hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/smart.HMMs
Sequence file:            /cdna4/rodent/full/goal/mpm/mpm03294/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA3023  ( 1305 res)   mpm03294

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
TyrKc    Tyrosine kinase, catalytic domain              436.2   1.8e-126   1
S_TKc    Serine/Threonine protein kinases, catalytic    156.0    3.9e-42   1
FU       Furin-like repeats                              92.5    5.1e-23   4

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
FU         1/4     239   280 ..     1    48 []     4.3       33
FU         2/4     282   325 ..     1    48 []    37.5  1.8e-06
FU         3/4     551   600 ..     1    48 []    32.6  5.3e-05
FU         4/4     607   656 ..     1    48 []    42.2    7e-08
TyrKc      1/1     770  1026 ..     1   280 []   436.2 1.8e-126
S_TKc      1/1     770  1027 ..     1   231 []   156.0  3.9e-42

Alignments of top-scoring domains:
FU: domain 1 of 4, from 239 to 280: score 4.3, E = 33
                   *->dgvCkpChpsCat.GCtGpgadqCtsCkhgyyldgngtCvseCppgt
                      ++ C+pC p+C++++C+G  +++C+       l g  +C s C    
   mKIAA3023   239    SRACPPCAPTCKDnHCWGESPEDCQ------ILTG-TICTSGCARCK 278  

                   ya<-*
                    +   
   mKIAA3023   279 GR    280  

FU: domain 2 of 4, from 282 to 325: score 37.5, E = 1.8e-06
                   *->dgvCkpChpsCatGCtGpgadqCtsCkhgyyldgngtCvseCp.pgt
                       + C  Ch++Ca GCtGp+  +C++C h+++    g+C   Cp   t
   mKIAA3023   282    PTDC--CHEQCAAGCTGPKHSDCLACLHFNHS---GICELHCPaLIT 323  

                   ya<-*
                   y    
   mKIAA3023   324 YN    325  

FU: domain 3 of 4, from 551 to 600: score 32.6, E = 5.3e-05
                   *->dgvC....kpChpsCat.GCtGpgadqCtsCkhgyyldgngtCvseC
                      +  C+ ++  C++ Ca ++C+Gpg++qC+ C+ ++ +++   Cv+eC
   mKIAA3023   551    EEACglegLVCNSLCARgHCWGPGPTQCVNCSQFLRGQE---CVEEC 594  

                   ppgtya<-*
                     +      
   mKIAA3023   595 RVWKGL    600  

FU: domain 4 of 4, from 607 to 656: score 42.2, E = 7e-08
                   *->dgvCkpChpsCat.....GCtGpgadqCtsCkhgyyldgngtCvseC
                      +++C pChp+C  ++++++C+G+ adqC +C+h+++    + Cv+ C
   mKIAA3023   607    GKHCLPCHPECQPqnsseTCYGSEADQCEACAHYKDS---SSCVARC 650  

                   ppgtya<-*
                   p+g  +   
   mKIAA3023   651 PSGVKP    656  

TyrKc: domain 1 of 1, from 770 to 1026: score 436.2, E = 1.8e-126
                   *->ltlgkkLGeGaFGeVykGtlk.......ieVAVKtLkeda....kee
                      l+++k+LG+GaFG+VykG++++++++ +i+VA+K+L+e+++++  +e
   mKIAA3023   770    LRKLKVLGSGAFGTVYKGIWIpdgenvkIPVAIKVLRENTspkaNKE 816  

                   FlrEakiMkklGgkHpNiVkLlGvcteegrrFmevePlmivmEymegGdL
                   +l+Ea +M  +    p + +LlG+c++          + +v+ +m++G+L
   mKIAA3023   817 ILDEAYVMAGV--GSPYVSRLLGICLT--------STVQLVTQLMPYGCL 856  

                   ldyLrknrpklslsdLlsfAlQIAkGMeYLesknfvHRDLAARNcLvgen
                   ld+ r++r++l  +dLl++++QIAkGM+YLe+ ++vHRDLAARN+Lv+++
   mKIAA3023   857 LDHVREHRGRLGSQDLLNWCVQIAKGMSYLEEVRLVHRDLAARNVLVKSP 906  

                   kvvKIsDFGLsRdlyddDkkGeskdyYrkkggkggktllPirWmAPEslk
                   ++vKI+DFGL+R l+ d      +  Y++    ggk  +Pi+WmA+Es+ 
   mKIAA3023   907 NHVKITDFGLARLLDID------ETEYHAD---GGK--VPIKWMALESIL 945  

                   dgkFtskSDVWSFGVlLWEiftlGeqPYpgeiqqfmsneevleylkkGyR
                    ++Ft++SDVWS+GV+ WE++t+G++PY g     ++++e+  +l+kG+R
   mKIAA3023   946 RRRFTHQSDVWSYGVTVWELMTFGAKPYDG-----IPAREIPDLLEKGER 990  

                   lpkPendlpiSsvtCPdelYdlMlqCWaedPedRPtFselverl<-*
                   lp+P+         C+ ++Y++M +CW+ d e+RP+F+elv+++   
   mKIAA3023   991 LPQPPI--------CTIDVYMIMVKCWMIDSECRPRFRELVSEF    1026 

S_TKc: domain 1 of 1, from 770 to 1027: score 156.0, E = 3.9e-42
                   *->YellkklGkGaFGkVylardkk....tgrlvAiKvik........er
                       ++lk+lG+GaFG+Vy+++++ ++++ +  vAiKv++++++++ ++ 
   mKIAA3023   770    LRKLKVLGSGAFGTVYKGIWIPdgenVKIPVAIKVLRentspkanKE 816  

                   ilrEikiLkk.dHPNIVkLydvfeddklylVmEyceGdlGdLfdllkkrg
                   il E  ++   + P++ +L++++ ++ + lV+ +++   G L+d+ ++++
   mKIAA3023   817 ILDEAYVMAGvGSPYVSRLLGICLTSTVQLVTQLMPY--GCLLDHVREHR 864  

                   rrglrkvlsE.earfyfrQilsaLeYLHsqgIiHRDLKPeNiLLds..hv
                   +r     l  ++   ++ Qi++++ YL + + +HRDL   N+L+ s++hv
   mKIAA3023   865 GR-----LGSqDLLNWCVQIAKGMSYLEEVRLVHRDLAARNVLVKSpnHV 909  

                   KlaDFGlArql.........ttfvGTpeYmAPEvl...gYgkpavDiWSl
                   K++DFGlAr+l+ ++++ + +   +   +mA E + ++ +++  +D+WS 
   mKIAA3023   910 KITDFGLARLLdideteyhaDGGKVPIKWMALESIlrrRFTH-QSDVWSY 958  

                   GcilyEllt.GkpPFp.....qldlifkkig........SpeakdLikkl
                   G++++El+t G  P+++ + +++  +++k  + + ++  + ++  ++ k+
   mKIAA3023   959 GVTVWELMTfGAKPYDgiparEIPDLLEKGErlpqppicTIDVYMIMVKC 1008 

                   LvkdPekRlta.eaLedeldikaHPff<-*
                   +  d e R+  +e+          +f    
   mKIAA3023  1009 WMIDSECRPRFrELVS--------EFS    1027 

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