hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data11/genetics/InterProScan/iprscan/data/Pfam Sequence file: /cdna4/rodent/full/goal/mbg/mbg03129/w3open/interpro/cnk_1/seq.in - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: mKIAA4141 ( 1593 res) mbg03129 Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- EGF EGF-like domain 233.8 2.4e-66 9 LRR_1 Leucine Rich Repeat 215.2 1e-60 21 Laminin_G_2 Laminin G domain 130.6 2.9e-35 1 LRRNT Leucine rich repeat N-terminal domain 125.3 1.1e-33 4 Laminin_G_1 Laminin G domain 124.3 2.2e-33 1 LRRCT Leucine rich repeat C-terminal domain 77.5 2.7e-19 4 EGF_2 EGF-like domain 49.4 8e-11 9 EGF_alliinase Alliinase EGF-like domain -8.7 1 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- LRRNT 1/4 95 122 .. 1 34 [] 39.3 8.8e-08 LRR_1 1/21 124 147 .. 1 25 [] 14.7 2.2 LRR_1 2/21 148 171 .. 1 25 [] 13.2 6.1 LRR_1 3/21 172 193 .. 1 25 [] 10.0 44 LRR_1 4/21 196 219 .. 1 25 [] 12.4 11 LRR_1 5/21 220 243 .. 1 25 [] 12.6 9.4 LRR_1 6/21 244 267 .. 1 25 [] 15.7 1.1 LRR_1 7/21 268 296 .. 1 25 [] 0.8 1.4e+03 LRRCT 1/4 301 326 .. 1 26 [] 23.0 0.0069 LRRNT 2/4 344 371 .. 1 34 [] 38.7 1.3e-07 LRR_1 8/21 373 396 .. 1 25 [] 10.2 41 LRR_1 9/21 397 420 .. 1 25 [] 22.3 0.012 LRR_1 10/21 421 444 .. 1 25 [] 14.8 2.1 LRR_1 11/21 445 468 .. 1 25 [] 9.2 60 LRR_1 12/21 469 492 .. 1 25 [] 13.4 5.5 LRRCT 2/4 526 551 .. 1 26 [] 18.1 0.21 LRRNT 3/4 569 596 .. 1 34 [] 34.2 3e-06 LRR_1 13/21 598 622 .. 1 25 [] 2.6 7.4e+02 LRR_1 14/21 623 646 .. 1 25 [] 16.3 0.71 LRR_1 15/21 647 670 .. 1 25 [] 3.6 5.1e+02 LRR_1 16/21 671 694 .. 1 25 [] 12.2 12 LRR_1 17/21 695 718 .. 1 25 [] 13.4 5.3 LRRCT 3/4 752 777 .. 1 26 [] 15.9 0.96 LRRNT 4/4 790 817 .. 1 34 [] 36.2 7.4e-07 LRR_1 18/21 819 841 .. 1 25 [] 11.5 20 LRR_1 19/21 842 865 .. 1 25 [] 17.7 0.28 LRR_1 20/21 866 889 .. 1 25 [] 16.7 0.56 LRR_1 21/21 890 913 .. 1 25 [] 16.8 0.53 LRRCT 4/4 947 972 .. 1 26 [] 21.9 0.015 EGF 1/9 986 1018 .. 1 39 [] 34.4 2.7e-06 EGF_2 1/9 986 1018 .. 1 37 [] 18.3 0.18 EGF 2/9 1025 1059 .. 1 39 [] 35.7 1e-06 EGF_2 2/9 1025 1059 .. 1 37 [] 2.3 12 EGF 3/9 1066 1097 .. 1 39 [] 40.6 3.4e-08 EGF_2 3/9 1066 1097 .. 1 37 [] 12.4 0.88 EGF 4/9 1104 1137 .. 1 39 [] 41.1 2.5e-08 EGF_2 4/9 1104 1137 .. 1 37 [] 14.1 0.57 EGF_2 5/9 1144 1175 .. 1 37 [] 14.2 0.55 EGF 5/9 1144 1175 .. 1 39 [] 43.0 6.9e-09 EGF 6/9 1189 1220 .. 1 39 [] 32.1 1.3e-05 EGF_2 6/9 1189 1220 .. 1 37 [] 22.2 0.012 Laminin_G_2 1/1 1252 1380 .. 1 141 [] 130.6 2.9e-35 Laminin_G_1 1/1 1252 1383 .. 1 154 [] 124.3 2.2e-33 EGF 7/9 1400 1431 .. 1 39 [] 28.3 0.00018 EGF_2 7/9 1400 1431 .. 1 37 [] 8.5 2.4 EGF_2 8/9 1439 1470 .. 1 37 [] 2.1 12 EGF 8/9 1439 1470 .. 1 39 [] 22.2 0.012 EGF 9/9 1480 1511 .. 1 39 [] 20.7 0.035 EGF_2 9/9 1480 1511 .. 1 37 [] 18.5 0.16 EGF_alliinase 1/1 1471 1517 .. 1 58 [] -8.7 1 Alignments of top-scoring domains: LRRNT: domain 1 of 4, from 95 to 122: score 39.3, E = 8.8e-08 *->aCpapCtCserytdglvVdCsgrgLtvavPrdlP<-* aCpa+C Cs g++VdC+g+ L+ +vPr +P mKIAA4141 95 ACPAQCSCS-----GSTVDCHGLALR-SVPRNIP 122 LRR_1: domain 1 of 21, from 124 to 147: score 14.7, E = 2.2 *->nLeeLdLsgCNpslsgslpps.l.glp<-* n e LdL+g N +++ + + ++ gl+ mKIAA4141 124 NTERLDLNG-N-NIT-RITKIdFaGLR 147 LRR_1: domain 2 of 21, from 148 to 171: score 13.2, E = 6.1 *->nLeeLdLsgCNpslsgslpps.l.glp<-* +L++L L N ++s +++ +++++l+ mKIAA4141 148 HLRVLQLME-N-RIS-TIERGaFqDLK 171 LRR_1: domain 3 of 21, from 172 to 193: score 10.0, E = 44 *->nLeeLdLsgCNpslsgslppsl.glp<-* +Le L+L++ N +l+ +p+ l l mKIAA4141 172 ELERLRLNR-N-NLQ-LFPE-LlFLG 193 LRR_1: domain 4 of 21, from 196 to 219: score 12.4, E = 11 *->nLeeLdLsgCNpslsgslpps.l.glp<-* +L LdLs N +++ +p +++g mKIAA4141 196 KLYRLDLSE-N-QIQ-AIPRKaFrGAV 219 LRR_1: domain 5 of 21, from 220 to 243: score 12.6, E = 9.4 *->nLeeLdLsgCNpslsgslpps.l.glp<-* +++L L++ N ++s ++++++++ l+ mKIAA4141 220 DIKNLQLDY-N-QIS-CIEDGaFrALR 243 LRR_1: domain 6 of 21, from 244 to 267: score 15.7, E = 1.1 *->nLeeLdLsgCNpslsgslpps.l.glp<-* Le+L L++ N +++ l+ +++++p mKIAA4141 244 DLEVLTLNN-N-NIT-RLSVAsFnHMP 267 LRR_1: domain 7 of 21, from 268 to 296: score 0.8, E = 1.4e+03 *->nLeeLdLsgCNpslsgs......lppsl.glp<-* +L++ +L++ N +l ++ + + l+++l+ p mKIAA4141 268 KLRTFRLHS-N-NLY-CdchlawLSDWLrQRP 296 LRRCT: domain 1 of 4, from 301 to 326: score 23.0, E = 0.0069 *->dlrCasPeslrGqplldlppsdfsCp<-* ++C++P++lrG+++++++ +f+C+ mKIAA4141 301 YTQCMGPSHLRGHNVAEVQKREFVCS 326 LRRNT: domain 2 of 4, from 344 to 371: score 38.7, E = 1.3e-07 *->aCpapCtCserytdglvVdCsgrgLtvavPrdlP<-* +Cpa CtCs VdC+g+gLt ++P lP mKIAA4141 344 HCPAACTCS-----NNIVDCRGKGLT-EIPTNLP 371 LRR_1: domain 8 of 21, from 373 to 396: score 10.2, E = 41 *->nLeeLdLsgCNpslsgslpps.l.glp<-* +++e++L+ N s+ + +pp++++ + mKIAA4141 373 TITEIRLEQ-N-SI-RVIPPGaFsPYK 396 LRR_1: domain 9 of 21, from 397 to 420: score 22.3, E = 0.012 *->nLeeLdLsgCNpslsgslpps.l.glp<-* +L+ LdLs+ N ++s +l+p++++gl+ mKIAA4141 397 KLRRLDLSN-N-QIS-ELAPDaFqGLR 420 LRR_1: domain 10 of 21, from 421 to 444: score 14.8, E = 2.1 *->nLeeLdLsgCNpslsgslpps.l.glp<-* +L +L L g N +++ +lp+s ++gl mKIAA4141 421 SLNSLVLYG-N-KIT-ELPKSlFeGLF 444 LRR_1: domain 11 of 21, from 445 to 468: score 9.2, E = 60 *->nLeeLdLsgCNpslsgslpps.l.glp<-* +L+ L L+ N +++ +l +++++l mKIAA4141 445 SLQLLLLNA-N-KIN-CLRVDaFqDLH 468 LRR_1: domain 12 of 21, from 469 to 492: score 13.4, E = 5.5 *->nLeeLdLsgCNpslsgslpps.l.glp<-* nL L+L + N +l+ ++++++++ l+ mKIAA4141 469 NLNLLSLYD-N-KLQ-TVAKGtFsALR 492 LRRCT: domain 2 of 4, from 526 to 551: score 18.1, E = 0.21 *->dlrCasPeslrGqplldlppsdfsCp<-* +rC+sP +l+ +++ ++ +++f C+ mKIAA4141 526 GARCTSPRRLANKRIGQIKSKKFRCS 551 LRRNT: domain 3 of 4, from 569 to 596: score 34.2, E = 3e-06 *->aCpapCtCserytdglvVdCsgrgLtvavPrdlP<-* aCp C+C+ g++VdCs++ L ++P+ +P mKIAA4141 569 ACPEKCRCE-----GTTVDCSNQRLN-KIPDHIP 596 LRR_1: domain 13 of 21, from 598 to 622: score 2.6, E = 7.4e+02 *->nLeeLdLsgCNpslsgs..lppsl.glp<-* eL+L++ N +++ + +++lp mKIAA4141 598 YTAELRLNN-N-EFT-VleATGIFkKLP 622 LRR_1: domain 14 of 21, from 623 to 646: score 16.3, E = 0.71 *->nLeeLdLsgCNpslsgslpps.l.glp<-* +L+++++s+ N +++ ++++++++g + mKIAA4141 623 QLRKINFSN-N-KIT-DIEEGaFeGAS 646 LRR_1: domain 15 of 21, from 647 to 670: score 3.6, E = 5.1e+02 *->nLeeLdLsgCNpslsgslpps.l.glp<-* + e+ L + N +l+ ++ ++gl mKIAA4141 647 GVNEILLTS-N-RLE-NVQHKmFkGLE 670 LRR_1: domain 16 of 21, from 671 to 694: score 12.2, E = 12 *->nLeeLdLsgCNpslsgslpps.l.glp<-* +L++L L++ N ++s ++ ++++ gl mKIAA4141 671 SLKTLMLRS-N-RIS-CVGNDsFiGLG 694 LRR_1: domain 17 of 21, from 695 to 718: score 13.4, E = 5.3 *->nLeeLdLsgCNpslsgslpps.l.glp<-* +++ L+L + N +++ +++p+++++l mKIAA4141 695 SVRLLSLYD-N-QIT-TVAPGaFdSLH 718 LRRCT: domain 3 of 4, from 752 to 777: score 15.9, E = 0.96 *->dlrCasPeslrGqplldlppsdfsCp<-* ++rC+ P l+ p+ d+ +df+C+ mKIAA4141 752 NPRCQKPYFLKEIPIQDVAIQDFTCD 777 LRRNT: domain 4 of 4, from 790 to 817: score 36.2, E = 7.4e-07 *->aCpapCtCserytdglvVdCsgrgLtvavPrdlP<-* Cp +CtC ++vV Cs++gL+ +P+++P mKIAA4141 790 RCPSECTCL-----DTVVRCSNKGLK-VLPKGIP 817 LRR_1: domain 18 of 21, from 819 to 841: score 11.5, E = 20 *->nLeeLdLsgCNpslsgslppsl.glp<-* ++eL+L+g N +++ +p++l++ + mKIAA4141 819 DVTELYLDG-N-QFT-LVPKELsNYK 841 LRR_1: domain 19 of 21, from 842 to 865: score 17.7, E = 0.28 *->nLeeLdLsgCNpslsgslpps.l.glp<-* +L+ +dLs+ N ++s +l++ ++++++ mKIAA4141 842 HLTLIDLSN-N-RIS-TLSNQsFsNMT 865 LRR_1: domain 20 of 21, from 866 to 889: score 16.7, E = 0.56 *->nLeeLdLsgCNpslsgslpps.l.glp<-* +L +L Ls+ N +l +++pp +++gl+ mKIAA4141 866 QLLTLILSY-N-RL-RCIPPRtFdGLK 889 LRR_1: domain 21 of 21, from 890 to 913: score 16.8, E = 0.53 *->nLeeLdLsgCNpslsgslpps.l.glp<-* +L+ L+L+g N +s +p++++++l+ mKIAA4141 890 SLRLLSLHG-N-DIS-VVPEGaFnDLS 913 LRRCT: domain 4 of 4, from 947 to 972: score 21.9, E = 0.015 *->dlrCasPeslrGqplldlppsdfsCp<-* +rCa+P +++++ ll++p+++f+C+ mKIAA4141 947 IARCAGPGEMADKLLLTTPSKKFTCQ 972 EGF: domain 1 of 9, from 986 to 1018: score 34.4, E = 2.7e-06 *->CspnngpCsngGtCvdtpg.gytCeCppGdyfllytGkrC<-* C +n pC+n+GtC++ p + y+C Cp G ++G +C mKIAA4141 986 CLSN--PCKNDGTCNNDPVdFYRCTCPYG-----FKGQDC 1018 EGF_2: domain 1 of 9, from 986 to 1018: score 18.3, E = 0.18 *->C....CngshGtCvspngtstpcgkCvCdsgyedkyqGadC<-* C +++C + +GtC+++ ++ +C C+ g + G dC mKIAA4141 986 ClsnpCKN-DGTCNNDPVD---FYRCTCPYG----FKGQDC 1018 EGF: domain 2 of 9, from 1025 to 1059: score 35.7, E = 1e-06 *->CspnngpCsngGtCvdtpg...gytCeCppGdyfllytGkrC<-* C +n pC++gGtC+ +g++ g++C C+ G + G++C mKIAA4141 1025 CISN--PCKHGGTCHLKEGenaGFWCTCADG-----FEGENC 1059 EGF_2: domain 2 of 9, from 1025 to 1059: score 2.3, E = 12 *->C....CngshGtCvspngtstpcgk...CvCdsgyedkyqGadC<-* C +++C +GtC+ +g + + C C +g + G C mKIAA4141 1025 CisnpCKH-GGTCHLKEG----ENAgfwCTCADG----FEGENC 1059 EGF: domain 3 of 9, from 1066 to 1097: score 40.6, E = 3.4e-08 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* C +n C n+ tCvd+ ++ytC Cpp ytG+ C mKIAA4141 1066 CEDN--DCENNSTCVDGINNYTCLCPPE-----YTGELC 1097 EGF_2: domain 3 of 9, from 1066 to 1097: score 12.4, E = 0.88 *->C....CngshGtCvspngtstpcgkCvCdsgyedkyqGadC<-* C++++C + + tCv+ + C C++ y+G C mKIAA4141 1066 CedndCEN-NSTCVDGIN----NYTCLCPPE----YTGELC 1097 EGF: domain 4 of 9, from 1104 to 1137: score 41.1, E = 2.5e-08 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* C+++ +pC+++ +C+ tp g++C+C+pG y G++C mKIAA4141 1104 CAQDLNPCQHDSKCILTPKGFKCDCTPG-----YIGEHC 1137 EGF_2: domain 4 of 9, from 1104 to 1137: score 14.1, E = 0.57 *->C......CngshGtCvspngtstpcg.kCvCdsgyedkyqGadC<-* C ++ ++C+ + +C+ +tp g kC+C++g y G +C mKIAA4141 1104 CaqdlnpCQH-DSKCI-----LTPKGfKCDCTPG----YIGEHC 1137 EGF_2: domain 5 of 9, from 1144 to 1175: score 14.2, E = 0.55 *->C....CngshGtCvspngtstpcgkCvCdsgyedkyqGadC<-* C++++C + + +C + +++ CvC+ g y+G C mKIAA4141 1144 CqdnkCKN-GAHCTDAVNG----YTCVCPEG----YSGLFC 1175 EGF: domain 5 of 9, from 1144 to 1175: score 43.0, E = 6.9e-09 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* C++n C+ng+ C+d +gytC Cp+G y+G +C mKIAA4141 1144 CQDN--KCKNGAHCTDAVNGYTCVCPEG-----YSGLFC 1175 EGF: domain 6 of 9, from 1189 to 1220: score 32.1, E = 1.3e-05 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* C+ C+ng++C+ +++ C+C pG y G++C mKIAA4141 1189 CDNF--DCQNGAQCIIRINEPICQCLPG-----YLGEKC 1220 EGF_2: domain 6 of 9, from 1189 to 1220: score 22.2, E = 0.012 *->C....CngshGtCvspngtstpcgkCvCdsgyedkyqGadC<-* C++ +C++ + +C+ + +C+C +g y G +C mKIAA4141 1189 CdnfdCQN-GAQCIIRIN----EPICQCLPG----YLGEKC 1220 Laminin_G_2: domain 1 of 1, from 1252 to 1380: score 130.6, E = 2.9e-35 *->FRTatqpnGlLlyaggkglpdtadpksdKflaLeLvdGrlvlrydlG + T +++G+Lly g+ +d ++a+eL Gr++ +yd G mKIAA4141 1252 IAT-DEDSGILLYKGD----------KD-HIAVELYRGRVRASYDTG 1286 sgg.vlltsg.klnDGqWHtVsverngrsvtLsVDgg.vv.g.spgssdt s + + ++s +++nDG H V++ ++s++LsVDgg++ +++ ++++ mKIAA4141 1287 SHPaSAIYSVeTINDGNFHIVELLTLDSSLSLSVDGGsPKvItNLSKQS- 1335 lslnlngplylGGlpessksslltltaaqnlvvvs.gFvGCirdvringe +ln ++ply+GG+p + + +l++++ qn ++F+GCir+++in+e mKIAA4141 1336 -TLNFDSPLYVGGMPGKNNVASLRQAPGQN----GtSFHGCIRNLYINSE 1380 <-* mKIAA4141 - - Laminin_G_1: domain 1 of 1, from 1252 to 1383: score 124.3, E = 2.2e-33 *->FRTtepsGlLllgYnGtntdrrgkkeigdDFlaleLvdGrlevsydl ++T e sG+Ll Y G+++++ a+eL +Gr++ syd+ mKIAA4141 1252 IATDEDSGILL--YKGDKDHI-----------AVELYRGRVRASYDT 1285 GsghrlrpavvrsgdrvlnDGkWHrvelerngrkgtLsVdgeervvdges Gs+ pa+ + ++++nDG+ H vel ++++LsVdg + ++ mKIAA4141 1286 GSH----PASAIYSVETINDGNFHIVELLTLDSSLSLSVDGGSP--KVIT 1329 psgpditsenLdldtppiLyvGGlPel..qksvkrrlaaistsFkGCird ++++ +L++d p LyvGG+P ++ +s + +++++tsF+GCir+ mKIAA4141 1330 NLSKQS---TLNFDSP--LYVGGMPGKnnVASLRQAPGQNGTSFHGCIRN 1374 vsingkpld<-* ++in++++d mKIAA4141 1375 LYINSELQD 1383 EGF: domain 7 of 9, from 1400 to 1431: score 28.3, E = 0.00018 *->CspnngpCsngGtCvdtpg.gytCeCppGdyfllytGkrC<-* C++ C + G C+++ ++g+tCeC +G + G+ C mKIAA4141 1400 CHKK--VCAH-GMCQPSSQsGFTCECEEG-----WMGPLC 1431 EGF_2: domain 7 of 9, from 1400 to 1431: score 8.5, E = 2.4 *->C....CngshGtCv...spngtstpcgkCvCdsgyedkyqGadC<-* C+++ C hG C +++ ++t C+C+ g + G+ C mKIAA4141 1400 ChkkvCA--HGMCQpssQSGFT------CECEEG----WMGPLC 1431 EGF_2: domain 8 of 9, from 1439 to 1470: score 2.1, E = 12 *->C....CngshGtCvspngtstpcgkCvCdsgyedkyqGadC<-* C +++C hGtC n C+C g + G C mKIAA4141 1439 ClgnkCV--HGTCLPINAF---SYSCKCLEG----HGGVLC 1470 EGF: domain 8 of 9, from 1439 to 1470: score 22.2, E = 0.012 *->CspnngpCsngGtCvdtpg.gytCeCppGdyfllytGkrC<-* C n C + GtC++ + +y+C+C +G G C mKIAA4141 1439 CLGN--KCVH-GTCLPINAfSYSCKCLEG-----HGGVLC 1470 EGF: domain 9 of 9, from 1480 to 1511: score 20.7, E = 0.035 *->CspnngpCsngGtCvdtpg.gytCeCppGdyfllytGkrC<-* C+ C++ G+C+ ++ + ++CeC G +tG+ C mKIAA4141 1480 CQMI--KCKH-GKCRLSGVgQPYCECNSG-----FTGDSC 1511 EGF_2: domain 9 of 9, from 1480 to 1511: score 18.5, E = 0.16 *->C....CngshGtCvspngtstpcgkCvCdsgyedkyqGadC<-* C+ +C hG+C+ +++ C+C+sg ++G+ C mKIAA4141 1480 CqmikCK--HGKCRLSGVG---QPYCECNSG----FTGDSC 1511 EGF_alliinase: domain 1 of 1, from 1471 to 1517: score -8.7, E = 1 *->ltWTlkAAkEAEaVAa....inCSgHGRaylDGiivsdGskPiCECn E E+ ++ + i+C HG+ l G++ + P CECn mKIAA4141 1471 --------DEEEDLFNpcqmIKC-KHGKCRLSGVG----Q-PYCECN 1503 nCYsGpDCSvllpnC<-* + ++G C ++ C mKIAA4141 1504 SGFTGDSCDREIS-C 1517 //