hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/smart.HMMs
Sequence file:            /cdna4/rodent/full/goal/mbg/mbg16805/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA1998  ( 1366 res)   mbg16805

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
RhoGEF   Guanine nucleotide exchange factor for Rho/R   233.4    1.9e-65   1
C1       Protein kinase C conserved region 1 (C1) dom    53.1    3.7e-11   1
PH       Pleckstrin homology domain.                     47.9    1.3e-09   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
C1         1/1     694   740 ..     1    61 []    53.1  3.7e-11
RhoGEF     1/1     892  1082 ..     1   211 []   233.4  1.9e-65
PH         1/1    1126  1229 ..     1    82 []    47.9  1.3e-09

Alignments of top-scoring domains:
C1: domain 1 of 1, from 694 to 740: score 53.1, E = 3.7e-11
                   *->Hkfvfrtf.kptfCdvCrksiwgsfkqaaksqglrCseCkvkcHkkC
                      H+fv +tf++   C+ C+k++ g         +l+C +Ck + Hk C
   mKIAA1998   694    HQFVPGTFsGVLQCSGCDKTLLGKE-------SLQCANCKANTHKGC 733  

                   aekvpaqshksglsC<-*
                   ++ vp        +C   
   mKIAA1998   734 KDAVP--------PC    740  

RhoGEF: domain 1 of 1, from 892 to 1082: score 233.4, E = 1.9e-65
                   *->vlkELlqTErnYVrdLkilvevflkpLkkeakssllpllspdevktl
                      v++EL+qTE +++++L i+ evf+k +k+e++      l+++ v+++
   mKIAA1998   892    VIFELMQTEVHHIQTLLIMSEVFRKGMKEELQ------LDHSTVDKI 932  

                   FgpNieeiyefHrrFLdeLeerveewllskdl.Ksernsviedsgerigd
                   F+ +++e++e Hr+F+ +++er++e+     + +s+rn+vi+++g+ + +
   mKIAA1998   933 FP-CLDELLETHRHFFFSMKERRQES-----CaGSDRNFVINQIGDILVQ 976  

                   vFlklfsaeeffkiYseYcsnhpdalellkkLmkkkknpaFqkflkeies
                   +F+++ +a+++++iY+e+cs+h++a++l+k+L   ++n++Fq f+k + s
   mKIAA1998   977 QFSEE-NASKMKRIYGEFCSHHKEAMSLFKEL---QQNKKFQNFIKIRNS 1022 

                   kpncrsksearltLeslLikPvQRltkYpLLLkellkhtppdhedredLk
                   +   r     r++++++++++ QR+tkYp L++++l++t++  e++ dL+
   mKIAA1998  1023 NLLAR-----RRGIPECILLVTQRITKYPVLVERILQYTKERTEEHRDLC 1067 

                   kAleaikelasqvNe<-*
                   kAl++ik+++++v+    
   mKIAA1998  1068 KALGLIKDMIAAVDL    1082 

PH: domain 1 of 1, from 1126 to 1229: score 47.9, E = 1.3e-09
                   *->vikeGwLlkks.k.swkkryfvLfngvLlyyksk..........kpk
                      +++ G +++k+  +++k+  + L ++vLl+ ++k+++      + + 
   mKIAA1998  1126    LLHDGLVYWKTaTgRFKDILALLLTDVLLFLQEKdqkyifaavdQKP 1172 

                   gsipLsgcsvre.p.....cFeivt.dr...tlllqAeseeereeWveal
                    +i+L++++ re +++++++F i+ ++ +++ ++++++s+eer+ W++ +
   mKIAA1998  1173 SVISLQKLIAREvAneergMFLISAsSAgpeMYEIHTNSKEERNNWMRRI 1222 

                   qsaiaka<-*
                   q+a++++   
   mKIAA1998  1223 QQAVESC    1229 

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