hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/smart.HMMs
Sequence file:            /cdna4/rodent/full/goal/mbg/mbg07317/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA4223  ( 1076 res)   mbg07317

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
PDZ      Domain present in PSD-95, Dlg, and ZO-1/2.     468.5   3.3e-136   7

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
PDZ        1/7      78   152 ..     1    80 []    58.0  1.2e-12
PDZ        2/7     176   254 ..     1    80 []    87.5  1.5e-21
PDZ        3/7     277   352 ..     1    80 []    59.3  4.9e-13
PDZ        4/7     444   524 ..     1    80 []    71.0  1.5e-16
PDZ        5/7     545   621 ..     1    80 []    70.2  2.6e-16
PDZ        6/7     644   718 ..     1    80 []    76.1  4.2e-18
PDZ        7/7     962  1034 ..     1    80 []    58.8  6.8e-13

Alignments of top-scoring domains:
PDZ: domain 1 of 7, from 78 to 152: score 58.0, E = 1.2e-12
                   *->gglGfsivg......gifvssvvpGspAakaGrkslglLkvGDvIle
                        lG++++g+ ++++   vs++  G+ Aa++       L vGD I +
   mKIAA4223    78    TTLGLTVSGgidkdgKPRVSNLRQGGIAARSDQ-----LDVGDYIKA 119  

                   VNGetsvegltheeavdllkkaggggvGekvtLtvlRgg<-*
                   VNG +++  ++h+e++ llk+ g+     +v+L+v+++    
   mKIAA4223   120 VNG-INLAKFRHDEIISLLKNVGE-----RVVLEVEYEL    152  

PDZ: domain 2 of 7, from 176 to 254: score 87.5, E = 1.5e-21
                   *->gglGfsivg..........gifvssvvpGspAakaGrkslglLkvGD
                      + +Gf i+g+ +++++++++++++ v pG+pA++ G+     +k+GD
   mKIAA4223   176    NTFGFVIRGgahddrnksrPVVITCVRPGGPADREGT-----IKPGD 217  

                   vIleVNGetsvegltheeavdllkkaggggvGekvtLtvlRgg<-*
                   ++l+V+G + + g th+ea+ +lk++g+     + tL+++++    
   mKIAA4223   218 RLLSVDG-IRLLGTTHAEAMSILKQCGQ-----EATLLIEYDV    254  

PDZ: domain 3 of 7, from 277 to 352: score 59.3, E = 4.9e-13
                   *->gglGfsivg.......gifvssvvpGspAakaGrkslglLkvGDvIl
                      ++lG+ ++ +   +++ i++ +++  s A+++G      L+vGD+Il
   mKIAA4223   277    ASLGVALTTsvccnkqVIVIDKIKSASIADRCGA-----LHVGDHIL 318  

                   eVNGetsvegltheeavdllkkaggggvGekvtLtvlRgg<-*
                   +++G ts+e +t +ea ++l ++ +     +v+L++l+     
   mKIAA4223   319 SIDG-TSMEYCTLAEATQFLANTTD-----QVKLEILPHH    352  

PDZ: domain 4 of 7, from 444 to 524: score 71.0, E = 1.5e-16
                   *->gglGfsivg..........gifvssvvpGspAakaGrkslglLkvGD
                       g+G++++g+   +++ +++ ++s ++++spA+++G     +L++GD
   mKIAA4223   444    TGFGIQLQGsvfatetlssPPLISYIEADSPAERCG-----VLQIGD 485  

                   vIleVNGetsvegltheeavdllkkaggggvGekvtLtvlRgg<-*
                   +++++NG +++e+ t eea +ll+ ++  +   kvtL+++ +    
   mKIAA4223   486 RVMAING-IPTEDSTFEEANQLLRDSSITS---KVTLEIEFDV    524  

PDZ: domain 5 of 7, from 545 to 621: score 70.2, E = 2.6e-16
                   *->gglGfsivg........gifvssvvpGspAakaGrkslglLkvGDvI
                        lG++i++++++++++++++s++++Gs+A++ G+     L  GD++
   mKIAA4223   545    VELGITISSpssrkpgdPLVISDIKKGSVAHRTGT-----LELGDKL 586  

                   leVNGetsvegltheeavdllkkaggggvGekvtLtvlRgg<-*
                   l++++ + +++++ e+av++l+++ +      v+L++++++   
   mKIAA4223   587 LAIDN-IRLDNCSMEDAVQILQQCED-----LVKLKIRKDE    621  

PDZ: domain 6 of 7, from 644 to 718: score 76.1, E = 4.2e-18
                   *->gglGfsivg......gifvssvvpGspAakaGrkslglLkvGDvIle
                      g+lG++i+g++++ ++i++ss+ +G+ A++ G      +++GD+Il+
   mKIAA4223   644    GPLGITISGteepfdPIIISSLTKGGLAERTGA-----IHIGDRILA 685  

                   VNGetsvegltheeavdllkkaggggvGekvtLtvlRgg<-*
                   +N   s++g++  ea+ ll+ ag+     +vtL+++++    
   mKIAA4223   686 INS-SSLKGKPLSEAIHLLQMAGE-----TVTLKIKKQT    718  

PDZ: domain 7 of 7, from 962 to 1034: score 58.8, E = 6.8e-13
                   *->gglGfsivg.....gifvssvvpGspAakaGrkslglLkvGDvIleV
                      + +Gfs++++  ++g++v+++ p +p +  G      Lk+ D++l+V
   mKIAA4223   962    EDFGFSVADgllekGVYVKNIRPAGPGDVGG------LKPYDRLLQV 1002 

                   NGetsvegltheeavdllkkaggggvGekvtLtvlRgg<-*
                   N  + +++++   +v l+ ++g+     k++L++ R++   
   mKIAA4223  1003 NH-VRTRDFDCCLVVPLIAESGN-----KLDLVISRNP    1034 

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