hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mbg/mbg16808/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA4060  ( 1035 res)   mbg16808

Scores for sequence family classification (score includes all domains):
Model           Description                             Score    E-value  N 
--------        -----------                             -----    ------- ---
ADAM_spacer1    ADAM-TS Spacer 1                        160.2    3.6e-44   1
Pep_M12B_propep Reprolysin family propeptide             94.8    1.8e-24   1
TSP_1           Thrombospondin type 1 domain             74.1    2.8e-18   4
Reprolysin      Reprolysin (M12B) family zinc metallo     9.5    6.1e-13   1
Dickkopf_N      Dickkopf N-terminal cysteine-rich reg   -10.1       0.93   1

Parsed for domains:
Model           Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
--------        ------- ----- -----    ----- -----      -----  -------
Pep_M12B_propep   1/1      62   177 ..     1   119 []    94.8  1.8e-24
Reprolysin        1/1     209   411 ..     1   203 []     9.5  6.1e-13
Dickkopf_N        1/1     452   493 ..     1    54 []   -10.1     0.93
TSP_1             1/4     506   556 ..     1    55 []    43.6  4.3e-09
ADAM_spacer1      1/1     664   778 ..     1   128 []   160.2  3.6e-44
TSP_1             2/4     797   854 ..     1    55 []    13.5   0.0098
TSP_1             3/4     859   916 ..     1    55 []    10.2    0.024
TSP_1             4/4     918   969 ..     1    55 []    30.7  3.3e-05

Alignments of top-scoring domains:
Pep_M12B_propep: domain 1 of 1, from 62 to 177: score 94.8, E = 1.8e-24
                   *->hLeknrsllapdftvttYdedGtlvteepliqddHCyYqGyVeGyp.
                      +L++n +l+ap+ tv +++e+G +++e++l+    C Y G V++ p+
   mKIAA4060    62    RLRPNARLVAPGATVEWQGETGDTRVEPLLGS---CLYVGDVADLPk 105  

                   nSaVslSTCsGgLRGilqlenlsYgIEPlessdgfeHiiYqienlkteps
                    S+V+lS C+G L G++++e+++++IEPle +++   +    +++ +  +
   mKIAA4060   106 ASSVALSNCDG-LAGLIRMEEEEFFIEPLEKGQTDQEAEQGRVHVVYRRP 154  

                   pcgecgslstsadssygirsass<-*
                   p+ ++ + s+ + ++ g+        
   mKIAA4060   155 PTPKPPPVSEPQALDTGVSQGNL    177  

Reprolysin: domain 1 of 1, from 209 to 411: score 9.5, E = 6.1e-13
                   *->rYiELvIVvDhgmytkygsdlnkirqrVhqivNlvNeiYrpq...LN
                        iE+ + vD  +++ +g   +++ ++ + ++N+vNeiY +++ + +
   mKIAA4060   209    --IEVLLGVDDSVVQFHG--KEHVQKYLLTLMNIVNEIYHDEslgAH 251  

                   IrVvLvgLEIWsd...gDkInvqsdandTLhsFgeWRetdLlkrks....
                   I VvLv + + s+ +++ +I++ +++++ L++  +W   +L  +k+++++
   mKIAA4060   252 INVVLVRIILLSHaksMSLIEI-GNPSQSLENVCRW--AYLQ-QKPdtdh 297  

                   ...HDnAqLLtgidfd..gntiGaAyvggmCspkrSvGVv.qdhspivll
                   ++ HD+A+ Lt  df+++g ++G A+v gmC+p rS+  +++d+    ++
   mKIAA4060   298 deyHDHAIFLTRQDFGpsG-MQGYAPVTGMCHPVRSCTLNhEDG----FS 342  

                   vAvtMAHELGHNLGmtHDdkntdgCtCe..gggsCIMnpvassspskKkF
                    A ++AHE GH LGm+HD+  +    C+++   + IM+p +    +   F
   mKIAA4060   343 SAFVVAHETGHVLGMEHDGQGN---RCGdeVRLGSIMAP-LVQAAFH-RF 387  

                   ..SnCSkddyqkFltkqkpqCLlNkP<-*
                   + S+CS+ ++ ++l++++  CL + P   
   mKIAA4060   388 hwSRCSQQELSRYLHSYD--CLRDDP    411  

Dickkopf_N: domain 1 of 1, from 452 to 493: score -10.1, E = 0.93
                   *->eCisDeDCgtdeYChssrqgkslvClpCRkrrkrCtRDamCCpgnlC
                      +C        +  C+ + +  +     C++++   +   mC pg +C
   mKIAA4060   452    PCK-------QLWCSHPDN--P---YFCKTKKGPPLDGTMCAPGKHC 486  

                   vNGiCtp<-*
                     G+C+    
   mKIAA4060   487 FKGHCIW    493  

TSP_1: domain 1 of 4, from 506 to 556: score 43.6, E = 4.3e-09
                   *->spWseWSpCSVTCGkGirtRqRvcnspaPqkkggepCtgdvqelete
                      + W++  +CS TCG G++ R+R c++p P   gg  C g + +  ++
   mKIAA4060   506    GAWTPFGSCSRTCGTGVKFRTRQCDNPHPA-NGGRTCSGLAYD--FQ 549  

                   aCdmmdkC<-*
                    C + + C   
   mKIAA4060   550 LC-NPQDC    556  

ADAM_spacer1: domain 1 of 1, from 664 to 778: score 160.2, E = 3.6e-44
                   *->ktvkGtFtkaslgaGYndVvtIPaGArhIlIrElkkSgqrnddnyLA
                      k+vkGtFt+ +++  Y+++++IPaGArh lI+E+   +     ++L 
   mKIAA4060   664    KVVKGTFTRSPRKQDYIKMFEIPAGARHLLIQEADTTS-----HHLS 705  

                   LknsdTGskyiLNGnwtisapgrtfelaGTvfeYsrisddvsntapEsLt
                   +kn  TG+ +iLN ++++++ +r f ++G+++eY+  +d+      E+L+
   mKIAA4060   706 VKNLETGK-FILNEENHLDPNSRSFIAMGVEWEYRN-EDE-----RETLQ 748  

                   atGPtnepLivqvLfqggapnpgikYeYtiP<-*
                   + GP++ +++v+v++  g+++ +++Y+Y+i+   
   mKIAA4060   749 TIGPLHGTITVLVIPE-GDTRISLTYKYMIH    778  

TSP_1: domain 2 of 4, from 797 to 854: score 13.5, E = 0.0098
                   *->spWse..WSpCSVTCGkGir.....tRqRvcnspaPqkkggepCtgd
                       +W  ++WSpCS++CG+G++ ++ + R+R++ +++      ++C   
   mKIAA4060   797    HEWALkkWSPCSKPCGGGSQftkygCRRRLDSKMV----HRAFCSAL 839  

                   vqe.leteaCdmmdkC<-*
                   + ++   +aC + ++C   
   mKIAA4060   840 AKPkAIRRAC-NPQEC    854  

TSP_1: domain 3 of 4, from 859 to 916: score 10.2, E = 0.024
                   *->spWseWSpCSVTCG.kGirtRqRvcnspaPqkkgg.......epCtg
                       +++eW+pC+ +CG+ G+++R  +c +p    +++++++ ++++C +
   mKIAA4060   859    WVTGEWEPCTQSCGrTGMQVRSVRCIQPL---HNNttrsvhtKHCND 902  

                   dvqeleteaCdmmdkC<-*
                      e   +aC + + C   
   mKIAA4060   903 HRPE-SRRAC-NRELC    916  

TSP_1: domain 4 of 4, from 918 to 969: score 30.7, E = 3.3e-05
                   *->spW..seWSpCSVTCGkGirtRqRvcnspaPqkkggepCtgdvqele
                      + W+ + WS+CSVTCG+G+++R  +c       ++ + C ++  e  
   mKIAA4060   918    GRWraGSWSQCSVTCGNGTQERPVLCRTAD---DNFGVCREERPE-T 960  

                   teaCdmmdkC<-*
                    ++C +  +C   
   mKIAA4060   961 ARIC-RLAPC    969  

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