BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= TM0010.22
(235 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
CIA1_HUMAN (O76071) WD-repeat containing protein Ciao 1 251 8e-67
YS00_ANASP (Q8YTC2) Hypothetical WD-repeat protein alr2800 117 3e-26
YY46_ANASP (Q8YRI1) Hypothetical WD-repeat protein alr3466 108 1e-23
HET1_PODAN (Q00808) Vegetatible incompatibility protein HET-E-1 108 1e-23
LIS1_RAT (P63004) Platelet-activating factor acetylhydrolase IB ... 98 1e-20
LIS1_MOUSE (P63005) Platelet-activating factor acetylhydrolase I... 98 1e-20
LIS1_HUMAN (P43034) Platelet-activating factor acetylhydrolase I... 98 1e-20
LIS1_BOVIN (P43033) Platelet-activating factor acetylhydrolase I... 98 2e-20
YL24_ANASP (Q8YV57) Hypothetical WD-repeat protein all2124 94 2e-19
WDR5_MOUSE (P61965) WD-repeat protein 5 (WD-repeat protein BIG-3) 94 2e-19
WDR5_HUMAN (P61964) WD-repeat protein 5 94 2e-19
PRP4_HUMAN (O43172) U4/U6 small nuclear ribonucleoprotein Prp4 (... 92 1e-18
HUS7_MOUSE (Q8VEJ4) WD-repeat protein HUSSY-07 92 1e-18
HUS7_HUMAN (Q9NVX2) WD-repeat protein HUSSY-07 92 1e-18
EBI_DROME (Q95RJ9) F-box-like/WD-repeat protein ebi 91 2e-18
PKWA_THECU (P49695) Probable serine/threonine-protein kinase pkw... 88 2e-17
YKY4_CAEEL (Q17963) Hypothetical WD-repeat protein C14B1.4 in ch... 88 2e-17
WDS_DROME (Q9V3J8) Will die slowly protein 87 3e-17
Y163_SYNY3 (Q55563) Hypothetical WD-repeat protein sll0163 86 6e-17
HIRA_DROME (O17468) HIRA protein homolog (dHIRA) 86 6e-17
>CIA1_HUMAN (O76071) WD-repeat containing protein Ciao 1
Length = 339
Score = 251 bits (642), Expect = 8e-67
Identities = 125/220 (56%), Positives = 154/220 (69%), Gaps = 15/220 (6%)
Query: 11 RLEGHND-RVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDETHT 69
R+ H D R W L WNPA GT L ASC GD+ +RIW + S W CK+VL E H
Sbjct: 10 RVPAHPDSRCWFLAWNPA----GTLL--ASCGGDRRIRIWGTEGDS--WICKSVLSEGHQ 61
Query: 70 RTVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTLLA 129
RTVR AWSP G LA+ASFDATT IW+ DFECV TLEGHENEVKSV+W SG LLA
Sbjct: 62 RTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLA 121
Query: 130 TCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVWADEG 189
TCSRDKSVW+WE+ +E+ECVSVL HTQDVK V WHP++++L S SYD+++K++ +E
Sbjct: 122 TCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREE- 180
Query: 190 DSDDWQCVQTLGQPNNGHTSTVWALSFNASGDKMVTCSSN 229
DDW C TL GH STVW+L+F+ SG ++ +CS +
Sbjct: 181 -EDDWVCCATL----EGHESTVWSLAFDPSGQRLASCSDD 215
Score = 115 bits (288), Expect = 9e-26
Identities = 74/223 (33%), Positives = 123/223 (54%), Gaps = 22/223 (9%)
Query: 9 VQRLEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDETH 68
V LEGH + V S+ W P+ + A+CS DK+V +WE D + C +VL+ +H
Sbjct: 98 VTTLEGHENEVKSVAWAPSGN------LLATCSRDKSVWVWEVD-EEDEYECVSVLN-SH 149
Query: 69 TRTVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTLL 128
T+ V+ W PS +LLA+AS+D T ++ D+ C ATLEGHE+ V S++++ SG L
Sbjct: 150 TQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRL 209
Query: 129 ATCSRDKSVWIW-EMQPVNE-----------FECVSVLQG-HTQDVKMVKWHPTEDILIS 175
A+CS D++V IW + P NE ++C+ L G H++ + + W L +
Sbjct: 210 ASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGALAT 269
Query: 176 CSYDNSIKVWADEGDSDDWQCVQTL-GQPNNGHTSTVWALSFN 217
D++I+V+ ++ +SD Q +L + H+ V +++N
Sbjct: 270 ACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWN 312
Score = 74.3 bits (181), Expect = 2e-13
Identities = 55/151 (36%), Positives = 67/151 (43%), Gaps = 25/151 (16%)
Query: 12 LEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDL-----------SSGLWAC 60
LEGH VWSL ++P+ ASCS D+TVRIW Q L S W C
Sbjct: 190 LEGHESTVWSLAFDPSGQR------LASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKC 243
Query: 61 KAVLDETHTRTVRSCAWSPSGKLLATA-SFDATTAIWENVGGD-----FECVATL-EGHE 113
L H+RT+ AW LATA DA E+ D F A L + H
Sbjct: 244 ICTLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHS 303
Query: 114 NEVKSVSWNASGT-LLATCSRDKSVWIWEMQ 143
+V V+WN LLA+CS D V W+ Q
Sbjct: 304 QDVNCVAWNPKEPGLLASCSDDGEVAFWKYQ 334
>YS00_ANASP (Q8YTC2) Hypothetical WD-repeat protein alr2800
Length = 1258
Score = 117 bits (292), Expect = 3e-26
Identities = 72/224 (32%), Positives = 121/224 (53%), Gaps = 30/224 (13%)
Query: 7 KEVQRLEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDE 66
K + LEGH D ++ + ++P + AS S D +VR+W ++S+G C +L E
Sbjct: 969 KYISSLEGHTDFIYGIAFSPDS------QTLASASTDSSVRLW--NISTG--QCFQILLE 1018
Query: 67 THTRTVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGT 126
HT V + + P GK++AT S D T +W G +C+ TL H +++ ++W+ G
Sbjct: 1019 -HTDWVYAVVFHPQGKIIATGSADCTVKLWNISTG--QCLKTLSEHSDKILGMAWSPDGQ 1075
Query: 127 LLATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVWA 186
LLA+ S D+SV +W+ CV +L+GH+ V + P +I+ +CS D ++K+W
Sbjct: 1076 LLASASADQSVRLWD---CCTGRCVGILRGHSNRVYSAIFSPNGEIIATCSTDQTVKIW- 1131
Query: 187 DEGDSDDWQ---CVQTLGQPNNGHTSTVWALSFNASGDKMVTCS 227
DWQ C++TL GHT+ V+ ++F+ G + + S
Sbjct: 1132 ------DWQQGKCLKTL----TGHTNWVFDIAFSPDGKILASAS 1165
Score = 111 bits (277), Expect = 2e-24
Identities = 75/219 (34%), Positives = 118/219 (53%), Gaps = 24/219 (10%)
Query: 9 VQRLEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDETH 68
++ L GH V+S+ ++P G L AS SGDKT+++W D+ G C L H
Sbjct: 719 IKTLTGHEHEVFSVAFHPD----GETL--ASASGDKTIKLW--DIQDG--TCLQTLTG-H 767
Query: 69 TRTVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTLL 128
T VR A+SP G LA+++ D T +W+ G +C+ TL+ H V+SV+++A G L
Sbjct: 768 TDWVRCVAFSPDGNTLASSAADHTIKLWDVSQG--KCLRTLKSHTGWVRSVAFSADGQTL 825
Query: 129 ATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVWADE 188
A+ S D+++ IW + EC+ GHT V + + P IL+S S D +IK+W
Sbjct: 826 ASGSGDRTIKIWN---YHTGECLKTYIGHTNSVYSIAYSPDSKILVSGSGDRTIKLW--- 879
Query: 189 GDSDDWQCVQTLGQPNNGHTSTVWALSFNASGDKMVTCS 227
D C++TL +GHT+ V +++F+ G + S
Sbjct: 880 -DCQTHICIKTL----HGHTNEVCSVAFSPDGQTLACVS 913
Score = 108 bits (270), Expect = 1e-23
Identities = 70/220 (31%), Positives = 116/220 (51%), Gaps = 24/220 (10%)
Query: 10 QRLEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDETHT 69
Q L H D V+++ ++P + A+ S D TV++W ++S+G C L E H+
Sbjct: 1014 QILLEHTDWVYAVVFHPQGK------IIATGSADCTVKLW--NISTG--QCLKTLSE-HS 1062
Query: 70 RTVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTLLA 129
+ AWSP G+LLA+AS D + +W+ G CV L GH N V S ++ +G ++A
Sbjct: 1063 DKILGMAWSPDGQLLASASADQSVRLWDCCTG--RCVGILRGHSNRVYSAIFSPNGEIIA 1120
Query: 130 TCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVWADEG 189
TCS D++V IW+ Q + +C+ L GHT V + + P IL S S+D ++++W
Sbjct: 1121 TCSTDQTVKIWDWQ---QGKCLKTLTGHTNWVFDIAFSPDGKILASASHDQTVRIWDVNT 1177
Query: 190 DSDDWQCVQTLGQPNNGHTSTVWALSFNASGDKMVTCSSN 229
C+ GHT V +++F+ G+ + + S +
Sbjct: 1178 GKCHHICI--------GHTHLVSSVAFSPDGEVVASGSQD 1209
Score = 105 bits (261), Expect = 1e-22
Identities = 63/194 (32%), Positives = 103/194 (52%), Gaps = 18/194 (9%)
Query: 36 VFASCSGDKTVRIWEQDLSSGLWACKAVLDETHTRTVRSCAWSPSGKLLATASFDATTAI 95
+ A+C D VR+WE L C+ H+ VR +SP G++LA+ D +
Sbjct: 656 LLATCDTDCHVRVWEVKSGKLLLICRG-----HSNWVRFVVFSPDGEILASCGADENVKL 710
Query: 96 WENVGGDFECVATLEGHENEVKSVSWNASGTLLATCSRDKSVWIWEMQPVNEFECVSVLQ 155
W G C+ TL GHE+EV SV+++ G LA+ S DK++ +W++Q + C+ L
Sbjct: 711 WSVRDG--VCIKTLTGHEHEVFSVAFHPDGETLASASGDKTIKLWDIQ---DGTCLQTLT 765
Query: 156 GHTQDVKMVKWHPTEDILISCSYDNSIKVWADEGDSDDWQCVQTLGQPNNGHTSTVWALS 215
GHT V+ V + P + L S + D++IK+W D +C++TL HT V +++
Sbjct: 766 GHTDWVRCVAFSPDGNTLASSAADHTIKLW----DVSQGKCLRTL----KSHTGWVRSVA 817
Query: 216 FNASGDKMVTCSSN 229
F+A G + + S +
Sbjct: 818 FSADGQTLASGSGD 831
Score = 99.8 bits (247), Expect = 5e-21
Identities = 58/177 (32%), Positives = 99/177 (55%), Gaps = 16/177 (9%)
Query: 9 VQRLEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDETH 68
++ L H+D++ + W+P + AS S D++VR+W D +G C +L H
Sbjct: 1055 LKTLSEHSDKILGMAWSP------DGQLLASASADQSVRLW--DCCTG--RCVGIL-RGH 1103
Query: 69 TRTVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTLL 128
+ V S +SP+G+++AT S D T IW+ G +C+ TL GH N V ++++ G +L
Sbjct: 1104 SNRVYSAIFSPNGEIIATCSTDQTVKIWDWQQG--KCLKTLTGHTNWVFDIAFSPDGKIL 1161
Query: 129 ATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVW 185
A+ S D++V IW+ VN +C + GHT V V + P +++ S S D ++++W
Sbjct: 1162 ASASHDQTVRIWD---VNTGKCHHICIGHTHLVSSVAFSPDGEVVASGSQDQTVRIW 1215
Score = 94.4 bits (233), Expect = 2e-19
Identities = 62/206 (30%), Positives = 99/206 (47%), Gaps = 18/206 (8%)
Query: 24 WNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDETHTRTVRSCAWSPSGKL 83
W + + AS SGD+T++IW L K + HT +V S A+SP K+
Sbjct: 812 WVRSVAFSADGQTLASGSGDRTIKIWNYHTGECL---KTYIG--HTNSVYSIAYSPDSKI 866
Query: 84 LATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTLLATCSRDKSVWIWEMQ 143
L + S D T +W+ C+ TL GH NEV SV+++ G LA S D+SV +W +
Sbjct: 867 LVSGSGDRTIKLWDCQ--THICIKTLHGHTNEVCSVAFSPDGQTLACVSLDQSVRLWNCR 924
Query: 144 PVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVWADEGDSDDWQCVQTLGQP 203
+C+ G+T V + P IL S S D ++K+W DWQ + +
Sbjct: 925 ---TGQCLKAWYGNTDWALPVAFSPDRQILASGSNDKTVKLW-------DWQTGKYISS- 973
Query: 204 NNGHTSTVWALSFNASGDKMVTCSSN 229
GHT ++ ++F+ + + S++
Sbjct: 974 LEGHTDFIYGIAFSPDSQTLASASTD 999
Score = 93.6 bits (231), Expect = 4e-19
Identities = 59/184 (32%), Positives = 95/184 (51%), Gaps = 15/184 (8%)
Query: 46 VRIWEQDLSSGLWACKAVLDETHTRTVRSCAWSPSGKLLATASFDATTAIWENVGGDFEC 105
V + + D ++ +C V ET + S A+SP G+LLAT D +WE G +
Sbjct: 621 VNLHDVDFANSDLSC-CVFTET-LGNILSAAFSPEGQLLATCDTDCHVRVWEVKSG--KL 676
Query: 106 VATLEGHENEVKSVSWNASGTLLATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVK 165
+ GH N V+ V ++ G +LA+C D++V +W V + C+ L GH +V V
Sbjct: 677 LLICRGHSNWVRFVVFSPDGEILASCGADENVKLWS---VRDGVCIKTLTGHEHEVFSVA 733
Query: 166 WHPTEDILISCSYDNSIKVWADEGDSDDWQCVQTLGQPNNGHTSTVWALSFNASGDKMVT 225
+HP + L S S D +IK+W D D C+QTL GHT V ++F+ G+ + +
Sbjct: 734 FHPDGETLASASGDKTIKLW----DIQDGTCLQTL----TGHTDWVRCVAFSPDGNTLAS 785
Query: 226 CSSN 229
+++
Sbjct: 786 SAAD 789
Score = 87.0 bits (214), Expect = 3e-17
Identities = 62/216 (28%), Positives = 108/216 (49%), Gaps = 24/216 (11%)
Query: 14 GHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDETHTRTVR 73
GH + V+S+ ++P + + S SGD+T+++W+ C L HT V
Sbjct: 850 GHTNSVYSIAYSPDSK------ILVSGSGDRTIKLWDCQTH----ICIKTL-HGHTNEVC 898
Query: 74 SCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTLLATCSR 133
S A+SP G+ LA S D + +W G +C+ G+ + V+++ +LA+ S
Sbjct: 899 SVAFSPDGQTLACVSLDQSVRLWNCRTG--QCLKAWYGNTDWALPVAFSPDRQILASGSN 956
Query: 134 DKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVWADEGDSDD 193
DK+V +W+ Q + +S L+GHT + + + P L S S D+S+++W +
Sbjct: 957 DKTVKLWDWQTG---KYISSLEGHTDFIYGIAFSPDSQTLASASTDSSVRLW----NIST 1009
Query: 194 WQCVQTLGQPNNGHTSTVWALSFNASGDKMVTCSSN 229
QC Q L + HT V+A+ F+ G + T S++
Sbjct: 1010 GQCFQILLE----HTDWVYAVVFHPQGKIIATGSAD 1041
Score = 79.3 bits (194), Expect = 7e-15
Identities = 58/221 (26%), Positives = 110/221 (49%), Gaps = 24/221 (10%)
Query: 9 VQRLEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDETH 68
++ L GH + V S+ ++P G L A S D++VR+W L A +
Sbjct: 887 IKTLHGHTNEVCSVAFSPD----GQTL--ACVSLDQSVRLWNCRTGQCLKAWYG-----N 935
Query: 69 TRTVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTLL 128
T A+SP ++LA+ S D T +W+ G + +++LEGH + + ++++ L
Sbjct: 936 TDWALPVAFSPDRQILASGSNDKTVKLWDWQTGKY--ISSLEGHTDFIYGIAFSPDSQTL 993
Query: 129 ATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVWADE 188
A+ S D SV +W ++ +C +L HT V V +HP I+ + S D ++K+W
Sbjct: 994 ASASTDSSVRLWN---ISTGQCFQILLEHTDWVYAVVFHPQGKIIATGSADCTVKLW--- 1047
Query: 189 GDSDDWQCVQTLGQPNNGHTSTVWALSFNASGDKMVTCSSN 229
+ QC++TL + H+ + ++++ G + + S++
Sbjct: 1048 -NISTGQCLKTLSE----HSDKILGMAWSPDGQLLASASAD 1083
Score = 77.0 bits (188), Expect = 4e-14
Identities = 51/145 (35%), Positives = 79/145 (54%), Gaps = 18/145 (12%)
Query: 12 LEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDETHTRT 71
L GH++RV+S ++P + A+CS D+TV+IW+ L HT
Sbjct: 1100 LRGHSNRVYSAIFSP------NGEIIATCSTDQTVKIWDWQQGKCLKTLTG-----HTNW 1148
Query: 72 VRSCAWSPSGKLLATASFDATTAIWE-NVGGDFECVATLEGHENEVKSVSWNASGTLLAT 130
V A+SP GK+LA+AS D T IW+ N G +C GH + V SV+++ G ++A+
Sbjct: 1149 VFDIAFSPDGKILASASHDQTVRIWDVNTG---KCHHICIGHTHLVSSVAFSPDGEVVAS 1205
Query: 131 CSRDKSVWIWEMQPVNEFECVSVLQ 155
S+D++V IW V EC+ +L+
Sbjct: 1206 GSQDQTVRIWN---VKTGECLQILR 1227
Score = 48.9 bits (115), Expect = 1e-05
Identities = 34/103 (33%), Positives = 51/103 (49%), Gaps = 13/103 (12%)
Query: 7 KEVQRLEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDE 66
K ++ L GH + V+ + ++P + AS S D+TVRIW+ + C
Sbjct: 1137 KCLKTLTGHTNWVFDIAFSP------DGKILASASHDQTVRIWDVNTGKCHHICIG---- 1186
Query: 67 THTRTVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATL 109
HT V S A+SP G+++A+ S D T IW G EC+ L
Sbjct: 1187 -HTHLVSSVAFSPDGEVVASGSQDQTVRIWNVKTG--ECLQIL 1226
>YY46_ANASP (Q8YRI1) Hypothetical WD-repeat protein alr3466
Length = 1526
Score = 108 bits (269), Expect = 1e-23
Identities = 73/214 (34%), Positives = 113/214 (52%), Gaps = 24/214 (11%)
Query: 7 KEVQRLEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDE 66
KE+ +GHN W + G + + AS S D+TVR+W D+SSG C +
Sbjct: 897 KELLTCKGHNS------WVNSVGFSQDGKMLASGSDDQTVRLW--DISSG--QCLKTF-K 945
Query: 67 THTRTVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGT 126
HT VRS +SP+ +LA+ S D T +W+ G EC+ +GH V SV++N G+
Sbjct: 946 GHTSRVRSVVFSPNSLMLASGSSDQTVRLWDISSG--ECLYIFQGHTGWVYSVAFNLDGS 1003
Query: 127 LLATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVWA 186
+LAT S D++V +W+ ++ +C + QGHT V+ V + +L S S D ++++W
Sbjct: 1004 MLATGSGDQTVRLWD---ISSSQCFYIFQGHTSCVRSVVFSSDGAMLASGSDDQTVRLW- 1059
Query: 187 DEGDSDDWQCVQTLGQPNNGHTSTVWALSFNASG 220
D C+ TL GHTS V ++ F+ G
Sbjct: 1060 ---DISSGNCLYTL----QGHTSCVRSVVFSPDG 1086
Score = 103 bits (258), Expect = 3e-22
Identities = 70/209 (33%), Positives = 112/209 (53%), Gaps = 24/209 (11%)
Query: 12 LEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDETHTRT 71
L+GH V S+ +NP G+ L AS S D+TVR+WE + S L + HT
Sbjct: 1196 LQGHTSWVNSVVFNPD----GSTL--ASGSSDQTVRLWEINSSKCLCTFQG-----HTSW 1244
Query: 72 VRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTLLATC 131
V S ++P G +LA+ S D T +W+ +C+ T +GH N V SV++N G++LA+
Sbjct: 1245 VNSVVFNPDGSMLASGSSDKTVRLWDISSS--KCLHTFQGHTNWVNSVAFNPDGSMLASG 1302
Query: 132 SRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVWADEGDS 191
S D++V +WE ++ +C+ QGHT V V + P +L S S D ++++W+
Sbjct: 1303 SGDQTVRLWE---ISSSKCLHTFQGHTSWVSSVTFSPDGTMLASGSDDQTVRLWS----I 1355
Query: 192 DDWQCVQTLGQPNNGHTSTVWALSFNASG 220
+C+ T GHT+ V ++ F+ G
Sbjct: 1356 SSGECLYTF----LGHTNWVGSVIFSPDG 1380
Score = 101 bits (252), Expect = 1e-21
Identities = 69/214 (32%), Positives = 112/214 (52%), Gaps = 24/214 (11%)
Query: 7 KEVQRLEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDE 66
K + +GH + V S+ +NP + AS SGD+TVR+WE S L +
Sbjct: 1275 KCLHTFQGHTNWVNSVAFNPDGS------MLASGSGDQTVRLWEISSSKCLHTFQG---- 1324
Query: 67 THTRTVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGT 126
HT V S +SP G +LA+ S D T +W G EC+ T GH N V SV ++ G
Sbjct: 1325 -HTSWVSSVTFSPDGTMLASGSDDQTVRLWSISSG--ECLYTFLGHTNWVGSVIFSPDGA 1381
Query: 127 LLATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVWA 186
+LA+ S D++V +W ++ +C+ LQGH V + + P +L S S D ++++W
Sbjct: 1382 ILASGSGDQTVRLWS---ISSGKCLYTLQGHNNWVGSIVFSPDGTLLASGSDDQTVRLW- 1437
Query: 187 DEGDSDDWQCVQTLGQPNNGHTSTVWALSFNASG 220
+ +C+ TL +GH ++V +++F++ G
Sbjct: 1438 ---NISSGECLYTL----HGHINSVRSVAFSSDG 1464
Score = 100 bits (248), Expect = 4e-21
Identities = 66/218 (30%), Positives = 111/218 (50%), Gaps = 24/218 (11%)
Query: 12 LEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDETHTRT 71
L+G+ V L ++P + A+ S D+ VR+W+ L+ + HT
Sbjct: 1112 LQGYTSWVRFLVFSP------NGVTLANGSSDQIVRLWDISSKKCLYTLQG-----HTNW 1160
Query: 72 VRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTLLATC 131
V + A+SP G LA+ S D T +W+ +C+ L+GH + V SV +N G+ LA+
Sbjct: 1161 VNAVAFSPDGATLASGSGDQTVRLWDISSS--KCLYILQGHTSWVNSVVFNPDGSTLASG 1218
Query: 132 SRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVWADEGDS 191
S D++V +WE +N +C+ QGHT V V ++P +L S S D ++++W D
Sbjct: 1219 SSDQTVRLWE---INSSKCLCTFQGHTSWVNSVVFNPDGSMLASGSSDKTVRLW----DI 1271
Query: 192 DDWQCVQTLGQPNNGHTSTVWALSFNASGDKMVTCSSN 229
+C+ T GHT+ V +++FN G + + S +
Sbjct: 1272 SSSKCLHTF----QGHTNWVNSVAFNPDGSMLASGSGD 1305
Score = 97.8 bits (242), Expect = 2e-20
Identities = 70/218 (32%), Positives = 116/218 (53%), Gaps = 24/218 (11%)
Query: 12 LEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDETHTRT 71
L+GH V S+ ++P + AS D+ VR+W D+SSG C L + +T
Sbjct: 1070 LQGHTSCVRSVVFSPDGA------MLASGGDDQIVRLW--DISSG--NCLYTL-QGYTSW 1118
Query: 72 VRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTLLATC 131
VR +SP+G LA S D +W+ +C+ TL+GH N V +V+++ G LA+
Sbjct: 1119 VRFLVFSPNGVTLANGSSDQIVRLWDI--SSKKCLYTLQGHTNWVNAVAFSPDGATLASG 1176
Query: 132 SRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVWADEGDS 191
S D++V +W+ ++ +C+ +LQGHT V V ++P L S S D ++++W +
Sbjct: 1177 SGDQTVRLWD---ISSSKCLYILQGHTSWVNSVVFNPDGSTLASGSSDQTVRLW----EI 1229
Query: 192 DDWQCVQTLGQPNNGHTSTVWALSFNASGDKMVTCSSN 229
+ +C+ T GHTS V ++ FN G + + SS+
Sbjct: 1230 NSSKCLCTF----QGHTSWVNSVVFNPDGSMLASGSSD 1263
Score = 97.1 bits (240), Expect = 3e-20
Identities = 69/217 (31%), Positives = 116/217 (52%), Gaps = 24/217 (11%)
Query: 13 EGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDETHTRTV 72
+GH V+S+ +N + A+ SGD+TVR+W D+SS C + + HT V
Sbjct: 987 QGHTGWVYSVAFNLDGS------MLATGSGDQTVRLW--DISSS--QCFYIF-QGHTSCV 1035
Query: 73 RSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTLLATCS 132
RS +S G +LA+ S D T +W+ G+ C+ TL+GH + V+SV ++ G +LA+
Sbjct: 1036 RSVVFSSDGAMLASGSDDQTVRLWDISSGN--CLYTLQGHTSCVRSVVFSPDGAMLASGG 1093
Query: 133 RDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVWADEGDSD 192
D+ V +W++ N C+ LQG+T V+ + + P L + S D +++W D
Sbjct: 1094 DDQIVRLWDISSGN---CLYTLQGYTSWVRFLVFSPNGVTLANGSSDQIVRLW----DIS 1146
Query: 193 DWQCVQTLGQPNNGHTSTVWALSFNASGDKMVTCSSN 229
+C+ TL GHT+ V A++F+ G + + S +
Sbjct: 1147 SKKCLYTL----QGHTNWVNAVAFSPDGATLASGSGD 1179
Score = 96.3 bits (238), Expect = 6e-20
Identities = 68/194 (35%), Positives = 100/194 (51%), Gaps = 20/194 (10%)
Query: 7 KEVQRLEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDE 66
K + +GH V S+ ++P GT L AS S D+TVR+W L+
Sbjct: 1317 KCLHTFQGHTSWVSSVTFSPD----GTML--ASGSDDQTVRLWSISSGECLYTFLG---- 1366
Query: 67 THTRTVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGT 126
HT V S +SP G +LA+ S D T +W G +C+ TL+GH N V S+ ++ GT
Sbjct: 1367 -HTNWVGSVIFSPDGAILASGSGDQTVRLWSISSG--KCLYTLQGHNNWVGSIVFSPDGT 1423
Query: 127 LLATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVWA 186
LLA+ S D++V +W ++ EC+ L GH V+ V + IL S S D +IK+W
Sbjct: 1424 LLASGSDDQTVRLWN---ISSGECLYTLHGHINSVRSVAFSSDGLILASGSDDETIKLW- 1479
Query: 187 DEGDSDDWQCVQTL 200
D +C++TL
Sbjct: 1480 ---DVKTGECIKTL 1490
Score = 81.6 bits (200), Expect = 1e-15
Identities = 48/159 (30%), Positives = 83/159 (52%), Gaps = 13/159 (8%)
Query: 71 TVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTLLAT 130
+V + A+SP GKL AT WE G + + T +GH + V SV ++ G +LA+
Sbjct: 866 SVLTVAFSPDGKLFATGDSGGIVRFWEAATG--KELLTCKGHNSWVNSVGFSQDGKMLAS 923
Query: 131 CSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVWADEGD 190
S D++V +W+ ++ +C+ +GHT V+ V + P +L S S D ++++W D
Sbjct: 924 GSDDQTVRLWD---ISSGQCLKTFKGHTSRVRSVVFSPNSLMLASGSSDQTVRLW----D 976
Query: 191 SDDWQCVQTLGQPNNGHTSTVWALSFNASGDKMVTCSSN 229
+C+ GHT V++++FN G + T S +
Sbjct: 977 ISSGECLYIF----QGHTGWVYSVAFNLDGSMLATGSGD 1011
Score = 80.5 bits (197), Expect = 3e-15
Identities = 53/142 (37%), Positives = 80/142 (56%), Gaps = 16/142 (11%)
Query: 14 GHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDETHTRTVR 73
GH + V S+ ++P + AS SGD+TVR+W +SSG C L + H V
Sbjct: 1366 GHTNWVGSVIFSPDGA------ILASGSGDQTVRLWS--ISSG--KCLYTL-QGHNNWVG 1414
Query: 74 SCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTLLATCSR 133
S +SP G LLA+ S D T +W G EC+ TL GH N V+SV++++ G +LA+ S
Sbjct: 1415 SIVFSPDGTLLASGSDDQTVRLWNISSG--ECLYTLHGHINSVRSVAFSSDGLILASGSD 1472
Query: 134 DKSVWIWEMQPVNEFECVSVLQ 155
D+++ +W+ V EC+ L+
Sbjct: 1473 DETIKLWD---VKTGECIKTLK 1491
>HET1_PODAN (Q00808) Vegetatible incompatibility protein HET-E-1
Length = 1356
Score = 108 bits (269), Expect = 1e-23
Identities = 77/220 (35%), Positives = 111/220 (50%), Gaps = 24/220 (10%)
Query: 10 QRLEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDETHT 69
Q LEGH VWS+ ++P AS S DKT++IW D +SG C L E H
Sbjct: 877 QTLEGHGGSVWSVAFSPDRERV------ASGSDDKTIKIW--DAASG--TCTQTL-EGHG 925
Query: 70 RTVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTLLA 129
V+S A+SP G+ +A+ S D T IW+ G C TLEGH + V SV+++ G +A
Sbjct: 926 GRVQSVAFSPDGQRVASGSDDHTIKIWDAASGT--CTQTLEGHGSSVLSVAFSPDGQRVA 983
Query: 130 TCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVWADEG 189
+ S DK++ IW+ C L+GH V V + P + S S D +IK+W
Sbjct: 984 SGSGDKTIKIWD---TASGTCTQTLEGHGGSVWSVAFSPDGQRVASGSDDKTIKIW---- 1036
Query: 190 DSDDWQCVQTLGQPNNGHTSTVWALSFNASGDKMVTCSSN 229
D+ C QTL GH V ++ F+ G ++ + S +
Sbjct: 1037 DTASGTCTQTL----EGHGGWVQSVVFSPDGQRVASGSDD 1072
Score = 107 bits (267), Expect = 2e-23
Identities = 79/208 (37%), Positives = 108/208 (50%), Gaps = 25/208 (12%)
Query: 10 QRLEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDETHT 69
Q LEGH D VWS+ ++P AS S D T++IW D +SG C L E H
Sbjct: 1087 QTLEGHGDSVWSVAFSPDGQRV------ASGSIDGTIKIW--DAASG--TCTQTL-EGHG 1135
Query: 70 RTVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTLLA 129
V S A+SP G+ +A+ S D T IW+ G C TLEGH V+SV+++ G +A
Sbjct: 1136 GWVHSVAFSPDGQRVASGSIDGTIKIWDAASGT--CTQTLEGHGGWVQSVAFSPDGQRVA 1193
Query: 130 TCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVWADEG 189
+ S DK++ IW+ C L+GH V+ V + P + S S DN+IK+W
Sbjct: 1194 SGSSDKTIKIWD---TASGTCTQTLEGHGGWVQSVAFSPDGQRVASGSSDNTIKIW---- 1246
Query: 190 DSDDWQCVQTLGQPNNGHTSTVWALSFN 217
D+ C QTL N G T+T LSF+
Sbjct: 1247 DTASGTCTQTL---NVGSTAT--CLSFD 1269
Score = 106 bits (265), Expect = 4e-23
Identities = 77/220 (35%), Positives = 112/220 (50%), Gaps = 24/220 (10%)
Query: 10 QRLEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDETHT 69
Q LEGH VWS+ ++P AS S DKT++IW D +SG C L E H
Sbjct: 1003 QTLEGHGGSVWSVAFSPDGQRV------ASGSDDKTIKIW--DTASG--TCTQTL-EGHG 1051
Query: 70 RTVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTLLA 129
V+S +SP G+ +A+ S D T IW+ V G C TLEGH + V SV+++ G +A
Sbjct: 1052 GWVQSVVFSPDGQRVASGSDDHTIKIWDAVSGT--CTQTLEGHGDSVWSVAFSPDGQRVA 1109
Query: 130 TCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVWADEG 189
+ S D ++ IW+ C L+GH V V + P + S S D +IK+W
Sbjct: 1110 SGSIDGTIKIWD---AASGTCTQTLEGHGGWVHSVAFSPDGQRVASGSIDGTIKIW---- 1162
Query: 190 DSDDWQCVQTLGQPNNGHTSTVWALSFNASGDKMVTCSSN 229
D+ C QTL GH V +++F+ G ++ + SS+
Sbjct: 1163 DAASGTCTQTL----EGHGGWVQSVAFSPDGQRVASGSSD 1198
Score = 102 bits (255), Expect = 6e-22
Identities = 72/220 (32%), Positives = 109/220 (48%), Gaps = 24/220 (10%)
Query: 10 QRLEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDETHT 69
Q LEGH V S+ ++ A G AS S DKT++IW+ +G E H
Sbjct: 835 QTLEGHGSSVLSVAFS-ADGQR-----VASGSDDKTIKIWDTASGTGTQTL-----EGHG 883
Query: 70 RTVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTLLA 129
+V S A+SP + +A+ S D T IW+ G C TLEGH V+SV+++ G +A
Sbjct: 884 GSVWSVAFSPDRERVASGSDDKTIKIWDAASG--TCTQTLEGHGGRVQSVAFSPDGQRVA 941
Query: 130 TCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVWADEG 189
+ S D ++ IW+ C L+GH V V + P + S S D +IK+W
Sbjct: 942 SGSDDHTIKIWD---AASGTCTQTLEGHGSSVLSVAFSPDGQRVASGSGDKTIKIW---- 994
Query: 190 DSDDWQCVQTLGQPNNGHTSTVWALSFNASGDKMVTCSSN 229
D+ C QTL GH +VW+++F+ G ++ + S +
Sbjct: 995 DTASGTCTQTL----EGHGGSVWSVAFSPDGQRVASGSDD 1030
Score = 79.7 bits (195), Expect = 5e-15
Identities = 56/171 (32%), Positives = 87/171 (50%), Gaps = 14/171 (8%)
Query: 59 ACKAVLDETHTRTVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKS 118
AC L E H +V S A+S G+ +A+ S D T IW+ G TLEGH V S
Sbjct: 832 ACTQTL-EGHGSSVLSVAFSADGQRVASGSDDKTIKIWDTASG--TGTQTLEGHGGSVWS 888
Query: 119 VSWNASGTLLATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSY 178
V+++ +A+ S DK++ IW+ C L+GH V+ V + P + S S
Sbjct: 889 VAFSPDRERVASGSDDKTIKIWD---AASGTCTQTLEGHGGRVQSVAFSPDGQRVASGSD 945
Query: 179 DNSIKVWADEGDSDDWQCVQTLGQPNNGHTSTVWALSFNASGDKMVTCSSN 229
D++IK+W D+ C QTL GH S+V +++F+ G ++ + S +
Sbjct: 946 DHTIKIW----DAASGTCTQTL----EGHGSSVLSVAFSPDGQRVASGSGD 988
>LIS1_RAT (P63004) Platelet-activating factor acetylhydrolase IB
alpha subunit (PAF acetylhydrolase 45 kDa subunit)
(PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha)
(Lissencephaly-1 protein) (LIS-1)
Length = 409
Score = 98.2 bits (243), Expect = 1e-20
Identities = 57/178 (32%), Positives = 93/178 (52%), Gaps = 16/178 (8%)
Query: 8 EVQRLEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDET 67
E L GH V + ++P V S S D T+++W+ + K
Sbjct: 99 EKYALSGHRSPVTRVIFHPVFS------VMVSASEDATIKVWDYETGDFERTLKG----- 147
Query: 68 HTRTVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTL 127
HT +V+ ++ SGKLLA+ S D T +W+ G FEC+ T+ GH++ V SV+ +G
Sbjct: 148 HTDSVQDISFDHSGKLLASCSADMTIKLWDFQG--FECIRTMHGHDHNVSSVAIMPNGDH 205
Query: 128 LATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVW 185
+ + SRDK++ +WE+Q CV GH + V+MV+ + ++ SCS D +++VW
Sbjct: 206 IVSASRDKTIKMWEVQ---TGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVW 260
Score = 79.7 bits (195), Expect = 5e-15
Identities = 49/170 (28%), Positives = 79/170 (45%), Gaps = 30/170 (17%)
Query: 36 VFASCSGDKTVRIWEQDLSSGLWACKAVLDETHTRTVRSCAWSPS--------------- 80
+ ASCS D+TVR+W CKA L E H V +W+P
Sbjct: 247 LIASCSNDQTVRVWVVATKE----CKAELRE-HEHVVECISWAPESSYSSISEATGSETK 301
Query: 81 -----GKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTLLATCSRDK 135
G L + S D T +W+ G C+ TL GH+N V+ V +++ G + +C+ DK
Sbjct: 302 KSGKPGPFLLSGSRDKTIKMWDVSTG--MCLMTLVGHDNWVRGVLFHSGGKFILSCADDK 359
Query: 136 SVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVW 185
++ +W+ + C+ L H V + +H T +++ S D ++KVW
Sbjct: 360 TLRVWDYK---NKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVW 406
Score = 58.5 bits (140), Expect = 1e-08
Identities = 33/119 (27%), Positives = 66/119 (54%), Gaps = 11/119 (9%)
Query: 109 LEGHENEVKSVSWNASGTLLATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHP 168
L GH + V V ++ +++ + S D ++ +W+ + +FE L+GHT V+ + +
Sbjct: 103 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYE-TGDFE--RTLKGHTDSVQDISFDH 159
Query: 169 TEDILISCSYDNSIKVWADEGDSDDWQCVQTLGQPNNGHTSTVWALSFNASGDKMVTCS 227
+ +L SCS D +IK+W D ++C++T+ +GH V +++ +GD +V+ S
Sbjct: 160 SGKLLASCSADMTIKLW----DFQGFECIRTM----HGHDHNVSSVAIMPNGDHIVSAS 210
Score = 52.4 bits (124), Expect = 9e-07
Identities = 42/144 (29%), Positives = 66/144 (45%), Gaps = 21/144 (14%)
Query: 12 LEGHNDRVWSLDWNP---------ATGH----AGTPLVFA-SCSGDKTVRIWEQDLSSGL 57
L H V + W P ATG +G P F S S DKT+++W D+S+G+
Sbjct: 271 LREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMW--DVSTGM 328
Query: 58 WACKAVLDETHTRTVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVK 117
V H VR + GK + + + D T +W+ C+ TL HE+ V
Sbjct: 329 CLMTLV---GHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNK--RCMKTLNAHEHFVT 383
Query: 118 SVSWNASGTLLATCSRDKSVWIWE 141
S+ ++ + + T S D++V +WE
Sbjct: 384 SLDFHKTAPYVVTGSVDQTVKVWE 407
Score = 50.4 bits (119), Expect = 4e-06
Identities = 42/126 (33%), Positives = 62/126 (48%), Gaps = 19/126 (15%)
Query: 106 VATLEGHENEVKSVSWNASGTLLATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVK 165
V LE NE K + + G L RD WI +P ++ L GH V V
Sbjct: 64 VMELESKLNEAKE-EFTSGGPLGQ--KRDPKEWI--PRPPEKY----ALSGHRSPVTRVI 114
Query: 166 WHPTEDILISCSYDNSIKVWADE-GDSDDWQCVQTLGQPNNGHTSTVWALSFNASGDKMV 224
+HP +++S S D +IKVW E GD + +TL GHT +V +SF+ SG +
Sbjct: 115 FHPVFSVMVSASEDATIKVWDYETGDFE-----RTL----KGHTDSVQDISFDHSGKLLA 165
Query: 225 TCSSNL 230
+CS+++
Sbjct: 166 SCSADM 171
>LIS1_MOUSE (P63005) Platelet-activating factor acetylhydrolase IB
alpha subunit (PAF acetylhydrolase 45 kDa subunit)
(PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha)
(Lissencephaly-1 protein) (LIS-1)
Length = 409
Score = 98.2 bits (243), Expect = 1e-20
Identities = 57/178 (32%), Positives = 93/178 (52%), Gaps = 16/178 (8%)
Query: 8 EVQRLEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDET 67
E L GH V + ++P V S S D T+++W+ + K
Sbjct: 99 EKYALSGHRSPVTRVIFHPVFS------VMVSASEDATIKVWDYETGDFERTLKG----- 147
Query: 68 HTRTVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTL 127
HT +V+ ++ SGKLLA+ S D T +W+ G FEC+ T+ GH++ V SV+ +G
Sbjct: 148 HTDSVQDISFDHSGKLLASCSADMTIKLWDFQG--FECIRTMHGHDHNVSSVAIMPNGDH 205
Query: 128 LATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVW 185
+ + SRDK++ +WE+Q CV GH + V+MV+ + ++ SCS D +++VW
Sbjct: 206 IVSASRDKTIKMWEVQ---TGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVW 260
Score = 79.7 bits (195), Expect = 5e-15
Identities = 49/170 (28%), Positives = 79/170 (45%), Gaps = 30/170 (17%)
Query: 36 VFASCSGDKTVRIWEQDLSSGLWACKAVLDETHTRTVRSCAWSPS--------------- 80
+ ASCS D+TVR+W CKA L E H V +W+P
Sbjct: 247 LIASCSNDQTVRVWVVATKE----CKAELRE-HEHVVECISWAPESSYSSISEATGSETK 301
Query: 81 -----GKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTLLATCSRDK 135
G L + S D T +W+ G C+ TL GH+N V+ V +++ G + +C+ DK
Sbjct: 302 KSGKPGPFLLSGSRDKTIKMWDVSTG--MCLMTLVGHDNWVRGVLFHSGGKFILSCADDK 359
Query: 136 SVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVW 185
++ +W+ + C+ L H V + +H T +++ S D ++KVW
Sbjct: 360 TLRVWDYK---NKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVW 406
Score = 58.5 bits (140), Expect = 1e-08
Identities = 33/119 (27%), Positives = 66/119 (54%), Gaps = 11/119 (9%)
Query: 109 LEGHENEVKSVSWNASGTLLATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHP 168
L GH + V V ++ +++ + S D ++ +W+ + +FE L+GHT V+ + +
Sbjct: 103 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYE-TGDFE--RTLKGHTDSVQDISFDH 159
Query: 169 TEDILISCSYDNSIKVWADEGDSDDWQCVQTLGQPNNGHTSTVWALSFNASGDKMVTCS 227
+ +L SCS D +IK+W D ++C++T+ +GH V +++ +GD +V+ S
Sbjct: 160 SGKLLASCSADMTIKLW----DFQGFECIRTM----HGHDHNVSSVAIMPNGDHIVSAS 210
Score = 52.4 bits (124), Expect = 9e-07
Identities = 42/144 (29%), Positives = 66/144 (45%), Gaps = 21/144 (14%)
Query: 12 LEGHNDRVWSLDWNP---------ATGH----AGTPLVFA-SCSGDKTVRIWEQDLSSGL 57
L H V + W P ATG +G P F S S DKT+++W D+S+G+
Sbjct: 271 LREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMW--DVSTGM 328
Query: 58 WACKAVLDETHTRTVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVK 117
V H VR + GK + + + D T +W+ C+ TL HE+ V
Sbjct: 329 CLMTLV---GHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNK--RCMKTLNAHEHFVT 383
Query: 118 SVSWNASGTLLATCSRDKSVWIWE 141
S+ ++ + + T S D++V +WE
Sbjct: 384 SLDFHKTAPYVVTGSVDQTVKVWE 407
Score = 50.4 bits (119), Expect = 4e-06
Identities = 42/126 (33%), Positives = 62/126 (48%), Gaps = 19/126 (15%)
Query: 106 VATLEGHENEVKSVSWNASGTLLATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVK 165
V LE NE K + + G L RD WI +P ++ L GH V V
Sbjct: 64 VMELESKLNEAKE-EFTSGGPLGQ--KRDPKEWI--PRPPEKY----ALSGHRSPVTRVI 114
Query: 166 WHPTEDILISCSYDNSIKVWADE-GDSDDWQCVQTLGQPNNGHTSTVWALSFNASGDKMV 224
+HP +++S S D +IKVW E GD + +TL GHT +V +SF+ SG +
Sbjct: 115 FHPVFSVMVSASEDATIKVWDYETGDFE-----RTL----KGHTDSVQDISFDHSGKLLA 165
Query: 225 TCSSNL 230
+CS+++
Sbjct: 166 SCSADM 171
>LIS1_HUMAN (P43034) Platelet-activating factor acetylhydrolase IB
alpha subunit (PAF acetylhydrolase 45 kDa subunit)
(PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha)
(Lissencephaly-1 protein) (LIS-1)
Length = 409
Score = 98.2 bits (243), Expect = 1e-20
Identities = 57/178 (32%), Positives = 93/178 (52%), Gaps = 16/178 (8%)
Query: 8 EVQRLEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDET 67
E L GH V + ++P V S S D T+++W+ + K
Sbjct: 99 EKYALSGHRSPVTRVIFHPVFS------VMVSASEDATIKVWDYETGDFERTLKG----- 147
Query: 68 HTRTVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTL 127
HT +V+ ++ SGKLLA+ S D T +W+ G FEC+ T+ GH++ V SV+ +G
Sbjct: 148 HTDSVQDISFDHSGKLLASCSADMTIKLWDFQG--FECIRTMHGHDHNVSSVAIMPNGDH 205
Query: 128 LATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVW 185
+ + SRDK++ +WE+Q CV GH + V+MV+ + ++ SCS D +++VW
Sbjct: 206 IVSASRDKTIKMWEVQ---TGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVW 260
Score = 79.7 bits (195), Expect = 5e-15
Identities = 49/170 (28%), Positives = 79/170 (45%), Gaps = 30/170 (17%)
Query: 36 VFASCSGDKTVRIWEQDLSSGLWACKAVLDETHTRTVRSCAWSPS--------------- 80
+ ASCS D+TVR+W CKA L E H V +W+P
Sbjct: 247 LIASCSNDQTVRVWVVATKE----CKAELRE-HEHVVECISWAPESSYSSISEATGSETK 301
Query: 81 -----GKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTLLATCSRDK 135
G L + S D T +W+ G C+ TL GH+N V+ V +++ G + +C+ DK
Sbjct: 302 KSGKPGPFLLSGSRDKTIKMWDVSTG--MCLMTLVGHDNWVRGVLFHSGGKFILSCADDK 359
Query: 136 SVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVW 185
++ +W+ + C+ L H V + +H T +++ S D ++KVW
Sbjct: 360 TLRVWDYK---NKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVW 406
Score = 58.5 bits (140), Expect = 1e-08
Identities = 33/119 (27%), Positives = 66/119 (54%), Gaps = 11/119 (9%)
Query: 109 LEGHENEVKSVSWNASGTLLATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHP 168
L GH + V V ++ +++ + S D ++ +W+ + +FE L+GHT V+ + +
Sbjct: 103 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYE-TGDFE--RTLKGHTDSVQDISFDH 159
Query: 169 TEDILISCSYDNSIKVWADEGDSDDWQCVQTLGQPNNGHTSTVWALSFNASGDKMVTCS 227
+ +L SCS D +IK+W D ++C++T+ +GH V +++ +GD +V+ S
Sbjct: 160 SGKLLASCSADMTIKLW----DFQGFECIRTM----HGHDHNVSSVAIMPNGDHIVSAS 210
Score = 52.4 bits (124), Expect = 9e-07
Identities = 42/144 (29%), Positives = 66/144 (45%), Gaps = 21/144 (14%)
Query: 12 LEGHNDRVWSLDWNP---------ATGH----AGTPLVFA-SCSGDKTVRIWEQDLSSGL 57
L H V + W P ATG +G P F S S DKT+++W D+S+G+
Sbjct: 271 LREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMW--DVSTGM 328
Query: 58 WACKAVLDETHTRTVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVK 117
V H VR + GK + + + D T +W+ C+ TL HE+ V
Sbjct: 329 CLMTLV---GHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNK--RCMKTLNAHEHFVT 383
Query: 118 SVSWNASGTLLATCSRDKSVWIWE 141
S+ ++ + + T S D++V +WE
Sbjct: 384 SLDFHKTAPYVVTGSVDQTVKVWE 407
Score = 50.4 bits (119), Expect = 4e-06
Identities = 42/126 (33%), Positives = 62/126 (48%), Gaps = 19/126 (15%)
Query: 106 VATLEGHENEVKSVSWNASGTLLATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVK 165
V LE NE K + + G L RD WI +P ++ L GH V V
Sbjct: 64 VMELESKLNEAKE-EFTSGGPLGQ--KRDPKEWI--PRPPEKY----ALSGHRSPVTRVI 114
Query: 166 WHPTEDILISCSYDNSIKVWADE-GDSDDWQCVQTLGQPNNGHTSTVWALSFNASGDKMV 224
+HP +++S S D +IKVW E GD + +TL GHT +V +SF+ SG +
Sbjct: 115 FHPVFSVMVSASEDATIKVWDYETGDFE-----RTL----KGHTDSVQDISFDHSGKLLA 165
Query: 225 TCSSNL 230
+CS+++
Sbjct: 166 SCSADM 171
>LIS1_BOVIN (P43033) Platelet-activating factor acetylhydrolase IB
alpha subunit (PAF acetylhydrolase 45 kDa subunit)
(PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha)
(Lissencephaly-1 protein) (LIS-1)
Length = 409
Score = 97.8 bits (242), Expect = 2e-20
Identities = 57/178 (32%), Positives = 92/178 (51%), Gaps = 16/178 (8%)
Query: 8 EVQRLEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDET 67
E L GH V + ++P V S S D T+++W+ + K
Sbjct: 99 EKYALSGHRSPVTRVIFHPVFS------VMVSASEDATIKVWDYETGDFERTLKG----- 147
Query: 68 HTRTVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTL 127
HT +V ++ SGKLLA+ S D T +W+ G FEC+ T+ GH++ V SV+ +G
Sbjct: 148 HTDSVEDISFDHSGKLLASCSADMTIKLWDFQG--FECIRTMHGHDHNVSSVAIMPNGDH 205
Query: 128 LATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVW 185
+ + SRDK++ +WE+Q CV GH + V+MV+ + ++ SCS D +++VW
Sbjct: 206 IVSASRDKTIKMWEVQ---TGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVW 260
Score = 79.7 bits (195), Expect = 5e-15
Identities = 49/170 (28%), Positives = 79/170 (45%), Gaps = 30/170 (17%)
Query: 36 VFASCSGDKTVRIWEQDLSSGLWACKAVLDETHTRTVRSCAWSPS--------------- 80
+ ASCS D+TVR+W CKA L E H V +W+P
Sbjct: 247 LIASCSNDQTVRVWVVATKE----CKAELRE-HEHVVECISWAPESSYSSISEATGSETK 301
Query: 81 -----GKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTLLATCSRDK 135
G L + S D T +W+ G C+ TL GH+N V+ V +++ G + +C+ DK
Sbjct: 302 KSGKPGPFLLSGSRDKTIKMWDVSTG--MCLMTLVGHDNWVRGVLFHSGGKFILSCADDK 359
Query: 136 SVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVW 185
++ +W+ + C+ L H V + +H T +++ S D ++KVW
Sbjct: 360 TLRVWDYK---NKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVW 406
Score = 58.5 bits (140), Expect = 1e-08
Identities = 33/119 (27%), Positives = 66/119 (54%), Gaps = 11/119 (9%)
Query: 109 LEGHENEVKSVSWNASGTLLATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHP 168
L GH + V V ++ +++ + S D ++ +W+ + +FE L+GHT V+ + +
Sbjct: 103 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYE-TGDFE--RTLKGHTDSVEDISFDH 159
Query: 169 TEDILISCSYDNSIKVWADEGDSDDWQCVQTLGQPNNGHTSTVWALSFNASGDKMVTCS 227
+ +L SCS D +IK+W D ++C++T+ +GH V +++ +GD +V+ S
Sbjct: 160 SGKLLASCSADMTIKLW----DFQGFECIRTM----HGHDHNVSSVAIMPNGDHIVSAS 210
Score = 52.4 bits (124), Expect = 9e-07
Identities = 42/144 (29%), Positives = 66/144 (45%), Gaps = 21/144 (14%)
Query: 12 LEGHNDRVWSLDWNP---------ATGH----AGTPLVFA-SCSGDKTVRIWEQDLSSGL 57
L H V + W P ATG +G P F S S DKT+++W D+S+G+
Sbjct: 271 LREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMW--DVSTGM 328
Query: 58 WACKAVLDETHTRTVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVK 117
V H VR + GK + + + D T +W+ C+ TL HE+ V
Sbjct: 329 CLMTLV---GHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNK--RCMKTLNAHEHFVT 383
Query: 118 SVSWNASGTLLATCSRDKSVWIWE 141
S+ ++ + + T S D++V +WE
Sbjct: 384 SLDFHKTAPYVVTGSVDQTVKVWE 407
Score = 50.1 bits (118), Expect = 5e-06
Identities = 42/126 (33%), Positives = 62/126 (48%), Gaps = 19/126 (15%)
Query: 106 VATLEGHENEVKSVSWNASGTLLATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVK 165
V LE NE K + + G L RD WI +P ++ L GH V V
Sbjct: 64 VMELESKLNEAKE-EFTSGGPLGQ--KRDPKEWI--PRPPEKY----ALSGHRSPVTRVI 114
Query: 166 WHPTEDILISCSYDNSIKVWADE-GDSDDWQCVQTLGQPNNGHTSTVWALSFNASGDKMV 224
+HP +++S S D +IKVW E GD + +TL GHT +V +SF+ SG +
Sbjct: 115 FHPVFSVMVSASEDATIKVWDYETGDFE-----RTL----KGHTDSVEDISFDHSGKLLA 165
Query: 225 TCSSNL 230
+CS+++
Sbjct: 166 SCSADM 171
>YL24_ANASP (Q8YV57) Hypothetical WD-repeat protein all2124
Length = 1683
Score = 94.4 bits (233), Expect = 2e-19
Identities = 77/293 (26%), Positives = 129/293 (43%), Gaps = 83/293 (28%)
Query: 7 KEVQRLEGHNDRVWSLD-------------------WN-------PATGHAGTPL----- 35
K V+ L+GHND VW ++ WN TGH+G
Sbjct: 1272 KLVKTLKGHNDSVWDVNFSSDGKAIASASRDNTIKLWNRHGIELETFTGHSGGVYAVNFL 1331
Query: 36 ----VFASCSGDKTVRIWEQDL---------SSGLWACKAVLDETHTRT----------- 71
+ AS S D T+R+W++ L +SG++A + D + T
Sbjct: 1332 PDSNIIASASLDNTIRLWQRPLISPLEVLAGNSGVYAVSFLHDGSIIATAGADGNIQLWH 1391
Query: 72 ---------------VRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEV 116
+ +++P G L+A+A+ D T IW G + + TL GH+NEV
Sbjct: 1392 SQDGSLLKTLPGNKAIYGISFTPQGDLIASANADKTVKIWRVRDG--KALKTLIGHDNEV 1449
Query: 117 KSVSWNASGTLLATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISC 176
V+++ G LA+ SRD +V +W V++ + L+GHT +V V + P I+ S
Sbjct: 1450 NKVNFSPDGKTLASASRDNTVKLWN---VSDGKFKKTLKGHTDEVFWVSFSPDGKIIASA 1506
Query: 177 SYDNSIKVWADEGDSDDWQCVQTLGQPNNGHTSTVWALSFNASGDKMVTCSSN 229
S D +I++W DS +++L H V++++FN G + + S++
Sbjct: 1507 SADKTIRLW----DSFSGNLIKSL----PAHNDLVYSVNFNPDGSMLASTSAD 1551
Score = 90.5 bits (223), Expect = 3e-18
Identities = 76/259 (29%), Positives = 119/259 (45%), Gaps = 55/259 (21%)
Query: 5 ELKEVQRLEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQD------------ 52
E++E RLEGH D V S+ + G + AS S DKT+++W +D
Sbjct: 1061 EMQERNRLEGHKDGVISI----SISRDGQTI--ASGSLDKTIKLWSRDGRLFRTLNGHED 1114
Query: 53 -------------LSSG-------LW-ACKAVLDET---HTRTVRSCAWSPSGKLLATAS 88
++SG LW L +T H +TV + +SP GK LA+AS
Sbjct: 1115 AVYSVSFSPDGQTIASGGSDKTIKLWQTSDGTLLKTITGHEQTVNNVYFSPDGKNLASAS 1174
Query: 89 FDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTLLATCSRDKSVWIWEMQPVNEF 148
D + +W+ G + + TL GH V +V ++ G +A S DK+V +W Q +
Sbjct: 1175 SDHSIKLWDTTSG--QLLMTLTGHSAGVITVRFSPDGQTIAAGSEDKTVKLWHRQ---DG 1229
Query: 149 ECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVWADEGDSDDWQCVQTLGQPNNGHT 208
+ + L GH V + + P L S S D +IK+W D + V+TL GH
Sbjct: 1230 KLLKTLNGHQDWVNSLSFSPDGKTLASASADKTIKLWR----IADGKLVKTL----KGHN 1281
Query: 209 STVWALSFNASGDKMVTCS 227
+VW ++F++ G + + S
Sbjct: 1282 DSVWDVNFSSDGKAIASAS 1300
Score = 89.0 bits (219), Expect = 9e-18
Identities = 61/194 (31%), Positives = 98/194 (50%), Gaps = 18/194 (9%)
Query: 36 VFASCSGDKTVRIWEQDLSSGLWACKAVLDETHTRTVRSCAWSPSGKLLATASFDATTAI 95
+ AS + DKTV+IW L K ++ H V +SP GK LA+AS D T +
Sbjct: 1418 LIASANADKTVKIWRVRDGKAL---KTLIG--HDNEVNKVNFSPDGKTLASASRDNTVKL 1472
Query: 96 WENVGGDFECVATLEGHENEVKSVSWNASGTLLATCSRDKSVWIWEMQPVNEFECVSVLQ 155
W G F+ TL+GH +EV VS++ G ++A+ S DK++ +W+ N + L
Sbjct: 1473 WNVSDGKFK--KTLKGHTDEVFWVSFSPDGKIIASASADKTIRLWDSFSGN---LIKSLP 1527
Query: 156 GHTQDVKMVKWHPTEDILISCSYDNSIKVWADEGDSDDWQCVQTLGQPNNGHTSTVWALS 215
H V V ++P +L S S D ++K+W S D + T +GH++ V++ S
Sbjct: 1528 AHNDLVYSVNFNPDGSMLASTSADKTVKLWR----SHDGHLLHTF----SGHSNVVYSSS 1579
Query: 216 FNASGDKMVTCSSN 229
F+ G + + S +
Sbjct: 1580 FSPDGRYIASASED 1593
Score = 85.1 bits (209), Expect = 1e-16
Identities = 65/221 (29%), Positives = 115/221 (51%), Gaps = 25/221 (11%)
Query: 7 KEVQRLEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDE 66
K ++ L GH++ V ++++P G L AS S D TV++W ++S G + K L +
Sbjct: 1437 KALKTLIGHDNEVNKVNFSPD----GKTL--ASASRDNTVKLW--NVSDGKF--KKTL-K 1485
Query: 67 THTRTVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGT 126
HT V ++SP GK++A+AS D T +W++ G+ + +L H + V SV++N G+
Sbjct: 1486 GHTDEVFWVSFSPDGKIIASASADKTIRLWDSFSGNL--IKSLPAHNDLVYSVNFNPDGS 1543
Query: 127 LLATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVWA 186
+LA+ S DK+V +W ++ + GH+ V + P + S S D ++K+W
Sbjct: 1544 MLASTSADKTVKLWRS---HDGHLLHTFSGHSNVVYSSSFSPDGRYIASASEDKTVKIWQ 1600
Query: 187 DEGDSDDWQCVQTLGQPNNGHTSTVWALSFNASGDKMVTCS 227
+G + TL Q H + V + F+ G +++ S
Sbjct: 1601 IDG-----HLLTTLPQ----HQAGVMSAIFSPDGKTLISGS 1632
Score = 82.8 bits (203), Expect = 6e-16
Identities = 53/174 (30%), Positives = 87/174 (49%), Gaps = 17/174 (9%)
Query: 12 LEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDETHTRT 71
L GH+ V ++ ++P A+ S DKTV++W + L H
Sbjct: 1193 LTGHSAGVITVRFSP------DGQTIAAGSEDKTVKLWHRQDGKLLKTLNG-----HQDW 1241
Query: 72 VRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTLLATC 131
V S ++SP GK LA+AS D T +W G + V TL+GH + V V++++ G +A+
Sbjct: 1242 VNSLSFSPDGKTLASASADKTIKLWRIADG--KLVKTLKGHNDSVWDVNFSSDGKAIASA 1299
Query: 132 SRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVW 185
SRD ++ +W + + GH+ V V + P +I+ S S DN+I++W
Sbjct: 1300 SRDNTIKLWNRHGIE----LETFTGHSGGVYAVNFLPDSNIIASASLDNTIRLW 1349
Score = 81.6 bits (200), Expect = 1e-15
Identities = 53/174 (30%), Positives = 85/174 (48%), Gaps = 17/174 (9%)
Query: 12 LEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDETHTRT 71
L+GH D V+ + ++P + AS S DKT+R+W+ + + + A H
Sbjct: 1484 LKGHTDEVFWVSFSP------DGKIIASASADKTIRLWDSFSGNLIKSLPA-----HNDL 1532
Query: 72 VRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTLLATC 131
V S ++P G +LA+ S D T +W + G + T GH N V S S++ G +A+
Sbjct: 1533 VYSVNFNPDGSMLASTSADKTVKLWRSHDGHL--LHTFSGHSNVVYSSSFSPDGRYIASA 1590
Query: 132 SRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVW 185
S DK+V IW++ + ++ L H V + P LIS S D + K+W
Sbjct: 1591 SEDKTVKIWQI----DGHLLTTLPQHQAGVMSAIFSPDGKTLISGSLDTTTKIW 1640
Score = 79.3 bits (194), Expect = 7e-15
Identities = 63/245 (25%), Positives = 104/245 (41%), Gaps = 63/245 (25%)
Query: 12 LEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDETHTRT 71
L GH D V+S+ ++P AS DKT+++W+ + L H +T
Sbjct: 1109 LNGHEDAVYSVSFSP------DGQTIASGGSDKTIKLWQTSDGTLLKTITG-----HEQT 1157
Query: 72 VRSCAWSPSGKLLATASFDATTAIWENVGG------------------------------ 101
V + +SP GK LA+AS D + +W+ G
Sbjct: 1158 VNNVYFSPDGKNLASASSDHSIKLWDTTSGQLLMTLTGHSAGVITVRFSPDGQTIAAGSE 1217
Query: 102 ----------DFECVATLEGHENEVKSVSWNASGTLLATCSRDKSVWIWEMQPVNEFECV 151
D + + TL GH++ V S+S++ G LA+ S DK++ +W + + + V
Sbjct: 1218 DKTVKLWHRQDGKLLKTLNGHQDWVNSLSFSPDGKTLASASADKTIKLWR---IADGKLV 1274
Query: 152 SVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVWADEGDSDDWQCVQTLGQPNNGHTSTV 211
L+GH V V + + S S DN+IK+W G ++T GH+ V
Sbjct: 1275 KTLKGHNDSVWDVNFSSDGKAIASASRDNTIKLWNRHGIE-----LETF----TGHSGGV 1325
Query: 212 WALSF 216
+A++F
Sbjct: 1326 YAVNF 1330
Score = 73.6 bits (179), Expect = 4e-13
Identities = 51/164 (31%), Positives = 80/164 (48%), Gaps = 14/164 (8%)
Query: 66 ETHTRTVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASG 125
E H V S + S G+ +A+ S D T +W G F TL GHE+ V SVS++ G
Sbjct: 1069 EGHKDGVISISISRDGQTIASGSLDKTIKLWSRDGRLFR---TLNGHEDAVYSVSFSPDG 1125
Query: 126 TLLATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVW 185
+A+ DK++ +W+ ++ + + GH Q V V + P L S S D+SIK+W
Sbjct: 1126 QTIASGGSDKTIKLWQ---TSDGTLLKTITGHEQTVNNVYFSPDGKNLASASSDHSIKLW 1182
Query: 186 ADEGDSDDWQCVQTLGQPNNGHTSTVWALSFNASGDKMVTCSSN 229
D+ Q + TL GH++ V + F+ G + S +
Sbjct: 1183 ----DTTSGQLLMTL----TGHSAGVITVRFSPDGQTIAAGSED 1218
Score = 70.9 bits (172), Expect = 3e-12
Identities = 62/227 (27%), Positives = 107/227 (46%), Gaps = 27/227 (11%)
Query: 3 RLELKEVQRLEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKA 62
R + K ++ L GH D V SL ++P G L AS S DKT+++W + K
Sbjct: 1226 RQDGKLLKTLNGHQDWVNSLSFSPD----GKTL--ASASADKTIKLWRIADGKLVKTLKG 1279
Query: 63 VLDETHTRTVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWN 122
H +V +S GK +A+AS D T +W G + E T GH V +V++
Sbjct: 1280 -----HNDSVWDVNFSSDGKAIASASRDNTIKLWNRHGIELE---TFTGHSGGVYAVNFL 1331
Query: 123 ASGTLLATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSI 182
++A+ S D ++ +W+ ++ E VL G++ V V + I+ + D +I
Sbjct: 1332 PDSNIIASASLDNTIRLWQRPLISPLE---VLAGNS-GVYAVSFLHDGSIIATAGADGNI 1387
Query: 183 KVWADEGDSDDWQCVQTLGQPNNGHTSTVWALSFNASGDKMVTCSSN 229
++W S D ++TL P N ++ +SF GD + + +++
Sbjct: 1388 QLW----HSQDGSLLKTL--PGN---KAIYGISFTPQGDLIASANAD 1425
Score = 50.4 bits (119), Expect = 4e-06
Identities = 34/121 (28%), Positives = 57/121 (47%), Gaps = 12/121 (9%)
Query: 109 LEGHENEVKSVSWNASGTLLATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHP 168
LEGH++ V S+S + G +A+ S DK++ +W + L GH V V + P
Sbjct: 1068 LEGHKDGVISISISRDGQTIASGSLDKTIKLWS----RDGRLFRTLNGHEDAVYSVSFSP 1123
Query: 169 TEDILISCSYDNSIKVWADEGDSDDWQCVQTLGQPNNGHTSTVWALSFNASGDKMVTCSS 228
+ S D +IK+W + D ++T+ GH TV + F+ G + + SS
Sbjct: 1124 DGQTIASGGSDKTIKLW----QTSDGTLLKTI----TGHEQTVNNVYFSPDGKNLASASS 1175
Query: 229 N 229
+
Sbjct: 1176 D 1176
>WDR5_MOUSE (P61965) WD-repeat protein 5 (WD-repeat protein BIG-3)
Length = 334
Score = 94.4 bits (233), Expect = 2e-19
Identities = 52/160 (32%), Positives = 90/160 (55%), Gaps = 13/160 (8%)
Query: 68 HTRTVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTL 127
HT+ V S +SP+G+ LA++S D IW G FE T+ GH+ + V+W++ L
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE--KTISGHKLGISDVAWSSDSNL 101
Query: 128 LATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVWAD 187
L + S DK++ IW+ V+ +C+ L+GH+ V ++P ++++S S+D S+++W
Sbjct: 102 LVSASDDKTLKIWD---VSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW-- 156
Query: 188 EGDSDDWQCVQTLGQPNNGHTSTVWALSFNASGDKMVTCS 227
D +C++TL H+ V A+ FN G +V+ S
Sbjct: 157 --DVKTGKCLKTL----PAHSDPVSAVHFNRDGSLIVSSS 190
Score = 86.3 bits (212), Expect = 6e-17
Identities = 62/203 (30%), Positives = 95/203 (46%), Gaps = 26/203 (12%)
Query: 12 LEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDET---H 68
L GH V S+ ++P AS S DK ++IW A ++T H
Sbjct: 41 LAGHTKAVSSVKFSPNGEW------LASSSADKLIKIW--------GAYDGKFEKTISGH 86
Query: 69 TRTVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTLL 128
+ AWS LL +AS D T IW+ G +C+ TL+GH N V ++N L+
Sbjct: 87 KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSG--KCLKTLKGHSNYVFCCNFNPQSNLI 144
Query: 129 ATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVWADE 188
+ S D+SV IW+ V +C+ L H+ V V ++ +++S SYD ++W
Sbjct: 145 VSGSFDESVRIWD---VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW--- 198
Query: 189 GDSDDWQCVQTLGQPNNGHTSTV 211
D+ QC++TL +N S V
Sbjct: 199 -DTASGQCLKTLIDDDNPPVSFV 220
Score = 84.0 bits (206), Expect = 3e-16
Identities = 61/218 (27%), Positives = 106/218 (47%), Gaps = 31/218 (14%)
Query: 14 GHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDETHTRTVR 73
G +D WS D N + S S DKT++IW D+SSG C L + H+ V
Sbjct: 89 GISDVAWSSDSN----------LLVSASDDKTLKIW--DVSSG--KCLKTL-KGHSNYVF 133
Query: 74 SCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTLLATCSR 133
C ++P L+ + SFD + IW+ G +C+ TL H + V +V +N G+L+ + S
Sbjct: 134 CCNFNPQSNLIVSGSFDESVRIWDVKTG--KCLKTLPAHSDPVSAVHFNRDGSLIVSSSY 191
Query: 134 DKSVWIWEMQPVNEFECV-SVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVWADEGDSD 192
D IW+ +C+ +++ V VK+ P +++ + DN++K+W D
Sbjct: 192 DGLCRIWD---TASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW----DYS 244
Query: 193 DWQCVQTLGQPNNGHTSTVWAL--SFNASGDKMVTCSS 228
+C++T GH + + + +F+ +G K + S
Sbjct: 245 KGKCLKTY----TGHKNEKYCIFANFSVTGGKWIVSGS 278
Score = 78.6 bits (192), Expect = 1e-14
Identities = 62/187 (33%), Positives = 93/187 (49%), Gaps = 20/187 (10%)
Query: 7 KEVQRLEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDE 66
K ++ L H+D V ++ +N G+ +V S S D RIW D +SG C L +
Sbjct: 162 KCLKTLPAHSDPVSAVHFN----RDGSLIV--SSSYDGLCRIW--DTASG--QCLKTLID 211
Query: 67 THTRTVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNAS-- 124
V +SP+GK + A+ D T +W+ G +C+ T GH+NE + N S
Sbjct: 212 DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKG--KCLKTYTGHKNEKYCIFANFSVT 269
Query: 125 -GTLLATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDN--S 181
G + + S D V+IW +Q E V LQGHT V HPTE+I+ S + +N +
Sbjct: 270 GGKWIVSGSEDNLVYIWNLQTK---EIVQKLQGHTDVVISTACHPTENIIASAALENDKT 326
Query: 182 IKVWADE 188
IK+W +
Sbjct: 327 IKLWKSD 333
Score = 63.2 bits (152), Expect = 5e-10
Identities = 43/142 (30%), Positives = 70/142 (49%), Gaps = 11/142 (7%)
Query: 86 TASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTLLATCSRDKSVWIWEMQPV 145
T S AT + V ++ TL GH V SV ++ +G LA+ S DK + IW
Sbjct: 18 TPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYD- 76
Query: 146 NEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVWADEGDSDDWQCVQTLGQPNN 205
+FE + GH + V W ++L+S S D ++K+W D +C++TL
Sbjct: 77 GKFE--KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIW----DVSSGKCLKTL----K 126
Query: 206 GHTSTVWALSFNASGDKMVTCS 227
GH++ V+ +FN + +V+ S
Sbjct: 127 GHSNYVFCCNFNPQSNLIVSGS 148
>WDR5_HUMAN (P61964) WD-repeat protein 5
Length = 334
Score = 94.4 bits (233), Expect = 2e-19
Identities = 52/160 (32%), Positives = 90/160 (55%), Gaps = 13/160 (8%)
Query: 68 HTRTVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTL 127
HT+ V S +SP+G+ LA++S D IW G FE T+ GH+ + V+W++ L
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE--KTISGHKLGISDVAWSSDSNL 101
Query: 128 LATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVWAD 187
L + S DK++ IW+ V+ +C+ L+GH+ V ++P ++++S S+D S+++W
Sbjct: 102 LVSASDDKTLKIWD---VSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW-- 156
Query: 188 EGDSDDWQCVQTLGQPNNGHTSTVWALSFNASGDKMVTCS 227
D +C++TL H+ V A+ FN G +V+ S
Sbjct: 157 --DVKTGKCLKTL----PAHSDPVSAVHFNRDGSLIVSSS 190
Score = 86.3 bits (212), Expect = 6e-17
Identities = 62/203 (30%), Positives = 95/203 (46%), Gaps = 26/203 (12%)
Query: 12 LEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDET---H 68
L GH V S+ ++P AS S DK ++IW A ++T H
Sbjct: 41 LAGHTKAVSSVKFSPNGEW------LASSSADKLIKIW--------GAYDGKFEKTISGH 86
Query: 69 TRTVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTLL 128
+ AWS LL +AS D T IW+ G +C+ TL+GH N V ++N L+
Sbjct: 87 KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSG--KCLKTLKGHSNYVFCCNFNPQSNLI 144
Query: 129 ATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVWADE 188
+ S D+SV IW+ V +C+ L H+ V V ++ +++S SYD ++W
Sbjct: 145 VSGSFDESVRIWD---VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW--- 198
Query: 189 GDSDDWQCVQTLGQPNNGHTSTV 211
D+ QC++TL +N S V
Sbjct: 199 -DTASGQCLKTLIDDDNPPVSFV 220
Score = 84.0 bits (206), Expect = 3e-16
Identities = 61/218 (27%), Positives = 106/218 (47%), Gaps = 31/218 (14%)
Query: 14 GHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDETHTRTVR 73
G +D WS D N + S S DKT++IW D+SSG C L + H+ V
Sbjct: 89 GISDVAWSSDSN----------LLVSASDDKTLKIW--DVSSG--KCLKTL-KGHSNYVF 133
Query: 74 SCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTLLATCSR 133
C ++P L+ + SFD + IW+ G +C+ TL H + V +V +N G+L+ + S
Sbjct: 134 CCNFNPQSNLIVSGSFDESVRIWDVKTG--KCLKTLPAHSDPVSAVHFNRDGSLIVSSSY 191
Query: 134 DKSVWIWEMQPVNEFECV-SVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVWADEGDSD 192
D IW+ +C+ +++ V VK+ P +++ + DN++K+W D
Sbjct: 192 DGLCRIWD---TASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW----DYS 244
Query: 193 DWQCVQTLGQPNNGHTSTVWAL--SFNASGDKMVTCSS 228
+C++T GH + + + +F+ +G K + S
Sbjct: 245 KGKCLKTY----TGHKNEKYCIFANFSVTGGKWIVSGS 278
Score = 78.6 bits (192), Expect = 1e-14
Identities = 62/187 (33%), Positives = 93/187 (49%), Gaps = 20/187 (10%)
Query: 7 KEVQRLEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDE 66
K ++ L H+D V ++ +N G+ +V S S D RIW D +SG C L +
Sbjct: 162 KCLKTLPAHSDPVSAVHFN----RDGSLIV--SSSYDGLCRIW--DTASG--QCLKTLID 211
Query: 67 THTRTVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNAS-- 124
V +SP+GK + A+ D T +W+ G +C+ T GH+NE + N S
Sbjct: 212 DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKG--KCLKTYTGHKNEKYCIFANFSVT 269
Query: 125 -GTLLATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDN--S 181
G + + S D V+IW +Q E V LQGHT V HPTE+I+ S + +N +
Sbjct: 270 GGKWIVSGSEDNLVYIWNLQTK---EIVQKLQGHTDVVISTACHPTENIIASAALENDKT 326
Query: 182 IKVWADE 188
IK+W +
Sbjct: 327 IKLWKSD 333
Score = 63.2 bits (152), Expect = 5e-10
Identities = 43/142 (30%), Positives = 70/142 (49%), Gaps = 11/142 (7%)
Query: 86 TASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTLLATCSRDKSVWIWEMQPV 145
T S AT + V ++ TL GH V SV ++ +G LA+ S DK + IW
Sbjct: 18 TPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYD- 76
Query: 146 NEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVWADEGDSDDWQCVQTLGQPNN 205
+FE + GH + V W ++L+S S D ++K+W D +C++TL
Sbjct: 77 GKFE--KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIW----DVSSGKCLKTL----K 126
Query: 206 GHTSTVWALSFNASGDKMVTCS 227
GH++ V+ +FN + +V+ S
Sbjct: 127 GHSNYVFCCNFNPQSNLIVSGS 148
>PRP4_HUMAN (O43172) U4/U6 small nuclear ribonucleoprotein Prp4
(U4/U6 snRNP 60 kDa protein) (WD splicing factor Prp4)
(hPrp4)
Length = 522
Score = 91.7 bits (226), Expect = 1e-18
Identities = 61/220 (27%), Positives = 103/220 (46%), Gaps = 25/220 (11%)
Query: 9 VQRLEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDETH 68
V +EGH RV + W+P+ GT D++ R+W+ + + + E H
Sbjct: 316 VADIEGHTVRVARVMWHPSGRFLGTTCY------DRSWRLWDLEAQEEI-----LHQEGH 364
Query: 69 TRTVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTLL 128
+ V A+ G L T DA +W+ G C+ LEGH E+ ++++ +G +
Sbjct: 365 SMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTG--RCIMFLEGHLKEIYGINFSPNGYHI 422
Query: 129 ATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTE-DILISCSYDNSIKVWAD 187
AT S D + +W+++ + CV + H V VK+ P + L++ +YDN+ K+W
Sbjct: 423 ATGSGDNTCKVWDLR---QRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTH 479
Query: 188 EGDSDDWQCVQTLGQPNNGHTSTVWALSFNASGDKMVTCS 227
G W ++TL GH V L ++ G + TCS
Sbjct: 480 PG----WSPLKTLA----GHEGKVMGLDISSDGQLIATCS 511
Score = 70.1 bits (170), Expect = 4e-12
Identities = 47/169 (27%), Positives = 79/169 (45%), Gaps = 24/169 (14%)
Query: 60 CKAVLDETHTRTVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSV 119
C + D+ R + C +SP+ K+LATA + +W D + TL GH V ++
Sbjct: 225 CSQIGDD---RPISYCHFSPNSKMLATACWSGLCKLWS--VPDCNLLHTLRGHNTNVGAI 279
Query: 120 SWNASGTL--------LATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTED 171
++ T+ LA+C+ D SV +W + + E V+ ++GHT V V WHP+
Sbjct: 280 VFHPKSTVSLDPKDVNLASCAADGSVKLWSL---DSDEPVADIEGHTVRVARVMWHPSGR 336
Query: 172 ILISCSYDNSIKVWADEGDSDDWQCVQTLGQPNNGHTSTVWALSFNASG 220
L + YD S ++W E + GH+ V+ ++F+ G
Sbjct: 337 FLGTTCYDRSWRLWDLEAQEEILH--------QEGHSMGVYDIAFHQDG 377
Score = 62.4 bits (150), Expect = 9e-10
Identities = 38/130 (29%), Positives = 63/130 (48%), Gaps = 14/130 (10%)
Query: 12 LEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDETHTRT 71
LEGH ++ ++++P H T SGD T ++W+ ++ A H
Sbjct: 403 LEGHLKEIYGINFSPNGYHIATG------SGDNTCKVWDLRQRRCVYTIPA-----HQNL 451
Query: 72 VRSCAWSP-SGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTLLAT 130
V + P G L T ++D T IW + G + + TL GHE +V + ++ G L+AT
Sbjct: 452 VTGVKFEPIHGNFLLTGAYDNTAKIWTHPG--WSPLKTLAGHEGKVMGLDISSDGQLIAT 509
Query: 131 CSRDKSVWIW 140
CS D++ +W
Sbjct: 510 CSYDRTFKLW 519
Score = 53.9 bits (128), Expect = 3e-07
Identities = 39/151 (25%), Positives = 70/151 (45%), Gaps = 13/151 (8%)
Query: 79 PSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTLLATCSRDKSVW 138
P LA+ + D + +W ++ D E VA +EGH V V W+ SG L T D+S
Sbjct: 291 PKDVNLASCAADGSVKLW-SLDSD-EPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWR 348
Query: 139 IWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVWADEGDSDDWQCVQ 198
+W+++ E + +GH+ V + +H + + D +VW D +C+
Sbjct: 349 LWDLEAQEE---ILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVW----DLRTGRCIM 401
Query: 199 TLGQPNNGHTSTVWALSFNASGDKMVTCSSN 229
L GH ++ ++F+ +G + T S +
Sbjct: 402 FL----EGHLKEIYGINFSPNGYHIATGSGD 428
>HUS7_MOUSE (Q8VEJ4) WD-repeat protein HUSSY-07
Length = 485
Score = 91.7 bits (226), Expect = 1e-18
Identities = 68/209 (32%), Positives = 98/209 (46%), Gaps = 27/209 (12%)
Query: 12 LEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDETHTRT 71
LEGH++ V S+ ++P T AS SGD TVR W+ + + CK H
Sbjct: 110 LEGHSEAVISVAFSP------TGKYLASGSGDTTVRFWDLSTETPHFTCKG-----HRHW 158
Query: 72 VRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSW-----NASGT 126
V S +WSP GK LA+ + +W+ G + TL GH + +SW N
Sbjct: 159 VLSISWSPDGKKLASGCKNGQILLWDPSTG-LQVGRTLTGHSKWITGLSWEPLHMNPECR 217
Query: 127 LLATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVWA 186
+A+ S+D SV +W+ C +L GHTQ V ++W + +L S S D +IKVW
Sbjct: 218 YVASSSKDGSVRVWD---TTAGRCERILTGHTQSVTCLRW-GGDGLLYSASQDRTIKVWR 273
Query: 187 DEGDSDDWQCVQTLGQPNNGHTSTVWALS 215
+ D +TL +GH ALS
Sbjct: 274 ----AHDGVLCRTL--QGHGHWVNTMALS 296
Score = 69.3 bits (168), Expect = 7e-12
Identities = 48/162 (29%), Positives = 76/162 (46%), Gaps = 21/162 (12%)
Query: 66 ETHTRTVRSCAWSPSGKLLATASFDATTAIWE--NVGGDFECVATLEGHENEVKSVSWNA 123
E H+ V S A+SP+GK LA+ S D T W+ F C +GH + V S+SW+
Sbjct: 111 EGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTC----KGHRHWVLSISWSP 166
Query: 124 SGTLLATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTE-----DILISCSY 178
G LA+ ++ + +W+ P + L GH++ + + W P + S S
Sbjct: 167 DGKKLASGCKNGQILLWD--PSTGLQVGRTLTGHSKWITGLSWEPLHMNPECRYVASSSK 224
Query: 179 DNSIKVWADEGDSDDWQCVQTLGQPNNGHTSTVWALSFNASG 220
D S++VW D+ +C + L GHT +V L + G
Sbjct: 225 DGSVRVW----DTTAGRCERIL----TGHTQSVTCLRWGGDG 258
Score = 66.6 bits (161), Expect = 5e-11
Identities = 33/118 (27%), Positives = 60/118 (49%), Gaps = 5/118 (4%)
Query: 68 HTRTVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTL 127
H + +SP +++A+ASFD + +W+ G + +A+L GH V ++W+A L
Sbjct: 371 HQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKY--LASLRGHVAAVYQIAWSADSRL 428
Query: 128 LATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVW 185
L + S D ++ +W+ V + + L GH +V V W P + S D +++W
Sbjct: 429 LVSGSSDSTLKVWD---VKAQKLATDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 59.7 bits (143), Expect = 6e-09
Identities = 64/265 (24%), Positives = 111/265 (41%), Gaps = 61/265 (23%)
Query: 12 LEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDETHTRT 71
L GH+ + L W P + V AS S D +VR+W D ++G C+ +L HT++
Sbjct: 195 LTGHSKWITGLSWEPLHMNPECRYV-ASSSKDGSVRVW--DTTAG--RCERILTG-HTQS 248
Query: 72 VRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTL---- 127
V W G LL +AS D T +W D TL+GH + V +++ + L
Sbjct: 249 VTCLRWGGDG-LLYSASQDRTIKVWR--AHDGVLCRTLQGHGHWVNTMALSTDYALRTGA 305
Query: 128 --------------------------------------LATCSRDKSVWIWEMQPVNEFE 149
L + S D ++++W P + +
Sbjct: 306 FEPAEATVNAQDLQGSLKELKERASSRYNLVRGQGPERLVSGSDDFTLFLWS--PAEDKK 363
Query: 150 CVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVWADEGDSDDWQCVQTLGQPNNGHTS 209
++ + GH + V + P I+ S S+D SIK+W D + + +L GH +
Sbjct: 364 PLARMTGHQALINQVLFSPDSRIVASASFDKSIKLW----DGRTGKYLASL----RGHVA 415
Query: 210 TVWALSFNASGDKMVTCSSNLLMAV 234
V+ ++++A +V+ SS+ + V
Sbjct: 416 AVYQIAWSADSRLLVSGSSDSTLKV 440
Score = 45.8 bits (107), Expect = 9e-05
Identities = 32/113 (28%), Positives = 51/113 (44%), Gaps = 12/113 (10%)
Query: 105 CVATLEGHENEVKSVSWNASGTLLATCSRDKSVWIWEMQ-PVNEFECVSVLQGHTQDVKM 163
C ++LEGH V SV+++ +G LA+ S D +V W++ F C +GH V
Sbjct: 106 CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTC----KGHRHWVLS 161
Query: 164 VKWHPTEDILISCSYDNSIKVWADEGDSDDWQCVQTLGQPNNGHTSTVWALSF 216
+ W P L S + I +W D +G+ GH+ + LS+
Sbjct: 162 ISWSPDGKKLASGCKNGQILLW-------DPSTGLQVGRTLTGHSKWITGLSW 207
Score = 30.0 bits (66), Expect = 4.9
Identities = 15/40 (37%), Positives = 21/40 (52%), Gaps = 6/40 (15%)
Query: 12 LEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQ 51
L GH D V+++DW+P AS DK +RIW +
Sbjct: 452 LPGHADEVYAVDWSPDGQRV------ASGGKDKCLRIWRR 485
>HUS7_HUMAN (Q9NVX2) WD-repeat protein HUSSY-07
Length = 485
Score = 91.7 bits (226), Expect = 1e-18
Identities = 69/209 (33%), Positives = 98/209 (46%), Gaps = 27/209 (12%)
Query: 12 LEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDETHTRT 71
LEGH++ V S+ ++P T AS SGD TVR W+ + + CK H
Sbjct: 110 LEGHSEAVISVAFSP------TGKYLASGSGDTTVRFWDLSTETPHFTCKG-----HRHW 158
Query: 72 VRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSW-----NASGT 126
V S +WSP GK LA+ + +W+ G + TL GH + +SW N
Sbjct: 159 VLSISWSPDGKKLASGCKNGQILLWDPSTGK-QVGRTLAGHSKWITGLSWEPLHANPECR 217
Query: 127 LLATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVWA 186
+A+ S+D SV IW+ C +L GHTQ V ++W + +L S S D +IKVW
Sbjct: 218 YVASSSKDGSVRIWD---TTAGRCERILTGHTQSVTCLRW-GGDGLLYSASQDRTIKVWR 273
Query: 187 DEGDSDDWQCVQTLGQPNNGHTSTVWALS 215
+ D +TL +GH ALS
Sbjct: 274 ----AHDGVLCRTL--QGHGHWVNTMALS 296
Score = 67.8 bits (164), Expect = 2e-11
Identities = 47/162 (29%), Positives = 76/162 (46%), Gaps = 21/162 (12%)
Query: 66 ETHTRTVRSCAWSPSGKLLATASFDATTAIWE--NVGGDFECVATLEGHENEVKSVSWNA 123
E H+ V S A+SP+GK LA+ S D T W+ F C +GH + V S+SW+
Sbjct: 111 EGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTC----KGHRHWVLSISWSP 166
Query: 124 SGTLLATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTE-----DILISCSY 178
G LA+ ++ + +W+ P + L GH++ + + W P + S S
Sbjct: 167 DGKKLASGCKNGQILLWD--PSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSK 224
Query: 179 DNSIKVWADEGDSDDWQCVQTLGQPNNGHTSTVWALSFNASG 220
D S+++W D+ +C + L GHT +V L + G
Sbjct: 225 DGSVRIW----DTTAGRCERIL----TGHTQSVTCLRWGGDG 258
Score = 65.9 bits (159), Expect = 8e-11
Identities = 33/118 (27%), Positives = 59/118 (49%), Gaps = 5/118 (4%)
Query: 68 HTRTVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTL 127
H + +SP +++A+ASFD + +W+ G + +A+L GH V ++W+A L
Sbjct: 371 HQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKY--LASLRGHVAAVYQIAWSADSRL 428
Query: 128 LATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVW 185
L + S D ++ +W+ V + L GH +V V W P + S D +++W
Sbjct: 429 LVSGSSDSTLKVWD---VKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 62.0 bits (149), Expect = 1e-09
Identities = 68/271 (25%), Positives = 115/271 (42%), Gaps = 62/271 (22%)
Query: 7 KEVQR-LEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLD 65
K+V R L GH+ + L W P + V AS S D +VRIW D ++G C+ +L
Sbjct: 189 KQVGRTLAGHSKWITGLSWEPLHANPECRYV-ASSSKDGSVRIW--DTTAG--RCERILT 243
Query: 66 ETHTRTVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASG 125
HT++V W G LL +AS D T +W D TL+GH + V +++ +
Sbjct: 244 G-HTQSVTCLRWGGDG-LLYSASQDRTIKVWR--AHDGVLCRTLQGHGHWVNTMALSTDY 299
Query: 126 TL------------------------------------------LATCSRDKSVWIWEMQ 143
L L + S D ++++W
Sbjct: 300 ALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWS-- 357
Query: 144 PVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVWADEGDSDDWQCVQTLGQP 203
P + + ++ + GH + V + P I+ S S+D SIK+W D + + +L
Sbjct: 358 PAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLW----DGRTGKYLASL--- 410
Query: 204 NNGHTSTVWALSFNASGDKMVTCSSNLLMAV 234
GH + V+ ++++A +V+ SS+ + V
Sbjct: 411 -RGHVAAVYQIAWSADSRLLVSGSSDSTLKV 440
Score = 46.2 bits (108), Expect = 7e-05
Identities = 32/113 (28%), Positives = 52/113 (45%), Gaps = 12/113 (10%)
Query: 105 CVATLEGHENEVKSVSWNASGTLLATCSRDKSVWIWEMQ-PVNEFECVSVLQGHTQDVKM 163
C ++LEGH V SV+++ +G LA+ S D +V W++ F C +GH V
Sbjct: 106 CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTC----KGHRHWVLS 161
Query: 164 VKWHPTEDILISCSYDNSIKVWADEGDSDDWQCVQTLGQPNNGHTSTVWALSF 216
+ W P L S + I +W D + +G+ GH+ + LS+
Sbjct: 162 ISWSPDGKKLASGCKNGQILLW-------DPSTGKQVGRTLAGHSKWITGLSW 207
Score = 30.0 bits (66), Expect = 4.9
Identities = 15/40 (37%), Positives = 21/40 (52%), Gaps = 6/40 (15%)
Query: 12 LEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQ 51
L GH D V+++DW+P AS DK +RIW +
Sbjct: 452 LPGHADEVYAVDWSPDGQRV------ASGGKDKCLRIWRR 485
>EBI_DROME (Q95RJ9) F-box-like/WD-repeat protein ebi
Length = 700
Score = 90.9 bits (224), Expect = 2e-18
Identities = 78/325 (24%), Positives = 122/325 (37%), Gaps = 116/325 (35%)
Query: 2 ERLELKEVQR--LEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWE--------- 50
E +E+ E + L GH V+ WNP+ + AS SGD T RIW+
Sbjct: 339 ENIEIPESKARVLRGHESEVFICAWNPSRD------LLASGSGDSTARIWDMSDANTNSN 392
Query: 51 ------------------QDLSSGLWACKAVLDET----------------------HTR 70
+D++S W C L T H
Sbjct: 393 QLVLRHCIQKGGAEVPSNKDVTSLDWNCDGSLLATGSYDGYARIWKTDGRLASTLGQHKG 452
Query: 71 TVRSCAWSPSGKLLATASFDATTAIWENVGGDF--------------------------- 103
+ + W+ G + +A D TT IW+ G
Sbjct: 453 PIFALKWNKCGNYILSAGVDKTTIIWDASTGQCTQQFAFHSAPALDVDWQTNQAFASCST 512
Query: 104 ------------ECVATLEGHENEVKSVSWNASGTLLATCSRDKSVWIWEMQPVNEFECV 151
E + T +GH NEV ++ W G LLA+CS D ++ IW M N C
Sbjct: 513 DQRIHVCRLGVNEPIKTFKGHTNEVNAIKWCPQGQLLASCSDDMTLKIWSM---NRDRCC 569
Query: 152 SVLQGHTQDVKMVKWHPTED---------ILISCSYDNSIKVWADEGDSDDWQCVQTLGQ 202
LQ H++++ +KW PT IL S S+D+++++W D + C+ TL +
Sbjct: 570 HDLQAHSKEIYTIKWSPTGPGTNNPNTNLILASASFDSTVRLW----DVERGSCIHTLTK 625
Query: 203 PNNGHTSTVWALSFNASGDKMVTCS 227
HT V++++F+ G + + S
Sbjct: 626 ----HTEPVYSVAFSPDGKHLASGS 646
Score = 79.3 bits (194), Expect = 7e-15
Identities = 52/188 (27%), Positives = 85/188 (44%), Gaps = 26/188 (13%)
Query: 10 QRLEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDETHT 69
Q+ H+ +DW T FASCS D+ + + ++ + K HT
Sbjct: 487 QQFAFHSAPALDVDWQ-------TNQAFASCSTDQRIHVCRLGVNEPIKTFKG-----HT 534
Query: 70 RTVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGT--- 126
V + W P G+LLA+ S D T IW ++ D C L+ H E+ ++ W+ +G
Sbjct: 535 NEVNAIKWCPQGQLLASCSDDMTLKIW-SMNRD-RCCHDLQAHSKEIYTIKWSPTGPGTN 592
Query: 127 ------LLATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDN 180
+LA+ S D +V +W+ V C+ L HT+ V V + P L S S+D
Sbjct: 593 NPNTNLILASASFDSTVRLWD---VERGSCIHTLTKHTEPVYSVAFSPDGKHLASGSFDK 649
Query: 181 SIKVWADE 188
+ +W+ +
Sbjct: 650 CVHIWSTQ 657
Score = 73.2 bits (178), Expect = 5e-13
Identities = 45/135 (33%), Positives = 72/135 (53%), Gaps = 11/135 (8%)
Query: 12 LEGHNDRVWSLDWNPA---TGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDETH 68
L+ H+ ++++ W+P T + T L+ AS S D TVR+W+ + S C L + H
Sbjct: 572 LQAHSKEIYTIKWSPTGPGTNNPNTNLILASASFDSTVRLWDVERGS----CIHTLTK-H 626
Query: 69 TRTVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTLL 128
T V S A+SP GK LA+ SFD IW G + V + +G + V WN+ GT +
Sbjct: 627 TEPVYSVAFSPDGKHLASGSFDKCVHIWSTQTG--QLVHSYKG-TGGIFEVCWNSKGTKV 683
Query: 129 ATCSRDKSVWIWEMQ 143
+ D SV++ +++
Sbjct: 684 GASASDGSVFVLDLR 698
Score = 61.2 bits (147), Expect = 2e-09
Identities = 57/216 (26%), Positives = 92/216 (42%), Gaps = 38/216 (17%)
Query: 27 ATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDETHTRTVRSCAWSPSGKLLAT 86
A+G A T + SG T+R+ Q + + + + + +PSG + ++
Sbjct: 274 ASGGASTATGSKAPSGAVTIRVGAQG------------NNVQSGSSNAQSSAPSGTISSS 321
Query: 87 ASFDATTA-------IWENVGGDFECVATLEGHENEVKSVSWNASGTLLATCSRDKSVWI 139
S A T I EN+ L GHE+EV +WN S LLA+ S D + I
Sbjct: 322 TSGGAGTPAALVPMDIDENIEIPESKARVLRGHESEVFICAWNPSRDLLASGSGDSTARI 381
Query: 140 WEMQPVNEFECVSVLQGHTQ----------DVKMVKWHPTEDILISCSYDNSIKVWADEG 189
W+M N VL+ Q DV + W+ +L + SYD ++W +G
Sbjct: 382 WDMSDANTNSNQLVLRHCIQKGGAEVPSNKDVTSLDWNCDGSLLATGSYDGYARIWKTDG 441
Query: 190 DSDDWQCVQTLGQPNNGHTSTVWALSFNASGDKMVT 225
+ TLGQ H ++AL +N G+ +++
Sbjct: 442 -----RLASTLGQ----HKGPIFALKWNKCGNYILS 468
>PKWA_THECU (P49695) Probable serine/threonine-protein kinase pkwA
(EC 2.7.1.37)
Length = 742
Score = 88.2 bits (217), Expect = 2e-17
Identities = 58/174 (33%), Positives = 98/174 (55%), Gaps = 17/174 (9%)
Query: 12 LEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDETHTRT 71
L+GH D V+++ ++P + AS S D T+R+W D+++G + VL +
Sbjct: 581 LKGHTDYVYAVAFSPDGS------MVASGSRDGTIRLW--DVATGKE--RDVL-QAPAEN 629
Query: 72 VRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTLLATC 131
V S A+SP G +L S D+T +W+ G E + T EGH + V++V+++ G LLA+
Sbjct: 630 VVSLAFSPDGSMLVHGS-DSTVHLWDVASG--EALHTFEGHTDWVRAVAFSPDGALLASG 686
Query: 132 SRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVW 185
S D+++ +W++ E + L+GHT+ V V +HP L S S D +I++W
Sbjct: 687 SDDRTIRLWDVAAQEEH---TTLEGHTEPVHSVAFHPEGTTLASASEDGTIRIW 737
Score = 83.2 bits (204), Expect = 5e-16
Identities = 62/222 (27%), Positives = 109/222 (48%), Gaps = 25/222 (11%)
Query: 8 EVQRLEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDET 67
E+ LEGH D W A + + AS S D TVR+W+ + + + E
Sbjct: 493 ELHTLEGHTD------WVRAVAFSPDGALLASGSDDATVRLWDVAAAE-----ERAVFEG 541
Query: 68 HTRTVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTL 127
HT V A+SP G ++A+ S D T +W G V L+GH + V +V+++ G++
Sbjct: 542 HTHYVLDIAFSPDGSMVASGSRDGTARLWNVATGTEHAV--LKGHTDYVYAVAFSPDGSM 599
Query: 128 LATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVWAD 187
+A+ SRD ++ +W++ E + VLQ ++V + + P +L+ S D+++ +W
Sbjct: 600 VASGSRDGTIRLWDVATGKERD---VLQAPAENVVSLAFSPDGSMLVHGS-DSTVHLW-- 653
Query: 188 EGDSDDWQCVQTLGQPNNGHTSTVWALSFNASGDKMVTCSSN 229
D + + T GHT V A++F+ G + + S +
Sbjct: 654 --DVASGEALHTF----EGHTDWVRAVAFSPDGALLASGSDD 689
Score = 81.6 bits (200), Expect = 1e-15
Identities = 51/150 (34%), Positives = 83/150 (55%), Gaps = 10/150 (6%)
Query: 36 VFASCSGDKTVRIWEQDLSSGLWACKAVLDETHTRTVRSCAWSPSGKLLATASFDATTAI 95
+ A SGDK + +W D++SG + E HT VR+ A+SP G LLA+ S DAT +
Sbjct: 473 LLAGGSGDKLIHVW--DVASG---DELHTLEGHTDWVRAVAFSPDGALLASGSDDATVRL 527
Query: 96 WENVGGDFECVATLEGHENEVKSVSWNASGTLLATCSRDKSVWIWEMQPVNEFECVSVLQ 155
W+ + A EGH + V ++++ G+++A+ SRD + +W + E +VL+
Sbjct: 528 WDVAAAEER--AVFEGHTHYVLDIAFSPDGSMVASGSRDGTARLWNVATGTEH---AVLK 582
Query: 156 GHTQDVKMVKWHPTEDILISCSYDNSIKVW 185
GHT V V + P ++ S S D +I++W
Sbjct: 583 GHTDYVYAVAFSPDGSMVASGSRDGTIRLW 612
Score = 71.6 bits (174), Expect = 1e-12
Identities = 49/161 (30%), Positives = 80/161 (49%), Gaps = 13/161 (8%)
Query: 67 THTRTVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGT 126
T R + A+SP G LLA S D +W+ GD + TLEGH + V++V+++ G
Sbjct: 457 TTDREAVAVAFSPGGSLLAGGSGDKLIHVWDVASGDE--LHTLEGHTDWVRAVAFSPDGA 514
Query: 127 LLATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVWA 186
LLA+ S D +V +W++ E +V +GHT V + + P ++ S S D + ++W
Sbjct: 515 LLASGSDDATVRLWDVAAAEE---RAVFEGHTHYVLDIAFSPDGSMVASGSRDGTARLWN 571
Query: 187 DEGDSDDWQCVQTLGQPNNGHTSTVWALSFNASGDKMVTCS 227
T GHT V+A++F+ G + + S
Sbjct: 572 --------VATGTEHAVLKGHTDYVYAVAFSPDGSMVASGS 604
Score = 65.9 bits (159), Expect = 8e-11
Identities = 48/134 (35%), Positives = 67/134 (49%), Gaps = 14/134 (10%)
Query: 7 KEVQRLEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDE 66
KE L+ + V SL ++P G+ LV S D TV +W+ L E
Sbjct: 618 KERDVLQAPAENVVSLAFSPD----GSMLVHGS---DSTVHLWDVASGEALHTF-----E 665
Query: 67 THTRTVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGT 126
HT VR+ A+SP G LLA+ S D T +W+ + TLEGH V SV+++ GT
Sbjct: 666 GHTDWVRAVAFSPDGALLASGSDDRTIRLWDVAAQEEH--TTLEGHTEPVHSVAFHPEGT 723
Query: 127 LLATCSRDKSVWIW 140
LA+ S D ++ IW
Sbjct: 724 TLASASEDGTIRIW 737
>YKY4_CAEEL (Q17963) Hypothetical WD-repeat protein C14B1.4 in
chromosome III
Length = 376
Score = 87.8 bits (216), Expect = 2e-17
Identities = 61/194 (31%), Positives = 92/194 (46%), Gaps = 20/194 (10%)
Query: 12 LEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDETHTRT 71
LEGH + S ++P + GT S DKTV+IW D C+ L H
Sbjct: 83 LEGHTKSISSAKFSPCGKYLGTS------SADKTVKIWNMD----HMICERTL-TGHKLG 131
Query: 72 VRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTLLATC 131
V AWS + + +AS D T I+E V TL+GH N V ++N +L+ +
Sbjct: 132 VNDIAWSSDSRCVVSASDDKTLKIFEIVTS--RMTKTLKGHNNYVFCCNFNPQSSLVVSG 189
Query: 132 SRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVWADEGDS 191
S D+SV IW+ V C+ L H+ V V ++ ++ S SYD +++W D+
Sbjct: 190 SFDESVRIWD---VKTGMCIKTLPAHSDPVSAVSFNRDGSLIASGSYDGLVRIW----DT 242
Query: 192 DDWQCVQTLGQPNN 205
+ QC++TL N
Sbjct: 243 ANGQCIKTLVDDEN 256
Score = 83.2 bits (204), Expect = 5e-16
Identities = 50/169 (29%), Positives = 85/169 (49%), Gaps = 13/169 (7%)
Query: 66 ETHTRTVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASG 125
E HT+++ S +SP GK L T+S D T IW C TL GH+ V ++W++
Sbjct: 84 EGHTKSISSAKFSPCGKYLGTSSADKTVKIWNM--DHMICERTLTGHKLGVNDIAWSSDS 141
Query: 126 TLLATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVW 185
+ + S DK++ I+E + L+GH V ++P +++S S+D S+++W
Sbjct: 142 RCVVSASDDKTLKIFE---IVTSRMTKTLKGHNNYVFCCNFNPQSSLVVSGSFDESVRIW 198
Query: 186 ADEGDSDDWQCVQTLGQPNNGHTSTVWALSFNASGDKMVTCSSNLLMAV 234
D C++TL H+ V A+SFN G + + S + L+ +
Sbjct: 199 ----DVKTGMCIKTL----PAHSDPVSAVSFNRDGSLIASGSYDGLVRI 239
Score = 75.5 bits (184), Expect = 1e-13
Identities = 61/218 (27%), Positives = 99/218 (44%), Gaps = 31/218 (14%)
Query: 14 GHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDETHTRTVR 73
G ND WS D S S DKT++I+E S K H V
Sbjct: 131 GVNDIAWSSDSR----------CVVSASDDKTLKIFEIVTSRMTKTLKG-----HNNYVF 175
Query: 74 SCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTLLATCSR 133
C ++P L+ + SFD + IW+ G C+ TL H + V +VS+N G+L+A+ S
Sbjct: 176 CCNFNPQSSLVVSGSFDESVRIWDVKTG--MCIKTLPAHSDPVSAVSFNRDGSLIASGSY 233
Query: 134 DKSVWIWEMQPVNEFECVSVL-QGHTQDVKMVKWHPTEDILISCSYDNSIKVWADEGDSD 192
D V IW+ +C+ L V VK+ P +++ + D+++K+W
Sbjct: 234 DGLVRIWD---TANGQCIKTLVDDENPPVAFVKFSPNGKYILASNLDSTLKLW------- 283
Query: 193 DWQCVQTLGQPNNGHTSTVWAL--SFNASGDKMVTCSS 228
D+ +TL Q GH ++ + + +F+ +G K + S
Sbjct: 284 DFSKGKTLKQ-YTGHENSKYCIFANFSVTGGKWIISGS 320
Score = 68.6 bits (166), Expect = 1e-11
Identities = 53/185 (28%), Positives = 87/185 (46%), Gaps = 20/185 (10%)
Query: 9 VQRLEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDETH 68
++ L H+D V ++ +N + AS S D VRIW D ++G C L +
Sbjct: 206 IKTLPAHSDPVSAVSFNRDGS------LIASGSYDGLVRIW--DTANG--QCIKTLVDDE 255
Query: 69 TRTVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNAS---G 125
V +SP+GK + ++ D+T +W+ G + + GHEN + N S G
Sbjct: 256 NPPVAFVKFSPNGKYILASNLDSTLKLWDFSKG--KTLKQYTGHENSKYCIFANFSVTGG 313
Query: 126 TLLATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSY--DNSIK 183
+ + S D ++IW +Q +C L+GHTQ V HP ++I+ S + DN I
Sbjct: 314 KWIISGSEDCKIYIWNLQTREIVQC---LEGHTQPVLASDCHPVQNIIASGALEPDNKIH 370
Query: 184 VWADE 188
+W +
Sbjct: 371 IWRSD 375
>WDS_DROME (Q9V3J8) Will die slowly protein
Length = 361
Score = 87.0 bits (214), Expect = 3e-17
Identities = 49/160 (30%), Positives = 89/160 (55%), Gaps = 13/160 (8%)
Query: 68 HTRTVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTL 127
HT+ V + +SP+G+ LA++S D IW G FE T+ GH+ + V+W++ L
Sbjct: 71 HTKAVSAVKFSPNGEWLASSSADKLIKIWGAYDGKFE--KTISGHKLGISDVAWSSDSRL 128
Query: 128 LATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVWAD 187
L + S DK++ +WE+ + + + L+GH+ V ++P ++++S S+D S+++W
Sbjct: 129 LVSGSDDKTLKVWEL---STGKSLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW-- 183
Query: 188 EGDSDDWQCVQTLGQPNNGHTSTVWALSFNASGDKMVTCS 227
D +C++TL H+ V A+ FN G +V+ S
Sbjct: 184 --DVRTGKCLKTL----PAHSDPVSAVHFNRDGSLIVSSS 217
Score = 80.5 bits (197), Expect = 3e-15
Identities = 59/203 (29%), Positives = 94/203 (46%), Gaps = 26/203 (12%)
Query: 12 LEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDET---H 68
L GH V ++ ++P AS S DK ++IW A ++T H
Sbjct: 68 LAGHTKAVSAVKFSPNGEW------LASSSADKLIKIW--------GAYDGKFEKTISGH 113
Query: 69 TRTVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTLL 128
+ AWS +LL + S D T +WE G + + TL+GH N V ++N L+
Sbjct: 114 KLGISDVAWSSDSRLLVSGSDDKTLKVWELSTG--KSLKTLKGHSNYVFCCNFNPQSNLI 171
Query: 129 ATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVWADE 188
+ S D+SV IW+ V +C+ L H+ V V ++ +++S SYD ++W
Sbjct: 172 VSGSFDESVRIWD---VRTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW--- 225
Query: 189 GDSDDWQCVQTLGQPNNGHTSTV 211
D+ QC++TL +N S V
Sbjct: 226 -DTASGQCLKTLIDDDNPPVSFV 247
Score = 80.1 bits (196), Expect = 4e-15
Identities = 62/187 (33%), Positives = 93/187 (49%), Gaps = 20/187 (10%)
Query: 7 KEVQRLEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDE 66
K ++ L H+D V ++ +N G+ +V S S D RIW D +SG C L +
Sbjct: 189 KCLKTLPAHSDPVSAVHFN----RDGSLIV--SSSYDGLCRIW--DTASG--QCLKTLID 238
Query: 67 THTRTVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNAS-- 124
V +SP+GK + A+ D T +W+ G +C+ T GH+NE + N S
Sbjct: 239 DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKG--KCLKTYTGHKNEKYCIFANFSVT 296
Query: 125 -GTLLATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDN--S 181
G + + S D V+IW +Q E V LQGHT V HPTE+I+ S + +N +
Sbjct: 297 GGKWIVSGSEDNMVYIWNLQSK---EVVQKLQGHTDTVLCTACHPTENIIASAALENDKT 353
Query: 182 IKVWADE 188
IK+W +
Sbjct: 354 IKLWKSD 360
Score = 79.7 bits (195), Expect = 5e-15
Identities = 56/218 (25%), Positives = 100/218 (45%), Gaps = 31/218 (14%)
Query: 14 GHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDETHTRTVR 73
G +D WS D + S S DKT+++WE L K H+ V
Sbjct: 116 GISDVAWSSDSR----------LLVSGSDDKTLKVWELSTGKSLKTLKG-----HSNYVF 160
Query: 74 SCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTLLATCSR 133
C ++P L+ + SFD + IW+ G +C+ TL H + V +V +N G+L+ + S
Sbjct: 161 CCNFNPQSNLIVSGSFDESVRIWDVRTG--KCLKTLPAHSDPVSAVHFNRDGSLIVSSSY 218
Query: 134 DKSVWIWEMQPVNEFECV-SVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVWADEGDSD 192
D IW+ +C+ +++ V VK+ P +++ + DN++K+W D
Sbjct: 219 DGLCRIWD---TASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW----DYS 271
Query: 193 DWQCVQTLGQPNNGHTSTVWAL--SFNASGDKMVTCSS 228
+C++T GH + + + +F+ +G K + S
Sbjct: 272 KGKCLKTY----TGHKNEKYCIFANFSVTGGKWIVSGS 305
Score = 53.1 bits (126), Expect = 5e-07
Identities = 36/120 (30%), Positives = 60/120 (50%), Gaps = 11/120 (9%)
Query: 108 TLEGHENEVKSVSWNASGTLLATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWH 167
TL GH V +V ++ +G LA+ S DK + IW +FE + GH + V W
Sbjct: 67 TLAGHTKAVSAVKFSPNGEWLASSSADKLIKIWGAYD-GKFE--KTISGHKLGISDVAWS 123
Query: 168 PTEDILISCSYDNSIKVWADEGDSDDWQCVQTLGQPNNGHTSTVWALSFNASGDKMVTCS 227
+L+S S D ++KVW + + ++TL GH++ V+ +FN + +V+ S
Sbjct: 124 SDSRLLVSGSDDKTLKVW----ELSTGKSLKTL----KGHSNYVFCCNFNPQSNLIVSGS 175
>Y163_SYNY3 (Q55563) Hypothetical WD-repeat protein sll0163
Length = 1693
Score = 86.3 bits (212), Expect = 6e-17
Identities = 61/218 (27%), Positives = 102/218 (45%), Gaps = 28/218 (12%)
Query: 12 LEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDETHTRT 71
L GH + + +LDW+ A G FA+ S D TV++W++ + H
Sbjct: 1051 LRGHQEAITALDWS-ADGQ-----YFATASADHTVKLWQRHGE------EVATLRGHEDW 1098
Query: 72 VRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTLLATC 131
VRS +SP + L T+ D T IW G E + +GH + V++ +N G +L T
Sbjct: 1099 VRSVHFSPHHQFLVTSGQDNTARIWNFAG---EQLTLCQGHADWVRNAEFNCHGQILLTA 1155
Query: 132 SRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVWADEGDS 191
SRD + +W++ E + + QGHT V+ ++ P +++CS D + ++W
Sbjct: 1156 SRDGTARLWDL----EGREIGLCQGHTSWVRNAQFSPDGQWIVTCSADGTARLWDLSS-- 1209
Query: 192 DDWQCVQTLGQPNNGHTSTVWALSFNASGDKMVTCSSN 229
QC L GH + V ++ G ++T SS+
Sbjct: 1210 ---QCFAVL----KGHQNWVNNALWSPDGQHIITSSSD 1240
Score = 84.0 bits (206), Expect = 3e-16
Identities = 58/217 (26%), Positives = 100/217 (45%), Gaps = 28/217 (12%)
Query: 13 EGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDETHTRTV 72
+GH D V + ++N G + + S D T R+W+ L + L + HT V
Sbjct: 1134 QGHADWVRNAEFN-CHGQ-----ILLTASRDGTARLWD------LEGREIGLCQGHTSWV 1181
Query: 73 RSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTLLATCS 132
R+ +SP G+ + T S D T +W+ +C A L+GH+N V + W+ G + T S
Sbjct: 1182 RNAQFSPDGQWIVTCSADGTARLWDLSS---QCFAVLKGHQNWVNNALWSPDGQHIITSS 1238
Query: 133 RDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVWADEGDSD 192
D + +W +C+ L+GH ++ ++ +++ S DN+ ++W EG
Sbjct: 1239 SDGTARVWS----RHGKCLGTLRGHDHNIHGARFSLDGQKIVTYSTDNTARLWTKEG--- 1291
Query: 193 DWQCVQTLGQPNNGHTSTVWALSFNASGDKMVTCSSN 229
TL GH V+ F+A G + T S++
Sbjct: 1292 ------TLLTILRGHQKEVYDADFSADGRFVFTVSAD 1322
Score = 76.3 bits (186), Expect = 6e-14
Identities = 62/219 (28%), Positives = 100/219 (45%), Gaps = 30/219 (13%)
Query: 12 LEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDET-HTR 70
L GH V+ D++ A VF + S D+T R W D+S K + T H+
Sbjct: 1297 LRGHQKEVYDADFS-----ADGRFVF-TVSADQTARQW--DISQ-----KDTITLTGHSH 1343
Query: 71 TVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTLLAT 130
VR+ ++P G L T S D T +W G ECVA L H+ V+ ++ G + T
Sbjct: 1344 WVRNAHFNPKGDRLLTVSRDKTARLWTTEG---ECVAVLADHQGWVREGQFSPDGQWIVT 1400
Query: 131 CSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVWADEGD 190
S DK+ +W + ++VL+GH V V++ P +++ S D + +VW + G
Sbjct: 1401 GSADKTAQLWNVLGKK----LTVLRGHQDAVLNVRFSPDSQYIVTASKDGTARVWNNTGR 1456
Query: 191 SDDWQCVQTLGQPNNGHTSTVWALSFNASGDKMVTCSSN 229
+ L + ++A F+A G +VT S +
Sbjct: 1457 E-----LAVL----RHYEKNIFAAEFSADGQFIVTASDD 1486
Score = 69.3 bits (168), Expect = 7e-12
Identities = 50/167 (29%), Positives = 75/167 (43%), Gaps = 24/167 (14%)
Query: 29 GHAGTPLVFASCSGDK----------TVRIWEQDLSSGLWACKAVLDETHTRTVRSCAWS 78
GH G P+ FA S D T RIW+ L L H V +S
Sbjct: 1504 GHEG-PVYFAQFSADSRYILTASVDNTARIWDF-LGRPLLTLAG-----HQSIVYQARFS 1556
Query: 79 PSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTLLATCSRDKSVW 138
P G L+AT S D T +W+ G + VA L GH+ V +V W+ G +L T S D +
Sbjct: 1557 PEGNLIATVSADHTARLWDRSG---KTVAVLYGHQGLVGTVDWSPDGQMLVTASNDGTAR 1613
Query: 139 IWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVW 185
+W++ + L+GH V+ ++ P +++ S D + K+W
Sbjct: 1614 LWDLSGRE----LLTLEGHGNWVRSAEFSPDGRWVLTSSADGTAKLW 1656
Score = 67.4 bits (163), Expect = 3e-11
Identities = 57/223 (25%), Positives = 97/223 (42%), Gaps = 28/223 (12%)
Query: 7 KEVQRLEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDE 66
K++ L GH D V ++ ++P + + T S D T R+W AVL
Sbjct: 1415 KKLTVLRGHQDAVLNVRFSPDSQYIVT------ASKDGTARVWNNTGRE-----LAVLRH 1463
Query: 67 THTRTVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGT 126
+ + + + +S G+ + TAS D T IWE VG + V GHE V ++A
Sbjct: 1464 -YEKNIFAAEFSADGQFIVTASDDNTAGIWEIVGRE---VGICRGHEGPVYFAQFSADSR 1519
Query: 127 LLATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVWA 186
+ T S D + IW+ + L GH V ++ P +++ + S D++ ++W
Sbjct: 1520 YILTASVDNTARIWDFLG----RPLLTLAGHQSIVYQARFSPEGNLIATVSADHTARLWD 1575
Query: 187 DEGDSDDWQCVQTLGQPNNGHTSTVWALSFNASGDKMVTCSSN 229
G + V L GH V + ++ G +VT S++
Sbjct: 1576 RSG-----KTVAVL----YGHQGLVGTVDWSPDGQMLVTASND 1609
Score = 64.7 bits (156), Expect = 2e-10
Identities = 42/145 (28%), Positives = 67/145 (45%), Gaps = 16/145 (11%)
Query: 83 LLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTLLATCSRDKSVWIWEM 142
L+ TA+ + +W G E + L GH+ + ++ W+A G AT S D +V +W+
Sbjct: 1028 LVLTATTNGIAYLWSFHG---ELINVLRGHQEAITALDWSADGQYFATASADHTVKLWQ- 1083
Query: 143 QPVNEFECVSVLQGHTQDVKMVKWHPTEDILISCSYDNSIKVWADEGDSDDWQCVQTLGQ 202
E V+ L+GH V+ V + P L++ DN+ ++W G+ TL Q
Sbjct: 1084 ---RHGEEVATLRGHEDWVRSVHFSPHHQFLVTSGQDNTARIWNFAGEQ------LTLCQ 1134
Query: 203 PNNGHTSTVWALSFNASGDKMVTCS 227
GH V FN G ++T S
Sbjct: 1135 ---GHADWVRNAEFNCHGQILLTAS 1156
Score = 62.4 bits (150), Expect = 9e-10
Identities = 50/192 (26%), Positives = 80/192 (41%), Gaps = 28/192 (14%)
Query: 41 SGDKTVRIWEQDLSSGLWACKAVLDETHTRTVRSCAWSPSGKLLATASFDATTAIWENVG 100
S D T R+W ++ + H + V +S G+ + T S D T W+
Sbjct: 1279 STDNTARLWTKE------GTLLTILRGHQKEVYDADFSADGRFVFTVSADQTARQWDISQ 1332
Query: 101 GDFECVATLEGHENEVKSVSWNASGTLLATCSRDKSVWIWEMQPVNEFECVSVLQGHTQD 160
D TL GH + V++ +N G L T SRDK+ +W E ECV+VL H
Sbjct: 1333 KD---TITLTGHSHWVRNAHFNPKGDRLLTVSRDKTARLW----TTEGECVAVLADHQGW 1385
Query: 161 VKMVKWHPTEDILISCSYDNSIKVWADEGDSDDWQCVQTLGQP---NNGHTSTVWALSFN 217
V+ ++ P +++ S D + ++W LG+ GH V + F+
Sbjct: 1386 VREGQFSPDGQWIVTGSADKTAQLW------------NVLGKKLTVLRGHQDAVLNVRFS 1433
Query: 218 ASGDKMVTCSSN 229
+VT S +
Sbjct: 1434 PDSQYIVTASKD 1445
Score = 61.6 bits (148), Expect = 2e-09
Identities = 41/132 (31%), Positives = 65/132 (49%), Gaps = 15/132 (11%)
Query: 12 LEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWEQDLSSGLWACKAVLDETHTRT 71
L GH V+ ++P + A+ S D T R+W++ + AVL H
Sbjct: 1543 LAGHQSIVYQARFSPEGN------LIATVSADHTARLWDRSGKT-----VAVL-YGHQGL 1590
Query: 72 VRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTLLATC 131
V + WSP G++L TAS D T +W+ G + + TLEGH N V+S ++ G + T
Sbjct: 1591 VGTVDWSPDGQMLVTASNDGTARLWDLSGRE---LLTLEGHGNWVRSAEFSPDGRWVLTS 1647
Query: 132 SRDKSVWIWEMQ 143
S D + +W ++
Sbjct: 1648 SADGTAKLWPVK 1659
>HIRA_DROME (O17468) HIRA protein homolog (dHIRA)
Length = 1047
Score = 86.3 bits (212), Expect = 6e-17
Identities = 55/177 (31%), Positives = 84/177 (47%), Gaps = 23/177 (12%)
Query: 66 ETHTRTVRSCAWSPSGKLLATASFDATTAIWENVGGD---------------FECVATLE 110
+ H V WS +G+ LA+ S D IW G ++C TL
Sbjct: 67 DQHLACVNCVRWSQNGQNLASGSDDKLIMIWRKSAGSSGVFGTGGMQKNHESWKCFYTLR 126
Query: 111 GHENEVKSVSWNASGTLLATCSRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWHPTE 170
GH+ +V ++W+ + LA+CS D +V IW+ Q V+ L+GHT VK V W P
Sbjct: 127 GHDGDVLDLAWSPNDVYLASCSIDNTVIIWDAQAFP--HSVATLKGHTGLVKGVSWDPLG 184
Query: 171 DILISCSYDNSIKVWADEGDSDDWQCVQTLGQP--NNGHTSTVWALSFNASGDKMVT 225
L S S D SIK+W ++ +W T+ +P G T+ + LS++ G +V+
Sbjct: 185 RFLASQSDDRSIKIW----NTMNWSLSHTITEPFEECGGTTHILRLSWSPDGQYLVS 237
Score = 71.6 bits (174), Expect = 1e-12
Identities = 60/198 (30%), Positives = 83/198 (41%), Gaps = 22/198 (11%)
Query: 38 ASCSGDKTVRIWEQDL-SSGL------------WACKAVLDETHTRTVRSCAWSPSGKLL 84
AS S DK + IW + SSG+ W C L H V AWSP+ L
Sbjct: 86 ASGSDDKLIMIWRKSAGSSGVFGTGGMQKNHESWKCFYTL-RGHDGDVLDLAWSPNDVYL 144
Query: 85 ATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTLLATCSRDKSVWIWEMQP 144
A+ S D T IW+ VATL+GH VK VSW+ G LA+ S D+S+ IW
Sbjct: 145 ASCSIDNTVIIWDAQAFPHS-VATLKGHTGLVKGVSWDPLGRFLASQSDDRSIKIWNTMN 203
Query: 145 VNEFECVSVLQ---GHTQDVKMVKWHPTEDILISCSYDNSIKVWADEGDSDDWQCVQTLG 201
+ ++ G T + + W P L+S N A + + W+C +
Sbjct: 204 WSLSHTITEPFEECGGTTHILRLSWSPDGQYLVSAHAMNGGGPTAQIIEREGWKCDKDF- 262
Query: 202 QPNNGHTSTVWALSFNAS 219
GH V + F+ S
Sbjct: 263 ---VGHRKAVTCVRFHNS 277
Score = 53.9 bits (128), Expect = 3e-07
Identities = 51/199 (25%), Positives = 77/199 (38%), Gaps = 39/199 (19%)
Query: 12 LEGHNDRVWSLDWNPATGHAGTPLVFASCSGDKTVRIWE-QDLSSGLWACKAVLDETHTR 70
L GH+ V L W+P + ASCS D TV IW+ Q + K HT
Sbjct: 125 LRGHDGDVLDLAWSP------NDVYLASCSIDNTVIIWDAQAFPHSVATLKG-----HTG 173
Query: 71 TVRSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLE----GHENEVKSVSWNASGT 126
V+ +W P G+ LA+ S D + IW + T G + +SW+ G
Sbjct: 174 LVKGVSWDPLGRFLASQSDDRSIKIWNTMNWSLSHTITEPFEECGGTTHILRLSWSPDGQ 233
Query: 127 LLATC----SRDKSVWIWEMQPVNEFECVSVLQGHTQDVKMVKWH------------PTE 170
L + + I E + ++C GH + V V++H P++
Sbjct: 234 YLVSAHAMNGGGPTAQIIERE---GWKCDKDFVGHRKAVTCVRFHNSILSRQENDGSPSK 290
Query: 171 DILISC----SYDNSIKVW 185
+ C S D S+ VW
Sbjct: 291 PLQYCCLAVGSRDRSLSVW 309
Score = 53.5 bits (127), Expect = 4e-07
Identities = 45/162 (27%), Positives = 66/162 (39%), Gaps = 30/162 (18%)
Query: 73 RSCAWSPSGKLLATASFDATTAIWENVGGDFECVATLEGHENEVKSVSWNASGTLLATCS 132
R W+ L A FDA + + ++ H V V W+ +G LA+ S
Sbjct: 39 RVVIWNLLPVLSDKAEFDADVP---------KMLCQMDQHLACVNCVRWSQNGQNLASGS 89
Query: 133 RDKSVWIWE-------------MQPVNE-FECVSVLQGHTQDVKMVKWHPTEDILISCSY 178
DK + IW MQ +E ++C L+GH DV + W P + L SCS
Sbjct: 90 DDKLIMIWRKSAGSSGVFGTGGMQKNHESWKCFYTLRGHDGDVLDLAWSPNDVYLASCSI 149
Query: 179 DNSIKVWADEGDSDDWQCVQTLGQPNNGHTSTVWALSFNASG 220
DN++ +W D Q GHT V +S++ G
Sbjct: 150 DNTVIIW-------DAQAFPHSVATLKGHTGLVKGVSWDPLG 184
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.316 0.129 0.421
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,474,189
Number of Sequences: 164201
Number of extensions: 1229385
Number of successful extensions: 6800
Number of sequences better than 10.0: 498
Number of HSP's better than 10.0 without gapping: 319
Number of HSP's successfully gapped in prelim test: 180
Number of HSP's that attempted gapping in prelim test: 2553
Number of HSP's gapped (non-prelim): 2022
length of query: 235
length of database: 59,974,054
effective HSP length: 107
effective length of query: 128
effective length of database: 42,404,547
effective search space: 5427782016
effective search space used: 5427782016
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Lotus: description of TM0010.22