hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mbg/mbg07034/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA4184  ( 905 res)   mbg07034

Scores for sequence family classification (score includes all domains):
Model        Description                                Score    E-value  N 
--------     -----------                                -----    ------- ---
Lig_chan     Ligand-gated ion channel                   547.4   9.6e-161   1
ANF_receptor Receptor family ligand binding region      185.4    9.3e-52   1
SBP_bac_3    Bacterial extracellular solute-binding p   -61.4     0.0034   1

Parsed for domains:
Model        Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
--------     ------- ----- -----    ----- -----      -----  -------
ANF_receptor   1/1      57   401 ..     1   423 []   185.4  9.3e-52
SBP_bac_3      1/1     436   813 ..     1   258 []   -61.4   0.0034
Lig_chan       1/1     563   856 ..     1   307 []   547.4 9.6e-161

Alignments of top-scoring domains:
ANF_receptor: domain 1 of 1, from 57 to 401: score 185.4, E = 9.3e-52
                   *->qvlpAmelAieeiNadggillpgitlgyedddtcsksyalcsslsfd
                      q   A+++A++  N + +   ++++l+y++d  +s            
   mKIAA4184    57    QEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLDS-----------S 92   

                   p.aavaaaacllkskgVvaiiGPscssvaiavarlanefgiPlisygats
                   +++ v++a c++ s+gV+ai+G++  ++  ++++++++++  ++++    
   mKIAA4184    93 NsFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTP---- 138  

                   pslsdksktryptffRtvpsdtkqgaAiadilkhtfgWkrvaviyddddy
                    s++   +   ++++   p     +  ++ +    ++W +++ +yd + +
   mKIAA4184   139 -SFPT--DADVQFVIQMRPALKGAILSLLGY----YKWEKFVYLYDTERG 181  

                   dygeggcYFtlealeealkeaggkvvavAqasdvvvvseviagdddftal
                              ++l++++++a  ++++v        +++ + + +d++++
   mKIAA4184   182 ----------FSILQAIMEAAVQNNWQV--------TARSVGNIKDIQEF 213  

                   lkelkdlikskarvvvvcgssddlgllkrqilrqarelGlmsggyvwilt
                    +++ ++ +++++ ++++++ +++      il+q++ lG  s gy++ l+
   mKIAA4184   214 RRIIEEMDRRQEKRYLIDCEVERI----NTILEQVVILGKHSRGYHYMLA 259  

                   dlwstsldsqgdgsdlpwariagadeGlltartfppqldndkareaakgv
                   +l +t+                               +  ++ ++ ++++
   mKIAA4184   260 NLGFTD-------------------------------IVLERVMHGGANI 278  

                   lgftlk.p.spefqeflerlkk.........ldtevnsyallaYDAVyll
                   +gf++++ ++p++q+f +r+ + ++++ ++ +++ + ++++l++DA++++
   mKIAA4184   279 TGFQIVnNeNPMVQQFIQRWVRlderefpeaKNAPLKYISALTHDAILVI 328  

                   AhAlnetlsddpngtasgcnacrdsrvddasnalg.gnlnlg.lkkw.dG
                   A+A++ +++++ +++++g                + g+++++++ +w++G
   mKIAA4184   329 AEAFRYLRRQRVDVSRRG----------------SaGDCLANpAVPWsQG 362  

                   sqlleylrnkvnFeGltGpvqfddnggrrpdyslvilnwdg<-*
                    ++ ++l++ v+ +G+tG++qfd  +grr++y+++++ ++    
   mKIAA4184   363 IDIERALKM-VQVQGMTGNIQFDT-YGRRTNYTIDVYEMKV    401  

SBP_bac_3: domain 1 of 1, from 436 to 813: score -61.4, E = 0.0034
                   *->LrVGtegtypPFefkded..d.sGk..lvGFDvDlakAiakklk.gv
                      ++V t     P+ ++ +++++ +G++++ G+ vDla +iak  +  +
   mKIAA4184   436    IVVTTILE-SPYVMYKKNheQlEGNerYEGYCVDLAYEIAKHVRiKY 481  

                   Kvefv...........ptdwdglipaLqsgkvDviiagmtiTpeRkkkvd
                   K+ +v++++ + ++++   w+g+   L  g++D+++a +tiT  R++++d
   mKIAA4184   482 KLSIVgdgkygardpeTKIWNGMVGELVYGRADIAVAPLTITLVREEVID 531  

                   FFSdPYytsgavlvtvkkdnelg...........................
                   F S P++  g+ +   kk  +++++  +  ++   +          + + 
   mKIAA4184   532 F-SKPFMSLGISIM-IKKPQKSKpgvfsfldplayeiwmcivfayigvsv 579  

                   ..................................................
                        ++ ++ + + +++++++++++++++++++ +  ++   + +   +
   mKIAA4184   580 vlflvsrfspyewhlednneeprdpqsppdppnefgifnslwfslgafmq 629  

                   ..........................................dlnsgaav
                   ++ + ++++ +++  ++     +    ++ + +     + ++ +++    
   mKIAA4184   630 qgcdisprslsgrivggvwwfftliiissytanlaafltverMVSP---- 675  

                   saiksleDLkGkkaKkvgvqlGtty.ed............gekllkkyga
                     i s eDL++     + ++ Gt  + ++++  ++++    ek+   ++ 
   mKIAA4184   676 --IESAEDLAK----QTEIAYGTLDsGStkeffrrskiavYEKMWSYMKS 719  

                   kkgdkaevvtyddqp.ealqdLknGRiDAvlnDrlvllyyaayllkkpdg
                        ae   +++++ + +  ++  +  +++  + + ++   y+ + ++ 
   mKIAA4184   720 -----AEPSVFTKTTaDGVARVRKSKGKFAFLLESTMNE---YIEQRKPC 761  

                   akplkivgdplsdpkefgegygiavrKgkddkeLkdklNkALkelkadGt
                     +   vg  l+       gyg+a  Kg    +L   +N A  +l + G 
   mKIAA4184   762 --DTMKVGGNLDS-----KGYGVATPKG---SALGTPVNLAVLKLSEQGI 801  

                   lkkIseKw.Fgt<-*
                   l+k+ +Kw +++   
   mKIAA4184   802 LDKLKNKWwYDK    813  

Lig_chan: domain 1 of 1, from 563 to 856: score 547.4, E = 9.6e-161
                   *->slevWlcilaayllvsvvlwlverwfsPyewrgnrqprpcaeddeaP
                        e+W+ci++ay++vsvvl+lv+r fsPyew+ +  ++++ +d   P
   mKIAA4184   563    AYEIWMCIVFAYIGVSVVLFLVSR-FSPYEWHLED-NNEEPRD---P 604  

                   qspeeepnqftlsnslWFsfgalmqQGcdelPrslSgRivvgvWwfFaLi
                   qsp+  pn+f ++nslWFs+ga+mqQGcd++PrslSgRiv+gvWwfF+Li
   mKIAA4184   605 QSPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLI 654  

                   lisSYTANLAAFLTvermqspIesleDLakqnpkieYGtlrggstftffk
                   +isSYTANLAAFLTverm+spIes+eDLakq+ +i YGtl++gst++ff+
   mKIAA4184   655 IISSYTANLAAFLTVERMVSPIESAEDLAKQT-EIAYGTLDSGSTKEFFR 703  

                   eskiptyrrmweymnsrkgrskaPsvfvksyeeGvqrVrkgpenglyAfl
                   +ski++y +mw+ym+s+      Psvf+k++++Gv+rVrk+  +g++Afl
   mKIAA4184   704 RSKIAVYEKMWSYMKSAE-----PSVFTKTTADGVARVRKS--KGKFAFL 746  

                   mEstyleyevarnpdCdLttvGevlfgtkGYGIAlpkgSPlrdklslAIL
                   +Est++ey+ +r+p Cd+++vG+ ++++kGYG+A+pkgS l   ++lA+L
   mKIAA4184   747 LESTMNEYIEQRKP-CDTMKVGG-NLDSKGYGVATPKGSALGTPVNLAVL 794  

                   eLsEsGelekLenKWwkkkgkCpsesta..vsssqLglenfaGlFliLgi
                   +LsE+G l+kL+nKWw++kg+C  +++ +++++s+L+l+n+aG+F+iL +
   mKIAA4184   795 KLSEQGILDKLKNKWWYDKGECGAKDSGskDKTSALSLSNVAGVFYILVG 844  

                   GlvlallvalfE<-*
                   Gl+la++val+E   
   mKIAA4184   845 GLGLAMMVALIE    856  

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