hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/smart.HMMs
Sequence file:            /cdna4/rodent/full/goal/mbg/mbg03907/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA4097  ( 1033 res)   mbg03907

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
RhoGAP   GTPase-activator protein for Rho-like GTPase   172.7    3.6e-47   1
ArfGap   Putative GTP-ase activating proteins for the    99.6    3.7e-25   1
PH       Pleckstrin homology domain.                     75.9    5.1e-18   3

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
ArfGap     1/1      55   177 ..     1   139 []    99.6  3.7e-25
PH         1/3     242   356 ..     1    82 []     6.9       35
PH         2/3     366   472 ..     1    82 []    25.3   0.0084
RhoGAP     1/1     484   660 ..     1   193 []   172.7  3.6e-47
PH         3/3     791   894 ..     1    82 []    42.9  4.3e-08

Alignments of top-scoring domains:
ArfGap: domain 1 of 1, from 55 to 177: score 99.6, E = 3.7e-25
                   *->eealqlLRsikpgNkkCfDCGavpnPtWaSvnlGvflCieCSGiHRs
                       e  +++ s++  N++C+DC a   P+Wa vnlGv++C +C+G HR 
   mKIAA4097    55    YEVAEKVWSNP-ANRHCADCRA-SRPDWAAVNLGVVICKQCAGQHRA 99   

                   LfGvHiSkVnvRSltLD..tWteeeLrllesckgGNenansfwesnlddf
                   L G  iSkV   Sl+LD++ W  e ++l+    +GN++an fw + l++ 
   mKIAA4097   100 L-GSGISKV--QSLKLDtsVWSNEIVQLFI--VLGNDRANCFWAGALPPG 144  

                   slkpkdsdaaasvKCeddrqkyesfiaaKYeeklfrvdkesaee<-*
                   +   +ds          ++  + +fi  KY+  lf  ++ ++ +   
   mKIAA4097   145 EGLHPDS----------APGPRGEFISRKYKLGLF-RKPHPRHP    177  

PH: domain 1 of 3, from 242 to 356: score 6.9, E = 35
                   *->vikeGwLlkks.............k.swkkryfvLfngvLlyyksk.
                       +++G+L+  s +++ + ++ +++++   + ++vL    L  + s++
   mKIAA4097   242    ATYRGFLYCGSisnkagapplrrgRdAPPRLWCVLGA-ALEMFASEs 287  

                   .....kpkgsipLsgcsvre.p...........cFeivt.dr.tlllqAe
                   ++++ ++  + ++  + v+++p ++++ ++ + +Fe++ ++++  +++++
   mKIAA4097   288 speplSLLQPQDIVCLGVSPpPadpgdldrfpfSFELILtGGrIQHFATD 337  

                   seeereeWvealqsaiaka<-*
                    ++++e W++a  +  +++   
   mKIAA4097   338 GADSLEAWISAVGKWFSPL    356  

PH: domain 2 of 3, from 366 to 472: score 25.3, E = 0.0084
                   *->vikeGwLlkks.......k.swkkryfvLfngvLlyyksk.....kp
                      +++ G L  +s+++ +   + w   +  L+++ L+++  +++++++p
   mKIAA4097   366    LLRMGRLWLRSpshaglaPgLWLSGFGLLRGDHLFLCPAPgpgppAP 412  

                   kgsipLsgc.svre.p.........cFeivt.drtlllqAeseeereeWv
                     +++L+ ++++++    + +++++ + +v ++rtl+lq e   ++  W 
   mKIAA4097   413 EDMVHLRRLqEISVvSaadtpdkkeHLVLVEtGRTLYLQGEGRLDFAAWN 462  

                   ealqsaiaka<-*
                   +a+  a+      
   mKIAA4097   463 TAIGGAAGGG    472  

RhoGAP: domain 1 of 1, from 484 to 660: score 172.7, E = 3.6e-47
                   *->spiPiivekCieylekrGldteGIYRvsGsksrvkeLreafdsged.
                      ++iPiiv+ Ci+++ ++Gl+ eG+YR+ G + r  +L+++f+++  +
   mKIAA4097   484    GDIPIIVDACISFVTQHGLRLEGVYRKGGARARSLRLLAEFRRDARs 530  

                   dldsldesiteesedleeydvhdvAglLKlyLReLPePLltfelyeefie
                   +           ++  +e+ v dv++ LK+++ReL +P+   +l ++++e
   mKIAA4097   531 V-----------KLRPREHFVEDVTDTLKRFFRELDDPVTSARLLPRWRE 569  

                   aaklyqieatsrkqseksedeeerlralrellslLPpanratLryLl.HL
                   aa+l              + + +rl++++e++s+LP++nr+tL  L++HL
   mKIAA4097   570 AAEL--------------SQKNQRLEKYKEVISCLPRVNRRTLATLIgHL 605  

                   nrVaehsevNkMtarNLAivFgPtLlrpp.......ltdikhqnkvvetl
                   +rV+++++ N M  rNLA+ F+P+ ++ +++++++  ++ ++++ ++ ++
   mKIAA4097   606 YRVQKCASLNQMCTRNLALLFAPSVFQTDgrgehevRVLQELIDGYISVF 655  

                   ienad<-*
                     ++d   
   mKIAA4097   656 DIDSD    660  

PH: domain 3 of 3, from 791 to 894: score 42.9, E = 4.3e-08
                   *->vikeGwLlkks......k.swkkryfvLfngvLlyyksk...kpkgs
                        + G L+ ++ +++  ++++++r+f +++++Ll+ k+k+++kp  +
   mKIAA4097   791    SPRVGLLRCREepprllGnRFQERFFLVRGRCLLLLKEKkssKPERE 837  

                   ipLsgcsvre.p..........cFeivt.drtlllqAeseeereeWveal
                    +L+g++v+ + +++ +++   +F+++ ++  l l++ +eee+ +W +++
   mKIAA4097   838 WSLEGAKVYLgIrkklkpptlwGFTLILeKMHLCLSCMDEEEMWDWTTSI 887  

                   qsaiaka<-*
                    +a+++    
   mKIAA4097   888 LKAQHDD    894  

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