hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data11/genetics/InterProScan/iprscan/data/Pfam Sequence file: /cdna4/rodent/full/goal/mbg/mbg09432/w3open/interpro/cnk_1/seq.in - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: mKIAA4062 ( 1285 res) mbg09432 Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- FH2 Formin Homology 2 Domain 544.6 6.7e-160 1 Drf_GBD Diaphanous GTPase-binding Domain 293.4 2.8e-84 1 Drf_FH3 Diaphanous FH3 Domain 243.5 2.9e-69 1 Drf_FH1 Formin Homology Region 1 190.0 3.8e-53 1 Drf_DAD DRF Autoregulatory Domain 31.6 1.9e-05 1 ERM Ezrin/radixin/moesin family -186.7 0.076 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Drf_GBD 1/1 105 290 .. 1 322 [] 293.4 2.8e-84 Drf_FH3 1/1 295 487 .. 1 234 [] 243.5 2.9e-69 Drf_FH1 1/1 619 777 .. 1 159 [] 190.0 3.8e-53 ERM 1/1 466 903 .. 1 390 [] -186.7 0.076 FH2 1/1 783 1159 .. 1 413 [] 544.6 6.7e-160 Drf_DAD 1/1 1210 1224 .. 1 15 [] 31.6 1.9e-05 Alignments of top-scoring domains: Drf_GBD: domain 1 of 1, from 105 to 290: score 293.4, E = 2.8e-84 *->lqmpsdeeLVdelFeellkedriflnLpedKreaLrnlsaekKWeli lq++sde++ ++lFe++l d +nL+e+K+++Lr++++ +K+e++ mKIAA4062 105 LQDISDEQV-LVLFEQML-VD---MNLNEEKQQPLREKDIVIKREMV 146 cqylskndkgkkkksskselnekaiaSdileilteesspqeYiekLrsga qyl++ ++g+++k+s++ s+++Yi++Lrsg+ mKIAA4062 147 SQYLHTSKAGMNQKESSR-------------------SAMMYIQELRSGL 177 lsekllscsssskehsaknkslgslSpstkvvddgLkvaelesLrVaLrt ++++llsc lesLrV+L++ mKIAA4062 178 RDMHLLSC--------------------------------LESLRVSLNN 195 npvsWVkaFgklgNkGliaLlkiLqtllkkkiyelestdsvesgvekskk npvsWV++Fg + Gl +Ll+iL++l+++k+++ mKIAA4062 196 NPVSWVQTFGAE---GLASLLDILKRLHDEKEET---------------- 226 dspssedlskasprpsPqqnssqesksqqtlkllsqlsaqaqqlqkqqlq mKIAA4062 - -------------------------------------------------- - qsttliektlpsidkklqfecirClKaLMNnklGlkrvLsheesividtl ++++d+++q+e+irClKa+MNnk+G+k++L++ee i++l mKIAA4062 227 ---------SGNYDSRNQHEIIRCLKAFMNNKFGIKTMLETEEG--ILLL 265 vlsLdssnlktrklaleLLaalClv<-* v+++d+ ++++++a++LL+alC++ mKIAA4062 266 VRAMDPAVPNMMIDAAKLLSALCIL 290 Drf_FH3: domain 1 of 1, from 295 to 487: score 243.5, E = 2.9e-69 *->gGhelvleaiinfkevcdereRFrtlvsaldsfssgeedasleykva ++ e+vlea+++ +e+ de+eRF++l ++l+ + s+ +kv mKIAA4062 295 DMNERVLEAMTERAEM-DEVERFQPLLDGLK------SGTSIALKVG 334 tmqFINalvvagnspedlqfRlhLRsEftelGLdeyleklkntssesdkL ++q+INal+ + +e+l+fR+h+RsE+++lGL+++l++l+++ e++++ mKIAA4062 335 CLQLINALI---TPAEELDFRVHIRSELMRLGLHQVLQELREI--ENEDM 379 ddqIklFeenmidvrellddantktkvledleeleerleelkesfaetsv ++q+++F+e+ + ed+ +l +rl++++ + mKIAA4062 380 KVQLCVFDEQ----GD------------EDFFDLKGRLDDIR-------M 406 eldslssvaellsnllkltgaedlllSilQhllllakdseeskLtsyikl e+d+ +v++ + n +k+++ae+++lSilQhlll+++d +e + ++y+kl mKIAA4062 407 EMDDFGEVFQIILNTVKDSKAEPHFLSILQHLLLVRND-YEAR-PQYYKL 454 leeivqqIllhrtkpsdpkfeqklqenvdegterlld<-* +ee+v+qI+lh+ + dp+f+++ ++++++erl+d mKIAA4062 455 IEECVSQIVLHKN-GTDPDFKCR---HLQIDIERLVD 487 Drf_FH1: domain 1 of 1, from 619 to 777: score 190.0, E = 3.8e-53 *->PPpPPLPGvaiPPpPPlppgvaiPPpPPLPGGvgipPpPpLpGdaai PPpPPLPG+++PP+PPlppg++iPPpPPLPGG++ipPpP+LpG+aai mKIAA4062 619 PPPPPLPGGVVPPSPPLPPGTCIPPPPPLPGGACIPPPPQLPGSAAI 665 PPPPPLPgvagiPpPppLPGavaiPPPPPLPGaagiPPPPPLPGgagiiP PPPPPLPgva+iPpPppLPGa+aiPPPPPLPGa++iPPPPPLPGg+gi+P mKIAA4062 666 PPPPPLPGVASIPPPPPLPGATAIPPPPPLPGATAIPPPPPLPGGTGIPP 715 PPPaLPGevaipPPPPLpgGmgviPPaPPlPGaagiPPPPlgpgipPPps PPP+LPG+v++pPPPPLpgG+g++PP+PP+PGa+giPPPP+g+g+pPPp+ mKIAA4062 716 PPPPLPGSVGVPPPPPLPGGPGLPPPPPPFPGAPGIPPPPPGMGVPPPPP 765 fgvgvstlPalP<-* fg+gv+++P+lP mKIAA4062 766 FGFGVPAAPVLP 777 ERM: domain 1 of 1, from 466 to 903: score -186.7, E = 0.076 *->NKKGTdLWLGVDALGLNIYekdDrLTPKIGFPWSEIRNISFnDKKFv K+GTd mKIAA4062 466 -KNGTD----------------------------------------- 470 IKPiDKKApdFvFYaprlRINKRILaLCmGNHELYMRRRKPDTIEVQQMK pdF mKIAA4062 471 --------PDF--------------------------------------- 473 aQArEEKalKqaERekLerEkkaREiaekekEeaEreqqEleerlkqmeE k R + q ++e++ qm mKIAA4062 474 ---------------------KCR-----------HLQIDIERLVDQMID 491 dmrraqkeLeeseekaleLeeklkqeqeaaqkLekkqkeleeenrrLeee ++ + e se ka eLe kl e a+ +L++ e++ ++ e+ mKIAA4062 492 KT-----KVEKSEAKATELEKKLDSELTARHELQV---EMKKMENDFEQK 533 aaaseeErerLeaevdeataevakleeerekkeeEteqlqaelreaqeke + +E++ L e +ta+++ le e+ k + E+++l +el++a+ mKIAA4062 534 LQDLQGEKDALDSEKQQITAQKQDLEAEVSKLTGEVAKLSKELEDAKN-- 581 eeakeellevlaap.................................... ++++l +v ap+ +++ ++ ++ ++++++ ++++++++ +++ mKIAA4062 582 --EMASLSAVVVAPsvsssaavppapplpgdsgtvipppppppplpggvv 629 .................................................. +++++ ++++ +++++ +++ +++++ +++ +++++ ++ + ++ mKIAA4062 630 ppspplppgtcippppplpggacippppqlpgsaaippppplpgvasipp 679 .................................................. +++ ++ + +++++ ++ + +++++ +++++ ++++++ +++ + +++ mKIAA4062 680 ppplpgataippppplpgataippppplpggtgipppppplpgsvgvppp 729 .................................................. ++ +++++ ++++++ ++ ++ ++++++ + +++++ + + + + + + mKIAA4062 730 pplpggpglppppppfpgapgipppppgmgvpppppfgfgvpaapvlpfg 779 .................................................t ++++ +++ + ++++ ++ ++ +++ ++ ++++ ++++ + t mKIAA4062 780 ltpkkvykpevqlrrpnwskfvaedlsqdcfwtkvkedrfennelfaklT 829 appmhhvsapeaELttdngeqleqddngeeasadlePkEFiLtdedmkdr + sa+ + +++ d++g+e+ + + +k mKIAA4062 830 LAF----SAQ------TKTSKAKKDQEGGEEKKSVQ-------KKKVKEL 862 snEiEeeRvteaeknerlqtqLkaLksELaavrdesKetanDil.HeENs ++ +++ q +L L + r + e n il+ +E+ mKIAA4062 863 ----------KVLDSKTAQ----NLSIFLGSFRMPYQEIKNVILeVNEA- 897 vRaGrDKYkTLRqIRkGNTKqRVDqFEsM<-* v EsM mKIAA4062 898 VLT-----------------------ESM 903 FH2: domain 1 of 1, from 783 to 1159: score 544.6, E = 6.7e-160 *->kkepkpkkkLKpLhWdKlnpsqdrgtsvWdkldeesfekkldldlse kk++kp++ L++ +W+K +++ +++++W+k++e++fe+ ++ +++ mKIAA4062 783 KKVYKPEVQLRRPNWSKFVAEDLSQDCFWTKVKEDRFEN--NELFAK 827 lEelFsakakkkkekks....seksskskkkkkeisvLDpkrsQNiaIlL l Fsa++k++k+kk++++++ek+s++kkk+ke++vLD+k++QN++I+L mKIAA4062 828 LTLAFSAQTKTSKAKKDqeggEEKKSVQKKKVKELKVLDSKTAQNLSIFL 877 rklsklppeeivqAilemDedvLgvvlflkemldllenLlkmaPtkeElk +++ ++p++ei++ ile++e vL + +++nL+k +P++e lk mKIAA4062 878 GSF-RMPYQEIKNVILEVNEAVLT--------ESMIQNLIKQMPEPEQLK 918 klqekeykgdekspskLgraEqqFLlelskliprleeRlrallFkstFee +l +e+k++ +++L++ E qF + +prl++Rl+a+lFk++F+e mKIAA4062 919 ML--SELKEE---YDDLAESE-QFGVVMGT-VPRLRPRLNAILFKLQFSE 961 eveelkpsletleaAseeLreSrkfkklLeliLalGNyMNsGtrrrGnAk +ve++kp + ++aA+eeLr+S++f++lLel L +GNyMN+G+r+ ++A+ mKIAA4062 962 QVENIKPEIVSVTAACEELRKSENFSSLLELTLLVGNYMNAGSRN-AGAF 1010 GFkLssLlKLsdvKstidnktTLLHflvkeieesEGkrlEeyrKLklpel GF++s+L+KL d+Ks+ d+k+TLLHfl++++e+ +pe+ mKIAA4062 1011 GFNISFLCKLRDTKSA-DQKMTLLHFLAELCEN------------DHPEV 1047 ldfsseLshVekAakvdleeLeadvkeLekglkklekelelseeSkvsde l+f++eL+hVekA++v+ e+L++ +++++k++ ++e+++++++ + mKIAA4062 1048 LKFPDELAHVEKASRVSAENLQKSLDQMKKQIADVERDVQNFPA----AT 1093 epsdkFvevmkeFleeAeekldkLesllkeakelfkelteYFghggedpk ++ dkFve+m++F+++A+e++ kL+ +++++ +l+kel +YF +dpk mKIAA4062 1094 DEKDKFVEKMTSFVKDAQEQYNKLRMMHSNMETLYKELGDYF---VFDPK 1140 detspeeFFkilrdFlnefk<-* + s eeFF++l++F+n+f mKIAA4062 1141 -KLSVEEFFMDLHNFRNMFL 1159 Drf_DAD: domain 1 of 1, from 1210 to 1224: score 31.6, E = 1.9e-05 *->GvmDsLLEALqsGaA<-* GvmDsLLEALqsGaA mKIAA4062 1210 GVMDSLLEALQSGAA 1224 //