hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data11/genetics/InterProScan/iprscan/data/Pfam Sequence file: /cdna4/rodent/full/goal/mpf/mpf01333/w3open/interpro/cnk_1/seq.in - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: mKIAA4041 ( 1671 res) mpf01333 Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- 7tm_2 7 transmembrane receptor (Secretin fa 347.1 1.9e-100 1 Laminin_G_2 Laminin G domain 208.0 1.4e-58 2 EGF EGF-like domain 122.6 7.2e-33 6 HRM Hormone receptor domain 71.2 2.2e-17 1 Laminin_G_1 Laminin G domain 68.6 1.3e-16 2 GPS Latrophilin/CL-1-like GPS domain 63.4 4.7e-15 1 Laminin_EGF Laminin EGF-like (Domains III and V) 18.1 0.0023 2 TNFR_c6 TNFR/NGFR cysteine-rich region 13.5 0.21 1 Metallothio_PEC Plant PEC family metallothionein -27.4 0.52 1 Dicty_CAR Slime mold cyclic AMP receptor -257.0 0.056 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- EGF 1/6 15 46 .. 1 39 [] 32.9 7.2e-06 EGF 2/6 55 88 .. 1 39 [] 34.0 3.6e-06 Laminin_G_2 1/2 118 277 .. 1 141 [] 122.1 1e-32 Laminin_G_1 1/2 118 280 .. 1 154 [] 59.0 1e-13 EGF 3/6 301 332 .. 1 39 [] 38.0 2.1e-07 Laminin_G_2 2/2 367 497 .. 1 141 [] 87.3 3.2e-22 Laminin_G_1 2/2 367 500 .. 1 154 [] 10.8 0.0012 EGF 4/6 524 555 .. 1 39 [] 29.4 8.5e-05 EGF 5/6 559 593 .. 1 39 [] 32.2 1.2e-05 Metallothio_PEC 1/1 517 595 .. 1 80 [] -27.4 0.52 Laminin_EGF 1/2 564 616 .. 1 59 [] -17.4 8.1 TNFR_c6 1/1 635 670 .. 1 42 [] 13.5 0.21 EGF 6/6 648 681 .. 1 39 [] -3.8 44 Laminin_EGF 2/2 651 696 .. 1 59 [] 43.5 4.7e-09 HRM 1/1 700 757 .. 1 76 [] 71.2 2.2e-17 GPS 1/1 1055 1108 .. 1 55 [] 63.4 4.7e-15 7tm_2 1/1 1113 1356 .. 1 296 [] 347.1 1.9e-100 Dicty_CAR 1/1 1111 1483 .. 1 465 [] -257.0 0.056 Alignments of top-scoring domains: EGF: domain 1 of 6, from 15 to 46: score 32.9, E = 7.2e-06 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* C +n pC +G+C++ +ggytCeC + +tG++C mKIAA4041 15 CYSN--PCGANGRCRSREGGYTCECFED-----FTGEHC 46 EGF: domain 2 of 6, from 55 to 88: score 34.0, E = 3.6e-06 *->CspnngpCsngGtCvdtpg.gytCeCppGdyfllytGkrC<-* C++ C+ngGtCv++ +g++C CppG +y ++C mKIAA4041 55 CASG--VCKNGGTCVNLLIgGFHCVCPPG----EYEHPYC 88 Laminin_G_2: domain 1 of 2, from 118 to 277: score 122.1, E = 1e-32 *->FRTatqpnGlLlyaggk.glpdtadpksdKflaLeLvdGrlvlrydl F T + n+lLly+g + k+d f+aLe+v+ +l+l+++ mKIAA4041 118 FAT-QDRNALLLYNGRFnE-------KHD-FIALEIVEEQLQLTFSA 155 G.sgg.vlltsg.klnDGqWHtVsverngrs................vtL G+++++v+ ++ ++DG+WH+V v + ++ + ++ + ++++++++ +++ mKIAA4041 156 GeTTTtVTPQVPgGVSDGRWHSVLVQYYNKPnighlglphgpsgekvAVV 205 sVDgg.vv.g.spgssdtl..............slnlngplylGGlpess +VD+++++ + gs +++ + +++++++++sl+l+gpl lGG+p+ + mKIAA4041 206 TVDDCdAAvAvHFGSYVGNyscaaqgtqsgskkSLDLTGPLLLGGVPNLP 255 ksslltltaaqnlvvvs.gFvGCirdvringe<-* + +++ s+ FvGC+r++ i+g+ mKIAA4041 256 EDFPVH----------SrQFVGCMRNLSIDGR 277 Laminin_G_1: domain 1 of 2, from 118 to 280: score 59.0, E = 1e-13 *->FRTtepsGlLllgYnGtntdrrgkkeigdDFlaleLvdGrlevsydl F+T + ++lLl YnG +++ DF+ale+v +l+++++ mKIAA4041 118 FATQDRNALLL--YNGRFNEKH-------DFIALEIVEEQLQLTFSA 155 GsghrlrpavvrsgdrvlnDGkWHrvelerng................rk G + + +v+ + ++DG+WH+v + + ++++ ++ + ++++++++ mKIAA4041 156 GET---TTTVTPQVPGGVSDGRWHSVLVQYYNkpnighlglphgpsgeKV 202 gtLsVdgeer...............vvdgespsgpditsenLdldtppiL +++ Vd+++ + ++ ++ + ++g++ ++++ Ldl++p L mKIAA4041 203 AVVTVDDCDAavavhfgsyvgnyscAAQGTQSGSKKS----LDLTGP--L 246 yvGGlPelqksvkrrlaaistsFkGCirdvsingkpld<-* +GG P + ++s++F+GC+r++si+g+ +d mKIAA4041 247 LLGGVP----NLPEDFPVHSRQFVGCMRNLSIDGRIVD 280 EGF: domain 3 of 6, from 301 to 332: score 38.0, E = 2.1e-07 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* C+ + C+ngGtCv+ +++y CeCp + Gk+C mKIAA4041 301 CDGT--SCQNGGTCVNRWNTYLCECPLR-----FGGKNC 332 Laminin_G_2: domain 2 of 2, from 367 to 497: score 87.3, E = 3.2e-22 *->FRTatqpnGlLlyaggk.glpdtadpksdKflaLeLvdGrlvlrydl FRT ++++G+L+ a +++ l+L++ + ++++++++ mKIAA4041 367 FRT-RKEDGVLMEATAGtS---------S-RLHLQILNSYIRFEVSY 402 G.sgg.vlltsg.klnDGqWHtVsverngrs........vtLsVDgg.vv G+s+ + +s++++ DG WH++ +e + +++++ + +++++D+g + mKIAA4041 403 GpSDVaSMQLSKsRITDGGWHHLLIELRSAKegkdikylAVMTLDYGmDQ 452 .g.spgssdtlslnlngp.lylGGlpessksslltltaaqnlvvvs.gFv ++ + g++ + l+ +++ +GG+ e+ s ++gF+ mKIAA4041 453 sTvQIGNQ---LPGLKMRtIVIGGVTEDKVSV-------------RhGFR 486 GCirdvringe<-* GC+++vr++ mKIAA4041 487 GCMQGVRMGET 497 Laminin_G_1: domain 2 of 2, from 367 to 500: score 10.8, E = 0.0012 *->FRTtepsGlLllgYnGtntdrrgkkeigdDFlaleLvdGrl..evsy FRT++++G+L+ + +Gt + l++ + ++ evsy mKIAA4041 367 FRTRKEDGVLMEATAGTSSRL-----------HLQILNSYIrfEVSY 402 dlGsghrlrpavvrsgdrvlnDGkWHrveler........ngrkgtLsVd ++ + + s+ r ++DG WH++ +e ++ +++++++ +++ +d mKIAA4041 403 GPSDV----ASMQLSKSR-ITDGGWHHLLIELrsakegkdIKYLAVMTLD 447 .geervvdgespsgpditsenLdldtppiLyvGGlPelqksvkrrlaais g + + +g+ ++ L+++t + +GG + + ++ mKIAA4041 448 yGMDQ---STVQIGNQLPG--LKMRT---IVIGGVT-------EDKVSVR 482 tsFkGCirdvsingkpld<-* ++F+GC++ v++++ + mKIAA4041 483 HGFRGCMQGVRMGETSTN 500 EGF: domain 4 of 6, from 524 to 555: score 29.4, E = 8.5e-05 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* C++ pC + C+dt+++y+C+C+ G y Gk+C mKIAA4041 524 CASS--PCPPHSHCRDTWDSYSCICDRG-----YFGKKC 555 EGF: domain 5 of 6, from 559 to 593: score 32.2, E = 1.2e-05 *->CspnngpCsngGtCvdtpg...gytCeCppGdyfllytGkrC<-* C n pC++ + Cv++p++++gy+CeC pG G +C mKIAA4041 559 CLLN--PCKHVAACVRSPNtprGYSCECGPG-----HYGQYC 593 Metallothio_PEC: domain 1 of 1, from 517 to 595: score -27.4, E = 0.52 *->gCDDkCGCp.sPCPGGkaCRCtsggaaeAsaGdqEHttCpCGEHCGC gCD C++sPCP CR t + d++ C C mKIAA4041 517 GCDVEDPCAsSPCPPHSHCRDTWD--SYSCICDRGYFGKKCVDACLL 561 NPC....tCpksetptgrkgrRAnCsCGagCtCasCAS<-* NPC++ +C +s + + C CG+g C mKIAA4041 562 NPCkhvaACVRSPNTPRGYS----CECGPGHYGQYCEN 595 Laminin_EGF: domain 1 of 2, from 564 to 616: score -17.4, E = 8.1 *->CdCnphGslsddtCdsddelf..geetGqClkCkpnvtGrrCdr... C h + C + ++++ ++ C C p+ +G+ C+ + + mKIAA4041 564 CK---HV----AACVR----SpnTPRGYSCE-CGPGHYGQYCENkvd 598 ..CkpGyyglpsgdpgqgC<-* +C G +g+p ++p+ C mKIAA4041 599 lpCPKGWWGNPVCGPC-HC 616 TNFR_c6: domain 1 of 1, from 635 to 670: score 13.5, E = 0.21 *->CeegvtYtdenhvpqClsCskCepemGqvlvspCtatqnT.vC<-* C+e+ +Y +++ + Cl+C C p +G+ +++ C++ +T++C mKIAA4041 635 CKEN-YYKPPAQ-DACLPCD-CFP-HGS-HSRACDM--DTgQC 670 EGF: domain 6 of 6, from 648 to 681: score -3.8, E = 44 *->CspnngpCsngGtCvdtpg..gytCeCppGdyfllytGkrC<-* C p C +G + + ++ +C C+pG G++C mKIAA4041 648 CLPC--DCFPHGSHSRACDmdTGQCACKPG-----VIGRQC 681 Laminin_EGF: domain 2 of 2, from 651 to 696: score 43.5, E = 4.7e-09 *->CdCnphGslsddtCdsddelfgeetGqClkCkpnvtGrrCdrCkpGy CdC phGs+s Cd tGqC Ckp+v Gr+C+rC + mKIAA4041 651 CDCFPHGSHS-RACDM-------DTGQCA-CKPGVIGRQCNRCDNPF 688 yglpsgdpgqgC<-* ++ gC mKIAA4041 689 AEV---TSL-GC 696 HRM: domain 1 of 1, from 700 to 757: score 71.2, E = 2.2e-17 *->glgCpatwDgivCWPrtpaGqlvvvpCPdyfsGfnydttgedfgnay ++gCp+ ++ +++WP+t++Gq+++vpCP++ G na mKIAA4041 700 YNGCPRAFEAGIWWPQTKFGQPAAVPCPKGSVG-----------NAV 735 RnCtenGwwerhpsnwpwpnysaCtsney<-* R+C + +w +p +++Cts + mKIAA4041 736 RHCSGEKGWL-------PPELFNCTSGSF 757 GPS: domain 1 of 1, from 1055 to 1108: score 63.4, E = 4.7e-15 *->tnpiCvfWdessl.estgvWstdrGCevveenkpshttCsCnHLTtF ++p CvfW++s +++tg+Ws+ GCe++ +n +h+tC+C+H ++ mKIAA4041 1055 SKPVCVFWNHSLDtGGTGGWSA-KGCELLSRNR-THVTCQCSHSASC 1099 Avlmdvppn<-* Avlmd +++ mKIAA4041 1100 AVLMDISRR 1108 7tm_2: domain 1 of 1, from 1113 to 1356: score 347.1, E = 1.9e-100 *->lllLkviytVGyslSSLvaLllAiaifllfRkLhCtRnyIHlNLfas l Lk+i+++ +slS LvaLl+A+++++l+R L+++ + IH+NL+a+ mKIAA4041 1113 VLPLKIITYAALSLS-LVALLVAFVLLSLVRTLRSNLHSIHKNLIAA 1158 fiLralsfLikdavlfnsvglseadqlsweeslhcsasagkitmivvVgC ++ ++l+f++++++++n++ C mKIAA4041 1159 LFFSQLIFMVGINQTENPFL-----------------------------C 1179 kvvavflhYfflaNFfWmLVEGlYLhtllvvtvevffserkrfwwYlliG +vva++lhY + +F+W LVE l+ +++l +ev++ +++ +++Y+++G mKIAA4041 1180 TVVAILLHYVSMGTFAWTLVENLHVYRML---TEVRNIDTGPMRFYHVVG 1226 WGvPavfvgiwaivrpdkwagygnegCCWlsnedngyfwWiikGPvllvI WG+Pa+++g++++++p+ gygn+++CWls+ ++ ++W+++GPv +vI mKIAA4041 1227 WGIPAIVTGLAVGLDPQ---GYGNPDFCWLSL--QDTLIWSFAGPVGTVI 1271 lvNfilFinilriLvqKlridkslspqmgetdqyrkkrlakstLlLlPLL ++N ++F++ +++ +q+++ +++ + ++ + ++++++lLl+L+ mKIAA4041 1272 IINTVIFVLSAKVSCQRKH------HYYERKGVVS---MLRTAFLLLLLV 1312 GitwvlflfapeddsqGvssivflylfliLnSfQGffVavlYCFlNgEV< tw+l+l+a+++d + f+ylf+ ++++QG+fV +++C++++EV mKIAA4041 1313 TATWLLGLLAVNSD-----TLSFHYLFAAFSCLQGIFVLLFHCVAHREV 1356 -* mKIAA4041 - - Dicty_CAR: domain 1 of 1, from 1111 to 1483: score -257.0, E = 0.056 *->mmtkqeidlsysvLLiADFsSIiGCllVLIGFWRLKLLR....NHiT +++++ + +y+ L + ++ L++F L L R+ ++N mKIAA4041 1111 GEVLPLKIITYAALSLS-------LVALLVAFVLLSLVRtlrsN--- 1147 kvIacFCaTSllKDliStiL..TLtekPqneasnggFpCYLYAIVITYGS + S K li + L+ +++ F C AI Y S mKIAA4041 1148 -------LHSIHKNLIAALFfsQLIFMVGINQTENPFLCTVVAILLHYVS 1190 LACWLWTLCLafSIYnLI..VkR.EPEPEkfEKyYfllCWglPLIstIvM + WTL + +Y + ++V+ P +f Y+++ Wg+P I t mKIAA4041 1191 MGTFAWTLVENLHVYRMLteVRNiDTGPMRF---YHVVGWGIPAIVT--G 1235 LsKkt.iefvGN..WCWIGekYvGYRFGLFY...GPFfaIWgiSAvLVGL L+ +++ + GN++ CW + + + L+ + GP + +i v L mKIAA4041 1236 LAVGLdPQGYGNpdFCWLSLQDT-----LIWsfaGPVGTVIIINTVIFVL 1280 TSrYTYsVIrnsVSDNKDKHmTYQFKLINYII..VFLvCWVFAvvNRIlN + VS KH Y K + ++ FL+ v l mKIAA4041 1281 SAK---------VSCQR-KHHYYERKGVVSMLrtAFLL--LLLVTATWLL 1318 GLnmFPtapNiLHTYLSVSHGFYASVTFIYNNPLMWRYfGsKiLliFtkF GL + + LS H +A + ++ l+F mKIAA4041 1319 GL------LAVNSDTLSF-HYLFAAFS----------CLQGIFVLLF--- 1348 GyFV...etqkRLEkNKNNNNPSPissSrgatdnkldsnstgdhnnnhnn +V ++e+ k L ++ + + ld + t mKIAA4041 1349 -HCVahrEVRKHLRA---------VLAGKKLQ---LDDSAT--------- 1376 hnnnnnnnnsdfvnndssdvycsSeiESlSldaeNnidipngadNlnqnq + + Sl N ++g d l++ mKIAA4041 1377 ---------------------TRATLLTRSLNCNNT--YSEGPDMLRTAL 1403 alqqdvkqqfqqqqsptvie.mqnlkqdqnienneqnencyntidtniei + s t e++q l + e i n + mKIAA4041 1404 GESTASL------DSTTRDEgVQKLSVSSGPARGNHGEPDTSFIPRNSKK 1447 itndedsssselsssdnekntvennNnynnnnnNnnaNn<-* +s sels ++ + + +++ + + mKIAA4041 1448 AHGPDSDSDSELSL---DEHSSSYASSHTSDSEDDGGEA 1483 //