hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mph/mph02030/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA3017  ( 710 res)   mph02030

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
RhoGAP   RhoGAP domain                                  247.4      2e-70   1
RhoGEF   RhoGEF domain                                  110.1    4.4e-29   1
C2       C2 domain                                       48.1    1.9e-10   1
PH       PH domain                                       23.0     0.0069   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
RhoGEF     1/1       1   129 [.     1   207 []   110.1  4.4e-29
PH         1/1     148   305 ..     1    92 []    23.0   0.0069
C2         1/1     352   441 ..     1    88 []    48.1  1.9e-10
RhoGAP     1/1     507   660 ..     1   155 []   247.4    2e-70

Alignments of top-scoring domains:
RhoGEF: domain 1 of 1, from 1 to 129: score 110.1, E = 4.4e-29
                   *->vlkElleTEkkYvrdLeildnvymkpLreaaisskpvltpddietiF
                                                                     
   mKIAA3017     -    ----------------------------------------------- -    

                   sNiediyefhreFLkssLearisssqfedlDekkiepsaqrlGdlFlklk
                                 + +L++r++++           +++qr+GdlF+kl 
   mKIAA3017     1 --------------D-GLFPRVQQW-----------SHQQRVGDLFQKL- 23   

                   epflqvYgeYcsnkpyAqelleklrqaasnpqFaefldeveassntgAkd
                   +++l+vY+++++n+++A+e++ek  ++++n+qFae++++++a+sn++ kd
   mKIAA3017    24 ASQLGVYRAFVDNYGVAMETAEK--CCQANAQFAEISENLRARSNKDVKD 71   

                   davkltLqsLLlkPvqRilrYpLLLkeLLkhtpegedqpdredLkkaldl
                    ++k++L++LL+kPv+R++r++L+L++LLkhtp+  ++pd+ +L++al++
   mKIAA3017    72 STTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPS--SHPDHSLLQDALRI 119  

                   lqdlaksiNe<-*
                   +q++++siNe   
   mKIAA3017   120 SQNFLSSINE    129  

PH: domain 1 of 1, from 148 to 305: score 23.0, E = 0.0069
                   *->vikeGwLlkkggkkswkkRyfvLfndvLlyykdkk........kkpk
                      + k  ++      + +k R+++Lf+d Ll+ k kk+++++++++++k
   mKIAA3017   148    LLKDSFMVELV-EGARKLRHIFLFTDLLLCTKLKKqsggktqqYDCK 193  

                   gsipLsgiqvekvpdn..................................
                    +ipL ++++  v++ +  ++ +  ++++ +  + + ++ +++ +++++ 
   mKIAA3017   194 WYIPLTDLSFQMVDELealpniplvpdeeldalkikisqiksdiqrekra 243  

                   ........................krkncFeirt.dretlllqaeseeer
                   +++++  ++ +++ +++++         +F++++++++++++  +s+ er
   mKIAA3017   244 nkgskvmerlrkklseqesllllmSPSMAFRVHSrNGKSYTFLISSDYER 293  

                   keWvkaiqsair<-*
                    eW ++i+++++   
   mKIAA3017   294 AEWRESIREQQK    305  

C2: domain 1 of 1, from 352 to 441: score 48.1, E = 1.9e-10
                   *->LrVtvieAknLppkDfkngksDPYVkvslggdkkd.qkkkTkvikkt
                      L+V v++A + +       +s+ Y++++++  +   +k kT+v ++t
   mKIAA3017   352    LHVIVHSATGFKQ------SSNLYCTLEVDSFGYFvNKAKTRVYRDT 392  

                   lNPvWNEtFtFevpppdlqetLeieVyDydrfgr..........ddflGe
                     P WNE+F++e  ++  q  L+i +y+++  + + +++++++ d+++G+
   mKIAA3017   393 TEPNWNEEFEIE--LEGSQT-LRILCYEKCYNKMkmtkedgesaDKLMGK 439  

                   vs<-*
                    +   
   mKIAA3017   440 GQ    441  

RhoGAP: domain 1 of 1, from 507 to 660: score 247.4, E = 2e-70
                   *->PlivekCieflekrGLdtEGIyRvsGsksrikeLreafdrgedvdln
                      P iv++C+e++e+rG++++GIyRvsG ++ i++L++afd +  ++++
   mKIAA3017   507    PYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSV 553  

                   dleeedvhvvAslLKlFLReLPePLltfelyeefieaaaksedeeerlea
                     +e dv+++A+ LKl++ReLPePL+t+e+y++f e  + + d+ ++ ++
   mKIAA3017   554 MMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAE-GIALSDPVAKESC 602  

                   lrellrkLPpaNrdtLryLlahLnrVaqnsevNkMtahNLAivFgPtLlr
                   +  ll +LP+aN  t+ +Ll hL+rVa+ + vNkM+ hNLA+vFgPtLlr
   mKIAA3017   603 MLNLLLSLPEANLLTFLFLLDHLKRVAEKETVNKMSLHNLATVFGPTLLR 652  

                   ppdgdsad<-*
                   p++++s++   
   mKIAA3017   653 PSEKESKL    660  

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