hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/smart.HMMs
Sequence file:            /cdna4/rodent/full/goal/mbg/mbg04678/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA4219  ( 918 res)   mbg04678

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
SPEC     Spectrin repeats                               472.2   2.5e-137   6
PH       Pleckstrin homology domain.                     68.1    1.1e-15   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
SPEC       1/6      70   170 ..     1   104 []    95.5  6.2e-24
SPEC       2/6     176   276 ..     1   104 []    95.3  7.4e-24
SPEC       3/6     282   383 ..     1   104 []    95.8  4.9e-24
SPEC       4/6     389   489 ..     1   104 []    67.8  1.4e-15
SPEC       5/6     495   595 ..     1   104 []    99.0  5.5e-25
SPEC       6/6     601   782 ..     1   104 []    45.4  7.7e-09
PH         1/1     769   880 ..     1    82 []    68.1  1.1e-15

Alignments of top-scoring domains:
SPEC: domain 1 of 6, from 70 to 170: score 95.5, E = 6.2e-24
                   *->qqFlrdadeleaWleekeqllssedlgeskDlesveallkkHqalea
                       q  rd++++  W+ee  +l++s d+g    l++v+  +kk q+l++
   mKIAA4219    70    LQISRDLEDETLWVEERLPLAQSADYG--TNLQTVQLFMKKNQTLQN 114  

                   elaaheervdalnelgeqLieesghpdaeeIeerleeLnerWeeLlelae
                   e+  h++rv+++ + g++L+++  + d ++Ieerl +L++ W+ L+e+a+
   mKIAA4219   115 EILGHAPRVEDVLRRGQELVKA-AEIDCQDIEERLGHLQSSWDTLREAAA 163  

                   eRrqkLe<-*
                    R q+L    
   mKIAA4219   164 GRLQRLR    170  

SPEC: domain 2 of 6, from 176 to 276: score 95.3, E = 7.4e-24
                   *->qqFlrdadeleaWleekeqllssedlgeskDlesveallkkHqalea
                      qq++ da e+eaW++e+e ++ s++++  kD+e++ ++lk+H + ++
   mKIAA4219   176    QQYYLDAGEAEAWISEQELYVFSDEPP--KDEEGAIVMLKRHLRQQR 220  

                   elaaheervdalnelgeqLieesghpdaeeIeerleeLnerWeeLlelae
                    +++++  +++l   ++ L+++ ghp+ e+I + + +++++++ L+++ae
   mKIAA4219   221 TVEEYGRNIKQLAGRAQSLLSA-GHPEGEQIIRLQGQVDKQYAGLKDMAE 269  

                   eRrqkLe<-*
                   eRr++Le   
   mKIAA4219   270 ERRRRLE    276  

SPEC: domain 3 of 6, from 282 to 383: score 95.8, E = 4.9e-24
                   *->qqFlrdadeleaWleekeqllssedlgeskDlesveallkkHqalea
                      +q+ r+ad+le+W++eke ++ss+++g  +D ++v  l +k+ ++ +
   mKIAA4219   282    FQLKREADDLEQWITEKEMVASSQEMG--QDFDHVTMLRDKFRDFAR 326  

                   el.aaheervdalnelgeqLieesghpdaeeIeerleeLnerWeeLlela
                   e +a  +ervd++n   e+Li++ gh +a++I e+ + Ln+ W++Llel 
   mKIAA4219   327 ETgAIGQERVDNVNTIIERLIDA-GHSEAATIAEWKDGLNDMWADLLELI 375  

                   eeRrqkLe<-*
                   + R q L    
   mKIAA4219   376 DTRMQLLA    383  

SPEC: domain 4 of 6, from 389 to 489: score 67.8, E = 1.4e-15
                   *->qqFlrdadeleaWleekeqllssedlgeskDlesveallkkHqalea
                      ++++    e++  ++ek + l  ed+g   D +++e+  + H a+e+
   mKIAA4219   389    HRYFYTGTEILGLIDEKHREL-PEDVG--LDASTAESFHRVHTAFER 432  

                   elaaheervdalnelgeqLieesghpdaeeIeerleeLnerWeeLlelae
                   el   + +v++ ++ + +L  ++ ++ a++I+ + +e+ ++W++Ll++++
   mKIAA4219   433 ELHLLGVQVQQFQDVATRLQTAYAGEKADAIQSKEQEVSAAWQALLDACA 482  

                   eRrqkLe<-*
                    Rr++L    
   mKIAA4219   483 GRRAQLV    489  

SPEC: domain 5 of 6, from 495 to 595: score 99.0, E = 5.5e-25
                   *->qqFlrdadeleaWleekeqllssedlgeskDlesveallkkHqalea
                      ++F++ +++l++W+e+  ++ ++++ +  +D++sve llk Hq ++a
   mKIAA4219   495    FRFFSMVRDLLSWMESIIRQIETQERP--RDVSSVELLLKYHQGIKA 539  

                   elaaheervdalnelgeqLieesghpdaeeIeerleeLnerWeeLlelae
                   e+++++  ++++ elge L+++ +h +++eI+e+l+++ +r++e  +++e
   mKIAA4219   540 EINTRAKNFSTCLELGESLLQR-QHQASDEIREKLQQVISRRQEMNDKWE 588  

                   eRrqkLe<-*
                   +R  +L    
   mKIAA4219   589 ARSDRLH    595  

SPEC: domain 6 of 6, from 601 to 782: score 45.4, E = 7.7e-09
                   *->qqFlrdadeleaWleekeqllssedlgeskDlesveallkkHqalea
                       qF rda  +eaWl  +e++l+s d+g  ++++sve+l+k+H+a+e+
   mKIAA4219   601    CQFSRDASVAEAWLIAQEPYLASRDFG--HTVDSVEKLIKRHEAFEK 645  

                   elaaheervdalne.lgeqLieesghpdaeeIeerl..............
                     a ++er+ al++++  +L+e+ + p+ ++ e   +++++++ ++ ++ 
   mKIAA4219   646 STASWAERFAALEKpTTLELKER-QTPERPTEEPGPqeeegetageapqv 694  

                   ..................................................
                   ++  ++++++++++++ +++ ++++ +++++++++++ +++++ +++  +
   mKIAA4219   695 hhaatertspgeergpwpqdlqppplpghhkdeqeksvgderpateplfk 744  

                   ..................eeLnerWeeLlelaeeRrqkLe<-*
                     +++ ++++++++ + +++L +  +   e    R++ Le   
   mKIAA4219   745 vldtplsegdepttlpaqRDLGHTVQ--MEGYLGRKHDLE    782  

PH: domain 1 of 1, from 769 to 880: score 68.1, E = 1.1e-15
                   *->vikeGwLlkks..........k.swkkryfvLfngvLlyyksk....
                      v++eG+L +k++  +++++ +++sw   y+vL+n++L++yk+ ++  
   mKIAA4219   769    VQMEGYLGRKHdlegpnkkasNrSWNNLYCVLRNSQLTFYKDAknla 815  

                   .....kpkgsipLsgcsvre.p.......cFeivt.dr.tlllqAeseee
                    + +    +++ L++++++  ++ ++++++F+++ ++++++l++ ++eee
   mKIAA4219   816 lgvpyHGEEPLALRHAICEIaVnykkkkhVFKLRLsNGsEWLFHGKDEEE 865  

                   reeWvealqsaiaka<-*
                   + +W++++  ai+++   
   mKIAA4219   866 MLMWLQSMSTAINES    880  

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