hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mic/mic04070/w3open/interpro/cnk_1/seq.in
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query:  mKIAA4126  ( 1285 res)   mic04070

Scores for sequence family classification (score includes all domains):
Model         Description                               Score    E-value  N 
--------      -----------                               -----    ------- ---
HDAC_interact Histone deacetylase (HDAC) interacting    220.7    2.2e-62   1
PAH           Paired amphipathic helix repeat           181.4    1.5e-50   3
Extensin_2    Extensin-like region                     -142.3       0.65   1

Parsed for domains:
Model         Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
--------      ------- ----- -----    ----- -----      -----  -------
PAH             1/3     149   195 ..     1    47 []    77.5  2.8e-19
Extensin_2      1/1      16   334 ..     1   385 []  -142.3     0.65
PAH             2/3     330   389 ..     1    47 []    52.1  1.2e-11
PAH             3/3     486   532 ..     1    47 []    52.0  1.3e-11
HDAC_interact   1/1     559   659 ..     1   102 []   220.7  2.2e-62

Alignments of top-scoring domains:
PAH: domain 1 of 3, from 149 to 195: score 77.5, E = 2.8e-19
                   *->pekYksFlkiLnmykkkridkdeliarvseLlkdhpdLlegFsaFlp
                      p++Y++Fl+i++++k++ id +++i+rvs+L+k+hpdL++gF+ Flp
   mKIAA4126   149    PQVYNDFLDIMKEFKSQSIDTPGVISRVSQLFKGHPDLIMGFNTFLP 195  

                   <-*
                      
   mKIAA4126     -     -    

Extensin_2: domain 1 of 1, from 16 to 334: score -142.3, E = 0.65
                   *->lltlvvalvslslpseasa...kYsYsSPPPpekpYvYkSPPpPspk
                        ++v a     +p +++a +++     P Pp   Y   S    s  
   mKIAA4126    16    QESPVYAAQQRRIPGSTEAfshQHRVLAPAPP--VYEAVSETMQSAT 60   

                   yvykSPPPpkkpYvYsSPPPPsyvykSPPPPkpyvYkSPPpPkyvYkSPP
                    +  S  P    Y  s  P       S  P    v +S   P+ v     
   mKIAA4126    61 GIQYSVAPN---YQVSAVPQS---SGSHGPAIAAVHSSHHHPTAVQPHGG 104  

                   pPvykYkSPPPPthsppPpyvykSPPPPpkkyvykSpPpptPvYkYkSPP
                     v     P PP+     +  ++      k+    S      +  + S P
   mKIAA4126   105 QVVQSHAHPAPPVAPVQGQQQFQR----LKVEDALSYLDQV-KLQFGSQP 149  

                   PPpyvYkspPpPvkkripyvYkSPPPPpPYvYkSpPppvkkyiykspppp
                       vY+     +k+   ++ +S   P         +++   ++k  p  
   mKIAA4126   150 ---QVYNDFLDIMKE---FKSQSIDTPGV-----ISRVS--QLFKGHPDL 186  

                   ephkYvYkSPPPPpPYvyesvpeqkikYvYkSPPPPkksYkspsppkyVY
                         ++   PP  Y+ e + ++ +         P ++++      + +
   mKIAA4126   187 ---IMGFNTFLPPG-YKIEVQTNDMVNVT-----TPGQVHQ-----IPTH 222  

                   kSpPpPvipykYkSPPPPkkkyspaPrkpyvYkSPPP.PtyvYkSpPpPy
                      P P         PPP+++ +p+ +  +    P P+Pt    S P   
   mKIAA4126   223 GIQPQPQ--------PPPQHPSQPSSQSAPTPAQPAPqPTAAKVSKPSQL 264  

                   kpptppkiyksPPPPtPvyvYkspPpippiksssppPvyvYkSpPppvys
                   ++ tp+     P PP     Y sp   pp  +++ +Pv       p  + 
   mKIAA4126   265 QAHTPASQQTPPLPP-----YASPRS-PP--VQPHTPVTISLGTAPSLQN 306  

                   PPPPyvYssPPPPvyvynsaPvykksPPkhhYiYsSPPPphh<-*
                     P             +n a  y++   k+   +   P  +    
   mKIAA4126   307 NQPV-----------EFNHAINYVN---KIKNRFQGQPDIYK    334  

PAH: domain 2 of 3, from 330 to 389: score 52.1, E = 1.2e-11
                   *->pekYksFlkiLnmykkkridkd.............eliarvseLlkd
                      p++Yk+Fl+iL+ y+k++ ++++ +++ ++  +++e++a+v+ L+k 
   mKIAA4126   330    PDIYKAFLEILHTYQKEQRNAKeaggnytpalteqEVYAQVARLFKN 376  

                   hpdLlegFsaFlp<-*
                    +dLl +F +Flp   
   mKIAA4126   377 QEDLLSEFGQFLP    389  

PAH: domain 3 of 3, from 486 to 532: score 52.0, E = 1.3e-11
                   *->pekYksFlkiLnmykkkridkdeliarvseLlkdhpdLlegFsaFlp
                       e+Y+ Fl++L  ++++ i+++el++ vs++l+  p+L+++F++Fl 
   mKIAA4126   486    AEAYENFLRCLVIFNQEVISRAELVQLVSPFLGKFPELFNWFKNFLG 532  

                   <-*
                      
   mKIAA4126     -     -    

HDAC_interact: domain 1 of 1, from 559 to 659: score 220.7, E = 2.2e-62
                   *->nCkrcgpSYRlLPkseplppCSgRddlcweVLNDhWVSvPTwaSEDs
                      +Ckr+g+SYR+LPks+++p+C+gR+ lc+eVLND+WVS+P+w+ EDs
   mKIAA4126   559    SCKRLGSSYRALPKSYQQPKCTGRTPLCKEVLNDTWVSFPSWS-EDS 604  

                   gFvhhRKNQYEEsLfrcEDERfElDrvlEsnsstIkvLeellekinnmsl
                   +Fv+++K+QYEE ++rcEDERfElD+vlE+n++tI+vLe +++k++++s 
   mKIAA4126   605 TFVSSKKTQYEEHIYRCEDERFELDVVLETNLATIRVLEAIQKKLSRLSA 654  

                   eeksk<-*
                   ee++k   
   mKIAA4126   655 EEQAK    659  

//