BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= TM0140.12
(414 letters)
Database: nr
2,540,612 sequences; 863,360,394 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
ref|NP_849732.1| cation-chloride cotransporter, putative [Arabid... 689 0.0
gb|AAC49874.1| cation-chloride co-transporter [Nicotiana tabacum... 687 0.0
gb|AAF19744.1| Strong similarity to gb|AF021220 Nicotiana tabacu... 670 0.0
ref|XP_481609.1| putative Na+/K+/Cl-cotransport protein [Oryza s... 668 0.0
dbj|BAD44902.1| putative potassium-chloride cotransporter isofor... 645 0.0
ref|NP_914176.1| putative cation-chloride co-transporter [Oryza ... 512 e-144
gb|AAP84988.1| potassium-chloride cotransporter isoform 4 [Oryct... 295 2e-78
gb|AAM50621.1| GH09271p [Drosophila melanogaster] gi|21626681|gb... 294 4e-78
gb|AAF47099.2| CG5594-PC, isoform C [Drosophila melanogaster] gi... 294 4e-78
gb|AAF47098.2| CG5594-PA, isoform A [Drosophila melanogaster] gi... 294 4e-78
gb|AAM68276.1| CG5594-PD, isoform D [Drosophila melanogaster] gi... 294 4e-78
gb|EAL24809.1| GA18994-PA [Drosophila pseudoobscura] 288 2e-76
ref|NP_999114.1| K-Cl cotransporter [Sus scrofa] gi|7513455|pir|... 286 8e-76
gb|AAF39883.2| Hypothetical protein H16O14.1 [Caenorhabditis ele... 234 3e-60
emb|CAF91145.1| unnamed protein product [Tetraodon nigroviridis] 211 3e-53
gb|AAH21193.1| Solute carrier family 12 (potassium/chloride tran... 209 2e-52
gb|AAQ56590.1| potassium-chloride cotransporter [Ciona intestina... 209 2e-52
gb|AAC39685.1| erythroid K:Cl cotransporter splicing isoform 2 [... 209 2e-52
gb|AAC39684.1| erythroid K:Cl cotransporter splicing isoform 1 [... 209 2e-52
gb|AAC52634.1| furosemide-sensitive K-Cl cotransporter [Rattus n... 207 4e-52
>ref|NP_849732.1| cation-chloride cotransporter, putative [Arabidopsis thaliana]
gi|30691713|ref|NP_174333.2| cation-chloride
cotransporter, putative [Arabidopsis thaliana]
gi|30691718|ref|NP_849731.1| cation-chloride
cotransporter, putative [Arabidopsis thaliana]
Length = 975
Score = 689 bits (1778), Expect = 0.0
Identities = 332/404 (82%), Positives = 370/404 (91%)
Query: 11 IVGMGGIGGTLLLVALCGTCTFLTAISLSAIATNGAMKGGGPYYLIGRALGPEVGVSIGL 70
IVGM GIG L+LV LCG CTFLT ISLSAIATNGAMKGGGPYYLIGRALGPEVG+SIGL
Sbjct: 158 IVGMAGIGQGLVLVFLCGLCTFLTTISLSAIATNGAMKGGGPYYLIGRALGPEVGISIGL 217
Query: 71 CFFLGNAVAGALYVLGAVETFLKAVPAAGIFRETITQVNGTTIAQPIESPSSHDLQIYGI 130
CFFLGNAVAGALYVLGAVETFLKA PAAGIFRETIT+VNGT +++ I+SP+SHDLQ+YGI
Sbjct: 218 CFFLGNAVAGALYVLGAVETFLKAFPAAGIFRETITKVNGTAVSESIQSPNSHDLQVYGI 277
Query: 131 VVTIVLCFIVFGGVKMINRVAPAFLIPVLFSLICIYLGILLAREDHPAEGITGLSLETLK 190
VVTI+LCFIVFGGVKMINRVAPAFL+PVL S+ CI++GI LA+ D P GITGL L++ K
Sbjct: 278 VVTILLCFIVFGGVKMINRVAPAFLVPVLLSIFCIFIGIFLAKTDDPDNGITGLRLKSFK 337
Query: 191 DNWGSEYQKTNDAGIPEPDGSVSWNFNALVGLFFPAVTGIMAGSNRSSSLKDTQRSIPLG 250
DNWGS YQ TNDAGIP+P G W+FN LVGLFFPAVTGIMAGSNRS+SLKDTQ+SIP+G
Sbjct: 338 DNWGSAYQMTNDAGIPDPTGGTYWSFNELVGLFFPAVTGIMAGSNRSASLKDTQKSIPVG 397
Query: 251 TLAATLVTTFMYLVSVIMFGALATREKLLTDRLLTATVAWPFPSLIKIGIILSTMGAALQ 310
TLAATL TT +YL+SV+ FGA+ATR+KLLTDRLLTAT+AWPFP+++ +GIILST+GAALQ
Sbjct: 398 TLAATLTTTSLYLISVLFFGAVATRDKLLTDRLLTATIAWPFPAIVHVGIILSTLGAALQ 457
Query: 311 SLTGAPRLLAAIANDDILPILKYFKVADGSEPHVATLFTAFLCSGCVVIGNLDLITPTVT 370
SLTGAPRLLAAIANDDILPIL YFKVAD SEPH+ATLFTAF+C GCVVIGNLDLITPTVT
Sbjct: 458 SLTGAPRLLAAIANDDILPILNYFKVADTSEPHIATLFTAFICIGCVVIGNLDLITPTVT 517
Query: 371 MFFLLCYAGVNLSCFLLDLLDAPSWRPRWKFHHWSLSLVGALLC 414
MF+LLCY+GVNLSCFLLDLLDAPSWRPRWK+HHWSLS VGA LC
Sbjct: 518 MFYLLCYSGVNLSCFLLDLLDAPSWRPRWKYHHWSLSFVGASLC 561
>gb|AAC49874.1| cation-chloride co-transporter [Nicotiana tabacum]
gi|7489182|pir||T01896 probable Na+/K+/Cl-cotransport
protein - common tobacco
Length = 990
Score = 687 bits (1774), Expect = 0.0
Identities = 330/404 (81%), Positives = 375/404 (92%)
Query: 11 IVGMGGIGGTLLLVALCGTCTFLTAISLSAIATNGAMKGGGPYYLIGRALGPEVGVSIGL 70
IVGM GIG +LLLV CG+CTFLT +SLSAIA+NGAMKGGGPYYLIGRALGPEVGVSIGL
Sbjct: 173 IVGMAGIGESLLLVVFCGSCTFLTTVSLSAIASNGAMKGGGPYYLIGRALGPEVGVSIGL 232
Query: 71 CFFLGNAVAGALYVLGAVETFLKAVPAAGIFRETITQVNGTTIAQPIESPSSHDLQIYGI 130
CFFLGNA+AGA+YVLGAVETFL AVP+AGIFRETIT+VNGT IA+PI SPS HDLQIYGI
Sbjct: 233 CFFLGNAIAGAMYVLGAVETFLNAVPSAGIFRETITRVNGTDIAEPITSPSLHDLQIYGI 292
Query: 131 VVTIVLCFIVFGGVKMINRVAPAFLIPVLFSLICIYLGILLAREDHPAEGITGLSLETLK 190
VV+I+LCF+VFGGVKMINRVAPAFL+PVLFSL+CI++GI AR D PA GITGL+LE+ K
Sbjct: 293 VVSILLCFVVFGGVKMINRVAPAFLVPVLFSLLCIFVGIFSARHDRPAVGITGLNLESFK 352
Query: 191 DNWGSEYQKTNDAGIPEPDGSVSWNFNALVGLFFPAVTGIMAGSNRSSSLKDTQRSIPLG 250
+NWGS YQ TN+AGIP+P+G + W+FNALVGLFFPAVTGIMAGSNRS+SLKDTQRSIP+G
Sbjct: 353 NNWGSSYQMTNNAGIPDPNGKIYWDFNALVGLFFPAVTGIMAGSNRSASLKDTQRSIPVG 412
Query: 251 TLAATLVTTFMYLVSVIMFGALATREKLLTDRLLTATVAWPFPSLIKIGIILSTMGAALQ 310
TLAATL TT +Y+VSV++FGA++TR+KLLTDRLL+ATVAWP P+++ +GIILST+GAALQ
Sbjct: 413 TLAATLTTTGLYVVSVLLFGAVSTRDKLLTDRLLSATVAWPLPAIVYVGIILSTLGAALQ 472
Query: 311 SLTGAPRLLAAIANDDILPILKYFKVADGSEPHVATLFTAFLCSGCVVIGNLDLITPTVT 370
SLTGAPRLLAAIANDDILP+L YFKVADG EPHVATLFTAF+C GCVVIGNLDL++PT T
Sbjct: 473 SLTGAPRLLAAIANDDILPVLNYFKVADGHEPHVATLFTAFICIGCVVIGNLDLVSPTST 532
Query: 371 MFFLLCYAGVNLSCFLLDLLDAPSWRPRWKFHHWSLSLVGALLC 414
MF+L+CYAGVNLS FLLDLLDAPSWRPRWKFHHW LSLVGALLC
Sbjct: 533 MFYLVCYAGVNLSSFLLDLLDAPSWRPRWKFHHWGLSLVGALLC 576
>gb|AAF19744.1| Strong similarity to gb|AF021220 Nicotiana tabacum cation-chloride
co-transporter and contains an amino acid permease
PF|00324 domain. [Arabidopsis thaliana]
gi|25518783|pir||H86428 hypothetical protein F26G16.3
[imported] - Arabidopsis thaliana
Length = 973
Score = 670 bits (1729), Expect = 0.0
Identities = 326/404 (80%), Positives = 364/404 (89%), Gaps = 2/404 (0%)
Query: 11 IVGMGGIGGTLLLVALCGTCTFLTAISLSAIATNGAMKGGGPYYLIGRALGPEVGVSIGL 70
IVGM GIG L+LV LCG CTFLT ISLSAIATNGAMKGGGPYYLIGRALGPEVG+SIGL
Sbjct: 158 IVGMAGIGQGLVLVFLCGLCTFLTTISLSAIATNGAMKGGGPYYLIGRALGPEVGISIGL 217
Query: 71 CFFLGNAVAGALYVLGAVETFLKAVPAAGIFRETITQVNGTTIAQPIESPSSHDLQIYGI 130
CFFLGNAVAGALYVLGAVETFLKA PAAGIFR GT++++ I+SP+SHDLQ+YGI
Sbjct: 218 CFFLGNAVAGALYVLGAVETFLKAFPAAGIFRGI--SYCGTSVSESIQSPNSHDLQVYGI 275
Query: 131 VVTIVLCFIVFGGVKMINRVAPAFLIPVLFSLICIYLGILLAREDHPAEGITGLSLETLK 190
VVTI+LCFIVFGGVKMINRVAPAFL+PVL S+ CI++GI LA+ D P GITGL L++ K
Sbjct: 276 VVTILLCFIVFGGVKMINRVAPAFLVPVLLSIFCIFIGIFLAKTDDPDNGITGLRLKSFK 335
Query: 191 DNWGSEYQKTNDAGIPEPDGSVSWNFNALVGLFFPAVTGIMAGSNRSSSLKDTQRSIPLG 250
DNWGS YQ TNDAGIP+P G W+FN LVGLFFPAVTGIMAGSNRS+SLKDTQ+SIP+G
Sbjct: 336 DNWGSAYQMTNDAGIPDPTGGTYWSFNELVGLFFPAVTGIMAGSNRSASLKDTQKSIPVG 395
Query: 251 TLAATLVTTFMYLVSVIMFGALATREKLLTDRLLTATVAWPFPSLIKIGIILSTMGAALQ 310
TLAATL TT +YL+SV+ FGA+ATR+KLLTDRLLTAT+AWPFP+++ +GIILST+GAALQ
Sbjct: 396 TLAATLTTTSLYLISVLFFGAVATRDKLLTDRLLTATIAWPFPAIVHVGIILSTLGAALQ 455
Query: 311 SLTGAPRLLAAIANDDILPILKYFKVADGSEPHVATLFTAFLCSGCVVIGNLDLITPTVT 370
SLTGAPRLLAAIANDDILPIL YFKVAD SEPH+ATLFTAF+C GCVVIGNLDLITPTVT
Sbjct: 456 SLTGAPRLLAAIANDDILPILNYFKVADTSEPHIATLFTAFICIGCVVIGNLDLITPTVT 515
Query: 371 MFFLLCYAGVNLSCFLLDLLDAPSWRPRWKFHHWSLSLVGALLC 414
MF+LLCY+GVNLSCFLLDLLDAPSWRPRWK+HHWSLS VGA LC
Sbjct: 516 MFYLLCYSGVNLSCFLLDLLDAPSWRPRWKYHHWSLSFVGASLC 559
>ref|XP_481609.1| putative Na+/K+/Cl-cotransport protein [Oryza sativa (japonica
cultivar-group)] gi|38637408|dbj|BAD03666.1| putative
Na+/K+/Cl-cotransport protein [Oryza sativa (japonica
cultivar-group)]
Length = 989
Score = 668 bits (1723), Expect = 0.0
Identities = 324/411 (78%), Positives = 370/411 (89%), Gaps = 7/411 (1%)
Query: 11 IVGMGGIGGTLLLVALCGTCTFLTAISLSAIATNGAMKGGGPYYLIGRALGPEVGVSIGL 70
IVGM G+ +L+LV+ CG CTFLT ISLSAIATNGAMKGGGPYYLIGRALGPEVGVSIGL
Sbjct: 158 IVGMAGVWQSLVLVSFCGACTFLTGISLSAIATNGAMKGGGPYYLIGRALGPEVGVSIGL 217
Query: 71 CFFLGNAVAGALYVLGAVETFLKAVPAAGIFRETITQVNGTTI-------AQPIESPSSH 123
CFFLGNAVAG++YVLGAVETFL AVP+AG F+E++T VN T + I +PS H
Sbjct: 218 CFFLGNAVAGSMYVLGAVETFLDAVPSAGFFKESVTVVNNTLVNGTATASTATISTPSLH 277
Query: 124 DLQIYGIVVTIVLCFIVFGGVKMINRVAPAFLIPVLFSLICIYLGILLAREDHPAEGITG 183
DLQ+YG++VTI+LCFIVFGGVK+IN+VAPAFLIPVLFSL+CIYLG+ +A + +GITG
Sbjct: 278 DLQVYGVIVTILLCFIVFGGVKIINKVAPAFLIPVLFSLLCIYLGVFIAPRHNAPKGITG 337
Query: 184 LSLETLKDNWGSEYQKTNDAGIPEPDGSVSWNFNALVGLFFPAVTGIMAGSNRSSSLKDT 243
LS+ T KDNWGSEYQ+TN+AG+P+P+GS+ W+FNALVGLFFPAVTGIMAGSNRS+SLKDT
Sbjct: 338 LSITTFKDNWGSEYQRTNNAGVPDPNGSIYWDFNALVGLFFPAVTGIMAGSNRSASLKDT 397
Query: 244 QRSIPLGTLAATLVTTFMYLVSVIMFGALATREKLLTDRLLTATVAWPFPSLIKIGIILS 303
QRSIP+GTL+ATL TT MYL SV++FGALATRE+LLTDRLLTATVAWP P++I IGIILS
Sbjct: 398 QRSIPIGTLSATLTTTAMYLFSVLLFGALATREELLTDRLLTATVAWPAPAVIYIGIILS 457
Query: 304 TMGAALQSLTGAPRLLAAIANDDILPILKYFKVADGSEPHVATLFTAFLCSGCVVIGNLD 363
T+GAALQSLTGAPRLLAAIANDDILP+L YFKV++G+EPH ATLFTAF+C CVVIGNLD
Sbjct: 458 TLGAALQSLTGAPRLLAAIANDDILPVLNYFKVSEGAEPHSATLFTAFICICCVVIGNLD 517
Query: 364 LITPTVTMFFLLCYAGVNLSCFLLDLLDAPSWRPRWKFHHWSLSLVGALLC 414
LITPT+TMFFLLCYAGVNLSCFLLDLLDAPSWRPRWKFHHWSLSLVGALLC
Sbjct: 518 LITPTITMFFLLCYAGVNLSCFLLDLLDAPSWRPRWKFHHWSLSLVGALLC 568
>dbj|BAD44902.1| putative potassium-chloride cotransporter isoform 4 [Oryza sativa
(japonica cultivar-group)]
Length = 914
Score = 645 bits (1664), Expect = 0.0
Identities = 310/411 (75%), Positives = 364/411 (88%), Gaps = 7/411 (1%)
Query: 11 IVGMGGIGGTLLLVALCGTCTFLTAISLSAIATNGAMKGGGPYYLIGRALGPEVGVSIGL 70
IVGMGG+ +L+LVA CG+CTFLT ISLSAIATNGAMKGGGPYYLIGRALGPEVGVSIGL
Sbjct: 85 IVGMGGVWQSLVLVAFCGSCTFLTTISLSAIATNGAMKGGGPYYLIGRALGPEVGVSIGL 144
Query: 71 CFFLGNAVAGALYVLGAVETFLKAVPAAGIFRETITQVNGTTI-------AQPIESPSSH 123
CFFLGNAVAGA+YVLGAVETFL AVP+A F+E++T V T + A I +P+ H
Sbjct: 145 CFFLGNAVAGAMYVLGAVETFLDAVPSAEFFQESVTVVTNTFVNGTAAGNATTISTPNLH 204
Query: 124 DLQIYGIVVTIVLCFIVFGGVKMINRVAPAFLIPVLFSLICIYLGILLAREDHPAEGITG 183
DLQ+YGI+VTI+LCFIVFGGVK+IN+VAPAFLIPVLFS++CIY+G+ +A + ++ ITG
Sbjct: 205 DLQVYGIIVTILLCFIVFGGVKIINKVAPAFLIPVLFSILCIYIGVFIAPRPNASKWITG 264
Query: 184 LSLETLKDNWGSEYQKTNDAGIPEPDGSVSWNFNALVGLFFPAVTGIMAGSNRSSSLKDT 243
LS+ TLKDNW S+YQ+TN+AG+P+P+GS+ W+FNAL+GL+FPAVTGIMAGSNRS+SLKDT
Sbjct: 265 LSITTLKDNWSSDYQRTNNAGVPDPNGSIYWDFNALLGLYFPAVTGIMAGSNRSASLKDT 324
Query: 244 QRSIPLGTLAATLVTTFMYLVSVIMFGALATREKLLTDRLLTATVAWPFPSLIKIGIILS 303
QRSIP+GTL AT+ TT MYL+SV +FGAL+TRE LLTDRLL A VAWP P+++ GIILS
Sbjct: 325 QRSIPIGTLHATISTTMMYLLSVFLFGALSTREGLLTDRLLCAAVAWPSPAVVYAGIILS 384
Query: 304 TMGAALQSLTGAPRLLAAIANDDILPILKYFKVADGSEPHVATLFTAFLCSGCVVIGNLD 363
T+GAALQSLTGAPRLLAAIANDDILP+L YFK +GSEPHVATLFT+F+C CV+IGNLD
Sbjct: 385 TLGAALQSLTGAPRLLAAIANDDILPVLNYFKAYEGSEPHVATLFTSFICISCVIIGNLD 444
Query: 364 LITPTVTMFFLLCYAGVNLSCFLLDLLDAPSWRPRWKFHHWSLSLVGALLC 414
+ITPT+TMFFLLCYAGVNLSCFLLDLLDAPSWRPRWK HHWSLSL+GALLC
Sbjct: 445 VITPTITMFFLLCYAGVNLSCFLLDLLDAPSWRPRWKLHHWSLSLIGALLC 495
>ref|NP_914176.1| putative cation-chloride co-transporter [Oryza sativa (japonica
cultivar-group)]
Length = 1270
Score = 512 bits (1319), Expect = e-144
Identities = 262/411 (63%), Positives = 312/411 (75%), Gaps = 56/411 (13%)
Query: 11 IVGMGGIGGTLLLVALCGTCTFLTAISLSAIATNGAMKGGGPYYLIGRALGPEVGVSIGL 70
IVGMGG+ +L+LVA CG+CTFLT ISLSAIATNGAMKGGGPYYLIGRALGPEVGVSIGL
Sbjct: 464 IVGMGGVWQSLVLVAFCGSCTFLTTISLSAIATNGAMKGGGPYYLIGRALGPEVGVSIGL 523
Query: 71 CFFLGNAVAGALYVLGAVETFLKAVPAAGIFRETITQVNGTTI-------AQPIESPSSH 123
CFFLGNAVAGA+YVLGAVETFL AVP+A F+E++T V T + A I +P+ H
Sbjct: 524 CFFLGNAVAGAMYVLGAVETFLDAVPSAEFFQESVTVVTNTFVNGTAAGNATTISTPNLH 583
Query: 124 DLQIYGIVVTIVLCFIVFGGVKMINRVAPAFLIPVLFSLICIYLGILLAREDHPAEGITG 183
DLQ+YGI+VTI+LCFIVFGGVK+IN+VAPAFLIPVLFS++CIY+G+ +A + ++ ITG
Sbjct: 584 DLQVYGIIVTILLCFIVFGGVKIINKVAPAFLIPVLFSILCIYIGVFIAPRPNASKWITG 643
Query: 184 LSLETLKDNWGSEYQKTNDAGIPEPDGSVSWNFNALVGLFFPAVTGIMAGSNRSSSLKDT 243
LS+ TLKDNW S+YQ+TN+AG+P+P+GS+ W+FNAL+GL+FPAVTGIMAGSNRS+SLKDT
Sbjct: 644 LSITTLKDNWSSDYQRTNNAGVPDPNGSIYWDFNALLGLYFPAVTGIMAGSNRSASLKDT 703
Query: 244 QRSIPLGTLAATLVTTFMYLVSVIMFGALATREKLLTDRLLTATVAWPFPSLIKIGIILS 303
QRSIP+GTL AT+ TT MYL+SV +FGAL+TRE LLTD S
Sbjct: 704 QRSIPIGTLHATISTTMMYLLSVFLFGALSTREGLLTD---------------------S 742
Query: 304 TMGAALQSLTGAPRLLAAIANDDILPILKYFKVADGSEPHVATLFTAFLCSGCVVIGNLD 363
T L L ++V + L F+ S CV+IGNLD
Sbjct: 743 TSSNLL---------------------LNQYRV-------LKKLVVDFMLSCCVIIGNLD 774
Query: 364 LITPTVTMFFLLCYAGVNLSCFLLDLLDAPSWRPRWKFHHWSLSLVGALLC 414
+ITPT+TMFFLLCYAGVNLSCFLLDLLDAPSWRPRWK HHWSLSL+GALLC
Sbjct: 775 VITPTITMFFLLCYAGVNLSCFLLDLLDAPSWRPRWKLHHWSLSLIGALLC 825
>gb|AAP84988.1| potassium-chloride cotransporter isoform 4 [Oryctolagus cuniculus]
Length = 1106
Score = 295 bits (755), Expect = 2e-78
Identities = 178/483 (36%), Positives = 257/483 (52%), Gaps = 79/483 (16%)
Query: 11 IVGMGGIGGTLLLVALCGTCTFLTAISLSAIATNGAMKGGGPYYLIGRALGPEVGVSIGL 70
IVG G+ + L+V++C TCT LTA+S+SAIATNG + GG YY+I R+LGPE G ++GL
Sbjct: 168 IVGAAGVLESFLVVSMCCTCTMLTAVSMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGL 227
Query: 71 CFFLGNAVAGALYVLGAVETFLKAV-PAAGIFRETITQVNGTTIAQPIESPSSHDLQIYG 129
CF+LG AGA+Y+LG +E FL + P A +F+ + + + S L +
Sbjct: 228 CFYLGTTFAGAMYILGTIEIFLTYISPGAAVFQAETPEGEAAALLHNMRVYGSCTLALMA 287
Query: 130 IVVTIVLCFI-----------------VFGGV---------------------------- 144
+VV + + ++ ++ GV
Sbjct: 288 VVVFVGVKYVNKLALVFLACVVLSILAIYAGVIKTAFDPPDIPVCLLGNRTLARRGFDTC 347
Query: 145 KMINRVAPAFLIPVLFSLICIYLGILLAREDHPAE-------GITGLSLETLKDNWGSEY 197
+ V+ L+ L C + A ++ A+ GI G++ L DN S Y
Sbjct: 348 AKVRAVSNGTATTALWGLFCNGSSLDTACNEYFAQNNVTEIQGIPGVASGVLLDNLWSAY 407
Query: 198 -------QKTNDAGIPEPD-----------GSVSWNFNALVGLFFPAVTGIMAGSNRSSS 239
+K A +P P+ ++ F LVG++FP+VTGIMAGSNRS
Sbjct: 408 SDRGAFVEKKGVASVPTPEDGRASGLPYVLSDITTYFTVLVGIYFPSVTGIMAGSNRSGD 467
Query: 240 LKDTQRSIPLGTLAATLVTTFMYLVSVIMFGA----LATREKL---LTDRLLTATVAWPF 292
LKD Q+SIP GT+ A + T+F+YL +++FGA + R+K L L+ +AWP
Sbjct: 468 LKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIEGVVLRDKFGEALQGNLVIGMLAWPS 527
Query: 293 PSLIKIGIILSTMGAALQSLTGAPRLLAAIANDDILPILKYFKVADGS-EPHVATLFTAF 351
P +I IG ST GA LQSLTGAPRLL AIA D I+P L+ F + EP A L TA
Sbjct: 528 PWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGIVPFLQVFGHGKANGEPTWALLLTAL 587
Query: 352 LCSGCVVIGNLDLITPTVTMFFLLCYAGVNLSCFLLDLLDAPSWRPRWKFHHWSLSLVGA 411
+C ++I +LD + P ++MFFL+CY VNL+C + LL P+WRPR+K++HW+LS +G
Sbjct: 588 ICETGILIASLDSVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFKYYHWTLSFLGM 647
Query: 412 LLC 414
LC
Sbjct: 648 SLC 650
>gb|AAM50621.1| GH09271p [Drosophila melanogaster] gi|21626681|gb|AAM68277.1|
CG5594-PB, isoform B [Drosophila melanogaster]
gi|24762441|ref|NP_726379.1| CG5594-PB, isoform B
[Drosophila melanogaster]
Length = 1028
Score = 294 bits (752), Expect = 4e-78
Identities = 180/477 (37%), Positives = 255/477 (52%), Gaps = 83/477 (17%)
Query: 11 IVGMGGIGGTLLLVALCGTCTFLTAISLSAIATNGAMKGGGPYYLIGRALGPEVGVSIGL 70
+VG G L+V C T LTAIS+SAIATNG + GG Y++I R+LGPE G ++G+
Sbjct: 120 VVGTAGAVCGFLIVLTCCCVTMLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGM 179
Query: 71 CFFLGNAVAGALYVLGAVETFLKAV-PAAGIFRETITQVNGTTIAQPIESPSSHDLQIYG 129
F+ G +A A+Y++GAVE L + P A IF + + ++ ++YG
Sbjct: 180 LFYTGTTLAAAMYIVGAVEIVLTYMAPWASIFGDFTKDADAMY----------NNFRVYG 229
Query: 130 IVVTIVLCFIVFGGVKMINRVAPAFLIPVLFSLICIYLGIL------------------- 170
++ I + IVF GVK +N+ A L V+ S+I +Y+GI
Sbjct: 230 TLLLIFMGLIVFLGVKFVNKFATVALACVILSIIAVYVGIFDNIHGNEKLYMCVLGKRLL 289
Query: 171 -----------------------------LAREDHPAEGITGLSLETLKDN--------- 192
LA +GI GL+ DN
Sbjct: 290 KDIPLENCTKEDSFLRDIYCPDGKCEEYYLANNVTKVKGIKGLASGVFYDNIFPSFLEKG 349
Query: 193 ----WGS---EYQKTNDAGIPEPDGSVSWNFNALVGLFFPAVTGIMAGSNRSSSLKDTQR 245
+G + + T+ + ++ +F L+G+FFP+VTGIMAGSNRS L D Q+
Sbjct: 350 QFISYGKSAIDIENTSGESYNQIMADITTSFTLLIGIFFPSVTGIMAGSNRSGDLADAQK 409
Query: 246 SIPLGTLAATLVTTFMYLVSVIMFGA----LATREKL---LTDRLLTATVAWPFPSLIKI 298
SIP+GT+ A L T+ +YL SV+ F L R+K + +L+ A +AWP +I I
Sbjct: 410 SIPIGTICAILTTSTVYLSSVMFFAGTVDNLLLRDKFGQSIGGKLVVANIAWPNQWVILI 469
Query: 299 GIILSTMGAALQSLTGAPRLLAAIANDDILPILKYF-KVADGSEPHVATLFTAFLCSGCV 357
G LST+GA LQSLTGAPRLL AIA D+I+P L F K + EP A L T +C +
Sbjct: 470 GSFLSTLGAGLQSLTGAPRLLQAIARDEIIPFLAPFAKSSKRGEPTRALLLTIVICQCGI 529
Query: 358 VIGNLDLITPTVTMFFLLCYAGVNLSCFLLDLLDAPSWRPRWKFHHWSLSLVGALLC 414
++GN+DL+ P ++MFFL+CY VNL+C + LL P+WRPR+KF+HWSLSL+G LC
Sbjct: 530 LLGNVDLLAPLLSMFFLMCYGFVNLACAVQTLLRTPNWRPRFKFYHWSLSLIGLTLC 586
>gb|AAF47099.2| CG5594-PC, isoform C [Drosophila melanogaster]
gi|22026947|ref|NP_571976.2| CG5594-PC, isoform C
[Drosophila melanogaster]
Length = 1059
Score = 294 bits (752), Expect = 4e-78
Identities = 180/477 (37%), Positives = 255/477 (52%), Gaps = 83/477 (17%)
Query: 11 IVGMGGIGGTLLLVALCGTCTFLTAISLSAIATNGAMKGGGPYYLIGRALGPEVGVSIGL 70
+VG G L+V C T LTAIS+SAIATNG + GG Y++I R+LGPE G ++G+
Sbjct: 120 VVGTAGAVCGFLIVLTCCCVTMLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGM 179
Query: 71 CFFLGNAVAGALYVLGAVETFLKAV-PAAGIFRETITQVNGTTIAQPIESPSSHDLQIYG 129
F+ G +A A+Y++GAVE L + P A IF + + ++ ++YG
Sbjct: 180 LFYTGTTLAAAMYIVGAVEIVLTYMAPWASIFGDFTKDADAMY----------NNFRVYG 229
Query: 130 IVVTIVLCFIVFGGVKMINRVAPAFLIPVLFSLICIYLGIL------------------- 170
++ I + IVF GVK +N+ A L V+ S+I +Y+GI
Sbjct: 230 TLLLIFMGLIVFLGVKFVNKFATVALACVILSIIAVYVGIFDNIHGNEKLYMCVLGKRLL 289
Query: 171 -----------------------------LAREDHPAEGITGLSLETLKDN--------- 192
LA +GI GL+ DN
Sbjct: 290 KDIPLENCTKEDSFLRDIYCPDGKCEEYYLANNVTKVKGIKGLASGVFYDNIFPSFLEKG 349
Query: 193 ----WGS---EYQKTNDAGIPEPDGSVSWNFNALVGLFFPAVTGIMAGSNRSSSLKDTQR 245
+G + + T+ + ++ +F L+G+FFP+VTGIMAGSNRS L D Q+
Sbjct: 350 QFISYGKSAIDIENTSGESYNQIMADITTSFTLLIGIFFPSVTGIMAGSNRSGDLADAQK 409
Query: 246 SIPLGTLAATLVTTFMYLVSVIMFGA----LATREKL---LTDRLLTATVAWPFPSLIKI 298
SIP+GT+ A L T+ +YL SV+ F L R+K + +L+ A +AWP +I I
Sbjct: 410 SIPIGTICAILTTSTVYLSSVMFFAGTVDNLLLRDKFGQSIGGKLVVANIAWPNQWVILI 469
Query: 299 GIILSTMGAALQSLTGAPRLLAAIANDDILPILKYF-KVADGSEPHVATLFTAFLCSGCV 357
G LST+GA LQSLTGAPRLL AIA D+I+P L F K + EP A L T +C +
Sbjct: 470 GSFLSTLGAGLQSLTGAPRLLQAIARDEIIPFLAPFAKSSKRGEPTRALLLTIVICQCGI 529
Query: 358 VIGNLDLITPTVTMFFLLCYAGVNLSCFLLDLLDAPSWRPRWKFHHWSLSLVGALLC 414
++GN+DL+ P ++MFFL+CY VNL+C + LL P+WRPR+KF+HWSLSL+G LC
Sbjct: 530 LLGNVDLLAPLLSMFFLMCYGFVNLACAVQTLLRTPNWRPRFKFYHWSLSLIGLTLC 586
>gb|AAF47098.2| CG5594-PA, isoform A [Drosophila melanogaster]
gi|24762439|ref|NP_726378.1| CG5594-PA, isoform A
[Drosophila melanogaster]
Length = 1043
Score = 294 bits (752), Expect = 4e-78
Identities = 180/477 (37%), Positives = 255/477 (52%), Gaps = 83/477 (17%)
Query: 11 IVGMGGIGGTLLLVALCGTCTFLTAISLSAIATNGAMKGGGPYYLIGRALGPEVGVSIGL 70
+VG G L+V C T LTAIS+SAIATNG + GG Y++I R+LGPE G ++G+
Sbjct: 135 VVGTAGAVCGFLIVLTCCCVTMLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGM 194
Query: 71 CFFLGNAVAGALYVLGAVETFLKAV-PAAGIFRETITQVNGTTIAQPIESPSSHDLQIYG 129
F+ G +A A+Y++GAVE L + P A IF + + ++ ++YG
Sbjct: 195 LFYTGTTLAAAMYIVGAVEIVLTYMAPWASIFGDFTKDADAMY----------NNFRVYG 244
Query: 130 IVVTIVLCFIVFGGVKMINRVAPAFLIPVLFSLICIYLGIL------------------- 170
++ I + IVF GVK +N+ A L V+ S+I +Y+GI
Sbjct: 245 TLLLIFMGLIVFLGVKFVNKFATVALACVILSIIAVYVGIFDNIHGNEKLYMCVLGKRLL 304
Query: 171 -----------------------------LAREDHPAEGITGLSLETLKDN--------- 192
LA +GI GL+ DN
Sbjct: 305 KDIPLENCTKEDSFLRDIYCPDGKCEEYYLANNVTKVKGIKGLASGVFYDNIFPSFLEKG 364
Query: 193 ----WGS---EYQKTNDAGIPEPDGSVSWNFNALVGLFFPAVTGIMAGSNRSSSLKDTQR 245
+G + + T+ + ++ +F L+G+FFP+VTGIMAGSNRS L D Q+
Sbjct: 365 QFISYGKSAIDIENTSGESYNQIMADITTSFTLLIGIFFPSVTGIMAGSNRSGDLADAQK 424
Query: 246 SIPLGTLAATLVTTFMYLVSVIMFGA----LATREKL---LTDRLLTATVAWPFPSLIKI 298
SIP+GT+ A L T+ +YL SV+ F L R+K + +L+ A +AWP +I I
Sbjct: 425 SIPIGTICAILTTSTVYLSSVMFFAGTVDNLLLRDKFGQSIGGKLVVANIAWPNQWVILI 484
Query: 299 GIILSTMGAALQSLTGAPRLLAAIANDDILPILKYF-KVADGSEPHVATLFTAFLCSGCV 357
G LST+GA LQSLTGAPRLL AIA D+I+P L F K + EP A L T +C +
Sbjct: 485 GSFLSTLGAGLQSLTGAPRLLQAIARDEIIPFLAPFAKSSKRGEPTRALLLTIVICQCGI 544
Query: 358 VIGNLDLITPTVTMFFLLCYAGVNLSCFLLDLLDAPSWRPRWKFHHWSLSLVGALLC 414
++GN+DL+ P ++MFFL+CY VNL+C + LL P+WRPR+KF+HWSLSL+G LC
Sbjct: 545 LLGNVDLLAPLLSMFFLMCYGFVNLACAVQTLLRTPNWRPRFKFYHWSLSLIGLTLC 601
>gb|AAM68276.1| CG5594-PD, isoform D [Drosophila melanogaster]
gi|24762437|ref|NP_726377.1| CG5594-PD, isoform D
[Drosophila melanogaster] gi|46409210|gb|AAS93762.1|
LD02554p [Drosophila melanogaster]
Length = 1074
Score = 294 bits (752), Expect = 4e-78
Identities = 180/477 (37%), Positives = 255/477 (52%), Gaps = 83/477 (17%)
Query: 11 IVGMGGIGGTLLLVALCGTCTFLTAISLSAIATNGAMKGGGPYYLIGRALGPEVGVSIGL 70
+VG G L+V C T LTAIS+SAIATNG + GG Y++I R+LGPE G ++G+
Sbjct: 135 VVGTAGAVCGFLIVLTCCCVTMLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGM 194
Query: 71 CFFLGNAVAGALYVLGAVETFLKAV-PAAGIFRETITQVNGTTIAQPIESPSSHDLQIYG 129
F+ G +A A+Y++GAVE L + P A IF + + ++ ++YG
Sbjct: 195 LFYTGTTLAAAMYIVGAVEIVLTYMAPWASIFGDFTKDADAMY----------NNFRVYG 244
Query: 130 IVVTIVLCFIVFGGVKMINRVAPAFLIPVLFSLICIYLGIL------------------- 170
++ I + IVF GVK +N+ A L V+ S+I +Y+GI
Sbjct: 245 TLLLIFMGLIVFLGVKFVNKFATVALACVILSIIAVYVGIFDNIHGNEKLYMCVLGKRLL 304
Query: 171 -----------------------------LAREDHPAEGITGLSLETLKDN--------- 192
LA +GI GL+ DN
Sbjct: 305 KDIPLENCTKEDSFLRDIYCPDGKCEEYYLANNVTKVKGIKGLASGVFYDNIFPSFLEKG 364
Query: 193 ----WGS---EYQKTNDAGIPEPDGSVSWNFNALVGLFFPAVTGIMAGSNRSSSLKDTQR 245
+G + + T+ + ++ +F L+G+FFP+VTGIMAGSNRS L D Q+
Sbjct: 365 QFISYGKSAIDIENTSGESYNQIMADITTSFTLLIGIFFPSVTGIMAGSNRSGDLADAQK 424
Query: 246 SIPLGTLAATLVTTFMYLVSVIMFGA----LATREKL---LTDRLLTATVAWPFPSLIKI 298
SIP+GT+ A L T+ +YL SV+ F L R+K + +L+ A +AWP +I I
Sbjct: 425 SIPIGTICAILTTSTVYLSSVMFFAGTVDNLLLRDKFGQSIGGKLVVANIAWPNQWVILI 484
Query: 299 GIILSTMGAALQSLTGAPRLLAAIANDDILPILKYF-KVADGSEPHVATLFTAFLCSGCV 357
G LST+GA LQSLTGAPRLL AIA D+I+P L F K + EP A L T +C +
Sbjct: 485 GSFLSTLGAGLQSLTGAPRLLQAIARDEIIPFLAPFAKSSKRGEPTRALLLTIVICQCGI 544
Query: 358 VIGNLDLITPTVTMFFLLCYAGVNLSCFLLDLLDAPSWRPRWKFHHWSLSLVGALLC 414
++GN+DL+ P ++MFFL+CY VNL+C + LL P+WRPR+KF+HWSLSL+G LC
Sbjct: 545 LLGNVDLLAPLLSMFFLMCYGFVNLACAVQTLLRTPNWRPRFKFYHWSLSLIGLTLC 601
>gb|EAL24809.1| GA18994-PA [Drosophila pseudoobscura]
Length = 1068
Score = 288 bits (737), Expect = 2e-76
Identities = 185/477 (38%), Positives = 257/477 (53%), Gaps = 83/477 (17%)
Query: 11 IVGMGGIGGTLLLVALCGTCTFLTAISLSAIATNGAMKGGGPYYLIGRALGPEVGVSIGL 70
+VG G L+V C T LTAIS+SAIATNG + GG Y++I R+LGPE G ++G+
Sbjct: 141 VVGTAGAICGFLIVLTCCCVTMLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGM 200
Query: 71 CFFLGNAVAGALYVLGAVETFLKAV-PAAGIFRETITQVNGTTIAQPIESPSSHDLQIYG 129
F+ G +A A+Y++GAVE L + P A IF + + ++ ++YG
Sbjct: 201 LFYTGTTLAAAMYIVGAVEIVLTYMAPWASIFGDFTKDADAMY----------NNFRVYG 250
Query: 130 IVVTIVLCFIVFGGVKMINRVAPAFLIPVLFSLICI--------------YLGILLAR-- 173
V+ I + IVF GVK +N+ A L V+ S+I + Y+ +L R
Sbjct: 251 TVLLIFMGLIVFVGVKFVNKFATVALACVILSIIAVYVGIFDNIHGNEKLYMCVLGKRLL 310
Query: 174 EDHPAE--------------------------------GITGLSLETLKDNW-------G 194
+D P + GI GL+ DN G
Sbjct: 311 KDIPIDNCTKDDSFMRDIYCPNNRCDDYYLNNNVSKVKGIKGLASGVFYDNIFPSFLEKG 370
Query: 195 SEYQKTNDAGIPEPDGSVSWN---------FNALVGLFFPAVTGIMAGSNRSSSLKDTQR 245
+D+ E G+ S+N F L+G+FFP+VTGIMAGSNRS L D Q+
Sbjct: 371 QLISYGHDSIDIENIGNESYNQIMADITTTFTLLIGIFFPSVTGIMAGSNRSGDLADAQK 430
Query: 246 SIPLGTLAATLVTTFMYLVSVIMFGA----LATREKL---LTDRLLTATVAWPFPSLIKI 298
SIP+GT+ A L T+ +YL SV+ F L R+K + +L+ A +AWP +I I
Sbjct: 431 SIPIGTICAILTTSTVYLSSVLFFAGTVDNLLLRDKFGQSIGGKLVVANIAWPNQWVILI 490
Query: 299 GIILSTMGAALQSLTGAPRLLAAIANDDILPILKYF-KVADGSEPHVATLFTAFLCSGCV 357
G LST+GA LQSLTGAPRLL AIA D+I+P L F K + EP A L T +C +
Sbjct: 491 GSFLSTLGAGLQSLTGAPRLLQAIARDEIIPFLAPFAKSSKRGEPTRALLLTIVICQCGI 550
Query: 358 VIGNLDLITPTVTMFFLLCYAGVNLSCFLLDLLDAPSWRPRWKFHHWSLSLVGALLC 414
++GN+DL+ P ++MFFL+CY VNL+C + LL P+WRPR+KF+HWSLSL+G LC
Sbjct: 551 LLGNVDLLAPLLSMFFLMCYGFVNLACAVQTLLRTPNWRPRFKFYHWSLSLIGLTLC 607
>ref|NP_999114.1| K-Cl cotransporter [Sus scrofa] gi|7513455|pir||T14114 K-Cl
cotransport protein - pig gi|2599467|gb|AAB84137.1| K-Cl
cotransporter [Sus scrofa]
Length = 1086
Score = 286 bits (732), Expect = 8e-76
Identities = 182/491 (37%), Positives = 257/491 (52%), Gaps = 95/491 (19%)
Query: 11 IVGMGGIGGTLLLVALCGTCTFLTAISLSAIATNGAMKGGGPYYLIGRALGPEVGVSIGL 70
+VG G+ LL+V +C CT LTAIS+SAIATNG + GG Y++I R+LGPE G ++GL
Sbjct: 144 MVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGL 203
Query: 71 CFFLGNAVAGALYVLGAVETFLKAV-PAAGIFRETITQVNGTTIAQPIESPSSHDLQIYG 129
CF+LG A A+Y+LGA+E L + P A IF T T S + +++++YG
Sbjct: 204 CFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPTGTH--------DTSSATLNNMRVYG 255
Query: 130 IV--------------------------VTIVLCFIVFGGVKMI------------NRVA 151
+ V I + I GG+K I NR
Sbjct: 256 TIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTL 315
Query: 152 PAFLIPV---------------LFSLICIYLGI--------LLAREDHPAEGITGLSLET 188
V L+SL C + L GI G +
Sbjct: 316 SRDQFDVCAKTVMVDNETVTTRLWSLFCHSPNLTADSCDPYFLLNNVTEIPGIPGAAASV 375
Query: 189 LKDNWGSEYQKTNDA----GIPEPDG-------------SVSWNFNALVGLFFPAVTGIM 231
L++N S Y + + G+P D ++ +F LVG+FFP+VTGIM
Sbjct: 376 LQENLWSAYLEKGEVVEKHGLPSTDALGLKESLPLYVVADIATSFTVLVGIFFPSVTGIM 435
Query: 232 AGSNRSSSLKDTQRSIPLGTLAATLVTTFMYLVSVIMFGA----LATREKL---LTDRLL 284
AGSNRS L+D Q+SIP+GT+ A + T+ +Y SV++FGA + R+K ++ L+
Sbjct: 436 AGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLV 495
Query: 285 TATVAWPFPSLIKIGIILSTMGAALQSLTGAPRLLAAIANDDILPILKYFKVADGS-EPH 343
T+AWP P +I IG ST GA LQSLTGAPRLL AIA D+I+P L+ F + EP
Sbjct: 496 VGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKANGEPT 555
Query: 344 VATLFTAFLCSGCVVIGNLDLITPTVTMFFLLCYAGVNLSCFLLDLLDAPSWRPRWKFHH 403
A L TA + ++I +LD++ P ++MFFL+CY VNL+C + LL P+WRPR+K++H
Sbjct: 556 WALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYH 615
Query: 404 WSLSLVGALLC 414
W+LS +G LC
Sbjct: 616 WALSFLGMSLC 626
>gb|AAF39883.2| Hypothetical protein H16O14.1 [Caenorhabditis elegans]
gi|25149428|ref|NP_500910.2| solute carrier family 12
member, possibly N-myristoylated (4G837) [Caenorhabditis
elegans]
Length = 977
Score = 234 bits (598), Expect = 3e-60
Identities = 164/478 (34%), Positives = 235/478 (48%), Gaps = 75/478 (15%)
Query: 11 IVGMGGIGGTLLLVALCGTCTFLTAISLSAIATNGAMKGGGPYYLI----GRALGPEV-- 64
I+G G+ +V C + TFLT+ISLSAIATNG + GGPYY+I G LG V
Sbjct: 27 IIGTAGVFQAFFVVLTCVSVTFLTSISLSAIATNGVVPSGGPYYMISRNLGPELGGAVGI 86
Query: 65 ----GVSIGLCFFLGNAVAGAL-YVLGAVETFLKAVPAAGIFRETITQVNGTTIAQPIES 119
G +I ++ A+ L Y+ + F + + + G + ++
Sbjct: 87 LFYLGTTIAASMYITGAIEILLLYIYPQAKLFDDIYHNFRVLGTVLLLILGLIVMAGVKF 146
Query: 120 PSSHDLQIYGIVVTIVLC-----FIVFGGVKMIN------------------RVAPAFLI 156
+ L + +V+ +L F+ + G + +V P
Sbjct: 147 VNRCALPLVIVVILCILSAILGVFVRYDGSDSLKFCMVGDRPVDLSTYFEKTQVQPNCTA 206
Query: 157 PVLFSLICIYLGILLAREDH------------PA----EGITGLSLETLKDNWGSEYQKT 200
L L C G D PA I G++ DN +Y +
Sbjct: 207 DGLQDLFCSTNGTCDHYYDRMKNIKVWKSSGMPAIREERAIKGIASGVFFDNLWPKYLRA 266
Query: 201 N--------DAGIPEPDGSVSW-------NFNALVGLFFPAVTGIMAGSNRSSSLKDTQR 245
D G G S+ NF LVG+FFP+ TGIMAGSNRS +L+D +
Sbjct: 267 GEVLSKDRKDKGDLNRGGHPSYIYAESVTNFMILVGVFFPSATGIMAGSNRSGNLRDAAK 326
Query: 246 SIPLGTLAATLVTTFMYLVSVIMFGALATREKLLTDR--------LLTATVAWPFPSLIK 297
SIPLGTLAA ++F+YL+ V++FGA + E + D+ L+ + ++WPFP +I
Sbjct: 327 SIPLGTLAAQNFSSFIYLLGVVLFGA-SVSEMFIRDKYGRSAMGKLIISEISWPFPQVIL 385
Query: 298 IGIILSTMGAALQSLTGAPRLLAAIANDDILPILKYFKVADG-SEPHVATLFTAFLCSGC 356
G +ST GA +QSLTGAPRLL AIA DD+LP LK F+ D EP A L T +C
Sbjct: 386 FGCFMSTAGAGMQSLTGAPRLLQAIAADDVLPFLKPFRKMDSRGEPIRAILLTLAICECG 445
Query: 357 VVIGNLDLITPTVTMFFLLCYAGVNLSCFLLDLLDAPSWRPRWKFHHWSLSLVGALLC 414
++I ++ IT +T FFL+CY GVN +C L LL +P WRP +++ HWSLS++GA+LC
Sbjct: 446 ILIAVIENITALITQFFLMCYLGVNAACALQSLLKSPGWRPGFRYFHWSLSMIGAILC 503
>emb|CAF91145.1| unnamed protein product [Tetraodon nigroviridis]
Length = 1211
Score = 211 bits (538), Expect = 3e-53
Identities = 116/261 (44%), Positives = 160/261 (60%), Gaps = 25/261 (9%)
Query: 179 EGITGLSLETLKDNWGSEYQKTND--------AGIPEPDGS---------VSWNFNALVG 221
+GI GL+ + +N S Y + A P S ++ +F LVG
Sbjct: 448 QGIPGLASSIISENLWSSYLSKGEVVEKGSIQASDEAPPASTHHPYVFADITTSFTLLVG 507
Query: 222 LFFPAVTGIMAGSNRSSSLKDTQRSIPLGTLAATLVTTFMYLVSVIMFGA----LATREK 277
+FFP+VTGIMAGSNRS LKD QRSIP+GT+ A L T+ +YL SV++FGA + R+K
Sbjct: 508 IFFPSVTGIMAGSNRSGDLKDAQRSIPIGTILAILTTSIVYLSSVVLFGACIDGVVLRDK 567
Query: 278 L---LTDRLLTATVAWPFPSLIKIGIILSTMGAALQSLTGAPRLLAAIANDDILPILKYF 334
+ L+ T+AWP P +I +G ST GA LQSLTGAPRLL AIA D+++P L+ F
Sbjct: 568 FGDSVKGNLVVGTLAWPSPWVIVVGSFFSTCGAGLQSLTGAPRLLQAIAKDNVIPFLRVF 627
Query: 335 KVADGS-EPHVATLFTAFLCSGCVVIGNLDLITPTVTMFFLLCYAGVNLSCFLLDLLDAP 393
+ EP A L TA + ++I +LDL+ P +TMFFL+CY VNL+C L LL P
Sbjct: 628 GHGKANGEPTWALLLTALIAELGILIASLDLVAPILTMFFLMCYLFVNLACALQTLLRTP 687
Query: 394 SWRPRWKFHHWSLSLVGALLC 414
+WRPR+ ++HW+LS +G ++C
Sbjct: 688 NWRPRFSYYHWTLSFLGMMIC 708
Score = 133 bits (335), Expect = 9e-30
Identities = 67/163 (41%), Positives = 103/163 (63%), Gaps = 9/163 (5%)
Query: 11 IVGMGGIGGTLLLVALCGTCTFLTAISLSAIATNGAMKGGGPYYLIGRALGPEVGVSIGL 70
+VG G+ L +V +C CT LTAIS+SAIATNG + GG Y++I R+LGPE G ++GL
Sbjct: 197 VVGNAGVLQGLCIVFICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGL 256
Query: 71 CFFLGNAVAGALYVLGAVETFLKAV-PAAGIFRETITQVNGTTIAQPIESPSSHDLQIYG 129
CF+LG AGA+Y+LGA+E L + P A IF + G + +++++YG
Sbjct: 257 CFYLGTTFAGAMYILGAIEILLMYIAPKAAIFEPKHPEGEGAAML--------NNMRVYG 308
Query: 130 IVVTIVLCFIVFGGVKMINRVAPAFLIPVLFSLICIYLGILLA 172
+ +++ +VF GVK +N++A FL V+ S++ IY G L++
Sbjct: 309 SICLLLMSLLVFVGVKYVNKLASIFLACVIISIVSIYAGALVS 351
>gb|AAH21193.1| Solute carrier family 12 (potassium/chloride transporters), member
4 [Homo sapiens] gi|27151691|sp|Q9UP95|S12A4_HUMAN
Solute carrier family 12, member 4 (Electroneutral
potassium-chloride cotransporter 1) (Erythroid K-Cl
cotransporter 1) (hKCC1) gi|1399212|gb|AAC50563.1| K-Cl
cotransporter gi|2921847|gb|AAC32815.1| erythroid K:Cl
cotransporter [Homo sapiens] gi|4827006|ref|NP_005063.1|
solute carrier family 12 (potassium/chloride
transporters), member 4 [Homo sapiens]
Length = 1085
Score = 209 bits (531), Expect = 2e-52
Identities = 114/260 (43%), Positives = 160/260 (60%), Gaps = 25/260 (9%)
Query: 180 GITGLSLETLKDNWGSEYQKTNDA----GIPEPDG-------------SVSWNFNALVGL 222
GI G + L++N S Y + D G+P D ++ +F LVG+
Sbjct: 367 GIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATSFTVLVGI 426
Query: 223 FFPAVTGIMAGSNRSSSLKDTQRSIPLGTLAATLVTTFMYLVSVIMFGA----LATREKL 278
FFP+VTGIMAGSNRS L+D Q+SIP+GT+ A + T+ +Y SV++FGA + R+K
Sbjct: 427 FFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKY 486
Query: 279 ---LTDRLLTATVAWPFPSLIKIGIILSTMGAALQSLTGAPRLLAAIANDDILPILKYFK 335
++ L+ T+AWP P +I IG ST GA LQSLTGAPRLL AIA D+I+P L+ F
Sbjct: 487 GDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFG 546
Query: 336 VAD-GSEPHVATLFTAFLCSGCVVIGNLDLITPTVTMFFLLCYAGVNLSCFLLDLLDAPS 394
EP A L TA + ++I +LD++ P ++MFFL+CY VNL+C + LL P+
Sbjct: 547 HGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPN 606
Query: 395 WRPRWKFHHWSLSLVGALLC 414
WRPR+K++HW+LS +G LC
Sbjct: 607 WRPRFKYYHWALSFLGMSLC 626
Score = 130 bits (327), Expect = 8e-29
Identities = 71/180 (39%), Positives = 106/180 (58%), Gaps = 9/180 (5%)
Query: 11 IVGMGGIGGTLLLVALCGTCTFLTAISLSAIATNGAMKGGGPYYLIGRALGPEVGVSIGL 70
+VG G+ LL+V +C CT LTAIS+SAIATNG + GG Y++I R+LGPE G ++GL
Sbjct: 144 MVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGL 203
Query: 71 CFFLGNAVAGALYVLGAVETFLKAV-PAAGIFRETITQVNGTTIAQPIESPSSHDLQIYG 129
CF+LG A A+Y+LGA+E L + P A IF + A + + +++++YG
Sbjct: 204 CFYLGTTFAAAMYILGAIEILLTYIAPPAAIFY--------PSGAHDTSNATLNNMRVYG 255
Query: 130 IVVTIVLCFIVFGGVKMINRVAPAFLIPVLFSLICIYLGILLAREDHPAEGITGLSLETL 189
+ + +VF GVK +N+ A FL V+ S++ IY G + + D P + L TL
Sbjct: 256 TIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTL 315
>gb|AAQ56590.1| potassium-chloride cotransporter [Ciona intestinalis]
Length = 1160
Score = 209 bits (531), Expect = 2e-52
Identities = 117/266 (43%), Positives = 159/266 (58%), Gaps = 30/266 (11%)
Query: 179 EGITGLSLETLKDNWGSEYQKTN--------------DAGIPE-PDGSVSW-------NF 216
+G+ G++ KDN S Y D P+ P G +W +F
Sbjct: 377 KGVPGIASTVHKDNAMSHYLSAGAPITTDRLSEVPAADVQPPQLPTGYRTWLVADVSSSF 436
Query: 217 NALVGLFFPAVTGIMAGSNRSSSLKDTQRSIPLGTLAATLVTTFMYLVSVIMFGALAT-- 274
L+ +FFP+VTGIMAGSNRS L D QRSIP GT+ A L T F+YL SV+ FG +
Sbjct: 437 TILLAIFFPSVTGIMAGSNRSGDLADAQRSIPKGTIGAVLTTAFIYLSSVVFFGMVVDGA 496
Query: 275 --REKL---LTDRLLTATVAWPFPSLIKIGIILSTMGAALQSLTGAPRLLAAIANDDILP 329
R+K + + L+ + +AWP ++ IG LST+GA LQSLTGAPRLL AIA D+I+P
Sbjct: 497 LLRDKFGDSIGNELIVSIIAWPTKWVVLIGAFLSTVGAGLQSLTGAPRLLQAIAKDNIIP 556
Query: 330 ILKYFKVAD-GSEPHVATLFTAFLCSGCVVIGNLDLITPTVTMFFLLCYAGVNLSCFLLD 388
LK F +P A L T F+ ++I +LD++ P +TMFFL+CY VNL+C L
Sbjct: 557 FLKVFGRGKLNGDPTWALLLTCFISLIGIIIADLDVVAPIITMFFLMCYMFVNLACALQT 616
Query: 389 LLDAPSWRPRWKFHHWSLSLVGALLC 414
LL+ P+WRPR+KF+HW+LS VG ++C
Sbjct: 617 LLNTPNWRPRFKFYHWTLSFVGMIMC 642
Score = 116 bits (290), Expect = 1e-24
Identities = 63/165 (38%), Positives = 94/165 (56%), Gaps = 17/165 (10%)
Query: 11 IVGMGGIGGTLLLVALCGTCTFLTAISLSAIATNGAMKGGGPYYLIGRALGPEVGVSIGL 70
IVG+ GI + +V LC T LT+IS+SAIATNG + GG Y++I RALGPE G ++G+
Sbjct: 148 IVGLAGIMESFFIVLLCCVTTLLTSISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGI 207
Query: 71 CFFLGNAVAGALYVLGAVETFLKAVPAAGIFRETITQVNGTTIAQPIESPSS-----HDL 125
F+LG A ++Y+LGAVE L + T+ P P + ++
Sbjct: 208 LFYLGTTFASSMYILGAVEILLNYIAPV------------ITLFGPFTGPENRGALLNNF 255
Query: 126 QIYGIVVTIVLCFIVFGGVKMINRVAPAFLIPVLFSLICIYLGIL 170
++YG I++ +VF GVK +N+ A FL V+ S++ IY G +
Sbjct: 256 RVYGSCFLILMSTLVFVGVKYVNKFASLFLACVVISILSIYAGAI 300
>gb|AAC39685.1| erythroid K:Cl cotransporter splicing isoform 2 [Homo sapiens]
Length = 1068
Score = 209 bits (531), Expect = 2e-52
Identities = 114/260 (43%), Positives = 160/260 (60%), Gaps = 25/260 (9%)
Query: 180 GITGLSLETLKDNWGSEYQKTNDA----GIPEPDG-------------SVSWNFNALVGL 222
GI G + L++N S Y + D G+P D ++ +F LVG+
Sbjct: 367 GIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATSFTVLVGI 426
Query: 223 FFPAVTGIMAGSNRSSSLKDTQRSIPLGTLAATLVTTFMYLVSVIMFGA----LATREKL 278
FFP+VTGIMAGSNRS L+D Q+SIP+GT+ A + T+ +Y SV++FGA + R+K
Sbjct: 427 FFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKY 486
Query: 279 ---LTDRLLTATVAWPFPSLIKIGIILSTMGAALQSLTGAPRLLAAIANDDILPILKYFK 335
++ L+ T+AWP P +I IG ST GA LQSLTGAPRLL AIA D+I+P L+ F
Sbjct: 487 GDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFG 546
Query: 336 VAD-GSEPHVATLFTAFLCSGCVVIGNLDLITPTVTMFFLLCYAGVNLSCFLLDLLDAPS 394
EP A L TA + ++I +LD++ P ++MFFL+CY VNL+C + LL P+
Sbjct: 547 HGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPN 606
Query: 395 WRPRWKFHHWSLSLVGALLC 414
WRPR+K++HW+LS +G LC
Sbjct: 607 WRPRFKYYHWALSFLGMSLC 626
Score = 130 bits (327), Expect = 8e-29
Identities = 71/180 (39%), Positives = 106/180 (58%), Gaps = 9/180 (5%)
Query: 11 IVGMGGIGGTLLLVALCGTCTFLTAISLSAIATNGAMKGGGPYYLIGRALGPEVGVSIGL 70
+VG G+ LL+V +C CT LTAIS+SAIATNG + GG Y++I R+LGPE G ++GL
Sbjct: 144 MVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGL 203
Query: 71 CFFLGNAVAGALYVLGAVETFLKAV-PAAGIFRETITQVNGTTIAQPIESPSSHDLQIYG 129
CF+LG A A+Y+LGA+E L + P A IF + A + + +++++YG
Sbjct: 204 CFYLGTTFAAAMYILGAIEILLTYIAPPAAIFY--------PSGAHDTSNATLNNMRVYG 255
Query: 130 IVVTIVLCFIVFGGVKMINRVAPAFLIPVLFSLICIYLGILLAREDHPAEGITGLSLETL 189
+ + +VF GVK +N+ A FL V+ S++ IY G + + D P + L TL
Sbjct: 256 TIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTL 315
>gb|AAC39684.1| erythroid K:Cl cotransporter splicing isoform 1 [Homo sapiens]
Length = 1011
Score = 209 bits (531), Expect = 2e-52
Identities = 114/260 (43%), Positives = 160/260 (60%), Gaps = 25/260 (9%)
Query: 180 GITGLSLETLKDNWGSEYQKTNDA----GIPEPDG-------------SVSWNFNALVGL 222
GI G + L++N S Y + D G+P D ++ +F LVG+
Sbjct: 367 GIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATSFTVLVGI 426
Query: 223 FFPAVTGIMAGSNRSSSLKDTQRSIPLGTLAATLVTTFMYLVSVIMFGA----LATREKL 278
FFP+VTGIMAGSNRS L+D Q+SIP+GT+ A + T+ +Y SV++FGA + R+K
Sbjct: 427 FFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKY 486
Query: 279 ---LTDRLLTATVAWPFPSLIKIGIILSTMGAALQSLTGAPRLLAAIANDDILPILKYFK 335
++ L+ T+AWP P +I IG ST GA LQSLTGAPRLL AIA D+I+P L+ F
Sbjct: 487 GDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFG 546
Query: 336 VAD-GSEPHVATLFTAFLCSGCVVIGNLDLITPTVTMFFLLCYAGVNLSCFLLDLLDAPS 394
EP A L TA + ++I +LD++ P ++MFFL+CY VNL+C + LL P+
Sbjct: 547 HGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPN 606
Query: 395 WRPRWKFHHWSLSLVGALLC 414
WRPR+K++HW+LS +G LC
Sbjct: 607 WRPRFKYYHWALSFLGMSLC 626
Score = 130 bits (327), Expect = 8e-29
Identities = 71/180 (39%), Positives = 106/180 (58%), Gaps = 9/180 (5%)
Query: 11 IVGMGGIGGTLLLVALCGTCTFLTAISLSAIATNGAMKGGGPYYLIGRALGPEVGVSIGL 70
+VG G+ LL+V +C CT LTAIS+SAIATNG + GG Y++I R+LGPE G ++GL
Sbjct: 144 MVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGL 203
Query: 71 CFFLGNAVAGALYVLGAVETFLKAV-PAAGIFRETITQVNGTTIAQPIESPSSHDLQIYG 129
CF+LG A A+Y+LGA+E L + P A IF + A + + +++++YG
Sbjct: 204 CFYLGTTFAAAMYILGAIEILLTYIAPPAAIFY--------PSGAHDTSNATLNNMRVYG 255
Query: 130 IVVTIVLCFIVFGGVKMINRVAPAFLIPVLFSLICIYLGILLAREDHPAEGITGLSLETL 189
+ + +VF GVK +N+ A FL V+ S++ IY G + + D P + L TL
Sbjct: 256 TIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTL 315
>gb|AAC52634.1| furosemide-sensitive K-Cl cotransporter [Rattus norvegicus]
gi|27151681|sp|Q63632|S12A4_RAT Solute carrier family
12, member 4 (Electroneutral potassium-chloride
cotransporter 1) (Erythroid K-Cl cotransporter 1)
(rKCC1) (Furosemide-sensitive K-Cl cotransporter)
gi|9507107|ref|NP_062102.1| solute carrier family 12,
member 4 [Rattus norvegicus]
Length = 1085
Score = 207 bits (528), Expect = 4e-52
Identities = 113/260 (43%), Positives = 161/260 (61%), Gaps = 25/260 (9%)
Query: 180 GITGLSLETLKDNWGSEYQKTNDA----GIPEPD-------------GSVSWNFNALVGL 222
GI G + L++N S Y + + G+P D ++ +F LVG+
Sbjct: 367 GIPGAAAGVLQENLWSAYLEKGEVVEKHGLPSTDTLGLKESLSLYVVADIATSFTVLVGI 426
Query: 223 FFPAVTGIMAGSNRSSSLKDTQRSIPLGTLAATLVTTFMYLVSVIMFGA----LATREKL 278
FFP+VTGIMAGSNRS L+D Q+SIP+GT+ A + T+ +Y SVI+FGA + R+K
Sbjct: 427 FFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIVTTSLVYFSSVILFGACIEGVVLRDKY 486
Query: 279 ---LTDRLLTATVAWPFPSLIKIGIILSTMGAALQSLTGAPRLLAAIANDDILPILKYFK 335
++ L+ T+AWP P +I +G ST GA LQSLTGAPRLL AIA D+I+P L+ F
Sbjct: 487 GDGVSRNLVVGTLAWPSPWVIVVGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFG 546
Query: 336 VADGS-EPHVATLFTAFLCSGCVVIGNLDLITPTVTMFFLLCYAGVNLSCFLLDLLDAPS 394
+ EP A L TA + ++I +LD++ P ++MFFL+CY VNL+C + LL P+
Sbjct: 547 HGKANGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPN 606
Query: 395 WRPRWKFHHWSLSLVGALLC 414
WRPR+K++HW+LS +G LC
Sbjct: 607 WRPRFKYYHWALSFLGMSLC 626
Score = 134 bits (337), Expect = 5e-30
Identities = 72/180 (40%), Positives = 108/180 (60%), Gaps = 9/180 (5%)
Query: 11 IVGMGGIGGTLLLVALCGTCTFLTAISLSAIATNGAMKGGGPYYLIGRALGPEVGVSIGL 70
+VG G+ LL+V +C CT LTAIS+SAIATNG + GG Y++I R+LGPE G ++GL
Sbjct: 144 MVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGL 203
Query: 71 CFFLGNAVAGALYVLGAVETFLKAV-PAAGIFRETITQVNGTTIAQPIESPSSHDLQIYG 129
CF+LG A A+Y+LGA+E L + P A IF + T + S + +++++YG
Sbjct: 204 CFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGT--------HDMSSATLNNMRVYG 255
Query: 130 IVVTIVLCFIVFGGVKMINRVAPAFLIPVLFSLICIYLGILLAREDHPAEGITGLSLETL 189
+ + +VF GVK +N+ A FL V+ S++ IY+G + + D P + L TL
Sbjct: 256 TIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYVGGIKSAFDPPVFPVCMLGNRTL 315
Database: nr
Posted date: Jul 5, 2005 12:34 AM
Number of letters in database: 863,360,394
Number of sequences in database: 2,540,612
Lambda K H
0.326 0.142 0.439
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 697,919,097
Number of Sequences: 2540612
Number of extensions: 30041911
Number of successful extensions: 103201
Number of sequences better than 10.0: 753
Number of HSP's better than 10.0 without gapping: 276
Number of HSP's successfully gapped in prelim test: 477
Number of HSP's that attempted gapping in prelim test: 101826
Number of HSP's gapped (non-prelim): 1140
length of query: 414
length of database: 863,360,394
effective HSP length: 130
effective length of query: 284
effective length of database: 533,080,834
effective search space: 151394956856
effective search space used: 151394956856
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 76 (33.9 bits)
Lotus: description of TM0140.12