sbjct: 106 YEGTWSNGLQDGYGVETYGDGGTYQGQWAGGMRHGYGVRQSVPYGMATVIRSPLRTSLAS 165
Query: 100 YEGEFSGGYIQGTGKYIGSDHLTYKGRWRLNL----------KHGLGYQVYPNGDILEGS 149
E S G + +G + LN K GL + G +L GS
Sbjct: 166 LRSEQSNGSVLHDAAAAADSPAGTRGGFVLNFHADAELAGKKKGGL----FRRGSLL-GS 220
Query: 150 WIQGTPEGPGKYTWTNGNVYVGNMKGGTMSGKGTLTWINGD------------------S 191
E + +V S T GD +
Sbjct: 221 MKLRKSESKSSISSKRSSVRSDAAMSRISSSDANSTISFGDVDCDFCPVEDHVDATTTET 280
Query: 192 YEGSWLNGMMHGFGAYTWSGGGCYVGTWTCGLKDGKG-TFYPKGSHLTSAQEIYLNALRK 250
Y G W N +GFG S G Y G W + G G T +P GS + Y N +
Sbjct: 281 YMGEWKNDKRNGFGVSERSNGMKYEGEWANNKRHGYGCTVFPDGS---KEEGKYKNNILV 337
Query: 251 RGLLPDL 257
RG+ L
Sbjct: 338 RGIRKQL 344
Score = 38.1 bits (87), Expect = 0.094
Identities = 17/49 (34%), Positives = 21/49 (42%)
Query: 164 TNGNVYVGNMKGGTMSGKGTLTWINGDSYEGSWLNGMMHGFGAYTWSGG 212
T Y+G K +G G NG YEG W N HG+G + G
Sbjct: 276 TTTETYMGEWKNDKRNGFGVSERSNGMKYEGEWANNKRHGYGCTVFPDG 324
Score = 38.1 bits (87), Expect = 0.094
Identities = 18/51 (35%), Positives = 26/51 (50%)
Query: 100 YEGEFSGGYIQGTGKYIGSDHLTYKGRWRLNLKHGLGYQVYPNGDILEGSW 150
Y GE+ G G S+ + Y+G W N +HG G V+P+G EG +
Sbjct: 281 YMGEWKNDKRNGFGVSERSNGMKYEGEWANNKRHGYGCTVFPDGSKEEGKY 331
Score = 35.8 bits (81), Expect = 0.47
Identities = 19/55 (34%), Positives = 27/55 (48%), Gaps = 1/55 (1%)
Query: 182 GTLTWINGDSYEGSWLNGMMHGFGAYTW-SGGGCYVGTWTCGLKDGKGTFYPKGS 235
G + +G +Y G W G HG G T G G Y G+W+ G + G +P G+
Sbjct: 4 GRFDFDDGGTYCGGWEEGKAHGHGICTGPKGQGEYSGSWSHGFEVVGGYTWPSGN 58
Score = 35.0 bits (79), Expect = 0.80
Identities = 18/58 (31%), Positives = 26/58 (44%)
Query: 52 ESYSGTLFGNTPEGHGTYVWSDRCVYEGGWRRGMRHGNGKIRWPYGAVYEGEFSGGYI 109
E+Y G + G G S+ YEG W RHG G +P G+ EG++ +
Sbjct: 279 ETYMGEWKNDKRNGFGVSERSNGMKYEGEWANNKRHGYGCTVFPDGSKEEGKYKNNIL 336
>JPH4_MOUSE (Q80WT0) Junctophilin 4 (Junctophilin-like 1 protein)
Length = 628
Score = 77.8 bits (190), Expect = 1e-13
Identities = 53/165 (32%), Positives = 69/165 (41%), Gaps = 30/165 (18%)
Query: 67 GTYVWSDRCVYEGGWRRGMRHGNGKIRWPYGAVYEGEFSGGYIQGTGKYIGSDHLTYKGR 126
G + + D Y GGW G HG G P GA +GE+SG + G
Sbjct: 5 GKFDFDDGGCYVGGWEAGRAHGYGVCTGP-GA--QGEYSGCWAHGF-------------- 47
Query: 127 WRLNLKHGLGYQVYPNGDILEGSWIQGTPEGPG---KYTWTNGNVYVGNMKGGTMSGKGT 183
LG P G +G W QG EG G K WT ++G +KG + G
Sbjct: 48 ------ESLGVFTGPGGHSYQGHWQQGKREGLGVERKSRWTYRGEWLGGLKGRS----GV 97
Query: 184 LTWINGDSYEGSWLNGMMHGFGAYTWSGGGCYVGTWTCGLKDGKG 228
++G Y G W +G G+G T+S GG Y G W G + G G
Sbjct: 98 WESVSGLRYAGLWKDGFQDGYGTETYSDGGTYQGQWQAGKRHGYG 142
Score = 54.7 bits (130), Expect = 1e-06
Identities = 38/121 (31%), Positives = 47/121 (38%), Gaps = 9/121 (7%)
Query: 113 GKYIGSDHLTYKGRWRLNLKHGLGYQVYPNGD-ILEGSWIQGTPEGPGKYTWTNGNVYVG 171
GK+ D Y G W HG G P G W G E G +T G+ Y G
Sbjct: 5 GKFDFDDGGCYVGGWEAGRAHGYGVCTGPGAQGEYSGCWAHGF-ESLGVFTGPGGHSYQG 63
Query: 172 NMKGGTMSGKGT---LTWINGDSYEGSWLNGMMHGFGAYTWSGGGCYVGTWTCGLKDGKG 228
+ + G G G W +Y G WL G+ G + G Y G W G +DG G
Sbjct: 64 HWQQGKREGLGVERKSRW----TYRGEWLGGLKGRSGVWESVSGLRYAGLWKDGFQDGYG 119
Query: 229 T 229
T
Sbjct: 120 T 120
Score = 46.2 bits (108), Expect = 3e-04
Identities = 31/95 (32%), Positives = 41/95 (42%), Gaps = 1/95 (1%)
Query: 42 SVGELLLSNGESYSGTLFGNTPEGHGTYVWSDRCVYEGGWRRGMRHGNGKIRWPYGAVYE 101
S+G G SY G EG G S R Y G W G++ +G G Y
Sbjct: 49 SLGVFTGPGGHSYQGHWQQGKREGLGVERKS-RWTYRGEWLGGLKGRSGVWESVSGLRYA 107
Query: 102 GEFSGGYIQGTGKYIGSDHLTYKGRWRLNLKHGLG 136
G + G+ G G SD TY+G+W+ +HG G
Sbjct: 108 GLWKDGFQDGYGTETYSDGGTYQGQWQAGKRHGYG 142
Score = 38.1 bits (87), Expect = 0.094
Identities = 20/58 (34%), Positives = 23/58 (39%)
Query: 155 PEGPGKYTWTNGNVYVGNMKGGTMSGKGTLTWINGDSYEGSWLNGMMHGFGAYTWSGG 212
P P + VY G + SG G NG YEG WL HG+G T G
Sbjct: 268 PAPPALIEGSATEVYAGEWRADRRSGYGVSQRSNGLRYEGEWLGNRRHGYGRTTRPDG 325
Score = 37.4 bits (85), Expect = 0.16
Identities = 22/60 (36%), Positives = 26/60 (42%), Gaps = 2/60 (3%)
Query: 178 MSGKGTLTWINGDSYEGSWLNGMMHGFGAYTWSGG-GCYVGTWTCGLKDGKGTFYPKGSH 236
MS G + +G Y G W G HG+G T G G Y G W G + G F G H
Sbjct: 1 MSPGGKFDFDDGGCYVGGWEAGRAHGYGVCTGPGAQGEYSGCWAHGF-ESLGVFTGPGGH 59
Score = 36.6 bits (83), Expect = 0.27
Identities = 22/60 (36%), Positives = 29/60 (47%), Gaps = 1/60 (1%)
Query: 76 VYEGGWRRGMRHGNGKIRWPYGAVYEGEFSGGYIQGTGKYIGSDHLTYKGRWRLN-LKHG 134
VY G WR R G G + G YEGE+ G G G+ D +G+++ N L HG
Sbjct: 281 VYAGEWRADRRSGYGVSQRSNGLRYEGEWLGNRRHGYGRTTRPDGSREEGKYKRNRLVHG 340
Score = 36.2 bits (82), Expect = 0.36
Identities = 19/52 (36%), Positives = 25/52 (47%)
Query: 99 VYEGEFSGGYIQGTGKYIGSDHLTYKGRWRLNLKHGLGYQVYPNGDILEGSW 150
VY GE+ G G S+ L Y+G W N +HG G P+G EG +
Sbjct: 281 VYAGEWRADRRSGYGVSQRSNGLRYEGEWLGNRRHGYGRTTRPDGSREEGKY 332
Score = 35.0 bits (79), Expect = 0.80
Identities = 19/58 (32%), Positives = 25/58 (42%)
Query: 117 GSDHLTYKGRWRLNLKHGLGYQVYPNGDILEGSWIQGTPEGPGKYTWTNGNVYVGNMK 174
GS Y G WR + + G G NG EG W+ G G+ T +G+ G K
Sbjct: 276 GSATEVYAGEWRADRRSGYGVSQRSNGLRYEGEWLGNRRHGYGRTTRPDGSREEGKYK 333
Score = 34.7 bits (78), Expect = 1.0
Identities = 18/53 (33%), Positives = 26/53 (48%)
Query: 52 ESYSGTLFGNTPEGHGTYVWSDRCVYEGGWRRGMRHGNGKIRWPYGAVYEGEF 104
E Y+G + G+G S+ YEG W RHG G+ P G+ EG++
Sbjct: 280 EVYAGEWRADRRSGYGVSQRSNGLRYEGEWLGNRRHGYGRTTRPDGSREEGKY 332
>JPH4_HUMAN (Q96JJ6) Junctophilin 4 (Junctophilin-like 1 protein)
Length = 628
Score = 77.8 bits (190), Expect = 1e-13
Identities = 53/165 (32%), Positives = 69/165 (41%), Gaps = 30/165 (18%)
Query: 67 GTYVWSDRCVYEGGWRRGMRHGNGKIRWPYGAVYEGEFSGGYIQGTGKYIGSDHLTYKGR 126
G + + D Y GGW G HG G P GA +GE+SG + G
Sbjct: 5 GKFDFDDGGCYVGGWEAGRAHGYGVCTGP-GA--QGEYSGCWAHGF-------------- 47
Query: 127 WRLNLKHGLGYQVYPNGDILEGSWIQGTPEGPG---KYTWTNGNVYVGNMKGGTMSGKGT 183
LG P G +G W QG EG G K WT ++G +KG + G
Sbjct: 48 ------ESLGVFTGPGGHSYQGHWQQGKREGLGVERKSRWTYRGEWLGGLKGRS----GV 97
Query: 184 LTWINGDSYEGSWLNGMMHGFGAYTWSGGGCYVGTWTCGLKDGKG 228
++G Y G W +G G+G T+S GG Y G W G + G G
Sbjct: 98 WESVSGLRYAGLWKDGFQDGYGTETYSDGGTYQGQWQAGKRHGYG 142
Score = 54.7 bits (130), Expect = 1e-06
Identities = 38/121 (31%), Positives = 47/121 (38%), Gaps = 9/121 (7%)
Query: 113 GKYIGSDHLTYKGRWRLNLKHGLGYQVYPNGD-ILEGSWIQGTPEGPGKYTWTNGNVYVG 171
GK+ D Y G W HG G P G W G E G +T G+ Y G
Sbjct: 5 GKFDFDDGGCYVGGWEAGRAHGYGVCTGPGAQGEYSGCWAHGF-ESLGVFTGPGGHSYQG 63
Query: 172 NMKGGTMSGKGT---LTWINGDSYEGSWLNGMMHGFGAYTWSGGGCYVGTWTCGLKDGKG 228
+ + G G G W +Y G WL G+ G + G Y G W G +DG G
Sbjct: 64 HWQQGKREGLGVERKSRW----TYRGEWLGGLKGRSGVWESVSGLRYAGLWKDGFQDGYG 119
Query: 229 T 229
T
Sbjct: 120 T 120
Score = 46.2 bits (108), Expect = 3e-04
Identities = 31/95 (32%), Positives = 41/95 (42%), Gaps = 1/95 (1%)
Query: 42 SVGELLLSNGESYSGTLFGNTPEGHGTYVWSDRCVYEGGWRRGMRHGNGKIRWPYGAVYE 101
S+G G SY G EG G S R Y G W G++ +G G Y
Sbjct: 49 SLGVFTGPGGHSYQGHWQQGKREGLGVERKS-RWTYRGEWLGGLKGRSGVWESVSGLRYA 107
Query: 102 GEFSGGYIQGTGKYIGSDHLTYKGRWRLNLKHGLG 136
G + G+ G G SD TY+G+W+ +HG G
Sbjct: 108 GLWKDGFQDGYGTETYSDGGTYQGQWQAGKRHGYG 142
Score = 37.7 bits (86), Expect = 0.12
Identities = 23/67 (34%), Positives = 26/67 (38%), Gaps = 2/67 (2%)
Query: 148 GSWIQGTPEG--PGKYTWTNGNVYVGNMKGGTMSGKGTLTWINGDSYEGSWLNGMMHGFG 205
GS G P P + VY G + SG G NG YEG WL HG+G
Sbjct: 259 GSEASGPPAAAPPALIEGSATEVYAGEWRADRRSGFGVSQRSNGLRYEGEWLGNRRHGYG 318
Query: 206 AYTWSGG 212
T G
Sbjct: 319 RTTRPDG 325
Score = 37.4 bits (85), Expect = 0.16
Identities = 22/60 (36%), Positives = 26/60 (42%), Gaps = 2/60 (3%)
Query: 178 MSGKGTLTWINGDSYEGSWLNGMMHGFGAYTWSGG-GCYVGTWTCGLKDGKGTFYPKGSH 236
MS G + +G Y G W G HG+G T G G Y G W G + G F G H
Sbjct: 1 MSPGGKFDFDDGGCYVGGWEAGRAHGYGVCTGPGAQGEYSGCWAHGF-ESLGVFTGPGGH 59
Score = 36.2 bits (82), Expect = 0.36
Identities = 22/60 (36%), Positives = 29/60 (47%), Gaps = 1/60 (1%)
Query: 76 VYEGGWRRGMRHGNGKIRWPYGAVYEGEFSGGYIQGTGKYIGSDHLTYKGRWRLN-LKHG 134
VY G WR R G G + G YEGE+ G G G+ D +G+++ N L HG
Sbjct: 281 VYAGEWRADRRSGFGVSQRSNGLRYEGEWLGNRRHGYGRTTRPDGSREEGKYKRNRLVHG 340
Score = 36.2 bits (82), Expect = 0.36
Identities = 19/52 (36%), Positives = 25/52 (47%)
Query: 99 VYEGEFSGGYIQGTGKYIGSDHLTYKGRWRLNLKHGLGYQVYPNGDILEGSW 150
VY GE+ G G S+ L Y+G W N +HG G P+G EG +
Sbjct: 281 VYAGEWRADRRSGFGVSQRSNGLRYEGEWLGNRRHGYGRTTRPDGSREEGKY 332
Score = 35.4 bits (80), Expect = 0.61
Identities = 19/58 (32%), Positives = 25/58 (42%)
Query: 117 GSDHLTYKGRWRLNLKHGLGYQVYPNGDILEGSWIQGTPEGPGKYTWTNGNVYVGNMK 174
GS Y G WR + + G G NG EG W+ G G+ T +G+ G K
Sbjct: 276 GSATEVYAGEWRADRRSGFGVSQRSNGLRYEGEWLGNRRHGYGRTTRPDGSREEGKYK 333
Score = 33.5 bits (75), Expect = 2.3
Identities = 18/53 (33%), Positives = 25/53 (46%)
Query: 52 ESYSGTLFGNTPEGHGTYVWSDRCVYEGGWRRGMRHGNGKIRWPYGAVYEGEF 104
E Y+G + G G S+ YEG W RHG G+ P G+ EG++
Sbjct: 280 EVYAGEWRADRRSGFGVSQRSNGLRYEGEWLGNRRHGYGRTTRPDGSREEGKY 332
>FYV1_HUMAN (Q9Y2I7) FYVE finger-containing phosphoinositide kinase
(EC 2.7.1.68) (1-phosphatidylinositol-4-phosphate
5-kinase) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235)
Length = 2098
Score = 73.6 bits (179), Expect = 2e-12
Identities = 68/222 (30%), Positives = 107/222 (47%), Gaps = 40/222 (18%)
Query: 443 QSEDFKWKDYCPMV----FRNLRELFKIDAADYMISICGNDALRELS--SP-----GKSG 491
Q D K YC + F +RE+ +D+++ D +R LS SP GKSG
Sbjct: 1812 QFSDANAKFYCRLYYAGEFHKMREVI-LDSSE-------EDFIRSLSHSSPWQARGGKSG 1863
Query: 492 SVFFLSQDDRFMIKTLRKSELKIFLRMLPDYHHH----VKSYENTLITKFFGLHRIKPSS 547
+ F+ ++DDRF++K + + E++ FL P Y ++ V+ T + K G++RI +
Sbjct: 1864 AAFYATEDDRFILKQMPRLEVQSFLDFAPHYFNYITNAVQQKRPTALAKILGVYRIGYKN 1923
Query: 548 GQ-----KFRFAVMGNMFCTELRIHRRFDLKGSSFGR---------SSDKIEIDENTTLK 593
Q K VM N+F ++ + FDLKGS R S D + +DEN L
Sbjct: 1924 SQNNTEKKLDLLVMENLFYGR-KMAQVFDLKGSLRNRNVKTDTGKESCDVVLLDEN--LL 1980
Query: 594 DLDLNYSFFLEPSWRDSLLNQIKIDSKFLEAQHIMDYSLLLG 635
+ + ++ + L I DS FL + I+DYSLL+G
Sbjct: 1981 KMVRDNPLYIRSHSKAVLRTSIHSDSHFLSSHLIIDYSLLVG 2022
Score = 33.1 bits (74), Expect = 3.0
Identities = 21/55 (38%), Positives = 27/55 (48%), Gaps = 3/55 (5%)
Query: 757 LYLGIIDILQDYNMTKKLEHAYKS---LQFDSVSISVVDPAFYSRRFLEFIQKVF 808
L +GIID ++ + KKLE KS L +VV P Y RF E + K F
Sbjct: 2030 LVVGIIDYIRTFTWDKKLEMVVKSTGILGGQGKMPTVVSPELYRTRFCEAMDKYF 2084
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.318 0.137 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 101,796,213
Number of Sequences: 164201
Number of extensions: 4847267
Number of successful extensions: 11292
Number of sequences better than 10.0: 49
Number of HSP's better than 10.0 without gapping: 30
Number of HSP's successfully gapped in prelim test: 20
Number of HSP's that attempted gapping in prelim test: 10809
Number of HSP's gapped (non-prelim): 248
length of query: 815
length of database: 59,974,054
effective HSP length: 119
effective length of query: 696
effective length of database: 40,434,135
effective search space: 28142157960
effective search space used: 28142157960
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 70 (31.6 bits)
Lotus: description of TM0012b.5