BLASTP 2.2.2 [Dec-14-2001]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= TM0008.8
         (338 letters)

Database: sprot 
           164,201 sequences; 59,974,054 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

BIR_CHICK (Q90660) Inhibitor of apoptosis protein (IAP) (Inhibit...    56  1e-07
BIR3_HUMAN (Q13489) Baculoviral IAP repeat-containing protein 3 ...    54  4e-07
BIR2_HUMAN (Q13490) Baculoviral IAP repeat-containing protein 2 ...    54  6e-07
PIAP_PIG (O62640) Putative inhibitor of apoptosis                      54  7e-07
BIR2_MOUSE (Q62210) Baculoviral IAP repeat-containing protein 2 ...    54  7e-07
BIR3_MOUSE (O08863) Baculoviral IAP repeat-containing protein 3 ...    52  3e-06
RNGB_DICDI (Q7M3S9) Ring finger protein B (Protein rngB)               50  6e-06
BIR4_MOUSE (Q60989) Baculoviral IAP repeat-containing protein 4 ...    47  9e-05
BIR4_HUMAN (P98170) Baculoviral IAP repeat-containing protein 4 ...    47  9e-05
BIR4_RAT (Q9R0I6) Baculoviral IAP repeat-containing protein 4 (I...    46  2e-04
IAP_GVCP (P41436) Apoptosis inhibitor IAP                              44  6e-04
BIR8_GORGO (Q95M71) Baculoviral IAP repeat-containing protein 8 ...    44  6e-04
IAP1_NPVOP (O10296) Apoptosis inhibitor 1 (IAP-1)                      44  8e-04
BIR8_PANTR (Q95M72) Baculoviral IAP repeat-containing protein 8 ...    44  8e-04
BIR8_HUMAN (Q96P09) Baculoviral IAP repeat-containing protein 8 ...    43  0.001
BIR7_HUMAN (Q96CA5) Baculoviral IAP repeat-containing protein 7 ...    43  0.001
IAP2_DROME (Q24307) Apoptosis 2 inhibitor (Inhibitor of apoptosi...    41  0.004
M6_STRPY (P08089) M protein, serotype 6 precursor                      41  0.005
GEMI_HUMAN (O75496) Geminin                                            41  0.005
KTN1_HUMAN (Q86UP2) Kinectin (Kinesin receptor) (CG-1 antigen)         40  0.006

>BIR_CHICK (Q90660) Inhibitor of apoptosis protein (IAP) (Inhibitor
           of T cell apoptosis protein)
          Length = 611

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 28/88 (31%), Positives = 47/88 (52%), Gaps = 5/88 (5%)

Query: 251 FGDSEVDDAASYIDPNNFLSIPGAPMKSIHPRYQGMENLSCRACKAKDVSMLLIPCRHLS 310
           + D  V+ +  Y+   +   + G PM+    R Q  E  +C+ C  K+VS++ IPC HL 
Sbjct: 529 YKDLFVEKSMKYVPTED---VSGLPMEEQLRRLQ--EERTCKVCMDKEVSIVFIPCGHLV 583

Query: 311 LCKDCDGFINVCPVCQMIKTASVEVYLS 338
           +CK+C   +  CP+C+     +V  +LS
Sbjct: 584 VCKECAPSLRKCPICRGTIKGTVRTFLS 611


>BIR3_HUMAN (Q13489) Baculoviral IAP repeat-containing protein 3
           (Inhibitor of apoptosis protein 1) (HIAP1) (HIAP-1)
           (C-IAP2) (TNFR2-TRAF signaling complex protein 1) (IAP
           homolog C) (Apoptosis inhibitor 2) (API2)
          Length = 604

 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 21/52 (40%), Positives = 32/52 (61%)

Query: 287 ENLSCRACKAKDVSMLLIPCRHLSLCKDCDGFINVCPVCQMIKTASVEVYLS 338
           E  +C+ C  K+VS++ IPC HL +CKDC   +  CP+C+     +V  +LS
Sbjct: 553 EERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 604


>BIR2_HUMAN (Q13490) Baculoviral IAP repeat-containing protein 2
           (Inhibitor of apoptosis protein 2) (HIAP2) (HIAP-2)
           (C-IAP1) (TNFR2-TRAF signaling complex protein 2) (IAP
           homolog B)
          Length = 618

 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 50/218 (22%), Positives = 101/218 (45%), Gaps = 22/218 (10%)

Query: 129 SIILSLGDNIRTELDRQQEELDHYIKLQKEQLSRGVRDMKQKHMASLLTSIEKGIVKKLR 188
           S IL+ G+N +T  D     L+   + ++E+  +   +M    + SL+      + ++L 
Sbjct: 415 SKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDL-SLIRKNRMALFQQLT 473

Query: 189 EKEEEIENM------NRKNRELAERIKQVAVEAQNW--HYRAKYNESVVNALRNNLQQAI 240
                ++N+      N++  ++ ++  Q+ ++A+        K N +  N  +N L++  
Sbjct: 474 CVLPILDNLLKANVINKQEHDIIKQKTQIPLQARELIDTILVKGN-AAANIFKNCLKEID 532

Query: 241 SHGVEQGKEGFGDSEVDDAASYIDPNNFLSIPGAPMKSIHPRYQGMENLSCRACKAKDVS 300
           S         + +  VD    YI   +   + G  ++    R Q  E  +C+ C  K+VS
Sbjct: 533 S-------TLYKNLFVDKNMKYIPTED---VSGLSLEEQLRRLQ--EERTCKVCMDKEVS 580

Query: 301 MLLIPCRHLSLCKDCDGFINVCPVCQMIKTASVEVYLS 338
           ++ IPC HL +C++C   +  CP+C+ I   +V  +LS
Sbjct: 581 VVFIPCGHLVVCQECAPSLRKCPICRGIIKGTVRTFLS 618


>PIAP_PIG (O62640) Putative inhibitor of apoptosis
          Length = 358

 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 21/52 (40%), Positives = 32/52 (61%)

Query: 287 ENLSCRACKAKDVSMLLIPCRHLSLCKDCDGFINVCPVCQMIKTASVEVYLS 338
           E  +C+ C  K+VS++ IPC HL +CKDC   +  CP+C+     +V  +LS
Sbjct: 307 EERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRGTIKGTVRTFLS 358


>BIR2_MOUSE (Q62210) Baculoviral IAP repeat-containing protein 2
           (Inhibitor of apoptosis protein 2) (MIAP2) (MIAP-2)
          Length = 612

 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 46/216 (21%), Positives = 97/216 (44%), Gaps = 22/216 (10%)

Query: 131 ILSLGDNIRTE-------LDRQQEELDHYIKLQKEQLSRGVRDMKQKHMASLLTSIEKGI 183
           IL+ G+N RT        L+ + E  +   + Q E+++ G   + +K+  +L   +    
Sbjct: 411 ILATGENYRTVNDIVSVLLNAEDERREEEKERQTEEMASGDLSLIRKNRMALFQQLTH-- 468

Query: 184 VKKLREKEEEIENMNRKNRELAERIKQVAVEAQNWHYRAKYN-ESVVNALRNNLQQAISH 242
           V  + +   E   + ++  ++  +  Q+ ++A+           +  N  +N+L++  S 
Sbjct: 469 VLPILDNLLEASVITKQEHDIIRQKTQIPLQARELIDTVLVKGNAAANIFKNSLKEIDST 528

Query: 243 GVEQGKEGFGDSEVDDAASYIDPNNFLSIPGAPMKSIHPRYQGMENLSCRACKAKDVSML 302
             E       +  V+    YI   +   + G  ++    R Q  E  +C+ C  ++VS++
Sbjct: 529 LYE-------NLFVEKNMKYIPTED---VSGLSLEEQLRRLQ--EERTCKVCMDREVSIV 576

Query: 303 LIPCRHLSLCKDCDGFINVCPVCQMIKTASVEVYLS 338
            IPC HL +C++C   +  CP+C+     +V  +LS
Sbjct: 577 FIPCGHLVVCQECAPSLRKCPICRGTIKGTVRTFLS 612


>BIR3_MOUSE (O08863) Baculoviral IAP repeat-containing protein 3
           (Inhibitor of apoptosis protein 1) (MIAP1) (MIAP-1)
          Length = 600

 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 20/52 (38%), Positives = 31/52 (59%)

Query: 287 ENLSCRACKAKDVSMLLIPCRHLSLCKDCDGFINVCPVCQMIKTASVEVYLS 338
           E   C+ C  ++VS++ IPC HL +CKDC   +  CP+C+     +V  +LS
Sbjct: 549 EERMCKVCMDREVSIVFIPCGHLVVCKDCAPSLRKCPICRGTIKGTVRTFLS 600


>RNGB_DICDI (Q7M3S9) Ring finger protein B (Protein rngB)
          Length = 943

 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 42/205 (20%), Positives = 92/205 (44%), Gaps = 22/205 (10%)

Query: 134 LGDNIRTELDRQQEELDHYIKLQKEQLSRGVRDMKQKHMASLLTSIEKGIVKKLREKEEE 193
           L    + ++D+QQ++     KLQ+EQ  + ++++ +  ++S  +++          K +E
Sbjct: 758 LSQQQQNQIDKQQKQE----KLQQEQQQQQLKNINRLSISSNSSTLSSKDSFYFESKIQE 813

Query: 194 IEN-MNRKNRELAERIKQVA-VEAQNWHYRAKYNESVVNALRNNLQQAISHGVEQGKEGF 251
           + N +  K + + +R  ++   E Q   Y+    +S+ +     L+ +  +G++Q     
Sbjct: 814 LSNQLKEKQQAITDRDNKIKDFENQLNKYKLIGLDSMDHYQLLELESSFHNGLKQ----- 868

Query: 252 GDSEVDDAASYIDPNNFLSIPGAPMKSIHPRYQGMENLSCRACKAKDVSMLLIPCRHLSL 311
               +         N  +S+          + Q  +  SC  C +   +++L+PCRH SL
Sbjct: 869 ----IGSIKDQRYLNRLVSLE-------KEKDQLKDQNSCVICASNPPNIVLLPCRHSSL 917

Query: 312 CKDCDGFINVCPVCQMIKTASVEVY 336
           C DC   +  CP+C+      + +Y
Sbjct: 918 CSDCCSKLTKCPICRSHIENKISIY 942


>BIR4_MOUSE (Q60989) Baculoviral IAP repeat-containing protein 4
           (Inhibitor of apoptosis protein 3) (X-linked inhibitor
           of apoptosis protein) (X-linked IAP) (IAP homolog A)
           (MIAP3) (MIAP-3)
          Length = 496

 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 15/52 (28%), Positives = 31/52 (58%)

Query: 287 ENLSCRACKAKDVSMLLIPCRHLSLCKDCDGFINVCPVCQMIKTASVEVYLS 338
           E   C+ C  ++++++ +PC HL  CK C   ++ CP+C  + T   ++++S
Sbjct: 445 EEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 496


>BIR4_HUMAN (P98170) Baculoviral IAP repeat-containing protein 4
           (Inhibitor of apoptosis protein 3) (X-linked inhibitor
           of apoptosis protein) (X-linked IAP) (IAP-like protein)
           (HILP)
          Length = 497

 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 15/52 (28%), Positives = 31/52 (58%)

Query: 287 ENLSCRACKAKDVSMLLIPCRHLSLCKDCDGFINVCPVCQMIKTASVEVYLS 338
           E   C+ C  ++++++ +PC HL  CK C   ++ CP+C  + T   ++++S
Sbjct: 446 EEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 497


>BIR4_RAT (Q9R0I6) Baculoviral IAP repeat-containing protein 4
           (Inhibitor of apoptosis protein 3) (X-linked inhibitor
           of apoptosis protein) (X-linked IAP) (IAP homolog A)
           (RIAP3) (RIAP-3)
          Length = 496

 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 15/52 (28%), Positives = 31/52 (58%)

Query: 287 ENLSCRACKAKDVSMLLIPCRHLSLCKDCDGFINVCPVCQMIKTASVEVYLS 338
           E   C+ C  ++++++ +PC HL  CK C   ++ CP+C  + T   ++++S
Sbjct: 445 EEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCCTVITFKQKIFMS 496


>IAP_GVCP (P41436) Apoptosis inhibitor IAP
          Length = 275

 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 18/64 (28%), Positives = 33/64 (51%)

Query: 275 PMKSIHPRYQGMENLSCRACKAKDVSMLLIPCRHLSLCKDCDGFINVCPVCQMIKTASVE 334
           P   I    Q  ++  C+ C  ++  +  +PC H+  C  C   ++ CP+C+ I T+ ++
Sbjct: 212 PETKIEKEPQVEDSKLCKICYVEECIVCFVPCGHVVACAKCALSVDKCPMCRKIVTSVLK 271

Query: 335 VYLS 338
           VY S
Sbjct: 272 VYFS 275


>BIR8_GORGO (Q95M71) Baculoviral IAP repeat-containing protein 8
           (Inhibitor of apoptosis-like protein 2) (IAP-like
           protein 2) (ILP-2)
          Length = 236

 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 16/52 (30%), Positives = 28/52 (53%)

Query: 287 ENLSCRACKAKDVSMLLIPCRHLSLCKDCDGFINVCPVCQMIKTASVEVYLS 338
           E   C+ C  + ++++ IPC HL  CK C   ++ CP+C  +      V++S
Sbjct: 185 EEKLCKICMDRHIAVVFIPCGHLVTCKQCAEAVDRCPMCNAVIDFKQRVFMS 236


>IAP1_NPVOP (O10296) Apoptosis inhibitor 1 (IAP-1)
          Length = 275

 Score = 43.5 bits (101), Expect = 8e-04
 Identities = 21/71 (29%), Positives = 34/71 (47%), Gaps = 11/71 (15%)

Query: 272 PGAPMKSIHPRYQGMENLSCRACKAKDVSMLLIPCRHLSLCKDC----DGFINVCPVCQM 327
           PG P     P + G E L C+ C  +    +L+PCRH  +C  C    DG    CP C+ 
Sbjct: 212 PGEPA----PAFAGSEALECKVCLERQRDAVLLPCRHFCVCMQCYFALDG---KCPTCRQ 264

Query: 328 IKTASVEVYLS 338
                ++++++
Sbjct: 265 DVADFIKIFVT 275


>BIR8_PANTR (Q95M72) Baculoviral IAP repeat-containing protein 8
           (Inhibitor of apoptosis-like protein 2) (IAP-like
           protein 2) (ILP-2)
          Length = 236

 Score = 43.5 bits (101), Expect = 8e-04
 Identities = 15/48 (31%), Positives = 27/48 (56%)

Query: 291 CRACKAKDVSMLLIPCRHLSLCKDCDGFINVCPVCQMIKTASVEVYLS 338
           C+ C  + ++++ IPC HL  CK C   ++ CP+C  +      V++S
Sbjct: 189 CKICMDRHIAVVFIPCGHLVTCKQCAEAVDRCPMCSAVIDFKQRVFMS 236


>BIR8_HUMAN (Q96P09) Baculoviral IAP repeat-containing protein 8
           (Inhibitor of apoptosis-like protein 2) (IAP-like
           protein 2) (ILP-2) (Testis-specific inhibitor of
           apoptosis)
          Length = 236

 Score = 43.1 bits (100), Expect = 0.001
 Identities = 16/52 (30%), Positives = 28/52 (53%)

Query: 287 ENLSCRACKAKDVSMLLIPCRHLSLCKDCDGFINVCPVCQMIKTASVEVYLS 338
           E   C+ C  + ++++ IPC HL  CK C   ++ CP+C  +      V++S
Sbjct: 185 EEKLCKICMDRYIAVVFIPCGHLVTCKQCAEAVDRCPMCSAVIDFKQRVFMS 236


>BIR7_HUMAN (Q96CA5) Baculoviral IAP repeat-containing protein 7
           (Kidney inhibitor of apoptosis protein) (KIAP) (Melanoma
           inhibitor of apoptosis protein) (ML-IAP) (Livin)
           (UNQ5800/PRO19607/PRO21344)
          Length = 298

 Score = 43.1 bits (100), Expect = 0.001
 Identities = 17/52 (32%), Positives = 31/52 (58%), Gaps = 1/52 (1%)

Query: 287 ENLSCRACKAKDVSMLLIPCRHLSLCKDCDGFINVCPVCQMIKTASVEVYLS 338
           E  +C+ C  + VS++ +PC HL +C +C   + +CP+C+    + V  +LS
Sbjct: 248 EERTCKVCLDRAVSIVFVPCGHL-VCAECAPGLQLCPICRAPVRSRVRTFLS 298


>IAP2_DROME (Q24307) Apoptosis 2 inhibitor (Inhibitor of apoptosis
           2) (dIAP2) (DIAP) (IAP homolog A) (IAP-like protein)
           (DILP)
          Length = 498

 Score = 41.2 bits (95), Expect = 0.004
 Identities = 15/48 (31%), Positives = 26/48 (53%)

Query: 291 CRACKAKDVSMLLIPCRHLSLCKDCDGFINVCPVCQMIKTASVEVYLS 338
           C+ C  ++V ++ +PC HL+ C  C   +  CP+C+      V  +LS
Sbjct: 451 CKVCLDEEVGVVFLPCGHLATCNQCAPSVANCPMCRADIKGFVRTFLS 498


>M6_STRPY (P08089) M protein, serotype 6 precursor
          Length = 483

 Score = 40.8 bits (94), Expect = 0.005
 Identities = 34/144 (23%), Positives = 65/144 (44%), Gaps = 5/144 (3%)

Query: 111 DERNSSVTSASGSMTAPPSIILSLGDNIRTE---LDRQQEELDHYIKLQKEQLSRGVRDM 167
           D  NS + + +  +T   + +     N+ TE   L  Q + L    K   +Q      + 
Sbjct: 64  DVENSMLQANNDKLTTENNNLTDQNKNLTTENKNLTDQNKNLTTENKNLTDQNKNLTTEN 123

Query: 168 KQ-KHMASLLTSIEKGIVKKLREKEEEIENMNRKNRELAERIKQVAVE-AQNWHYRAKYN 225
           K+ K   + LT+  KG+ KKL E EEE  N  R+N+E    +K+   E  ++   + + +
Sbjct: 124 KELKAEENRLTTENKGLTKKLSEAEEEAANKERENKEAIGTLKKTLDETVKDKIAKEQES 183

Query: 226 ESVVNALRNNLQQAISHGVEQGKE 249
           +  +  L+  L + +   + + +E
Sbjct: 184 KETIGTLKKTLDETVKDKIAKEQE 207


>GEMI_HUMAN (O75496) Geminin
          Length = 209

 Score = 40.8 bits (94), Expect = 0.005
 Identities = 42/163 (25%), Positives = 73/163 (44%), Gaps = 16/163 (9%)

Query: 98  NALSTGLRLSYDDDERNSSVTSASGSMTAPPSIILSLGDNIRTELDRQQEELDHYIKLQ- 156
           N LS GL      ++  +S TS+ G +    S   +LG          QE  D  IK   
Sbjct: 42  NELSAGLSKRKHRNDHLTSTTSSPGVIVPESSENKNLGGVT-------QESFDLMIKENP 94

Query: 157 KEQLSRGVRDMKQKHMASLLTSIEKGIVKKLREKEEEIENMNRKNRELAERIKQVAVEAQ 216
             Q  + V + ++K +   L   EK + K++ +K+ EI  + ++N+ELAE        A+
Sbjct: 95  SSQYWKEVAEKRRKALYEALKENEK-LHKEIEQKDNEIARLKKENKELAE-------VAE 146

Query: 217 NWHYRAKYNESVVNALRNNLQQAISHGVEQGKEGFGDSEVDDA 259
           +  Y A+  E +     +N +   +   +  +E   DS V+D+
Sbjct: 147 HVQYMAELIERLNGEPLDNFESLDNQEFDSEEETVEDSLVEDS 189


>KTN1_HUMAN (Q86UP2) Kinectin (Kinesin receptor) (CG-1 antigen)
          Length = 1357

 Score = 40.4 bits (93), Expect = 0.006
 Identities = 26/119 (21%), Positives = 60/119 (49%), Gaps = 6/119 (5%)

Query: 131  ILSLGDNIRTELDRQQEELDHYIKLQKEQLSRGVRDMKQKHMASLLTSIEKGIVKKLREK 190
            +L+  + I  +L R  E+ ++  K++ ++  + +     K M S  TS E+ + ++LR +
Sbjct: 1142 VLAETEGILQKLQRSVEQEENKWKVKVDESHKTI-----KQMQSSFTSSEQEL-ERLRSE 1195

Query: 191  EEEIENMNRKNRELAERIKQVAVEAQNWHYRAKYNESVVNALRNNLQQAISHGVEQGKE 249
             ++IEN+ R+   L   +++  +E   +    +  + ++  L+  L  + S  V Q +E
Sbjct: 1196 NKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEE 1254



 Score = 30.8 bits (68), Expect = 5.1
 Identities = 22/106 (20%), Positives = 48/106 (44%), Gaps = 4/106 (3%)

Query: 111  DERNSSVTSASGSMTAPPSIILSLGDNIRT--ELDRQQEELDHYIKLQKEQLSRGVRDMK 168
            DE + ++     S T+    +  L    +    L R++E L+  ++L+K ++ R     +
Sbjct: 1169 DESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLE--MELEKAEMERSTYVTE 1226

Query: 169  QKHMASLLTSIEKGIVKKLREKEEEIENMNRKNRELAERIKQVAVE 214
             + +  LLT ++K +     E   + E +N    +L E + ++  E
Sbjct: 1227 VRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTE 1272


  Database: sprot
    Posted date:  Nov 25, 2004 10:54 AM
  Number of letters in database: 59,974,054
  Number of sequences in database:  164,201
  
Lambda     K      H
   0.315    0.131    0.375 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,858,549
Number of Sequences: 164201
Number of extensions: 1611420
Number of successful extensions: 7644
Number of sequences better than 10.0: 334
Number of HSP's better than 10.0 without gapping: 54
Number of HSP's successfully gapped in prelim test: 282
Number of HSP's that attempted gapping in prelim test: 7245
Number of HSP's gapped (non-prelim): 654
length of query: 338
length of database: 59,974,054
effective HSP length: 111
effective length of query: 227
effective length of database: 41,747,743
effective search space: 9476737661
effective search space used: 9476737661
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)