hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file: /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file: /cdna4/rodent/full/goal/mfj/mfj21276/w3open/interpro/cnk_1/seq.in
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Query: mKIAA4228 ( 1123 res) mfj21276
Scores for sequence family classification (score includes all domains):
Model Description Score E-value N
-------- ----------- ----- ------- ---
Homeobox Homeobox domain 160.2 3.6e-44 2
zf-C2H2 Zinc finger, C2H2 type 23.3 0.0059 4
SSDP Single-stranded DNA binding protein, S -98.2 0.23 1
Cytadhesin_P30 Cytadhesin P30/P32 -154.9 0.69 1
TolA TolA protein -157.2 0.71 1
Parsed for domains:
Model Domain seq-f seq-t hmm-f hmm-t score E-value
-------- ------- ----- ----- ----- ----- ----- -------
Homeobox 1/2 48 104 .. 1 57 [] 86.8 4.5e-22
zf-C2H2 1/4 117 140 .. 1 24 [] 14.6 2.4
Homeobox 2/2 352 408 .. 1 57 [] 76.6 5.1e-19
zf-C2H2 2/4 429 453 .. 1 24 [] 7.2 20
Cytadhesin_P30 1/1 358 616 .. 1 312 [] -154.9 0.69
zf-C2H2 3/4 889 912 .. 1 24 [] 10.0 11
zf-C2H2 4/4 949 973 .. 1 24 [] 3.8 42
TolA 1/1 693 1030 .. 1 448 [] -157.2 0.71
SSDP 1/1 755 1057 .. 1 487 [] -98.2 0.23
Alignments of top-scoring domains:
Homeobox: domain 1 of 2, from 48 to 104: score 86.8, E = 4.5e-22
*->rrkRTtftpeQleeLEkeFqknrYPsreeReeLAkkLgLterqVkvW
+r RTt+tpeQle+L +++ +++P+r++ ++A++ gL +r+V+vW
mKIAA4228 48 KRLRTTITPEQLEILYQKYLLDSNPTRKMLDHIAHEVGLKKRVVQVW 94
FQNRRaKwKk<-*
FQN Ra+++k
mKIAA4228 95 FQNTRARERK 104
zf-C2H2: domain 1 of 4, from 117 to 140: score 14.6, E = 2.4
*->ykCpfdCgksFsrksnLkrHlrt.H<-*
+Cp C F+ k L++H+r++H
mKIAA4228 117 RRCP-FCRALFKAKTALEAHIRSrH 140
Homeobox: domain 2 of 2, from 352 to 408: score 76.6, E = 5.1e-19
*->rrkRTtftpeQleeLEkeFqknrYPsreeReeLAkkLgLterqVkvW
+r RT t+ Ql++L+ +F+ r+P+ e e L + +gL++r+V+vW
mKIAA4228 352 KRFRTQMTNLQLKVLKSCFNDYRTPTMLECEVLGNDIGLPKRVVQVW 398
FQNRRaKwKk<-*
FQN RaK+Kk
mKIAA4228 399 FQNARAKEKK 408
zf-C2H2: domain 2 of 4, from 429 to 453: score 7.2, E = 20
*->ykCpfdCgksFsrksnLkrHlrt..H<-*
+C+ Cg ++s + + + H+ +++H
mKIAA4228 429 TECT-LCGIKYSARLSVRDHIFSqqH 453
Cytadhesin_P30: domain 1 of 1, from 358 to 616: score -154.9, E = 0.69
*->MkLfslkklKklL....valsL...vfssvLivsLsllalaLvqHnn
M lk lK+ +++ + +L+ +v+ + + + v n
mKIAA4228 358 MTNLQLKVLKSCFndyrTPTMLeceVLGNDIGL---PKRVVQVWFQN 401
tELsEvKselSpLtvVLHqaEdeTvsiqGrkIteqpWFiPtVAg...sfG
E Ks lS H T +++ te t g + s+
mKIAA4228 402 ARAKEKKSKLSM---AKHFGINQTSYEGPK--TEC-----TLCGikySAR 441
fsalAiiLGLAIGLPIvKrKEk...rLLeEkErqe.qlaEqLqrIseQqe
+s+ i I K K ++ L EkE ++ + qL +Qqe
mKIAA4228 442 LSVRDHIFSQQH---ISKVKDTigsQLDKEKEYFDpATVRQL---MAQQE 485
eqavEPleeqnaqeataeAeVevAnqPqmgirqPqirpqFgPNpQQRtGf
+ + e+ +a ++ + A P + P p+ +
mKIAA4228 486 LDRIKKANEVLGLAAQQQGMFDNA--PLQALNLPTTYPALQG-------I 526
npPnQcFGGPmQPNqmamrPGFNqMpPnmQrgGmnPnqMaqRPGFPnQmP
+p + PG + P PGF P
mKIAA4228 527 PP--------------VLLPG---LNS--------PS----LPGF---TP 544
PqmagrPprpnfPnmaPNMnqPRPGFnrPqPggavrpgnKAGGGFnHPg.
+ a p+pn + P P PG P g +p A + P +
mKIAA4228 545 ANTALTSPKPNLMGL-PSTTVPSPGL--PTSGLPNKPSS-ASLSSPTPAq 590
tPMaprpgffPnqgmaprPsmagPraGlpP<-*
Ma p +P++++ ++P +++P pP
mKIAA4228 591 ATMAMAPQPPPQPQQPQPPVQQPP----PP 616
zf-C2H2: domain 3 of 4, from 889 to 912: score 10.0, E = 11
*->ykCpfdCgksFsrksnLkrHlrt.H<-*
+C +C+ F + + ++Hl++ +
mKIAA4228 889 LVCR-KCQAGFGDEEAARSHLKSlC 912
zf-C2H2: domain 4 of 4, from 949 to 973: score 3.8, E = 42
*->ykCpfdCgksFsrksnLkrHlrt..H<-*
y C C + + + L +Hl + H
mKIAA4228 949 YHCL-ACESALCGEEALSQHLESalH 973
TolA: domain 1 of 1, from 693 to 1030: score -157.2, E = 0.71
*->keqndklkrAiiISvvLHiiL...........ialLilgSldetvep
++ + A+ S L +++ ++ ++ ++L g l + +
mKIAA4228 693 QAALTSDPTALLTSQFLPYFVpgfspyyapqiPGALQSGYLQPMYGM 739
epgGeGggsvidAVm.VDpgaVaqQynrlqqQkedaarkekktEPvvEEk
e+ + +A m+ pg qQy++ qq ++a +++
mKIAA4228 740 EGLFPYSPALSQALMgLSPGSLLQQYQQYQQSLQEAIQQQ---------- 779
PvePdqeRkkklqrqaeeleqkraaEqerlKeLekerlqaqeaakkqaEe
+++ +q++++ q+++++L+ +++q+q+ + q+++
mKIAA4228 780 ---------------QQQQQQQQQQQQQQQRQLQQQQQQQQQKVQ-QQQQ 813
arkqaeeqqKqaEEakakqakEaakaKaeAeaaKakeeaerkakeekaaA
+ +q + q + a k+ aK+ k e ++ + e
mKIAA4228 814 QQQQPKASQTPVPQGPASPDKDP--AKESP-----KPEEQKNVPRE--VS 854
aAakkAEeeakakaAAeAkkkAeaeaAelkkkakarEaaaAeAkkkaeaE
+ k ee +A+ + A+ l ++
mKIAA4228 855 PLLPKPPEEP---EAESKSASAD----SLCDPFIVPK------------- 884
AkaKaaaeAeaKAkaEkAkAdaeAkaKAeaerkAdeeAAkeKAAAEAakK
+ + K +a + EAa
mKIAA4228 885 ---VQYKLVCRKCQAG-------------------------FGDEEAARS 906
AaaekeraaaaeakrKAAAEkaAaadqeaevdDifGsLssgkNapkqGgg
+ + + L + +G+g
mKIAA4228 907 HLKSLCCF------------GQSVVN-----------LQEMVLHVPTGSG 933
AkGagaasadsGktkksGasGaevdqYagqiksaIqsrlldddsyaGKtC
+ + +++G+++ +G s + ++ ++ s l + + +t
mKIAA4228 934 G-----GGGGGGGSGGGGGSYHCLACESALCGEEALSQHLESALHKHRTI 978
rvrikLapDGtdallisvksegGDpalCqAAlaAvAktakiPkpPsddaV
+ + a l+ + Dp + +A A + P+pPs +
mKIAA4228 979 TRAARNAKEH--PSLLPHSACFPDPSTASTSQSA-AHSNDSPPPPSAA-- 1023
YeklKninldfkl<-*
+ +
mKIAA4228 1024 ------PSSSASP 1030
SSDP: domain 1 of 1, from 755 to 1057: score -98.2, E = 0.23
*->gseevsAYmSyIetlrkKaRlnLQeiQknslseakafhdYsaAaaPs
g + s LQ+ Q+ ++ ++
mKIAA4228 755 GLSPGSL---------------LQQYQQ----YQQSLQE-------- 774
pvlgamqqqidmsqlhigaGfFQPflsqRaqhlqrqPhnPnamlnpqsRe
a+qqq + +q q++q+q
mKIAA4228 775 ----AIQQQQQQQQQ---------------QQQQQQ-------------- 791
tFPPtAAqLQQlkqlHyrQlQsvQQQQkQqQQkktqQsqsqPpsqlpgsQ
QQ++ql +Q+Q++Q Q+QqQQ++++ +P q p s+
mKIAA4228 792 ---------QQQRQLQQQQQQQQQKVQQQQQQQQQPKASQTPVPQGPASP 832
PltPdtHqqqPtkQQqPirddrSilaspraqGhPgmngFrPmlRatPprG
d + P k ++ + + P + P l+ +P
mKIAA4228 833 ----D---KDPAKE---------SPKPEEQKNVPREVS--PLLPKPPEEP 864
meqs.....nPLYDttGLnGGqYPvvqnsAqPLLHeinFAsnRnPHLksk
+ s++ + + L D + qY v q + A HLks
mKIAA4228 865 EAESksasaDSLCDPFIVPKVQYKLVCRKCQAGFGDEEAARS---HLKSL 911
aavervklPtQrkSLDkPkPAqqPaagkrmGpqpqnyGgglrPppnslLY
+ Q L + G Ggg + s
mKIAA4228 912 CCFGQSVVNLQEMVLHV-----------PTGS-----GGGGGGGGGS--- 942
nFlksAAgpGlPAmnmLHstsGGMgPgRLnPALknYmeeLkLLeqqnkkR
g G + L s g
mKIAA4228 943 -------GGGGGSYHCLACESALCGEE----------------------- 962
LLLvsqekeRkGYtsAsPDRPLsqtitessvAktksttPkstDtPteAtt
Lsq + es+ k + t + +
mKIAA4228 963 --------------------ALSQHL-ESALHKHRTITRAARNAKEHPSL 991
sPvkvptpnpsttnsLpgsassnipGsyigPmLqnGLPllTPggggPfpG
P +p pst+ + a sn +P P+ + P
mKIAA4228 992 LPHSACFPDPSTASTSQSAAHSNDS----PP----------PPSAAP--- 1024
tlImpsPgsstnssdntlkvmnltgfsqtrSnfplgpnpkgpsqv<-*
s++s+ +s ++ +++ ++r++ p ++ p+ +
mKIAA4228 1025 ----SSSASPHAS-------RKSWPPVGSRASAAK-PPSFPPLSS 1057
//