hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mbh/mbh04331/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA4160  ( 676 res)   mbh04331

Scores for sequence family classification (score includes all domains):
Model      Description                                  Score    E-value  N 
--------   -----------                                  -----    ------- ---
WWE        WWE domain                                   242.4    6.5e-69   2
zf-C3HC4   Zinc finger, C3HC4 type (RING finger)         22.5     0.0047   1
Extensin_2 Extensin-like region                        -136.7       0.38   1

Parsed for domains:
Model      Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
--------   ------- ----- -----    ----- -----      -----  -------
WWE          1/2      64   143 ..     1    89 []   124.9  1.5e-33
WWE          2/2     144   220 ..     1    89 []   120.1  4.1e-32
zf-C3HC4     1/1     467   527 ..     1    50 []    22.5   0.0047
Extensin_2   1/1     256   543 ..     1   385 []  -136.7     0.38

Alignments of top-scoring domains:
WWE: domain 1 of 2, from 64 to 143: score 124.9, E = 1.5e-33
                   *->svappsnvagikvvvWeyerSvddnggWrpYsphvsrlIEnayaakk
                      +++pp+nva+  vvvWe+    +++ +WrpY   v+++IEn+++++ 
   mKIAA4160    64    LGFPPQNVAR--VVVWEWL---NEHSRWRPYTATVCHHIENVLKEDA 105  

                   kGsVtleqvCsicGrpYtidfntmtQlreetgslsttReVrR<-*
                   +GsV+l+qv + +++pY+id+++m+Q+r++tg   t+R+VrR   
   mKIAA4160   106 RGSVVLGQV-DAQLVPYIIDLQSMHQFRQDTG---TMRPVRR    143  

WWE: domain 2 of 2, from 144 to 220: score 120.1, E = 4.1e-32
                   *->svappsnvagikvvvWeyerSvddnggWrpYsphvsrlIEnayaakk
                      ++++ps+++g k++vWe+e   +d+g W++Y++ ++++I+nay++++
   mKIAA4160   144    NFYDPSSAPG-KGIVWEWE---NDGGAWTAYDMDICITIQNAYEKQH 186  

                   kGsVtleqvCsicGrpYtidfntmtQlreetgslsttReVrR<-*
                   +   +l+ + s+ G++Y+i+fn+m Q++++t+   ++R+ rR   
   mKIAA4160   187 P---WLD-L-SSLGFCYLIYFNSMSQMNRQTR---RRRRLRR    220  

zf-C3HC4: domain 1 of 1, from 467 to 527: score 22.5, E = 0.0047
                   *->CrICleelkepsnd.............fplilpCgHsGslkyfCrsC
                      C IC+e l ++s +++  ++++ +++ +  +  CgH      ++  C
   mKIAA4160   467    CTICMERLVTASGYegvlrnksvrpelVGRLGRCGHM-----YHLLC 508  

                   lerwlss...sgnttCplC<-*
                   l+ ++s+++++g+ +Cp C   
   mKIAA4160   509 LVAMYSNgnkDGSLQCPTC    527  

Extensin_2: domain 1 of 1, from 256 to 543: score -136.7, E = 0.38
                   *->lltlvvalvslslpseasakYsYsSPPPpekpYvYkSPPpPspkyvy
                      l+  + a     l+s+ +     + P  p        PP P p    
   mKIAA4160   256    LVNSTRAASNAILASQRR-----KAPIAP------AAPPAP-P---- 286  

                   kSPPPpkkpYvYsSPPPPsyvykSPPPPkpyvYkSPPpPkyvYkSPPpPv
                     PPPp        P PP       PP    v  S           P+  
   mKIAA4160   287 --PPPP--------PLPP-----GGPPGALVVRPSATFAGAALWAAPATG 321  

                   ykYkSPPPPthsppPpyvykSPPPPpkkyvykSpPpptPvYkYkSPPPPp
                   +    PPP +             PP       Sp  p         P P 
   mKIAA4160   322 PTEPAPPPGV-------------PPR------SPSAPN------GAPTPG 346  

                   yvYkspPpPvkkripyvYkSPPPPpPYvYkSpPppvkkyiyksppppeph
                       s P P +        S PP +P     + p++        + p + 
   mKIAA4160   347 QNNLSRPGPQRSTSVSARASIPPGVP-----ALPVK----NLNGTGPVH- 386  

                   kYvYkSPPPPpPYvyesvpeqkikYvYkSPPPPkksYkspsp...pkyVY
                            P        +             P    + p p  +p++V 
   mKIAA4160   387 ---------PA-------LAGMTGILLCAAGLPVCLTRAPKPilhPPPVS 420  

                   kSpPpPvipykYkSPPPPkkkyspaPrkpyvYkSPPPPt...yvYkSpPp
                   kS   Pv       P  P  +   + +k+ + +  P  + ++y+ k   p
   mKIAA4160   421 KSDVKPV-------PGVP-GVCRKTKKKHLKKSKNPEDVvrrYMQKVKNP 462  

                   PykpptppkiyksPPPPtPvyvYkspPpippiksssppPvyvYkSpPppv
                   P +  t+                 +  +   + +s ++ v   kS  p  
   mKIAA4160   463 PDEDCTI-----------------CMER--LVTASGYEGVLRNKSVRPEL 493  

                   ysPPPP..yvYssPPPPvyvynsaPvykksPPkhhYiY....sSPPPphh
                          +++Y+     + + n         P    iY+++++  PP  +
   mKIAA4160   494 VGRLGRcgHMYHLLCLVAMYSNGNKDGSLQCPTCKAIYgektGTQPPGKM 543  

                   <-*
                      
   mKIAA4160     -     -    

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