hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data11/genetics/InterProScan/iprscan/data/Pfam Sequence file: /cdna4/rodent/full/goal/mbg/mbg12616/w3open/interpro/cnk_1/seq.in - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: mKIAA4089 ( 1251 res) mbg12616 Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- 7tm_2 7 transmembrane receptor (Secretin family) 317.5 1.6e-91 1 TSP_1 Thrombospondin type 1 domain 172.8 5.8e-48 4 GPS Latrophilin/CL-1-like GPS domain 79.7 6.1e-20 1 HRM Hormone receptor domain 61.7 1.6e-14 1 7tm_1 7 transmembrane receptor (rhodopsin family) -94.4 0.25 1 7tm_3 7 transmembrane receptor (metabotropic gluta -143.4 0.54 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- TSP_1 1/4 22 70 .. 1 55 [] 40.2 4.7e-08 TSP_1 2/4 77 125 .. 1 55 [] 57.6 2.7e-13 TSP_1 3/4 135 183 .. 1 55 [] 41.0 2.6e-08 TSP_1 4/4 190 238 .. 1 55 [] 57.6 2.7e-13 HRM 1/1 242 303 .. 1 76 [] 61.7 1.6e-14 GPS 1/1 544 602 .. 1 55 [] 79.7 6.1e-20 7tm_1 1/1 629 851 .. 1 272 [] -94.4 0.25 7tm_2 1/1 608 855 .. 1 296 [] 317.5 1.6e-91 7tm_3 1/1 613 857 .. 1 279 [] -143.4 0.54 Alignments of top-scoring domains: TSP_1: domain 1 of 4, from 22 to 70: score 40.2, E = 4.7e-08 *->spWseWSpCSVTCGkGirtRqRvcnspaPqkkggepCtgdvqelete +Ws+WS CS TCG+G +tR+ c+s + + +C g+ +e + mKIAA4089 22 EEWSPWSVCSSTCGEGWQTRTHFCVSS----SYSTQCSGPLRE--QR 62 aCdmmdkC<-* C++ C mKIAA4089 63 LCNNSAVC 70 TSP_1: domain 2 of 4, from 77 to 125: score 57.6, E = 2.7e-13 *->spWseWSpCSVTCGkGirtRqRvcnspaPqkkggepCtgdvqelete +Ws+WS CS TCG G r R+R+c p Pq +gg+pC+g+ + t+ mKIAA4089 77 DEWSPWSLCSSTCGRGFRDRTRTCR-P-PQ-FGGNPCEGPEKQ--TK 118 aCdmmdkC<-* C + C mKIAA4089 119 FC-NIALC 125 TSP_1: domain 3 of 4, from 135 to 183: score 41.0, E = 2.6e-08 *->spWseWSpCSVTCGkGirtRqRvcnspaPqkkggepCtgdvqelete +Ws WS CS +C+ G ++R+R cn+p+ +gg+ C g +e t+ mKIAA4089 135 NEWSSWSTCSASCSQGRQQRTRECNGPS---YGGAECQGHWVE--TR 176 aCdmmdkC<-* C + C mKIAA4089 177 DC-FLQQC 183 TSP_1: domain 4 of 4, from 190 to 238: score 57.6, E = 2.7e-13 *->spWseWSpCSVTCGkGirtRqRvcnspaPqkkggepCtgdvqelete W W +CSVTCG+G++ R Rvc +p+ +gg+ C g++ e + mKIAA4089 190 QAWASWGSCSVTCGGGSQRRERVCSGPF---FGGAACQGPQDE--YR 231 aCdmmdkC<-* C ++ C mKIAA4089 232 QC-GAQRC 238 HRM: domain 1 of 1, from 242 to 303: score 61.7, E = 1.6e-14 *->glgCpatwDgivCWPrtpaGqlvvvpCPdyfsGfnydttgedfgnay ++ C ++ g v W++tpaG++++v CP+++ G + mKIAA4089 242 HEICDEDNFGAVVWKETPAGEVAAVRCPRNATGL----------ILR 278 RnCtenGwwerhpsnwpwpnysaCtsney<-* R+ +++ + + w++p y++C+s++y mKIAA4089 279 RCELDEEGIA----FWEPPTYIRCVSIDY 303 GPS: domain 1 of 1, from 544 to 602: score 79.7, E = 6.1e-20 *->tnpiCvfWdessl......estgvWstdrGCevveenkpshttCsCn tn++C++Wde++ ++++ ++++g Ws+ rGC++v++++ +t+C+C+ mKIAA4089 544 TNQTCILWDETDGpsssapPQLGPWSW-RGCRTVPLDA-LRTRCLCD 588 HLTtFAvlmdvppn<-* +L+tFA+l++++++ mKIAA4089 589 RLSTFAILAQLSAD 602 7tm_1: domain 1 of 1, from 629 to 851: score -94.4, E = 0.25 *->GNlLVilvilrtkklrtptnifilNLAvADLLflltlppwalyylvg l++i+v ++ + r+ ++ ++N f+l+ ++++l+g mKIAA4089 629 --LVIIYVSVW-RYIRSERSVILIN-------FCLSIISSNALILIG 665 gedWpfGsalCklvtaldvvnmyaSillLtaISiDRYlAIvhPlryrrrr + + +++C lv a+ +++ +S + + + Y A++ r+r mKIAA4089 666 -QTQTRNKVVCTLVAAFLHFFFLSSFCWVLTEAWQSYMAVT-----GRLR 709 tsprrAkvvillvWvlalllslPpllfswvktveegngvvnvttClidfp + + + k ++l W l +l+ + ++++ ++ ++C+++ + mKIAA4089 710 S-RLVRKRFLCLGWGLPALVVAIS-VGFTKAKGYST-----MNYCWLSLE 752 evstasvstwlvsyvllstlvgFllPllvilvcYtrIlrtlrkrarkgas + +l +F+ P + +++I + +++ +++ + mKIAA4089 753 GG----------------LLYAFVGPAAAVVLVNMVIGILVFNKLVSKDG 786 ...kkrsskerkaaktllvvvvvFvlCWlPyfivllldtlc.lsiimsst ++kk + + ++ +vv+ + +l W+ +++ + + + i mKIAA4089 787 itdKKLKERAGASLWSSCVVLPLLALTWMSAVLAVTDRRSAlFQIL---- 832 CelervlptallvtlwLayvNsclNPiIY<-* + + l ++ +v+++l mKIAA4089 833 -----FAVFDSLEGFVIVMVHCIL----- 851 7tm_2: domain 1 of 1, from 608 to 855: score 317.5, E = 1.6e-91 *->lllLkviytVGyslSSLvaLllAiaifllfRkLhCtRnyIHlNLfas ++++v+ +VG+++SSL+ L+l i++ + +R ++++R+ I++N+++s mKIAA4089 608 VTVPSVTLIVGCGVSSLTLLMLVIIYVSVWRYIRSERSVILINFCLS 654 fiLralsfLikdavlfnsvglseadqlsweeslhcsasagkitmivvVgC +i +++++Li++++++n+v C mKIAA4089 655 IISSNALILIGQTQTRNKVV-----------------------------C 675 kvvavflhYfflaNFfWmLVEGlYLhtllvvtvevffserkrfwwYlliG ++va+flh+ffl++F+W+L+E+++ ++++ t ++ + r+ ++++l++G mKIAA4089 676 TLVAAFLHFFFLSSFCWVLTEAWQSYMAV--T--GRLRSRLVRKRFLCLG 721 WGvPavfvgiwaivrpdkwagygnegCCWlsnedngyfwWiikGPvllvI WG+Pa++v+i++++++ k gy ++++CWls+ +g++++ ++GP+++v+ mKIAA4089 722 WGLPALVVAISVGFTKAK--GYSTMNYCWLSL--EGGLLYAFVGPAAAVV 767 lvNfilFinilriLvqKlri.dkslspqmgetdqyrkkrlakstLlLlPL lvN+++ i+++++Lv+K i+dk+l+ ++g ++++s+++ lPL mKIAA4089 768 LVNMVIGILVFNKLVSKDGItDKKLKERAG--------ASLWSSCVVLPL 809 LGitwvlflfapeddsqGvssivflylfliLnSfQGffVavlYCFlNgEV L +tw+ +++a++d+ +s+ f+ lf+++ S+ Gf++ + +C l++EV mKIAA4089 810 LALTWMSAVLAVTDR----RSALFQILFAVFDSLEGFVIVMVHCILRREV 855 <-* mKIAA4089 - - 7tm_3: domain 1 of 1, from 613 to 857: score -143.4, E = 0.54 *->lvalAvlGLivlTlfVlvvFvkhrdTPiVKAsnreLSYlLLiglilc ++++ +G ++ ++v ++ ++++ s r+ +l+ + l++ mKIAA4089 613 VTLIVGCG-VSSLTLLMLVIIYVSVWRYIR-SERSV-ILINFCLSII 656 flcsflFIgkGtvekPsewsCiLRrilfGlgFtlcySalLaKTirVlraF ++ +++Ig+ ++ + ++C+L ++ F ++ +L+ +++ ++a mKIAA4089 657 SSNALILIGQ--TQTRNKVVCTLVAAFLHFFFLSSFCWVLTEAWQSYMAV 704 rkatkpgsgqrrk...fispwaqvlivliltliQ.....viicviWLvve + +++ ++ +rk+ +++ + + l v i ++ + ++ + +WL +e mKIAA4089 705 T-GRLRSRL-VRKrflCLGWGLPALVVAISVGFTkakgySTMNYCWLSLE 752 PPrpdkdihsekekeedeDvsiapiileCnkgsvvaFvvvLgYlglLavl + +g+++a v v+ +g+L + mKIAA4089 753 GGLL----YAF-------------------VGPAAAVVLVNMVIGILVFN 779 cffl..AfltRklPvdnFNEAKfItFSMYNvltfCiVWvAFiPi.Ylstp ++ ++ + +kl+ ++ A + + S ++ + ++++ + +t+ mKIAA4089 780 KLVSkdGITDKKLK-ER---AGASLWSS--CVVLPLLALTWMSAvLAVTD 823 gsaedykvqvaveifsIlaSStglLgciFaPKcYIILfkPekn<-* + + + f++ S g+++++ +++IL ++ ++ mKIAA4089 824 R-----RSALFQILFAVFDSLEGFVIVM----VHCILRREVQD 857 //