hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/smart.HMMs
Sequence file:            /cdna4/rodent/full/goal/mph/mph02030/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA3017  ( 710 res)   mph02030

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
RhoGAP   GTPase-activator protein for Rho-like GTPase   247.5    1.1e-69   1
C2       Protein kinase C conserved region 2 (CalB)      52.6    5.3e-11   1
PH       Pleckstrin homology domain.                     41.7      1e-07   1
RhoGEF   Guanine nucleotide exchange factor for Rho/R    36.8    2.9e-06   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
RhoGEF     1/1       1   129 [.     1   211 []    36.8  2.9e-06
PH         1/1     148   307 ..     1    82 []    41.7    1e-07
C2         1/1     351   456 ..     1    92 []    52.6  5.3e-11
RhoGAP     1/1     504   688 ..     1   193 []   247.5  1.1e-69

Alignments of top-scoring domains:
RhoGEF: domain 1 of 1, from 1 to 129: score 36.8, E = 2.9e-06
                   *->vlkELlqTErnYVrdLkilvevflkpLkkeakssllpllspdevktl
                                                                  + l
   mKIAA3017     1    --------------------------------------------DGL 3    

                   FgpNieeiyefHrrFLdeLeerveewllskdlKsernsviedsgerigdv
                   F+                   rv++w                +++r+gd+
   mKIAA3017     4 FP-------------------RVQQWS---------------HQQRVGDL 19   

                   FlklfsaeeffkiYseYcsnhpdalellkkLmkkkknpaFqkflkeiesk
                   F+kl   ++++ +Y ++++n+  a+e+ +k  +++ n +F++  + + ++
   mKIAA3017    20 FQKL---ASQLGVYRAFVDNYGVAMETAEK--CCQANAQFAEISENLRAR 64   

                   pncrsk.sea.rltLeslLikPvQRltkYpLLLkellkhtppdhedredL
                   +n + k+s  ++ +Le+lL kPv R+t+  L L++llkhtp++h+d+  L
   mKIAA3017    65 SNKDVKdS-TtKNSLETLLYKPVDRVTRSTLVLHDLLKHTPSSHPDHSLL 113  

                   kkAleaikelasqvNe<-*
                   ++Al+++++++s++Ne   
   mKIAA3017   114 QDALRISQNFLSSINE    129  

PH: domain 1 of 1, from 148 to 307: score 41.7, E = 1e-07
                   *->vikeGwLlkksk.swkkryfvLfngvLlyyksk..........kpkg
                      ++k  ++  +  + +k r+ +Lf++ Ll++k k+++++++++ ++k 
   mKIAA3017   148    LLKDSFMVELVEgARKLRHIFLFTDLLLCTKLKkqsggktqqyDCKW 194  

                   sipLsgcsvre.p.....................................
                    ipL+++s+++ ++ +  ++ +  ++++ +  + + +  +++  ++++ +
   mKIAA3017   195 YIPLTDLSFQMvDelealpniplvpdeeldalkikisqiksdiqrekran 244  

                   ...........................cFeivt.dr.tlllqAeseeere
                   ++++  ++ +++ ++ ++     +++ +F++++++++++++  +s+ er 
   mKIAA3017   245 kgskvmerlrkklseqesllllmspsmAFRVHSrNGkSYTFLISSDYERA 294  

                   eWvealqsaiaka<-*
                   eW e++++ ++k+   
   mKIAA3017   295 EWRESIREQQKKC    307  

C2: domain 1 of 1, from 351 to 456: score 52.6, E = 5.3e-11
                   *->tLtvkiisArnLp...DPYVkvs...........kTkvvkktlsgfN
                       L+v ++sA + + +++ Y++++ ++ +   ++ kT+v ++t     
   mKIAA3017   351    FLHVIVHSATGFKqssNLYCTLEvdsfgyfvnkaKTRVYRDTT---E 394  

                   PvWnEesetFeFevpp.s.LeieVyDk................dfiGrvt
                   P WnE   +Fe+e+  +++L+i +y+k  ++ + +++++++ ++++G+ +
   mKIAA3017   395 PNWNE---EFEIELEGsQtLRILCYEKcynkmkmtkedgesadKLMGKGQ 441  

                   ippnnahqhsadglihlsell.ggrh.kl<-*
                   +               l+    ++r+ +    
   mKIAA3017   442 VQ--------------LDPQTlQDRDwQR    456  

RhoGAP: domain 1 of 1, from 504 to 688: score 247.5, E = 1.1e-69
                   *->spiPiivekCieylekrGldteGIYRvsGsksrvkeLreafdsged.
                      s +P iv++C+e++e+rG++++GIYRvsG+++ +++L++afd ++++
   mKIAA3017   504    SKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKd 550  

                   dldsldesiteesedleeydvhdvAglLKlyLReLPePLltfelyeefie
                   +           s++ +e dv+++Ag LKly+ReLPePL+t+e y++f e
   mKIAA3017   551 V-----------SVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAE 589  

                   aaklyqieatsrkqseksedeeerlralrellslLPpanratLryLl.HL
                    + l              +d++++  ++++ll +LP+an+ t+ +Ll+HL
   mKIAA3017   590 GIAL--------------SDPVAKESCMLNLLLSLPEANLLTFLFLLdHL 625  

                   nrVaehsevNkMtarNLAivFgPtLlrpp...............ltdikh
                   +rVae++ vNkM+++NLA+vFgPtLlrp++++++ + +++++ ++td+  
   mKIAA3017   626 KRVAEKETVNKMSLHNLATVFGPTLLRPSekesklpanpsqpitMTDSWS 675  

                   qnkvvetlienad<-*
                     ++ ++++  ++   
   mKIAA3017   676 LEVMSQVQVLLYF    688  

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