hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mbg/mbg03907/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA4097  ( 1033 res)   mbg03907

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
RhoGAP   RhoGAP domain                                  194.4    1.8e-54   1
ArfGap   Putative GTPase activating protein for Arf     112.3    9.4e-30   1
RA       Ras association (RalGDS/AF-6) domain            75.1    1.4e-18   1
PH       PH domain                                       52.8    7.3e-12   3

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
ArfGap     1/1      55   177 ..     1   137 []   112.3  9.4e-30
PH         1/3     247   354 ..     1    92 []     2.0       13
PH         2/3     366   470 ..     1    92 []    18.7     0.14
RhoGAP     1/1     487   638 ..     1   155 []   194.4  1.8e-54
RA         1/1     684   777 ..     1    98 []    75.1  1.4e-18
PH         3/3     791   892 ..     1    92 []    31.5  1.9e-05

Alignments of top-scoring domains:
ArfGap: domain 1 of 1, from 55 to 177: score 112.3, E = 9.4e-30
                   *->qrvlqlLrsldpgNkkCfDCgavpnPtWaSvnlGvflCieCSGiHRn
                       +v +++ s++  N++C+DC a   P+Wa vnlGv++C +C+G HR 
   mKIAA4097    55    YEVAEKVWSNP-ANRHCADCRA-SRPDWAAVNLGVVICKQCAGQHRA 99   

                   LfGvHiSkVnvRSltLD..sWtpeeLrklesckgGNenansfwEsnlddf
                   L G  iSkV   Sl+LD++ W  e ++++   ++GN++an fw + l++ 
   mKIAA4097   100 L-GSGISKV--QSLKLDtsVWSNEIVQLFI--VLGNDRANCFWAGALPPG 144  

                   slkpkdsdaaavKCqddrqkyesfiaaKYeeklfvlkeeqee<-*
                   +   +ds+         +  + +fi  KY+  lf ++ ++ +   
   mKIAA4097   145 EGLHPDSA---------PGPRGEFISRKYKLGLFRKPHPRHP    177  

PH: domain 1 of 3, from 247 to 354: score 2.0, E = 13
                   *->vikeGwLlkkg......gkkswkkRyfvLfndvLlyykdkk....kk
                        ++G ++ k + ++ ++++   +R  ++ +  L+++ +++++++ +
   mKIAA4097   247    FLYCGSISNKAgapplrRGRDAPPRLWCVLGAALEMFASESspepLS 293  

                   pkgsipLsgiqvekvpdn.....krkncFeirt.dretlllqaeseeerk
                   +    ++  + v ++p+ +++ ++ +++Fe++ ++++  +++++ +++++
   mKIAA4097   294 LLQPQDIVCLGVSPPPADpgdldRFPFSFELILtGGRIQHFATDGADSLE 343  

                   eWvkaiqsair<-*
                    W++a  +  +   
   mKIAA4097   344 AWISAVGKWFS    354  

PH: domain 2 of 3, from 366 to 470: score 18.7, E = 0.14
                   *->vikeGwLlkkg......gkkswkkRyfvLfndvLlyykdkk......
                      + ++G L+++++++ + + + w   +  L++d L+++  ++++++ +
   mKIAA4097   366    LLRMGRLWLRSpshaglAPGLWLSGFGLLRGDHLFLCPAPGpgppap 412  

                   kkpkgsipLsgiqvekvpdn.krkncFeirt.dretlllqaeseeerkeW
                   ++ ++   L++i+v+ + d++++k  ++++ ++r tl+lq e   +   W
   mKIAA4097   413 EDMVHLRRLQEISVVSAADTpDKKEHLVLVEtGR-TLYLQGEGRLDFAAW 461  

                   vkaiqsair<-*
                    +ai  a+    
   mKIAA4097   462 NTAIGGAAG    470  

RhoGAP: domain 1 of 1, from 487 to 638: score 194.4, E = 1.8e-54
                   *->PlivekCieflekrGLdtEGIyRvsGsksrikeLreafdrgedvdln
                      P+iv+ Ci+f+ ++GL+ EG yR+ G ++r  +L ++f+r+++ +++
   mKIAA4097   487    PIIVDACISFVTQHGLRLEGVYRKGGARARSLRLLAEFRRDARSVKL 533  

                   dleeedvhvvAslLKlFLReLPePLltfelyeefieaaaksedeeerlea
                    ++e+ v +v++ LK+F+ReL +P+ + +l +++ e aa++  + +rle+
   mKIAA4097   534 RPREHFVEDVTDTLKRFFRELDDPVTSARLLPRWRE-AAELSQKNQRLEK 582  

                   lrellrkLPpaNrdtLryLlahLnrVaqnsevNkMtahNLAivFgPtLlr
                   ++e++++LP++Nr+tL+ L++hL+rV+++++ N+M  +NLA+ F+P+ ++
   mKIAA4097   583 YKEVISCLPRVNRRTLATLIGHLYRVQKCASLNQMCTRNLALLFAPSVFQ 632  

                   ppdgdsad<-*
                   ++   +++   
   mKIAA4097   633 TDG--RGE    638  

RA: domain 1 of 1, from 684 to 777: score 75.1, E = 1.4e-18
                   *->dsgvlrVygedgtpgtyktilvskntTaeeViralLrKfgldaddpe
                      ++ ++ Vy e + p++++t++vs++ Taee+ +++L+++g  a  ++
   mKIAA4097   684    GDLIMEVYIEQQLPDNCVTLKVSPTLTAEELTNQVLEMRGA-ASGTD 729  

                   dyvLvEvslvlerggeerrvLpddEkPlqiqlqlkrdaqv.rsrFlLrrr
                    +v +E    le+g+ er +L++ Ek+l+  lq+++ +++ + ++lLr+ 
   mKIAA4097   730 LWVTFE---ILEHGELER-PLHPKEKVLEQALQWCQLPEPcSASLLLRKV 775  

                   ed<-*
                   +    
   mKIAA4097   776 SM    777  

PH: domain 3 of 3, from 791 to 892: score 31.5, E = 1.9e-05
                   *->vikeGwLlkkg.....gkkswkkRyfvLfndvLlyykdkk.kkpkgs
                        + G L+ ++++++  + ++++R+f +++++Ll+ k+kk++kp + 
   mKIAA4097   791    SPRVGLLRCREepprlLGNRFQERFFLVRGRCLLLLKEKKsSKPERE 837  

                   ipLsgiqvekvpdn....krkncFeirt.dretlllqaeseeerkeWvka
                   ++L+g++v+   + + ++++  +F+++ +   +l l++ +eee+ +W ++
   mKIAA4097   838 WSLEGAKVYLGIRKklkpPTLWGFTLILeKM-HLCLSCMDEEEMWDWTTS 886  

                   iqsair<-*
                   i +a++   
   mKIAA4097   887 ILKAQH    892  

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