hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mbg/mbg05755/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA4255  ( 1460 res)   mbg05755

Scores for sequence family classification (score includes all domains):
Model       Description                                 Score    E-value  N 
--------    -----------                                 -----    ------- ---
Ion_trans   Ion transport protein                       433.3   2.1e-126   2
PKD_channel Polycystin cation channel                  -146.1      0.075   1

Parsed for domains:
Model       Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
--------    ------- ----- -----    ----- -----      -----  -------
Ion_trans     1/2     439   666 ..     1   228 []   234.7  1.3e-66
Ion_trans     2/2     754   965 ..     1   228 []   207.1  2.8e-58
PKD_channel   1/1     603   972 ..     1   458 []  -146.1    0.075

Alignments of top-scoring domains:
Ion_trans: domain 1 of 2, from 439 to 666: score 234.7, E = 1.3e-66
                   *->ileildyvftviFtlEmllkiialgfklhsriafkYlrspwNilDfl
                      +l + +y+ft+iF++Em +k++alg+  +    ++Yl+s wN+lD l
   mKIAA4255   439    FLSVSNYIFTAIFVVEMMVKVVALGLLWG---EHAYLQSSWNVLDGL 482  

                   vvlpslislilsllgggsegdlyvreskfsttpegsygllsvlrllRllR
                    vl+sl+++i+     g                  +  +l+vlr+lRllR
   mKIAA4255   483 LVLVSLVDIIVAVASAG------------------GAKILGVLRVLRLLR 514  

                   vLRllrlirrapglfRWelrtlGWelnslgrslksllnvllllllllfif
                   +LR+lr+i+rapg     l+ +   + +l+ sl++++n++l+++ +++if
   mKIAA4255   515 TLRPLRVISRAPG-----LKLV---VETLISSLRPIGNIVLICCAFFIIF 556  

                   aiigvqlFggelnkcc..................npingntnFdsfgnal
                   +i+gvqlF+g++++c+++++ + +++ +++  + +++ ++ nFd+ g+al
   mKIAA4255   557 GILGVQLFKGKFYYCEgtdtrnittkaechaahyRWVRRKYNFDNLGQAL 606  

                   lwlFqtmTteGwgdvmpdtl...........agtvlgkiyfvsfiilggf
                   ++lF++++ +Gw+++m+d+l+  + ++++ +++++++ +yf+sf ++++f
   mKIAA4255   607 MSLFVLSSKDGWVNIMYDGLdavgidqqpvqNHNPWMLLYFISFLLIVSF 656  

                   lllNLfiavi<-*
                   ++lN+f++v+   
   mKIAA4255   657 FVLNMFVGVV    666  

Ion_trans: domain 2 of 2, from 754 to 965: score 207.1, E = 2.8e-58
                   *->ileildyvftviFtlEmllkiialgfklhsriafkYlrspwNilDfl
                      +l++++yvft++F++E+ lk++a+gf       +++++++wN lD++
   mKIAA4255   754    ALKYCNYVFTIVFVFEAALKLVAFGF-------RRFFKDRWNQLDLA 793  

                   vvlpslislilsllgggsegdlyvreskfsttpe.gsygllsvlrllRll
                   +vl+s+++++l++ +++              +  ++++++++++r+lR+ 
   mKIAA4255   794 IVLLSIMGIALEEIEMN--------------AALpINPTIIRIMRVLRIA 829  

                   RvLRllrlirrapglfRWelrtlGWelnslgrslksllnvllllllllfi
                   R   +l+l+++a g     +r l   l +++++l++ +n++ll++ll+fi
   mKIAA4255   830 R---VLKLLKMATG-----MRAL---LDTVVQALPQVGNLGLLFMLLFFI 868  

                   faiigvqlFggelnkcc...npingntnFdsfgnallwlFqtmTteGwgd
                   +a +gv lFg  +  +++++++  ++  F++fg+a+l+lF+++T+++w++
   mKIAA4255   869 YAALGVELFGRLECSEDnpcEGLSRHATFTNFGMAFLTLFRVSTGDNWNG 918  

                   vmpdtl............agtvlgkiyfvsfiilggflllNLfiavi<-*
                   +m dtl++ ++++++  +   +l+ +yfv+f+++  f+l+N+++av+   
   mKIAA4255   919 IMKDTLrectredkhclsYLPALSPVYFVTFVLVAQFVLVNVVVAVL    965  

PKD_channel: domain 1 of 1, from 603 to 972: score -146.1, E = 0.075
                   *->spglltvtdlddiwdwlssvL..LpglywtktsnNqs.tsgnegfih
                       ++l +   l++   w+++  ++L+++        q  ++ n++++ 
   mKIAA4255   603    GQALMSLFVLSSKDGWVNIMYdgLDAVG----IDQQPvQNHNPWMLL 645  

                   yessllLGvpRLRQvRvrnssctvppdfrdeinevaEIHChavyspgseD
                   y  s lL           +        f ++ n       +++  ++ + 
   mKIAA4255   646 YFISFLL---------IVS--------F-FVLNM------FVGVVVENFH 671  

                   tkdYspsWslPykrmgyndkdwriYspwvPseyspeFLneLLlgawhwGv
                   +            r ++++ ++r  ++           + L  ++ +  +
   mKIAA4255   672 K-----------CRQHQEAEEARRREE-----------KRL-RRLERRRR 698  

                   lasYpsvgGYvvlLplsreeslkalaeLqdnnWLDrrTRAvFveFtlYNa
                    a  +    Y     +++  ++ ++ +L  ++ LD     +F+ F     
   mKIAA4255   699 KAQRRP---Y----YADYSHTRRSIHSLCTSHYLD-----LFITF----- 731  

                   ntNLFcvvtLlvEfPpsGgvlpsvsvqsvkLlryvtglslflllceiifl
                                       +  + v + ++  y+   sl + l   + +
   mKIAA4255   732 --------------------IICLNVITMSMEHYNQPKSLDEAL-KYCNY 760  

                   vfvlyFvveeitkirregIlsylrsvWnlLdlaivalsvvvivLhiyRdf
                   vf + Fv+e ++k+   g ++ +++ Wn+Ldlaiv+ls+  i L    ++
   mKIAA4255   761 VFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSIMGIALEEIEMN 810  

                   latqlwkqvlkaspvdFidFdrvarldqlyriilAfllFLtwlKlfkvLr
                    a  +   ++              r   ++ri+          +++k+L 
   mKIAA4255   811 AALPINPTII--------------RIMRVLRIA----------RVLKLLK 836  

                   FnrtmslftkTLsralkellgfavmfvIlflAYaqlgyLlfG........
                    +  m+ +  T   al+ +  ++++f +lf+ Ya+lg+ lfG+ + ++++
   mKIAA4255   837 MATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGrlecsedn 886  

                   .....sqvdnfsnfvksiltlVGtcyfrgilgdfqp.......teiesgn
                   + ++ s +++f nf  ++ltl     fr  +gd  ++  +++  e+  + 
   mKIAA4255   887 pceglSRHATFTNFGMAFLTL-----FRVSTGDNWNgimkdtlRECTRED 931  

                   rv.......LGpLlfltfvflvifiLLNlflaiIndsYnev<-*
                   ++  +  + L+p++f+tfv++  f+L N+ +a+++   +e    
   mKIAA4255   932 KHclsylpaLSPVYFVTFVLVAQFVLVNVVVAVLMKHLEES    972  

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