hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mpm/mpm02193/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA2014  ( 1045 res)   mpm02193

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
FH2      Formin Homology 2 Domain                       496.6   1.9e-145   1
Drf_GBD  Diaphanous GTPase-binding Domain               250.3    2.7e-71   1
Drf_FH3  Diaphanous FH3 Domain                          235.3    8.9e-67   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
Drf_GBD    1/1      43   296 ..     1   322 []   250.3  2.7e-71
Drf_FH3    1/1     298   504 ..     1   234 []   235.3  8.9e-67
FH2        1/1     579   943 ..     1   413 []   496.6 1.9e-145

Alignments of top-scoring domains:
Drf_GBD: domain 1 of 1, from 43 to 296: score 250.3, E = 2.7e-71
                   *->lqmpsdeeLVdelFeellkedriflnLpedKreaLrnlsaekKWeli
                       +mp   eL +e+F+ +l      +nLp dK + Lr++++ekKW li
   mKIAA2014    43    TPMPEPCEL-EERFALVL-SS---MNLPPDKARLLRQYDNEKKWDLI 84   

                   cqylskndkgkkkksskselnekaiaSdileilteesspqeYiekLrsga
                   c++   +    k+                        +p +Yi+kL+s +
   mKIAA2014    85 CDQERFQV---KN------------------------PPHTYIQKLQSFL 107  

                   lsekllscsssskehsaknkslgslSpstkvvddgLkvaelesLrVaLrt
                   +   +          + k+++++++  stkv         l+ L+++Lrt
   mKIAA2014   108 DPNVT----------RKKFRRRVQE--STKV---------LRELEISLRT 136  

                   npvsWVkaFgklgNkGliaLlkiLqtllkkkiyelestds.vesgveksk
                   n++ WV++F++ +NkGl++L+++L++ ++ +   +e  +s+ + +++k +
   mKIAA2014   137 NHIGWVREFLNDENKGLDVLVDYLSFAQCSVMFDFEGLESgDDGAFDKLR 186  

                   kdspssedlskasprpsPqqnssqesksqqtlkllsqlsaqaqqlqkqql
                   ++s+s+edl+ ++  + P  ns  +s +q++l+++++             
   mKIAA2014   187 SWSRSIEDLQPPNALSAPFTNSLARSARQSVLRYSTLPG----------- 225  

                   qqsttliektlpsidkklqfecirClKaLMNnklGlkrvLsheesividt
                      ++++++++   +k++ ++ci Cl+a+MN+++G++ v+sh+++  ++ 
   mKIAA2014   226 ---RRALKNSRLVSQKDDVHVCILCLRAIMNYQYGFNLVMSHPHA--VNE 270  

                   lvlsLdssnlktrklaleLLaalClv<-*
                   ++lsL ++n++t+ l+leLLaa+Clv   
   mKIAA2014   271 IALSLNNKNPRTKALVLELLAAVCLV    296  

Drf_FH3: domain 1 of 1, from 298 to 504: score 235.3, E = 8.9e-67
                   *->gGhelvleaiinfkevcdereRFrtlvsaldsfssgeedasleykva
                      gGhe++l a++nfkevc+e +RF+ l++++++     ed +++++va
   mKIAA2014   298    GGHEIILAAFDNFKEVCKELHRFEKLMEYFRN-----EDSNIDFMVA 339  

                   tmqFINalvvagnspedlqfRlhLRsEftelGLdeyleklkntssesdkL
                   +mqFIN++v   +s+ed++fR+hL++Eft+lGL e l+k+++t  es+kL
   mKIAA2014   340 CMQFINIVV---HSVEDMNFRVHLQYEFTKLGLEEFLQKSRHT--ESEKL 384  

                   ddqIklFeenmidvrellddantktkvledleeleerleelkesfaetsv
                   ++qI+++ +n++dv+ ll+da+tk+ +le++eelee++++l+e++ +   
   mKIAA2014   385 QVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSHLTEKLLD--L 432  

                   eldslssvaellsnllkltgaedlllSilQhllllakdseeskLtsyikl
                   e++++++vael+++ll+  ++++             k+++e+    +  +
   mKIAA2014   433 ENENMMRVAELEKQLLQREKELESI-----------KETYENT-SNQVHT 470  

                   leeivqqIllhrtkpsdpkfeqklqenvdegterlld<-*
                   l++++++  ++ ++++   +e + + ++ +g e  l+   
   mKIAA2014   471 LRRLIKE--KEEAFQRRCHLEPSARGLESMGGEA-LA    504  

FH2: domain 1 of 1, from 579 to 943: score 496.6, E = 1.9e-145
                   *->kkepkpkkkLKpLhWdKlnpsqdrgtsvWdkldeesfekkldldlse
                      kk++k+k++L+ ++W++l+p+q+ gt v+ +ld+e++ +  dldl++
   mKIAA2014   579    KKPIKTKFRLPVFNWTALKPNQINGT-VFSELDDEKILE--DLDLDR 622  

                   lEelFsakakkkkekksseksskskkkkkeisvLDpkrsQNiaIlLrkls
                   +EelF++ka++++ +  ++k++ ++k++ ++++L+++r++N+aI+Lrk  
   mKIAA2014   623 FEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKA- 671  

                   klppeeivqAilemDedvLgvvlflkemldllenLlkmaPtkeElkklqe
                   + ++eei++Ai+ +D  +L+        +d++e+L++++Pt+ E+k+l  
   mKIAA2014   672 GRSAEEICRAIHTFDLQTLP--------VDFVECLMRFLPTEAEVKLL-- 711  

                   keykgdekspskLgraEqqFLlelskliprleeRlrallFkstFeeevee
                   ++y  +++++++L+ ++ +F+l +sk ++rl++R+  ++F  +F+++ ++
   mKIAA2014   712 RQYERERQPLEELAAED-RFMLLFSK-VERLTQRMAGMAFLGNFQDNLQM 759  

                   lkpsletleaAseeLreSrkfkklLeliLalGNyMNsGtrrrGnAkGFkL
                   l+p+l++++aAs ++++S+k+k++Le+iLalGNyMNs +r  G ++GFkL
   mKIAA2014   760 LTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSKR--GAVYGFKL 807  

                   ssLlKLsdvKstidnktTLLHflvkeieesEGkrlEeyrKLklpelldfs
                   +sL+ L+d+Kst d+k+TLLHf++ ++ e            k+pel++f+
   mKIAA2014   808 QSLDLLLDTKST-DRKMTLLHFIALTVKE------------KYPELANFW 844  

                   seLshVekAakvdleeLeadvkeLekglkklekelelseeSkvsdeepsd
                    eL++VekAa+v+le++  dvkeL +g++ +++e++ + +          
   mKIAA2014   845 QELHFVEKAAAVSLENVLLDVKELGRGMELIRRECSIHDN---------- 884  

                   kFvevmkeFleeAeekldkLesllkeakelfkelteYFghggedpkdets
                      +v++ Fl + e kldkL+ + k+a e+++ +++YF   ge+pk +t+
   mKIAA2014   885 ---SVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVRYF---GESPK-TTP 927  

                   peeFFkilrdFlnefk<-*
                   p +FF ++ +F++ +k   
   mKIAA2014   928 PSVFFPVFVRFIRSYK    943  

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