hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mpj/mpj02962/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA4148  ( 498 res)   mpj02962

Scores for sequence family classification (score includes all domains):
Model          Description                              Score    E-value  N 
--------       -----------                              -----    ------- ---
Filament       Intermediate filament protein            591.7   4.5e-174   1
Filament_head  Intermediate filament head (DNA bindin    75.6    1.1e-18   1
Apolipoprotein Apolipoprotein A1/A4/E family            -99.8       0.37   1

Parsed for domains:
Model          Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
--------       ------- ----- -----    ----- -----      -----  -------
Filament_head    1/1      38   133 ..     1   105 []    75.6  1.1e-18
Apolipoprotein   1/1     117   398 ..     1   277 []   -99.8     0.37
Filament         1/1     134   442 ..     1   359 []   591.7 4.5e-174

Alignments of top-scoring domains:
Filament_head: domain 1 of 1, from 38 to 133: score 75.6, E = 1.1e-18
                   *->tssSSYRRtfGdetRlSassPrvSssspRS.........gFrSrgss
                       ssSSYRR+fG++   ++s+P  S  s RS  ++++++ +++S+ + 
   mKIAA4148    38    VSSSSYRRMFGGS--GTSSRP--S--SNRSyvttstrtySLGSALRP 78   

                   ssssv..StSrsvysvsqRSsaPspslsSsRssrlapsrlppSlaygagD
                   s s+   S+S  + +v+ RSsa  ++l+    s+++++r    l++   D
   mKIAA4148    79 STSRSlySSSPGGAYVT-RSSA--VRLR----SSVPGVR----LLQ---D 114  

                   sLDFSlAdAlNnEFKatRT<-*
                   s+DFSlAdA+N+EFK tRT   
   mKIAA4148   115 SVDFSLADAINTEFKNTRT    133  

Apolipoprotein: domain 1 of 1, from 117 to 398: score -99.8, E = 0.37
                   *->KalvlaLalllLtGcqArsfwQadePEvteqaWqqsqwdqvkdrfwv
                       +  +    +    ++ +        E        + + +  drf  
   mKIAA4148   117    DFSLADAINTEFKNTRTN--------E-------KVELQELNDRFAN 148  

                   YlrqVkdssdqaveqLessqvtqeLnl........lLednldelksyaee
                   Y++ V  +  + ++ ++ +++ ++L+ +++++ ++l e+ + el  ++++
   mKIAA4148   149 YIDKVRFL--EQQNKILLAEL-EQLKGqgksrlgdLYEEEMRELRRQVDQ 195  

                   LqeqLgPvaqefqarLsKetqalraelgkDl...EdvrnrlaPyrdEvqa
                   L ++ + v  e +++L+++  +lr++l+ ++ ++E++ + l+ +r++v +
   mKIAA4148   196 LTNDKARVEVE-RDNLAEDIMRLREKLQEEMlqrEEAESTLQSFRQDVDN 244  

                   mlgqnleeyRqrLePlare...LrkrlrrdaeeLqkrLaPyaeelRerae
                        l+ +  ++e+l +e   L+k+++++++eLq+++          ++
   mKIAA4148   245 ASLARLD-LERKVESLQEEiafLKKLHDEEIQELQAQIQ------EQHVQ 287  

                   rnVdalrerLgPyvEqlRqkaAtlltqrleeLrEraqpyaeEyke.....
                     Vd  +  L   +  +Rq+   +++ +l+e  E  +   + ++e  +++
   mKIAA4148   288 IDVDVSKPDLTAALRDVRQQYESVAAKNLQEAEEWYKSKFADLSEaanrn 337  

                   .....qleeqlselReklapvr..........edlqevltpvlEqaQlkl
                   ++  +q+++  +e R+ +  ++ + +  ++++e l+ ++  ++E+  + l
   mKIAA4148   338 ndalrQAKQESNEYRRQVQSLTcevdalkgtnESLERQMREMEEN--FAL 385  

                   qaeafqeelkkkle<-*
                    a+++q+++  +l+   
   mKIAA4148   386 EAANYQDTI-GRLQ    398  

Filament: domain 1 of 1, from 134 to 442: score 591.7, E = 4.5e-174
                   *->nEKeqmQnLNDRLAsYIdKVRfLEqqNkeLevkieelrqkqsrggpa
                      nEK ++Q+LNDR+A+YIdKVRfLEqqNk L +++e+l+++       
   mKIAA4148   134    NEKVELQELNDRFANYIDKVRFLEQQNKILLAELEQLKGQG------ 174  

                   svsrlyslYeteieeLRrqidqltnerarlqlEidnlrealedfrkKyed
                     srl++lYe+e++eLRrq+dqltn++ar+++E+dnl+e++ ++r+K+++
   mKIAA4148   175 K-SRLGDLYEEEMRELRRQVDQLTNDKARVEVERDNLAEDIMRLREKLQE 223  

                   KeDLaaQnqlkdlEialntkeaeLaTaLeRqeaEndlvgLRaQiAklEsl
                                E+ +            R+eaE  l+ +          
   mKIAA4148   224 -------------EMLQ------------REEAESTLQSF---------- 238  

                   aaRkdlDeaTLarvDLEnkvEsLqEElaFLKknHeEEvkeLqaqiqdtgq
                     R+d+D+a Lar+DLE+kvEsLqEE+aFLKk+H+EE+ eLqaqiq++ +
   mKIAA4148   239 --RQDVDNASLARLDLERKVESLQEEIAFLKKLHDEEIQELQAQIQEQ-H 285  

                   vnVEmDaarqqEwklDLtkaLrEiRaQYEeiAeknrqeaEewYksKleeL
                   v+ ++D++     k+DLt+aLr++R+QYE+ A+kn+qeaEewYksK+++L
   mKIAA4148   286 VQIDVDVS-----KPDLTAALRDVRQQYESVAAKNLQEAEEWYKSKFADL 330  

                   qtaaarngealrsaKeEitElRRqiQsLeiELqslksqnasLErqlaElE
                   ++aa+rn++alr+aK+E +E+RRq+QsL++E+++lk++n+sLErq++E+E
   mKIAA4148   331 SEAANRNNDALRQAKQESNEYRRQVQSLTCEVDALKGTNESLERQMREME 380  

                   eryeaelaqyqalisqlEeeLqqlreEMarqLrEYQeLLdVKlaLDiEIA
                   e +++e+a+yq++i++l++e+q+++eEMar+LrEYQ+LL+VK+aLDiEIA
   mKIAA4148   381 ENFALEAANYQDTIGRLQDEIQNMKEEMARHLREYQDLLNVKMALDIEIA 430  

                   TYRKLLEGEEsR<-*
                   TYRKLLEGEEsR   
   mKIAA4148   431 TYRKLLEGEESR    442  

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