hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mbg/mbg07142/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA2016  ( 1731 res)   mbg07142

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
RhoGEF   RhoGEF domain                                  149.5      6e-41   1
PH       PH domain                                       80.3    3.9e-20   2
PDZ      PDZ domain (Also known as DHR or GLGF)          33.8      4e-06   1
RBD      Raf-like Ras-binding domain                      1.4       0.97   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
PH         1/2     521   634 ..     1    92 []    78.7  1.2e-19
RBD        1/1     847   918 ..     1    77 []     1.4     0.97
PDZ        1/1     927  1008 ..     1    82 []    33.8    4e-06
RhoGEF     1/1    1140  1329 ..     1   207 []   149.5    6e-41
PH         2/2    1357  1492 ..     1    92 []     2.4       13

Alignments of top-scoring domains:
PH: domain 1 of 2, from 521 to 634: score 78.7, E = 1.2e-19
                   *->vikeGwLlkkg.............gkkswkkRyfvLfndvLlyykdk
                      v k GwL+ k   + +++++ +  ++++wk+++++L++ +Ll+y+  
   mKIAA2016   521    VRKAGWLFFKPlvtlqkerklelvARRKWKQYWVTLKGCTLLFYETY 567  

                   k.......kkpkgsipLsgiqvekvpdn.krkncFeirt.dretlllqae
                   +++++++++ p+  +  +++ v  vp+ +k++++F+++++ ++++l+qa+
   mKIAA2016   568 GknsteqnSAPRCALFAEDSIVQSVPEHpKKEHVFCLSNsCGDVYLFQAT 617  

                   seeerkeWvkaiqsair<-*
                   s+ +++ Wv+ai+sa++   
   mKIAA2016   618 SQTDLENWVTAIHSACA    634  

RBD: domain 1 of 1, from 847 to 918: score 1.4, E = 0.97
                   *->ktirvhLPnnqrsvVevRpGmtvrDaLakalkkRGLnpsacvVrrsg
                          vh  +n  ++V+ +p  +v+D+La a+k+R+L p    + +  
   mKIAA2016   847    VQTYVHFQDNEGVTVTIKPEHRVEDVLALACKMRQLEPTHYGLQLRK 893  

                   dpqeGekkpLdldtdissLpgPeElvvEnl<-*
                        ++k+  +  ++ +    +E v+++    
   mKIAA2016   894 V----VDKSVEWCVPALYEYM-QEQVYDEI    918  

PDZ: domain 1 of 1, from 927 to 1008: score 33.8, E = 4e-06
                   *->evtlekevkrgglGfsikggsdk.....givvsevlpGsgaAeagGr
                      +v+l k      +Gf + ++ d++++ ++i++s+vlp+ + A  gG 
   mKIAA2016   927    DVQLTKTGDMTDFGFAVTVQVDEhqhlnRIFISDVLPD-SLAYGGG- 971  

                   LkeGDqIlsvNGqdvenlsheravlalkgsggsevtLtil<-*
                   L++G  I+s+NG++v++l + ++++al + +  +v Lt+    
   mKIAA2016   972 LRKGNEITSLNGEPVSDL-DIQQMEALFSEK--SVGLTLV    1008 

RhoGEF: domain 1 of 1, from 1140 to 1329: score 149.5, E = 6e-41
                   *->vlkElleTEkkYvrdLeildnvymkpLreaaisskpvltpddietiF
                      v+ El+ TEk Yv+dL  l   y++pL+++      +lt+d++e++F
   mKIAA2016  1140    VIQELVDTEKSYVKDLSCLFELYLEPLQNET-----FLTQDEMESLF 1181 

                   sNiediyefhreFLkssLearisssqfedlDekkie.psaqr.....lGd
                   + +++ +ef++ FL   Le++is+s     D   +e+ps+ r+   +lG 
   mKIAA2016  1182 GSLPEMLEFQKVFLE-TLEDAISAS----SDFSVLEtPSQFRkllfsLGG 1226 

                   lFlklkepflqvYgeYcsnkpyAqelleklrqaasnpqFaefldeveass
                    Fl + ++ +++Y  +c+n+  +q +le+   a++  +F+ fld + +  
   mKIAA2016  1227 SFLYY-ADHFKLYSGFCANHIKVQRVLER---AKTDKAFKAFLDARNPTK 1272 

                   ntgAkddavkltLqsLLlkPvqRilrYpLLLkeLLkhtpegedqpdredL
                   +          tL+s+L+kPvqR+l+YpLLLkeL+++t++  +++++  L
   mKIAA2016  1273 QHS-------STLESYLIKPVQRVLKYPLLLKELVSLTDH--ESEEHYHL 1313 

                   kkaldllqdlaksiNe<-*
                    +al++++ +a++iNe   
   mKIAA2016  1314 TEALKAMEKVASHINE    1329 

PH: domain 2 of 2, from 1357 to 1492: score 2.4, E = 13
                   *->vikeGwLlkkg.............gkkswkkRyfvLfndvLlyykdk
                         +G+Ll+ ++ +  ++  + ++++k  +   fv+++ v+l yk+ 
   mKIAA2016  1357    ELSMGELLMHStvswlnpflslgkARKDIELTVFVFKRAVILVYKEN 1403 

                   k.....................kkpkgsipLsgiqvekvpdn..krkncF
                    + +++ ++++++ +++ + +++k +  ip+s +qv+   + +++++ ++
   mKIAA2016  1404 CklkkklpsnsrpahnsadldpFKFRWLIPISALQVRLGNTAgtENNSTW 1453 

                   eirt.dr.......etlllqaeseeerkeWvkaiqsair<-*
                   e++++  + ++++++ + l+++++e +++ vk i+s++r   
   mKIAA2016  1454 ELIHtKSeiegrpeTIFQLCCSDSENKTSIVKVIRSILR    1492 

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