hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/smart.HMMs
Sequence file:            /cdna4/rodent/full/goal/mfj/mfj00669/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA4037  ( 919 res)   mfj00669

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
RhoGEF   Guanine nucleotide exchange factor for Rho/R   238.5    5.7e-67   1
BRCT     breast cancer carboxy-terminal domain           99.6    3.6e-25   2

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
BRCT       1/2     180   256 ..     1    93 []    50.3  2.5e-10
BRCT       2/2     274   350 ..     1    93 []    49.5  4.4e-10
RhoGEF     1/1     462   646 ..     1   211 []   238.5  5.7e-67

Alignments of top-scoring domains:
BRCT: domain 1 of 2, from 180 to 256: score 50.3, E = 2.5e-10
                   *->sklfkgltfvltGddiegkfd.e.rdelkeliealGGkvt.svsrkk
                         +  l+ ++t     g   +e++ +l  l++ +GG + ++     
   mKIAA4037   180    TSMLN-LVLCFT-----GFRKkEeLVKLVTLVHHMGGVIRkE----- 215  

                   l.pttthviv.spegkkletdnrsstkllkaialgipiVteeWlldclkk
                   +++ +th++++ + g+k+            a++lg+pi+++eW+++ +++
   mKIAA4037   216 CnSKVTHLVAnCTQGEKFR----------VAVSLGTPIMKPEWIYKAWER 255  

                   g<-*
                   +   
   mKIAA4037   256 R    256  

BRCT: domain 2 of 2, from 274 to 350: score 49.5, E = 4.4e-10
                   *->sklfkgltfvltGddiegkfd.e.rdelkeliealGGkvt.svsrkk
                      +++f+++  ++ G      f++e+++ ++e+ e+ GG +++  ++  
   mKIAA4037   274    VPPFQDCILSFLG------FSdEeKHSMEEMTEMQGGSYLpVGDE-- 312  

                   lpttthviv.spegkkletdnrsstkllkaialgipiVteeWlldclkkg
                     ++th+iv+++  k l              + ++ +V+ eW++ ++++ 
   mKIAA4037   313 --RCTHLIVeENTVKDLP----------FEPSKKLFVVKQEWFWGSIQMD 350  

                   <-*
                      
   mKIAA4037     -     -    

RhoGEF: domain 1 of 1, from 462 to 646: score 238.5, E = 5.7e-67
                   *->vlkELlqTErnYVrdLkilvevflkpLkkeakssllpllspdevktl
                      v+kEL+qTE nYV+ L ++++ f+ pL++e+++++ p+l p+e+kt+
   mKIAA4037   462    VAKELYQTESNYVNILATIIQLFQVPLEEEGQRGG-PILAPEEIKTI 507  

                   FgpNieeiyefHrrFLdeLeerveewllskdlKsernsviedsgerigdv
                   Fg  i++i+++H++  d+Le+ +++w               d +  igd+
   mKIAA4037   508 FG-SIPDIFDVHMKIKDDLEDLIANW---------------DESRSIGDI 541  

                   FlklfsaeeffkiYseYcsnhpdalellkkLmkkkknpaFqkflkeiesk
                   Flk+  a+++ k+Y ++++ +++++e+++k  + k++p+F++flk +++k
   mKIAA4037   542 FLKY--AKDLVKTYPPFVNFFEMSKEMIIK--CEKQKPRFHAFLKINQAK 587  

                   pncrsksearltLeslLikPvQRltkYpLLLkellkhtppdhedredLkk
                   p+c+     r++L +lLi PvQRl+   LLL++l kht ++ +d+  L+k
   mKIAA4037   588 PECG-----RQSLVELLIRPVQRLPSVALLLNDLKKHTADENPDKSTLEK 632  

                   AleaikelasqvNe<-*
                   A++++ke+++++Ne   
   mKIAA4037   633 AIGSLKEVMTHINE    646  

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