hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mph/mph00951/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA4088  ( 652 res)   mph00951

Scores for sequence family classification (score includes all domains):
Model       Description                                 Score    E-value  N 
--------    -----------                                 -----    ------- ---
Pkinase     Protein kinase domain                       353.5   2.2e-102   1
Pkinase_Tyr Protein tyrosine kinase                     121.1    2.1e-32   1
RIO1        RIO1 family                                 -87.4      0.025   1

Parsed for domains:
Model       Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
--------    ------- ----- -----    ----- -----      -----  -------
RIO1          1/1      91   240 ..     1   203 []   -87.4    0.025
Pkinase_Tyr   1/1      78   326 ..     1   272 []   121.1  2.1e-32
Pkinase       1/1      78   328 ..     1   287 []   353.5 2.2e-102

Alignments of top-scoring domains:
RIO1: domain 1 of 1, from 91 to 240: score -87.4, E = 0.025
                   *->nVYhAvsyaedgedptevAvKiyrtgtteFkk.rkkYrdgdfRFrdr
                       V +A+   ++g+    vA+K          + rk +++++++  ++
   mKIAA4088    91    KVKKARE--SSGR---LVAIK----------SiRKDKIKDEQDLLHI 122  

                   ksktswrklvrlWAeKEfrNLkRLyeaGvpVPkPiavnrh....vLVMEf
                                 ++E ++++ L   +  + + ++v++++++ v+VME+
   mKIAA4088   123 --------------RREIEIMSSLNHPH--IIAIHEVFENsskiVIVMEY 156  

                   IgdedGvpAPrLkdveleldlseeeaeelYdeiirEymrrlYkeagLVHG
                    +  +G+    + + +   +lse++a++ +++i+   ++     +g+VH 
   mKIAA4088   157 AS--RGDLYDYISERP---RLSERDARHFFRQIVS-ALHYCH-QNGIVHR 199  

                   DLSEYNiLvhddgkpviIDvsQaVetdHPnAlefLeRDieNIinFFrrkg
                   DL   NiL++ +g++ i D++   +                 + + + k+
   mKIAA4088   200 DLKLENILLDANGNIKIADFG--LS-----------------NLYHKGKF 230  

                   vdkrvvdvrel<-*
                       ++  + +   
   mKIAA4088   231 LQT-FCGSPLY    240  

Pkinase_Tyr: domain 1 of 1, from 78 to 326: score 121.1, E = 2.1e-32
                   *->lklgkkLGeGaFGeVykGtlkgsgegtkikVAVKtL.ke.igassee
                       +++++LG+G +G+V k++        +  VA+K+++k++i+  ++ 
   mKIAA4088    78    YEFLETLGKGTYGKVKKARES-----SGRLVAIKSIrKDkIKDEQD- 118  

                   ieredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegG
                     +    rE++iM++l +Hp+i+  + v    +      + iV+Ey+  G
   mKIAA4088   119 --LLHIRREIEIMSSL-NHPHIIAIHEVFEN-SSK----IVIVMEYASRG 160  

                   dLldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcL
                   dL+d+  +   +++L+  d  +f +Qi +++ Y +++++vHRDL   N+L
   mKIAA4088   161 DLYDYISE---RPRLSERDARHFFRQIVSALHYCHQNGIVHRDLKLENIL 207  

                   VsenlvVKIsDFGLaRdiynddyYvrkkgggklPvkWmAPEslkygk..F
                   ++ n+ +KI+DFGL+ + ++     ++  g++l     +PE + +gk+  
   mKIAA4088   208 LDANGNIKIADFGLSNLYHKGKFL-QTFCGSPL---YASPE-IVNGKpyV 252  

                   tskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprPenC
                     + D WS GVlL+ i+  G +P + g +   +++++  +G   ++P+  
   mKIAA4088   253 GPEVDSWSLGVLLY-ILVHGTMP-FDGQDHKTLVKQI-SNGAYREPPK-- 297  

                   PdelYdlMlqCWaedPedRPtFselverL<-*
                   P +   l++   + +P +R t +++ ++    
   mKIAA4088   298 PSDACGLIRWLLMVNPTRRATLEDVASHW    326  

Pkinase: domain 1 of 1, from 78 to 328: score 353.5, E = 2.2e-102
                   *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr
                      ye+le+lG+G++G+V+ka++ + +  VA+K i+k+k+k+++d  ++r
   mKIAA4088    78    YEFLETLGKGTYGKVKKARESSGRL-VAIKSIRKDKIKDEQDLLHIR 123  

                   rsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrlldLfdylse
                   r Ei+i+ +L+Hp+I+ +++vfe+++++ +V+Ey+  G    dL+dy+s 
   mKIAA4088   124 R-EIEIMSSLNHPHIIAIHEVFENSSKIVIVMEYASRG----DLYDYIS- 167  

                   trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldengv
                     ++ +l  se++a+++++Qi+++l Y+H+ngi+HRDLK+eNILld ng+
   mKIAA4088   168 --ERPRL--SERDARHFFRQIVSALHYCHQNGIVHRDLKLENILLDANGN 213  

                   vdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkvD
                   +    KiaDFGl+ +  ++++  l+tf+G+p Y++PE+++g ++ g++vD
   mKIAA4088   214 I----KIADFGLSNL--YhKGKfLQTFCGSPLYASPEIVNGKPYVGPEVD 257  

                   vWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewdsi
                    WSlGv+ly+l+ G  PF+g+     d++ l+++i  + ++++       
   mKIAA4088   258 SWSLGVLLYILVHGTMPFDGQ-----DHKTLVKQISNGAYREPPK----- 297  

                   srsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-*
                              +++a+ Li+++L ++P++R t e++  H w+   
   mKIAA4088   298 -----------PSDACGLIRWLLMVNPTRRATLEDVASHWWV    328  

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