hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data11/genetics/InterProScan/iprscan/data/Pfam Sequence file: /cdna4/rodent/full/goal/mpf/mpf00382/w3open/interpro/cnk_1/seq.in - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: mKIAA4226 ( 2225 res) mpf00382 Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- EGF_CA Calcium binding EGF domain 1211.1 0 37 EGF EGF-like domain 598.8 3.3e-176 37 TB TB domain 469.2 3.3e-137 7 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- TB 1/7 24 66 .. 1 45 [] 74.3 2.5e-18 EGF 1/37 83 119 .. 1 39 [] 29.5 7.7e-05 EGF_CA 1/37 79 119 .. 1 55 [] 51.9 1.4e-11 EGF 2/37 125 161 .. 1 39 [] 31.6 1.8e-05 EGF_CA 2/37 121 161 .. 1 55 [] 38.4 1.6e-07 EGF 3/37 167 201 .. 1 39 [] 32.0 1.4e-05 EGF_CA 3/37 163 201 .. 1 55 [] 31.6 1.8e-05 TB 2/7 216 259 .. 1 45 [] 56.8 4.7e-13 EGF 4/37 270 306 .. 1 39 [] 32.1 1.3e-05 EGF_CA 4/37 266 306 .. 1 55 [] 37.5 3e-07 TB 3/7 321 362 .. 1 45 [] 74.2 2.8e-18 EGF 5/37 388 424 .. 1 39 [] 21.4 0.021 EGF_CA 5/37 384 424 .. 1 55 [] 35.1 1.6e-06 EGF 6/37 430 467 .. 1 39 [] 11.5 1.4 EGF_CA 6/37 426 467 .. 1 55 [] 40.6 3.5e-08 EGF_CA 7/37 469 509 .. 1 55 [] 40.3 4.4e-08 EGF 7/37 473 509 .. 1 39 [] 25.2 0.0015 EGF_CA 8/37 511 551 .. 1 55 [] 45.2 1.4e-09 EGF 8/37 515 551 .. 1 39 [] 20.7 0.034 EGF_CA 9/37 553 592 .. 1 55 [] 40.1 5e-08 EGF 9/37 557 592 .. 1 39 [] 23.9 0.0037 EGF_CA 10/37 594 634 .. 1 55 [] 35.8 1e-06 EGF 10/37 598 634 .. 1 39 [] 24.0 0.0034 EGF 11/37 640 676 .. 1 39 [] 15.0 0.65 EGF_CA 11/37 636 676 .. 1 55 [] 36.1 8e-07 EGF 12/37 682 717 .. 1 39 [] 28.4 0.00016 EGF_CA 12/37 678 717 .. 1 55 [] 54.6 2.2e-12 EGF 13/37 723 758 .. 1 39 [] 32.1 1.3e-05 EGF_CA 13/37 719 758 .. 1 55 [] 61.1 2.3e-14 EGF 14/37 764 800 .. 1 39 [] 32.9 7.1e-06 EGF_CA 14/37 760 800 .. 1 55 [] 39.5 7.4e-08 EGF_CA 15/37 802 841 .. 1 55 [] 29.3 8.9e-05 EGF 15/37 806 841 .. 1 39 [] 21.1 0.026 EGF_CA 16/37 843 882 .. 1 55 [] 30.9 2.9e-05 EGF 16/37 847 882 .. 1 39 [] 19.1 0.11 TB 4/7 902 943 .. 1 45 [] 66.6 5.4e-16 EGF_CA 17/37 961 1001 .. 1 55 [] 39.2 9.1e-08 EGF 17/37 965 1001 .. 1 39 [] 32.2 1.2e-05 EGF_CA 18/37 1003 1043 .. 1 55 [] 20.9 0.0045 EGF 18/37 1007 1043 .. 1 39 [] 15.3 0.6 TB 5/7 1058 1101 .. 1 45 [] 86.4 5.6e-22 EGF_CA 19/37 1119 1159 .. 1 55 [] 50.0 5.3e-11 EGF 19/37 1123 1159 .. 1 39 [] 13.7 0.86 EGF 20/37 1165 1201 .. 1 39 [] 15.5 0.58 EGF_CA 20/37 1161 1201 .. 1 55 [] 49.1 9.6e-11 EGF 21/37 1207 1243 .. 1 39 [] 19.8 0.065 EGF_CA 21/37 1203 1243 .. 1 55 [] 30.9 2.9e-05 EGF 22/37 1249 1282 .. 1 39 [] 19.0 0.11 EGF_CA 22/37 1245 1282 .. 1 55 [] 41.3 2.2e-08 EGF_CA 23/37 1284 1325 .. 1 55 [] 51.5 1.9e-11 EGF 23/37 1288 1325 .. 1 39 [] 26.6 0.00057 EGF_CA 24/37 1327 1365 .. 1 55 [] 46.2 7.4e-10 EGF 24/37 1331 1365 .. 1 39 [] 20.1 0.054 EGF 25/37 1371 1407 .. 1 39 [] 39.4 8.1e-08 EGF_CA 25/37 1367 1407 .. 1 55 [] 38.3 1.7e-07 TB 6/7 1422 1465 .. 1 45 [] 77.5 2.8e-19 EGF 26/37 1486 1522 .. 1 39 [] 43.1 6.4e-09 EGF_CA 26/37 1482 1522 .. 1 55 [] 39.7 6.6e-08 EGF 27/37 1528 1562 .. 1 39 [] 24.4 0.0027 EGF_CA 27/37 1524 1562 .. 1 55 [] 35.5 1.2e-06 EGF 28/37 1568 1603 .. 1 39 [] 24.1 0.0033 EGF_CA 28/37 1564 1603 .. 1 55 [] 42.7 8.4e-09 EGF 29/37 1609 1647 .. 1 39 [] 22.3 0.011 EGF_CA 29/37 1605 1647 .. 1 55 [] 45.6 1.1e-09 EGF_CA 30/37 1649 1689 .. 1 55 [] 39.6 7e-08 EGF 30/37 1653 1689 .. 1 39 [] 24.0 0.0036 TB 7/7 1704 1747 .. 1 45 [] 81.8 1.4e-20 EGF 31/37 1764 1800 .. 1 39 [] 23.1 0.0066 EGF_CA 31/37 1760 1800 .. 1 55 [] 43.9 3.6e-09 EGF_CA 32/37 1802 1841 .. 1 55 [] 55.9 8.8e-13 EGF 32/37 1806 1841 .. 1 39 [] 33.7 4.2e-06 EGF_CA 33/37 1843 1880 .. 1 55 [] 54.1 3e-12 EGF 33/37 1847 1880 .. 1 39 [] 15.5 0.57 EGF_CA 34/37 1882 1923 .. 1 55 [] 36.9 4.6e-07 EGF 34/37 1886 1923 .. 1 39 [] 28.8 0.00013 EGF_CA 35/37 1925 1963 .. 1 55 [] 25.2 0.0015 EGF 35/37 1929 1963 .. 1 39 [] 20.0 0.057 EGF_CA 36/37 1965 2004 .. 1 55 [] 28.8 0.00013 EGF 36/37 1969 2004 .. 1 39 [] 7.5 3.5 EGF_CA 37/37 2006 2044 .. 1 55 [] 29.6 7.1e-05 EGF 37/37 2010 2044 .. 1 39 [] 20.6 0.037 Alignments of top-scoring domains: TB: domain 1 of 7, from 24 to 66: score 74.3, E = 2.5e-18 *->grCsnplpgravTKseCCCsvGrgeAWGtpCElCPvpgtaefkeL<- g+C +p+pg+ vTKseCCC+ + ++G+pC++CP++++aef++L mKIAA4226 24 GVCVRPFPGA-VTKSECCCANPDY-GFGEPCQPCPAKNSAEFHGL 66 * mKIAA4226 - - EGF: domain 1 of 37, from 83 to 119: score 29.5, E = 7.7e-05 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* C+ +++ C n G+C +++g+y+C C G y + +G++C mKIAA4226 83 CALDPDICAN-GICENLRGSYRCNCNSG-YEPDASGRNC 119 EGF_CA: domain 1 of 37, from 79 to 119: score 51.9, E = 1.4e-11 *->DvDECatgtlhvCpDpdentvCvNtiGSFeCvarkdCpeGYeVpvse D++ECa + ++C +n++C+N GS++C C +GYe mKIAA4226 79 DINECALDP-DIC----ANGICENLRGSYRCN----CNSGYE----- 111 nnedgtnC<-* + + g nC mKIAA4226 112 PDASGRNC 119 EGF: domain 2 of 37, from 125 to 161: score 31.6, E = 1.8e-05 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* C n C+n G C++tpg+y+C CppG y++ ++C mKIAA4226 125 CLVNRLLCDN-GLCRNTPGSYSCTCPPG-YVFRTETETC 161 EGF_CA: domain 2 of 37, from 121 to 161: score 38.4, E = 1.6e-07 *->DvDECatgtlhvCpDpdentvCvNtiGSFeCvarkdCpeGYeVpvse D+DEC + C+ n+ C Nt GS++C+ Cp+GY mKIAA4226 121 DIDECLVNR-LLCD----NGLCRNTPGSYSCT----CPPGYV----- 153 nnedgtnC<-* ++ ++C mKIAA4226 154 FRTETETC 161 EGF: domain 3 of 37, from 167 to 201: score 32.0, E = 1.4e-05 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* C +n pC n G C++ g+++CeC pG + l+ tG C mKIAA4226 167 CESN--PCVN-GACRNNLGSFHCECSPG-SKLSSTGLIC 201 EGF_CA: domain 3 of 37, from 163 to 201: score 31.6, E = 1.8e-05 *->DvDECatgtlhvCpDpdentvCvNtiGSFeCvarkdCpeGYeVpvse Dv+EC++ + C n+ C N+ GSF C+ C++G + mKIAA4226 163 DVNECES---NPC----VNGACRNNLGSFHCE----CSPGSK----- 193 nnedgtnC<-* g C mKIAA4226 194 LSSTGLIC 201 TB: domain 2 of 7, from 216 to 259: score 56.8, E = 4.7e-13 *->grCsnplpgravTKseCCCsvGrgeAWGtpCElCPvpgta..efkeL +rC+++++g+ + KseCC+++G+ AWG+pCE C ++ ++++f+++ mKIAA4226 216 NRCEVNINGA-TLKSECCATLGA--AWGSPCERCELDAACprGFARI 259 <-* mKIAA4226 - - EGF: domain 4 of 37, from 270 to 306: score 32.1, E = 1.3e-05 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* C +g C n G+Cv++ g+++CeCp+G + l++tG+ C mKIAA4226 270 CEVFPGVCPN-GRCVNSKGSFHCECPEG-LTLDGTGRVC 306 EGF_CA: domain 4 of 37, from 266 to 306: score 37.5, E = 3e-07 *->DvDECatgtlhvCpDpdentvCvNtiGSFeCvarkdCpeGYeVpvse Dv+EC+ ++ vCp n+ CvN +GSF C+ CpeG + mKIAA4226 266 DVNECEVFP-GVCP----NGRCVNSKGSFHCE----CPEGLT----- 298 nnedgtnC<-* + g +C mKIAA4226 299 LDGTGRVC 306 TB: domain 3 of 7, from 321 to 362: score 74.2, E = 2.8e-18 *->grCsnplpgravTKseCCCsvGrgeAWGtpCElCPvpgtaefkeL<- +C +p+pg+ +++++CCC+vG+ AWGt+CE+CP+pgt+e+++L mKIAA4226 321 DECIHPVPGK-FRMDACCCAVGA--AWGTECEECPKPGTKEYETL 362 * mKIAA4226 - - EGF: domain 5 of 37, from 388 to 424: score 21.4, E = 0.021 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* C +g C G+C++t g+++C+C G ++l+ ++C mKIAA4226 388 CKAFPGMCTY-GKCRNTIGSFKCRCNNG-FALDMEERNC 424 EGF_CA: domain 5 of 37, from 384 to 424: score 35.1, E = 1.6e-06 *->DvDECatgtlhvCpDpdentvCvNtiGSFeCvarkdCpeGYeVpvse D++EC ++ +C ++C NtiGSF+C+ C G+ mKIAA4226 384 DINECKAFP-GMC----TYGKCRNTIGSFKCR----CNNGFA----- 416 nnedgtnC<-* ++ nC mKIAA4226 417 LDMEERNC 424 EGF: domain 6 of 37, from 430 to 467: score 11.5, E = 1.4 *->CspnngpCsngGtCvdtpggytCeCppGdyfllyt.....GkrC<-* C ++ C G+Cv+tpg+++CeC +G y ++ +k+C mKIAA4226 430 CRISPDLCGS-GICVNTPGSFECECFEG-----YEsgfmmMKNC 467 EGF_CA: domain 6 of 37, from 426 to 467: score 40.6, E = 3.5e-08 *->DvDECatgtlhvCpDpdentvCvNtiGSFeCvarkdCpeGYeVpvse D+DEC++ + + C+ +++CvNt GSFeC+ C eGYe mKIAA4226 426 DIDECRISP-DLCG----SGICVNTPGSFECE----CFEGYE----S 459 nnedgtnC<-* +nC mKIAA4226 460 GFMMMKNC 467 EGF_CA: domain 7 of 37, from 469 to 509: score 40.3, E = 4.4e-08 *->DvDECatgtlhvCpDpdentvCvNtiGSFeCvarkdCpeGYeVpvse D+DEC+ + C ++++CvNt+GSF+C Cp G e mKIAA4226 469 DIDECERNP-LLC----RGGTCVNTEGSFQCD----CPLGHE----- 501 nnedgtnC<-* + ++ C mKIAA4226 502 LSPSREDC 509 EGF: domain 7 of 37, from 473 to 509: score 25.2, E = 0.0015 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* C n+ C + GtCv+t+g+++C+Cp G + l+ + ++C mKIAA4226 473 CERNPLLCRG-GTCVNTEGSFQCDCPLG-HELSPSREDC 509 EGF_CA: domain 8 of 37, from 511 to 551: score 45.2, E = 1.4e-09 *->DvDECatgtlhvCpDpdentvCvNtiGSFeCvarkdCpeGYeVpvse D++EC + C +n++CvN iG+++C+ C +GY+ mKIAA4226 511 DINECSLSD-NLC----RNGKCVNMIGTYQCS----CNPGYQ----- 543 nnedgtnC<-* + +d+ C mKIAA4226 544 ATPDRQGC 551 EGF: domain 8 of 37, from 515 to 551: score 20.7, E = 0.034 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* Cs ++ C n G+Cv+ g+y+C C pG y+ + C mKIAA4226 515 CSLSDNLCRN-GKCVNMIGTYQCSCNPG-YQATPDRQGC 551 EGF_CA: domain 9 of 37, from 553 to 592: score 40.1, E = 5e-08 *->DvDECatgtlhvCpDpdentvCvNtiGSFeCvarkdCpeGYeVpvse D+DEC + C +t+C+N +GS+eC+ C+eGY mKIAA4226 553 DIDECMIMN-GGC-----DTQCTNSEGSYECS----CSEGYA----- 584 nnedgtnC<-* +dg C mKIAA4226 585 LMPDGRSC 592 EGF: domain 9 of 37, from 557 to 592: score 23.9, E = 0.0037 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* C ng+C+ +C++++g+y+C C +G y+l +G+ C mKIAA4226 557 CMIMNGGCDT--QCTNSEGSYECSCSEG-YALMPDGRSC 592 EGF_CA: domain 10 of 37, from 594 to 634: score 35.8, E = 1e-06 *->DvDECatgtlhvCpDpdentvCvNtiGSFeCvarkdCpeGYeVpvse D+DEC++ + ++C+ +++C+N G ++C+ C +G+ mKIAA4226 594 DIDECENNP-DICD----GGQCTNIPGEYRCL----CYDGFM----- 626 nnedgtnC<-* + d ++C mKIAA4226 627 ASMDMKTC 634 EGF: domain 10 of 37, from 598 to 634: score 24.0, E = 0.0034 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* C n++ C++ G+C++ pg+y+C C G + + ++k+C mKIAA4226 598 CENNPDICDG-GQCTNIPGEYRCLCYDG-FMASMDMKTC 634 EGF: domain 11 of 37, from 640 to 676: score 15.0, E = 0.65 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* C+ n++ C+ G+C +t g++ C+C+ G y + C mKIAA4226 640 CDLNPNICMF-GECENTKGSFICHCQLG-YSVKKGTTGC 676 EGF_CA: domain 11 of 37, from 636 to 676: score 36.1, E = 8e-07 *->DvDECatgtlhvCpDpdentvCvNtiGSFeCvarkdCpeGYeVpvse Dv+EC+ + ++C ++C+Nt+GSF C C GY+ mKIAA4226 636 DVNECDLNP-NIC----MFGECENTKGSFICH----CQLGYS----- 668 nnedgtnC<-* ++++ t C mKIAA4226 669 VKKGTTGC 676 EGF: domain 12 of 37, from 682 to 717: score 28.4, E = 0.00016 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* C ++C+ ++ C+++pg+++C C +G ++G++C mKIAA4226 682 CEIGAHNCDMHASCLNVPGSFKCSCREG---WVGNGIKC 717 EGF_CA: domain 12 of 37, from 678 to 717: score 54.6, E = 2.2e-12 *->DvDECatgtlhvCpDpdentvCvNtiGSFeCvarkdCpeGYeVpvse DvDEC++g+ h+C d ++C+N GSF+C+ C+eG+ mKIAA4226 678 DVDECEIGA-HNC---DMHASCLNVPGSFKCS----CREGWV----- 711 nnedgtnC<-* ++g +C mKIAA4226 712 --GNGIKC 717 EGF: domain 13 of 37, from 723 to 758: score 32.1, E = 1.3e-05 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* C+ ++ Cs +++Cv+tpg+y+C C +G + ++G +C mKIAA4226 723 CANGTHQCSINAQCVNTPGSYRCACSEG---FTGDGFTC 758 EGF_CA: domain 13 of 37, from 719 to 758: score 61.1, E = 2.3e-14 *->DvDECatgtlhvCpDpdentvCvNtiGSFeCvarkdCpeGYeVpvse D+DECa+gt h C + n++CvNt GS++C C+eG++ mKIAA4226 719 DLDECANGT-HQC---SINAQCVNTPGSYRCA----CSEGFT----- 752 nnedgtnC<-* +dg++C mKIAA4226 753 --GDGFTC 758 EGF: domain 14 of 37, from 764 to 800: score 32.9, E = 7.1e-06 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* C++n++ C n G+C+++pg y+CeC +G + + + + C mKIAA4226 764 CAENTNLCEN-GQCLNVPGAYRCECEMG-FTPASDSRSC 800 EGF_CA: domain 14 of 37, from 760 to 800: score 39.5, E = 7.4e-08 *->DvDECatgtlhvCpDpdentvCvNtiGSFeCvarkdCpeGYeVpvse DvDECa+ t + C en++C+N G ++C+ C+ G++ mKIAA4226 760 DVDECAENT-NLC----ENGQCLNVPGAYRCE----CEMGFT----- 792 nnedgtnC<-* + d+ C mKIAA4226 793 PASDSRSC 800 EGF_CA: domain 15 of 37, from 802 to 841: score 29.3, E = 8.9e-05 *->DvDECatgtlhvCpDpdentvCvNtiGSFeCvarkdCpeGYeVpvse D+DEC + + ++C ++C+N G F C+ C++GYe mKIAA4226 802 DIDECSF-Q-NIC----VFGTCNNLPGMFHCI----CDDGYE----- 833 nnedgtnC<-* g+nC mKIAA4226 834 LDRTGGNC 841 EGF: domain 15 of 37, from 806 to 841: score 21.1, E = 0.026 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* Cs +n C GtC+++pg+++C+C+ G y l+ tG +C mKIAA4226 806 CSFQN-ICVF-GTCNNLPGMFHCICDDG-YELDRTGGNC 841 EGF_CA: domain 16 of 37, from 843 to 882: score 30.9, E = 2.9e-05 *->DvDECatgtlhvCpDpdentvCvNtiGSFeCvarkdCpeGYeVpvse D+DECa++ +C n+ CvNt G +eC Cp+ ++ mKIAA4226 843 DIDECADPI--NC----VNGLCVNTPGRYECN----CPPDFQ----- 874 nnedgtnC<-* n+ g C mKIAA4226 875 LNPTGVGC 882 EGF: domain 16 of 37, from 847 to 882: score 19.1, E = 0.11 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* C++ +C n G Cv+tpg y+C Cpp ++l+ tG C mKIAA4226 847 CADPI-NCVN-GLCVNTPGRYECNCPPD-FQLNPTGVGC 882 TB: domain 4 of 7, from 902 to 943: score 66.6, E = 5.4e-16 *->grCsnplpgravTKseCCCsvGrgeAWGtpCElCPvpgtaefkeL<- C+ +++++ v++s+CCCs+G+ AWG+pCE CP++++ e+++L mKIAA4226 902 LSCNTEVGVG-VSRSSCCCSLGK--AWGNPCETCPPVNSTEYYTL 943 * mKIAA4226 - - EGF_CA: domain 17 of 37, from 961 to 1001: score 39.2, E = 9.1e-08 *->DvDECatgtlhvCpDpdentvCvNtiGSFeCvarkdCpeGYeVpvse D+DEC + + C +++ C+Nt GSF+C+ Cp+GY mKIAA4226 961 DIDECQELP-GLC----QGGNCINTFGSFQCE----CPQGYY----- 993 nnedgtnC<-* e+ C mKIAA4226 994 LSEETRIC 1001 EGF: domain 17 of 37, from 965 to 1001: score 32.2, E = 1.2e-05 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* C++ +g C++ G C++t g+++CeCp+G y+l+ + C mKIAA4226 965 CQELPGLCQG-GNCINTFGSFQCECPQG-YYLSEETRIC 1001 EGF_CA: domain 18 of 37, from 1003 to 1043: score 20.9, E = 0.0045 *->DvDECatgtlhvCpDpdentvCvNtiGSFeCvarkdCpeGYeVpvse D+DEC + vC+ ++C Nt G + C+ Cp+ Y mKIAA4226 1003 DIDECFAHP-GVCG----PGTCYNTLGNYTCI----CPPEYM----- 1035 nnedgtnC<-* +g+nC mKIAA4226 1036 QVNGGHNC 1043 EGF: domain 18 of 37, from 1007 to 1043: score 15.3, E = 0.6 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* C ++g C GtC +t g+ytC+Cpp y G++C mKIAA4226 1007 CFAHPGVCGP-GTCYNTLGNYTCICPPE-YMQVNGGHNC 1043 TB: domain 5 of 7, from 1058 to 1101: score 86.4, E = 5.6e-22 *->grCsnplpgravTKseCCCsvGrgeAWGtpCElCPvpgtaefkeL<- ++C+n+lp++ vTK++CCC+++ g+AW++pCE+CP+pgta+fk++ mKIAA4226 1058 TTCENELPFN-VTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTI 1101 * mKIAA4226 - - EGF_CA: domain 19 of 37, from 1119 to 1159: score 50.0, E = 5.3e-11 *->DvDECatgtlhvCpDpdentvCvNtiGSFeCvarkdCpeGYeVpvse D+DEC + + +C +n+vC+N iGSF+C+ Cp G++ mKIAA4226 1119 DIDECKEIP-GIC----ANGVCINQIGSFRCE----CPTGFS----- 1151 nnedgtnC<-* n+ +C mKIAA4226 1152 YNDLLLVC 1159 EGF: domain 19 of 37, from 1123 to 1159: score 13.7, E = 0.86 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* C + +g C n G C++ g+++CeCp G + ++ C mKIAA4226 1123 CKEIPGICAN-GVCINQIGSFRCECPTG-FSYNDLLLVC 1159 EGF: domain 20 of 37, from 1165 to 1201: score 15.5, E = 0.58 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* Cs ++ C+ ++ C+++pg+y+CeC+ G f l C mKIAA4226 1165 CSNGDNLCQRNADCINSPGSYRCECAAG--FKLSPNGAC 1201 EGF_CA: domain 20 of 37, from 1161 to 1201: score 49.1, E = 9.6e-11 *->DvDECatgtlhvCpDpdentvCvNtiGSFeCvarkdCpeGYeVpvse D+DEC +g + C ++n++C+N GS++C+ C +G++ mKIAA4226 1161 DIDECSNGD-NLC---QRNADCINSPGSYRCE----CAAGFK----- 1194 nnedgtnC<-* ++++C mKIAA4226 1195 -LSPNGAC 1201 EGF: domain 21 of 37, from 1207 to 1243: score 19.8, E = 0.065 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* C + ++ Cs+ G Cvd++g+y+C+C G + + ++ C mKIAA4226 1207 CLEIPNVCSH-GLCVDLQGSYQCICNNG-FKASQDQTMC 1243 EGF_CA: domain 21 of 37, from 1203 to 1243: score 30.9, E = 2.9e-05 *->DvDECatgtlhvCpDpdentvCvNtiGSFeCvarkdCpeGYeVpvse D +EC + + +vC + Cv +GS++C+ C G++ mKIAA4226 1203 DRNECLEIP-NVC----SHGLCVDLQGSYQCI----CNNGFK----- 1235 nnedgtnC<-* + d t C mKIAA4226 1236 ASQDQTMC 1243 EGF: domain 22 of 37, from 1249 to 1282: score 19.0, E = 0.11 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* C + pC n GtC +t g+y C C pG f l + +C mKIAA4226 1249 CERH--PCGN-GTCKNTVGSYNCLCYPG--FELTHNNDC 1282 EGF_CA: domain 22 of 37, from 1245 to 1282: score 41.3, E = 2.2e-08 *->DvDECatgtlhvCpDpdentvCvNtiGSFeCvarkdCpeGYeVpvse DvDEC+ h C+ n++C Nt+GS++C+ C +G+e mKIAA4226 1245 DVDECER---HPCG----NGTCKNTVGSYNCL----CYPGFE----- 1275 nnedgtnC<-* + ++ C mKIAA4226 1276 -LTHNNDC 1282 EGF_CA: domain 23 of 37, from 1284 to 1325: score 51.5, E = 1.9e-11 *->DvDECat.gtlhvCpDpdentvCvNtiGSFeCvarkdCpeGYeVpvs D+DEC + ++ vC +n+ C+N+iGSF+C+ C eGYe mKIAA4226 1284 DIDECSSfFG-QVC----RNGRCFNEIGSFKCL----CNEGYE---- 1317 ennedgtnC<-* +dg+nC mKIAA4226 1318 -LTPDGKNC 1325 EGF: domain 23 of 37, from 1288 to 1325: score 26.6, E = 0.00057 *->Cspnn.gpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* Cs+ ++ C n G+C + g+++C C +G y l +Gk+C mKIAA4226 1288 CSSFFgQVCRN-GRCFNEIGSFKCLCNEG-YELTPDGKNC 1325 EGF_CA: domain 24 of 37, from 1327 to 1365: score 46.2, E = 7.4e-10 *->DvDECatgtlhvCpDpdentvCvNtiGSFeCvarkdCpeGYeVpvse D +EC + +C ++C+N +GSF+C+ Cp+GYe mKIAA4226 1327 DTNECVALP-GSC----SPGTCQNLEGSFRCI----CPPGYE----- 1359 nnedgtnC<-* ++nC mKIAA4226 1360 --VRSENC 1365 EGF: domain 24 of 37, from 1331 to 1365: score 20.1, E = 0.054 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* C +g Cs GtC++++g+++C+CppG ++ ++C mKIAA4226 1331 CVALPGSCSP-GTCQNLEGSFRCICPPG---YEVRSENC 1365 EGF: domain 25 of 37, from 1371 to 1407: score 39.4, E = 8.1e-08 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* C+++++ C+ G C++tpgg++C+CppG ++l+ +G+rC mKIAA4226 1371 CDEDPNICLF-GSCTNTPGGFQCICPPG-FVLSDNGRRC 1407 EGF_CA: domain 25 of 37, from 1367 to 1407: score 38.3, E = 1.7e-07 *->DvDECatgtlhvCpDpdentvCvNtiGSFeCvarkdCpeGYeVpvse D++EC++ + ++C ++C+Nt G+F+C+ Cp+G+ mKIAA4226 1367 DINECDEDP-NIC----LFGSCTNTPGGFQCI----CPPGFV----- 1399 nnedgtnC<-* ++g C mKIAA4226 1400 LSDNGRRC 1407 TB: domain 6 of 7, from 1422 to 1465: score 77.5, E = 2.8e-19 *->grCsnplpgravTKseCCCsvGrgeAWGtpCElCPvpgtaefkeL<- g+Cs+p++++ +TK++CCCs + ge+WG+pCElCP++++++f+ L mKIAA4226 1422 GKCSVPKAFN-TTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDL 1465 * mKIAA4226 - - EGF: domain 26 of 37, from 1486 to 1522: score 43.1, E = 6.4e-09 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* C + +g Csn G+C++t+g+++CeCp+G y l+ytG rC mKIAA4226 1486 CLESPGICSN-GQCINTDGSFRCECPMG-YNLDYTGVRC 1522 EGF_CA: domain 26 of 37, from 1482 to 1522: score 39.7, E = 6.6e-08 *->DvDECatgtlhvCpDpdentvCvNtiGSFeCvarkdCpeGYeVpvse Dv+EC + + +C n++C+Nt+GSF+C+ Cp GY mKIAA4226 1482 DVNECLESP-GIC----SNGQCINTDGSFRCE----CPMGYN----- 1514 nnedgtnC<-* g C mKIAA4226 1515 LDYTGVRC 1522 EGF: domain 27 of 37, from 1528 to 1562: score 24.4, E = 0.0027 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* Cs n pC n GtC+++ g+++C C +G f + + +C mKIAA4226 1528 CSIGN-PCGN-GTCTNVIGSFECTCNEG--FEPGPMMNC 1562 EGF_CA: domain 27 of 37, from 1524 to 1562: score 35.5, E = 1.2e-06 *->DvDECatgtlhvCpDpdentvCvNtiGSFeCvarkdCpeGYeVpvse D DEC +g C+ n++C+N iGSFeC+ C eG+e mKIAA4226 1524 DTDECSIGN--PCG----NGTCTNVIGSFECT----CNEGFE----- 1555 nnedgtnC<-* ++ nC mKIAA4226 1556 -PGPMMNC 1562 EGF: domain 28 of 37, from 1568 to 1603: score 24.1, E = 0.0033 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* C++n+ C +C++t g+y+C Cp+G y+l ++k C mKIAA4226 1568 CAQNPLLCAF--RCMNTFGSYECTCPVG-YALREDQKMC 1603 EGF_CA: domain 28 of 37, from 1564 to 1603: score 42.7, E = 8.4e-09 *->DvDECatgtlhvCpDpdentvCvNtiGSFeCvarkdCpeGYeVpvse D++ECa+ + C ++ C Nt GS+eC+ Cp GY mKIAA4226 1564 DINECAQNP-LLC-----AFRCMNTFGSYECT----CPVGYA----- 1595 nnedgtnC<-* ed + C mKIAA4226 1596 LREDQKMC 1603 EGF: domain 29 of 37, from 1609 to 1647: score 22.3, E = 0.011 *->CspnngpCsng.GtCvdtpggytCeCppGdyfllytGkrC<-* C++ + C ++ C ++ g+++C+CppG ++ +G+ C mKIAA4226 1609 CAEGLHDCESRgMMCKNLIGTFMCICPPG-MARRPDGEGC 1647 EGF_CA: domain 29 of 37, from 1605 to 1647: score 45.6, E = 1.1e-09 *->DvDECatgtlhvCpDpdentvCvNtiGSFeCvarkdCpeGYeVpvse D+DECa+g h+C ++++ C N iG+F C+ Cp+G + mKIAA4226 1605 DLDECAEGL-HDCE--SRGMMCKNLIGTFMCI----CPPG-----MA 1639 nnedgtnC<-* +dg+ C mKIAA4226 1640 RRPDGEGC 1647 EGF_CA: domain 30 of 37, from 1649 to 1689: score 39.6, E = 7e-08 *->DvDECatgtlhvCpDpdentvCvNtiGSFeCvarkdCpeGYeVpvse D +EC+t + +C en+ CvN iGS++C+ C eG++ mKIAA4226 1649 DENECRTKP-GIC----ENGRCVNIIGSYRCE----CNEGFQ----- 1681 nnedgtnC<-* gt+C mKIAA4226 1682 SSSSGTEC 1689 EGF: domain 30 of 37, from 1653 to 1689: score 24.0, E = 0.0036 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* C +g C n G+Cv+ g+y+CeC +G ++ + +G C mKIAA4226 1653 CRTKPGICEN-GRCVNIIGSYRCECNEG-FQSSSSGTEC 1689 TB: domain 7 of 7, from 1704 to 1747: score 81.8, E = 1.4e-20 *->grCsnplpgr.avTKseCCCsvGrgeAWGtpCElCPvpgtaefkeL< ++C+++++ r+ vTKseCCC++Gr +WG++CElCP+pgta++k++ mKIAA4226 1704 TMCQMASSSRnLVTKSECCCDGGR--GWGHQCELCPLPGTAQYKKI 1747 -* mKIAA4226 - - EGF: domain 31 of 37, from 1764 to 1800: score 23.1, E = 0.0066 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* C ++ C n G+Cv+t g+++C+C++G y + +G C mKIAA4226 1764 CKVMPSLCTN-GQCVNTMGSFRCFCKVG-YTTDISGTAC 1800 EGF_CA: domain 31 of 37, from 1760 to 1800: score 43.9, E = 3.6e-09 *->DvDECatgtlhvCpDpdentvCvNtiGSFeCvarkdCpeGYeVpvse D+DEC + C n++CvNt GSF+C C+ GY+ mKIAA4226 1760 DIDECKVMP-SLC----TNGQCVNTMGSFRCF----CKVGYT----- 1792 nnedgtnC<-* + gt+C mKIAA4226 1793 TDISGTAC 1800 EGF_CA: domain 32 of 37, from 1802 to 1841: score 55.9, E = 8.8e-13 *->DvDECatgtlhvCpDpdentvCvNtiGSFeCvarkdCpeGYeVpvse D+DEC + + + C n++C Nt+GS++C+ Cp+GY mKIAA4226 1802 DLDECSQSP-KPC-----NFICKNTEGSYQCS----CPRGYV----- 1833 nnedgtnC<-* +edg++C mKIAA4226 1834 LQEDGKTC 1841 EGF: domain 32 of 37, from 1806 to 1841: score 33.7, E = 4.2e-06 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* Cs+ + pC+ +C +t+g+y+C Cp G y+l+ +Gk+C mKIAA4226 1806 CSQSPKPCNF--ICKNTEGSYQCSCPRG-YVLQEDGKTC 1841 EGF_CA: domain 33 of 37, from 1843 to 1880: score 54.1, E = 3e-12 *->DvDECatgtlhvCpDpdentvCvNtiGSFeCvarkdCpeGYeVpvse D+DEC t + h+C + CvNt G+F C Cp+G++ mKIAA4226 1843 DLDECQTKQ-HNC-----QFLCVNTLGGFTCK----CPPGFT----- 1874 nnedgtnC<-* t+C mKIAA4226 1875 --QHHTAC 1880 EGF: domain 33 of 37, from 1847 to 1880: score 15.5, E = 0.57 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkr..C<-* C+ ++C+ Cv+t gg+tC+CppG +t++++ C mKIAA4226 1847 CQTKQHNCQF--LCVNTLGGFTCKCPPG-----FTQHHtaC 1880 EGF_CA: domain 34 of 37, from 1882 to 1923: score 36.9, E = 4.6e-07 *->DvDECatgtlhvCpDpdentvCvNtiGSFeCvarkdCpeGYeVpvse D +EC + + C ++++C+Nt GSF+C+ C +G++ mKIAA4226 1882 DNNECGSQP-SLC---GAKGICQNTPGSFSCE----CQRGFS----- 1915 nnedgtnC<-* + g nC mKIAA4226 1916 LDASGLNC 1923 EGF: domain 34 of 37, from 1886 to 1923: score 28.8, E = 0.00013 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* C ++++ C G+C++tpg+++CeC+ G + l+ +G +C mKIAA4226 1886 CGSQPSLCGAKGICQNTPGSFSCECQRG-FSLDASGLNC 1923 EGF_CA: domain 35 of 37, from 1925 to 1963: score 25.2, E = 0.0015 *->DvDECatgtlhvCpDpdentvCvNtiGSFeCvarkdCpeGYeVpvse DvDEC++ h C C+N G+++C Cp+GY mKIAA4226 1925 DVDECDG-N-HRC-----QHGCQNILGGYRCG----CPQGYV----- 1955 nnedgtnC<-* ++C mKIAA4226 1956 QHYQWNQC 1963 EGF: domain 35 of 37, from 1929 to 1963: score 20.0, E = 0.057 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* C+ n+ C++ C++ ggy+C Cp+G y+ +y+ +C mKIAA4226 1929 CDGNH-RCQH--GCQNILGGYRCGCPQG-YVQHYQWNQC 1963 EGF_CA: domain 36 of 37, from 1965 to 2004: score 28.8, E = 0.00013 *->DvDECatgtlhvCpDpdentvCvNtiGSFeCvarkdCpeGYeVpvse D +EC +++ C+ +++C Nt GS++C Cp+G++ mKIAA4226 1965 DENECSNPG--ACG----SASCYNTLGSYKCA----CPSGFS----- 1996 nnedgtnC<-* + +C mKIAA4226 1997 FDQFSSAC 2004 EGF: domain 36 of 37, from 1969 to 2004: score 7.5, E = 3.5 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* Cs C + C +t g+y+C Cp G + ++ C mKIAA4226 1969 CSNPG-ACGS-ASCYNTLGSYKCACPSG-FSFDQFSSAC 2004 EGF_CA: domain 37 of 37, from 2006 to 2044: score 29.6, E = 7.1e-05 *->DvDECatgtlhvCpDpdentvCvNtiGSFeCvarkdCpeGYeVpvse Dv+EC + + + C + C Nt+G++ C Cp+GY mKIAA4226 2006 DVNECSSSK-NPC-----SYGCSNTEGGYLCG----CPPGYF----- 2037 nnedgtnC<-* + ++C mKIAA4226 2038 -RVGQGHC 2044 EGF: domain 37 of 37, from 2010 to 2044: score 20.6, E = 0.037 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* Cs+ ++pCs C +t+ggy C CppG ++ + +C mKIAA4226 2010 CSSSKNPCSY--GCSNTEGGYLCGCPPG--YFRVGQGHC 2044 //