hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data11/genetics/InterProScan/iprscan/data/TIGRFAMs_HMM.LIB Sequence file: /cdna4/rodent/full/goal/mbg/mbg00956/w3open/interpro/cnk_1/seq.in - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: mKIAA4195 ( 1061 res) mbg00956 Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- ATPase-IIA1_Ca ATPase-IIA1_Ca: calcium-translocating 2035.6 0 1 ATPase_P-type ATPase_P-type: ATPase, P-type (transp 424.8 7.7e-124 6 ATPase-IIA2_Ca ATPase-IIA2_Ca: calcium-transporting 361.0 1.2e-104 1 ATPase-IIC_X-K ATPase-IIC_X-K: Na,H/K antiporter P-t 329.7 3.4e-95 1 ATPase-IID_K-Na ATPase-IID_K-Na: potassium/sodium eff 96.7 4.6e-25 1 ATPase-IIB_Ca ATPase-IIB_Ca: calcium-translocating 57.4 6.3e-23 1 ATPase-IB_hvy ATPase-IB_hvy: heavy metal translocat 28.1 3.4e-14 1 T_den_put_tspse T_den_put_tspse: conserved hypothetic 8.4 0.28 1 ATPase-IIIA_H ATPase-IIIA_H: plasma-membrane proton -55.8 9.8e-26 1 ATPase-IIIB_Mg ATPase-IIIB_Mg: magnesium-translocati -145.6 1.8e-13 1 ATPase-IB2_Cd ATPase-IB2_Cd: cadmium-translocating -233.5 2.1e-06 1 ATPase-IB1_Cu ATPase-IB1_Cu: copper-translocating P -330.5 0.00013 1 kdpB kdpB: K+-transporting ATPase, B subun -445.5 0.00035 1 P-ATPase-V P-ATPase-V: P-type ATPase of unknown -474.6 0.89 1 ATPase-Plipid ATPase-Plipid: phospholipid-transloca -710.0 0.0034 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- T_den_put_tspse 1/1 35 49 .. 298 314 .] 8.4 0.28 ATPase_P-type 1/6 110 210 .. 1 97 [. 88.0 1.9e-22 ATPase_P-type 2/6 220 388 .. 92 237 .. 126.4 5.3e-34 ATPase_P-type 3/6 497 545 .. 254 295 .. 6.8 1.1 ATPase_P-type 4/6 608 658 .. 316 366 .. 69.7 3.1e-17 ATPase-IB1_Cu 1/1 85 796 .. 1 545 [] -330.5 0.00013 ATPase_P-type 5/6 692 797 .. 366 466 .. 138.6 1.1e-37 ATPase-IB_hvy 1/1 75 823 .. 1 639 [] 28.1 3.4e-14 ATPase_P-type 6/6 802 823 .. 455 478 .] 4.8 3.6 ATPase-IB2_Cd 1/1 86 825 .. 1 494 [] -233.5 2.1e-06 kdpB 1/1 54 833 .. 1 675 [] -445.5 0.00035 ATPase-IIIA_H 1/1 40 933 .. 1 835 [] -55.8 9.8e-26 ATPase-IIB_Ca 1/1 1 967 [. 1 885 [] 57.4 6.3e-23 ATPase-IIIB_Mg 1/1 6 968 .. 1 892 [] -145.6 1.8e-13 P-ATPase-V 1/1 3 990 .. 1 1350 [] -474.6 0.89 ATPase-IIA1_Ca 1/1 70 1005 .. 1 800 [] 2035.6 0 ATPase-IIA2_Ca 1/1 19 1008 .. 1 856 [] 361.0 1.2e-104 ATPase-IID_K-Na 1/1 16 1013 .. 1 1001 [] 96.7 4.6e-25 ATPase-Plipid 1/1 72 1018 .. 1 1249 [] -710.0 0.0034 ATPase-IIC_X-K 1/1 6 1021 .. 1 998 [] 329.7 3.4e-95 Alignments of top-scoring domains: T_den_put_tspse: domain 1 of 1, from 35 to 49: score 8.4, E = 0.28 *->vaeatgdeLSeeeleei<-* v+e tg LS+e+++++ mKIAA4195 35 VNESTG--LSLEQVKKL 49 ATPase_P-type: domain 1 of 6, from 110 to 210: score 88.0, E = 1.9e-22 *->viliivllfvlletlqkeaaedalrslkdkelnpqkvtvlrng...g vil+i++++++++++q+++ae+a+++lk+ +p++ +v+r++++++ mKIAA4195 110 VILLILVANAIVGVWQERNAENAIEALKE--YEPEMGKVYRQDrksV 154 veisskdlvvGDiVlvkkGdivPADgvLLs...gscyVdessLTGEsnpv ++i++kd+v+GDiV+++ Gd+vPAD++L s +++++ Vd+s+LTGEs+ v mKIAA4195 155 QRIKAKDIVPGDIVEIAVGDKVPADIRLTSiksTTLRVDQSILTGESVSV 204 lKtdap<-* +K+ +p mKIAA4195 205 IKHTDP 210 ATPase_P-type: domain 2 of 6, from 220 to 388: score 126.4, E = 5.3e-34 *->lKtdapfagtynfnGtltlkvskiav..........vvytgfektpl +K+++ f+gt++ G++ ++v++ +v+++ ++ ++++v t +e+tpl mKIAA4195 220 DKKNMLFSGTNIAAGKAMGVVVATGVnteigkirdeMVATEQERTPL 266 qrkldrlafifilfllllalsvflltliglwt..........ffkiflra q+kld+++ + +++ l++++v+++ + +++++ ++++ ++ +++f +a mKIAA4195 267 QQKLDEFGEQLSKVISLICIAVWIINIGHFNDpvhggswirgAIYYFKIA 316 lillviaiPiaLpvavtialavgdkrma...ilvrslnalEelGqvdyic ++l+v+aiP++Lp+++t++la+g++rma+++++vrsl+++E+lG+ ++ic mKIAA4195 317 VALAVAAIPEGLPAVITTCLALGTRRMAkknAIVRSLPSVETLGCTSVIC 366 sDKTGTLTenkmtfkkvyigge<-* sDKTGTLT+n+m++ ++ i + mKIAA4195 367 SDKTGTLTTNQMSVCRMFILDK 388 ATPase_P-type: domain 3 of 6, from 497 to 545: score 6.8, E = 1.1 *->kildvlpFtSerKrMsvivrdpdgk.......yvKGApevilercsd k+ ++l+F+ +rK Msv + ++ ++++ ++ +vKGApe + rc++ mKIAA4195 497 KKEFTLEFSRDRKSMSVYCTPNKPSrtsmskmFVKGAPEGVIDRCTH 543 te<-* ++ mKIAA4195 544 IR 545 ATPase_P-type: domain 4 of 6, from 608 to 658: score 69.7, E = 3.1e-17 *->ellGltaieDpLredvketIeeLkraGikvwMlTGDnveTAiaIAke +++G++++ Dp+r +v+ +++++++aGi+v+M+TGDn++TA+aI+++ mKIAA4195 608 TFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGTAVAICRR 654 cglf<-* +g+f mKIAA4195 655 IGIF 658 ATPase-IB1_Cu: domain 1 of 1, from 85 to 796: score -330.5, E = 0.00013 *->aGrpFYksAwkaLrhkapnMDtLIaLGTtvAYlySlvalhtfFdasa a+ ++ Aw + +++ +f + ++ mKIAA4195 85 AACISFVLAWFEEGEETIT---------------------AFVEPFV 110 mLitfiL...LGrwLEelAkgrasdAlskLakLqPetAtlltdd...... L+ ++ + +G w E +A A+++L + Pe ++ ++d+++ ++ mKIAA4195 111 ILLILVAnaiVGVWQERNA----ENAIEALKEYEPEMGKVYRQDrksvqr 156 vpvaelqpGDivkVlPGekiPVDGtVieGeSe...vDESlvTGESlPVpK ++ +++ pGDiv+++ G+k+P+D + ++ S++ +vD+S +TGES+ V K mKIAA4195 157 IKAKDIVPGDIVEIAVGDKVPADIRLTSIKSTtlrVDQSILTGESVSVIK 206 kvGDtV..............iaGTvNgtGsLvvkaTkvGedttLaqIvel + D+V++++ ++++++ ++GT G + ++G +t + +I mKIAA4195 207 HT-DPVpdpravnqdkknmlFSGTNIAAGKAMGVVVATGVNTEIGKIRDE 255 VrqAQqsKApiqr....lADkvAgyFVPvviaiAilTfviWlf....... + +q++ p q++ +++ ++++ +i ++ +++W+++ ++ ++ mKIAA4195 256 MVATEQERTPLQQkldeFGEQLSK-------VISLICIAVWIInighfnd 298 ..........ALeta.VtV.LiIACPCALGLAtP........tvimVaTG + ++++ ++A+ +++++V L +A A+P++ + +t + +T mKIAA4195 299 pvhggswirgAIYYFkIAVaLAVA-------AIPeglpavitTCLALGTR 341 vaAknGvLiKdgdALErAanidtVvFDKTGTLTqGkptVtdvkvfsds.. ++Ak ++++ + E + +++++ DKTGTLT+ ++ V ++++++ mKIAA4195 342 RMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDKVeg 391 .....................................lLalaaaLEasSe ++ + ++ + ++++ + ++ ++++++ + ++ ++ La++ aL ++S mKIAA4195 392 dtcslnefsitgstyapigevqkddkpvkchqydglvELATICALCNDSA 441 HPl....AkAIvs......................YakGkG......... l+ ++Ak++ ++ ++ +++ + ++ + ++++kG+++ ++ + + mKIAA4195 442 --LdyneAKGVYEkvgeatetaltclvekmnvfdtELKGLSkieranacn 489 ........................................vegtveG... + ++ +++ + + ++++++ + +++++++++ ++ v+g+ eG + mKIAA4195 490 svikqlmkkeftlefsrdrksmsvyctpnkpsrtsmskmfVKGAPEGvid 539 tkhkiqlGNek.............................llgengiktd + i++G+ k + +++ +++ + ++ ++++++ + l+ +++ + mKIAA4195 540 RCTHIRVGSTKvpmtpgvkqkimsvirewgsgsdtlrclaLATHDNPLKR 589 eaaeggttsvlvavngeLagvlala..DqlkPeakevIqaLkrrGIepvM e+ ++ + ++ L++v ++ D+++ e+++ ++ ++ GI+++M mKIAA4195 590 EEMHLEDSANFIKYETNLTFVGCVGmlDPPRIEVASSVKLCRQAGIRVIM 639 LTGDNrktAkavAkeLGI.....nv......................... +TGDN+ tA a+ +++GI +++++v+++ ++++ ++ +++ +++ + mKIAA4195 640 ITGDNKGTAVAICRRIGIfgqdeDVtskaftgrefdelspsaqrdaclna 689 ..rAeVlPddKaalikelqe..kvVaMVGDGINDAPALAqADVGIAigaG + +A V P +K+ +++ lq+ ++++aM GDG+NDAPAL + +GIA+g+G mKIAA4195 690 rcFARVEPSHKSKIVEFLQSfdEITAMTGDGVNDAPALKKSEIGIAMGSG 739 tDVAieaADiVLlnd.LkdVataIdlSrkTlrrikqNLlWAlgYNviaIP t VA++a+ VL +d+ + +++a++ r+ + ++kq mKIAA4195 740 TAVAKTASEMVLADDnFSTIVAAVEEGRAIYNNMKQ-------------- 775 iAAGvlyPaggilLsPavAgaAMalSSVs..VVlNalrLr<-* ++ ++ SS +++VV+ l+ mKIAA4195 776 -----FIRYL--------------ISSNVgeVVCIFLTAA 796 ATPase_P-type: domain 5 of 6, from 692 to 797: score 138.6, E = 1.1e-37 *->fARvsPeqKaeiVellqkrgaiVamiGDGaNDapALkaADVGiaig. fARv P++K iVe lq ++i+am+GDG+NDapALk++ +Gia+g+ mKIAA4195 692 FARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKSEIGIAMGs 738 ....AkaaaDivltddnlslivlllvhGRwtykrikklilyalyynlili ++ Ak a+ +vl+ddn+s+iv ++++GR +y+++k++i y++++n++++ mKIAA4195 739 gtavAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEV 788 illfvlsvi<-* +++f+ +++ mKIAA4195 789 VCIFLTAAL 797 ATPase-IB_hvy: domain 1 of 1, from 75 to 823: score 28.1, E = 3.4e-14 *->mDtLmalAaiaAyamglvlega......hafFdtsvlLlflfllGet D+L+ + ++A++++ vl+ ++++++++ F ++ ++l+++ + mKIAA4195 75 EDLLVRI-LLLAACISFVLAWFeegeetITAFVEPFVILLILVANAI 120 LEerAkgrasralsaLlaLaPstArvlqgdGelqdnddseeeVpveelqv + + a a++aL++ P+ v+++d s++++++ ++++ mKIAA4195 121 VGVWQERNAENAIEALKEYEPEMGKVYRQDRK------SVQRIKAKDIVP 164 GDivvVrpGEriPVDGeVisGese...vDESaLTGESmPVeKkeG..... GDiv++ G+++P+D ++ s +s++ +vD+S LTGES+ V K + + +++ mKIAA4195 165 GDIVEIAVGDKVPADIRLTSIKSTtlrVDQSILTGESVSVIKHTDpvpdp 214 ........deVfAGtiNgdGsLtirvTktgedstlaqIveLVeeAqssKa + +++++ f+Gt G +v +tg ++ +++I + +++++ mKIAA4195 215 ravnqdkkNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERT 264 piqrlaDriasyyvpavlaiAlltflvwlalgarpFvieklvAffgyrkl p+q+ +D ++ ++++++ +i ++++++ + +++p + mKIAA4195 265 PLQQKLDEFGEQLSKVISLICIAVWIINIGHFNDPV-------------H 301 ksdnvrealyr...AvaVLvvACPCALgLAtPvAilvAigaAArrGvLiK ++++r+a+y+ + Ava+ v+A P +L +++ ++ ++ ++A++ +++ mKIAA4195 302 GGSWIRGAIYYfkiAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVR 351 gGaaLEkLakvktVvFDKTGTLTtGkptVvdieplddssqgksgiseeel + ++E+L+ +++++ DKTGTLTt +++V +ld++++++ ++l mKIAA4195 352 SLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDKVEGDT-----CSL 396 LaalAaalEqsSsHPlArAIvryakkEgsderglelpkvs.....e.... + ++ s + P+++ +++ + + + ++ ++ e + mKIAA4195 397 NE---FSITGSTYAPIGE-VQK---------DDKPVKCHQydglvElati 433 .................................................. +++ + ++ ++ ++ ++ +++ + ++ + +++ ++ ++ + mKIAA4195 434 calcndsaldyneakgvyekvgeatetaltclvekmnvfdtelkglskie 483 .................................................. + + ++ ++ +++ + + ++++++ + +++++++++ ++ ++ mKIAA4195 484 ranacnsvikqlmkkeftlefsrdrksmsvyctpnkpsrtsmskmfvkga 533 ............eavedveevpGkGvsakvdgqet...arevriGnprfm +++ ++ ++ + ++v + pG ++ + re+ G++++ mKIAA4195 534 pegvidrcthirVGSTKVPMTPGVKQ-------KImsvIREWGSGSDTL- 575 geIdleldaeenekelkaskellnegisqgktvvlvavdgkellGvialr ++ a + ++++ + ++ + ++ + + ++ + +++G++ + mKIAA4195 576 -----RCLALAT---HDNPLKREEMHLEDSANFIKYETNL-TFVGCVGML 616 DqlRpeakeaiaaLkrkgGiievvmLTGDnraaAeavAaeLGI....... D++R e++ ++ +++g i+v m+TGDn+ +A a+ ++ GI +++++ mKIAA4195 617 DPPRIEVASSVKLCRQAG--IRVIMITGDNKGTAVAICRRIGIfgqdedv 664 ........eidev..............hAellPeDKlaiVkelqaerySe +++ +++e+de +++ +++ + + +A + P +K +iV+ lq mKIAA4195 665 tskaftgrEFDELspsaqrdaclnarcFARVEPSHKSKIVEFLQ------ 708 egghvVaMVGDGiNDAPALAaAdVGIAmGasGsDvAieaADiVLlndndL + ++aM GDG+NDAPAL+ + +GIAmG sG++vA+ a+ VL +d + mKIAA4195 709 SFDEITAMTGDGVNDAPALKKSEIGIAMG-SGTAVAKTASEMVLADD-NF 756 sslptaidlSrktrriikQNlawAlgynlv....aiplAaggllplwgll s +++a++ r+ ++kQ + ++ n+ + + + Aa+g+ ++ + mKIAA4195 757 STIVAAVEEGRAIYNNMKQFIRYLISSNVGevvcIFLTAALGFPEAL-I- 804 LsPllAvllhegStvlVvLNsLRL<-* P+ + +++ L + +L mKIAA4195 805 --PVQLLWVNLVTD---GLPATAL 823 ATPase_P-type: domain 6 of 6, from 802 to 823: score 4.8, E = 3.6 *->iliillfvlsvinllftslpalal<-* +li++++++ +nl++++lpa al mKIAA4195 802 ALIPVQLLW--VNLVTDGLPATAL 823 ATPase-IB2_Cd: domain 1 of 1, from 86 to 825: score -233.5, E = 2.1e-06 *->vDlLmaiAalgala......iGellEaAlllllfsigetLeeyAarr ++i ++a++++++++i + E+ ++ll++ + + + r mKIAA4195 86 ----ACISFVLAWFeegeetITAFVEPFVILLILVANAIVGVWQERN 128 arralkaLlelaPdtArvvq......eeVaveelqvGDvvvVkpGErvPv a++a++aL+e P+ v+++++++ +++++ ++++GD+v+ G++vP+ mKIAA4195 129 AENAIEALKEYEPEMGKVYRqdrksvQRIKAKDIVPGDIVEIAVGDKVPA 178 DGkvlsGeal...vDesaLTGESvPVekapG.............deVfAG D ++ s ++++ +vD+s LTGESv V k ++ ++++ +++++ +f+G mKIAA4195 179 DIRLTSIKSTtlrVDQSILTGESVSVIKHTDpvpdpravnqdkkNMLFSG 228 tiNldGvltievtklgadStiakIieLVeeAqsnKaktqRfiDrfaryYt t + G +v ++g ++ i+kI + + + +++++q+ +D+f+++++ mKIAA4195 229 TNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLS 278 plvlliallval...................vpgsltAlvlLvvAsPCAL +++ li ++v++ + ++ +++ ++++ ++ + ++ +A++l v+A P +L mKIAA4195 279 KVISLICIAVWIinighfndpvhggswirgaIYYFKIAVALAVAAIPEGL 328 viStPvAylaAIsaAARhGiLiKGGaaLEkLakvktvaFDKTGTLTtGkp + ++ + + + A++ ++++ +E+L+ + + DKTGTLTt++ mKIAA4195 329 PAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQM 378 kVvdveple.......................................lL +V + +l++ ++++ + ++ + ++++ + ++ ++++++ + ++ ++l+ mKIAA4195 379 SVCRMFILDkvegdtcslnefsitgstyapigevqkddkpvkchqydgLV 428 rlaa........................aaEqqSsHPlArAIvaaeevpG la+ +++ + ++ ++ ++ ++a E + + + + v +e+ G mKIAA4195 429 ELATicalcndsaldyneakgvyekvgeATETALTCLVEKMNVFDTELKG 478 .................................................. ++ ++ + ++ ++ +++ + + ++++++ + +++++++++ ++ mKIAA4195 479 lskieranacnsvikqlmkkeftlefsrdrksmsvyctpnkpsrtsmskm 528 ......eGvkAvvdgeevriGnk..........................r ++ +eGv ++ +r+G+ + + +++ +++ + ++ ++++++ r mKIAA4195 529 fvkgapEGVIDRC--THIRVGSTkvpmtpgvkqkimsvirewgsgsdtlR 576 tlvlVavdg......................kliGvillsDelRpeAaea l+l+ d++ ++++ + +++ + + +++ +++G +++ D++R e+a mKIAA4195 577 CLALATHDNplkreemhledsanfikyetnlTFVGCVGMLDPPRIEVASS 626 iaeLkalGvkkivmLTGDrravAeavAaeLG..................d ++ ++ G +++m+TGD++ +A a+ +++G +++++ +++ ++++ d mKIAA4195 627 VKLCRQAG-IRVIMITGDNKGTAVAICRRIGifgqdedvtskaftgrefD 675 eV..............hAeLlPEDKleiVkelqk....vaMVGDGiNDAP e +++ +++ + + +A P K +iV+ lq ++ +aM GDG+NDAP mKIAA4195 676 ELspsaqrdaclnarcFARVEPSHKSKIVEFLQSfdeiTAMTGDGVNDAP 725 ALAaADVGIAMGasGsdvAlEtADiVLldddLsrlpeairlArrtrriik AL+ + +GIAMG sG++vA+ ++ VL dd+ s ++ a++ r ++k mKIAA4195 726 ALKKSEIGIAMG-SGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMK 774 QNvvlAlgiila....lillalfGvlpLwlAVllHeGsTvLViLNalRlL Q + ++ ++ + + l a++G+ +++ V l + v +L a l mKIAA4195 775 QFIRYLISSNVGevvcIFLTAALGFPEALIPVQLLWVNLVTDGLPATALG 824 r<-* mKIAA4195 825 F 825 kdpB: domain 1 of 1, from 54 to 833: score -445.5, E = 0.00035 *->krKkaklitkdilvrAikeAfkKLNPkaairNPVMFvVwVGslvTll + + + l++ ++e f L +V + l+ + mKIAA4195 54 GSNELPAEEGKTLLELVIEQFEDL------------LVRI-LLLAAC 87 vtIapalFgtkgkNlrlFnaivtgiLFiTVLFANFAEAvAEGRgKAQA.d ++ a F F + L +L AN v R A + mKIAA4195 88 ISFVLAWFEEGEETITAFVEPFVILL---ILVANAIVGVWQERNAENAiE 134 aLkktkketlAklLsddga.ikkVpAdeLkkGDvVlVeaGDVIPaDGEV. aLk e + k + d ++++ + A + GD+V + GD +PaD + mKIAA4195 135 ALKEYEPE-MGKVYRQDRKsVQRIKAKDIVPGDIVEIAVGDKVPADIRLt 183 .ieGvA.SVDESAITGESAPVlk..ESGgDfASVT........GGTrivS +i VD S TGES V+k++ + D V +++++ GT i mKIAA4195 184 sIKSTTlRVDQSILTGESVSVIKhtDPVPDPRAVNqdkknmlfSGTNIAA 233 DwLvVevtadPGesFL....DrMIaLVEGAeRrKTPNEiALtvLLvaLtL v a+ + +++ +D M+a e TP L L+ mKIAA4195 234 GKAMGVVVATGVNTEIgkirDEMVA----TEQERTPLQQKLDEFGEQLSK 279 VFLlvvatLypfAa.......Yagvkis.....vsvLVALLVcLIPTTIG V l+ + + ++ +++ +g i + + VAL V+ IP mKIAA4195 280 VISLICIAVWIINIghfndpvHGGSWIRgaiyyFKIAVALAVAAIPEGLP 329 GLLSAIGiAGMdRvlrfNVIAtSGrAVEAcGDVdtLvLDKTGTITlGNRl G R+++ N I S VE G ++ DKTGT T N + mKIAA4195 330 AVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTT-NQM 378 ..AeeFI................................pvqGvdkkkla + FI ++ ++++ + ++ + ++++ + ++ +++++pv + l+ mKIAA4195 379 svCRMFIldkvegdtcslnefsitgstyapigevqkddkPVKCHQYDGLV 428 dvAvlASlaDdTP....EGkSIVe............LAkqLgiriddkks A ++ l d + +E k + e+ ++ +++ + L +++++ k mKIAA4195 429 ELATICALCNDSAldynEAKGVYEkvgeatetaltcLVEKMNVFDTELKG 478 es..............aeFveFtAq.tR....MSGinLdn.......Gre +s+ ++ + ++ ++ eFt +R++++MS +n++++++ ++ mKIAA4195 479 LSkieranacnsvikqLMKKEFTLEfSRdrksMSVYCTPNkpsrtsmSKM 528 vrKGA.vDAIkk....fVeerkGripkdlDeavdqVAkqGgT........ KGA+ + I + ++ +V + k +++ + +++ V + g ++++ + mKIAA4195 529 FVKGApEGVIDRcthiRVGSTKVPMTPGVKQKIMSVIREWGSgsdtlrcl 578 .......PL....vVcvDnk..........iyGVIyLKDiVKsGikERFe ++++PL++++ +D+ + + +++ + G + D + mKIAA4195 579 alathdnPLkreeMHLEDSAnfikyetnltFVGCVGMLDPPRIEVASSVK 628 qLRkmGikTiMlTGDNrLTAAvIAkEAGV..................... R+ Gi+ iM+TGDN TA +I + G+ +++++ +++ ++++ ++ + mKIAA4195 629 LCRQAGIRVIMITGDNKGTAVAICRRIGIfgqdedvtskaftgrefdels 678 .....DDFi.....AEAtPEdKievIkkeQaeGkLVAMTGDGTNDAPALA ++ ++D ++ + A P K ++ Q AMTGDG NDAPAL mKIAA4195 679 psaqrDACLnarcfARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALK 728 QAdVgvAMNsGTqAAKEAANMVDLDSdPTKlieVVeIGKQLLiTRGALTT ++g+AM sGT AK A MV D + ++ Ve G mKIAA4195 729 KSEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGR----------- 767 FSiANDVAKYFAIIPaiFAaAiPkLqaLNiMnLsspdSAiLSAlIFNALI i N K F + + L + N+ L A AL mKIAA4195 768 -AIYNNM-KQF--------IRY--LISSNVGEVVCI---FLTA----ALG 798 Ip.aLIPLALKGVkYrPLtAeaLLrRNlliYGLGGvivPFiGIKvIDlLi p+aLIP+ +LL Nl GL + G Dl i mKIAA4195 799 FPeALIPV-------------QLLWVNLVTDGLP---ATALGFNPPDLDI 832 T<-* mKIAA4195 833 M 833 ATPase-IIIA_H: domain 1 of 1, from 40 to 933: score -55.8, E = 9.8e-26 *->GLtsaEAkkRLakYGpNelp.EkKvspllkFLsfmWnPlsWvmEaAA GL+ + +kk+ + +G Nelp E+ + l+ ++++ l + AA mKIAA4195 40 GLSLEQVKKLKERWGSNELPaEEGKTLLELVIEQFEDLLVRILLLAA 86 IiaiaLenGgGkaPDWvDF..........viIlgLLLlNatIGFiEEnkA i+++L+ + ++++ + ++ +Il++L++Na +G ++E++A mKIAA4195 87 CISFVLAW-------FEEGeetitafvepFVILLILVANAIVGVWQERNA 129 GNAVeaLKqsLApkAkVlR.DGk.WqeipAkeLVPGDvVrLklGDiVPAD +NA+eaLK kV R+D k+ q i Ak+ VPGD+V ++ GD VPAD mKIAA4195 130 ENAIEALKEYEPEMGKVYRqDRKsVQRIKAKDIVPGDIVEIAVGDKVPAD 179 crLfeGdpqHPFDHEEvyikvDQAALTGESLPVtKkiG............ +rL + + + vDQ+ LTGES V K++++ ++++ ++++ mKIAA4195 180 IRLTSIKS--------TTLRVDQSILTGESVSVIKHTDpvpdpravnqdk 221 .DiaySGStVKqGEaeavVtATGmNTFFGkAAaLVqstetgsGHlQkiLs + + +SG ++++G a +vV+ATG+NT Gk te++ lQ+ L mKIAA4195 222 kNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLD 271 kIGlfLivligvlvlielvvlffgrgesfrege..eG.CltlqfaLVLLV G L i+++++ ++++ +++ + ++g G + a++L+V mKIAA4195 272 EFGEQLSKVISLICIAVWIINIGHFNDPVHGGSwiRGaIYYFKIAVALAV 321 gGIPIAmPaVLSVTMAvGAaeLAkkkAIVtRLtAIEELAGMDILCSDKTG ++IP ++PaV ++ +A+G ++ Akk AIV L ++E L + CSDKTG mKIAA4195 322 AAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTG 371 TLTlNKLsideilpffggGpgfdkdDVllyAALAskwreenqDAIDtavl TLT+N++s+ + +f +d ++e+ Dt+ l mKIAA4195 372 TLTTNQMSV---CRMFI----LD--------------KVEG----DTCSL 396 gslkdlkrlkearagykvleFvPFdHPVdKRTeatvedpetGkkfkvtKG + + ++ + P+ V+K + + +G + +t mKIAA4195 397 N---EFS--------ITGSTYAPIG-EVQKDDKPVKCHQYDGLVELAT-- 432 APqvILdlcdnk.......keieeevr....................... I +lc+++ + ++ k + e+v + +++ + ++ + +++ ++ mKIAA4195 433 ----ICALCNDSaldyneaKGVYEKVGeatetaltclvekmnvfdtelkg 478 .................................................. ++ ++ + ++ ++ +++ + + ++++++ + +++++++++ ++ mKIAA4195 479 lskieranacnsvikqlmkkeftlefsrdrksmsvyctpnkpsrtsmskm 528 ..............................ekVeekveeLAsRG...yRA ++ +++ ++ ++ + ++++ + +++ ++k+ + e s G++++R+ mKIAA4195 529 fvkgapegvidrcthirvgstkvpmtpgvkQKIMSVIREWGS-GsdtLRC 577 LGVArtEVPsg......ekadekgrWh....flGLLPlfDPPRhDTkeTI L+ A P ++++ + e+ + + +++++ +f+G + +DPPR + + mKIAA4195 578 LALATHDNPLKreemhlEDSANFIKYEtnltFVGCVGMLDPPRIEVASSV 627 erArelGVeVKMVTGDhlAIAKETARrLGl..GtnIynadvLlkadnrdk + +r+ G++V M+TGD + A ++Rr G+ + + +++ + + + mKIAA4195 628 KLCRQAGIRVIMITGDNKGTAVAICRRIGIfgQDEDVTSKAFTGREFDEL 677 lpsgaeedlgElVEsADGFAeVFPEHKYeIVeiLQkrGHlVGMTGDGVND +ps + ++A FA V P HK +IVe LQ + +++MTGDGVND mKIAA4195 678 SPSA----QRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVND 723 APALKKADvGIAVaGATDAARsAADIVLTePGLSvIveAileSRkIFQRM APALKK +GIA T A+ A+ +VL S+Iv A+ e R+I M mKIAA4195 724 APALKKSEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNM 773 ksYviYriAeTiRivvfFgllililkPrdYnSvdarfypfpp.imvvii. k ++ Y i+ + vv ++l +++l ++ +p++++ v + mKIAA4195 774 KQFIRYLISSNVGEVVCIFL-TAALG-------FPEAL-IPVqLLWVNLv 814 .......Ai.LN..DGtImTIAyDrVkpSklPer.....WnLrevFtmst +++ + +A+++N++D Im kp+++P ++ ++W ++ ++++ mKIAA4195 815 tdglpatALgFNppDLDIMN------KPPRNPKEplisgWLFFRYLAIGC 858 vLGlylviSTflllaialdGWGEeTyPT....sfFidkfglrllhgnpkd G+ v++ + + ia d ++++ sf+ ++l+ + +n mKIAA4195 859 YVGAATVGAAAWWF-IAAD--------GgprvSFYQLSHFLQCKEDN--- 896 pqyfCiRGAeLqsliYLkvSisgqatIFVtRtrGffwmerkPGkLLfiAf p++ ++ +i+ ++ m+++ + L+ i mKIAA4195 897 PDFD-----GVDCAIF----------------ESPYPMTMALSVLVTIEM 925 viaqiiaTfiavy<-* + a ++++ mKIAA4195 926 CNA-----LNSLS 933 ATPase-IIB_Ca: domain 1 of 1, from 1 to 967: score 57.4, E = 6.3e-23 *->eesvreetsiedavidefdvsvsielkLtdilkvyeklGgaeGiatK + + + ++++ + v e lG mKIAA4195 1 --------ARRPRGREARPAGAPAAMENAHTKTVEEVLGHFG----- 34 LktdlneGvrsstlerRekvYGkNeLPekppkSFLqlVweAlsDktLiLL ++ +G++ + + G NeLP ++ k++L lV e + D +L mKIAA4195 35 --VNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRIL 82 svAAvVSlVvg..eekeeketGWIEGvAILvSVilVVlVtAvNDYkkelq AA S+V ee ee+ t E + IL+ + V e mKIAA4195 83 LLAACISFVLAwfEEGEETITAFVEPFVILLILVANAIVGVWQERNAENA 132 FReLnsrkkeeqkikVIRgGq..eiqIsihdvvVGDivsLstGDvVPADG L + e kV R ++++++ I d+v GDiv GD VPAD mKIAA4195 133 IEALK--EYEPEMGKVYRQDRksVQRIKAKDIVPGDIVEIAVGDKVPADI 180 vf..IsGlklkiDESSiTGES...........dpikKgkvk...LLSGTk +++I+ l +D S +TGES + +++++ +dp ++++k++ L SGT mKIAA4195 181 RLtsIKSTTLRVDQSILTGESvsvikhtdpvpDPRAVNQDKknmLFSGTN 230 VleGsGrMLvTAVGvnSftGklmteLreageee.PLQlkLseLAslIgkf + G + ++v A Gvn++ Gk+ +e + + e++PLQ kL+e + +k mKIAA4195 231 IAAGKAMGVVVATGVNTEIGKIRDEMVATEQERtPLQQKLDEFGEQLSK- 279 GlgsAvLlflvLvlryvieiivedteed....aqtfldlFiiaVTivVVA l+ + +i i ++ ++++ + +F iaV V A mKIAA4195 280 ------VISLICIAVWIINIGHFNDPVHggswIRGAIYYFKIAVALAVAA 323 VPEGLPLAVTlALAYsmkkMmkDnNLVRhLaACETMGsATaICSDKTGTL PEGLP T LA ++ +M k n+ VR L + ET G+ ICSDKTGTL mKIAA4195 324 IPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTL 373 TqNvMsVVqgyI...........geeavrn.................... T+N MsV + +I ++ ++++ + +e ++++++ + ++ ++++++ + ++ mKIAA4195 374 TTNQMSVCRMFIldkvegdtcslNEFSITGstyapigevqkddkpvkchq 423 ......iLvegivlN.ssseevkdggkeefiGsKTEcALLdfglll.... ++ ++ + ++ N+s + + +g e +G TE+AL ++ ++ + mKIAA4195 424 ydglveLATICALCNdSALDYNEAKGVYEKVGEATETALTCLVEKMnvfd 473 .....lrdvqevrkeekvGvk.......iyPFnSeRKkMSvvvkhsgGyR ++ ++l + + v k+ +++ + F+ +RK+MSv R mKIAA4195 474 telkgLSKIERANACNSV-IKqlmkkefTLEFSRDRKSMSVYCTPNKPSR 522 .....lFiKGAsEIvlkkCekvldsnGeakpisdkkdevedvIepl..AS ++ +++F KGA E+v C ++ k + vI ++ S mKIAA4195 523 tsmskMFVKGAPEGVIDRCTHIRVGSTKVPMTPGVKQKIMSVIREWgsGS 572 dALRticLa............yrDelprkdspNkgltliavvGIkDPvRp d+LR + La+++++ ++++ + D + + ++ ++lt+++ vG DP R mKIAA4195 573 DTLRCLALAthdnplkreemhLEDSANFIKYE-TNLTFVGCVGMLDPPRI 621 GVreavqeCQrAGiTVRMVTGDNisTAkAIArnCgILtegg....lamEG +V +v+ C++AGi V M+TGDN TA+AI r gI +++ ++ a G mKIAA4195 622 EVASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGIFGQDEdvtsKAFTG 671 keF.......RkdkILPkLrVLARSsPlDKqLLVe.LkdmGeVVAVTGDG eF++ +++ +d+ L + r AR P K Ve L e A TGDG mKIAA4195 672 REFdelspsaQRDACL-NARCFARVEPSHKSKIVEfLQSFDEITAMTGDG 720 TNDAPALklAdVGFaMGIaGTeVAkeaSDIiLlDDNFaSIVrAVkWGRnV NDAPALk+ +G aMG++ T VAk aS +L DDNF++IV AV GR++ mKIAA4195 721 VNDAPALKKSEIGIAMGSG-TAVAKTASEMVLADDNFSTIVAAVEEGRAI 769 ydsIkKFlQFQLTVNVvAVivtFvGsciSstSPLtAVQLLWVNLIMDTLA y + k F+ NV V+ F+ + + L VQLLWVNL D L mKIAA4195 770 YNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLLWVNLVTDGLP 819 ALALATEpPtEelLdRkPiGRnapLISRsMWknILgqAiYQLvvl..... A AL pP+ ++ +P+ + pLIS L++ Y + + + mKIAA4195 820 ATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAATvgaaa 869 ..fillFaGeeiFTiVFNtFVllQlFneiNARkLeelNv.Feg....lFk fi G+ + Ql + + e N++F g + +F mKIAA4195 870 wwFIAADGGPRV--------SFYQLSHFL---QCKEDNPdFDGvdcaIFE 908 RnaiFvaImlftfgvQViiVeFGGsffStvs....LsieqWilcvllGml +++ + l +++ +e+ + S +++++ L+ W l+G++ mKIAA4195 909 -SPYPMTMALSVLV----TIEMCNALNSLSEnqslLRMPPWENIWLVGSI 953 SLilGvllrliPve<-* L + + + ve mKIAA4195 954 CLSMSLHFLILYVE 967 ATPase-IIIB_Mg: domain 1 of 1, from 6 to 968: score -145.6, E = 1.8e-13 *->nkkqvkklserllkaaamek.EtllrkLdshe.eGLtaaEvterlkk + + + a+ E +l +++ e++GL + v + + mKIAA4195 6 GREARPAGAPAAMENAHTKTvEEVLGHFGVNEsTGLSLEQVKKLKER 52 yGeNrvaeekkspaLvlLlrAFnnPFiyvLaiLagVSYlTDYWLPLRRGE +G N++++e L l + F + + +L a +S++ GE mKIAA4195 53 WGSNELPAEEGKTLLELVIEQFEDLLVRILLLAACISFVL---AWFEEGE 99 EeDLeAvv...iialMVslSgLLrFvQeaRaerAAdALKkMVkntatVLR E+ ++A v++ +i+l + + + +Qe ae A +ALK V R mKIAA4195 100 ET-ITAFVepfVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYR 148 vineNieaaqeevpideLVPGDvikLAAGDliPADvRv..iaArDLfiaQ + + +VPGD++++A GD +PAD+R+++i ++ L + Q mKIAA4195 149 ----QDRKSVQRIKAKDIVPGDIVEIAVGDKVPADIRLtsIKSTTLRVDQ 194 SaLtGESLPvEKyaadkeaAGKDsEqLPDkdkelLeldnLcfMGTnVvSG S+LtGES+ v K ++ +PD + n++f GTn+ G mKIAA4195 195 SILTGESVSVIKHT---DP-------VPDPRAVNQDKKNMLFSGTNIAAG 234 rAqAVVlaTGSsTwFGsLAkavseqdreqtAFdkGVksVSkLLirFMLVM +A VV+aTG T G + + e t + L mKIAA4195 235 KAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLI 284 vPVVLlIN.GysK.....GdWlEAaLF....AlAVAVGLTPEMLPMIVss V +IN G ++ ++G W+ a + + A+A AV PE LP ++++ mKIAA4195 285 CIAVWIINiGHFNdpvhgGSWIRGAIYyfkiAVALAVAAIPEGLPAVITT 334 nLAkGAikmSkkKVIvKrLdAIQNfGAMDiLCTDKTGTLTqDkivLekh. LA G m kk Iv L + +G + C DKTGTLT + + mKIAA4195 335 CLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMf 384 .lD.............vSGkk......................SerVLkl lD+ ++++ + ++ ++ G + + ++ ++++++ + ++ ++ e + mKIAA4195 385 iLDkvegdtcslnefsITGSTyapigevqkddkpvkchqydglVELATIC 434 AwLNSyy.................QtGl......kNvLDrAV..Lekvde A N + + ++ ++ ++ ++ + t l+ ++ Nv D+ ++L k++ mKIAA4195 435 ALCNDSAldyneakgvyekvgeatETALtclvekMNVFDTELkgLSKIER 484 siArs..tkaRwkKvDEiPFdFeRRRlSVvVe....daaeGvrrLicKGA A + k kK + F +R +SV ++++ + ++ KGA mKIAA4195 485 ANACNsvIKQLMKKEFTLEFSRDRKSMSVYCTpnkpSRTS-MSKMFVKGA 533 veEmLtVcThvreggaVvaLdesekerlkdvteelNrqG...lRVvaVAt e ++ cTh+r g v+ + k+++ v e +G+++lR +a At mKIAA4195 534 PEGVIDRCTHIRVGSTKVPMTPGVKQKIMSVIREW-GSGsdtLRCLALAT 582 kkLdaseadPtyskeD.......EeeLiieGyLaFlDPpKestkkAiaaL + + eD+ + + E+ L+ G ++ lDPp + ++ mKIAA4195 583 HDNPLKREE--MHLEDsanfikyETNLTFVGCVGMLDPPRIEVASSVKLC 630 kkngiaVKVLTGDnevVtariClEVGiDAnD......vLlGadiEeLSDe ++ gi V TGDn + iC +Gi D++ +++ +G + eLS mKIAA4195 631 RQAGIRVIMITGDNKGTAVAICRRIGIFGQDedvtskAFTGREFDELSPS 680 eLAaevekravFArLTPmqKeRIvtlLkkeGHtVGFLGDGINDAPALRkA + FAr P +K+ Iv L+ + GDG+NDAPAL k mKIAA4195 681 AQRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKS 730 DVGISVDsAaDIAkeASdiILLEKsLmVLeegVieGRetFgNiLKYLkMT +GI s +Ak AS +L +V eGR ++ N+ +++ mKIAA4195 731 EIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYL 780 ASSNFgNVFSVLVASAFiPFLP..MLaLHLLiQNLLYD.vSQlaLPwDkm SSN g V + A + F P+ ++ LL NL D+ aL + mKIAA4195 781 ISSNVGEVVCIFLTAA-LGF-PeaLIPVQLLWVNLVTDgLPATALGFNPP 828 DkefLkKPrkWdakdlgRFmlfiGPvSSIFDIlTFlLMWyVFaANtveeQ D + + KP + ++k+ + +S ++ yV aA tv + mKIAA4195 829 DLDIMNKPPR-NPKEPL--------ISGWLFFRYLAIGCYVGAA-TVGAA 868 ALFqSGWFVvG....LLsQTLVVHMiRTrk.iP.FIQSRAAl...Pv.ml A WF+ ++++ s H + + + P+F A ++P +m mKIAA4195 869 AW----WFIAAdggpRVSFYQLSHFLQCKEdNPdFDGVDCAIfesPYpMT 914 aTLlVMa.vGiiiPFsPLGasvgLeaLPLSYFPWLiaiLvg.YmlvaQLv + L+V +++ L L P PW Lvg+ +l + L mKIAA4195 915 MALSVLVtIEMCNALNSLSENQSLLRMP----PWENIWLVGsICLSMSL- 959 KrfYirrFgew<-* f i + e mKIAA4195 960 -HFLI-LYVEP 968 P-ATPase-V: domain 1 of 1, from 3 to 990: score -474.6, E = 0.89 *->dktigisaYktspfkliiylvtlvltlgLvlLlltWkpewkvKltyv ++++++ + p ++ +++ ++ + l++ + l ++ mKIAA4195 3 RPRGREARPAGAP--AAMENAHTKTVE---EVLGHFGVNESTGLSLE 44 pvsnedaetvvivtpdevksWqlFevqvtvlsgsdeivelsnkslsndle v++ ++ + ++p + g + ++ + + mKIAA4195 45 QVKKLKERWGSNELP--------------AEEGKTLLELVIEQ------- 73 lenaveageepiyfdfrkqrfsyeekeqkqkRvLryFeyrsvkyifsplp f++ + r ++ l+ mKIAA4195 74 -------------FEDLLVRILL-------------------------LA 85 ylfkelsnLdfgdyskcagesnfGLttgeiakrkalYGkNeieipvpsfl ++++ + + + e mKIAA4195 86 ACISFV-----LAWFEEGEET----------------------------- 101 eLLkeEvlaPFYvFQvFSViLWllDEYyYYalcivfmsvlsivlsvyqir + +++PF i++++v+ v q r mKIAA4195 102 ---ITAFVEPF---------------------VILLILVANAIVGVWQER 127 kqlqeLrdmv.hkptqsVeViRn..ggQGYkwetiaSdeLVPGDivsipr +++ + + p ++ V+R +++ + i + ++VPGDiv+i mKIAA4195 128 NAENAIEALKeYEP-EMGKVYRQdrK----SVQRIKAKDIVPGDIVEIA- 171 ptqtGaeeklmPcDavL..LsGsCI.VNESmLTGESVPvlKvplpdesvd + +P+D L+++ ++ ++V+ S+LTGESV v K p mKIAA4195 172 ------VGDKVPADIRLtsIKSTTLrVDQSILTGESVSVIKHTDP----- 210 vegdddeklqlketskkHvLFgGTkvLQirpypgksdslkppdtgvlAiV +d + + +kk+ LF GT++ + g ++ +V mKIAA4195 211 --VPD---PRAVNQDKKNMLFSGTNI-----AAG----------KAMGVV 240 vRTGFsTsKGqLvRsiLYPkprvfkfykdsfkFilfLa.vlAliGfiYvi v TG +T G++ ++ + +++ + F L++v++li +++ i mKIAA4195 241 VATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSkVISLICIAVWI 290 ie...........likngsrskgkiiLrsLDIiTivVPPaLPaaLsvgin i+ ++ +++ ++++ +g ++ ++ i +L + +P +LPa ++ + + mKIAA4195 291 INighfndpvhggSWIRG-AIYYFKIAVALAV--AAIPEGLPAVITTCLA 337 naLaRLkkkgIFCisPfRInfAGkidvvCFDKTGTLTEDgLdlrGVqgls + +R +kk s + + G+ +v C DKTGTLT + + + +l mKIAA4195 338 LGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILD 387 gnqereikkvkLlkdiRqvFlkivtedsssldslvpsetvkalA...... ++ + +s + ++ ++t + +++ ++++ mKIAA4195 388 KVEG---------------------DTCSLNEFSITGSTYAPIGevqkdd 416 ...tCHsLtkleggkLvGDPLDlkmfeatgWtleedFqKRAFHSLYEGRe ++ CH+ l+ L + + + +l++ +YE + mKIAA4195 417 kpvKCHQYDGLVE-------LATICALCNDSALDY----NEAKGVYEKVG 455 eddesalptsilpaVvrPpkqLLPlsepNrelkltddppsqelsiirr.. e+ e+al + +v + L ls + +++ s+i++ mKIAA4195 456 EATETALTCLVEKMNVF-DTELKGLSKI--------ERANACNSVIKQlm 496 .....FeFsSaLqRMSVivstnderspdfklmafvKGAPEtIqslcsp.. +++ ++eFs ++MSV + n+ ++ fvKGAPE + +c + mKIAA4195 497 kkeftLEFSRDRKSMSVYCTPNKPSRTSM-SKMFVKGAPEGVIDRCTHir 545 ...etVP..sdyqevlksytre...Gy...RViAlAsKeLptkltlqkaq ++ VP ++ +++ + s +re ++G+++ R +AlA p mKIAA4195 546 vgsTKVPmtPGVKQKIMSVIREwgsGSdtlRCLALATHDNP--------- 586 dlsRdav...........EsnLtFlGfiVfenpLKpdTkeVIkeLkrAni l+R++ + +++ + + E nLtF+G + p + + + k + A i mKIAA4195 587 -LKREEMhledsanfikyETNLTFVGCVGMLDPPRIEVASSVKLCRQAGI 635 RtvMiTGDNlLTAvsVArecGivepsnvlilaeaeppesgkpaqikfevi R++MiTGDN TAv + r G ++++ mKIAA4195 636 RVIMITGDNKGTAVAICRRIG-IFGQ------------------------ 660 dsnsssdEviEDDAsvsismCsstWKGssEtqvipiastqveiPvklgkd d+ +v + mKIAA4195 661 DE-----------------------------------------DVTSK-- 667 SyledllasryhLAlsGkafavLqahsptdhiSFKPEWVKmQDKSVQKII A++G f L ++ mKIAA4195 668 -------------AFTGREFDELSPSAQ---------------------- 682 elllkLllhttVFARmaPdQKetlvelLqkldYtVgMCGDGANDCGALKq ++ +l+ + FAR+ P+ K +ve Lq d +++M GDG ND ALK mKIAA4195 683 ---RDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKK 729 ADVGISLseakepkklserrrreGmKmmYikdkeklsnsPlepvsktikq GI+ + +v kt+ mKIAA4195 730 SEIGIAMGSG-------------------------------TAVAKTASE 748 lfePGPKnPHYLKALessktkipPeerkateeeLqrkklakvlsdLenee L ++ mKIAA4195 749 -------------------------------------------MVLADD- 754 GDarsaPlvKLGeASvAAPFTSKlaSIsCVpnVIrEGRcaLvTSfqmFKy + s + EGR+ ++ mKIAA4195 755 -------------------------NFSTIVAAVEEGRA-------IYNN 772 maLysLiqfysvsiLYligsnlgDgQFltidLllG....ifvvallmSr. m + +i Yli+sn g + ++ +lG ++ + +v ll + mKIAA4195 773 MKQ---------FIRYLISSNVGEVVCIFLTAALGfpeaLIPVQLLWVNl 813 ...nkPlkkLskeRPpsnLfSv.......ylltSvliQfvlhilsqvylv +++ P+ L+ ++P+ + ++++++++++l++ l+ l i+ v+ mKIAA4195 814 vtdGLPATALGFNPPDLDIMNKpprnpkePLISGWLFFRYLAIGCYVGAA 863 felhkqpwykpeepk.DArnttG.GFWnsHvDnlvdlekenv.......p + + w++ ++ + F Dn++ ++++ + +++ + mKIAA4195 864 TVGAAAWWFIAADGGpRVSFYQLsHFLQCKEDNPDFDGVDCAifespypM 913 sleNTvlFfvSsfqYlitaivnskGpP...FreplykNkpfvysllGLIY ++ +vl + + + + ns ++ ++ r p ++N +v s+ mKIAA4195 914 TMALSVLVTIEMCN-----ALNSLSENqslLRMPPWENIWLVGSIC---- 954 tillaiillllldesphlgrilqivplp.qeFrskLlia<-* l++++ +l l+ +p l i+qi+pl +++ + L i mKIAA4195 955 --LSMSLHFLILYVEP-LPLIFQITPLNlTQWLMVLKIS 990 ATPase-IIA1_Ca: domain 1 of 1, from 70 to 1005: score 2035.6, E = 0 *->vleQFEDtLVRILLlAAvVSFvL.........vaalVEPfVILLILv v+eQFED+LVRILLlAA++SFvL ++++++++a+VEPfVILLILv mKIAA4195 70 VIEQFEDLLVRILLLAACISFVLawfeegeetITAFVEPFVILLILV 116 lNAiVGVWQErnAEkAIeALKeyesehalVlRdgr......eakDLVPGD +NAiVGVWQErnAE+AIeALKeye+e+++V+R++r++ ++ +akD+VPGD mKIAA4195 117 ANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRksvqriKAKDIVPGD 166 IVEiaVGdkVPADvRllelk..sLkvDQSiLTGEsvsVnKhtesVpkerA IVEiaVGdkVPAD+Rl+++k+++L+vDQSiLTGEsvsV+Kht++Vp++rA mKIAA4195 167 IVEIAVGDKVPADIRLTSIKstTLRVDQSILTGESVSVIKHTDPVPDPRA 216 vvQdKknMlFsGTlVvaGkArGVVvrTGmnTEIGkIrdevreaeqedTPL v+QdKknMlFsGT+++aGkA+GVVv+TG+nTEIGkIrde++++eqe+TPL mKIAA4195 217 VNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPL 266 kkKLDEFGelLsKvIgyICilVWViNighFn...........AiYYFKiA ++KLDEFGe+LsKvI++ICi+VW+iNighFn++ ++++ ++AiYYFKiA mKIAA4195 267 QQKLDEFGEQLSKVISLICIAVWIINIGHFNdpvhggswirgAIYYFKIA 316 VALAVAAIPEGLPAViTTCLALGtRKMAkkNAiVRkLPSVETLGCTTVIC VALAVAAIPEGLPAViTTCLALGtR+MAkkNAiVR+LPSVETLGCT+VIC mKIAA4195 317 VALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVIC 366 SDKTGTLTTNqMSVaklvale.........reFkVtGttYdPvggkikd. SDKTGTLTTNqMSV+++++l++ ++++ + +eF +tG+tY+P+g++ kd+ mKIAA4195 367 SDKTGTLTTNQMSVCRMFILDkvegdtcslNEFSITGSTYAPIGEVQKDd 416 ..........LeelAqiaALCNDSkLivdkkk..vekvGeaTEaALkVLv ++ + ++ ++L+elA+i+ALCNDS+L+++++k+ +ekvGeaTE+AL++Lv mKIAA4195 417 kpvkchqydgLVELATICALCNDSALDYNEAKgvYEKVGEATETALTCLV 466 EKiglpaakngkslksrpilgcnslw....kKkATLeFtRdRKSMSVlvk EK++++++++++++k++++++cns++++ kK++TLeF+RdRKSMSV+++ mKIAA4195 467 EKMNVFDTELKGLSKIERANACNSVIkqlmKKEFTLEFSRDRKSMSVYCT 516 ........snkLFvKGAPEevLercThIllkgsaVPLtekmkntiLasik ++++++++++k+FvKGAPE+v++rcThI++++++VP+t+++k++i+++i+ mKIAA4195 517 pnkpsrtsMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTPGVKQKIMSVIR 566 em..sseALRCLAlAfke...................ESkLtfiGvvGll e++++s++LRCLAlA+++++ ++++ + +++ + + E++Ltf+G+vG+l mKIAA4195 567 EWgsGSDTLRCLALATHDnplkreemhledsanfikyETNLTFVGCVGML 616 DPPRpEVadAiekCReAGIrVImITGDnKETAeAicRrIGils....... DPPR+EVa+++++CR+AGIrVImITGDnK+TA+AicRrIGi++++++ ++ mKIAA4195 617 DPPRIEVASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGIFGqdedvts 666 .SFTGrEFdemgpkk.......alvFSRvePsHKlrlVe.lqeqgqivAM ++FTGrEFde+ p+++++ +a++F+RvePsHK+++Ve lq++++i+AM mKIAA4195 667 kAFTGREFDELSPSAqrdaclnARCFARVEPSHKSKIVEfLQSFDEITAM 716 TGDGVNDAPALKkAdIGIAMGSGTeVAKeASdMVLADDNFATIVkAVeEG TGDGVNDAPALKk +IGIAMGSGT+VAK+AS+MVLADDNF+TIV+AVeEG mKIAA4195 717 TGDGVNDAPALKKSEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEG 766 RaIYNNmKqFIRYmISSNIGEVvsIFltsaLGi.eglipvQLLWVNLVTD RaIYNNmKqFIRY+ISSN+GEVv+IFlt+aLG++e+lipvQLLWVNLVTD mKIAA4195 767 RAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFpEALIPVQLLWVNLVTD 816 GLPATALgFNpPDkDiMkkpPRredeSPLitgWlFfRYLViGvYVGlATV GLPATALgFNpPD+DiM+kpPR+++e PLi+gWlFfRYL+iG+YVG+ATV mKIAA4195 817 GLPATALGFNPPDLDIMNKPPRNPKE-PLISGWLFFRYLAIGCYVGAATV 865 igfiWw......................................KqkasT ++++Ww +++++ + + ++ + ++++++ ++ + ++++++ T mKIAA4195 866 GAAAWWfiaadggprvsfyqlshflqckednpdfdgvdcaifesPYPM-T 914 lSLSVLVviEMfNALNALSEDsSLLripPweNkWLigAIcvSmaLHflIL ++LSVLV+iEM+NALN+LSE++SLLr+pPweN+WL+g+Ic+Sm+LHflIL mKIAA4195 915 MALSVLVTIEMCNALNSLSENQSLLRMPPWENIWLVGSICLSMSLHFLIL 964 YVpllsaiFgvtPLsltdWlmvLkvSlPViLvDEvLKlfSR<-* YV++l++iF++tPL+lt+WlmvLk+SlPViL+DE+LK+++R mKIAA4195 965 YVEPLPLIFQITPLNLTQWLMVLKISLPVILMDETLKFVAR 1005 ATPase-IIA2_Ca: domain 1 of 1, from 19 to 1008: score 361.0, E = 1.2e-104 *->SvqYcelsVeEtcskLqTDlenGLsSsqEashRRklHGsNefkvEed + + +VeE++ + +GLs + + + ++ GsNe+ Ee mKIAA4195 19 -ENAHTKTVEEVLGHFGVNESTGLS-LEQVKKLKERWGSNELPAEEG 63 EsLvKKFlsQFvkdPLILLLiaSAvvSvfMGNiDDA.vSIT......LAI L ++QF +d L+ L+ +A +S+ + + + IT ++ + mKIAA4195 64 KTLLELVIEQF-EDLLVRILLLAACISFVLAWFEEGeETITafvepfVIL 112 lIVVT...VGFVQEYRSEKSLEALNKLVPpECHliRaGke..eHvLAStL lI V + VG QE E EAL P + R + + + + A + mKIAA4195 113 LILVAnaiVGVWQERNAENAIEALKEYEPEMGKVYRQDRKsvQRIKAKDI 162 VPGDLVilsvGDRvPADlRI..vEAvdLSIDESNLTGEttPvkKssepie VPGD V+ vGD vPAD+R+++++ + L +D S LTGE v K + p++ mKIAA4195 163 VPGDIVEIAVGDKVPADIRLtsIKSTTLRVDQSILTGESVSVIKHTDPVP 212 ...aLa.eRsNIAfMGTLVReGhGkGIVVGTGsnTeFGaVFkMmqeiEkP +++a ++ N f GT + G++ G+VV+TG nTe G++ + m ++E mKIAA4195 213 dprAVNqDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQE 262 KTPLQkSMDkLGKdLS.LvSFivIGv.IcLVGif....QGkdWLE....M TPLQ+ D+ G +LS+ +S+i I+v I+ +G f+++ G +W + mKIAA4195 263 RTPLQQKLDEFGEQLSkVISLICIAVwIINIGHFndpvHGGSWIRgaiyY 312 FTIsVSLAVAAIPEGLPIIVTVTLALGVLRMsKkrAIVRkLPSVETLGSV F I V LAVAAIPEGLP ++T LALG RM+Kk AIVR LPSVETLG+ mKIAA4195 313 FKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCT 362 NVICSDKTGTLTkNHMTVTkiwTvDelna..vsLdtvave.......... VICSDKTGTLT N M+V + + +D++ +++ sL+ ++ +++ + ++ mKIAA4195 363 SVICSDKTGTLTTNQMSVCRMFILDKVEGdtCSLNEFSITgstyapigev 412 ................kiLeaGnLCNNakfr.neadtl...lGnPTDvAL ++++++ + ++ ++ + ++ +LCN++ nea +++G +T+ AL mKIAA4195 413 qkddkpvkchqydglvELATICALCNDSALDyNEAKGVyekVGEATETAL 462 IEllekF.....GLeD.............lReTykRvaEvPFSSeRKwMa l ek++ +++L++ ++ ++ + ++ +++ k+ + FS RK M+ mKIAA4195 463 TCLVEKMnvfdtELKGlskieranacnsvIKQLMKKEFTLEFSRDRKSMS 512 vkvvtd...skem..vfvKGAyEqvlkyCtyYlkkdGkKTeeLTeeqkek v ++ ++++++ m++ fvKGA E v+ Ct k ++T k k mKIAA4195 513 VYCTPNkpsRTSMskMFVKGAPEGVIDRCTHIRVGSTK--VPMTPGVKQK 560 iqeeaaeM..aseGLRviAfAs...................gtekdLvFl i e +++s+ LR +A+A ++++ ++++ + +++ + + e++L+F mKIAA4195 561 IMSVIREWgsGSDTLRCLALAThdnplkreemhledsanfiKYETNLTFV 610 GLvGinDPPRPdVkeAverLltGGVrviMITGDSeeTAvsIArrlGmpvk G vG+ DPPR +V +v+ + G+rviMITGD TAv+I rr+G+ mKIAA4195 611 GCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGIFGQ 660 ssk......eGekLDeMddqqLsevvdkVavFARasPeHKMKIVkaLQkr + + +++ G + De++ ++ +++ + FAR P HK KIV+ LQ+ mKIAA4195 661 DEDvtskafTGREFDELSPSAQRDACLNARCFARVEPSHKSKIVEFLQSF 710 GDVVAMTGDGVNDAPALKLADIGvAMGrtGTDVAKEAADMILTDDDFaTI + AMTGDGVNDAPALK + IG+AMG GT VAK A+ M+L DD F+TI mKIAA4195 711 DEITAMTGDGVNDAPALKKSEIGIAMG-SGTAVAKTASEMVLADDNFSTI 759 LSAIEEGKGIFNNIkNFiTFQLSTSvAALSLvAlaTvfglpNPLNAMQIL A+EEG I+NN k Fi+ S v + l ++g+p L + Q L mKIAA4195 760 VAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLL 809 WINILMDGPPAQSLGVEPVDkDVmkKPPRpRndkIlTkdLlkkvLvsAvI W+N DG PA LG P D D+m+KPPR+ +++ ++ L + L mKIAA4195 810 WVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCY 859 IvvGTl......lV..............FvkeMqEDG.vvTaRDT..... + T++ ++ +++++ + + + + +ED++ + D ++ mKIAA4195 860 VGAATVgaaawwFIaadggprvsfyqlsHFLQCKEDNpDFDGVDCaifes 909 ....TMTFTCFVFFDMFNALACRSeTKSVFEIGfFSNrMFnYAVGgSliG + + TM V M NAL + Se S + N + +S+ mKIAA4195 910 pypmTMALSVLVTIEMCNALNSLSENQSLLRMPPWENIWLVGSICLSMSL 959 QllVvYvPplQsvFQTEaLsikDlLlLLlitSSVlIVDEirKlyeRske< l+ Yv pl +FQ L + L+ L i+ V DE K++ R mKIAA4195 960 HFLILYVEPLPLIFQITPLNLTQWLMVLKISLPVILMDETLKFVARNYL 1008 -* mKIAA4195 - - ATPase-IID_K-Na: domain 1 of 1, from 16 to 1013: score 96.7, E = 4.6e-25 *->NiefnvYfslikdveaEFlGTSlteGLTqdEavnRLke.vGENrLed + n+ ++ + ++ G GL E v Lke+ G N L + mKIAA4195 16 AAMENA-HTKTVEEVLGHFGVNESTGLSL-EQVKKLKErWGSNELPA 60 DskvdakkvlLrQVlNAMivVLllaailSFattDWIeGG........... + ++ Q ++ +Lllaa +SF W e G+++ + ++ mKIAA4195 61 EEGKTLLELVIEQFEDLLVRILLLAACISFVLA-WFEEGeetitafvepf 109 VISavIvlNvlvGlvQEYKAeKTMdSLktLaSPnAHViRssK..sdaIdS VI + v N +vG QE Ae + Lk + V R +++ I mKIAA4195 110 VILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRksVQRIKA 159 kllVPGDvvllKvGDvvPADLRL..vETkNFdTDEaLLTGESLPViK... k++VPGD+v + vGD vPAD RL+++ D + LTGES ViK+++ mKIAA4195 160 KDIVPGDIVEIAVGDKVPADIRLtsIKSTTLRVDQSILTGESVSVIKhtd 209 ...DAnlvFqkeEdvsvGDRlNLAySSSiVvKGRAKGIvikTalnseIGk + +D +v q D N+ +S + G A G+v++T+ n+eIGk mKIAA4195 210 pvpDPRAVNQ--------DKKNMLFSGTNIAAGKAMGVVVATGVNTEIGK 251 IAksLrqdskLisRdPskrrklNkyilKvTkkvvqavLGlNVGTPLqRKL I Rd + + TPLq KL mKIAA4195 252 I------------RDEMVATEQER-------------------TPLQQKL 270 skLA.....vl.LFcIAvllAIIVMAaqkFdVdkrV..aIY....AIsla ++ ++v++L cIAv + I + +++aIY + A++la mKIAA4195 271 DEFGeqlskVIsLICIAVWIINIGHFNDPVHGGSWIrgAIYyfkiAVALA 320 lSiIPeSLvvVLsITMavGakvMvkRrVIVRKLdaLEALGaVtDICSDKT + IPe L +V + +a+G + M k + IVR L + E LG ICSDKT mKIAA4195 321 VAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKT 370 GTlTQGKMlaRrvWIPryGylsvdtSDDafNPtiG.tVSllEdadvdvLk GTlT M r I d +G+t Sl E + mKIAA4195 371 GTLTTNQMSVCRMFI-------LDKV-------EGdTCSLNEFSITGSTY 406 ekKdrlkekDLPedi.dsDlFiklLkTaaLaNlaTVfKddeTdeWkvkGd + D P + D + l +aL+N + +++ + G+ mKIAA4195 407 APIGEVQKDDKPVKChQYDGLVELATICALCNDSALDYNEAKGVYEKVGE 456 PTEIAlqVFakkfdlGkkdl.........lksNefv.....aEyP..FDS TE Al k++ +l++ ++ ++ + N +++ ++E+ +F mKIAA4195 457 ATETALTCLVEKMNVFDTELkglskieraNACNSVIkqlmkKEFTleFSR 506 evKRMavvYednq...netYtvYaKGAvErIlerCSssyGstLedpDvEl + K M+v n++++ + KGA E +++rC p mKIAA4195 507 DRKSMSVYCTPNKpsrTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTPG 556 IiknvesLaaE......GLRVLalAsKv..idKddvni..TlnRdvAESd + ++ s E +++++ LR LalA+ +++ +++ ++ n E mKIAA4195 557 VKQKIMSVIREwgsgsdTLRCLALATHDnpLKREEMHLedSANFIKYETN 606 LvFlsLvGIYDPPRtEskGAVkkfHrAGIrVHMLTGDfveTAKAIArEVG L F++ vG DPPR E + Vk++ +AGIrV M TGD +TA AI r +G mKIAA4195 607 LTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGTAVAICRRIG 656 IlPtnlisdrdeivdsMVMTGSQFDaLSdEEVDdLkvLpLVIARCaPQTK I de v s TG FD LS d AR P K mKIAA4195 657 IFGQ------DEDVTSKAFTGREFDELSPSAQRDACLNARCFARVEPSHK 700 VkMIEALHRRKkFvaMTGDGVNDSPSLKqANVGIAMGiNGSDVaKdASDI k +E L aMTGDGVND P LK +GIAMG G VaK AS mKIAA4195 701 SKIVEFLQSFDEITAMTGDGVNDAPALKKSEIGIAMGS-GTAVAKTASEM 749 VLsDDNFaSIlNAvEEGRRMfDNIqkFVLqLLveNVaev..llLvvGLvF VL DDNF+ I+ AvEEGR + N +F+ L +NV+ev ++L L F mKIAA4195 750 VLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVvcIFLTAALGF 799 RDEvgkSVFPlSPVEvLWiivvTSsFPaMGLGlEkAaPDlMdRlPHDskV l PV LW+++vT Pa LG D+M+ +P k mKIAA4195 800 PEA-------LIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRNPKE 842 GIFtkelIvDtfvYGiiltvvslasfvvilYGinsG.rLsyDCdatYnas l ++ G + G+r s+ ++ mKIAA4195 843 PLISGWLFFRYLAIGCYVGAATVGAAAWWFIAADGGpRVSFYQLSHFL-Q 891 Cr....DVykaRSAvF.....AvvTfCiLIlAvEVkdfdrSlFrlHGiPd C+++++D A+F+++ + ++ +L+ +E + +Sl mKIAA4195 892 CKednpDFDGVDCAIFespypMTMALSVLV-TIEMCNALNSL-------- 932 tdsnvkeFlrs.lveNkFLaWaIilaaVSvFPvvYI...PVINddVFkHk s + lr + +eN L +I l F + Y+++ P I F + mKIAA4195 933 --SENQSLLRMpPWENIWLVGSICLSMSLHFLILYVeplPLI----FQIT 976 yIGa.EWGlvivaviayfiyvElyKsikRrlf.ktQk<-* + + W +v + + E K + R + +++ k mKIAA4195 977 PLNLtQWLMVLKISLPVILMDETLKFVARNYLeQPGK 1013 ATPase-Plipid: domain 1 of 1, from 72 to 1018: score -710.0, E = 0.0034 *->FpsNkIsTtKYtvlTFlPKnLFeQFkrfANiYFLvvAllqqvPilsp eQF L A++++v l+ mKIAA4195 72 ----------------------EQFEDLLVRILLLAACISFV--LAW 94 t....nrgtsivPLavVLlvtaiKeAiEDirRrkrDkevNNrltevLegv +++++ +t +v v+Ll+ + ++ ++ r++ +++ e L + mKIAA4195 95 FeegeETITAFVEPFVILLILVANAIVGVWQERNAENAI-----EALKE- 138 eNeNvltdnIsLWRklKKFIsytkedlsee...lKkkrisRKRHellvtk +e++ +K r mKIAA4195 139 ----------------------------YEpemGKVYRQD---------- 150 TVdtishRsSLdSidayrlSvdydrleldeinleqganeasvvdrsltgs + mKIAA4195 151 -------------------------------------------------R 151 sdgkFveikWKdlrVGDIvKVkkderiPADllLLSSSepdGvCYVETaNL +ik Kd++ GDIv + ++ +PAD+ L +S + mKIAA4195 152 --KSVQRIKAKDIVPGDIVEIAVGDKVPADIRL--TSIKS---------- 187 DGETNLKlRqAleeTqkmlteediknfsGeIecEqPnasLYsFqGnlkid T L + q++ +T ++ +ik + + +P a + d mKIAA4195 188 ---TTLRVDQSI-LTG--ESVSVIKHTD---PVPDPRA--------VNQD 220 gkakskIrqlPLspdNiLLRGctLrNTkwviGvVvYTGhDTKl..mrNat + N+L G+ + + ++GvVv TG T +++ r + mKIAA4195 221 K-------------KNMLFSGTNIAA-GKAMGVVVATGVNTEIgkIRDEM 256 kaGPsKRSriEkelN....flIiiLFllLivLclissvgagiysdadgkd a R+ + +l++ +++l+++++l+ i+ +i + + + +g+ mKIAA4195 257 VATEQERTPLQQKLDefgeQLSKVISLICIAVWIINI--GHFNDPVHGG- 303 ldlirwYleldkseRPGGkdYeYrnaaangFfsfltalILFssLIPISLY +w ++ +++ f a+ L IP L mKIAA4195 304 ----SWIRG--------------------AIYYFKIAVALAVAAIPEGLP 329 VslElvKsvQAtyFInsDlemYhektDtPasvRtSNLnEeLGQVeYiFSD ++ + A + + m +k + a+vR++ +E LG i SD mKIAA4195 330 A---VITTCLA----LGTRRM--AKKN--AIVRSLPSVETLGCTSVICSD 368 KTGTLTqNiMeFkKcsIaGvsYgSdgltevkdalrerkgskveeesakva KTGTLT N M+ +c + + d+++ ++++l e s + + mKIAA4195 369 KTGTLTTNQMS--VCRM---FIL-DKVEGDTCSLNEF--SITGST----- 405 kDknsmlnelkilksnsqkapkgftFvdprLvkllktaknkpnakliqeF + + e++ +++ + + + e+ mKIAA4195 406 ---YAPIGEVQ--------------------KDDKPV--KCHQYDGLVEL 430 flaLAiCHtVvPevnddddpeKGeitYQAaSPDEaAL........VkaAr + A+C+ + n+ ++ e++ +A E AL+ ++ +V ++ mKIAA4195 431 ATICALCNDSALDYNE-AKGVY-EKVGEAT---ETALtclvekmnVFDTE 475 dlGFvfieRtpksIsllieerGkkGkkeekeYeiLnVlEFnSdRKRMSvI G++ ieR + s +i + k ke+ lEF+ dRK MSv mKIAA4195 476 LKGLSKIERANACNS-VIKQLM-K-----KEFT----LEFSRDRKSMSVY 514 vRfPdgnPGDdgrilLlcKGA.....DsVifkRLssssGsggnqvieeTk + + P + ++KGA+++ D R+ s +v + + mKIAA4195 515 CTPN--KPSRTSMSKMFVKGApegviDRCTHIRVGSTKVPMTPGVKQKIM 562 eHLeny..AsEGLRTLciAyReLseeEYeeWneeYneAstaLtedReekL + +++s+ LR L +A + L+ ++e L mKIAA4195 563 SVIREWgsGSDTLRCLALATHD-----------------NPLK-REEMHL 594 devAelI..EkdLiLLGaTAIEDKLQeGVPetIElLreAGIKiWVLTGDK + A+ I+ E++L +G + D V ++ l r+AGI++ + TGD mKIAA4195 595 EDSANFIkyETNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDN 644 vETAINIGySCrLlsenMelivIkeesddIrelEdagdldatervveaai TA I Cr ++ ++ + d +++ a mKIAA4195 645 KGTAVAI---CR------RIGIFGQDED----------VTS------KAF 669 kkiLkeyfelegteeefnelkkdhvpsgnvALvIDGksLkyaLdeeDlek + + ef el+ + ++++L + mKIAA4195 670 T------------GREFDELSP--SAQRDACL------------NA---- 689 eFLqLAlkCkAViCCRVSPsQKAdVVkLVKkstGrlskiTLAIGDGANDV +C A RV Ps K+ +V + + iT GDG ND mKIAA4195 690 -------RCFA----RVEPSHKSKIVEFLQS----FDEITAMTGDGVNDA 724 SMIQeADVGVGIsGkEGmQAvMASDFAIgQFrFLekLLLVH......... + +G+ +M S A + + + +L ++ ++ mKIAA4195 725 PALKKSEIGI----------AMGSGTAVA--KTASEMVLADdnfstivaa 762 ...GrWSYkRiskmIlYfFYKNlifalilFWYsfyngFsGqtlyedWymv ++Gr Y+ + + I Y N+ + + F +++ gF + +l+ ++ mKIAA4195 763 veeGRAIYNNMKQFIRYLISSNVGEVVCIFL-TAALGF-PEALIPVQLLW 810 lYNvfFTalPVivLGvfDqDvsaslslryPqLYreGqkgkefstkvFwgw N++ lP +LG D++ ++ + P + k s+ +F+ + mKIAA4195 811 V-NLVTDGLPATALGFNPPDLD--IMNKPP----RNPKEPLISGWLFFRY 853 mldglyQSlviFffpilayklgdfvssG..evddfssvGvivfT...... +g y +++ + +a ++ ++ +G++ v+ f+ ++ + ++++++ mKIAA4195 854 LAIGCYVGAATVGA--AAWWFIAA--DGgpRVS-FYQLSHFLQCkednpd 898 .....alVv......vvnlkiaLeinrWnwisliaiwgSiL.......vw ++ ++++++++ + + l ++ +i+ n +++ S+L+ ++ +++w mKIAA4195 899 fdgvdCAIFespypmTMALSVLVTIEMCNALNSLSENQSLLrmppwenIW 948 li..........fvivyssifptlPadisrefykaakrvms.tfgFWlvL l+++ + + +f+i y + +p ++++ + + Wl + mKIAA4195 949 LVgsiclsmslhFLILYVEPLP------------LIFQITPlNLTQWLMV 986 lvivlisLLPrFtykalqr.lfrPtdyeiVqE<-* l i l +L + t+k++ r++++ + e Vq mKIAA4195 987 LKISLPVILMDETLKFVARnYLEQPGKECVQP 1018 ATPase-IIC_X-K: domain 1 of 1, from 6 to 1021: score 329.7, E = 3.4e-95 *->kkkekleelkkElelddHklsleelerkyqtdlekGLsearaaelLa ++++ +e + H +ee+ +++++ + GLs +++++l + mKIAA4195 6 GREARPAGAPAAME-NAHTKTVEEVLGHFGVNESTGLSLEQVKKLKE 51 RDGpnaLtPPkqtPEwvKFcrqlfGGfsiLlWigailCflAygiqaseee R G n L P ++ + + + f +L+ i + + + + ee mKIAA4195 52 RWGSNEL-PAEEGKTLLELVIEQFE--DLLVRILLLAACISFVLAWFEEG 98 epsddnlYLgivLsavvivtGvFsYYqEaKsskimesFknmvPqqAlviR e + v+ ++ + + + +qE + + +e+ k+ P v R mKIAA4195 99 EETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYR 148 dgeK..lsinaeqlvvGdlvevkgGDriPadlRi..isakgckvDnssLt + K+ i+a ++v Gd+ve+ GD++Pad+R+++i++ ++vD s Lt mKIAA4195 149 QDRKsvQRIKAKDIVPGDIVEIAVGDKVPADIRLtsIKSTTLRVDQSILT 198 GEsEPqtRspeft...henPlEtkniaffstncvegtakGivvstGDrtv GEs + ++ +++ + kn+ f tn g a G+vv+tG +t mKIAA4195 199 GESVSVIKHTDPVpdpRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTE 248 iGriAsLAsGlengktPiAiEieHFihiitGvAvflGvsFfiial..... iG+i e+++tP+ ++ F + ++ v ++ ++ +ii +++ ++ mKIAA4195 249 IGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIAVWIINIghfnd 298 .ilgYtwLeaviFl....igiivAnvPEGLLAtvtvcLtltAKrmAkKnC ++ g +w++ i+ + +++ vA +PEGL A +t cL+l +rmAkKn mKIAA4195 299 pVHGGSWIRGAIYYfkiaVALAVAAIPEGLPAVITTCLALGTRRMAKKNA 348 lvKnLEAvetLGstsviCsDKtGtLtqnrmtvahlWfDnqi......... +v+ L vetLG tsviCsDKtGtLt n+m v ++ +++++++ + ++ mKIAA4195 349 IVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDKVegdtcslne 398 ..heADttEdqsgvsfD......kssetwkaLsriatLCnRAeFkagqdn +++ t v+ D+++ + ++ + L+ i +LCn + + ++ mKIAA4195 399 fsITGSTYAPIGEVQKDdkpvkcHQYDGLVELATICALCNDSALDYN-EA 447 vpvlkkevaGDAsEtAlLKfiE..............lslGdvme..iRer v k +G+A EtAl ++E+ + +++ ++ +++ ++ ++ i++ mKIAA4195 448 KGVYEK--VGEATETALTCLVEkmnvfdtelkglskIERANACNsvIKQL 495 nkKvaEiPFnstnKyqlsiHetedpsdkryl..lvmKGAPEriLerCsti kK + F s + +s+ t + + ++++ +KGAPE +++rC i mKIAA4195 496 MKKEFTLEF-SRDRKSMSVYCTPNKPSRTSMskMFVKGAPEGVIDRCTHI 544 likGkeqpLdeelkeafqnAYleLGGLGERvLGFchlyLpedqyPegfkF + + p+ +k+ e G G L l+ ++ + mKIAA4195 545 RVGSTKVPMTPGVKQKIMSVIREWGS-GSDTLRCLALATHDNPLKREEMH 593 dvdevnFpt..enLcFvGLlsmidPPRaavPDAvaKCRsAGikvimvtGD d nF + nL FvG + m+dPPR v v CR AGi+vim+tGD mKIAA4195 594 LEDSANFIKyeTNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGD 643 HPitAKAiAksvGiisegnEtvEDiAaRLnipveqvnkrdAkAcvvhGae tA Ai + +Gi ++ ED+ + +G e mKIAA4195 644 NKGTAVAICRRIGIFGQD----EDVTSK----------------AFTGRE 673 LkDmsseqldeiLknhtEivFARtsPqqKLiivEgCqRqgAivAvtGDGv ++s++ ++ n FAR P K ivE q + i A+tGDGv mKIAA4195 674 FDELSPSAQRDACLNAR--CFARVEPSHKSKIVEFLQSFDEITAMTGDGV 721 nDsPAlKKADiGvAmGiaGsDvsKqAADmiLLDDnFAsivtGvEeGRLiF nD+PAlKK +iG+AmG +G v+K A +m+L DDnF iv vEeGR i+ mKIAA4195 722 NDAPALKKSEIGIAMG-SGTAVAKTASEMVLADDNFSTIVAAVEEGRAIY 770 DnLKKsiaYtLtsnipEitPfLifiivniPLPlGtitiLcidLgtDivPa n+K+ i Y + sn+ E+ + ++ P l + +L ++L tD +Pa mKIAA4195 771 NNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLLWVNLVTDGLPA 820 isLAYekAEsDimkrkPrnpkrDkLvnerLislaYgqiGmi..qalagFf +L ++ + Dim++ Prnp ++ L+ L + Y+ iG + a+ g + mKIAA4195 821 TALGFNPPDLDIMNKPPRNP-KEPLISGWLF-FRYLAIGCYvgAATVGAA 868 tYFvilAenGflPskllglRveWddkavndleDsyGqeWtyeqRkvleyt ++ i A+ G P+ + ++ + +d D G + ++ + t mKIAA4195 869 AWWFIAADGG--PRVSF-YQLSHFLQCKEDNPDFDGVDCAIFESPY-PMT 914 cytaFFvsivvvqwADliirKtRRnsvFqqGlmrnkilifglveetalaa v+i+++ + +s+ +n l+ ++ + l mKIAA4195 915 MALSVLVTIEMCNALNSL---SENQSLLRMPPWENIWLVGSICLSMSLHF 961 fLsYcpGmetalrlyplkltwWlvalPysllifvYDEiRklilRrn...P ++ Y ++ +++++pl+lt Wl+ l sl + + DE+ k++ R + ++P mKIAA4195 962 LILYVEPLPLIFQITPLNLTQWLMVLKISLPVILMDETLKFVARNYleqP 1011 GgWveketYY<-* G + mKIAA4195 1012 GKECVQPATK 1021 //