hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/smart.HMMs
Sequence file:            /cdna4/rodent/full/goal/mfj/mfj49110/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA4129  ( 1125 res)   mfj49110

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
PDZ      Domain present in PSD-95, Dlg, and ZO-1/2.     375.3   3.7e-108   5
GuKc     Guanylate kinase homologues.                   109.2    4.6e-28   1
WW                                                       95.0      9e-24   2

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
GuKc       1/1       5   175 ..     1   203 []   109.2  4.6e-28
WW         1/2     181   213 ..     1    34 []    51.0  1.6e-10
WW         2/2     240   272 ..     1    34 []    46.1  4.7e-09
PDZ        1/5     352   428 ..     1    80 []    75.0  9.4e-18
PDZ        2/5     523   595 ..     1    80 []    64.7  1.1e-14
PDZ        3/5     719   795 ..     1    80 []    78.0  1.2e-18
PDZ        4/5     877   963 ..     1    80 []    92.7  4.3e-23
PDZ        5/5    1029  1103 ..     1    80 []    83.3    3e-20

Alignments of top-scoring domains:
GuKc: domain 1 of 1, from 5 to 175: score 109.2, E = 4.6e-28
                   *->drRpivLsGpsGvGKstlkakLlqeyPdypkfgfsVshTTRppRpgE
                            LsG+   +K+ l+ +  + +            TTR+pR+gE
   mKIAA4129     5    -----ALSGA---QKEGLILAIGWAFAG----------TTRSPREGE 33   

                   vnGPvvDYhFvsLkeefeqdiksgkflEwgeysgnlyYGTskesvrqvae
                   v+G  vDY+F + ++ef ++++sg +lE g+y+gn yYGT+k++ ++v  
   mKIAA4129    34 VPG--VDYSFLT-VKEFLDLEQSGTLLEVGTYEGN-YYGTPKPPSQPV-- 77   

                   kGKhclLDidpqgvkqlkka.r.R.kselnpiviFIapPsleeleerlrg
                   +GK+  +D+ ++  +  k+++++R+ks++++    I +P+ ee+e+ ++ 
   mKIAA4129    78 SGKVITTDALHSLQSGSKQStPkRtKSYNDMQNAGIVHPENEEEEDVPE- 126  

                   aeqRgteteeriqkrlaaaaqkeaqeyskeahlFdlvivnddledayYke
                      ++++ +  + ++ ++   +ea  ++     +   i   ++ d   ++
   mKIAA4129   127 ---MNSSFTADSGDQDEH-TLQEATLPP-----VNSSILAAPITDPS-QK 166  

                   Lkeileaeq<-*
                   + ++l++     
   mKIAA4129   167 FPQYLPLSA    175  

WW: domain 1 of 2, from 181 to 213: score 51.0, E = 1.6e-10
                   *->plPpgWeerkdpdsGrpYYyNheTketqWekPre<-*
                      plP++We++++++ G +Y+++h+Tk+t+W +Pr    
   mKIAA4129   181    PLPENWEMAYTEN-GEVYFIDHNTKTTSWLDPRC    213  

WW: domain 2 of 2, from 240 to 272: score 46.1, E = 4.7e-09
                   *->plPpgWeerkdpdsGrpYYyNheTketqWekPre<-*
                       lP+gWe+++dp    +YY++h++++tq+e P++   
   mKIAA4129   240    ELPAGWEKIEDPV-YGVYYVDHINRKTQYENPVL    272  

PDZ: domain 1 of 5, from 352 to 428: score 75.0, E = 9.4e-18
                   *->gglGfsivg......gifvssvvpGspAakaGrkslglLkvGDvIle
                       g+Gf++vg++++++ + ++s+v ++pAa +G+     +  GDvI++
   mKIAA4129   352    RGFGFTVVGgdepdeFLQIKSLVLDGPAALDGK-----METGDVIVS 393  

                   VNGetsvegltheeavdllkkaggggvGekvtLtvlRgg<-*
                   VN+ t v g th+++v++ ++ +    G +v+L+++Rg    
   mKIAA4129   394 VND-TCVLGHTHAQVVKIFQSIPI---GASVDLELCRGY    428  

PDZ: domain 2 of 5, from 523 to 595: score 64.7, E = 1.1e-14
                   *->gglGfsivg.....gifvssvvpGspAakaGrkslglLkvGDvIleV
                       g+Gf+i+++++++g  v+++v+       G      Lk+GD I+eV
   mKIAA4129   523    MGFGFTIADspgggGQRVKQIVD--SPRCRG------LKEGDLIVEV 561  

                   NGetsvegltheeavdllkkaggggvGekvtLtvlRgg<-*
                   N  ++v+ lth ++vd+l ++++   G++vtL+v+Rgg   
   mKIAA4129   562 NK-KNVQALTHNQVVDMLIECPK---GSEVTLLVQRGG    595  

PDZ: domain 3 of 5, from 719 to 795: score 78.0, E = 1.2e-18
                   *->gglGfsivg......gifvssvvpGspAakaGrkslglLkvGDvIle
                       g+Gf+i g+++++++i++ ++vp ++A+ +Gr     L+ GD+++ 
   mKIAA4129   719    TGFGFRILGgnepgePIYIGHIVPLGAADTDGR-----LRSGDELIC 760  

                   VNGetsvegltheeavdllkkaggggvGekvtLtvlRgg<-*
                   V+G t+v g++h+ +v+l+++a ++g   +v Ltv+R+    
   mKIAA4129   761 VDG-TPVIGKSHQLVVQLMQQAAKQG---HVNLTVRRKV    795  

PDZ: domain 4 of 5, from 877 to 963: score 92.7, E = 4.3e-23
                   *->gglGfsivg..................gifvssvvpGspAakaGrks
                      +g+Gf iv++ ++++ +++ ++     ++ + ++++GspA+++G+  
   mKIAA4129   877    EGFGFVIVSsvsrpeagttfgnacvamPHKIGRIIEGSPADRCGK-- 921  

                   lglLkvGDvIleVNGetsvegltheeavdllkkaggggvGekvtLtvlRg
                      LkvGD+Il+VNG  s+++++h ++v+l+k+ag+     +vtL +++g
   mKIAA4129   922 ---LKVGDRILAVNG-CSITNKSHSDIVNLIKEAGN-----TVTLRIIPG 962  

                   g<-*
                   +   
   mKIAA4129   963 D    963  

PDZ: domain 5 of 5, from 1029 to 1103: score 83.3, E = 3e-20
                   *->gglGfsivg......gifvssvvpGspAakaGrkslglLkvGDvIle
                      +g+Gfs++g+++ +  ++v ++ +++pA+++G+     +++GD+Ile
   mKIAA4129  1029    KGFGFSLRGgreynmDLYVLRLAEDGPAERCGK-----MRIGDEILE 1070 

                   VNGetsvegltheeavdllkkaggggvGekvtLtvlRgg<-*
                   +NG + ++++ h +a++l+k+ g+     +v+L ++Rg+   
   mKIAA4129  1071 ING-ETTKNMKHSRAIELIKNGGR-----RVRLFLRRGD    1103 

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