hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mfj/mfj00669/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA4037  ( 919 res)   mfj00669

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
RhoGEF   RhoGEF domain                                  155.0    1.3e-42   1
BRCT     BRCA1 C Terminus (BRCT) domain                  84.3    2.5e-21   2
PH       PH domain                                       23.2     0.0063   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
BRCT       1/2     177   253 ..     1    96 []    30.1  5.1e-05
BRCT       2/2     272   347 ..     1    96 []    54.7  2.1e-12
RhoGEF     1/1     462   646 ..     1   207 []   155.0  1.3e-42
PH         1/1     673   798 ..     1    92 []    23.2   0.0063

Alignments of top-scoring domains:
BRCT: domain 1 of 2, from 177 to 253: score 30.1, E = 5.1e-05
                   *->p.eklfkgltfyltggldgfereeleleelieklGGkvtsslskktt
                        ++ + +l++++tg   ++e  +l    l+  +GG + ++ ++k+t
   mKIAA4037   177    LyCTSMLNLVLCFTGFRKKEELVKL--VTLVHHMGGVIRKECNSKVT 221  

                   hvislvgepkypkieiifigsleagtskkllkakalgipivteeWlldci
                   h++  +                ++ ++k ++ a +lg pi+++eW+++ +
   mKIAA4037   222 HLV--AN---------------CTQGEK-FRVAVSLGTPIMKPEWIYKAW 253  

                   <-*
                      
   mKIAA4037     -     -    

BRCT: domain 2 of 2, from 272 to 347: score 54.7, E = 2.1e-12
                   *->p.eklfkgltfyltggldgfereeleleelieklGGkvtsslskktt
                      ++ ++f+++++++  g++++e+  +  ee+ e+ GG++ +  ++++t
   mKIAA4037   272    FkVPPFQDCILSF-LGFSDEEKHSM--EEMTEMQGGSYLPVGDERCT 315  

                   hvislvgepkypkieiifigsleagtskkllkakalgipivteeWlldci
                   h+i  v+e+               + +  l   +++++ +v+ eW++ +i
   mKIAA4037   316 HLI--VEEN---------------TVKD-LPFEPSKKLFVVKQEWFWGSI 347  

                   <-*
                      
   mKIAA4037     -     -    

RhoGEF: domain 1 of 1, from 462 to 646: score 155.0, E = 1.3e-42
                   *->vlkElleTEkkYvrdLeildnvymkpLreaaisskpvltpddietiF
                      v+kEl++TE++Yv+ L ++++ +  pL e+     p+l p++i+tiF
   mKIAA4037   462    VAKELYQTESNYVNILATIIQLFQVPLEEEGQRGGPILAPEEIKTIF 508  

                   sNiediyefhreFLkssLearisssqfedlDekkiepsaqrlGdlFlklk
                   + i+di ++h  + +  Le+ i  +           ++ + +Gd+Flk+ 
   mKIAA4037   509 GSIPDIFDVHMKIKD-DLEDLIANW-----------DESRSIGDIFLKYA 546  

                   epflqvYgeYcsnkpyAqelleklrqaasnpqFaefldeveassntgAkd
                   ++  + Y+++++ ++ ++e+++k  + ++ p F  fl+  +a++ +g   
   mKIAA4037   547 KDLVKTYPPFVNFFEMSKEMIIK--CEKQKPRFHAFLKINQAKPECG--- 591  

                   davkltLqsLLlkPvqRilrYpLLLkeLLkhtpegedqpdredLkkaldl
                      + +L  LL+ PvqR++   LLL++L+kht    + pd+  L+ka++ 
   mKIAA4037   592 ---RQSLVELLIRPVQRLPSVALLLNDLKKHTAD--ENPDKSTLEKAIGS 636  

                   lqdlaksiNe<-*
                   l++++++iNe   
   mKIAA4037   637 LKEVMTHINE    646  

PH: domain 1 of 1, from 673 to 798: score 23.2, E = 0.0063
                   *->vikeGwLlkkg.......gkkswkkRyfvLfndvLlyykdkk.....
                        ++  +++ ++ + +++ + + +++ ++Lfnd+L++ +++++  ++
   mKIAA4037   673    SSHRSLVQRVEtvslgehPCDRGEQVTLFLFNDCLEIARKRHkvigt 719  

                   .............kkpkgsipLsgi.qvekvpdn.krkncFeirt.dr..
                    ++++++++++ + k+++ +pLs+i++v ++ ++++ +n+F +  + +++
   mKIAA4037   720 frsphdrtrppasLKHIHLMPLSQIkKVLDIRETeDCHNAFALLVrPPte 769  

                   ...etlllqaese.eerkeWvkaiqsair<-*
                   + +  l +q +se+  +++W+k+++++++   
   mKIAA4037   770 qanVLLSFQMTSEeLPKESWLKMLCRHVA    798  

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