hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/smart.HMMs
Sequence file:            /cdna4/rodent/full/goal/mbg/mbg07142/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA2016  ( 1731 res)   mbg07142

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
RhoGEF   Guanine nucleotide exchange factor for Rho/R   219.1    3.9e-61   1
RBD      Raf-like Ras-binding domain                    105.6    5.6e-27   1
PH       Pleckstrin homology domain.                     83.9    1.9e-20   2
PDZ      Domain present in PSD-95, Dlg, and ZO-1/2.      39.1    5.8e-07   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
PH         1/2     521   636 ..     1    82 []    68.3  9.7e-16
RBD        1/1     847   918 ..     1    76 []   105.6  5.6e-27
PDZ        1/1     937  1011 ..     1    80 []    39.1  5.8e-07
RhoGEF     1/1    1140  1329 ..     1   211 []   219.1  3.9e-61
PH         2/2    1363  1494 ..     1    82 []    16.6      3.6

Alignments of top-scoring domains:
PH: domain 1 of 2, from 521 to 636: score 68.3, E = 9.7e-16
                   *->vikeGwLlkks..............k.swkkryfvLfngvLlyyksk
                      v k GwL  k   + ++ ++     +++wk+++++L++ +Ll+y+  
   mKIAA2016   521    VRKAGWLFFKPlvtlqkerklelvaRrKWKQYWVTLKGCTLLFYETY 567  

                   .........kpkgsipLsgcsvre.p.......cFeivt.dr.tlllqAe
                   ++++++++++p+  ++ ++ +v+  p++++++++F+++++ ++++l+qA 
   mKIAA2016   568 gknsteqnsAPRCALFAEDSIVQSvPehpkkehVFCLSNsCGdVYLFQAT 617  

                   seeereeWvealqsaiaka<-*
                   s+ ++e Wv+a++sa+a++   
   mKIAA2016   618 SQTDLENWVTAIHSACASL    636  

RBD: domain 1 of 1, from 847 to 918: score 105.6, E = 5.6e-27
                   *->ktcrvhLPdnqrtvVkvRPGktvrDaLakaLkkRgLnpeacvVrlrg
                      ++++vh++dn++++V+++P+++v+D+La+a+k+R+L+p++++++lr+
   mKIAA2016   847    VQTYVHFQDNEGVTVTIKPEHRVEDVLALACKMRQLEPTHYGLQLRK 893  

                   dpqeGekkpldlnqdissLagqElvveel<-*
                   +    ++k++++++++ ++++qE+v++e+   
   mKIAA2016   894 V----VDKSVEWCVPALYEYMQEQVYDEI    918  

PDZ: domain 1 of 1, from 937 to 1011: score 39.1, E = 5.8e-07
                   *->gglGfsivg.........gifvssvvpGspAakaGrkslglLkvGDv
                        +Gf ++ + +++++ + if+s+v+p+s A+  G      L++G +
   mKIAA2016   937    TDFGFAVTVqvdehqhlnRIFISDVLPDSLAYGGG------LRKGNE 977  

                   IleVNGetsvegltheeavdllkkaggggvGekvtLtvlRgg<-*
                   I++ NG ++v++l+ ++  +l  +        +v Lt++ ++   
   mKIAA2016   978 ITSLNG-EPVSDLDIQQMEALFSEK-------SVGLTLVARP    1011 

RhoGEF: domain 1 of 1, from 1140 to 1329: score 219.1, E = 3.9e-61
                   *->vlkELlqTErnYVrdLkilvevflkpLkkeakssllpllspdevktl
                      v++EL++TE++YV+dL +l e +l+pL++e       +l++de+++l
   mKIAA2016  1140    VIQELVDTEKSYVKDLSCLFELYLEPLQNET------FLTQDEMESL 1180 

                   FgpNieeiyefHrrFLdeLeerveewllskdl.Ksernsviedsgerigd
                   Fg  ++e +ef++ FL++Le++++ +    d++  e+ s++++    +g 
   mKIAA2016  1181 FG-SLPEMLEFQKVFLETLEDAISASS---DFsVLETPSQFRKLLFSLGG 1226 

                   vFlklfsaeeffkiYseYcsnhpdalellkkLmkkkknpaFqkflkeies
                    Fl +   +++fk+Ys +c+nh + +++l+    +k+++aF++fl+ +  
   mKIAA2016  1227 SFLYY---ADHFKLYSGFCANHIKVQRVLER---AKTDKAFKAFLDARNP 1270 

                   kpncrsksearltLeslLikPvQRltkYpLLLkellkhtppdhedredLk
                    ++++       tLes+LikPvQR++kYpLLLkel   t++++e++ +L+
   mKIAA2016  1271 TKQHS------STLESYLIKPVQRVLKYPLLLKELVSLTDHESEEHYHLT 1314 

                   kAleaikelasqvNe<-*
                   +Al+a++++as++Ne   
   mKIAA2016  1315 EALKAMEKVASHINE    1329 

PH: domain 2 of 2, from 1363 to 1494: score 16.6, E = 3.6
                   *->vikeGwLlkks........k.swkkryfvLfngvLlyyksk......
                      ++++ +++++ +  + ++ ++      fv+++ v+l yk+  + +++
   mKIAA2016  1363    LLMHSTVSWLNpflslgkaRkDIELTVFVFKRAVILVYKENcklkkk 1409 

                   .................kpkgsipLsgcsvre.p........cFeivt.d
                    ++++++ +++ + ++ k +  ip+s ++vr +   + ++++++e+++++
   mKIAA2016  1410 lpsnsrpahnsadldpfKFRWLIPISALQVRLgNtagtennsTWELIHtK 1459 

                   r........tlllqAeseeereeWvealqsaiaka<-*
                    + ++++++ + l+++++e +++ v+ ++s ++++   
   mKIAA2016  1460 SeiegrpetIFQLCCSDSENKTSIVKVIRSILREN    1494 

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