hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mic/mic20095/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA4040  ( 1035 res)   mic20095

Scores for sequence family classification (score includes all domains):
Model        Description                                Score    E-value  N 
--------     -----------                                -----    ------- ---
RasGEF       RasGEF domain                              174.8    1.4e-48   1
cNMP_binding Cyclic nucleotide-binding domain           135.0    1.3e-36   2
DEP          Domain found in Dishevelled, Egl-10, and   109.5    6.4e-29   1
RA           Ras association (RalGDS/AF-6) domain        41.8    1.6e-08   1
RasGEF_N     Guanine nucleotide exchange factor for R    24.8     0.0021   1

Parsed for domains:
Model        Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
--------     ------- ----- -----    ----- -----      -----  -------
cNMP_binding   1/2      83   176 ..     1   100 []    66.3  6.3e-16
DEP            1/1     240   313 ..     1    80 []   109.5  6.4e-29
cNMP_binding   2/2     397   486 ..     1   100 []    68.7  1.2e-16
RasGEF_N       1/1     518   580 ..     1    66 []    24.8   0.0021
RA             1/1     692   771 ..     1    98 []    41.8  1.6e-08
RasGEF         1/1     793   977 ..     1   227 []   174.8  1.4e-48

Alignments of top-scoring domains:
cNMP_binding: domain 1 of 2, from 83 to 176: score 66.3, E = 6.3e-16
                   *->lelrsfkkGevifreGdpadslYivlsGkvkvyk.dedgreq..ilg
                      ++ ++++kG ++fr+Gd ++ +Y vl G++ v +++ +  +   +++
   mKIAA4040    83    GYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVsETSSHQDavTIC 129  

                   ilgpGdffGelallggendspSrhaprsatvvAltdsellvipredflel
                   +lg G  fGe ++l+++        pr+at+v+++ sell+i++edf++l
   mKIAA4040   130 TLGIGTAFGE-SILDNT--------PRHATIVTRESSELLRIEQEDFKAL 170  

                   leedpe<-*
                   +e++ +   
   mKIAA4040   171 WEKYRQ    176  

DEP: domain 1 of 1, from 240 to 313: score 109.5, E = 6.4e-29
                   *->pesgvklkdrkwlkkvipncFtGselVdWLmdnlsgiidrkeAlhla
                       + +++++drk+++k++++c++G+elVdW+++ +s++++r +A++++
   mKIAA4040   240    SRAPHMIRDRKYHLKTYRQCCVGTELVDWMIQQTSCVHSRTQAVGMW 286  

                   qlLlkeGyirhvgdhltgkndhtFldkqtyYrf<-*
                   q+Ll+ G++ hv      +++++F+dk+ +Yrf   
   mKIAA4040   287 QVLLEDGVLNHV------DQERHFQDKYLFYRF    313  

cNMP_binding: domain 2 of 2, from 397 to 486: score 68.7, E = 1.2e-16
                   *->lelrsfkkGevifreGdpadslYivlsGkvkvyk.dedgreqilgil
                      + + + k G+v+f +G++++s+Yi+l+G+v v+  +++     +++l
   mKIAA4040   397    IFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIyGKGV----VCTL 439  

                   gpGdffGelallggendspSrhaprsatvvA.ltdsellvipredflell
                   ++Gd fG lal+++         pr+a++v ++++++ l++++edf+++l
   mKIAA4040   440 HEGDDFGKLALVNDA--------PRAASIVLrEDNCHFLRVDKEDFNRIL 481  

                   eedpe<-*
                   ++  +   
   mKIAA4040   482 RDVEA    486  

RasGEF_N: domain 1 of 1, from 518 to 580: score 24.8, E = 0.0021
                   *->ydkvgsikggtleNiaLieyLvET.RiDALtdlesedlnFvetFLlt
                       ++++++++gt e  +++e+ +ET R++  ++l  + ++  ++F  +
   mKIAA4040   518    PQQKYTVMSGTPE--KILEHFLETiRLE--PSLNEATDSVLNDFVMM 560  

                   YrsFittqelldlLikrYnl<-*
                   + +F++ ++l+ +L+++Y     
   mKIAA4040   561 HCVFMPNTQLCPALVAHYHA    580  

RA: domain 1 of 1, from 692 to 771: score 41.8, E = 1.6e-08
                   *->dsgvlrVygedgtpgtyktilvskntTaeeViralLrKfgldaddpe
                      d+   +Vy+ d+t   y+ti+v+   +++eVi a+++K+g      +
   mKIAA4040   692    DEVLFKVYCIDHT---YTTIRVPVAASVKEVISAVADKLGS-----G 730  

                   dyvLvEvslvlerggeerrvLpddEkPlqiqlqlkrdaqvrsrFlLrrre
                   +  +++    +++gge   vL +++  +   l+       ++r++ + re
   mKIAA4040   731 EGLIIV---KMNSGGEKV-VLKSNDVSVFTTLTI------NGRLFACPRE 770  

                   d<-*
                   +   
   mKIAA4040   771 Q    771  

RasGEF: domain 1 of 1, from 793 to 977: score 174.8, E = 1.4e-48
                   *->LllDplelAkQLTLlEhelfkkItpfefLgsKmKHEGPqvWgkksfk
                      +l ++ +lA Q+T  + elf  +   e+ +         + g+  fk
   mKIAA4040   793    ELMSSKDLAYQMTTYDWELFNCVHELELIY--------HTFGRHNFK 831  

                   gkeerspnidktiknfNqltnfvsetIlkqeFPTNPEFSKkvdpkkRaev
                   +      n+d++ ++fN+ + +v +++ +               +kR+++
   mKIAA4040   832 KTT---ANLDLFLRRFNEIQFWVVTEVCLCS-----------QLSKRVQL 867  

                   iqkfIqVAdhcReLnNFnSllaIisALysspIyRLkkTWekvppqslklI
                   ++kfI +A hc+e++N+nS +aI+ +L++ +++RL +TWek+p++ +k+ 
   mKIAA4040   868 LKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKF- 916  

                   feeLnkLmdsdrNfsnyRelLksigplappnLdddfvraPCVPFfGvYLs
                     e + Lmd++rN++ yR +  +  p             P +PF +++++
   mKIAA4040   917 YAEFESLMDPSRNHRAYRLTAAKLEP-------------PLIPFMPLLIK 953  

                   DLtfleeGnpdyleekKINtnlvNFsKrrk<-*
                   D tf++eGn+++        nlvNF+K+r+   
   mKIAA4040   954 DMTFTHEGNKTFID------NLVNFEKMRM    977  

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