hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/smart.HMMs
Sequence file:            /cdna4/rodent/full/goal/mic/mic20095/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA4040  ( 1035 res)   mic20095

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
RasGEF   Guanine nucleotide exchange factor for Ras-l   363.4   1.4e-104   1
cNMP     Cyclic nucleotide-monophosphate binding doma   129.6    3.5e-34   2
DEP      Domain found in Dishevelled, Egl-10, and Ple   105.2    7.7e-27   1
RasGEFN  Guanine nucleotide exchange factor for Ras-l    39.4    4.9e-07   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
cNMP       1/2      67   186 ..     1   123 []    64.7  1.2e-14
DEP        1/1     240   315 ..     1    90 []   105.2  7.7e-27
cNMP       2/2     380   499 ..     1   123 []    64.9    1e-14
RasGEFN    1/1     519   654 ..     1   172 []    39.4  4.9e-07
RasGEF     1/1     792  1034 ..     1   261 []   363.4 1.4e-104

Alignments of top-scoring domains:
cNMP: domain 1 of 2, from 67 to 186: score 64.7, E = 1.2e-14
                   *->lfkaldaeelreladalepvrypaGevifrqGdpgdsfYiivsGeve
                       f+  ++ +lr+++ + + + +++G ++frqGd g+++Y +++G+++
   mKIAA4040    67    AFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLD 113  

                   vyktrlstledgreqilatlgpGdfFGElallrrarsaaavalvelatll
                   v +   +t ++ + ++++tlg G  FGE  l +++r+a++v++ e ++ll
   mKIAA4040   114 VKVS--ETSSHQDAVTICTLGIGTAFGESILDNTPRHATIVTR-ESSELL 160  

                   ridferflqllpenpqlllelllell<-*
                   ri+ e+f  l ++++q ++ ll+  +   
   mKIAA4040   161 RIEQEDFKALWEKYRQYMAGLLAPPY    186  

DEP: domain 1 of 1, from 240 to 315: score 105.2, E = 7.7e-27
                   *->pesglklddrkyflktypncFtGselVdWLldnlegqsnngptkttf
                       + +  ++drky+lkty++c++G+elVdW++++++           +
   mKIAA4040   240    SRAPHMIRDRKYHLKTYRQCCVGTELVDWMIQQTS-----------C 275  

                   iidreeAvhlgqaLlkeGlihhvndpnkhtFkdsknalYrFtd<-*
                   +++r++Av ++q+Ll+ G++ hv+   +++F+d+ + +YrF d   
   mKIAA4040   276 VHSRTQAVGMWQVLLEDGVLNHVD--QERHFQDK-YLFYRFLD    315  

cNMP: domain 2 of 2, from 380 to 499: score 64.9, E = 1e-14
                   *->lfkaldaeelreladalep.vrypaGevifrqGdpgdsfYiivsGev
                       +++l+    rela +l  + + + G+v+f qG+ g+s+Yii++G+v
   mKIAA4040   380    ALSHLSTTVKRELAGVLIFeSHAKGGTVLFNQGEEGTSWYIILKGSV 426  

                   evyktrlstledgreqilatlgpGdfFGElall....rrarsaaavalve
                    v+          +  +++tl+ Gd FG lal+++ +r+a  +  + +++
   mKIAA4040   427 NVVIY--------GKGVVCTLHEGDDFGKLALVndapRAASIVLREDNCH 468  

                   latllridferflqllpenpqlllelllell<-*
                   + ++++ df+r+l+ +++n  +l+e+ +  l   
   mKIAA4040   469 FLRVDKEDFNRILRDVEANTVRLKEHDQDVL    499  

RasGEFN: domain 1 of 1, from 519 to 654: score 39.4, E = 4.9e-07
                   *->ckggliKgGtlekLiehLteardkgkvdlkaDptfvetFLlTYRsFi
                      ++++++++Gt+ek++eh +e+   +     a ++ +++F +++ +F+
   mKIAA4040   519    QQKYTVMSGTPEKILEHFLETIRLEPSLNEATDSVLNDFVMMHCVFM 565  

                   ttqeLlqkLldrYnaippeivsrSlelkateaseglsfedy.sknaipvg
                   + ++L+ +L+++Y a p++             +  ++  dy + n     
   mKIAA4040   566 PNTQLCPALVAHYHAQPSQ-------------GTEQERMDYaLNN----- 597  

                   faetdiivkekvnprriqnrVlnilrlWvenywedFeedpklnlfLeelf
                                    ++rV++++++W + y     ed+   +fLee f
   mKIAA4040   598 -----------------KRRVIRLVLQWAAMYGDLLQEDDVAMAFLEE-F 629  

                   lelvedkkdkgpglekslanilerls<-*
                   +  v d++  +++ +k+ +  le+++   
   mKIAA4040   630 YVSVSDDA-RMMAAFKEQLPELEKIV    654  

RasGEF: domain 1 of 1, from 792 to 1034: score 363.4, E = 1.4e-104
                   *->lllldpeelAeQLTlldfelFrkIepsEllgsvwgkrskkspsplap
                      + l+++++lA Q+T  d+elF+++++ El+++++g++++k  ++   
   mKIAA4040   792    FELMSSKDLAYQMTTYDWELFNCVHELELIYHTFGRHNFKKTTA--- 835  

                   qnleafierfNevsnwVateIlkqttlkpkkRaevlskFIkVAkhcreLn
                    nl++f +rfNe+++wV+te++++ +  ++kR+++l+kFIk+A+hc+e++
   mKIAA4040   836 -NLDLFLRRFNEIQFWVVTEVCLCSQ--LSKRVQLLKKFIKIAAHCKEYK 882  

                   NFnSlmAIvsaLssspIsRLkkTWeklsskykklfeeLeelldpserNfk
                   N+nS++AIv++Ls+ ++sRL++TWekl+sk+kk++ e e+l+dps rN++
   mKIAA4040   883 NLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPS-RNHR 931  

                   nYReaLkscnkspnvqppcvPflGvyLkDLtfidegnpdflengtkglvN
                   +YR + ++++      pp +Pf+++++kD+tf++egn++f++    +lvN
   mKIAA4040   932 AYRLTAAKLE------PPLIPFMPLLIKDMTFTHEGNKTFID----NLVN 971  

                   FeKrrkiakilreirqlqsacqpynlkpnr.....ndiqellrasrplev
                   FeK+r+ia++ r++r+++s  qp n+++ + +++++d++++ r+   l+v
   mKIAA4040   972 FEKMRMIANTARTVRYYRS--QPFNPDAAQanknhQDVRSYVRQ---LNV 1016 

                   lpeeedelyelSlriEPrv<-*
                   ++++  +l ++S+r+EPr    
   mKIAA4040  1017 IDNQR-TLSQMSHRLEPRR    1034 

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