hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mbg/mbg06182/w3open/interpro/cnk_1/seq.in
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query:  mKIAA4048  ( 1363 res)   mbg06182

Scores for sequence family classification (score includes all domains):
Model      Description                                  Score    E-value  N 
--------   -----------                                  -----    ------- ---
PDZ        PDZ domain (Also known as DHR or GLGF)       165.2    1.1e-45   4
Extensin_2 Extensin-like region                        -138.5       0.45   1

Parsed for domains:
Model      Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
--------   ------- ----- -----    ----- -----      -----  -------
PDZ          1/4     254   338 ..     1    82 []    73.0  6.2e-18
PDZ          2/4     393   476 ..     1    82 []    21.9     0.01
Extensin_2   1/1     455   879 ..     1   385 []  -138.5     0.45
PDZ          3/4    1147  1230 ..     1    82 []    44.9  1.8e-09
PDZ          4/4    1267  1348 ..     1    82 []    30.8  3.3e-05

Alignments of top-scoring domains:
PDZ: domain 1 of 4, from 254 to 338: score 73.0, E = 6.2e-18
                   *->evtlekevkrgglGfsikggsdk.....givvsevlpGsgaAeagGr
                       ++l+k+ +  glGfsi+gg+d   ++ gi+v+++ +G gaA+a+Gr
   mKIAA4048   254    NIVLMKG-QAKGLGFSIVGGKDSiygpiGIYVKSIFAG-GAAAADGR 298  

                   LkeGDqIlsvNGqdvenlsheravlalkgsggsevtLtil<-*
                   L+eGD  l++NG+++++l+h +a +  k+++++ +tLt++   
   mKIAA4048   299 LQEGDESLELNGESMAGLTHQDALQKFKQAKKGLLTLTVR    338  

PDZ: domain 2 of 4, from 393 to 476: score 21.9, E = 0.01
                   *->evtlekevkrgglGfsikggsdk....givvsevlpGsgaAeagGrL
                      ev+l+ke  + glG+ + +    +  +gi+v  ++pG + A+ +GrL
   mKIAA4048   393    EVSLKKE-AGVGLGIGLCSIPYFqcisGIFVHTLSPG-SVAHLDGRL 437  

                   keGDqIlsvNGqdvenlsheravlalkgsgg.sevtLtil<-*
                   + GD I+++N+ +v  l++ ++  +l  + ++++v + +    
   mKIAA4048   438 RCGDEIVEINDSPVHCLTLNEVYTILSHC-DpGPVPIIVS    476  

Extensin_2: domain 1 of 1, from 455 to 879: score -138.5, E = 0.45
                   *->lltlvvalvslslpseasakYsYsSPPPpekpY..............
                      +l  v +++s + p +     + + P P+    + ++   +  ++ +
   mKIAA4048   455    TLNEVYTILSHCDPGPVP-IIVSRHPDPQVSEQqlkeavaqavegvk 500  

                   ..................vYkSPPpPspkyvykSPPPpkkpY........
                    ++++++ + ++ ++ ++ ++  P    +   +S PP ++  +   ++++
   mKIAA4048   501 fgkdrhqwslegvkrlesSWHGRPTLEKEREKHSAPPHRRAQkimvrsss 550  

                   ..vYsSPPPPsyvykSPPPPkpyvYkSPPpPkyvYkSPPpPv...ykYkS
                   ++ Y S  P      SP           P+P+    S  +P+ ++   + 
   mKIAA4048   551 dsSYMSGSPG----GSPCSA-----GAEPQPSEREGSTHSPSlspGEEQE 591  

                   PPPPthsppPpyvykSPPPPpkkyvykSpPpptPvYkYkSPPPPpyvYks
                   P P +   p ++  +SPP P+ +    S Pp   +  +      p   k 
   mKIAA4048   592 PCPGV---PSRPQQESPPLPE-SLERESHPPLRLKKSFEILVRKPTSSKP 637  

                   pPpPvkkripyvYkSPPPPpP.YvYkSpPppvkkyiyksppppephkYvY
                    PpP k    ++  S P    + + k   p      +  p+  ++     
   mKIAA4048   638 KPPPRKY---FKNDSEPQKKLeEKEKVTDPSG----HTLPTCSQET---- 676  

                   kSPPPPpPYvyesvpeqkikYvYkSPPPPkksYk.spsppkyVYkSpPpP
                   +   P      ++    + +      P P  s ++s s      +S+ p 
   mKIAA4048   677 RELLPLL---LQEDTAGRAPCTAACCPGPAASTQtSSSTEGESRRSASPE 723  

                   vipykYkSPPPPkkkyspaPrkpyvYkSPPPPtyvYkSpPpPykpptppk
                   ++     SP    +  +   r  y +      + v  S    +   ++  
   mKIAA4048   724 TP----ASPGKH-PLLKRQARMDYSFDITAEDPWVRISDCIKNLFSPIMS 768  

                   iyksPPPPtP...........................vyvYkspPpippi
                      s  P  P+++ ++++++++ ++++ ++ +  ++ + vYks+     +
   mKIAA4048   769 ENHSHTPLQPntslgeedgtqgcpegglskmdaangaPRVYKSADG-STV 817  

                   k...sssppPvyvYkSpPppvysPPPPyvYssPPPPvyvynsaPvykksP
                   k++++  p+P+   +S        P P   + PP  +   + +Pv +++P
   mKIAA4048   818 KkgpPVAPKPAWFRQSLKGLRNRAPDP---RRPPEVASAIQPTPVSRDPP 864  

                   PkhhYiYsSPPPphh<-*
                    +++   sS         
   mKIAA4048   865 GPQPQASSSIRQRIS    879  

PDZ: domain 3 of 4, from 1147 to 1230: score 44.9, E = 1.8e-09
                   *->evtlekevkrgglGfsikggsdk...givvsevlpGsgaAeagGrLk
                       ++l+ke ++ glGfs++gg d +++ i v +v p+ g A + G ++
   mKIAA4048  1147    VTILHKE-EGAGLGFSLAGGADLenkVITVHRVFPN-GLASQEGTIQ 1191 

                   eGDqIlsvNGqdvenlsheravlalkgsgg.sevtLtil<-*
                   +G  +ls+NG+++ + +h +a ++l++++++++  ++ +   
   mKIAA4048  1192 KGNEVLSINGKSLKGATHNDALAILRQARDpRQAVIVTR    1230 

PDZ: domain 4 of 4, from 1267 to 1348: score 30.8, E = 3.3e-05
                   *->evtlekevkrgglGfsikggsdk.....givvsevlpGsgaAeagGr
                      +vtlek  +  glGfs+ gg+   ++++++ ++++ +G    e+g  
   mKIAA4048  1267    TVTLEK--TSAGLGFSLEGGKGSlhgdkPLTINRIFKG---TEQGEM 1308 

                   LkeGDqIlsvNGqdvenlsheravlalkgsggsevtLtil<-*
                    ++GD Il++ G+ v +l+  +a  ++k  ++++vt++i+   
   mKIAA4048  1309 VQPGDEILQLAGTAVQGLTRFEAWNVIKALPDGPVTIVIR    1348 

//